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- Okhuijsen-Pfeifer, C, et al.
(författare)
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Genome-wide association analyses of symptom severity among clozapine-treated patients with schizophrenia spectrum disorders
- 2022
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Ingår i: Translational psychiatry. - : Springer Science and Business Media LLC. - 2158-3188. ; 12:1, s. 145-
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Tidskriftsartikel (refereegranskat)abstract
- Clozapine is the most effective antipsychotic for patients with treatment-resistant schizophrenia. However, response is highly variable and possible genetic underpinnings of this variability remain unknown. Here, we performed polygenic risk score (PRS) analyses to estimate the amount of variance in symptom severity among clozapine-treated patients explained by PRSs (R2) and examined the association between symptom severity and genotype-predicted CYP1A2, CYP2D6, and CYP2C19 enzyme activity. Genome-wide association (GWA) analyses were performed to explore loci associated with symptom severity. A multicenter cohort of 804 patients (after quality control N = 684) with schizophrenia spectrum disorder treated with clozapine were cross-sectionally assessed using the Positive and Negative Syndrome Scale and/or the Clinical Global Impression-Severity (CGI-S) scale. GWA and PRS regression analyses were conducted. Genotype-predicted CYP1A2, CYP2D6, and CYP2C19 enzyme activities were calculated. Schizophrenia-PRS was most significantly and positively associated with low symptom severity (p = 1.03 × 10−3; R2 = 1.85). Cross-disorder-PRS was also positively associated with lower CGI-S score (p = 0.01; R2 = 0.81). Compared to the lowest tertile, patients in the highest schizophrenia-PRS tertile had 1.94 times (p = 6.84×10−4) increased probability of low symptom severity. Higher genotype-predicted CYP2C19 enzyme activity was independently associated with lower symptom severity (p = 8.44×10−3). While no locus surpassed the genome-wide significance threshold, rs1923778 within NFIB showed a suggestive association (p = 3.78×10−7) with symptom severity. We show that high schizophrenia-PRS and genotype-predicted CYP2C19 enzyme activity are independently associated with lower symptom severity among individuals treated with clozapine. Our findings open avenues for future pharmacogenomic projects investigating the potential of PRS and genotype-predicted CYP-activity in schizophrenia.
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| 4. |
- Schreiter, Tim, et al.
(författare)
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Advantages of Multimodal versus Verbal-Only Robot-to-Human Communication with an Anthropomorphic Robotic Mock Driver
- 2023
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Ingår i: 2023 32nd IEEE International Conference on Robot and Human Interactive Communication (RO-MAN). - : IEEE. - 9798350336702 - 9798350336719 ; , s. 293-300
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Konferensbidrag (refereegranskat)abstract
- Robots are increasingly used in shared environments with humans, making effective communication a necessity for successful human-robot interaction. In our work, we study a crucial component: active communication of robot intent. Here, we present an anthropomorphic solution where a humanoid robot communicates the intent of its host robot acting as an “Anthropomorphic Robotic Mock Driver” (ARMoD). We evaluate this approach in two experiments in which participants work alongside a mobile robot on various tasks, while the ARMoD communicates a need for human attention, when required, or gives instructions to collaborate on a joint task. The experiments feature two interaction styles of the ARMoD: a verbal-only mode using only speech and a multimodal mode, additionally including robotic gaze and pointing gestures to support communication and register intent in space. Our results show that the multimodal interaction style, including head movements and eye gaze as well as pointing gestures, leads to more natural fixation behavior. Participants naturally identified and fixated longer on the areas relevant for intent communication, and reacted faster to instructions in collaborative tasks. Our research further indicates that the ARMoD intent communication improves engagement and social interaction with mobile robots in workplace settings.
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| 5. |
- Schreiter, Tim, 1997-, et al.
(författare)
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Advantages of Multimodal versus Verbal-Only Robot-to-Human Communication with an Anthropomorphic Robotic Mock Driver
- 2023
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Ingår i: 2023 32nd IEEE International Conference on Robot and Human Interactive Communication (RO-MAN). - : IEEE. - 9798350336702 - 9798350336719 ; , s. 293-300
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Konferensbidrag (refereegranskat)abstract
- Robots are increasingly used in shared environments with humans, making effective communication a necessity for successful human-robot interaction. In our work, we study a crucial component: active communication of robot intent. Here, we present an anthropomorphic solution where a humanoid robot communicates the intent of its host robot acting as an "Anthropomorphic Robotic Mock Driver" (ARMoD). We evaluate this approach in two experiments in which participants work alongside a mobile robot on various tasks, while the ARMoD communicates a need for human attention, when required, or gives instructions to collaborate on a joint task. The experiments feature two interaction styles of the ARMoD: a verbal-only mode using only speech and a multimodal mode, additionally including robotic gaze and pointing gestures to support communication and register intent in space. Our results show that the multimodal interaction style, including head movements and eye gaze as well as pointing gestures, leads to more natural fixation behavior. Participants naturally identified and fixated longer on the areas relevant for intent communication, and reacted faster to instructions in collaborative tasks. Our research further indicates that the ARMoD intent communication improves engagement and social interaction with mobile robots in workplace settings.
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