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  • Ellison, Stephen, et al. (author)
  • Attenuation of Experimental Atherosclerosis by Interleukin-19.
  • 2013
  • In: Arteriosclerosis, Thrombosis and Vascular Biology. - 1524-4636. ; 33:10, s. 2316-2324
  • Journal article (peer-reviewed)abstract
    • Interleukin-19 (IL-19) is a putative Th2, anti-inflammatory interleukin. Its expression and potential role in atherogenesis are unknown. IL-19 is not detected in normal artery and is expressed to a greater degree in plaque from symptomatic versus asymptomatic patients, suggesting a compensatory counter-regulatory function. We tested whether IL-19 could reduce atherosclerosis in susceptible mice and identified plausible mechanisms.
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