| 3. |
- Landström, Fredrik, 1966-, et al.
(författare)
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Life-threatening Airway Complication After Radioactive Iodine Treatment : A Case Report and Review of the Literature
- 2023
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Ingår i: Anticancer Research. - : International Institute of Anticancer Research. - 0250-7005 .- 1791-7530. ; 43:4, s. 1853-1855
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Forskningsöversikt (refereegranskat)abstract
- BACKGROUND/AIM: Radioactive iodine (RAI) treatment is a cornerstone of treatment of differentiated thyroid carcinoma. Although serious RAI-related complications are uncommon, there have been reports of airway emergencies. Here, a life-threatening airway complication after RAI treatment is reported and previously reported cases are reviewed.CASE REPORT: A 79-year old man with Hürthle cell carcinoma and a remnant thyroid lobe after surgery developed an edema compromising the airway two days after receiving radioactive iodine treatment. An emergency awake intubation and tracheostomy were performed. He could be successfully de-cannulated 17 days later with no long-term complications.CONCLUSION: Although rare, life-threatening airway complications after radioactive iodine treatment, especially with high dose treatment in patients with remaining thyroid tissue, can occur and these patients should be supervised where these complications can be managed.
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| 4. |
- Russo, Alessio
(författare)
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Efficient Exploration and Robustness in Controlled Dynamical Systems
- 2023
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- In this thesis, we explore two distinct topics. The first part of the thesis delves into efficient exploration in multi-task bandit models and model-free exploration in large Markov decision processes (MDPs). This section is driven by the recent research community's interest in uncovering optimal methods to navigate complex decision-making problems. In the second part, we examine attack vectors against MDPs and dynamical systems, which is motivated by the research community's recent push to enhance the safety of Machine Learning models against malicious attacks. Additionally, we explore how to quantify uncertainty in an off-policy evaluation problem, reflecting our ongoing efforts to deepen understanding in this domain. In the first part of the thesis, we present an investigation into the sample complexity of identifying the optimal arm in multi-task bandit problems. In this setting, an agent can select a task and efficiently learn through cross-task knowledge transfer. We derive instance-specific lower bounds that any probably approximately correct (PAC) algorithm should satisfy, revealing both theoretically and empirically significant improvements in scaling over previous methods. Subsequently, we investigate model-free exploration in Reinforcement Learning (RL) problems. By leveraging an information-theoretical viewpoint, we focus on the instance-specific lower bound for the number of samples needed to identify a nearly-optimal policy. We develop an approximation of this lower bound involving quantities that can be inferred using model-free approaches. This leads to a new model-free exploration strategy applicable to continuous MDPs. In the second part of the thesis, we begin by investigating two types of attacks on MDPs: those that alter the observations and those that manipulate the control signals of the victim. We present strategies for designing optimal attacks to minimize the collected reward of the victim. Our strategies show how uncertainties induced by the attack can be modeled using a partially observable MDP (POMDP) framework. We also illustrate how to devise attacks that achieve lower detectability, approaching the problem from a statistical detection perspective. Next, we explore the problem of an eavesdropper aiming to detect changes in an MDP. Approaching this problem from a statistical detection perspective, we introduce a novel definition of online privacy based on the average amount of information per observation of the underlying stochastic system. We derive privacy upper bounds and calculate policies that attain higher privacy levels, supplementing our analysis with examples and numerical simulations. Finally, we present a new off-policy estimation method based on Conformal Prediction that outputs an interval containing the target policy's true reward, demonstrating how to handle the distribution shift between target and behavior policies, and maintain the certainty level while reducing the interval length.Next, we shift our focus onto linear dynamical systems. We study poisoning attacks on data-driven control methods, focusing on how slight changes in the dataset induced by an adversary can significantly deteriorate control methods and potentially destabilize the system. We propose a novel algorithm for computing effective attacks, providing a theoretical basis for our strategy. We also study the detectability of poisoning attacks, focusing on the impact of data poisoning on least-squares estimates. We establish conditions under which the set of models compatible with the data includes the true model of the system, and we analyze different poisoning strategies for the attacker. On the basis of the arguments presented herein, we propose a stealthy data poisoning attack on the least-squares estimator that can evade classical statistical tests.
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