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- Birgegård, Gunnar, 1944-, et al.
(författare)
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Erythropoetin treatment can increase 2,3-diphosphoglycerate levels in red blood cells
- 2001
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Ingår i: Scandinavian Journal of Clinical and Laboratory Investigation. - 0036-5513 .- 1502-7686. ; 61:5, s. 337-340
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Tidskriftsartikel (refereegranskat)abstract
- Some patients experience an improved well-being during treatment with recombinant human erythropoietin even with an unchanged Hb level. We have hypothesized that this may not be only a placebo effect. 2,3-diphosphoglycerate (2,3-DPG) in red blood cells increases in response to anaemia/hypoxia and causes a shift of the oxygen dissociation curve, allowing a more effective oxygen delivery. We have investigated red cell 2,3-DPG concentrations during erythropoietin treatment in healthy volunteers as a mediator of a possible physiological explanation. Thirteen healthy subjects with no iron deficiency were recruited and randomly assigned to a treatment group comprising five males and three females and a control group including three males and two females. The treatment group was treated with erythropoietin (Recormon), 20 IE/kg subcutaneously three times/week for 4 weeks. Blood samples were collected at each injection day and 10 days after the last injection and at corresponding times in the control group. B-Hb, red cell 2,3-DPG and P50 were measured by standard techniques and oxygen-releasing capacity was calculated. RESULTS: due to the sampling (26 ml each time, three times/week) the mean Hb level was lowered from 140.5 +/- 5.9 to 128.6 +/- 10.4 g/L in the control group whereas the erythropoietin treatment group maintained a mean Hb level of about 142 g/L (p<0.002). The 2,3-DPG mean level curve as well as that for oxygen releasing capacity also differed significantly between the two groups (p < 0.002), the treatment group showing higher levels. CONCLUSION: treatment with erythropoietin causes an increase in red cell 2,3-DPG levels.
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- Brattby, LE, et al.
(författare)
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Validering av ungdomars kostintag
- 1998
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Ingår i: Scandinavian Journal of Nutrition/Næringsforskning. - 1102-6480 .- 1651-2359. ; 42:1, s. 29-30
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Tidskriftsartikel (refereegranskat)
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| 7. |
- Bratteby, L E, et al.
(författare)
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A 7-day activity diary for assessment of daily energy expenditure validated by the doubly labelled water method in adolescents.
- 1997
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Ingår i: European Journal of Clinical Nutrition. - 0954-3007 .- 1476-5640. ; 51:9, s. 585-91
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: To validate the use of an activity diary and predicted BMR for assessment of daily total energy expenditure (TEE) and physical activity level (PAL = TEE/BMR) in adolescents.DESIGN: TEE and PAL estimated from activity diary records kept for seven days and BMR predicted from age, gender and body weight were compared with the results of doubly labelled water (DLW) measurements and indirect calorimetry performed during the same time period.SETTING: The Unit of paediatric Physiology of the Department of Clinical Physiology, University Hospital, Uppsala, Sweden.SUBJECTS: Fifty randomly selected 15 y old adolescents (25 boys and 25 girls).RESULTS: The mean difference between TEE estimated in all adolescents by the activity diary and by DLW methods was 1.2%. The limits of agreement (mean difference 2 s.d.) were -3.47 and 3.77 MD/d, equivalent to a coefficient of variation of 15%. The mean difference between PAL assessed by activity diary records and by DLW measurements was 0.001, and the limits of agreement between the two methods were 0.54.CONCLUSIONS: The results imply that the activity diary method provides a close estimate of TEE and PAL in population groups.
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- Bratteby, L E, et al.
(författare)
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Daily energy expenditure and physical activity assessed by an activity diary in 374 randomly selected 15-year-old adolescents.
- 1997
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Ingår i: European Journal of Clinical Nutrition. - 0954-3007 .- 1476-5640. ; 51:9, s. 592-600
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: To assess the average daily levels of physical activity, energy expenditure and the time and energy spent a different activities in two cohorts of Swedish adolescents.DESIGN: Total energy expenditure (TEE) and physical activity level (PAL = TEE/basal metabolic rate (BMR)) were estimated in 374 randomly selected healthy adolescents living with two different regions of Sweden on the basis of a seven-day activity diary (AD) and predicted BMR. A validation of the estimates from the AD with the doubly labelled water (DLW) method in a randomly selected subsample of 50 of these subjects is presented elsewhere.SETTING: The Unit of Paediatric of the Department of Clinical Physiology, University Hospital, Uppsala and the Department of Paediatrics, Northern Alvsborg Hospital, Trollhättan, Sweden.RESULTS: No significant differences in TEE and PAL were found between the adolescents of the two regions. High levels of TEE (14.2 and 10.9 MJ/d in boys and girls, respectively) and PAL (1.95 and 1.80) were observed. There was a close association between the PAL and the adolescents and their reported time spent sitting. Those with the lowest PAL values spent 3-6 h longer each day sitting compared to those with the highest PAL values. The results also indicate that everyday activities such as walking and bicycling have a crucial impact on the PAL values.CONCLUSIONS: In the 15 y old adolescents of the two studied regions of Sweden, high and concordant levels of energy expenditure and physical activity were found.
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- Bratteby, L-E, et al.
(författare)
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Physical activity, energy expenditure and their correlates in two cohorts of Swedish subjects between adolescence and early adulthood
- 2005
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Ingår i: European Journal of Clinical Nutrition. - : Springer Science and Business Media LLC. - 0954-3007 .- 1476-5640. ; 59, s. 1324-1334
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To assess physical activity and energy expenditure and to identify their correlates during adolescence and early adulthood. DESIGN: In a cohort study, total energy expenditure (TEE) and physical activity level (PAL) were assessed at 15 and 21 y from a 7-day activity diary and predicted BMR. The influences on TEE and PAL of body size, gender, sexual maturity, physical activity habits, sitting time, region, social conditions, employment, food habits, smoking and alcohol intake were examined in multivariate analyses.Subjects:71 male and 89 female subjects, living in two socioeconomically different regions of Sweden, a university region and an industrial region. SETTING: The university city of Uppsala and the industrial town of Trollhättan. RESULTS: At both 15 and 21 y, PAL and TEE were high, with gender, sitting time and physical activity habits as main correlates. At age 21 y, employment and the mother's educational level also appeared as significant correlates. The relations between the main variables and their correlates were more complex than at age 15 y, and the sitting time was reduced and the activity habits were changed. CONCLUSIONS: A reduction of daily sitting appears to be a major reason why high levels of physical activity and energy expenditure were maintained from 15 to 21 y of age in spite of changed and less frequent activity habits during this interval.
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| 12. |
- Bratteby, L E, et al.
(författare)
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Total energy expenditure and physical activity as assessed by the doubly labeled water method in Swedish adolescents in whom energy intake was underestimated by 7-d diet records.
- 1998
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Ingår i: American Journal of Clinical Nutrition. - : Elsevier BV. - 0002-9165 .- 1938-3207. ; 67:5, s. 905-11
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Tidskriftsartikel (refereegranskat)abstract
- Swedish children and adolescents may be adopting a sedentary lifestyle with low energy expenditures and intakes, but no quantitative data are available. The purpose of the present study in 50 adolescents aged 15 y was to investigate whether assessment of total energy expenditure (TEE) and physical activity level (PAL) by the doubly labeled water method and indirect calorimetry and estimation of energy intake by a 7-d diet record would indicate physical inactivity. The boys' (n = 25) mean weight was 112% and the girls' (n = 25) was 109% of Swedish reference values from 1976; the mean height of both boys and girls was 102% of those reference values. Mean TEE in the boys and girls, 13.82 +/- 1.90 and 10.70 +/- 1.59 MJ/d, and mean PAL (TEE/basal metabolic rate), 1.89 +/- 0.16 and 1.79 +/- 0.22, respectively, were nonsignificantly higher than corresponding figures from other published studies. Mean energy intake as a percentage of TEE was 81.9 +/- 17.9% in the boys and 78.3 +/- 16.4% in the girls. Significant negative correlations were found both between energy intake as a percentage of TEE and percentage body fat and between energy intake as a percentage of TEE and body mass index. These results add to the evidence that 7-d diet records underestimate energy intake in adolescents, particularly those with a tendency for overweight and increased body fat. The results support indications of a trend of increasing body weight and height in Swedish adolescents, but conflict with the presumptions of low physical activity, low energy expenditure, and low energy intake. These results support the view that current recommendations for energy intake during adolescence are too low.
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| 13. |
- Bratteby, L E, et al.
(författare)
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Whole-body mineral measurements in Swedish adolescents at 17 years compared to 15 years of age.
- 2002
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Ingår i: Acta Paediatrica. - 0803-5253 .- 1651-2227. ; 91:10, s. 1031-8
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Tidskriftsartikel (refereegranskat)abstract
- AIM: To provide reference data for bone mineral variables in 15- and 17-y-old adolescents and to analyse the relationships between these variables and measures of bone and body size, gender, puberty, growth, various lifestyle and environmental factors and socioeconomic background.METHODS: In the same 321 randomly selected adolescents (147 boys and 174 girls) living in two different regions of Sweden, the total bone mineral content (TBMC), bone area (BA) and total bone mineral density (TBMD) were assessed by dual-energy X-ray absorptiometry at ages 15 and 17 y. The effects of bone and body size, gender, growth, sexual maturity, physical activity, region of domicile, social conditions, food habits, smoking and alcohol intake on TBMC and TBMD were examined in multivariate analyses.RESULTS: In the 15-y-old adolescents, BA, height, gender, physical activity, maturity and weight explained 91% and 48%, of the variance in TBMC and TBMD, respectively. In similar analyses in the 17-y-olds, the corresponding figures were 92% and 62%, respectively, when BA, height, growth, physical activity, gender and region emerged as significant in the model. In all these analyses, BA explained most of the variance in TBMC and TBMD. No significant reduction of variance was found when different measures of social conditions, smoking, food habits, alcohol or dietary intakes of energy, calcium or vitamin D were included in the models. The reason why region of domicile had a significant impact on TBMC in the 17-y-olds is not known. The fact that the normal fluoride concentration in drinking water (1.1 mg/L) is 10 times higher in the region where TBMC was higher than in the other region is an interesting observation.CONCLUSION: Almost 90% of the variance in TBMC and 50% of that in TBMD was explained by measures of bone and body size and only a few percent by gender, physical activity, Tanner stage, growth and region of domicile.
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| 20. |
- Linde, Torbjörn, et al.
(författare)
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Impaired erythrocyte fluidity during treatment of renal anaemia with erythropoietin
- 1992
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Ingår i: Journal of Internal Medicine. - 0954-6820 .- 1365-2796. ; 231:6, s. 601-606
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Tidskriftsartikel (refereegranskat)abstract
- Seventeen haemodialysis patients with renal anaemia were treated with recombinant human erythropoietin (rhEPO) and observed for 30 weeks. The viscosity of whole blood and plasma, the erythrocyte aggregation tendency, and the erythrocyte deformability, measured as fluidity, were analysed every second week. All patients responded with increasing haematocrit and whole-blood viscosity. The plasma viscosity and the erythrocyte aggregation tendency were already increased before the start of treatment, and remained unchanged during treatment. The basal erythrocyte fluidity tended to be impaired, although not significantly so. During treatment, significant impairment of fluidity was observed at the beginning of the treatment period. After 24 weeks the fluidity started to increase, and it later reached values observed before the start of treatment. Hence, the quality of the erythrocytes formed during the corrective phase of rhEPO treatment differs in some respects from that of cells formed at a normal production rate. The impaired fluidity might have important implications for the flow resistance in small vessels, and contribute to the development or aggravation of hypertension that is often seen during rhEPO treatment.
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| 21. |
- Linde, Torbjörn, et al.
(författare)
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Reduced oxygen affinity contributes to improved oxygen releasing capacityduring erythropoietin treatment of renal anaemia
- 1993
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Ingår i: Nephrology, Dialysis and Transplantation. - 0931-0509 .- 1460-2385. ; 8:6, s. 524-529
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Tidskriftsartikel (refereegranskat)abstract
- In addition to haemoglobin concentration, haemoglobin oxygen affinity plays a major role in the oxygen releasing capacity of the blood. In this study we have measured oxygen affinity as P50 and calculated the oxygen releasing capacity of blood from 10 haemodialysis patients treated with erythropoietin (rHuEpo). The patients were examined with different assays before start of treatment, after 11 weeks, and after 27 weeks. During the first phase of treatment the oxygen releasing capacity improved because of an increase in the haemoglobin concentration and P50. During the second phase there was a further significant increase in haemoglobin concentration, but due to a decrease in the P50 value the oxygen releasing capacity remained unchanged. Despite an unchanged oxygen releasing capacity and total blood volume, the antihypertensive treatment had to be increased during that phase of treatment. An increase in whole-blood viscosity may explain the increased need of antihypertensive drugs. The increase in P50 during the first phase of rHuEpo treatment can probably be explained by decreased mean age of the erythrocyte population and implies that the beneficial effect is greater than could be concluded from the increase in haemoglobin concentration.
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| 23. |
- Sandhagen, B
(författare)
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Blodgasbestämning
- 2000
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Ingår i: In: Lungfysiologi och diagnostik vid lungsjukdom. ; , s. 141-145
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 26. |
- Xu, H., et al.
(författare)
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Lipophilic index, kidney function, and kidney function decline
- 2016
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Ingår i: NMCD. Nutrition Metabolism and Cardiovascular Diseases. - : Elsevier BV. - 0939-4753 .- 1590-3729. ; 31, s. 177-177
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Tidskriftsartikel (refereegranskat)abstract
- Background and aims: Unhealthy dietary fats are associated with faster kidney function decline. The cell membrane composition of phospholipid fatty acids (FAs) is a determinant of membrane fluidity and rheological properties. These properties, which have been linked to kidney damage, are thought to be reflected by the lipophilic index (LI). We prospectively investigated the associations of LI with kidney function and its decline. Methods and results: Observational study from the Prospective Investigation of Vasculature in Uppsala Seniors including 975 men and women with plasma phospholipid FAs composition and cystatin-C estimate glomerular filtration rate (eGFR). Of these, 780 attended reexamination after 5 years, and eGFR changes were assessed. Participants with a 5-year eGFR reduction >= 30% were considered chronic kidney disease (CKD) progressors (n = 198). LI was calculated as the sum of the products of the FA proportions with the respective FAs melting points. Blood rheology/viscosity measurements were performed in a random subsample of 559 subjects at baseline. Increased LI showed a statistically significant but overall weak association with blood, plasma viscosity (both Spearman rho = 0.16, p < 0.01), and erythrocyte deformability (rho = -0.09, p < 0.05). In cross-sectional analyses, LI associated with lower eGFR (regression coefficient 3.00 ml/min/1.73 m(2) 1-standard deviation (SD) increment in LI, 95% CI: -4.31, -1.69, p < 0.001). In longitudinal analyses, LI associated with a faster eGFR decline (-2.13 [95% CI -3.58, -0.69] ml/min/1.73 m(2), p < 0.01) and with 32% increased odds of CKD progression (adjusted OR 1.32 [95%, CI 1.05-1.65]). Conclusions: A high LI was associated with lower kidney function, kidney function decline, and CKD progression.
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