| 1. |
- Chumak, A. V., et al.
(författare)
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Advances in Magnetics Roadmap on Spin-Wave Computing
- 2022
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Ingår i: IEEE Transactions on Magnetics. - 0018-9464. ; 58:6
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Tidskriftsartikel (refereegranskat)abstract
- Magnonics addresses the physical properties of spin waves and utilizes them for data processing. Scalability down to atomic dimensions, operation in the GHz-to-THz frequency range, utilization of nonlinear and nonreciprocal phenomena, and compatibility with CMOS are just a few of many advantages offered by magnons. Although magnonics is still primarily positioned in the academic domain, the scientific and technological challenges of the field are being extensively investigated, and many proof-of-concept prototypes have already been realized in laboratories. This roadmap is a product of the collective work of many authors that covers versatile spin-wave computing approaches, conceptual building blocks, and underlying physical phenomena. In particular, the roadmap discusses the computation operations with Boolean digital data, unconventional approaches like neuromorphic computing, and the progress towards magnon-based quantum computing. The article is organized as a collection of sub-sections grouped into seven large thematic sections. Each sub-section is prepared by one or a group of authors and concludes with a brief description of current challenges and the outlook of further development for each research direction. Author
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| 2. |
- Schultheiss, K., et al.
(författare)
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Excitation of Whispering Gallery Magnons in a Magnetic Vortex
- 2019
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 122
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Tidskriftsartikel (refereegranskat)abstract
- We present the generation of whispering gallery magnons with unprecedented high wave vectors via nonlinear 3-magnon scattering in a μm-sized magnetic Ni81Fe19 disc which is in the vortex state. These modes exhibit a strong localization at the perimeter of the disc and practically zero amplitude in an extended area around the vortex core. They originate from the splitting of the fundamental radial magnon modes, which can be resonantly excited in a vortex texture by an out-of-plane microwave field. We shed light on the basics of this nonlinear scattering mechanism from an experimental and theoretical point of view. Using Brillouin light scattering microscopy, we investigated the frequency and power dependence of the 3-magnon splitting. The spatially resolved mode profiles give evidence for the localization at the boundaries of the disc and allow for a direct determination of the modes wave number.
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| 3. |
- Aswad, Amr, et al.
(författare)
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Evolutionary history of endogenous Human Herpesvirus 6 reflects human migration out of Africa
- 2021
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Ingår i: Molecular biology and evolution. - : Oxford University Press. - 0737-4038 .- 1537-1719. ; 38:1, s. 96-107
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Tidskriftsartikel (refereegranskat)abstract
- Human herpesvirus 6A and 6B (HHV-6) can integrate into the germline, and as a result about 70 million people harbour the genome of one of these viruses in every cell of their body. Until now, it has been largely unknown if i) these integrations are ancient, ii) if they still occur, and iii) whether circulating virus strains differ from integrated ones. Here we used next generation sequencing and mining of public human genome datasets to generate the largest and most diverse collection of circulating and integrated HHV-6 genomes studied to date. In genomes of geographically dispersed, only distantly-related people, we identified clades of integrated viruses that originated from a single ancestral event, confirming this with fluorescent in situ hybridization to directly observe the integration locus. In contrast to HHV-6B, circulating and integrated HHV-6A sequences form distinct clades, arguing against ongoing integration of circulating HHV-6A or "reactivation" of integrated HHV-6A. Taken together, our study provides the first comprehensive picture of the evolution of HHV-6, and reveals that integration of heritable HHV-6 has occurred since the time of, if not before, human migrations out of Africa.
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| 4. |
- Fallqvist, Mikael, et al.
(författare)
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Influence of CVD Al2O3 coated tool surface micro topography on the tribological characteristics in metal cutting : part I
- 2013
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Ingår i: Wear. - : Elsevier. - 0043-1648 .- 1873-2577. ; , s. 87-98
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Tidskriftsartikel (refereegranskat)abstract
- The influence of surface micro topography of CVD α-Al2O3 coatings, deposited on cemented carbide inserts, on tribological characteristics in sliding contact and in metal cutting has been investigated using quenched and tempered steel as counter/work material. Pin-on-disc and turning tests were carried out and post-test characterization using 3D optical surface profilometry and scanning electron microscopy was performed in order to investigate the tribological response of the coatings. The results show that surface micro topography can have a significant impact on the tribological performance of Al2O3 coatings under initial and cutting contact conditions. For both kinds of tests the tendency for transfer of workpiece material strongly increases with increasing coating micro topography. In the pin-on-disc tests, a smooth coating surface significantly reduces the friction coefficient. In the turning tests the contact conditions at the flank face increase with decreasing micro topography. In contrast, no general conclusions can be drawn regarding the influence of coating micro topography on the contact conditions at the rake face. The resulting topography of the turned surface was found to increase with increasing coating topography.
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| 5. |
- Johansson, J., et al.
(författare)
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Determining process parameters for successful material reclamation of lead-free brass chips using hot forging operations: Lubrication
- 2019
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Ingår i: 26th CIRP Conference on Life Cycle Engineering (LCE) Purdue University, West Lafayette, IN, USA May 7-9, 2019. - : Elsevier BV. - 2212-8271. ; 80, s. 108-113
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Konferensbidrag (refereegranskat)abstract
- When small and hollow components are being manufactured, it is not uncommon that a majority of the workpiece material is removed by machining. A demand for parts made with lead-free brass alloys can potentially increase the manufacturing cost and therefore it is necessary to investigate ways to increase the material utilization. As part of a more resource efficient production, a method for reusing chips from metal cutting in brass using hot forging operations is investigated. In this study, the brass alloy CW724R is used. Different lubrication agents are used, including mineral oil and vegetable oil with and without addition of nano-sized graphite platelets, GnP, in the production of green compacts. Material properties of the green compacts and the finished products are analyzed using mechanical testing and microscopy. Quality of the finished product is evaluated using multi-variable regression analysis. The results of the statistical analysis indicate the best mechanical properties when using 0.2 - 0.25 vol. % GnP suspension in oil and 0.15 - 0.2 wt. % oil mixed with the chips before compaction. Microscopy shows diffusion bonding between the chips after forging, yet some porosities is still observed. This indicates potential for the investigated material reclamation method.
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| 6. |
- Johansson, J., et al.
(författare)
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Machinability evaluation of low-lead brass alloys
- 2020
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Ingår i: Procedia Manufacturing. - : Elsevier BV. - 2351-9789. ; 38, s. 1723-1730
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Tidskriftsartikel (refereegranskat)abstract
- The machinability of brass is considered to increase with the addition of lead as an alloying element. Due to both environmental and health reasons, the decrease of lead in brass components is of high importance. Several mechanical and thermal material properties control a materials machinability, in combination with the chosen machining system. To evaluate the difference in machinability between a traditional free-machining leaded alloy and brass alloys with low lead content, material properties influencing the machinability have been measured. Results of machining, such as burr formation and difference in cutting forces and cutting resistance has been studied. The presented results indicates that alloys with lower lead content do not show as good machinability as leaded brass. However, investigations show that the machinability for some of the alloys with low lead content is not considerably worse compared to alloys with a high lead content, making them viable options for a more sustainable production.
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| 7. |
- Oghazi, Pejvak, 1979-, et al.
(författare)
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User self-disclosure on social network sites : A cross-cultural study on Facebook's privacy concepts
- 2020
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Ingår i: Journal of Business Research. - New York : Elsevier. - 0148-2963 .- 1873-7978. ; 112, s. 531-540
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Tidskriftsartikel (refereegranskat)abstract
- This study investigates a cross-cultural comparison between Germany and Norway regarding users' self-disclosure of personal information on social network sites (SNSs). More specifically, the study considers three antecedents of privacy, namely concerns, attitudes, and intentions, and evaluates their potential effects on self-disclosure, considering Facebook as the SNS of choice. The study employs a deductive research approach and develops a conceptual model based on the theoretical analysis. Data is collected via an online survey of users in Germany and Norway. The results show that privacy intention is the only antecedent that has a significant direct influence on users' self-disclosure of information. By contrast, neither privacy concerns nor privacy attitude have a statistically significant influence on self-disclosure. Additionally, there are statistically significant differences between the German and Norwegian samples in privacy concepts and reported self-disclosure. The results support the creation of more transparent privacy policies by SNS providers to improve targeted marketing.
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| 8. |
- Schlosser, Pascal, et al.
(författare)
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Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine
- 2023
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Ingår i: Nature Genetics. - 1546-1718. ; 55:6, s. 995-1008
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Tidskriftsartikel (refereegranskat)abstract
- The kidneys operate at the interface of plasma and urine by clearing molecular waste products while retaining valuable solutes. Genetic studies of paired plasma and urine metabolomes may identify underlying processes. We conducted genome-wide studies of 1,916 plasma and urine metabolites and detected 1,299 significant associations. Associations with 40% of implicated metabolites would have been missed by studying plasma alone. We detected urine-specific findings that provide information about metabolite reabsorption in the kidney, such as aquaporin (AQP)-7-mediated glycerol transport, and different metabolomic footprints of kidney-expressed proteins in plasma and urine that are consistent with their localization and function, including the transporters NaDC3 (SLC13A3) and ASBT (SLC10A2). Shared genetic determinants of 7,073 metabolite-disease combinations represent a resource to better understand metabolic diseases and revealed connections of dipeptidase 1 with circulating digestive enzymes and with hypertension. Extending genetic studies of the metabolome beyond plasma yields unique insights into processes at the interface of body compartments.
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| 9. |
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| 10. |
- Schultheiss, F, et al.
(författare)
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Influence of CVD Al2O3 coated tool surface micro topography on the tribological characteristics in metal cutting : part II
- 2013
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Ingår i: Wear. - : Elsevier. - 0043-1648 .- 1873-2577. ; 298, s. 23-31
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Tidskriftsartikel (refereegranskat)abstract
- The tribological conditions at the contact between the cutting tool and the chip are of great importance when analyzing the machining process. By knowing the contact conditions on the rake face of the cutting tool the wear on the clearance and rake face may be predicted in terms of size and type of wear. A certain value of the surface stresses is often thought of as leading to a higher wear rate of the cutting tool and thus a shorter tool life. In this article two different methods for experimentally measuring the contact condition on the clearance and rake face of the cutting tool are presented and illustrated with results obtained while turning AISI 4140. Results are also obtained in terms of how the surface roughness value of the cutting tool influences the contact condition. It was found that the tool surface topography may have a significant impact on the tribological performance during machining.
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| 11. |
- Schultheiss, U. T., et al.
(författare)
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Thyroid function, renal events and mortality in chronic kidney disease patients: the German Chronic Kidney Disease study
- 2021
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Ingår i: Clinical Kidney Journal. - : Oxford University Press (OUP). - 2048-8505 .- 2048-8513. ; 14:3, s. 959-968
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Tidskriftsartikel (refereegranskat)abstract
- Background. Hypothyroidism and low free triiodothyronine (FT3) syndrome [low FT3 levels with normal thyroid-stimulating hormone (TSH)] have been associated with reduced kidney function cross-sectionally in chronic kidney disease (CKD) patients with severely reduced estimated glomerular filtration rate (eGFR) or end-stage kidney disease (ESKD). Results on the prospective effects of impaired thyroid function on renal events and mortality for patients with severely reduced eGFR or from population-based cohorts are conflicting. Here we evaluated the association between thyroid and kidney function with eGFR (cross-sectionally) as well as renal events and mortality (prospectively) in a large, prospective cohort of CKD patients with mild to moderately reduced kidney function. Methods. Thyroid markers were measured among CKD patients from the German Chronic Kidney Disease study. Incident renal endpoints (combined ESKD, acute kidney injury and renal death) and all-cause mortality were abstracted from hospital records and death certificates. Time to first event analysis of complete data from baseline to the 4-year follow-up (median follow-up time 4.04years) of 4600 patients was conducted. Multivariable linear regression and Cox proportional hazards models were fitted for single and combined continuous thyroid markers [TSH, free thyroxine (FT4), FT3] and thyroid status. Results. Cross-sectionally, the presence of low-FT3 syndrome showed a significant inverse association with eGFR and continuous FT3 levels alone showed a significant positive association with eGFR; in combination with FT4 and TSH, FT3 levels also showed a positive association and FT4 levels showed a negative association with eGFR. Prospectively, higher FT4 and lower FT3 levels were significantly associated with a higher risk of all-cause mortality (N-events=297). Per picomole per litre higher FT3 levels the risk of reaching the composite renal endpoint was 0.73-fold lower (95% confidence interval 0.65-0.82; N-events=615). Compared with euthyroid patients, patients with low-FT3 syndrome had a 2.2-fold higher risk and patients with hypothyroidism had a 1.6-fold higher risk of experiencing the composite renal endpoint. Conclusions. Patients with mild to moderate CKD suffering from thyroid function abnormalities are at an increased risk of adverse renal events and all-cause mortality over time.
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| 12. |
- Windmark, Christina, et al.
(författare)
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Batch size optimization based on production part cost
- 2014
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Ingår i: FAIM 2014 - Proceedings of the 24th International Conference on Flexible Automation and Intelligent Manufacturing: Capturing Competitive Advantage via Advanced Manufacturing and Enterprise Transformation. - 9781605951737 ; , s. 1031-1038
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Konferensbidrag (refereegranskat)abstract
- When investigating different location and/or system designs the possible variables to take into consideration can differs between the alternatives. Different production system will have different optimal working conditions and hence should be compared with parameters suitable for the actual production system. When planning production and calculating production costs the batch size is of high interest. Based on a manufacturing part cost model, this paper will present a new model, close connected to the production system, integrating production performance, set-up times, material costs, material handling costs and tied capital, giving the production economic optimal batch size. The aim is to give companies a model for determining the economic optimal batch size in order to use this knowledge to make strategic decisions regarding production planning. Mathematical simulations are performed to analyse the differences in result from the developed model and Wilsons existing standard method for calculating the economic order quantity, hence to verify the importance of making an in-depth analysis, taking the production system into consideration. The advantage of the developed model is the usage of production costs based on variable batch sizes, giving a more accurate outcome.
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| 13. |
- Winitzki, D., et al.
(författare)
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Educational Attainment Is Associated With Kidney and Cardiovascular Outcomes in the German CKD (GCKD) Cohort
- 2022
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Ingår i: Kidney International Reports. - : Elsevier BV. - 2468-0249. ; 7:5, s. 1004-1015
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: Prospective data on impact of educational attainment on prognosis in patients with chronic kidney disease (CKD) are scarce. We investigated the association between educational attainment and all-cause mortality, major adverse cardiovascular (CV) events (MACEs), kidney failure requiring dialysis, and CKD etiology. Methods: Participants (N = 5095, aged 18–74 years) of the ongoing multicenter German Chronic Kidney Disease (GCKD) cohort, enrolled on the basis of an estimated glomerular filtration rate (eGFR) of 30 to 60 ml/min (stages G3, A1–A3) or overt proteinuria (stages G1–G2, A3), were divided into 3 categories according to their educational attainment and were followed for 6.5 years. Results: Participants with low educational attainment (vs. high) had a higher risk for mortality (hazard ratio [HR] 1.48, 95% CI: 1.16–1.90), MACE (HR 1.37, 95% CI: 1.02–1.83), and kidney failure (HR 1.54, 95% CI: 1.15–2.05). Mediators between low educational attainment and mortality were smoking, CV disease (CVD) at baseline, low income, higher body mass index, and higher serum levels of CRP, high-density lipoprotein cholesterol, uric acid, NGAL, BAP, NT-proBNP, OPN, H-FABP, and urea. Low educational attainment was positively associated with diabetic nephropathy (odds ratio [OR] 1.65, 95% CI: 1.36–2.0) and CKD subsequent to acute kidney injury (OR 1.56, 95% CI: 1.03–2.35), but negatively associated with IgA nephropathy (OR 0.68, 95% CI: 0.52–0.90). Conclusion: Low educational attainment is associated with adverse outcomes and CKD etiology. Lifestyle habits and biomarkers mediate associations between low educational attainment and mortality. Recognition of the role of educational attainment and the associated health-relevant risk factors is important to optimize the care of patients with CKD and improve prognosis. © 2022 International Society of Nephrology
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| 14. |
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