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Sökning: WFRF:(Schröder Sven)

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  • Cuzick, Jack, et al. (författare)
  • Prevention and early detection of prostate cancer.
  • 2014
  • Ingår i: The Lancet Oncology. - 1470-2045 .- 1474-5488. ; 15:11, s. e484-92
  • Tidskriftsartikel (refereegranskat)abstract
    • Prostate cancer is a common malignancy in men and the worldwide burden of this disease is rising. Lifestyle modifications such as smoking cessation, exercise, and weight control offer opportunities to reduce the risk of developing prostate cancer. Early detection of prostate cancer by prostate-specific antigen (PSA) screening is controversial, but changes in the PSA threshold, frequency of screening, and the use of other biomarkers have the potential to minimise the overdiagnosis associated with PSA screening. Several new biomarkers for individuals with raised PSA concentrations or those diagnosed with prostate cancer are likely to identify individuals who can be spared aggressive treatment. Several pharmacological agents such as 5α-reductase inhibitors and aspirin could prevent development of prostate cancer. In this Review, we discuss the present evidence and research questions regarding prevention, early detection of prostate cancer, and management of men either at high risk of prostate cancer or diagnosed with low-grade prostate cancer.
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  • Grüning, Björn, et al. (författare)
  • Bioconda: A sustainable and comprehensive software distribution for the life sciences
  • 2017
  • Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
    • We present Bioconda (https://bioconda.github.io), a distribution of bioinformatics software for the lightweight, multi-platform and language-agnostic package manager Conda. Currently, Bioconda offers a collection of over 3000 software packages, which is continuously maintained, updated, and extended by a growing global community of more than 200 contributors. Bioconda improves analysis reproducibility by allowing users to define isolated environments with defined software versions, all of which are easily installed and managed without administrative privileges.
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  • Tummala, Gopi Krishna, 1986-, et al. (författare)
  • Light scattering in poly (vinyl alcohol) hydrogels reinforced with nanocellulose for ophthalmic use
  • 2017
  • Ingår i: Optical Materials Express. - : Optical Society of America. - 2159-3930 .- 2159-3930. ; 7:8, s. 2824-2837
  • Tidskriftsartikel (refereegranskat)abstract
    • Scattering of ophthalmic devices is a complex phenomenon involving both surface and bulk light-material interactions. In this work, light scattering of nanocellulose reinforced PVA hydrogels contact lenses for ophthalmic applications was investigated. Optical microscopy, fluorescence microscopy and atomic force microscopy (AFM) techniques were used for ultrastructure characterization. Further, 3D angle resolved light scattering measurements in the visible spectral range were performed using a BTDF (bidirectional transmittance distribution function) sensor to quantify the scattered light. Surface and bulk scattering properties were discerned using white light interferometry. Total scatter levels ranging from 3% to 40% were observed depending on the hydrogel composition. The most critical factor affecting the light scattering properties in nanocellulose-reinforced PVA hydrogels was related to the state of hydration of the hydrogels, which is critical to maintain visual acuity of ophthalmic devices.
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