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- Gustafson, Karl P. J., et al.
(författare)
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Chemoenzymatic Dynamic Kinetic Resolution of Primary Benzylic Amines using Pd-0-CalB CLEA as a Biohybrid Catalyst
- 2019
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Ingår i: Chemistry - A European Journal. - : Wiley. - 0947-6539 .- 1521-3765. ; 25:39, s. 9174-9179
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Tidskriftsartikel (refereegranskat)abstract
- Herein, we report on the use a biohybrid catalyst consisting of palladium nanoparticles immobilized on cross-linked enzyme aggregates of lipase B of Candida antarctica (CalB CLEA) for the dynamic kinetic resolution (DKR) of benzylic amines. A set of amines were demonstrated to undergo an efficient DKR and the recyclability of the catalysts was studied. Extensive efforts to further elucidate the structure of the catalyst are presented.
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- Siegel, Corey A., et al.
(författare)
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Development of an index to define overall disease severity in IBD
- 2018
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Ingår i: Gut. - London, United Kingdom : BMJ Publishing Group Ltd. - 0017-5749 .- 1468-3288. ; 67:2, s. 244-254
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Tidskriftsartikel (refereegranskat)abstract
- Background and aim: Disease activity for Crohn's disease (CD) and UC is typically defined based on symptoms at a moment in time, and ignores the long-term burden of disease. The aims of this study were to select the attributes determining overall disease severity, to rank the importance of and to score these individual attributes for both CD and UC.Methods: Using a modified Delphi panel, 14 members of the International Organization for the Study of Inflammatory Bowel Diseases (IOIBD) selected the most important attributes related to IBD. Eighteen IOIBD members then completed a statistical exercise (conjoint analysis) to create a relative ranking of these attributes. Adjusted utilities were developed by creating proportions for each level within an attribute.Results: For CD, 15.8% of overall disease severity was attributed to the presence of mucosal lesions, 10.9% to history of a fistula, 9.7% to history of abscess and 7.4% to history of intestinal resection. For UC, 18.1% of overall disease severity was attributed to mucosal lesions, followed by 14.0% for impact on daily activities, 11.2% C reactive protein and 10.1% for prior experience with biologics. Overall disease severity indices were created on a 100-point scale by applying each attribute's average importance to the adjusted utilities.Conclusions: Based on specialist opinion, overall CD severity was associated more with intestinal damage, in contrast to overall UC disease severity, which was more dependent on symptoms and impact on daily life. Once validated, disease severity indices may provide a useful tool for consistent assessment of overall disease severity in patients with IBD.
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| 4. |
- Tabar, László K., et al.
(författare)
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Three Digital Mammography Display Configurations : Observer Performance in a Pilot ROC Study
- 2010
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Ingår i: Digital Mammography. - Berlin, Germany : Springer-Verlag. - 9783642136658 ; , s. 280-287
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Konferensbidrag (refereegranskat)abstract
- The purpose of this study was to determine if displays that provide more grayscale levels (10bit vs. 8bit) can improve observer performance in breast cancer detection. The study was also designed to determine if 3MP (million-pixel) displays can achieve similar observer performance as compared to 5MP displays. The study was performed using the WorkstationOne mammography software on Dome (R) E5 and E3 high-resolution displays. Ten radiologists reviewed 33 digital mammography screening studies. On 5MP displays, the average Az value across all observers was 0.7912 using 8bit displays, and 0.8306 using 10bit displays. The difference between 8bit and 10bit displays is statistically significant (F=4.43, p=0.0157). The difference of the average Az value from 8bit 3MP displays is not statistically significant compared to reading with 5MP displays. The implications of the study are that, using appropriate software and hardware, 5MP 10bit displays may improve diagnostic accuracy and 3MP displays may not impact negatively diagnostic accuracy.
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| 5. |
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- 2019
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Tidskriftsartikel (refereegranskat)
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