| 1. |
- Simonson, Oscar E., et al.
(författare)
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In Vivo Effects of Mesenchymal Stromal Cells in Two Patients With Severe Acute Respiratory Distress Syndrome
- 2015
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Ingår i: Stem Cells Translational Medicine. - : Oxford University Press (OUP). - 2157-6564 .- 2157-6580. ; 4:10, s. 1199-1213
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Tidskriftsartikel (refereegranskat)abstract
- Mesenchymal stromal cells (MSCs) have been investigated as a treatment for various inflammatory diseases because of their immunomodulatory and reparative properties. However, many basic questions concerning their mechanisms of action after systemic infusion remain unanswered. We performed a detailed analysis of the immunomodulatory properties and proteomic profile of MSCs systemically administered to two patients with severe refractory acute respiratory distress syndrome (ARDS) on a compassionate use basis and attempted to correlate these with in vivo anti-inflammatory actions. Both patients received 2 x 10(6) cells per kilogram, and each subsequently improved with resolution of respiratory, hemodynamic, and multiorgan failure. In parallel, a decrease was seen in multiple pulmonary and systemic markers of inflammation, including epithelial apoptosis, alveolar-capillary fluid leakage, and proinflammatory cytokines, microRNAs, and chemokines. In vitro studies of the MSCs demonstrated a broad anti-inflammatory capacity, including suppression of T-cell responses and induction of regulatory phenotypes in T cells, monocytes, and neutrophils. Some of these in vitro potency assessments correlated with, and were relevant to, the observed in vivo actions. These experiences highlight both the mechanistic information that can be gained from clinical experience and the value of correlating in vitro potency assessments with clinical effects. The findings also suggest, but do not prove, a beneficial effect of lung protective strategies using adoptively transferred MSCs in ARDS. Appropriate randomized clinical trials are required to further assess any potential clinical efficacy and investigate the effects on in vivo inflammation. STEM CELLS TRANSLATIONAL MEDICINE 2015;4:1199-1213
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| 2. |
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| 3. |
- Goya-Esteban, Rebeca, et al.
(författare)
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Long-term characterization of persistent atrial fibrillation: wave morphology, frequency, and irregularity analysis
- 2014
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Ingår i: Medical & Biological Engineering & Computing. - : Springer Science and Business Media LLC. - 0140-0118 .- 1741-0444. ; 52:12, s. 1053-1060
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Tidskriftsartikel (refereegranskat)abstract
- Short-term properties of atrial fibrillation (AF) frequency, f-wave morphology, and irregularity parameters have been thoroughly studied, but not long-term properties. In the present work, f-wave morphology is characterized by principal component analysis, introducing a novel temporal parameter defined by the cumulative normalized variance of the three largest principal components . Based on 7-day recordings from nine patients with stable chronic heart failure and persistent AF, long-term properties were studied in terms of , AF frequency, and sample entropy . The main result of the present study is that detection of circadian rhythms depends on the parameter considered: rhythms were found in six and five (AF frequency) patients, but not always in the same patient. Another important result is that circadian rhythms detected in 7-day recordings could not always be detected in 24-h periods, thus shedding new light on the results in previous studies which all were based on 24-h recordings. Infradian rhythms were found in four and one (AF frequency) patients.
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| 4. |
- Goya-Esteban, Rebeca, et al.
(författare)
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Seven-day analysis of atrial fibrillation and circadian rhythms
- 2013
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Ingår i: BIOSIGNALS 2013 - Proceedings of the International Conference on Bio-Inspired Systems and Signal Processing. - 9789898565365 ; , s. 20-24
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Konferensbidrag (refereegranskat)abstract
- In the present work, f-wave morphology is characterized by principal component analysis and a novel temporal parameter defined by the cumulative normalized variance of the 3 largest principal components (r3). The 7-day behavior of persistent atrial fibrillation (AF) was studied in 9 patients using r3, AF frequency, and sample entropy (SampEn). Detection of circadian rhythms depended on the parameter considered: rhythms were found in 6 (r3, SampEn) and 5 (AF frequency) patients, but interestingly not always in the same patients. Two patients had significant circadian rhythm in all parameters. When a circadian rhythm was significantly present in 7 days, it was usually only significantly present in some of the 24-h segments. It is concluded that detailed AF characterization can be achieved with complementary parameters.
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| 5. |
- Gustafsson, Torfinn, et al.
(författare)
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Authors' response
- 2023
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Ingår i: Journal of Forensic Sciences. - : John Wiley & Sons. - 0022-1198 .- 1556-4029. ; 68:3, s. 1086-1088
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Tidskriftsartikel (refereegranskat)
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| 6. |
- Gustafsson, Torfinn, et al.
(författare)
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The utility of histology in assessing the cause of death in medico-legal autopsies in selected trauma deaths : suspension-, immersion-, fire-, and traffic-related
- 2023
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Ingår i: Journal of Forensic Sciences. - : John Wiley & Sons. - 0022-1198 .- 1556-4029. ; 68:2, s. 509-517
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Tidskriftsartikel (refereegranskat)abstract
- The goal of a medico-legal autopsy is primarily to determine the cause and manner of death. To this end, the pathologist often uses auxiliary analyses, including histology. However, the utility of routine histology in all medico-legal autopsies is unknown. Earlier studies on the utility of routine histology have shown inconsistent effects, with some studies recommending it and others rejecting it. To study the degree to which histology informs on the underlying cause of death, we sent autopsy reports from suspension-, immersion-, fire-, and traffic-related deaths to senior board-certified forensic pathologists and had them assess the cause of death, first without knowledge of the histological findings and then with knowledge thereof. Fifty cases were identified in each of four subgroups: fire-, immersion-, suspension-, and traffic-related deaths. The autopsy reports were anonymized, and the histological findings and conclusions were removed. Two board-certified forensic pathologists independently reviewed the reports in each subgroup and assessed the manner and underlying cause of death (including their certainty of this assessment on a five-level scale) with and without access to histological findings. The probability of changing the underlying cause of death posthistology was low in all study groups. There was a slight increase in the degree of certainty posthistology in cases where the underlying cause of death was not changed, but only when the antehistology certainty was low. Our results suggest that histology does not meaningfully inform on the underlying cause of death in suspension-, immersion-, fire-, and traffic-related deaths except when antehistology certainty is low.
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| 7. |
- Lundberg, Oscar, et al.
(författare)
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Cycles of innovation and alignment in digital transformation : investigating the dynamics of resource recombination in a construction firm
- 2020
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Ingår i: Proceedings of the 53rd Hawaii International Conference on System Sciences, HICSS 2020. - : IEEE Computer Society. - 9780998133133 ; , s. 4346-4355
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Konferensbidrag (refereegranskat)abstract
- The generative nature of digital technology implies that during digital transformation (DT), organizations traverse multiple cycles of innovation and resource alignment. Still, extant research mainly chronicles DT as linear and contained phenomenon occurring in response to a dramatic environmental change event. How new resources align with previous ones into novel combinations, the work that supports continuous organizational capability building, and the temporal relationships between cycles of change in DT has received scant attention. Drawing on dynamic capability theory, we analyze innovation and resource alignment cycles driving DT at Lundqvist Trävaru AB, a small Swedish construction firm. Our study has at least two contributions. First, the analysis reveals three types of dynamic capabilities that shape resource generation and alignment in DT. Second, we provide a process model outlining the innovation and alignment cycles that fuel DT as they scale in the focal firm.
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| 8. |
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| 9. |
- Lundberg, Oscar, et al.
(författare)
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Unpacking construction site digitalization: the role of incongruence and inconsistency in technological frames
- 2022
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Ingår i: Construction Management and Economics. - : Taylor & Francis Group. - 0144-6193 .- 1466-433X. ; 40:11-12, s. 987-1002
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Tidskriftsartikel (refereegranskat)abstract
- Construction site operations often involve multiple actors with substantial variations in assumptions, expectations, and knowledge about technology. This could impair digitalization, which involves development of socio-cognitive environments that foster use of digital technology in new organizational procedures. Nevertheless, construction industry digitalization research has mainly addressed firm-level transformation of engineering phases and focused on technology, largely ignoring challenges arising from cognitive differences among actors at construction sites. Thus, we report a case study of attempts to spark construction site digitalization through a shared information management system (IMS). Applying technology frame of reference theory, we demonstrate how differences within groups among actors’ frames (inconsistency) shape group-level frame misalignment (incongruence) and thus digitalization outcomes. The IMS was implemented successfully at the focal firm’s headquarter and regional office levels. However, substantial construction site-level frame inconsistency led to misaligned group-level expectations and generated a fragmented socio-cognitive environment that hindered strategic digitalization. In conclusion, socio-cognitive environments at industry, construction site, and group levels recursively shape individual frames, and harmonization of frames is important to realize construction digitalization.
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| 10. |
- Ortigosa, Nuria, et al.
(författare)
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Characterization of Changes in P-Wave VCG Loops Following Pulmonary-Vein Isolation
- 2021
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Ingår i: Sensors. - : MDPI AG. - 1424-8220. ; 21:5
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Tidskriftsartikel (refereegranskat)abstract
- Atrial fibrillation is the most common type of cardiac arrhythmia in clinical practice. Currently, catheter ablation for pulmonary-vein isolation is a well-established treatment for maintaining sinus rhythm when antiarrhythmic drugs do not succeed. Unfortunately, arrhythmia recurrence after catheter ablation remains common, with estimated rates of up to 45%. A better understanding of factors leading to atrial-fibrillation recurrence is needed. Hence, the aim of this study is to characterize changes in the atrial propagation pattern following pulmonary-vein isolation, and investigate the relation between such characteristics and atrial-fibrillation recurrence. Fifty patients with paroxysmal atrial fibrillation who had undergone catheter ablation were included in this study. Time-segment and vectorcardiogram-loop-morphology analyses were applied to characterize P waves extracted from 1 min long 12-lead electrocardiogram segments before and after the procedure, respectively. Results showed that P-wave vectorcardiogram loops were significantly less round and more planar, P waves and PR intervals were significantly shorter, and heart rate was significantly higher after the procedure. Differences were larger for patients who did not have arrhythmia recurrences at 2 years of follow-up; for these patients, the pre- and postprocedure P waves could be identified with 84% accuracy.
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| 11. |
- Ortigosa, Nuria, et al.
(författare)
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Pulmonary Vein Isolation Induces Changes in Vectorcardiogram P-wave Loops
- 2020
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Ingår i: 2020 Computing in Cardiology, CinC 2020. - 2325-887X .- 2325-8861. - 9781728173825 ; 2020-September
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Konferensbidrag (refereegranskat)abstract
- Pulmonary vein isolation (PVI) is considered a standard treatment of paroxysmal atrial fibrillation aiming to restore and maintain sinus rhythm. The purpose of this study is to analyse how the PVI treatment affects the electrical conduction pattern in the atria. We have compared the morphology of P wave loops extracted from the vectorcardiogram (VCG) before and after PVI. Ten patients suffering from paroxysmal atrial fibrillation who underwent PVI were included in the study. All patients were in sinus rhythm before as well as after the procedure. Vectorcardiogram was obtained using the Kors matrix and the resulting P-waves were automatically delineated. Using these marks, P-wave loops were constructed from the three orthogonal leads of the VCG. The first and second eigenvalues of the P-wave loops increased after the PVI procedure was completed, whereas the ratio of the second to the first eigenvalue, quantifying the roundness of the P-wave loop, decreased significantly after PVI. These results show that PVI induces morphological changes of the P-wave loops.
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