| 1. |
- Hatos, Andras, et al.
(författare)
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DisProt : intrinsic protein disorder annotation in 2020
- 2020
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Ingår i: Nucleic Acids Research. - : Oxford University Press (OUP). - 0305-1048 .- 1362-4962. ; 48:D1, s. D269-D276
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Tidskriftsartikel (refereegranskat)abstract
- The Database of Protein Disorder (DisProt, URL:https://disprot.org) provides manually curated annotations of intrinsically disordered proteins from the literature. Here we report recent developments with DisProt (version 8), including the doubling of protein entries, a new disorder ontology, improvements of the annotation format and a completely new website. The website includes a redesigned graphical interface, a better search engine, a clearer API for programmatic access and a new annotation interface that integrates text mining technologies. The new entry format provides a greater flexibility, simplifies maintenance and allows the capture of more information from the literature. The new disorder ontology has been formalized and made interoperable by adopting the OWL format, as well as its structure and term definitions have been improved. The new annotation interface has made the curation process faster and more effective. We recently showed that new DisProt annotations can be effectively used to train and validate disorder predictors. We believe the growth of DisProt will accelerate, contributing to the improvement of function and disorder predictors and therefore to illuminate the 'dark' proteome.
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| 2. |
- Piovesan, Damiano, et al.
(författare)
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DisProt 7.0 : a major update of the database of disordered proteins
- 2017
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Ingår i: Nucleic Acids Research. - : Oxford University Press (OUP). - 0305-1048 .- 1362-4962. ; 45:D1, s. d219-D227
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Tidskriftsartikel (refereegranskat)abstract
- The Database of Protein Disorder (DisProt, URL: www.disprot.org) has been significantly updated and upgraded since its last major renewal in 2007. The current release holds information on more than 800 entries of IDPs/IDRs, i.e. intrinsically disordered proteins or regions that exist and function without a well-defined three-dimensional structure. We have re-curated previous entries to purge DisProt from conflicting cases, and also upgraded the functional classification scheme to reflect continuous advance in the field in the past 10 years or so. We define IDPs as proteins that are disordered along their entire sequence, i.e. entirely lack structural elements, and IDRs as regions that are at least five consecutive residues without well-defined structure. We base our assessment of disorder strictly on experimental evidence, such as X-ray crystallography and nuclear magnetic resonance ( primary techniques) and a broad range of other experimental approaches (secondary techniques). Confident and ambiguous annotations are highlighted separately. DisProt 7.0 presents classified knowledge regarding the experimental characterization and functional annotations of IDPs/IDRs, and is intended to provide an invaluable resource for the research community for a better understanding structural disorder and for developing better computational tools for studying disordered proteins.
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| 3. |
- Quaglia, Federica, et al.
(författare)
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DisProt in 2022 : improved quality and accessibility of protein intrinsic disorder annotation
- 2022
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Ingår i: Nucleic Acids Research. - : Oxford University Press (OUP). - 0305-1048 .- 1362-4962. ; 50:D1, s. D480-D487
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Tidskriftsartikel (refereegranskat)abstract
- The Database of Intrinsically Disordered Proteins (DisProt, URL: https://disprot.org) is the major repository of manually curated annotations of intrinsically disordered proteins and regions from the literature. We report here recent updates of DisProt version 9, including a restyled web interface, refactored Intrinsically Disordered Proteins Ontology (IDPO), improvements in the curation process and significant content growth of around 30%. Higher quality and consistency of annotations is provided by a newly implemented reviewing process and training of curators. The increased curation capacity is fostered by the integration of DisProt with APICURON, a dedicated resource for the proper attribution and recognition of biocuration efforts. Better interoperability is provided through the adoption of the Minimum Information About Disorder (MIADE) standard, an active collaboration with the Gene Ontology (GO) and Evidence and Conclusion Ontology (ECO) consortia and the support of the ELIXIR infrastructure.
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| 4. |
- Schad, Elinor, et al.
(författare)
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Elevers utveckling under skolåren
- 2014
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Ingår i: Evidensbaserad elevhälsa. - 9789144089690 ; , s. 191-204
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Bokkapitel (refereegranskat)abstract
- I kapitlet görs en kort genomgång av viktiga utvecklingssteg under barns skoltid.
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| 5. |
- Schad, Elinor, et al.
(författare)
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Introducing a Swedish Translation of the Workplace Incivility Scale
- 2014
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- This article reports the reliability and validity of the Swedish version of the Workplace Incivility Scale (WIS), a 7-item self-report measure assessing subjectively appraised workplace incivility. The scale was offered to all 490 white-collar employees in a medium size Swedish company resulting in a response frequency of 54 % consisting of 266 participants. The results indicate a good internal consistency with an alpha value of .88 comparable to the original results reported by Cortina, Magley, Williams, and Langhout (2001). The construct validity of the translated scale was demonstrated by a one- factor solution and correlations with theoretically relevant concepts support the convergent validity. The results support the use of the Swedish translation of WIS as a reliable and valid instrument to measure workplace incivility.
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| 6. |
- Schad, Elinor, et al.
(författare)
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Psykologbedömning av barn i skolåldern
- 2014
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Ingår i: Evidensbaserad elevhälsa. - 9789144089690 ; , s. 205-219
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Bokkapitel (refereegranskat)abstract
- Abstract in Undetermined I detta kapitel har vi beskrivit psykologbedömningar på individnivå och satt in dessa i sin kontext. Vi har lyft fram betydelsen av att se eleven i sitt sammanhang – hemma såväl som i skolan – samt betonat vikten av de systemteoretiska faktorer som påverkar skolframgång, exempelvis lärarnas metoder och deras möjlighet att få pedagogiskt stöd. Detta är faktorer som är föränderliga och påverkbara och som har vital och avgörande betydelse för alla barns utbildning, utveckling och hälsa.
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| 7. |
- Schad, Elinor, et al.
(författare)
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Special Education in Sweden
- 2014
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Ingår i: Encyclopedia of special education: A reference for the education of children, adolescents, and adults with disabilities and other exceptional individuals.
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Bokkapitel (refereegranskat)
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| 8. |
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| 9. |
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| 10. |
- Torkelson, Eva, et al.
(författare)
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Factors contributing to the perpetration of workplace incivility: the importance of organizational aspects and experiencing incivility from others
- 2016
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Ingår i: Work & Stress. - : Informa UK Limited. - 0267-8373 .- 1464-5335. ; 30:2, s. 115-131
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Tidskriftsartikel (refereegranskat)abstract
- In recent years a growing amount of research has been conductedin the area of workplace incivility. Whereas many studies havefocused on the victims and the consequences of incivility, littleattention has been paid to the perpetrators and antecedents ofworkplace incivility. This study aims to identify possibleantecedents of workplace incivility, by investigating organizationalaspects as well as the possibility that being the target of incivilityfrom co-workers and supervisors could induce incivility. A total of512 employees (378 women and 133 men) in the school sector ina Swedish municipality completed an online questionnaire.Overall, the results of structural equation modelling analysesshowed that organizational variables were related to theperpetration of incivility. A direct relationship was found betweenbeing uncivil and organizational change, job insecurity, low socialsupport from co-workers and high job demands. However, thestrongest relationship was found between experienced incivilityfrom co-workers and instigated incivility. This could be reflecting aclimate or culture of incivility in the organization, and carryimplications for future practice in interventions against workplaceincivility. The results indicate the importance of focusing on theperspective of the instigator to gain knowledge about the processof workplace incivility.
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| 11. |
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| 12. |
- Wetterling, Friedrich, et al.
(författare)
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Investigating potentially salvageable penumbra tissue in an in vivo model of transient ischemic stroke using sodium, diffusion, and perfusion magnetic resonance imaging
- 2016
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Ingår i: BMC Neuroscience. - : Springer Science and Business Media LLC. - 1471-2202. ; 17:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: Diffusion magnetic resonance imaging (MRI) is the current-state-of-the-art technique to clinically investigate acute (0-24 h) ischemic stroke tissue. However, reduced apparent diffusion coefficient (ADC)-considered a marker of tissue damage-was observed to reverse spontaneously during the subacute stroke phase (24-72 h) which means that low ADC cannot be used to reflect the damaged tissue after 24 h in experimental and clinical studies. One reason for the change in ADC is that ADC values drop with cytotoxic edema (acute phase) and rise when vasogenic edema begins (subacute phase). Recently, combined 1H- and 23Na-MRI was proposed as a more accurate approach to improve delineation between reversible (penumbra) and irreversible ischemic injury (core). The aim of this study was to investigate the effects of reperfusion on the ADC and the sodium MRI signal after experimental ischemic stroke in rats in well-defined areas of different viability levels of the cerebral lesion, i.e. core and penumbra as defined via perfusion and histology. Transient middle cerebral artery occlusion was induced in male rats by using the intraluminal filament technique. MRI sodium, perfusion and diffusion measurement was recorded before reperfusion, shortly after reperfusion and 24 h after reperfusion. The animals were reperfused after 90 min of ischemia. Results: Sodium signal in core did not change before reperfusion, increased after reperfusion while sodium signal in penumbra was significantly reduced before reperfusion, but showed no changes after reperfusion compared to control. The ADC was significantly decreased in core tissue at all three time points compared to contralateral side. This decrease recovered above commonly applied viability thresholds in the core after 24 h. Conclusions: Reduced sodium-MRI signal in conjunction with reduced ADC can serve as a viability marker for penumbra detection and complement hydrogen diffusion- and perfusion-MRI in order to facilitate time-independent assessment of tissue fate and cellular bioenergetics failure in stroke patients.
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