| 1. |
- Andersson, B-G, et al.
(författare)
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Grain Alignment in the Circumstellar Shell of IRC+10 degrees 216
- 2022
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 931:2, s. 80-
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Tidskriftsartikel (refereegranskat)abstract
- Dust-induced polarization in the interstellar medium (ISM) is due to asymmetric grains aligned with an external reference direction, usually the magnetic field. For both the leading alignment theories, the alignment of the grain's angular momentum with one of its principal axes and the coupling with the magnetic field requires the grain to be paramagnetic. Of the two main components of interstellar dust, silicates are paramagnetic, while carbon dust is diamagnetic. Hence, carbon grains are not expected to align in the ISM. To probe the physics of carbon grain alignment, we have acquired Stratospheric Observatory for Infrared Astronomy/Higch-resolution Airborne Wideband Camera-plus far-infrared photometry and polarimetry of the carbon-rich circumstellar envelope (CSE) of the asymptotic giant branch star IRC+10 degrees 216. The dust in such CSEs are fully carbonaceous and thus provide unique laboratories for probing carbon grain alignment. We find a centrosymmetric, radial, polarization pattern, where the polarization fraction is well correlated with the dust temperature. Together with estimates of a low fractional polarization from optical polarization of background stars, we interpret these results to be due to a second-order, direct radiative external alignment of grains without internal alignment. Our results indicate that (pure) carbon dust does not contribute significantly to the observed ISM polarization, consistent with the nondetection of polarization in the 3.4 mu m feature due to aliphatic CH bonds on the grain surface.
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| 2. |
- De Bruijn, Paulien, et al.
(författare)
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Mechanical properties of lime-hemp concrete containing shives and fibres
- 2009
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Ingår i: Biosystems Engineering. - : Elsevier BV. - 1537-5110 .- 1537-5129. ; 103:4, s. 474-479
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Tidskriftsartikel (refereegranskat)abstract
- The effect of using different binding agents in combination with hemp shives and fibres in Lime-Hemp Concrete (LHC) building material was examined. LHC is a light composite building material with building lime as binding agents and hemp (Cannabis sativa) as a renewable raw material from agriculture. Contemporary LHC only uses the woody core part of the hemp, the shive. However, using both hemp shives and fibres may improve the mechanical strength, eliminating the need for a fibre separation process. The aim was to elucidate the feasibility of using the entire fragmented hemp stalk in an LHC, and to determine some important material properties such as compressive strength, splitting tensile strength, water sorption and frost resistance. LHC with varying inclusions of the lime-based binders were tested, as were five mixes using the binding agents hydrated lime, hydraulic lime, and cement. Specimens were cured for 12 weeks at room temperature and 40 days in a carbonation room (4.5 vol% CO2), and tested for mechanical properties, water sorption and frost resistance. Using both shives and fibres in LHC may be advantageous for countries such as Sweden where facilities for separating hemp from shives are not commercially available.
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| 3. |
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| 4. |
- Glimelius, Bengt, et al.
(författare)
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U-CAN : a prospective longitudinal collection of biomaterials and clinical information from adult cancer patients in Sweden.
- 2018
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Ingår i: Acta Oncologica. - : Taylor & Francis. - 0284-186X .- 1651-226X. ; 57:2, s. 187-194
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Tidskriftsartikel (refereegranskat)abstract
- Background: Progress in cancer biomarker discovery is dependent on access to high-quality biological materials and high-resolution clinical data from the same cases. To overcome current limitations, a systematic prospective longitudinal sampling of multidisciplinary clinical data, blood and tissue from cancer patients was therefore initiated in 2010 by Uppsala and Umeå Universities and involving their corresponding University Hospitals, which are referral centers for one third of the Swedish population.Material and Methods: Patients with cancer of selected types who are treated at one of the participating hospitals are eligible for inclusion. The healthcare-integrated sampling scheme encompasses clinical data, questionnaires, blood, fresh frozen and formalin-fixed paraffin-embedded tissue specimens, diagnostic slides and radiology bioimaging data.Results: In this ongoing effort, 12,265 patients with brain tumors, breast cancers, colorectal cancers, gynecological cancers, hematological malignancies, lung cancers, neuroendocrine tumors or prostate cancers have been included until the end of 2016. From the 6914 patients included during the first five years, 98% were sampled for blood at diagnosis, 83% had paraffin-embedded and 58% had fresh frozen tissues collected. For Uppsala County, 55% of all cancer patients were included in the cohort.Conclusions: Close collaboration between participating hospitals and universities enabled prospective, longitudinal biobanking of blood and tissues and collection of multidisciplinary clinical data from cancer patients in the U-CAN cohort. Here, we summarize the first five years of operations, present U-CAN as a highly valuable cohort that will contribute to enhanced cancer research and describe the procedures to access samples and data.
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| 5. |
- Hansen, S., et al.
(författare)
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Prevalence and management of severe asthma in the Nordic countries: findings from the NORDSTAR cohort
- 2023
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Ingår i: ERJ Open Research. - : European Respiratory Society (ERS). - 2312-0541. ; 9:2
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Tidskriftsartikel (refereegranskat)abstract
- Background Real-life evidence on prevalence and management of severe asthma is limited. Nationwide population registries across the Nordic countries provide unique opportunities to describe prevalence and management patterns of severe asthma at population level. In nationwide register data from Sweden, Norway and Finland, we examined the prevalence of severe asthma and the proportion of severe asthma patients being managed in specialist care. Methods This is a cross-sectional study based on the Nordic Dataset for Asthma Research (NORDSTAR) research collaboration platform. We identified patients with severe asthma in adults (aged >= 18 years) and in children (aged 6-17 years) in 2018 according to the European Respiratory Society/American Thoracic Society definition. Patients managed in specialist care were those with an asthma-related specialist outpatient contact (only available in Sweden and Finland). Results Overall, we identified 598 242 patients with current asthma in Sweden, Norway and Finland in 2018. Among those, the prevalence of severe asthma was 3.5%, 5.4% and 5.2% in adults and 0.4%, 1.0%, and 0.3% in children in Sweden, Norway and Finland, respectively. In Sweden and Finland, 37% and 40% of adult patients with severe asthma and two or more exacerbations, respectively, were managed in specialist care; in children the numbers were 56% and 41%, respectively. Conclusion In three Nordic countries, population-based nationwide data demonstrated similar prevalence of severe asthma. In children, severe asthma was a rare condition. Notably, a large proportion of patients with severe asthma were not managed by a respiratory specialist, suggesting the need for increased recognition of severe asthma in primary care.
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| 6. |
- Haugen, Nils E.L., et al.
(författare)
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Spectral characterisation of inertial particle clustering in turbulence
- 2022
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Ingår i: Journal of Fluid Mechanics. - : Cambridge University Press. - 0022-1120 .- 1469-7645. ; 934
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Tidskriftsartikel (refereegranskat)abstract
- Clustering of inertial particles is important for many types of astrophysical and geophysical turbulence, but it has been studied predominately for incompressible flows. Here, we study compressible flows and compare clustering in both compressively (irrotationally) and vortically (solenoidally) forced turbulence. Vortically and compressively forced flows are driven stochastically either by solenoidal waves or by circular expansion waves, respectively. For compressively forced flows, the power spectrum of the density of inertial particles is a useful tool for displaying particle clustering relative to the fluid density enhancement. Power spectra are shown to be particularly sensitive for studying large-scale particle clustering, while conventional tools such as radial distribution functions are more suitable for studying small-scale clustering. Our primary finding is that particle clustering through shock interaction is particularly prominent in turbulence driven by spherical expansion waves. It manifests itself through a double-peaked distribution of spectral power as a function of Stokes number. The two peaks are associated with two distinct clustering mechanisms; shock interaction for smaller Stokes numbers and the centrifugal sling effect for larger values. The clustering of inertial particles is associated with the formation of caustics. Such caustics can only be captured in the Lagrangian description, which allows us to assess the relative importance of caustics in vortically and compressively forced turbulence. We show that the statistical noise resulting from the limited number of particles in the Lagrangian description can be removed from the particle power spectra, allowing us a more detailed comparison of the residual spectra. We focus on the Epstein drag law relevant for rarefied gases, but show that our findings apply also to the usual Stokes drag.
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| 7. |
- Idowu, Samuel O., 1985-
(författare)
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Applied Machine Learning in District Heating System
- 2018
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- In an increasingly applied domain of pervasive computing, sensing devices are being deployed progressively for data acquisition from various systems through the use of technologies such as wireless sensor networks. Data obtained from such systems are used analytically to advance or improve system performance or efficiency. The possibility to acquire an enormous amount of data from any target system has made machine learning a useful approach for several large-scale analytical solutions. Machine learning has proved viable in the area of the energy sector, where the global demand for energy and the increasingly accepted need for green energy is gradually challenging energy supplies and the efficiency in its consumption.This research, carried out within the area of pervasive computing, aims to explore the application of machine learning and its effectiveness in the energy sector with dependency on sensing devices. The target application area readily falls under a multi-domain energy grid which provides a system across two energy utility grids as a combined heat and power system. The multi-domain aspect of the target system links to a district heating system network and electrical power from a combined heat and power plant. This thesis, however, focuses on the district heating system as the application area of interest while contributing towards a future goal of a multi-domain energy grid, where improved efficiency level, reduction of overall carbon dioxide footprint and enhanced interaction and synergy between the electricity and thermal grid are vital goals. This thesis explores research issues relating to the effectiveness of machine learning in forecasting heat demands at district heating substations, and the key factors affecting domestic heat load patterns in buildings.The key contribution of this thesis is the application of machine learning techniques in forecasting heat energy consumption in buildings, and our research outcome shows that supervised machine learning methods are suitable for domestic thermal load forecast. Among the examined machine learning methods which include multiple linear regression, support vector machine, feed forward neural network, and regression tree, the support vector machine performed best with a normalized root mean square error of 0.07 for a 24-hour forecast horizon. In addition, weather and time information are observed to be the most influencing factors when forecasting heat load at heating network substations. Investigation on the effect of using substation's operational attributes, such as the supply and return temperatures, as additional input parameters when forecasting heat load shows that the use of substation's internal operational attributes has less impact.
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| 8. |
- Mattsson, Lars, et al.
(författare)
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AGB Winds with Gas-Dust Drift in Stellar Evolution Codes
- 2021
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Ingår i: Universe. - : MDPI AG. - 2218-1997. ; 7:5
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Tidskriftsartikel (refereegranskat)abstract
- A significant fraction of new metals produced in stars enter the interstellar medium in the form of dust grains. Including dust and wind formation in stellar evolution models of late-stage low- and intermediate-mass stars provides a way to quantify their contribution to the cosmic dust component. In doing so, a correct physical description of dust formation is of course required, but also a reliable prescription for the mass-loss rate. Here, we present an improved model of dust-driven winds to be used in stellar evolution codes and insights from recent detailed numerical simulations of carbon-star winds including drift (decoupling of dust and gas). We also discuss future directions for further improvement.
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| 9. |
- Sandin, Bengt, 1949-, et al.
(författare)
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Inledning
- 2006
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Ingår i: Normalitetens förhandling och förvandling.. - Stockholm : Brutus Östlings Bokförlag Symposion. - 9171397736 - 9789171397737 ; , s. -279
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Vad innebär det egentligen att vara ett alldeles vanligt barn? Är det detsamma som att vara normal eller att ha önskvärda egenskaper? Vilka är i så fall önskvärda egenskaper och vem definierar dem?Detta är några av frågorna som angrips i antologin Normalitetens förhandling och förvandling där bidragen utgår från såväl vetenskapliga diskussioner som vardagliga sammanhang. Det handlar om allt från den dagliga verksamheten i en högstadieklass, barn med läs- och skrivsvårigheter, specialklasser för begåvade barn till gymnasieklasser för ungdomar med diagnosen Aspergers syndrom. Författarna spårar på olika sätt de processer som bidrar till att skapa och upprätthålla, men även ifrågasätta, förhandla och förändra normalitet.
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| 10. |
- Sandin, Christer
(författare)
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A Study of Grain Drift in C Stars : Theoretical Modeling of Dust-Driven Winds in Carbon-Rich Pulsating Giant Stars
- 2003
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- A major fraction of stars will pass through a short period of dramatic events in their final evolutionary stage. Low- to intermediate-mass stars, studied here, are stripped of their outer parts in a slow massive wind. This mass loss reshapes both the star and the surrounding medium. The formation of the wind is a consequence of the non-linear interaction of a number of physical processes. Stellar pulsations and efficient dust formation are examples of such key processes. Time-dependent theoretical models, in combination with observations, are useful tools for understanding these winds.The main object of this thesis has been the physical improvement of a theoretical wind model. Here the coupling between the dust and gas in the wind is studied in further detail, allowing drift. The methods that have been developed earlier to describe the micro-physical interaction are overviewed and summarized. Previously dust has often been assumed to move at the same velocity as gas. New time-dependent wind models are presented where grain drift has been treated self-consistently. Specifically, the coupling between dust and gas in the wind has been modeled more realistically, with descriptions of both the modified momentum and energy balances, and drift dependent dust formation. The results of these new ``drift models'' have been compared with the results of non-drift models. A general result of the study is that the effects of drift are significant and difficult to predict if a simple analytical theory is used. It has been found that dust in drift models tends to accumulate in certain dense regions, an accumulation that was not possible without drift. Moreover the new models show an increased variability in the wind structure. The use of drift in dust formation tends to markedly increase the produced dust. Some sets of model parameters lead to a wind without including drift, but a corresponding wind does not form when drift is included -- and vice versa. The effects of drift are important and can probably not be ignored in realistic models.
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| 11. |
- Sandin, Christer, et al.
(författare)
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Properties of the three-dimensional structure in the central region of the supernova remnant SNR 0540−69.3
- 2013
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 432:4, s. 2854-2868
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Tidskriftsartikel (refereegranskat)abstract
- We present and discuss new visual wavelength-range observations of the inner regions of the supernova remnant SNR 0540−69.3 that is located in the Large Magellanic Cloud (LMC). These observations provide us with more spatial and spectral information than were previously available for this object. We use these data to create a detailed three-dimensional model of the remnant, assuming linear expansion of the ejecta. With the observations and the model, we study the general three-dimensional structure of the remnant, and the influence of an active region in the remnant – a ‘blob’ – that we address in previous papers. We used the fibre-fed integral-field Visual Multi-Object Spectrograph at the Very Large Telescope of the European Southern Observatory. The observations provide us with three-dimensional data in [O iii] λ5007 and [S ii] λλ6717, 6731 at a 0.33 arcsec × 0.33 arcsec spatial sampling and a velocity resolution of about 35 km s− 1. We decomposed the two, partially overlapping, sulphur lines and used them to calculate electron densities across the remnant at a high signal-to-noise ratio. In our study, we recover results of previous studies, but we are more importantly able to obtain more detailed information than before. Our analysis reveals a structure that stretches from the position of the ‘blob’, and into the plane of the sky at a position angle of PA ≃ 60°. Assuming a remnant age of 1000 yr and the usual LMC distance, the structure has an inclination angle of about 65° to the line of sight. The position angle is close to the symmetry axis with present and past activity in the visual and the X-ray wavelength ranges. We speculate that the pulsar is positioned along this activity axis, where it has a velocity along the line of sight of a few hundred km s− 1. The ‘blob’ is most likely a region of shock activity, as it is mainly bright in [S ii]; future observations of [O ii] λλ3726, 3729 would be useful to test whether the S/O abundance ratio is higher than average for that location in the remnant. The striking resemblance in X-rays between the pulsar wind nebula (PWN) of SNR 0540−69.3 and the Crab, in combination with our findings in this paper, suggests that the symmetry axis is part of a torus in the PWN. This is in agreement with the original suggestion by Gotthelf & Wang.
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| 12. |
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| 13. |
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| 14. |
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| 15. |
- Sandin, Christer, et al.
(författare)
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Three-component modeling of C-rich AGB star winds : II. The effects of drift in long-period variables
- 2003
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Ingår i: Astronomy & Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 404, s. 789-807
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Tidskriftsartikel (refereegranskat)abstract
- We present three-component wind models for carbon-rich pulsating AGB stars. In particular we study the effects of drift in models of long-period variables, meaning that the dust is allowed to move relative to the gas (drift models). In addition we investigate the importance of the degree of variability of the wind structures. The wind model contains separate conservation laws for each of the three components of gas, dust and the radiation field. We use two different representations for the gas opacity, resulting in models with different gas densities in the wind. The effects which we investigate here are important for the understanding of the wind mechanism and mass loss of AGB stars. This study is hereby a necessary step towards more reliable interpretations of observations. We find that the effects of drift generally are significant. They cannot be predicted from models calculated without drift. Moreover, the non-drift models showing the lowest mass loss rates, outflow velocities, and the smallest variability in the degree of condensation do not form drift model winds. The wind formation in drift models is, except for a few cases, generally less efficient and the mass loss consequently lower than in the corresponding non-drift models. The effects of drift are generally larger in the more realistic models using that representation of the gas opacity which results in lower densities. The outflow properties of these models are also - for all cases we have studied - sensitive to the period of the stellar pulsations. A check of the mass loss rates against a (recent) fit formula shows systematically lower values, in particular in the more realistic models with a low density. The fit is in its current form inapplicable to the new models presented here.
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| 16. |
- Sandin, Christer, et al.
(författare)
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Three-component modeling of C-rich AGB stars winds : III. Micro-physics of drift-dependent dust formation
- 2004
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Ingår i: Astronomy & Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 413, s. 789-798
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Tidskriftsartikel (refereegranskat)abstract
- A proper treatment of the non-equilibrium dust formation process is crucial in models of AGB star winds. In this paper the micro-physics of this process is treated in detail, with an emphasis on the effects of drift (drift models). We summarize the description of the dust formation process and make a few additions to previous work. A detailed study shows that different growth species dominate the grain growth rates at different drift velocities. The new models show that the net effect of drift is to significantly increase the amounts of dust, seemingly without affecting the mean wind properties, such as e.g., the mass loss rate. In some cases there is several times more dust in drift models, compared to the values in the corresponding non-drift models. We study the formation of a dust shell in the inner parts of the wind and find that drift plays an active role in accumulating dust to certain narrow regions. In view of the results presented here it is questionable if drift - under the current assumptions - can be ignored in the grain growth rates.
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| 17. |
- Sandin, Christer, et al.
(författare)
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Three-component modelling of C-rich AGB star winds - V. Effects of frequency-dependent radiative transfer including drift
- 2020
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 499:2, s. 1531-1560
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Tidskriftsartikel (refereegranskat)abstract
- Stellar winds of cool carbon stars enrich the interstellar medium with significant amounts of carbon and dust. We present a study of the influence of two-fluid flow on winds where we add descriptions of frequency-dependent radiative transfer (RT). Our radiation hydrodynamic models in addition include stellar pulsations, grain growth and ablation, gas-to-dust drift using one mean grain size, dust extinction based on both the small particle limit (SPL) and Mie scattering, and an accurate numerical scheme. We calculate models at high spatial resolution using 1024 gridpoints and solar metallicities at 319 frequencies, and we discern effects of drift by comparing drift models to non-drift models. Our results show differences of up to 1000 per cent in comparison to extant results. Mass-loss rates and wind velocities of drift models are typically, but not always, lower than in non-drift models. Differences are larger when Mie scattering is used instead of the SPL. Amongst other properties, the mass-loss rates of the gas and dust, dust-to-gas density ratio, and wind velocity show an exponential dependence on the dust-to-gas speed ratio. Yields of dust in the least massive winds increase by a factor 4 when drift is used. We find drift velocities in the range 10-67 km s(-1), which is drastically higher than in our earlier works that use grey RT. It is necessary to include an estimate of drift velocities to reproduce high yields of dust and low wind velocities.
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| 18. |
- Sandin, Christer, et al.
(författare)
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Three-component modelling of O-rich AGB star winds : I. Effects of drift using forsterite
- 2023
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 677
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Tidskriftsartikel (refereegranskat)abstract
- Stellar winds of cool and pulsating asymptotic giant branch (AGB) stars enrich the interstellar medium with large amounts of processed elements and various types of dust. We present the first study on the influence of gas-to-dust drift on ab initio simulations of stellar winds of M-type stars driven by radiation pressure on forsterite particles. Our study is based on our radiation hydrodynamic model code T-800 that includes frequency-dependent radiative transfer, dust extinction based on Mie scattering, grain growth and ablation, gas-to-dust drift using one mean grain size, a piston that simulates stellar pulsations, and an accurate high spatial resolution numerical scheme. To enable this study, we calculated new gas opacities based on the EXOMOL database, and we extended the model code to handle the formation of minerals that may form in M-type stars. We determine the effects of drift by comparing drift models to our new and extant non-drift models. Three out of four new drift models show high drift velocities, 87- 310 km s-1. Our new drift model mass-loss rates are 1.7- 13 per cent of the corresponding values of our non-drift models, but compared to the results of two extant non-drift models that use the same stellar parameters, these same values are 0.33- 1.5 per cent. Meanwhile, a comparison of other properties such as the expansion velocity and grain size show similar values. Our results, which are based on single-component forsterite particles, show that the inclusion of gas-to-drift is of fundamental importance in stellar wind models driven by such transparent grains. Assuming that the drift velocity is insignificant, properties such as the mass-loss rate may be off from more realistic values by a factor of 50 or more.
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| 19. |
- Sandin, Kenneth, et al.
(författare)
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Masonry water repellents
- 1996
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Ingår i: Durability of Building Materials and Components : Proceedings of the 7th International Conference (7DBMC,). - 0419221301 ; 1 : Prediction, degradation and materials, s. 553-561
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 20. |
- Sundström, Johan, Professor, 1971-, et al.
(författare)
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Rationale for a Swedish cohort consortium
- 2019
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Ingår i: Upsala Journal of Medical Sciences. - : Taylor & Francis Group. - 0300-9734 .- 2000-1967. ; 124:1, s. 21-28
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Tidskriftsartikel (refereegranskat)abstract
- We herein outline the rationale for a Swedish cohort consortium, aiming to facilitate greater use of Swedish cohorts for world-class research. Coordination of all Swedish prospective population-based cohorts in a common infrastructure would enable more precise research findings and facilitate research on rare exposures and outcomes, leading to better utilization of study participants' data, better return of funders' investments, and higher benefit to patients and populations. We motivate the proposed infrastructure partly by lessons learned from a pilot study encompassing data from 21 cohorts. We envisage a standing Swedish cohort consortium that would drive development of epidemiological research methods and strengthen the Swedish as well as international epidemiological competence, community, and competitiveness.
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| 21. |
- von Büllow, A., et al.
(författare)
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Severe asthma trajectories in adults: findings from the NORDSTAR cohort
- 2023
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Ingår i: European Respiratory Journal. - : European Respiratory Society. - 0903-1936 .- 1399-3003. ; 62:3
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Tidskriftsartikel (refereegranskat)abstract
- Background There is limited evidence on the pathways leading to severe asthma and we are presently unable to effectively predict the progression of the disease. We aimed to describe the longitudinal trajectories leading to severe asthma and to describe clinical events preceding disease progression in a nationwide population of patients with severe asthma.Methods We conducted an observational study based on Swedish data from the NORdic Dataset for aSThmA Research (NORDSTAR) research collaboration platform. We identified adult patients with severe asthma in 2018 according to the European Respiratory Society/American Thoracic Society definition and used latent class analysis to identify trajectories of asthma severity over a 10-year retrospective period from 2018.Results Among 169 128 asthma patients, we identified 4543 severe asthma patients. We identified four trajectories of severe asthma that were labelled as: trajectory 1 "consistently severe asthma" (n=389 (8.6%)), trajectory 2 "gradual onset severe asthma" (n=942 (20.7%)), trajectory 3 "intermittent severe asthma" (n=1685 (37.1%)) and trajectory 4 "sudden onset severe asthma" (n=1527 (33.6%)). "Consistently severe asthma" had a higher daily inhaled corticosteroid dose and more prevalent osteoporosis compared with the other trajectories. Patients with "gradual onset severe asthma" and "sudden onset severe asthma" developed type 2-related comorbidities concomitantly with development of severe asthma. In the latter group, this primarily occurred within 1-3 years preceding onset of severe asthma.Conclusions Four distinct trajectories of severe asthma were identified illustrating different patterns of progression of asthma severity. This may eventually enable the development of better preventive management strategies in severe asthma.
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