| 1. |
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| 2. |
- Abbas, Abdul-Karim, 1959, et al.
(författare)
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Persistent LTP without triggered protein synthesis.
- 2009
-
Ingår i: Neuroscience research. - : Elsevier BV. - 0168-0102. ; 63:1, s. 59-65
-
Tidskriftsartikel (refereegranskat)abstract
- Protein synthesis is believed to be involved in stabilizing synaptic plasticity. Effects lasting longer than about 2-3h are considered to require synthesis of new proteins, implying a functional separation between early (E) and late (L) components. However, the issue of constitutive vs. new protein synthesis is still unclear, especially in young animals. Here, we examined the effects of two protein synthesis inhibitors, anisomycin and emetine, on long-term-potentiation (LTP) in CA1 area of hippocampal slices from 12- to 20-day-old rats. Either drug was applied from -30 min to +30 min with respect to LTP induction, a time window previously reported to be critical. However, the LTP remained stable under the entire recording period of 4h (anisomycin), or 8h (emetine). Proper preparation of emetine solution was evidenced by the fact that, in separate experiments, prolonged treatment with emetine gradually blocked baseline responses. Although no corresponding effect was observed with anisomycin, the drug was judged to be potent by its ability to inhibit yeast growth. The ability of anisomycin to inhibit protein synthesis was further confirmed by radiolabeling experiments assessing the degree of leucine incorporation. Our data suggest that LTP up to at least 8h is not dependent on triggered protein synthesis but can be attained by utilizing proteins already available at induction time.
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| 3. |
- Akner, Gunnar, 1953-, et al.
(författare)
-
Vi står gärna bakom en utfallsbaserad vård
- 2017
-
Ingår i: Dagens Samhälle. - 1652-6511.
-
Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Jörgen Nordenström försöker få det till att vår kritik av värdebaserad vård egentligen handlar om att vi vill ha mer resurser. Han har helt missuppfattat oss, skriver 26 specialistläkare i en replik.
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| 4. |
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| 5. |
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| 6. |
- Alvesson, Mats, et al.
(författare)
-
Pre-understanding : An interpretation-enhancer and horizon-expander in research
- 2022
-
Ingår i: Organization Studies. - : SAGE Publications. - 0170-8406 .- 1741-3044. ; 43:3, s. 395-412
-
Tidskriftsartikel (refereegranskat)abstract
- Pre-understanding – our presuppositions of reality – underlies all research. Many researchers probably also draw productively on their pre-understanding in their studies. However, very few rationales and methodological resources exist for how researchers can enrich their research by mobilizing their pre-understanding more actively and systematically. We elaborate and propose a framework for how researchers more actively, systematically and visibly can bring forward their pre-understanding and use it as a positive input in research, alongside formal data and theory. In particular, we show how researchers, in dialogue with data and theory, can mobilize their pre-understanding as an interpretation-enhancer and horizon-expander throughout the research process, including stimulating imagination and idea generation, broadening the empirical base, and evaluating what empirical material and theoretical ideas are interesting and relevant to pursue.
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| 7. |
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| 8. |
- Alvesson, Mats, et al.
(författare)
-
Reflexive Design in Qualitative Research
- 2022
-
Ingår i: The SAGE Handbook of Qualitative Research Design Vol. 2. - 1 Oliver's Yard, 55 City Road London EC1Y 1SP : SAGE Publications Ltd. - 9781529770278 - 1529770270 - 1526484323 - 9781526484321 ; , s. 23-40
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Qualitative research design is continually evolving. It is not only more established in disciplines beyond the traditional social sciences in which it is a standard choice, but also just as impacted by the changes in what data, technologies, and approaches researchers are using. This Handbook takes readers through the foundational theories, functions, strategies, and approaches to qualitative research design, before showcasing how it negotiates different data and research environments and produces credible, actionable impact beyond the study. Containing contributions from over 90 top scholars from a range of social science disciplines, this Handbook is not just an anthology of different qualitative research designs and how/when to use them; it is a complete exploration of how and why these designs are shaped and how, why, and into what they are evolving. This is a valuable resource for Master's and PhD level students, faculty members, and researchers across a wide range of disciplines such as health, nursing, psychology, social work, sociology, and education. Volume One: Part I: Concepts of Designing Designs in Qualitative Research; Part 2: Theories and Epistemological Contexts of Designing Qualitative Research; Part 3: Elements of Designing Qualitative Research; Part 4: Basic Designs and Research Strategies in Qualitative Research; and Part 5: Mixing Methods in Designing Qualitative Research. Volume Two: Part 6: Designing Qualitative Research for Specific Kinds of Data; Part 7: Designing Qualitative Online and Multimodal Research; Part 8: Designing Qualitative Research for Specific Groups and Areas; Part 9: Designing Qualitative Research in Disciplinary Fields; and Part 10: Designing Qualitative Research for Impact.
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| 9. |
- Alvesson, Mats, et al.
(författare)
-
The Art of Phenomena Construction : A Framework for Coming Up with Research Phenomena beyond ‘the Usual Suspects’
- 2024
-
Ingår i: Journal of Management Studies. - 0022-2380. ; 61:5, s. 1737-1765
-
Tidskriftsartikel (refereegranskat)abstract
- Despite the centrality of research phenomena, the process of their definition is often neglected and reduced to a simple choosing of pre-established subjects of interest. However, good research not only includes empirical work aimed at more or less ‘given as fact’ phenomena. It also involves phenomena construction: that is, the process of generating and establishing phenomena to investigate and theorize. We contend that phenomena construction is not separate from, but integral to, both the empirical and theorizing phases in research. As few phenomena are truly ‘given’ or straightforward to observe, good research calls for careful and creative construction of the phenomenon under investigation. We propose and elaborate a framework that enables researchers to generate and establish research phenomena beyond those currently available in their specific area of interest and, based on this, to produce more imaginative and impactful research.
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| 10. |
- Alvesson, Mats, et al.
(författare)
-
The Problematizing Review : A Counterpoint to Elsbach and Van Knippenberg’s Argument for Integrative Reviews
- 2020
-
Ingår i: Journal of Management Studies. - : Wiley. - 0022-2380 .- 1467-6486. ; 57:6, s. 1290-1304
-
Tidskriftsartikel (refereegranskat)abstract
- In this paper we provide a counterpoint to conventional views on integrative reviews in knowledge development, as exemplified by Elsbach and Van Knippenberg (2020). First, we critique their proposed integrative review by identifying and problematizing several key assumptions underlying it, particularly their idea that the integrative review can simply build on existing studies and lead the way to knowledge. Second, based on this critique, we propose as an alternative the problematizing review, which is based on the following four core principles: the ideal of reflexivity, reading more broadly but selectively, not accumulating but problematizing, and the concept that ‘less is more’. In contrast to the integrative review, which regards reviews as a ‘building exercise’, the problematizing review regards reviews as an ‘opening up exercise’ that enables researchers to imagine how to rethink existing literature in ways that generate new and ‘better’ ways of thinking about specific phenomena.
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| 11. |
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| 12. |
- Antinyan, Vard, 1984, et al.
(författare)
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A Complexity Measure for Textual Requirements
- 2016
-
Ingår i: Proceedings of 2016 Joint Conference of the International Workshop on Software Measurement and the International Conference on Software Process and Product Measurement (Iwsm-Mensura). - : IEEE. - 9781509041473 - 9781509041480
-
Konferensbidrag (refereegranskat)abstract
- Unequivocally understandable requirements are vital for software design process. However, in practice it is hard to achieve the desired level of understandability, because in large software products a substantial amount of requirements tend to have ambiguous or complex descriptions. Over time such requirements decelerate the development speed and increase the risk of late design modifications, therefore finding and improving them is an urgent task for software designers. Manual reviewing is one way of addressing the problem, but it is effort-intensive and critically slow for large products. Another way is using measurement, in which case one needs to design effective measures. In recent years there have been great endeavors in creating and validating measures for requirements understandability: most of the measures focused on ambiguous patterns. While ambiguity is one property that has major effect on understandability, there is also another important property, complexity, which also has major effect on understandability, but is relatively less investigated. In this paper we define a complexity measure for textual requirements through an action research project in a large software development organization. We also present its evaluation results in three large companies. The evaluation shows that there is a significant correlation between the measurement values and the manual assessment values of practitioners. We recommend this measure to be used with earlier created ambiguity measures as means for automated identification of complex specifications.
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| 13. |
- Antinyan, Vard, 1984, et al.
(författare)
-
Defining technical risks in software development
- 2014
-
Ingår i: Joint Conference of the 24th International Workshop on Software Measurement, IWSM 2014 and the 9th International Conference on Software Process and Product Measurement, Mensura 2014; ss RotterdamRotterdam; Netherlands; 6 October 2014 through 8 October 2014. - : IEEE. - 9781479941742
-
Konferensbidrag (refereegranskat)abstract
- Challenges of technical risk assessment is difficult to address, while its success can benefit software organizations appreciably. Classical definition of risk as a 'combination of probability and impact of adverse event' appears not working with technical risk assessment. The main reason of this is the nature of adverse event's outcome which is rather continuous than discrete. The objective of this study was to scrutinize different aspects of technical risks and provide a definition, which will support effective risk assessment and management in software development organizations. In this study we defined the risk considering the nature of actual risks, emerged in software development. Afterwards, we summarized the software engineers' view on technical risks as results of three workshops with 15 engineers of four software development companies. The results show that technical risks could be viewed as a combination of uncertainty and magnitude of difference between actual and optimal design of product artifacts and processes. The presented definition is congruent with practitioners view on technical risk. It supports risk assessment in a quantitative manner and enables identification of potential product improvement areas.
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| 14. |
- Antinyan, Vard, et al.
(författare)
-
Validating software measures using action research a method and industrial experiences
- 2016
-
Ingår i: EASE '16. - New York, NY, USA : Association for Computing Machinery (ACM). - 9781450336918
-
Konferensbidrag (refereegranskat)abstract
- Validating software measures for using them in practice is a challenging task. Usually more than one complementary validation methods are applied for rigorously validating software measures: Theoretical methods help with defining the measures with expected properties and empirical methods help with evaluating the predictive power of measures. Despite the variety of these methods there still remain cases when the validation of measures is difficult. Particularly when the response variables of interest are not accurately measurable and the practical context cannot be reduced to an experimental setup the abovementioned methods are not effective. In this paper we present a complementary empirical method for validating measures. The method relies on action research principles and is meant to be used in combination with theoretical validation methods. The industrial experiences documented in this paper show that in many practical cases the method is effective. © 2016 ACM.
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| 15. |
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| 16. |
- Bolander, Pernilla, et al.
(författare)
-
How Employee Selection Decisions are Made in Practice
- 2013
-
Ingår i: Organization Studies. - : SAGE Publications (UK and US). - 1741-3044 .- 0170-8406. ; 34:3, s. 285-311
-
Tidskriftsartikel (refereegranskat)abstract
- Existing literature on employee selection contains an abundance of knowledge of how selection should take place but almost nothing about how it occurs in practice. This paper presents an ethnomethodological-discourse analytical real-time study of how selection decisions are made in situ. The main findings suggest that selection decision making is characterized by ongoing practical deliberation involving four interrelated discursive processes: assembling versions of the candidates; establishing the versions of the candidates as factual; reaching selection decisions; and using selection tools as sensemaking devices. In addition, this paper identifies two basic forms of selection decision making: one characterized by initial agreement and one characterized by initial disagreement. In each basic form of decision making, selectors reason through the four discursive processes in a methodical, situated and practical manner in order to construct local versions of the candidates and make 'reasonable' selection decisions.
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| 17. |
- Cederholm, Tommy, et al.
(författare)
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Forskaren, samhället och jäv
- 2008
-
Ingår i: Läkartidningen. - 0023-7205. ; 105:16, s. 7-1206
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 18. |
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| 19. |
- Fång, Johan, et al.
(författare)
-
Utveckling av analysmetoder inklusive detektionsgränser
- 2017
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Läkemedel är viktiga för hälsa och ökat välbefinnande i vårt dagliga liv. Läkemedel ger många fördelar såsom förbättrad livskvalitet, och efterfrågan kommer sannolikt att öka i framtiden på grund av en växande åldrande befolkning, kroniska livsstilssjukdomar, expanderande tillväxtmarknader samt framsteg inom den medicinska forskningen. Tyvärr innebär en ökad användning av läkemedel även en ökad belastning på miljön. Konsumtionen av mediciner bland befolkningen utgör den största spridningen av läkemedelsrester till miljön. Läkemedel som inte bryts ner helt i kroppen utsöndras, antingen som metaboliter eller i oförändrad form, via urin och avföring och hamnar i våra reningsverk. I reningsverken kan läkemedelsresterna antingen brytas ner, fastläggas i slammet eller hamna i sjöar, vattendrag och i kustvatten via det renade utgående avloppsvattnet. Utvärderingen av reningseffektiviteten av olika reningstekniker baseras vanligtvis på analyser av koncentration av läkemedelsrester. Det finns dock svårigheter med analysmetoderna då läkemedel utgör en heterogen grupp av ämnen, med stor variation i fysikaliska och kemiska egenskaper. Variationen kräver användandet av generella metoder för provberedning och analys. Påverkan från komplexa matriser, så som avloppsvatten, riskerar att försämra återvinningen av läkemedel vid provupparbetningen samt påverka signalen vid analys på instrument. Till exempel kan den höga halten av andra föreningar i inkommande avloppsvattnet störa analysen så att vissa läkemedel observeras vid lägre koncentrationer i det orenade vattnet än i det mer rena utgående avloppsvattnet. En annan orsak till att halter av läkemedel uppmäts som lägre i inkommande än utgående avloppsvatten kan vara att vissa läkemedel som metaboliseras i människokroppen återfår sin ursprungliga struktur i reningsverksprocessen och därmed uppmäts i större utsträckning i utgående avloppsvatten. Matriseffekter försämrar även detektionsgränserna av östrogena hormoner så att det med dagens analysmetoder är svårt att bestämma deras förekomst i avloppsvatten. Vissa antibiotika interagerar med fria joner från matrisen och bildar kelatkomplex, vilket ger försämrad återvinning och detektion. Då behovet är stort att kunna bedöma reningseffektivitet i avloppsreningsverk och koncentration av ämnen i avloppsvatten som kan påverka miljön har fokus för studien varit att utveckla och utvärdera förbättrade metoder för kvantitativ bestämning av läkemedelsrester i avloppsvatten. Användandet av en generell metod för provberedning och analys av läkemedel i komplexa matriser, så som avloppsvatten, gör det svårt att skilja läkedelssubstanserna från övrigt organiskt material i matrisen. Generella analysmetoder kan dock användas för att få en översiktlig bild av förekommande ämnen och halter i avloppsvatten samt för jämförelser av reningseffektivitet mellan olika reningstekniker eller olika reningsverk. I arbeten där utvärdering av reningseffektiviteten i ett avloppsreningsverk av enskilda ämnen eller halten av enskilda ämnen i utgående avloppsvatten är avgörande, kan t.ex. märkta internstandarder för respektive ämne eller metoder anpassade till enskilda ämnens kemiska fysikaliska egenskaper användas vid analys för att minimera matriseffekter. Resultaten visade att jon-suppression, dvs. nedtryckning av signalen vid analys på grund av konkurrens med koeluerande organiskt material i matrisen, var den viktigaste orsaken till den observerade ökningen i koncentration av läkemedelsrester från inkommande till utgående avloppsvatten. Resultaten visar en genomsnittlig jon-suppression på 56 % för de studerade läkemedlen i inkommande och 33 % i utgående avloppsvatten. Förluster i återvinning orsakat av konkurrens med annat organiskt material i matrisen vid provberedning alternativt omvandling av metaboliter av läkemedelsrester i avloppsvatten var av underordnad betydelse för flertalet ämnen. Risperidon och Fluoxetine visade stor påverkan av behandling avseende omvandlingsprodukter inklusive metaboliter. Utvecklingen av känsligare metod för kvantifiering av östrogena hormoner i utgående avloppsvatten resulterade i haltbestämningar under ng/L, med en kvantifieringsgräns (LOQ; S/N=10) för17-β-östradiol på 0,6 ng/L, östrone på 0,4 ng/L och 17-α-etinylöstradiol på 0,4 ng/L. Studien visade även att en tillsats av EDTA-Na2 till vattenprov innan upparbetning ökade återvinningen av merparten av de studerade antibiotika, och gav även ökad återvinning för de övriga studerade läkemedlen.
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| 20. |
- Ignatov, Dmitriy, et al.
(författare)
-
An mRNA-mRNA Interaction Couples Expression of a Virulence Factor and Its Chaperone in Listeria monocytogenes
- 2020
-
Ingår i: Cell Reports. - : cell press. - 2211-1247. ; 30:12, s. 4027-
-
Tidskriftsartikel (refereegranskat)abstract
- Bacterial pathogens often employ RNA regulatory elements located in the 5' untranslated regions (UTRs) to control gene expression. Using a comparative structural analysis, we examine the structure of 5' UTRs at a global scale in the pathogenic bacterium Listeria monocytogenes under different conditions. In addition to discovering an RNA thermoswitch and detecting simultaneous interaction of ribosomes and small RNAs with mRNA, we identify structural changes in the 5' UTR of an mRNA encoding the post-translocation chaperone PrsA2 during infection conditions. We demonstrate that the 5' UTR of the prsA2 mRNA base pairs with the 3' UTR of the full-length hly mRNA encoding listeriolysin O, thus preventing RNase J1-mediated degradation of the prsA2 transcript. Mutants lacking the hly-prsA2 interaction exhibit reduced virulence properties. This work highlights an additional level of RNA regulation, where the mRNA encoding a chaperone is stabilized by the mRNA encoding its substrate.
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| 21. |
- Johansson, Anette, 1977, et al.
(författare)
-
Wire-Plane Electrode System for Electrical Tree Initiation Exposed to AC and DC Voltage Stress
- 2011
-
Ingår i: The Proceedings of 17th International Symposium on High Voltage Engineering, s. C-025. - 9783800733644
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Electrical treeing in XLPE exposed to DC (of both polarities) and 50 Hz AC voltages has been analysed in a wire-plane electrode geometry using real-time optical detection and microscopic observations. It has been found that treeing mechanisms differ between AC and DC stresses. For AC voltage, the tree initiation and growth is easily observable in real time during the testing. In the case of DC stress a complete breakdown of the XLPE occurs before electrical trees can be discerned with the use of CCD camera. However, in the microscopic observations of the specimens, very fine tree structures can be distinguished. The effect of voltage ramping rate was also analysed. For AC stress, the faster ramping results in a higher tree inception voltage. The opposite trend is true for DC stress, where the faster ramp results in a lower breakdown voltage level. When comparing the effect on polarity of the DC breakdown voltage, negative polarity results in higher voltage levels than positive polarity.
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| 22. |
- Johansson, Marie, et al.
(författare)
-
Framtidens biobaserade byggande och boende : Slutrapport
- 2019
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The aimof the project "Biobased building and living for the future" was to create conditions for increased use of bio-based products and services in the construction sector in Sweden and Europe and to increase the competitiveness of the Swedish timber manufacturing industry. The project has shown ways to develop E-commerce, parts of the production where increased digitalization leads to increased capacity and quality, as well as solutions for development of floor systems, external walls and tall timber buildings. The project has shown development opportunities to increase the use of bio-based products that implemented will increase competitiveness.The project has been divided into eleven sub-projects to study the various aspects of external factors, market conditions and business models, process development and product development. Within each sub-project, several workshops have been carried out to jointly evaluate results and decide the next step in the sub-project. Through joint workshops, the partners have also been able to meet and share results across the sub-projects and spread knowledge and create networks within the industry. The last part is perceived as very valuable by both the companies and the academy / institute.For the joinery value chain, a current situation analysis has been carried out and shown how the development of E-commerce platforms must be combined with process development in order to have a large effect. The results will be utilized in the companies' strategy work ahead. For the timber building value chain, demonstrators have shown development opportunities for both process and product development. The next step for the companies is to evaluate the various solutions linked to their own production conditions.
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| 23. |
- Khosravani, Nina, et al.
(författare)
-
The otic ganglion in rats and its parotid connection: cholinergic pathways, reflex secretion and a secretory role for the facial nerve.
- 2006
-
Ingår i: Exp Physiol. ; 91:1, s. 239-47
-
Tidskriftsartikel (refereegranskat)abstract
- Otic ganglionectomy in rats was found to have affected the parotid gland more profoundly than section of the auriculotemporal nerve as assessed by reduction in gland weight (by 33 versus 20%) and total acetylcholine synthesizing capacity (by 88 versus 76%) 1 week postoperatively and, when assessed on the day of surgery under adrenoceptor blockade, by reflex secretion (by 99 versus 88%). The facial nerve contributed to the acetylcholine synthesizing capacity of the gland. Section of the nerve only, at the level of the stylomastoid foramen, reduced the acetylcholine synthesis by 15% and, combined with otic ganglionectomy, by 98% or, combined with section of the auriculotemporal nerve, by 82%. The facial nerve was secretory to the gland, and the response was of a cholinergic nature. The nerve conveyed reflex secretion of saliva and caused secretion of saliva upon stimulation. Most of the facial secretory nerve fibres originated from the otic ganglion, since after otic ganglionectomy (and allowing for nerve degeneration) the secretory response to facial nerve stimulation was markedly reduced (from 23 to 4 microl (5 min)(-1)). The persisting secretory response after otic ganglionectomy, exaggerated due to sensitization, and the residual acetylcholine synthesizing capacity (mainly depending on the facial nerve) showed that a minor proportion of pre- and postganglionic nerve fibres relay outside the otic ganglion. The great auricular nerve, which like the facial nerve penetrates the gland, caused no secretion of saliva upon stimulation. Avulsion of the auriculotemporal nerve was more effective than otic ganglionectomy in reducing the acetylcholine synthesizing capacity (by 94 versus 88%) and as effective as otic ganglionectomy in abolishing reflex secretion (by 99%). When aiming at parasympathetic denervation, avulsion may be the preferable choice, since it is technically easier to perform than otic ganglionectomy.
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| 24. |
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| 25. |
- Kragh, Jörgen, et al.
(författare)
-
Optimization of thin asphalt layers : state-of-the-art review
- 2011
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- ERA-NET ROAD initiated a transnational research project titled "Optimization of thin asphalt layers" (OPTHINAL). The DRI-BRRC-VTI Consortium was trusted with carrying out the project and began with a State-of-the-Art report covering, among other things, a literature study and an inventory of experience with using thin asphalt layers (TAL). The results of this phase of the project are given in the present report.This study was limited to thin asphalt mixtures with a maximum thickness of 30 mm, which means that surface dressings or slurry seals were outside the scope of the project. Neither were top layers of double-layer porous pavements considered as TAL, even though such top layers often are 20-30 mm thick. Mix design and optimization was the subject of another study in this project and is therefore not treated here. The main conclusions are that the application of TAL is certainly worthwhile, in particular asa renewable “skin” of a stable road construction having sufficient bearing capacity. The skin serves road users’ need for sufficient skidding resistance and other important functions.
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| 26. |
- Kragh, Jörgen, et al.
(författare)
-
Optimization of thin asphalt layers, OPTHINAL. Final report
- 2011
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- ERA-NET ROAD initiated a transnational research project titled "Optimization of thin asphalt layers". Thin asphalt layers have been used extensively and with promising results for more than 15 years in several countries in Europe and abroad. They seem to be cost effective, fast to build and may have good surface properties. In recent years thin asphalt layers have been shown to imply reduced traffic noise levels, increased traffic safety (skid resistance and forward visibility during wet condition) and to be durable compared with traditional alternatives.The DRI-BRRC-VTI Consortium was trusted with carrying out the ERA-NET ROAD project and began with a State-of-the-Art report covering, among other things, a literature study and an inventory of experience with using thin asphalt layers. The results of this phase of the project were documented in a separate project report.The main conclusions were that the application of thin asphalt layers is certainly worthwhile, in particular as a renewable "skin" of a stable road construction having sufficient bearing capacity. The skin serves road users' need for skid resistance and other important functions. Compared with more conventional and traditional surfacing such as dense asphalt concrete 0/11 or stone mastic asphalt 0/11, thin asphalt layers in general come out somewhat better in most respects; for example concerning cost, use of nature resources, rolling resistance, and traffic noise emission. However, there are also drawbacks or problems under special traffic that need to be handled, for example TAL durability when exposed to wear from studded tyres. The availability of premium quality aggregate is a prerequisite for applying thin asphalt layers, and good quality aggregate may be difficult to procure.The present report looks at possibilities to optimize the application of thin asphalt layers, including an analysis of the cost of applying thin asphalt layers compared with the cost of applying more conventional solutions. The study has been limited to thin asphalt layers with a maximum thickness of 30 mm.Recommendations are given concerning the best practice in applying thin asphalt layers and suggestions are given for future research needed to fill the gaps in available knowledge.
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| 27. |
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| 28. |
- Lindskog, Bengt I., et al.
(författare)
-
Medicinsk terminologi
- 2004
-
Bok (övrigt vetenskapligt/konstnärligt)
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| 29. |
- Lindwall, Greta, 1981-, et al.
(författare)
-
Coarsening investigations of precipitates in PM tool steel grades - an effect of nitrogen
- 2012
-
Ingår i: Berg- und Huttenmännische Monatshefte (BHM). - : Springer Science and Business Media LLC. - 0005-8912 .- 1613-7531. ; 157:11, s. 406-413
-
Tidskriftsartikel (refereegranskat)abstract
- We present experimental and theoretical comparisons of the coarsening rate for the MX(X=C, N or C+N) precipitate in five different tool steel grades produced by PowderMetallurgy (PM). The alloys contain different amounts of nitrogen and carbon; ranging fromhigh carbon/low nitrogen to high nitrogen/low carbon. Common for the grades is a highamount of precipitate forming alloying elements resulting in a high fraction of hard phase.Experimentally we have found out that the nitrogen rich precipitates coarsen slower, both forhigher and lower carbon content, than the carbon rich precipitates. Coarsening simulations areperformed utilizing the DICTRA software and an agreement between calculations andmeasurements can be concluded.
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| 30. |
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| 31. |
- Magnér, Jörgen, et al.
(författare)
-
Utvärdering av Alnarp Cleanwater Technology AB:s avloppsreningsanläggning ACT NaturalTM med avseende på läkemedelsrester
- 2014
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- I Sverige finns cirka 700 000 fastigheter med enskilda avlopp, varav cirka 75 % utgörs av markbaserade anläggningar där det renade avloppsvattnet direkt eller via grundvattnet når ytvattenrecipienter. Spridning av läkemedelsrester och kemikalier via avloppsvatten från reningsverk är ett välkänt problem, som bland annat studerats i ett flertal screening projekt på uppdrag av Naturvårdsverket. I genomförda sammanställningar av reningsverkens effektivitet i tidigare screeningprojekt, har läkemedelsubstanser påvisats även i bakgrundssjöar, där enskilda avlopp konstaterats vara den troliga källan. Flera EU-direktiv, Baltic Sea Action Plan och EU:s strategi för östersjöregionen har bland annat medfört ökat fokus på spridning av läkemedelsrester och andra kemikalier till vatten och havsmiljö genom identifiering av prioriterade ämnen. Alnarp Cleanwater Technology har utvecklat ett biologiskt, kretsloppsbaserat system ACT Natural™ för rening av enskilda avlopp.Hypotesen är att ACT Natural™ kan ge en signifikant reduktion av läkemedel i avloppsvatten jämfört med system som saknar vattenväxter, kontinuerlig syrestillförsel, UV-instrålning och tillräckligt lång uppehållstid. Målet med denna studie är att kvantifiera ACT Natural™ förmåga att reducera läkemedelsrester i avloppsvatten.De dominerande reningsstegen hos ACT NaturalTM uppvisade sammantaget en generell trend av högre avskiljning för flertalet läkemedel jämfört med snittet för fyra svenska reningsverk och markbädd som tidigare studerats (Ejhed et al 2012). Tyvärr kunde inte hela reduceringsförmågan av läkemedel hos ACT NaturalTM studeras då försteget uteslöts ur studien på grund av tekniska svårigheter att tillsätta spikningslösningen redan i inloppet. Därav kan det antas att reduktionsförmågan avseende läkemedelsrester i avloppsvatten hos ACT NaturalTM kan ha underskattats.
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| 32. |
- Magnér, Jörgen, et al.
(författare)
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Utvärdering av Alnarp Cleanwater Technology AB:s avloppsreningsanläggning ACT NaturalTM med avseende på läkemedelsrester
- 2014
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- I Sverige finns cirka 700 000 fastigheter med enskilda avlopp, varav cirka 75 % utgörs av markbaserade anläggningar där det renade avloppsvattnet direkt eller via grundvattnet når ytvattenrecipienter. Spridning av läkemedelsrester och kemikalier via avloppsvatten från reningsverk är ett välkänt problem, som bland annat studerats i ett flertal screening projekt på uppdrag av Naturvårdsverket. I genomförda sammanställningar av reningsverkens effektivitet i tidigare screeningprojekt, har läkemedelsubstanser påvisats även i bakgrundssjöar, där enskilda avlopp konstaterats vara den troliga källan. Flera EU-direktiv, Baltic Sea Action Plan och EU:s strategi för östersjöregionen har bland annat medfört ökat fokus på spridning av läkemedelsrester och andra kemikalier till vatten och havsmiljö genom identifiering av prioriterade ämnen. Alnarp Cleanwater Technology har utvecklat ett biologiskt, kretsloppsbaserat system ACT Natural™ för rening av enskilda avlopp. Hypotesen är att ACT Natural™ kan ge en signifikant reduktion av läkemedel i avloppsvatten jämfört med system som saknar vattenväxter, kontinuerlig syrestillförsel, UV-instrålning och tillräckligt lång uppehållstid. Målet med denna studie är att kvantifiera ACT Natural™ förmåga att reducera läkemedelsrester i avloppsvatten. De dominerande reningsstegen hos ACT NaturalTM uppvisade sammantaget en generell trend av högre avskiljning för flertalet läkemedel jämfört med snittet för fyra svenska reningsverk och markbädd som tidigare studerats (Ejhed et al 2012). Tyvärr kunde inte hela reduceringsförmågan av läkemedel hos ACT NaturalTM studeras då försteget uteslöts ur studien på grund av tekniska svårigheter att tillsätta spikningslösningen redan i inloppet. Därav kan det antas att reduktionsförmågan avseende läkemedelsrester i avloppsvatten hos ACT NaturalTM kan ha underskattats.
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| 33. |
- Oskarsson, Jesper, et al.
(författare)
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Quadriceps- och hamstringsstyrka hos en grupp lagidrottande kvinnor 18-60 månader efter främre korsbandsoperation. En pilotstudie.
- 2005
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Ingår i: Nordisk Fysioterapi. - 1402-3024. ; 9, s. 1-8
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Tidskriftsartikel (refereegranskat)abstract
- The aim of the present pilot study was to investigate if there were any side differences in maximum isokinetic strength of quadriceps or hamstrings in a group of females who had resumed their pre-operative team sport after anterior cruciate ligament reconstruction. Fourteen out of 142 eligible females fulfilled the inclusion criteria. Quadriceps and hamstring isokinetic strength was assessed at 60 º/sec and 120º/sec at two occasions. Three maximum trials were allowed at each speed and occasion and the highest torque obtained at each occasion was used for further calculations. With all females included in the statistical tests there were no significant side differences in muscle strength. However, three females showed a side difference of more than 20 % in two of the four strength tests. As it seems unlikely that this difference was caused by chance it points to the possibility of unsatisfactory strength rehabilitation in these three females having resumed sport activities with high demands on their operated knees. However, the results of the present study can by no means be generalized and have to be confirmed by a larger study.
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| 34. |
- Rosal Sandberg, Jaime Axel, 1983-
(författare)
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New efficient integral algorithms for quantum chemistry
- 2014
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The contents of this thesis are centered in the developement of new efficient algorithms for molecular integral evaluation in quantum chemistry, as well as new design and implementation strategies for such algorithms aimed at maximizing their performance and the utilization of modern hardware.This thesis introduces the K4+MIRROR algorithm for 2-electron repulsion integrals, a new ERI integral scheme effective for both segmented and general contraction, which surpasses the performance of all previous ERI analytic algorithms published in the literature. The performance of the K4 kernel contraction schemeis further boosted by the use of some new recurrence relations, CDR/AERR family of recurrences, and the algorithms is further refined for spherical GTOs with the also new SKS method.New prescreening methods for two-electron integrals are also derived, allowing a more consistent methodology for discarding negligible ERI batches. This thesis introduces new techniques useful to pack integrals efficiently and better exploit the underlying modern SIMD or stream processing hardware. These algorithms and methods are implemented in a new library, the Echidna Fock Solver, a hybrid parallelized module for computing Coulomb and Exchange matrices which has been interfaced to the Dalton suite of quantum chemistry programs. Self-Consistent Field and Response Theory calculations in Dalton using the new EFS library are substantially accelerated, also enabling for the first time the use of general contraction basis sets as default basis for extended calculations.The thesis further describes the derivation and implementation of an integral algorithm for evaluating the matrix elements needed for the recently introduced QM/CMM method, for which many of the techniques previously derived are also used, along with a suitable prescreening method for the matrix elements. The implementation is also interfaced to the Dalton quantum chemistry program, and used in production calculations.The last chapter of the thesis is devoted to the derivation of a general analytic solution for type-II Effective Core Potential integrals, arguably one of the most troublesome molecular integrals in quantum chemistry. A new recurrence is introduced for the integrals, and a screening method is presented. Based on these results, a new efficient algorithm for computing type-II ECPs is also described.
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| 43. |
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| 44. |
- Sandberg, Dan T, et al.
(författare)
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Intra-image referencing for simplified assessment of HER2-expression in breast cancer metastases using the Affibody molecule ABY-025 with PET and SPECT.
- 2017
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Ingår i: European Journal of Nuclear Medicine and Molecular Imaging. - : Springer Science and Business Media LLC. - 1619-7070 .- 1619-7089. ; 44:8, s. 1337-1346
-
Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: In phase I/II-studies radiolabelled ABY-025 Affibody molecules identified human epidermal growth factor receptor 2 (HER2) expression in breast cancer metastases using PET and SPECT imaging. Here, we wanted to investigate the utility of a simple intra-image normalization using tumour-to-reference tissue-ratio (T/R) as a HER2 status discrimination strategy to overcome potential issues related to cross-calibration of scanning devices.METHODS: Twenty-three women with pre-diagnosed HER2-positive/negative metastasized breast cancer were scanned with [(111)In]-ABY-025 SPECT/CT (n = 7) or [(68)Ga]-ABY-025 PET/CT (n = 16). Uptake was measured in all metastases and in normal spleen, lung, liver, muscle, and blood pool. Normal tissue uptake variation and T/R-ratios were established for various time points and for two different doses of injected peptide from a total of 94 whole-body image acquisitions. Immunohistochemistry (IHC) was used to verify HER2 expression in 28 biopsied metastases. T/R-ratios were compared to IHC findings to establish the best reference tissue for each modality and each imaging time-point. The impact of shed HER2 in serum was investigated.RESULTS: Spleen was the best reference tissue across modalities, followed by blood pool and lung. Spleen-T/R was highly correlated to PET SUV in metastases after 2 h (r = 0.96, P < 0.001) and reached an accuracy of 100% for discriminating IHC HER2-positive and negative metastases at 4 h (PET) and 24 h (SPECT) after injection. In a single case, shed HER2 resulted in intense tracer retention in blood. In the remaining patients shed HER2 was elevated, but without significant impact on ABY-025 biodistribution.CONCLUSION: T/R-ratios using spleen as reference tissue accurately quantify HER2 expression with radiolabelled ABY-025 imaging in breast cancer metastases with SPECT and PET. Tracer binding to shed HER2 in serum might affect quantification in the extreme case.
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| 45. |
- Sandberg, Jörgen, et al.
(författare)
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Att leda är att skapa förståelse
- 1999
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Ingår i: Pedagogiska magasinet. ; :4/1999
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 46. |
- Sandberg, Jörgen, et al.
(författare)
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Clarifying and expanding the theory typology : A reply to readers’ comments
- 2021
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Ingår i: Marketing Theory. - : SAGE Publications. - 1470-5931 .- 1741-301X. ; 21:3, s. 433-440
-
Tidskriftsartikel (refereegranskat)abstract
- We all want to develop impactful and valuable theories, but what do we mean by ‘theory’? In this piece, we reply to the four readers’ comments on a recent paper in which we propose a theory typology that, in comparison to existing literature, offers a considerably broader, more pluralistic and, at the same time, more precise definition of the meaning(s) of ‘theory’ within academia. In their comments, the readers raise several insightful points that encourage us to further clarify the theory typology, as well as to expand on how it can be useful for researchers in marketing and social science more broadly.
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| 47. |
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| 48. |
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| 49. |
- Sandberg, Jörgen, et al.
(författare)
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Meanings of Theory : Clarifying Theory through Typification
- 2021
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Ingår i: Journal of Management Studies. - : Wiley. - 0022-2380 .- 1467-6486. ; 58:2, s. 487-516
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Tidskriftsartikel (refereegranskat)abstract
- Developing and evaluating scientific knowledge and its value requires a clear – or at least not too unclear – understanding of what ‘theory’ means. We argue that common definitions of theory are too restrictive, as they do not acknowledge the existence of multiple kinds of scientific knowledge, but largely recognize only one kind as ‘theory’, namely explanatory knowledge. We elaborate a typology that broadens and clarifies the meaning of ‘theory’. Consisting of five basic theory types – explaining, comprehending, ordering, enacting and provoking theories – the typology offers a framework that enables researchers to develop and assess knowledge in more varied ways and for a broader set of purposes than is typically recognized, as well as providing a more level playing field within the academic community.
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| 50. |
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