| 1. |
- Iderberg, Hanna, et al.
(författare)
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Predicting clinical outcome and length of sick leave after surgery for lumbar spinal stenosis in Sweden : a multi-register evaluation
- 2019
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Ingår i: European spine journal. - : Springer Science and Business Media LLC. - 0940-6719 .- 1432-0932. ; 28:6, s. 1423-1432
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: Lumbar spinal stenosis (LSS) can be surgically treated, with variable outcome. Studies have linked socioeconomic factors to outcome, but no nation-wide studies have been performed. This register-based study, including all patients surgically treated for LSS during 2008-2012 in Sweden, aimed to determine predictive factors for the outcome of surgery.Methods: Clinical and socioeconomic factors with impact on outcome in LSS surgery were identified in several high-coverage registers, e.g., the national quality registry for spine surgery (Swespine, FU-rate 70-90%). Multivariate regression analyses were conducted to assess their effect on outcome. Two patient-reported outcome measures, Global Assessment of leg pain (GA) and the Oswestry Disability Index (ODI), as well as length of sick leave after surgery were analyzed.Results: Clinical and socioeconomic factors significantly affected health outcome (both GA and ODI). Some predictors of a good outcome (ODI) were: being born in the EU, reporting no back pain at baseline, a high disposable income and a high educational level. Some factors predicting a worse outcome were previous surgery, having had back pain more than 2years, having comorbidities, being a smoker, being on social welfare and being unemployed.Conclusions: The study highlights the relevance of adding socioeconomic factors to clinical factors for analysis of patient-reported outcomes, although the causal pathway of most predictors' impact is unknown. These findings should be further investigated in the perspective of treatment selection for individual LSS patients. The study also presents a foundation of case mix algorithms for predicting outcome of surgery for LSS.
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| 2. |
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| 3. |
- Andersson, Johnn, 1983, et al.
(författare)
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Photovoltaics in Sweden – Success or failure?
- 2021
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Ingår i: Renewable and Sustainable Energy Reviews. - : Elsevier BV. - 1879-0690 .- 1364-0321. ; 143
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Tidskriftsartikel (refereegranskat)abstract
- Promoting global energy transitions while stimulating domestic industrialization requires national policymaking that shapes technological innovation towards specific outcomes. Although this is inherently difficult, historical case studies may bring a better understanding of innovation dynamics and thereby guide the design of future policy interventions. The purpose of this paper is to review and analyze the emergence of Swedish photovoltaics technology from a policy perspective. Our main aim is to provide a retrospective account of historical developments, but we also derive more general insights about technological innovation and related policy challenges. The paper departs from an adapted analytical framework based on the technological innovation systems approach. Our review identifies four decades of Swedish research that has largely failed to drive domestic commercialization, the rise and fall of an industry that mainly served international markets, and a rapidly growing domestic market based on imported products. This situation is the result of mismatches and fragmentation among key innovation processes, which have not been addressed by strategic policy interventions. We suggest that policymakers should promote a full range of innovation processes and consider making innovation support subject to a payback mechanism that delivers a return on public investments even if industries and markets emerge abroad. Our study also demonstrates how the technological innovation systems approach can be extended to include the function commercialization and emphasizes the importance of paying attention to the directionality of technological innovation processes.
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| 4. |
- Andersson, Johnn, 1983, et al.
(författare)
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Shaping factors in the emergence of technological innovations: The case of tidal kite technology
- 2018
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Ingår i: Technological Forecasting and Social Change. - : Elsevier BV. - 0040-1625 .- 1873-5509. ; 132, s. 191-298
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Tidskriftsartikel (refereegranskat)abstract
- The technological innovation systems (TIS) literature offers a detailed and dynamic understanding of factors that enable successful innovation. However, few studies analyze what determines where in space value chain elements are developed as a new technology is diffused on a large scale. The purpose of this paper is to show how the TIS approach can be used to identify and analyze factors that shape spatial trajectories of emerging technologies. It proposes an adapted analytical framework that expands the conventional focus on one-dimensional supporting and blocking factors, to shaping factors that incorporate the spatiality of innovation. The approach is illustrated by examining innovation in tidal kite technology. The analysis finds that a supportive local context in western Sweden during the infancy of tidal kite technology, together with the availability of competent engineers and business development professionals, promoted the formation of locally embedded knowledge and competence. This in turn created a spatial path dependency that made developments gravitate towards Sweden, although the lack of domestic markets has also increasingly driven an expansion of activity to other regions, in particular the UK. Moreover, the analysis shows that shaping, and not only stimulating, the growth of emerging TIS is an important challenge for regional policymakers, and highlights the need for international policy coordination. The paper concludes that analyzing shaping factors in the emergence of new TISs can yield important insights, some of which may be overlooked with a narrow analytical focus on supporting and blocking factors.
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| 5. |
- Andersson, Johnn, 1983, et al.
(författare)
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The outcomes of directionality: Towards a morphology of sociotechnical systems
- 2021
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Ingår i: Environmental Innovation and Societal Transitions. - : Elsevier BV. - 2210-4224 .- 2210-4232. ; 40, s. 108-131
-
Tidskriftsartikel (refereegranskat)abstract
- The sustainability transitions literature departs from the idea that grand challenges such as climate change and rising inequality call for far-reaching changes in sociotechnical systems of production and consumption. This implies a dual interest in the directionality of innovation; some directions of change can be perceived as more desirable, while others may be more plausible due to the path dependent nature of sociotechnical change. The specific characteristics of the potential outcomes of directionality have, however, received little attention. Our aim is therefore to unpack and conceptualize the multidimensional space in which sociotechnical systems may adopt different shapes and configurations. We also provide three illustrative empirical examples where directionality has resulted in systems with different technical, social and spatial characteristics. The ideas put forward in this paper can be seen as a contribution to a morphology of sociotechnical systems and thereby support efforts to investigate or promote specific directions of change.
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| 6. |
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| 7. |
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| 8. |
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| 9. |
- Fogelberg, Hans, 1962, et al.
(författare)
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Understanding reflexive systems of innovation: An analysis of Swedish nanotechnology discourse and organisation
- 2007
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Ingår i: Technology Analysis & Strategic Management. - : Informa UK Limited. - 0953-7325 .- 1465-3990. ; 20:1, s. 65-81
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Tidskriftsartikel (refereegranskat)abstract
- We seek to understand how nanotechnology can contribute to the development of a more sustainable society in general, and to investigate Swedish nanotechnology in particular. On the one hand, the research interest is on how nanoscience can be turned into used products, that is, innovation. On the other hand, we acknowledge that innovation itself is the main producer of risk in modern societies. Inspired by sociology and economics of innovation, we try to capture this by introducing the term 'reflexive system of innovation' to denote a system made up of heterogenous elements, such as discursive components (expressions of knowledge and normative and regulative stands) and organizational components (actors and knowledge), evolving in a non-linear way through external influences as well as self re-enforcing and self-regulating processes. We present the evolution of a Swedish nanotechnology system from the 1980s to the present, as it moves through phases characterized by different kinds of discourse and organization. Evaluating the Swedish case against the concept of a reflexive system of innovation, we find advanced academic knowledge production but a lack of interconnectivity between actors, few actors outside the research community entering the system and a weak function of anticipation, guidance and risk handling. Broad national nanotechnology initiatives (NNIs) may be important for the crystallization of the desired processes, but because neither innovation nor risk can be fully contained, an NNI may only be part of the input to a fully fledged reflexive system of innovation in nanotechnology.
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| 10. |
- Gosens, Jorrit, 1980, et al.
(författare)
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The limits of academic entrepreneurship: Conflicting expectations about commercialization and innovation in China's nascent sector for advanced bio-energy technologies
- 2018
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Ingår i: Energy Research and Social Science. - : Elsevier BV. - 2214-6296. ; 37, s. 1-11
-
Tidskriftsartikel (refereegranskat)abstract
- Despite many years of substantial government research funding, advanced bio-energy technologies in China have seen limited commercial application. Chinese policy makers are increasingly critical of academic organizations for neglecting their role in the transfer of scientific results into industrial applications. We interviewed a selection of Chinese research groups working on bio-energy technologies, and asked them to describe their efforts at commercialization. We found that they focus their research on technological pathways with commercial potential, they patent and attempt to license their technologies, they are highly involved in large scale demonstration plants, and have created a number of new firms. Industry and government may have unrealistic expectations on the maturity and scale of technologies that academia can develop, however. These findings contrast with many earlier analyses of early commercialization stages of novel technologies, which have commonly identified lacking academic entrepreneurship as a root cause in stalling development.
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| 11. |
- Harrysson, Lars, et al.
(författare)
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Cancer, a relational disease exploring the needs of relatives to cancer patients
- 2019
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Ingår i: International Journal of Qualitative Studies on Health and Well-being. - : Informa UK Limited. - 1748-2631 .- 1748-2623. ; 14:1
-
Tidskriftsartikel (refereegranskat)abstract
- Syfte: I denna kvalitativa studie studerade vi erfarenheter bland familjemedlemmar till cancerpatienter. Vårt syfte var att undersöka och differentiera deras behov från de behov som cancer patienten uppvisar.Metod: Fem fokusintervjuer och sex individuella narrativa intervjuer med 17 familje medlemmar till cancerpatiener i Sverige genomfördes och jämförda med 19 intervjuer med cancerpatienter. Vår analys var inspirerad av klassisk grundad teori.Resaultat: Familjemedlemmar till cancerpatienter uppvisade egen sjukdom kopplad till höga stressnivåer och svårigheter att erkänna egen stress till följd av pågående jämförelser med cancerpatienten. Familjemedlemmar var fastlåsta i en momentan terrorlik situation där de blev den sjukes skyddsnät. En upplevd oförmåga till att förbättra den sjukes hälsa och välmående bidrog till känslor av skukld. Önskan om att allt skulle vara över var inbäddat i skam då slutet innebar möjlig död.Slutsatser: Genom att erkänna cancer som en sjukdom som påverkar både kropp och relationer kan familjemedlemmar ges kontroll över sina egna kamper skilda från patientens upplevelser. Vi definierar skillnaderi behov mellan cancer patienter och anhöriga. De anhöriga till cancerpatienter kan ges stöd i att utveckla balanserade strategier för mindre stress, ökad trygghet och stunder av förnöjsamhet.
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| 12. |
- Hellsmark, Hans, 1974, et al.
(författare)
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Teknologiska innovationssystem inom energiområdet: En praktisk vägledning till identifiering av systemsvagheter som motiverar särskilda politiska åtaganden
- 2014
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Syftet med denna rapport är att illustrera hur ett praktiskt inriktat ramverk, tekno- logiska innovationssystem (TIS), kan användas av analytiker och beslutsfattare vid departement och myndigheter för att analysera strategiskt viktiga teknikområden ?????????????????????????????????????????????????????????????????????????????I rapporten analyseras fem TIS centrerade kring havsbaserad vindkraft, marin energi, ????????????????????????????????????????????????????????????????????????????????????? systemsvagheter som bromsar områdets vidare utveckling, vilka som kan åtgärdas av systemets aktörer och vilka som motiverar särskilda politiska åtaganden. Rapporten utgör därmed ett underlag för att formulera åtgärder för att åstadkomma ökad innova- tion, teknikspridning och industrialisering inom ovan nämnda teknikområden.Studien har även möjliggjort en jämförande analys av likheter och skillnader ???????????????????????????????????????????????????????????????????????????????? ?????????????????????????????????????????????????????????????????????????????????????? mellan områdena – de är starka respektive svaga av olika orsaker. Detta visar att ???????????????????????????????????????????????????????????????????????Samtidigt har områdena gemensamma drag. Systemets aktörer, där även politiska ???????????????????????????????????????????????????????????????????????????????????? ?????????????????????????????????????????????????????????????????????????????- skapsnätverk. Men de har varit sämre på att skapa tidiga nischmarknader som ger utrymme för fortsatt lärande och kostnadsreduktion. Sådana nischer kan ibland skapas av marknadens aktörer, men ofta krävs politiska styrmedel. De behövs för att investeringar i kunskapsutveckling ska kunna nyttiggöras och för att en bred industriell utveckling inom nya områden skall göras möjlig i Sverige.Vidare presenteras lärdomar kring vad en aktiv teknikpolitik innebär. Två huvud- ??????????????????????????????????????????????????????????????????????????????- hällsbygget och därför bör vara ett politikområde bland många samt att den skarpa ??????????????????????????????????????????????????????????????????????????????- ?????????????????????????????????????????????????????????????????????????????????? ?????????????????????????????????????????????????????????????????????????????????? olika faser av innovationssystemets utveckling.För att lyckas med en aktiv teknikpolitik behövs en hög grad av koordinering ??????????????????????????????????????????????????????????????????????? teknikområden så att ”rätt” typ av åtgärder kan sättas in vid ”rätt” tidpunkt av ”rätt” aktör. TIS-ramverket lyfts här fram som en metod för att skapa ett sådant underlag. Slutligen presenteras en metod för projektbedömningar som syftar till att stötta handläggare i utvärderingar av projekt inom nya teknikområden.Rapporten i sin helhet riktar sig särskilt till beslutsfattare och handläggare vid myndigheter, departement och politiker, men även andra organisationer och indi- vider med intresse av att högt ställda klimatmål ska kunna nås samtidigt som en positiv näringslivsutveckling möjliggörs.
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| 13. |
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| 14. |
- Lamb, David, et al.
(författare)
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RORγt inhibitors block both IL-17 and IL-22 conferring a potential advantage over anti-IL-17 alone to treat severe asthma
- 2021
-
Ingår i: Respiratory Research. - : Springer Science and Business Media LLC. - 1465-9921 .- 1465-993X. ; 22:1
-
Tidskriftsartikel (refereegranskat)abstract
- Background: RORγt is a transcription factor that enables elaboration of Th17-associated cytokines (including IL-17 and IL-22) and is proposed as a pharmacological target for severe asthma. Methods: IL-17 immunohistochemistry was performed in severe asthma bronchial biopsies (specificity confirmed with in situ hybridization). Primary human small airway epithelial cells in air liquid interface and primary bronchial smooth muscle cells were stimulated with recombinant human IL-17 and/or IL-22 and pro-inflammatory cytokines measured. Balb/c mice were challenged intratracheally with IL-17 and/or IL-22 and airway hyperreactivity, pro-inflammatory cytokines and airway neutrophilia measured. Balb/c mice were sensitized intraperitoneally and challenged intratracheally with house dust mite extract and the effect of either a RORγt inhibitor (BIX119) or an anti-IL-11 antibody assessed on airway hyperreactivity, pro-inflammatory cytokines and airway neutrophilia measured. Results: We confirmed in severe asthma bronchial biopsies both the presence of IL-17-positive lymphocytes and that an IL-17 transcriptome profile in a severe asthma patient sub-population. Both IL-17 and IL-22 stimulated the release of pro-inflammatory cytokine and chemokine release from primary human lung cells and in mice. Furthermore, IL-22 in combination with IL-17, but neither alone, elicits airway hyperresponsiveness (AHR) in naïve mice. A RORγt inhibitor specifically blocked both IL-17 and IL-22, AHR and neutrophilia in a mouse house dust mite model unlike other registered or advanced pipeline modes of action. Full efficacy versus these parameters was associated with 90% inhibition of IL-17 and 50% inhibition of IL-22. In contrast, anti-IL-17 also blocked IL-17, but not IL-22, AHR or neutrophilia. Moreover, the deregulated genes in the lungs from these mice correlated well with deregulated genes from severe asthma biopsies suggesting that this model recapitulates significant severe asthma-relevant biology. Furthermore, these genes were reversed upon RORγt inhibition in the HDM model. Cell deconvolution suggested that the responsible cells were corticosteroid insensitive γδ-T-cells. Conclusion: These data strongly suggest that both IL-17 and IL-22 are required for Th2-low endotype associated biology and that a RORγt inhibitor may provide improved clinical benefit in a severe asthma sub-population of patients by blocking both IL-17 and IL-22 biology compared with blocking IL-17 alone.
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| 15. |
- Leizeaga, Ainara, et al.
(författare)
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Using a tropical elevation gradient to evaluate the impact of land‐use intensity and forest restoration on the microbial use of organic matter under climate change
- 2022
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Ingår i: Global Biogeochemical Cycles. - 0886-6236. ; 36:4
-
Tidskriftsartikel (refereegranskat)abstract
- We investigated how legacies of land use and climate affected the microbial use of organic matter (OM) along a tropical climate gradient in Ethiopia. Four levels of land-use intensity ranging from croplands to pristine forests were assessed along a gradient from cool and moist high altitude (MAT = 16°C, MAP = 2,200 mm) to hot and dry lowland sites (MAT = 20°C, MAP = 1,050 mm). We resolved the biomass, structure, and growth rates of microbial decomposer communities together with the rates of carbon (C) and nitrogen (N) transformation. To target the legacies of climate and land use, samples were assessed at optimal moisture and standardized temperature in the laboratory. Microbial biomass and the fungal-to-bacterial ratio increased with both legacies of drier climates and higher land-use intensities. In contrast, fungal growth rates increased in humid climates, but were unaffected by land use. The ratio of C mineralization to gross N mineralization decreased with higher humidity and more intensive land use, suggesting a change in microbial resource use from more nutrient-poor to nutrient-rich OM. Mineralization of nutrient-poor OM implied a lower nutrient availability to microbes in arid climates and low-intensity land uses, while the mineralization of nutrient-rich OM in humid sites and higher intensity land uses implied a higher microbial nutrient availability there. The difference in respiration between land uses increased with ecosystem aridity, suggesting that OM turnover and soil fertility were more impacted by land use in drier climates. Together, our results suggest that drier subtropical climates will exacerbate the negative effects of land-use intensification on OM turnover and nutrient provisioning for plants.
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| 16. |
- Northcott, Paul A, et al.
(författare)
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Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma.
- 2014
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 511:7510, s. 428-428
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Tidskriftsartikel (refereegranskat)abstract
- Medulloblastoma is a highly malignant paediatric brain tumour currently treated with a combination of surgery, radiation and chemotherapy, posing a considerable burden of toxicity to the developing child. Genomics has illuminated the extensive intertumoral heterogeneity of medulloblastoma, identifying four distinct molecular subgroups. Group 3 and group 4 subgroup medulloblastomas account for most paediatric cases; yet, oncogenic drivers for these subtypes remain largely unidentified. Here we describe a series of prevalent, highly disparate genomic structural variants, restricted to groups 3 and 4, resulting in specific and mutually exclusive activation of the growth factor independent 1 family proto-oncogenes, GFI1 and GFI1B. Somatic structural variants juxtapose GFI1 or GFI1B coding sequences proximal to active enhancer elements, including super-enhancers, instigating oncogenic activity. Our results, supported by evidence from mouse models, identify GFI1 and GFI1B as prominent medulloblastoma oncogenes and implicate 'enhancer hijacking' as an efficient mechanism driving oncogene activation in a childhood cancer.
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| 17. |
- Petersson, Erik, 1985-
(författare)
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Vadstena krigsmanshus : En studie av den svenska kronans inrättning för sårade och gamla soldater cirka 1640–1780
- 2017
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Den här avhandlingen handlar det underhåll till sårade och gamla soldater som den svenskastatsmakten organiserade under tidigmodern tid. Undersökningen tar sin utgångspunkt i den tid närstatsmakten började organisera mer omfattande hjälp för soldater, vilket var slutet på Gustav Vasasoch under Erik XIV:s regeringstid i mitten av 1500-talet. Motiven till att statsmakten organiseradehjälp för en del soldater var att dessa skulle ha offrat sin hälsa och arbetsförmåga i kronans tjänst, menså länge statsmakten fortsatte att vara relativt löst organiserad var även hjälpen till soldaterna avganska liten omfattning. Det ändrades under Gustav II Adolfs regering då planerna på att skapa ettkrigsmanshus i Vadstena etablerades, vilka senare genomfördes efter hans död och institutionen kundeta emot de första soldaterna senast 1640. I krigsmanshuset fick ett trettiotal soldater med familjeruppehälle, samtidigt som soldater boende i andra delar av landet fick stöd från krigsmanshuskassansom också administrerades från Vadstena. Mot slutet av 1600-talet blev kassan proportionellt merbetydelsefull än krigsmanshuset och runt år 1700 försörjde kassan flera tusen soldater runtom i riket.1700-talet innebar stora förändringar, bland annat genom att krigen blev färre, att krigaryrket intelängre var lika attraktivt som karriärväg för adelsmän och att statsmakten utvecklade andra mer civiladelar. Behovet av ett krigsmanshus fanns till sist inte längre och institutionen i Vadstena stängde förboende våren 1784, men kassan fanns kvar in på 1970-talet.
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| 18. |
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| 19. |
- Rosinger, Christoph, et al.
(författare)
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Can enzymatic stoichiometry be used to determine growth-limiting nutrients for microorganisms? - A critical assessment in two subtropical soils
- 2019
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Ingår i: Soil Biology and Biochemistry. - : Elsevier BV. - 0038-0717. ; 128, s. 115-126
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Tidskriftsartikel (refereegranskat)abstract
- The measurement of potential enzymatic activities has been proposed as an efficient method to infer nutrient limitations for microorganisms in environmental samples. To validate this use, confirmation with direct methods of microbial growth responses to resource additions are required. We experimentally manipulated nutrient-poor soils from the afromontane subtropics with relatively low (grassland soils, ca. 4% soil carbon (C)) or high organic matter content (forest soils, ca. 13% soil C) with nutrient additions (plant material added at 8 mg C g−1 soil combined with mineral N and/or P to reach C:N:P mass-ratios of 10:1:1) in a multifactorial design for one month in order to shift the microbial community towards C-, N- or P-limitation. We then measured the responses of the most commonly measured indicator enzymes used to infer growth limiting nutrients, using ß-1,4-glucosidase, ß-1,4-N-acetylglucosaminidase and leucine aminopeptidase, and acid phosphatase as indicators for C-, N- and P-acquiring enzymatic activities, respectively. In the same soil samples, we also determined the responses in bacterial (3H-leucine incorporation) and fungal growth rates (14C-acetate incorporation into ergosterol) to nutrient supplements, and also verified these with biomass responses (microbial PLFA and ergosterol concentrations) to the factorial nutrient loading amendments. Ratios of C-, N-, and P-acquiring enzymes indicated that the grassland soils were primarily P-limited, and secondarily co-limited by C and N, while the forest soils were co-limited by C and P. However, short-term responses in growth rates and respiration to nutrient additions, along with long-term growth rate, respiration and biomass responses to nutrient loading treatments all indicated that bacterial growth, fungal growth and respiration were primarily limited by C in both grassland and forest soils. We conclude that enzymatic ratios do not capture the growth-limiting factors for bacterial growth, fungal growth, or respiration in soil. Furthermore, the addition of C-rich plant material could shift the fungal community into N-limitation, while bacteria were shifted into co-limitation by both C and N, revealing that bacteria and fungi can be limited by different nutrients within the same soil environment.
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| 20. |
- Rosinger, Christoph, et al.
(författare)
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Shifts in microbial stoichiometry upon nutrient addition do not capture growth-limiting nutrients for soil microorganisms in two subtropical soils
- 2022
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Ingår i: Biogeochemistry. - : Springer Science and Business Media LLC. - 0168-2563 .- 1573-515X. ; 159:1, s. 33-43
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Tidskriftsartikel (refereegranskat)abstract
- Microbial stoichiometry has become a key aspect in ecological research as shifts in microbial C:N, C:P and N:P ratios upon nutrient addition are presumed to give insight into relative nutrient limitations for soil microorganisms–with far-reaching implications for biogeochemical processes. However, this expectation has never been tested against direct methods of microbial growth responses to nutrient addition. We therefore manipulated a subtropical grassland and forest soil with multifactorial C-, N- and P-additions during 30 days to induce changes in limiting resources and evaluated the resulting soil microbial growth rates, microbial biomass stoichiometry, potential enzyme activities and microbial community composition. Our results show that microbial stoichiometric shifts upon nutrient addition ambiguously predict growth-limiting nutrients for soil microbes. For example, P- and NP-addition to the grassland soil significantly shifted the microbial N:P ratio, which suggests increased N- relative to P-limitation. Microbial growth responses however indicated that soil microbes remained C limited. The same applies for the forest soil, where P-, CN-, NP- and CNP-additions shifted the microbial N:P ratio, yet microbial growth remained C limited. This indicates that microorganisms can immobilize N and P for storage when C is the main limiting nutrient, and that intracellular storage of N and P is responsible for the observed shifts in microbial stoichiometry. Moreover, our data imply that shifts in microbial C:N ratios do not necessarily indicate shifts in microbial community composition and suggest that soil microorganisms–when subject to resource pulses–are stoichiometrically quite plastic.
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| 21. |
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| 22. |
- Sandén, Björn, 1968, et al.
(författare)
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Nanoteknik i våra hem
- 2008
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Ingår i: Miljöforskning. ; 2008:3, s. 24-25
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 23. |
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| 24. |
- Sandén, Inger, et al.
(författare)
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Routinization and sensitivity : Interaction in oncological follow-up consultations
- 2001
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Ingår i: Health. - : SAGE Publications. - 1363-4593 .- 1461-7196. ; 5:2, s. 139-163
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The empirical data of this study were gathered in the form of audio-taped recordings of dialogues between 21 patients, who had had operations for testicular cancer and three physicians during follow-up consultations. The aim is to inquire into how routine practices affect the goals of checking up the medical conditions and providing patients with reassurance, and how practices affect the treatment of sensitive topics and the patients’ possibilities of bringing up their own problems are affected. The results show that the routines built up by the medical care programme are used as recurrent opportunities for the parties to confirm that the situation is under control and as resources when they talk about the sensitive topics of sexuality and fertility. How the routinization affected the patients’ possibilities of bringing up their own problems cannot be fully determined. Of the 50 initiatives by patients to present their problems, only nine did so solely on their own initiative.
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| 25. |
- Sandén, Tor, et al.
(författare)
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Monitoring Kinetics of Highly Environment Sensitive States of Fluorescent Molecules by Modulated Excitation and Time-Averaged Fluorescence Intensity Recording
- 2007
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Ingår i: Analytical Chemistry. - : American Chemical Society (ACS). - 0003-2700 .- 1520-6882. ; 79:9, s. 3330-3341
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Tidskriftsartikel (refereegranskat)abstract
- In this work, a concept is described for how the kinetics of photoinduced, transient, long-lived, nonfluorescent or weakly fluorescent states of fluorophore marker molecules can be extracted from the time-averaged fluorescence by using time-modulated excitation. The concept exploits the characteristic variation of the population of these states with the modulation parameters of the excitation and thereby circumvents the need for time resolution in the fluorescence detection. It combines the single-molecule sensitivity of fluorescence detection with the remarkable environmental responsiveness obtainable from long-lived transient states, yet does not in itself impose any constraints on the concentration or the fluorescence brightness of the sample molecules that can be measured. Modulation of the excitation can be performed by variation of the intensity of a stationary excitation beam in time or by repeated translations of a CW excitation beam with respect to the sample. As a first experimental verification of the approach, we have shown how the triplet-state parameters of the fluorophore rhodamine 6G in different aqueous enviroments can be extracted. We demonstrate that the concept is fully compatible with low time-resolution detection by a CCD camera. The concept opens for automated transient-state monitoring or imaging on a massively parallel scale and for high-throughput biomolecular screening as well as for more fundamental biomolecular studies. The concept should also be applicable to the monitoring of a range of other photoinduced nonfluorescent or weakly fluorescent transient states, from which subtle changes in the immediate microenvironment of the fluorophore marker molecules can be detected
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| 26. |
- Sandén, Ulrika, et al.
(författare)
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A perspective-taking university course for cancer survivors, loved ones and healthcare professionals
- 2024
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Ingår i: Social Sciences & Humanities Open. - : Elsevier. - 2590-2911. ; 2024:9
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Tidskriftsartikel (refereegranskat)abstract
- This study reports the results of a university course aimed at exploring and improving cooperation in healthcare with both cancer survivors, loved ones and healthcare professionals as students.Central to the course was the understanding of and moving between each other's perspectives. Operating within a framework inspired by problem-based learning (PBL), small groups consisting of at least one cancer survivor, one loved one and one healthcare professional, collaboratively created scenarios based on their personal experiences. The students developed, elaborated, and identified problems and potential solutions. The pedagogical framing illustrated an empowering process of defining and elaborating a problem of their combined concerns, using their different knowledge. Although cooperation presented challenges, most students were able to explore and appreciate each other's perspectives when provided with a safe environment. Our experiences highlight the importance of both contextual safety and personal development as key factors in addressing power imbalances in healthcare.
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| 27. |
- Sandén, Ulrika, et al.
(författare)
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Breaking the patientification process - through co-creation of care, using old arctic survival knowledge
- 2021
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Ingår i: International Journal of Qualitative Studies on Health and Well-being. - : Informa UK Limited. - 1748-2631 .- 1748-2623. ; 16:1
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: Cancer research and connected innovation processes often lack a major component; patient participation. We revisit three studies (a-c) in order to explore how Momentary contentment theory may be used to improve patient participation and psychosocial health.Method: We revisited data from the initial (a) classic grounded theory study on Momentary contentment, based on four years of observation and 14 interviews. It explains a way of dealing with life close to death and morbidity. In the imminence of danger the studied culture resembles the context of cancer patients. The two following studies used focus group interviews with (b) 19 cancer patients and (c) 17 relatives of cancer patients in southern Sweden.Results: We suggest a process where cancer patients are taught to be submissive and that the support they receive from health providers may be counterproductive to contentment; a patientification process. We present alternative ways for people to handle issues such as hope, waiting, knowledge gaps and healthcare navigation while living with cancer. We introduce an alternative to patientification and passive patients where active patients create their own safety and truly participates in their care. Conclusions: We propose clinical studies to introduce such a shift from patentification to co-creation of care.
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| 28. |
- Sandén, Ulrika, et al.
(författare)
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Exploring health navigating design : momentary contentment in a cancer context.
- 2017
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Ingår i: International Journal of Qualitative Studies on Health and Well-being. - : Taylor & Francis. - 1748-2623 .- 1748-2631. ; 12:1, s. 1-12
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: The technocratic and medicalized model of healthcare is rarely optimal for patients. By connecting two different studies we explore the possibilities of increasing quality of life in cancer care.METHODS: The first study captures survival strategies in a historically isolated Arctic village in Norway resulting in Momentary contentment theory, which emerged from analysing four years of participant observation and interview data. The second study conceptualizes everyday life of cancer patients based on in-depth interviews with 19 cancer patients; this was conceptualized as Navigating a new life situation. Both studies used classic grounded theory methodology. The connection between the studies is based on a health design approach.RESULTS: We found a fit between cancer patients challenging life conditions and harsh everyday life in an Arctic village. Death, treatments and dependence have become natural parts of life where the importance of creating spaces-of-moments and a Sense of Safety is imminent to well-being. While the cancer patients are in a new life situation, the Arctic people show a natural ability to handle uncertainties.CONCLUSION: By innovation theories connected to design thinking, Momentary contentment theory modified to fit cancer care would eventually be a way to improve cancer patients' quality of life.
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| 29. |
- Sandén, Ulrika, et al.
(författare)
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Momentary Contentment : A Modern Version of an Old Survival Culture
- 2015
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Ingår i: The Grounded Theory Review. - : Sociology Press. - 1556-1542 .- 1556-1550. ; 14:2, s. 74-85
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Tidskriftsartikel (refereegranskat)abstract
- This is a classic grounded theory based in longitudinal data from everyday life in an environment in Northern Norway characterized by long distances, a harsh climate and people living close to nature and each other. The place has a history of poverty and isolation. Yet, old survival strategies prevail despite modernisation. The theory reveals a culture of momentary contentment with three dimensions: Doing safety, destiny readiness and middle consciousness. This momentary contentment culture explains how the participants resolve their main concern of enjoying life. Doing safety means that common and individual acts create stability. Destiny readiness illuminates a discourse of acceptance, a way of thinking that, with the aid of linguistic strategies, prepares for life changing events. Middle consciousness shows a way of handling difficulties by dividing and separating different phenomena.
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| 30. |
- Sandén, Ulrika, et al.
(författare)
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Nuets förnöjsamhet: en grundad teori om livsval och överlevnadsstrategier
- 2015
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Ingår i: Sociologisk Forskning. - Falun : Sveriges sociologförbund. - 2002-066X .- 0038-0342. ; 52:3, s. 235-256
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Tidskriftsartikel (refereegranskat)abstract
- "Contentment in the moment" is a classic grounded theory exploring safety and contentment within a small community in northern Norway. The purpose of the study was to explore the village's everyday life from a participant's perspective and to develop an understanding of their living conditions. We found different survival strategies, which have their roots in the village's history of poverty, isolation and harsh climate. Today these Strategies have changed from a matter of life and death to a modern psychosocial foundation of contentment. The study is based on four and a half years of observations, in-depth interviews and informal but focused conversations with people living in Polarfjorden. The data was analysed using the constant comparative method of classic grounded theory. In this article we further relate our work to more general sociological theory, more specifically to Charles Tilly's work on reason and routines.
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| 31. |
- Scaini, Anna, et al.
(författare)
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Pathways from research to sustainable development: Insights from ten research projects in sustainability and resilience
- 2024
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Ingår i: AMBIO. - : SPRINGER. - 0044-7447 .- 1654-7209.
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Tidskriftsartikel (refereegranskat)abstract
- Drawing on collective experience from ten collaborative research projects focused on the Global South, we identify three major challenges that impede the translation of research on sustainability and resilience into better-informed choices by individuals and policy-makers that in turn can support transformation to a sustainable future. The three challenges comprise: (i) converting knowledge produced during research projects into successful knowledge application; (ii) scaling up knowledge in time when research projects are short-term and potential impacts are long-term; and (iii) scaling up knowledge across space, from local research sites to larger-scale or even global impact. Some potential pathways for funding agencies to overcome these challenges include providing targeted prolonged funding for dissemination and outreach, and facilitating collaboration and coordination across different sites, research teams, and partner organizations. By systematically documenting these challenges, we hope to pave the way for further innovations in the research cycle.
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| 32. |
- Thodelius, Charlotta, et al.
(författare)
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Kriminologiska perspektiv på dödligt skolvåld
- 2021
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Bok (refereegranskat)abstract
- Dödligt skolvåld ingår i serien Kriminologiska perspektiv på ... och belyser svenska händelser av dödligt eller potentiellt dödligt skolvåld. Ger en samlad bild av dödligt skolvåld i Sverige.- Kombinerar rättsligt material och vetenskaplig litteratur.- Kan användas för att belysa likartade händelser, som attacker i köpcentrum eller synagogor. - Visar hur liknande händelser kan förhindras – och hur man kan begränsa följderna när de väl inträffar.Boken är lämplig för utbildning inom exempelvis kriminologi, juridik, psykologi, sociologi och socialt eller polisiärt arbete. Den kan med fördel användas som fortbildning för professionella inom rättsväsende och brottsförebyggande arbete.
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| 33. |
- Thodelius, Charlotta, 1975, et al.
(författare)
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Lethal school violence in Scandinavia: development of an incident typology and suggestions for prevention
- 2019
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Ingår i: Journal of Risk Research. - : Informa UK Limited. - 1466-4461 .- 1366-9877. ; 22:6, s. 692-700
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Tidskriftsartikel (refereegranskat)abstract
- In this paper we address the question of lethal school violence and suggest some preventive strategies. Previous studies in the field has been dominated of cases from the U.S. or Germany, but in this paper we instead focus on lethal violence which has occurred in Scandinavia. Previous research of lethal violence and prevention against it often stresses the complexity and limitations in research. Mainly since the impossibility to profile perpetrators or make lists of warnings signs. In addition, since lethal violence are rare events, there are methodologic challenges related to studies of the phenomena. In the study the included cases are different acts of lethal violence, occurred 1961-2016 (n=12). In the first analysis the aim is to construct a typology, and in the second analysis the typology is used for analysing suitable prevention strategies. The study emphasizing the relation between perpetrator, victim, school and traceable motive in the typology, and the result conclude three different types of lethal violence. The first is based on interpersonal revenge, the second institutional revenge and the third societal revenge. Two prevention strategies seems suitable one aiming at schools organizational structure and the second to architectural decisions in the design process.
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| 34. |
- Thodelius, Charlotta, 1975, et al.
(författare)
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Lethal school violence: linking conflict, relation and intended victims
- 2016
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Ingår i: Oral presentation at the 2ned Nordic Meeting, Society for Risk Analysis Europe, in Gothenburg 14-15 november, 2016.
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Konferensbidrag (refereegranskat)abstract
- The lethal violence in school are mainly associated with the acts of multiple killings in the educational institutions, so called school shootings. These types of attacks are also challenging to prevent, since the perpetrator often are impossible to profile in advance.Instead of focusing on the perpetrator, the aim in this study is to highlight the relation between school, perpetrator and victim. By developing a typology of lethal school violence in a dominating European context, based on key concepts from previous research. The previous studies of the phenomena are challenged by both definition problems and data collection problems, and previous typologies are often weak in explanation if they are applied in another context. The results indicates that there are three types of lethal violence in the school setting, defined as motivated of interpersonal revenge, institutional revenge and societal revenge. By conducting a study exploring the schools role in the events instead of the offender, the aspects and importance of the school setting in the event becomes stronger and can become the ground for further prevention measurements related to school safety and security.
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| 35. |
- Thulesius, Hans, et al.
(författare)
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Pluralistic retasking. Re-thinking cancer diagnostics from a primary care physician perspective. A grounded theory study.
- 2020
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Ingår i: Core values of family medicine: Threats and opportunities. - : WONCA.
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Konferensbidrag (refereegranskat)abstract
- BackgroundCancer diagnostics is heterogeneous depending on disease type, age, gender, socioeconomical and geographical contexts of patients and caregivers.QuestionsHow could cancer be diagnosed in a more timely way from a primary care perspective?MethodsData from 1752 primary care physician (PCP) respondents in 20 countries and 20 Spanish and 7 Swedish PCP interviewees 2013-2019 analysed with classic grounded theory, especially free text responses to “How do you think the speed of diagnosis of cancer in primary care could be improved?”. Secondary analysis of interviews and literature. OutcomesWe call PCP's ideas on improved cancer work-up pluralistic retasking: task shifting among physicians, nurses, assistants and secretaries involving task redistribution, task sharing, task collaboration, changing tasks – cancer fast tracks or cancer screening instead of cancer case finding when appropriate. Cognitive retasking involves both slow rational thinking in algorithms and fast intuitive thinking through gut feelings. Digital retasking bridges time and place by eHealth to reduce “elsewhereism” of experts and power symmetry issues between patient/caregiver. Shrinking gaps between and amongst patients and caregivers requires care restructuring and reallocation of funds. Care refinancing is thus necessary to improve diagnostic timeliness. Good cancer diagnostics needs good time management. Not too early (to avoid overdiagnosis) and never too late.DiscussionPluralistic retasking is a conceptual summary of multiple strategies needed to optimise the timeliness of cancer diagnostics.Take Home Message for PracticeCan I do something differently to diagnose cancer in a more timely way?
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| 36. |
- Thulesius, Hans, et al.
(författare)
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Pluralistic task shifting for a more timely cancer diagnosis. A grounded theory study from a primary care perspective
- 2021
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Ingår i: Scandinavian Journal of Primary Health Care. - : Taylor & Francis Group. - 0281-3432 .- 1502-7724. ; 39:4, s. 486-497
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Tidskriftsartikel (refereegranskat)abstract
- Objective To explore how cancer could be diagnosed in a more timely way. Design Grounded theory analysis of primary care physicians' free text survey responses to: 'How do you think the speed of diagnosis of cancer in primary care could be improved?'. Secondary analysis of primary care physician interviews, survey responses, literature. Setting Primary care in 20 European orenas Research Group countries. Subjects Primary care physicians: 1352 survey respondents (2013-2016), 20 Spanish and 7 Swedish interviewees (2015-2019). Main outcome measures Conceptual explanation of how to improve timeliness of cancer diagnosis. Results Pluralistic task shifting is a grounded theory of a composite strategy. It includes task sharing - among nurses, physicians, nurse assistants, secretaries, and patients - and changing tasks with cancer screening when appropriate or cancer fast-tracks to accelerate cancer case finding. A pluralistic dialogue culture of comprehensive collaboration and task redistribution is required for effective pluralistic task shifting. Pluralistic task shifting relies on cognitive task shifting, which includes learning more about slow analytic reasoning and fast automatic thinking initiated by pattern recognition; and digital task shifting, which by use of eHealth and telemedicine bridges time and place and improves power symmetry between patients, caregivers, and clinicians. Financial task shifting that involves cost tracking followed by reallocation of funds is necessary for the restructuring and retraining required for successful pluralistic task shifting. A timely diagnosis reduces expensive investigations and waiting times. Also, late-stage cancers are costlier to treat than early-stage cancers. Timing is central to cancer diagnosis: not too early to avoid overdiagnosis, and never too late. Conclusions We present pluralistic task shifting as a conceptual summary of strategies needed to optimise the timeliness of cancer diagnosis.
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| 37. |
- Ågerstam, Helena, et al.
(författare)
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IL1RAP antibodies block IL-1-induced expansion of candidate CML stem cells and mediate cell killing in xenograft models.
- 2016
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Ingår i: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 128:23, s. 2683-2693
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Tidskriftsartikel (refereegranskat)abstract
- Chronic myeloid leukemia (CML) is currently treated with tyrosine kinase inhibitors, but these do not effectively eliminate the CML stem cells. As a consequence, CML stem cells persist and cause relapse in most patients upon drug discontinuation. Furthermore, no effective therapy exists for the advanced stages of the disease. Interleukin-1 receptor accessory protein (IL1RAP; IL1R3) is a coreceptor of interleukin-1 receptor type 1 and has been found upregulated on CML stem cells. Here, we show that primitive (CD34(+)CD38(-)) CML cells, in contrast to corresponding normal cells, express a functional interleukin-1 (IL-1) receptor complex and respond with NF-κB activation and marked proliferation in response to IL-1. IL1RAP antibodies that inhibit IL-1 signaling could block these effects. In vivo administration of IL1RAP antibodies in mice transplanted with chronic and blast phase CML cells resulted in therapeutic effects mediated by murine effector cells. These results provide novel insights into the role of IL1RAP in CML and a strong rationale for the development of an IL1RAP antibody therapy to target residual CML stem cells.
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