| 1. |
- Allard, Christina, et al.
(författare)
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Rasbiologiskt språkbruk i statens rättsprocess mot sameby : DN Debatt 2015-06-11
- 2015
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Annan publikation (populärvet., debatt m.m.)abstract
- Statens hantering av forskningsresultat i rättsprocessen med Girjas sameby utgör ett hot mot Sverige som rättsstat och kunskapsnation. Åratal av svensk och internationell forskning underkänns och man använder ett språkbruk som skulle kunna vara hämtat från rasbiologins tid. Nu måste staten ta sitt ansvar och börja agera som en demokratisk rättsstat, skriver 59 forskare.
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| 2. |
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| 3. |
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| 4. |
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| 5. |
- Bergman, Torbjörn, 1957-, et al.
(författare)
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Regeringsbildningen efter riksdagsvalet 2018
- 2018
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Ingår i: Snabbtänkt. - Sundsvall : DEMICOM, Mittuniversitetet. - 9789188025999 ; , s. 21-22
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Bokkapitel (populärvet., debatt m.m.)
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| 6. |
- Bergman, Torbjörn, 1957-, et al.
(författare)
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Tre tänkbara alternativ efter riksdagsvalet 2018
- 2018
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Ingår i: Västerbottens-Kuriren. - Umeå : Västerbottenskurirens Aktiebolag. - 1104-0246.
-
Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Vilka tänkbara regeringskoalitioner väntar efter riksdagsvalet? Åtminstone tre alternativ är tänkbara: För det första att blockpolitiken fortsätter på samma sätt som tidigare. Ett andra att barriären gentemot Sverigedemokraterna bryts. Ett tredje alternativ är en uppluckring av blockpolitiken. Förutsättningarna för detta förefaller större än på länge. Det skriver tre statsvetare.
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| 7. |
- Dahlin, Torleif, et al.
(författare)
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Data Quality Quantification for Time Domain IP Data Acquired along a Planned Tunnel near Oslo, Norway
- 2013
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Konferensbidrag (refereegranskat)abstract
- Tests were done measuring resistivity and time domain induced polarisation using standard multi-core cable spreads and a special layout with separate cable spreads for transmitting current and measuring potentials. For both types of cables spreads both normal and reciprocal measurements were done in order to estimate the measurement errors. The tests were done along a planned tunnel stretch outside Olso in Norway. The electrode contact was variable with resistances in the range 0.6 - 25 kΩ. The results gave low median error levels for both types of cable spreads, but the single cable spread showed a significantly larger variation with more scatter in the IP data. Data for both types of spreads gave models that are consistent and appear to delineate the complex geology in a useful way. It is concluded that the single cable spread gives surprisingly good IP data considering the large layouts at this site, which is adequate for inversion of the integrated full decay. If on the other hand the data were to be used for spectral IP inversion of the decay curves for recovering the Cole-Cole parameters the extra effort of measuring with separated cable spreads would probably be well motivated.
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| 8. |
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| 9. |
- Ebenhard, Torbjörn, et al.
(författare)
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Fåglar och Bioenergi
- 2019
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- BirdLife Europe har i skrifter publicerade tillsammans med flera andra miljöorganisationer (däribland Actionaid, An Taisce, Brot für die Welt, Carbon Market Watch, Client Earth, Dogwood Alliance, European Environmental Bureau, FERN, Greenpeace, Natural Resources Defense Council, Oxfam, Southern Environmental Law Center, Suomen luonnonsuojeluliitto, Transport & Environment, Wetlands International) framfört kritik mot viss användning av bioenergi. Denna studie började med att sammanställa dessa miljöorganisationers syn på bioenergi, baserat på deras publicerade skrifter. Syftet var inte att värdera eller bemöta alla argument för och emot bioenergi, utan mer begränsat att förstå innebörden i just den kritik som förts fram av BirdLife Europe och dem närstående miljöorganisationer. Analysen visade att dessa organisationer i grunden är positiva till bioenergi, och till att ersätta fossila bränslen med förnybara, men de skiljer mellan bra och problematiska bioenergikällor. Bra bioenergikällor är exempelvis avfall från jordbruket och träindustrin, medan alla åkergrödor och rundvirke och stubbar från skogen betraktas som problematiska källor. BirdLife Europe och de andra miljöorganisationerna är kritiska mot EU:s politik för förnybar energi. De är oroliga för att den stora ökning i tillförseln av bioenergi, som de anser måste åstadkommas för att nå de politiska målen, kommer att ge en storskalig omställning av markanvändningen, antingen här i Europa eller i tredje land, som kan ge negativa effekter på biologisk mångfald och/eller matproduktionen. BirdLife Europe och de andra miljöorganisationerna i denna studie är inte övertygade om att bioenergin löser klimatproblemet eller att den är kolneutral, och de ser en konflikt mellan målen för klimatet och målen för biologisk mångfald. De hävdar att vissa åtgärder för att nå klimatmålen kan vara skadliga för biologisk mångfald. I nästa steg intervjuades sex svenska ornitologer för att undersöka om den kritik som framförts av BirdLife Europe också delas av svenska aktörer. Även här var syftet att kartlägga attityder, inte att värdera eller bemöta alla argument för och emot bioenergi. Det framkom i intervjuerna med ornitologerna att de hyser attityder som liknar dem som förts fram av BirdLife Europe. För att minimera risker förknippade med biobränsleproduktion förespråkar respondenterna en omställning som prioriterar besparingar istället för ökad bioenergianvändning, samt ökad satsning på andra förnybara energislag. De skiljer, i likhet med Birdlife Europe, också på bra bioenergikällor, som till exempel grot och energiskogar, framför problematiska som till exempel stubbrytning och uttag av lövträd i skogslandskapet. Det framgår också att det är viktigt, givet att det sammanlagda uttaget inte ökar, att dra en skiljelinje mellan rundved/stamved från gallringar i planterade skogar, som kan användas till bioenergi, och stamved och rundvirke från slutavverkningar och från lövskogar som inte bör gå till bioenergi utan användas för andra ändamål. Av intervjuerna framkommer även en grundläggande kritik mot det trakthyggesbruk som bedrivs i stor skala i Sverige. På basis av denna kritik pekar flera av respondenterna därför på behovet – utifrån ett fågelperspektiv - av att öka andelen flerskiktad skog, och därmed ersätta trakthyggesbruket med någon form av hyggesfritt skogsbruk. I en kampanjskrift mot bioenergi ”The Black Book of Bioenergy – Good intentions gone bad”, presenterar Birdlife Europe ett antal landstudier där de menar att uttagen av biomassa för energiändamål har gått för långt. Ett av dessa exempel är Finland där de skriver att bioenergiindustrin skövlar de ikoniska finska skogarna ned till sista stubben. Objektivt speglande mot finsk skogs- och avverkningsstatistik visar att uttagsnivåerna av grot, klena stammar och stubbar fortfarande är förhållandevis måttliga i relation till de avverkningar som görs för att leverera stamved till den traditionella skogsindustrin. Givet att detta är nationella data kan det emellertid inte uteslutas att intensiteten kring tätorter med stort behov av el och värme kan vara ganska hög. Data som presenteras i texten i övrigt stämmer väl överens med officiella data – men är skrivna på ett sätt som antyder att bioenergimarknadens påverkan på de finska skogarna redan är mycket stor. En slutsats från vår sida är att de finska skogarna i första hand påverkas av avverkningar för att leverera stamved till den traditionella skogsindustrin. Samhällsdebatten kring bioenergin är starkt polariserad mellan miljöorganisationer, areella näringar, energiföretag, politiker, olika forskare och andra aktörer. Den argumentation som framförs av olika opinionsbildare är ofta konfrontativ och förenklad. De ofta motsatta ståndpunkter som nu framförs i debatten bottnar till stor del i olika utgångspunkter och olika antaganden om nuvarande och framtida förhållanden, snarare än i oenigheter om mätbara storheter. I studiens avslutande del gjordes en litteraturöversikt över kunskapen om hur tillförseln av bioenergi i Sverige påverkar fågelfaunan. Denna kunskapsöversikt adresserar en viss del av den kritik som förts fram av BirdLife Europe och av de intervjuade ornitologerna, medan andra delar ej berörs, t.ex. bioenergins klimateffekter eller effekter på annan biologisk mångfald än fåglar. Ett grundläggande problem i kunskapsöversikten var att särskilja effekter av bioenergitillförsel från effekter av skogsbruk och jordbruk i allmänhet. Det som eftersöktes var alltså effekter av t.ex. uttag av skogsbränsle, utöver de effekter skogsbruket i sig ger på fågelfaunan. Som baseline för analysen användes därför en tänkt markanvändning utan uttag av biomassa för energiändamål, t.ex. normalt skogsbruk på skogsmark inriktat mot sågtimmer och massaved, eller normalt åkerbruk. Den tillgängliga litteraturen är mycket knapphändig när det gäller effekter på fågelfaunan av skogsbränsleuttag i form av grot, stubbar, rundvirke eller gallringsvirke. Det finns inga direkta studier på bestånds- eller landskapsnivå av enstaka arter eller hela fågelsamhället. Fåglarna skulle kunna påverkas av att mängden död ved minskar vid uttag av skogsbränsle, och att vegetationens struktur ändras av gallring, röjning och slytäkt. Detta skulle kunna ge brist på lämplig häckningsbiotop och föda. För denna studie gjorde vi ett urval bestående av 146 svenska häckfågelarter som potentiellt kan påverkas av biobränsleproduktion i jord- och skogsbruket. Ett stort antal fågelarter påverkas av slutavverkningar, speciellt om de blir omfattande på landskapsnivå, men det bör påpekas att endast en mycket liten andel av rundvirket används direkt för energiändamål idag. Av de 103 fågelarter som klassificerats som skogsarter är det 46 arter som regelbundet förekommer på hyggen och 57 arter som inte gör det. Förväntningarna var att arter som regelbundet förekommer på hyggen skulle uppvisa en mer positiv populationsutveckling än övriga arter, men mönstret var snarast det motsatta. Av de arter som undviker hyggen uppvisar 44 % positiv populationsutveckling (1996-2016), medan endast 9 % uppvisar negativ populationsutveckling. Många av dessa 57 arter som undviker hyggen är knutna till yngre skogar och tycks klara sig bra i det moderna skogslandskapet. Fyrtiosex av de 103 skogsarterna förekommer regelbundet på hyggen och 22 % av dessa uppvisar positiv populationsutveckling och 22 % uppvisar negativ populationsutveckling. Trots de omfattande effekterna av hyggesbruket på fågelfaunan har det inte gått att påvisa uttalat negativa effekter på de nationella populationstrenderna för arter som undviker hyggen, arter som är kopplade till lövskogar eller för arter som är beroende av död ved och gamla träd. Det finns få studier som visar hur olika skogsarter påverkas av gallringar, men de som finns tyder på att tätheten av fåglar i gallrade skogar är lägre än i ogallrade skogar. Av de 103 skogsarterna har 30 klassats som knutna till tät skog (eller buskage) ofta med stort inslag av lövträd och dessa kan förväntas påverkas negativt av gallring. Endast tre (10 %) av dessa 30 arter har minskande populationer, medan nio arter (30 %) har ökande populationer, vilket tyder på att de flesta arters populationer inte tycks ha påverkats negativt på nationell nivå. Det tycks alltså som om dessa arter klarar sig relativt bra i det moderna brukade skogslandskapet, även om flera arter med stor sannolikhet drabbats negativt lokalt av gallringar av skogsbestånd. Gallringar för uttag av biobränslen görs idag i begränsad omfattning, mindre än en procent av den bioenergi som producerades 2015 kom från klena stammar från röjningar och gallringar. Effekterna av detta på fågelfaunan torde vara begränsade. Effekten av uttag av grot på olika fågelarter i samband med avverkning är dåligt studerad. Uttag av grenar och toppar gör att hyggena förlorar strukturer som kan erbjuda skyddade boplatser för markhäckande fågelarter. Det normala förfarandet vid grotskörd är att grot läggs i små högar på hygget under första sommaren medan groten lämnas mer spridd och inte sällan i körvägen då den inte skördas. Om denna skillnad har betydelse för fåglar är okänt. Tjugo av de 146 fågelarterna har bedömts preferera hyggen och placerar sitt bo på marken och kan potentiellt påverkas av uttag av grot, även om effekten av kvarlämnad grot kan var kortvarig pga. nedbrytning. Förekomsten av avverkningsrester gynnar många ryggradslösa djur, som utgör potentiell föda för fåglar, särskilt många tättingar. Kraftigt minskad tillgång på skyddade småmiljöer på hygget missgynnar smågnagare som är föda för ugglor o
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| 11. |
- Engstrand, Per, 1955-, et al.
(författare)
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Improved refining energy efficiency in thermo-mechanical pulping by means of collimated wood chipping – from solid mechanics to full scale evaluation
- 2016
-
Ingår i: PaperWeek Canada 2016 Conference <em>February 1 to 5, 2016, Montreal</em>.
-
Konferensbidrag (refereegranskat)abstract
- The wood chipping process was never optimized with regard to high yield pulping processes as thermomechanical pulping (TMP) and chemithermomechanical pulping (CTMP). It is generally believed that wood chips for pulping should be produced in such a way that the degree of damage is minimized and that the chip dimensional distribution should be as narrow as possible. Since the TMP and CTMP processes were developed in the 60-ies and 70-ies, compression screw as well as roll nip equipment have been developed to pretreat wood chips as a way to reduce refining energy consumption to given fiber and pulp properties and also in order to improve impregnation. The general conclusions are that a combination of shear and compression in the tangential or radial direction of the wood initiates cracks that later in the refiner will enhance and optimize fiber separation and also fiber property development. The idea with the collimated chipping technology is to utilize the wood chipper as a tool, combining cutting of wood logs to wood chips with a pretreatment of the chips by creating cracks that would enhance fiber separation, fiber surface development as well as chip-impregnation. In this case the compression is performed in the wood fiber direction, in which direction wood actually is weakest when it comes to compression induced cracking. The maximization of the amount of cracks in wood-chips is performed by optimizing the knife angle (or spout angle) in the chipper, to what we call collimated chipping (according to a patent owned by CCT AB). This presentation describes a theoretical background and two demonstration scale studies performed by SCA Forest Products at their Ortviken mill. One conclusion drawn, based on two-month test period with three weeks of collimated chipping, was that specific refining energy reduction was around 100 kWh/adt of the 1400 kWh/adt used in primary stage double disc refining. Most probably the potential is higher if the whole system is optimized. Tests were performed at constant production rate and energy was reduced by reducing power to constant freeness, leading to similar tensile and light scattering levels. The deliberately increased forces created in the wood chipper by means of an optimized (increased) edge angle caused more problems with knife holder equipment than normally, as well as increased vibrations. These problems will have to be solved for future long-term implementation of the technique.
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| 12. |
- Lahdenperä, Pirjo, 1949-, et al.
(författare)
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Forskningscirkel - arena för verksamhetsutveckling i mångfald
- 2011
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Rapport (refereegranskat)abstract
- Forskningscirkel arena för verksamhetsutveckling i mångfald är en slutrapport av forskningscirkelarbetet inom projektet JämBredd, 2009-2011. I antologin presenteras projektet teoretiska referensram med mångfald, intersektionalitet och interkulturalitet samt erfarenheter av forskningscirkelarbetet i skola, förskola, omsorg, service och arbetslivet. Tio olika forskare från Mälardalens högskola har lett varsin forskningscirkel och skrivit om sina erfarenheter i olika kapitel. Antologin ger en bred bild av interkulturell verksamhetsnära forskning.
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| 13. |
- Lestander, Torbjörn, et al.
(författare)
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Characterization of fast pyrolysis bio-oil properties by near-infrared spectroscopic data
- 2018
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Ingår i: Journal of Analytical and Applied Pyrolysis. - : Elsevier BV. - 0165-2370 .- 1873-250X. ; 133, s. 9-15
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Tidskriftsartikel (refereegranskat)abstract
- Pyrolysis transforms bulky and heterogeneous lignocellulosic biomass into more easily-handled oils that can be upgraded into bio-based transportation fuels. Existing systems for monitoring pyrolysis processes and characterizing their products rely on slow and time-consuming wet chemical analyses. On-line near-infrared (NIR) spectroscopy could potentially replace such analyses, providing real-time data and reducing costs. To test the usefulness of NIR methods in characterizing pyrolysis oils and processes, biomass from conifers, Salix, and reed canary grass was milled and pyrolyzed at 675, 750, and 775 °C. Two separate pyrolytic fractions (aerosol and condensed) were produced in each experiment, and NIR spectra were collected for each fraction. Multivariate modelling of the resulting data clearly showed that the samples’ NIR spectra could be used to accurately predict important properties of the pyrolysis oils such as their energy values, main organic element (C, H and O) contents, and water content. The spectra also contained predictive information on the samples’ origins, fraction, and temperature treatment, demonstrating the potential of on-line NIR techniques for monitoring pyrolytic production processes and characterizing important properties of pyrolytic oils from lignocellulosic biomass.
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| 14. |
- Liberg, Olof, et al.
(författare)
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Så kan vargstammen räddas
- 2010
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Ingår i: Dagens nyheter. - 1101-2447.
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Tidskriftsartikel (populärvet., debatt m.m.)
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| 15. |
- Lundqvist, Anette, 1963-
(författare)
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Nutritional aspects of behaviour and biology during pregnancy and postpartum
- 2016
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- BackgroundA well-balanced nutritious diet is important for the pregnant woman and the growing fetus, as well as for their future health. Poor nutrition results from both over-consumption of energy-rich foods which can lead to a higher weight gain than is healthy and under-nutrition of essential nutrients. Food intake is regulated in complex biological systems by many factors, where steroid hormone is one factor involved.The overall aim of this thesis is to describe dietary intake, vitamin D levels, dietary information and dietary changes, and to study the relation between allopregnanolone and weight gain during pregnancy and postpartum.Methods Study I was a qualitative study with focus group interviews with 23 pregnant women. The text was analysed with content analysis. Study II was a quantitative cross-sectional study conducted in early pregnancy (n=209) with a reference group (n=206). Self-reported dietary data from a questionnaire was analysed using descriptive comparative statistics and a cluster analysis model (Partial Least Squares modelling). Study III had a quantitative longitudinal design. Vitamin D concentrations were analysed in 184 women, collected on five occasions during pregnancy and postpartum. Descriptive comparative statistics and a linear mixed model were used. Study IV was a quantitative longitudinal study with 60 women. Concentrations of allopregnanolone were analysed in gestational week 12 and 35. Descriptive and comparative statistics as well as Spearman’s correlation (rho) were used to describe the relationship between weight gain and allopregnanolone concentrations. Results The focus group interviews showed that women wanted to know more about different foods to reduce any risk for their child but the information about foods was partly up to themselves to find out. They expressedfeelingsof insecurityand guiltif they accidentallyate something“forbidden”. The recommendationswere followedas best as possiblealong withcommon sense todeal with dietchanges. The main themes were “Finding out by oneself”, “Getting professional advice when health problems occur”, “Being uncertain” and “Being responsible with a pinch of salt”. Some differences in the dietary patterns were found among the pregnant women compared to references, with less, vegetables (47 g/day), potatoes/rice/pasta (31 g/day), meat/fish (24 g/day) and intake of alcohol and tobacco/snuff but a higher intake of supplements. Bothpregnant women and referenceshad intakes offolatethrough diet45% (pregnant) and 22% (references) lower than current recommendations(500vs400g/day). Vitamin Dintake was34% lower than the recommendationsof 10mg/day. At least a third of the participants had insufficient plasma levels below 50 nmol/L of vitamin D. Season was a strong factor influencing the longitudinal pattern. Gestational week, season, total energy intake, dietary intake of vitamin D, and multivitamin supplementation over the previous 14 days were factors related to vitamin D levels. A correlation betweenallopregnanoloneconcentrations ingestationalweek 35and weight gainin weeks12–35was seen (p = 0.016). Therewas alsoa correlation betweenthe increase inallopregnanolone(weeks12–35) andweight gain(see above) (p = 0.028). ConclusionsDietary recommendations were described as contradictory and confusing and the dietary advice felt inadequate. The women faced their diet changes and sought information on their own but would have wished for more extensive advice from the midwife. The intake of vitamins essential for pregnancy was lower than recommended, which is also confirmed by low plasma levels of vitamin D in at least one third of the pregnant women. Vitamin D levels peaked in late pregnancy. Aside from gestational week and season which were related to plasma levels, intake from foods and supplements also affected the levels. Reasons for weight gain are complex and depend on many factors. Allopregnanolone is a factor that was seen to relate to the weight gain of the studied pregnant women.
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| 16. |
- Lundqvist, Anette, et al.
(författare)
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The relationship between weight gain during pregnancy and allopregnanolone levels : a longitudinal study
- 2017
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Ingår i: Endocrine Connections. - : Bioscientifica. - 2049-3614. ; 6:4, s. 253-259
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Tidskriftsartikel (refereegranskat)abstract
- Objective: Large weight gain during pregnancy is a risk factor for complications for mother and fetus. Hunger and satiety are regulated in the hypothalamus, where the gamma-amino-butyric acid system (GABA) has an important role. Allopregnanolone, a progesterone metabolite, increases during pregnancy and is a potent GABA-A receptor modulating steroid. Allopregnanolone has been shown to induce overeating in rodents. The aim was to investigate whether there is a relationship between weight gain and allopregnanolone concentrations during pregnancy in humans. Design: A longitudinal, cohort study. Methods: Pregnant women (n = 56) were recruited in primary care in northern Sweden. Allopregnanolone concentrations in plasma were measured using radioimmunoassay and weight was measured in gestational weeks 12 and 35. Results: Weight increase correlated significantly to allopregnanolone in late pregnancy increase (r(s) = 0.320; P = 0.016), indicating a positive relationship between weight increase and allopregnanolone increase. A positive relationship was also noted between allopregnanolone in the 35th gestational week and weight increase. Women who gained = 11 kg during pregnancy showed higher allopregnanolone concentrations in week 35 and higher increase compared to women who increased < 11 kg (P = 0.006 and P = 0.009 resp.). There was no difference in weight or allopregnanolone concentrations at the onset of pregnancy. Conclusions: The results show a relationship between weight gain during pregnancy and increase in allopregnanolone concentrations.
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| 17. |
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| 18. |
- Mitran, Bogdan, et al.
(författare)
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Evaluation of Tc-99m-Z(IGF1R:4551)-GGGC affibody molecule, a new probe for imaging of insulin-like growth factor type 1 receptor expression
- 2015
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Ingår i: Amino Acids. - : Springer Science and Business Media LLC. - 0939-4451 .- 1438-2199. ; 47:2, s. 303-315
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Tidskriftsartikel (refereegranskat)abstract
- Overexpression of insulin-like growth factor-1 receptor (IGF-1R) in several cancers is associated with resistance to therapy. Radionuclide molecular imaging of IGF-1R expression in tumors may help in selecting the patients that will potentially respond to IGF-1R-targeted therapy. Affibody molecules are small (7 kDa) non-immunoglobulin-based scaffold proteins that are well-suited probes for radionuclide imaging. The aim of this study was the evaluation of an anti-IGF-1R affibody molecule labeled with technetium-99m using cysteine-containing peptide-based chelator GGGC at C-terminus. Z(IGF1R:4551)-GGGC was efficiently and stably labeled with technetium-99m (radiochemical yield 97 +/- A 3 %). Tc-99m-Z(IGF1R:4551)-GGGC demonstrated specific binding to IGF-1R-expressing DU-145 (prostate cancer) and MCF-7 (breast cancer) cell lines and slow internalization in vitro. The tumor-targeting properties were studied in BALB/c nu/nu mice bearing DU-145 and MCF-7 xenografts. [Tc-99m(CO)(3)](+)-(HE)(3)-Z(IGF1R:4551) was used for comparison. The biodistribution study demonstrated high tumor-to-blood ratios (6.2 +/- A 0.9 and 6.9 +/- A 1.0, for DU-145 and MCF-7, respectively, at 4 h after injection). Renal radioactivity concentration was 16-fold lower for Tc-99m-Z(IGF1R:4551)-GGGC than for [Tc-99m(CO)(3)](+)-(HE)(3)-Z(IGF1R:4551) at 4 h after injection. However, the liver uptake of Tc-99m-Z(IGF1R:4551)-GGGC was 1.2- to 2-fold higher in comparison with [Tc-99m(CO)(3)](+)-(HE)(3)-Z(IGF1R:4551). A possible reason for the elevated hepatic uptake of Tc-99m-Z(IGF1R:4551)-GGGC is a high lipophilicity of amino acids in the binding site of Z(IGF1R:4551), which is not compensated in Tc-99m-Z(IGF1R:4551)-GGGC. In conclusion, Tc-99m-Z(IGF1R:4551)-GGGC can visualize the IGF-1R expression in human tumor xenografts and provides low retention of radioactivity in kidneys. Further development of this imaging agent should include molecular design aimed at reducing the hepatic uptake.
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| 19. |
- Moberg, Christina, et al.
(författare)
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De unga gör helt rätt när de stämmer staten
- 2022
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Ingår i: Aftonbladet. - 1103-9000.
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- 1 620 forskare och lärare i forskarvärlden: Vi ställer oss bakom Auroras klimatkrav
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| 20. |
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Människan i skogen, skogen i människan : Miun Research Exhibition
- 2021
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Konstnärligt arbeteabstract
- Med utställningen Människan i skogen, skogen i människan vill projektet belysa ett antal aktuella och viktiga frågor för vår region och samtid, samlade under ett tema: skog och hållbar utveckling. I utställningen får besökaren möta kunskap och perspektiv från fem forskare och forskargrupper vid Mittuniversitetet. Forskarna är verksamma inom biologi, ekoteknik, historia, litteraturvetenskap respektive turismvetenskap. Forskningens olika perspektiv länkas i utställningen samman genom sina förhållningssätt till tid, såsom avgörande för förståelse, kunskap och handling. De olika forskningsinriktningarna visar också fram spänningar mellan olika synsätt på skog och kan tillsammans ge flera svar och berättelser om skogens värden. En arbetsgrupp vid Universitetsbiblioteket står för gestaltning och produktion av utställningen.
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| 21. |
- Orlova, Anna, et al.
(författare)
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[99mTc(CO)3]+-(HE)3-Z IGF1R45514551 : a new Affibody conjugate for visualization of insulin-like growth factor-1 receptor expression in malignant tumours.
- 2013
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Ingår i: European Journal of Nuclear Medicine and Molecular Imaging. - : Springer Science and Business Media LLC. - 1619-7070 .- 1619-7089. ; 40:3, s. 439-449
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: Radionuclide imaging of insulin-like growth factor type 1 receptor (IGF-1R) expression in tumours might be used for selection of patients who would benefit from IGF-1R-targeted therapy. We have previously shown the feasibility of IGF-1R imaging using the Affibody molecule (111)In-DOTA-His(6)-Z(IGF1R:4551). The use of (99m)Tc instead of (111)In should improve sensitivity and resolution of imaging, and reduce the dose burden to patients. We hypothesized that inclusion of a HEHEHE tag instead of a His(6) tag in Z(IGF1R:4551) would permit its convenient purification using IMAC, enable labelling with [(99m)Tc(CO)(3)](+), and improve its biodistribution. METHODS: Z(IGF1R:4551) was expressed with a HEHEHE tag in the N terminus. The resulting (HE)(3)-Z(IGF1R:4551) construct was labelled with [(99m)Tc(CO)(3)](+). Targeting of IGF-1R-expressing cells using [(99m)Tc(CO)(3)](+)-(HE)(3)-Z(IGF1R:4551) was evaluated in vitro and in vivo. RESULTS: (HE)(3)-Z(IGF1R:4551) was stably labelled with (99m)Tc with preserved specific binding to IGF-1R-expressing DU-145 prostate cancer cells in vitro. In mice, [(99m)Tc(CO)(3)](+)-(HE)(3)-Z(IGF1R:4551) accumulated in IGF-1R-expressing organs (pancreas, stomach, lung and salivary gland). [(99m)Tc(CO)(3)](+)-(HE)(3)-Z(IGF1R:4551) demonstrated 3.6-fold lower accumulation in the liver and spleen than (111)In-DOTA-Z(IGF1R:4551). In NMRI nu/nu mice with DU-145 prostate cancer xenografts, the tumour uptake was 1.32 ± 0.11 %ID/g and the tumour-to-blood ratio was 4.4 ± 0.3 at 8 h after injection. The xenografts were visualized using a gamma camera 6 h after injection. CONCLUSION: (99m)Tc(CO)(3)](+)-(HE)(3)-Z(IGF1R:4551) is a promising candidate for visualization of IGF-1R expression in malignant tumours.
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| 22. |
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| 23. |
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| 24. |
- Sandström, Anton, et al.
(författare)
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Altered GABAA receptor function in women with endometriosis : a possible pain-related mechanism
- 2023
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Ingår i: Acta Obstetricia et Gynecologica Scandinavica. - : John Wiley & Sons. - 0001-6349 .- 1600-0412. ; 102:10, s. 1316-1322
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: The mechanism underlying endometriosis-related pain remains poorly understood. Previous studies have indicated that γ-aminobutyric acid (GABA) type A (GABAA) receptors and GABAergic substances (eg endogenous neurosteroids) play important mechanistic roles in various pain conditions. Our primary objective was to compare GABAA receptor function between women with endometriosis and healthy controls by performing a challenge test with diazepam, a GABAA receptor agonist, using the saccadic eye velocity as the main outcome. The secondary objective was to investigate the relationship between GABAA receptor function and serum levels of allopregnanolone, an endogenous positive modulator of the GABAA receptor, in the participating women.Material and methods: 15 women with pelvic pain and laparoscopically confirmed endometriosis and 10 healthy, symptom-free, control women, aged 18–40 years, underwent the diazepam challenge test during the follicular phase of the menstrual cycle. Basal serum allopregnanolone levels were measured prior to diazepam injection.Results: Compared with healthy controls, women with pelvic pain and confirmed endometriosis had a significantly smaller change in saccadic eye velocity after GABAA receptor stimulation with diazepam, indicating lower sensitivity to diazepam. The saccadic eye velocity response was not correlated with the serum allopregnanolone levels.Conclusions: Women with painful endometriosis show altered GABAA receptor function, depicted as a muted response to an exogenous GABAA receptor agonist.
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| 25. |
- Sandström, Anton, et al.
(författare)
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Effect of hysterectomy on pain in women with endometriosis : a population-based registry study
- 2020
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Ingår i: British Journal of Obstetrics and Gynecology. - : John Wiley & Sons. - 1470-0328 .- 1471-0528. ; 127:13, s. 1628-1635
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To assess pain symptoms before and after hysterectomy in women with endometriosis.Design: A population-based registry study.Setting: Sweden.Population: Women aged 18-45 years who underwent hysterectomy for endometriosis between 2010 and 2015.Methods: Pain symptoms before hysterectomy and 12 months after surgery were collected from the Swedish National Quality Register for Gynaecological Surgery (GynOp). Pain symptoms were also assessed by follow-up surveys after a median follow-up period of 63 months.Main outcome measures: Pelvic or lower abdominal pain after hysterectomy.Results: The study included 137 women. The proportion of women experiencing pain of any severity decreased by 28% after hysterectomy (P < 0.001). The proportion of women with severe pain symptoms decreased by 76% after hysterectomy (P < 0.001). The majority of women (84%) were satisfied with the surgical result. Presence of severe pain symptoms after the hysterectomy was associated with less satisfaction (P < 0.001). Pain symptoms after surgery, patient satisfaction and the patient's perceived improvement were not significantly different between women whose ovarian tissue was preserved and women who underwent bilateral oophorectomy.Conclusions: We observed a significant, long-lasting reduction in pain symptoms after hysterectomy among women with endometriosis. Hysterectomy, with the possibility of ovarian preservation, may be a valuable option for women with endometriosis who suffer from severe pain symptoms.Tweetable abstract: Hysterectomy is a valuable option for women with endometriosis and severe pain symptoms.
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| 26. |
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| 27. |
- Sauma, Lilian, et al.
(författare)
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Isolated primary human visceral fat cells release more angiotensin II than subcutaneous adipocytes
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Background. Visceral obesity relates strongly to the metabolic syndrome and hence to hypertension. Although a local renin-angiotensin-system (RAS) in fat tissue is known, very few studies have dealt with RAS in isolated primary human fat cells, in particular from the visceral compartment. Methods. Measurement of angiotensin II (Ang II) in medium from isolated primary human fat cells from visceral and subcutaneous adipose tissues and analyses of RAS-components in human fat cells and fat tissues. Results. Primary human fat cells from omental adipose tissue produced more Ang II than subcutaneous cells. Treatment with insulin did not affect Ang II production and body-massindex of the fat-donors was unrelated to Ang II production. The PPAR gamma agonist rosiglitazone inhibited Ang II production in both types of isolated fat cells while addition of the Ang II receptor antagonist eprosartan inhibited the production in only subcutaneous fat cells. Addition of 50 or 200 nM of Ang II inhibited the PPAR gamma response elementactivity (PPRE-activity) in visceral, but not in the subcutaneous adipocytes. Conclusions. Since high PPRE-activity induced by rosiglitazone inhibited the Ang II production, it is possible that reduced PPRE-activity in the visceral human fat cells, demonstrated by us earlier, can explain the comparatively high Ang II production in these cells. This could form the basis for a local paracrine viscous circle in visceral fat where low PPRE-activity increases Ang II production that is further enhanced by Ang II-mediated inhibition of PPRE-activity which ultimately leads to high concentrations of Ang II in human adipose tissue.
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| 28. |
- Sundberg, Torbjörn, et al.
(författare)
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Small recoverable payload for deployable sounding rocket experiments
- 2009
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Ingår i: Proceedings of the 19th Esa Symposium on European Rocket and Balloon Programmes and Related Research. - 9789292212353 ; , s. 281-284
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Konferensbidrag (refereegranskat)abstract
- We present a design of a small payload for deployment from sounding rockets. The payload is intended for measurements in the ionosphere and the acquired data is stored onboard. For a secure recovery of the data and possible re-use of the payload, an inflatable structure is deployed during the payload descent. This reduces the payload speed and protects it from ground impact. On the ground, a localization system is activated, sending the payload position via a satellite link, and providing a radio beacon signal. The proposed small payload will allow high time resolution multipoint measurements in the ionosphere with small separation distances, thus allowing to address a number of unresolved questions in the field.
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| 29. |
- Söderberg, Lotta, et al.
(författare)
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A Validation Study of an Interviewer-Administered Short Food Frequency Questionnaire in Assessing Dietary Vitamin D and Calcium Intake in Swedish Children
- 2017
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Ingår i: Nutrients. - : MDPI AG. - 2072-6643. ; 9:7
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Tidskriftsartikel (refereegranskat)abstract
- Vitamin D and calcium are essential nutrients with a range of biological effects of public health relevance. This study aimed to validate a short food frequency questionnaire (SFFQ) against a three-day food record (3D record), assessing the intake of vitamin D and calcium in Swedish children during wintertime. In a double-blinded, randomized food-based intervention study on the effect of feeding different daily doses of vitamin D supplement to 5-7-year-old children (n = 85), 79 (93%) participants completed SFFQ1 at baseline and SFFQ2 after the intervention, and 72 were informed to fill in a 3D record. The 28 (39%) children who completed the 3D record were included in this validation study. The baseline level of serum-25 hydroxy vitamin D [S-25(OH)D] was used as a biomarker. The correlation between all three instruments were moderate to strong. SFFQ2 and the 3D record correlated moderately to S-25(OH)D. Bland-Altman analysis showed that SFFQ2 overestimated vitamin D intake by on average 0.6 mu g/day, (limits of agreement (LOA) 5.7 and -4.6 mu g/day), whereas the intake of calcium was underestimated by on average 29 mg/day, (LOA 808 and -865 mg/day). Finally, the validity coefficient calculated for vitamin D using the method of triad was high (0.75). In conclusion, this SFFQ, assessed by a dietician, is a valid tool to assess dietary vitamin D and calcium intake in groups of young children.
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| 30. |
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| 31. |
- Tolmachev, Vladimir, et al.
(författare)
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Imaging of Insulinlike Growth Factor Type 1 Receptor in Prostate Cancer Xenografts Using the Affibody Molecule (111)In-DOTA-Z(IGF1R:4551)
- 2012
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Ingår i: Journal of Nuclear Medicine. - : Society of Nuclear Medicine. - 0161-5505 .- 1535-5667 .- 2159-662X. ; 53:1, s. 90-97
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Tidskriftsartikel (refereegranskat)abstract
- One of the pathways leading to androgen independence in prostate cancer involves upregulation of insulinlike growth factor type 1 receptor (IGF-1R). Radionuclide imaging of IGF-1R in tumors might be used for selection of patients who would most likely benefit from IGF-1R-targeted therapy. The goal of this study was to evaluate the feasibility of in vivo radionuclide imaging of IGF-1R expression in prostate cancer xenografts using a small nonimmunoglobulin-derived binding protein called an Affibody molecule. Methods: The IGF-1R-binding Z(IGF1R:4551) Affibody molecule was site-specifically conjugated with a maleimido derivative of DOTA and labeled with (111)In. The binding of radiolabeled Z(IGF1R:4551) to IGF-1R-expressing cells was evaluated in vitro and in vivo. Results: DOTA-Z(IGF1R:4551) can be stably labeled with (111)In with preserved specific binding to IGF-1R-expressing cells in vitro. In mice, (111)In-DOTAZ(IGF1R):(4551) accumulated in IGF-1R-expressing organs (pancreas, stomach, lung, and salivary gland). Receptor saturation experiments demonstrated that targeting of DU-145 prostate cancer xenografts in NMRI nu/nu mice was IGF-1R-specific. The tumor uptake was 1.1 +/- 0.3 percentage injected dose per gram, and the tumor-to-blood ratio was 3.2 +/- 0.2 at 8 h after injection. Conclusion: This study demonstrates the feasibility of in vivo targeting of IGF-1R-expressing prostate cancer xenografts using an Affibody molecule. Further development of radiolabeled Affibody molecules might provide a useful clinical tool for stratification of patients with prostate cancer for IGF-1R-targeting therapy.
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| 32. |
- Åman, Johan, et al.
(författare)
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Recent developments in large-area photomasks for display applications
- 2001
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Ingår i: Journal of the Society for Information Display. - San Jose, CA : Wiley. - 1071-0922. ; 9:1, s. 3-8
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Tidskriftsartikel (refereegranskat)abstract
- One of the most critical areas in the manufacturing process for FPD panels or shadow masks for CRTs is lithography. Most existing lithography technologies require high-quality large-area photomasks. The requirements on these photomasks include positioning accuracy (registration) and repeatability (overlay), systematic image quality errors ("mura" or display quality), and resolution (minimum feature size). The general trend toward higher resolution and improved performance, e.g., for TFT desktop monitors, has put a strong focus on the specifications for large-area-display photomasks. This article intends to give an overview of the dominant issues for large-area-display photomasks, and illustrates differences compared with other applications. The article will also present state-of-the-art methods and trends. In particular, the aspects of positioning accuracy over large areas and systematic image-quality errors will be described. New qualitative and objective methods have been developed as means to capture systematic image-quality errors. Results indicating that errors below 25 nm can be found early in the manufacturing process is presented, thus allowing inspection for visual effects before the actual display is completed. Positioning accuracy below 400 nm (3 sigma) over 720 × 560 mm have been achieved. These results will in the future be extended up toward 1 × 1 m for generation 4 in TFT-LCD production.
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