| 1. |
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| 2. |
- Ruilope, LM, et al.
(författare)
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Design and Baseline Characteristics of the Finerenone in Reducing Cardiovascular Mortality and Morbidity in Diabetic Kidney Disease Trial
- 2019
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Ingår i: American journal of nephrology. - : S. Karger AG. - 1421-9670 .- 0250-8095. ; 50:5, s. 345-356
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Tidskriftsartikel (refereegranskat)abstract
- <b><i>Background:</i></b> Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. <b><i>Patients and</i></b> <b><i>Methods:</i></b> The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate ≥25 mL/min/1.73 m<sup>2</sup> and albuminuria (urinary albumin-to-creatinine ratio ≥30 to ≤5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level α = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. <b><i>Conclusions:</i></b> FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049.
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| 3. |
- Tran, K. B., et al.
(författare)
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The global burden of cancer attributable to risk factors, 2010-19: a systematic analysis for the Global Burden of Disease Study 2019
- 2022
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Ingår i: Lancet. - 0140-6736. ; 400:10352, s. 563-591
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Tidskriftsartikel (refereegranskat)abstract
- Background Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. Methods The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk-outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. Findings Globally, in 2019, the risk factors included in this analysis accounted for 4.45 million (95% uncertainty interval 4.01-4.94) deaths and 105 million (95.0-116) DALYs for both sexes combined, representing 44.4% (41.3-48.4) of all cancer deaths and 42.0% (39.1-45.6) of all DALYs. There were 2.88 million (2.60-3.18) risk-attributable cancer deaths in males (50.6% [47.8-54.1] of all male cancer deaths) and 1.58 million (1.36-1.84) risk-attributable cancer deaths in females (36.3% [32.5-41.3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20.4% (12.6-28.4) and DALYs by 16.8% (8.8-25.0), with the greatest percentage increase in metabolic risks (34.7% [27.9-42.8] and 33.3% [25.8-42.0]). Interpretation The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden. Copyright (C) 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.
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| 4. |
- Frostad, J. J., et al.
(författare)
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Mapping development and health effects of cooking with solid fuels in low-income and middle-income countries, 2000-18: a geospatial modelling study
- 2022
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Ingår i: Lancet Global Health. - 2214-109X. ; 10:10
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Tidskriftsartikel (refereegranskat)abstract
- Background More than 3 billion people do not have access to clean energy and primarily use solid fuels to cook. Use of solid fuels generates household air pollution, which was associated with more than 2 million deaths in 2019. Although local patterns in cooking vary systematically, subnational trends in use of solid fuels have yet to be comprehensively analysed. We estimated the prevalence of solid-fuel use with high spatial resolution to explore subnational inequalities, assess local progress, and assess the effects on health in low-income and middle-income countries (LMICs) without universal access to clean fuels. Methods We did a geospatial modelling study to map the prevalence of solid-fuel use for cooking at a 5 km x 5 km resolution in 98 LMICs based on 2.1 million household observations of the primary cooking fuel used from 663 population-based household surveys over the years 2000 to 2018. We use observed temporal patterns to forecast household air pollution in 2030 and to assess the probability of attaining the Sustainable Development Goal (SDG) target indicator for clean cooking. We aligned our estimates of household air pollution to geospatial estimates of ambient air pollution to establish the risk transition occurring in LMICs. Finally, we quantified the effect of residual primary solid-fuel use for cooking on child health by doing a counterfactual risk assessment to estimate the proportion of deaths from lower respiratory tract infections in children younger than 5 years that could be associated with household air pollution. Findings Although primary reliance on solid-fuel use for cooking has declined globally, it remains widespread. 593 million people live in districts where the prevalence of solid-fuel use for cooking exceeds 95%. 66% of people in LMICs live in districts that are not on track to meet the SDG target for universal access to clean energy by 2030. Household air pollution continues to be a major contributor to particulate exposure in LMICs, and rising ambient air pollution is undermining potential gains from reductions in the prevalence of solid-fuel use for cooking in many countries. We estimated that, in 2018, 205000 (95% uncertainty interval 147000-257000) children younger than 5 years died from lower respiratory tract infections that could be attributed to household air pollution. Interpretation Efforts to accelerate the adoption of clean cooking fuels need to be substantially increased and recalibrated to account for subnational inequalities, because there are substantial opportunities to improve air quality and avert child mortality associated with household air pollution. Copyright (C) 2022 The Author(s). Published by Elsevier Ltd.
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| 5. |
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| 6. |
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| 7. |
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| 8. |
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| 9. |
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- 2019
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Tidskriftsartikel (refereegranskat)
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| 10. |
- Kanoni, Stavroula, et al.
(författare)
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Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.
- 2022
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Ingår i: Genome biology. - : Springer Science and Business Media LLC. - 1474-760X .- 1465-6906 .- 1474-7596. ; 23:1
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Tidskriftsartikel (refereegranskat)abstract
- Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery.To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N=1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3-5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism.Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk.
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| 11. |
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| 12. |
- Auffray, Charles, et al.
(författare)
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Making sense of big data in health research: Towards an EU action plan
- 2016
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Ingår i: Genome Medicine. - : BIOMED CENTRAL LTD. - 1756-994X. ; 8:71
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Tidskriftsartikel (refereegranskat)abstract
- Medicine and healthcare are undergoing profound changes. Whole-genome sequencing and high-resolution imaging technologies are key drivers of this rapid and crucial transformation. Technological innovation combined with automation and miniaturization has triggered an explosion in data production that will soon reach exabyte proportions. How are we going to deal with this exponential increase in data production? The potential of "big data" for improving health is enormous but, at the same time, we face a wide range of challenges to overcome urgently. Europe is very proud of its cultural diversity; however, exploitation of the data made available through advances in genomic medicine, imaging, and a wide range of mobile health applications or connected devices is hampered by numerous historical, technical, legal, and political barriers. European health systems and databases are diverse and fragmented. There is a lack of harmonization of data formats, processing, analysis, and data transfer, which leads to incompatibilities and lost opportunities. Legal frameworks for data sharing are evolving. Clinicians, researchers, and citizens need improved methods, tools, and training to generate, analyze, and query data effectively. Addressing these barriers will contribute to creating the European Single Market for health, which will improve health arid healthcare for all Europearis.
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| 13. |
- Abbas, Syed Adeel, et al.
(författare)
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Spinel-type Na2MoO4 and Na2WO4 as promising optoelectronic materials : First-principle DFT calculations
- 2020
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Ingår i: Chemical Physics. - : Elsevier. - 0301-0104 .- 1873-4421. ; 538
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Tidskriftsartikel (refereegranskat)abstract
- The mechanical, thermodynamic, electronic, and optical properties of Na2MoO4 (NMO) and Na2WO4 (NWO) spinels are elaborated by density functional theory (DFT) based full potential augmented plane wave method (FP-LAPW + lo). Our optimized lattice constants for the studied spinels are in good agreement with that obtained experimentally. The enthalpy of formation ensures the thermodynamic stability of NMO and NWO in the cubic phase. The Born mechanical stability criteria guarantees their mechanical stability, while Poisson ratio (ν) and Pugh's ratio (B/G) infer their brittle behavior. The Debye temperature (θD) is significant for NMO than NWO. The wide bandgap of 3.5 eV for NMO and 4.4 eV for NWO show the maximum absorption in the ultraviolet region that increases their importance for optoelectronic applications. The optical properties are explained in term of dielectric constant, refractive index, absorption of light, reflection, and optical loss factor.
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| 14. |
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| 16. |
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| 17. |
- Arshad, Nasima, et al.
(författare)
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Synthesis, X-ray, Hirshfeld surface analysis, exploration of DNA binding, urease enzyme inhibition and anticancer activities of novel adamantane-naphthyl thiourea conjugate
- 2021
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Ingår i: Bioorganic chemistry (Print). - : Elsevier. - 0045-2068. ; 109
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Tidskriftsartikel (refereegranskat)abstract
- 1-(adamantane-1-carbonyl-3-(1-naphthyl)) thiourea (C22H24N2OS (4), was synthesized by the reaction of freshly prepared adamantane-1-carbonyl chloride from corresponding acid (3) with ammonium thiocyanate in 1:1 M ratio in dry acetone to afford the adamantane-1-carbonyl isothiocyanate (2) in situ followed by treatment with 1-naphthyl amine (3). The structure was established by elemental analyses, FTIR, H-1, C-13 NMR and mass spectroscopy. The molecular and crystal structure were determined by single crystal X-ray analysis. It belongs to triclinic system P - 1 space group with a = 6.7832(5) angstrom, b = 11.1810(8) angstrom, c = 13.6660(10) angstrom, alpha = 105.941(6)degrees, beta = 103.730(6)degrees, gamma = 104.562(6)degrees, Z = 2, V = 910.82(11) angstrom(3). The naphthyl group is almost planar. In the crystal structure, intermolecular C-H center dot center dot center dot O hydrogen bonds link the molecules into centrosymmetric dimers, enclosing R-2(2)(14) ring motifs, while the intramolecular N-H center dot center dot center dot O hydrogen bonds enclose S(6) ring motifs, in which they may be effective in the stabilization of the structure. The Hirshfeld surface analysis of the crystal structure indicates that the most important contributions for the crystal packing are from H center dot center dot center dot H (59.3%), H center dot center dot center dot C/C center dot center dot center dot H (19.8%) and H center dot center dot center dot S/S center dot center dot center dot H (10.1%) interactions. Hydrogen bonding and van der Waals interactions are the dominant interactions in the crystal packing. DFT, molecular docking and urease inhibition studies revealed stability and electron withdrawing nature of 4 as compared to DNA base pairs and residues of urease. The DNA binding results from docking, UV-visible spectroscopy, and viscosity studies indicated significant binding of 4 with the DNA via intercalation and groove binding. Further investigation of the compound was done on hepatocellular carcinoma; Huh-7 cell line as well as normal human embryonic kidney; Hek-293 cell line. The compound showed significant cytotoxic activity against Huh-7 cells in comparison to normal Hek-293 cells indicating selective cytotoxicity towards cancer cells.
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| 18. |
- Carow, Berit, et al.
(författare)
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Immune mapping of human tuberculosis and sarcoidosis lung granulomas
- 2024
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Ingår i: FRONTIERS IN IMMUNOLOGY. - 1664-3224. ; 14
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Tidskriftsartikel (refereegranskat)abstract
- Tuberculosis (TB) and sarcoidosis are both granulomatous diseases. Here, we compared the immunological microenvironments of granulomas from TB and sarcoidosis patients using in situ sequencing (ISS) transcriptomic analysis and multiplexed immunolabeling of tissue sections. TB lesions consisted of large necrotic and cellular granulomas, whereas "multifocal" granulomas with macrophages or epitheloid cell core and a T-cell rim were observed in sarcoidosis samples. The necrotic core in TB lesions was surrounded by macrophages and encircled by a dense T-cell layer. Within the T-cell layer, compact B-cell aggregates were observed in most TB samples. These B-cell clusters were vascularized and could contain defined B-/T-cell and macrophage-rich areas. The ISS of 40-60 immune transcripts revealed the enriched expression of transcripts involved in homing or migration to lymph nodes, which formed networks at single-cell distances in lymphoid areas of the TB lesions. Instead, myeloid-annotated regions were enriched in CD68, CD14, ITGAM, ITGAX, and CD4 mRNA. CXCL8 and IL1B mRNA were observed in granulocytic areas in which M. tuberculosis was also detected. In line with ISS data indicating tertiary lymphoid structures, immune labeling of TB sections expressed markers of high endothelial venules, follicular dendritic cells, follicular helper T cells, and lymph-node homing receptors on T cells. Neither ISS nor immunolabeling showed evidence of tertiary lymphoid aggregates in sarcoidosis samples. Together, our finding suggests that despite their heterogeneity, the formation of tertiary immune structures is a common feature in granulomas from TB patients.
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| 19. |
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| 20. |
- Khan, Yusra Habib, et al.
(författare)
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Barriers and facilitators of childhood COVID-19 vaccination among parents : A systematic review
- 2022
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Ingår i: Frontiers in Pediatrics. - : Frontiers Media S.A.. - 2296-2360. ; 10
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Forskningsöversikt (refereegranskat)abstract
- BackgroundThe acceptance of vaccination against COVID-19 among parents of young children plays a significant role in controlling the current pandemic. A wide range of factors that influence vaccine hesitancy in adults has been reported worldwide, but less attention has been given to COVID-19 vaccination among children. Vaccine hesitancy is considered a major challenge in achieving herd immunity, and it is more challenging among parents as they remain deeply concerned about their child's health. In this context, a systematic review of the current literature is inevitable to assess vaccine hesitancy among parents of young children to ensure a successful ongoing vaccination program.MethodA systematic search of peer-reviewed English literature indexed in Google Scholar, PubMed, Embase, and Web of science was performed using developed keywords between 1 January 2020 and August 2022. This systematic review included only those studies that focused on parental concerns about COVID-19 vaccines in children up to 12 years without a diagnosis of COVID-19. Following PRISMA guidelines, a total of 108 studies were included. The quality appraisal of the study was performed by Newcastle-Ottawa Scale (NOS).ResultsThe results of 108 studies depict that vaccine hesitancy rates differed globally with a considerably large number of factors associated with it. The highest vaccine hesitancy rates among parents were reported in a study from the USA (86.1%) and two studies from Saudi Arabia (> 85%) and Turkey (89.6%). Conversely, the lowest vaccine hesitancy rates ranging from 0.69 and 2% were found in two studies from South Africa and Switzerland, respectively. The largest study (n = 227,740) was conducted in Switzerland while the smallest sample size (n = 12) was represented by a study conducted in the USA. The most commonly reported barriers to childhood vaccination were mothers' lower education level (N = 46/108, 43%), followed by financial instability (N = 19/108, 18%), low confidence in new vaccines (N = 13/108, 12%), and unmonitored social media platforms (N = 5/108, 4.6%). These factors were significantly associated with vaccine refusal among parents. However, the potential facilitators for vaccine uptake among respondents who intended to have their children vaccinated include higher education level (N = 12/108, 11%), followed by information obtained through healthcare professionals (N = 9/108, 8.3%) and strong confidence in preventive measures taken by the government (N = 5/81, 4.6%).ConclusionThis review underscores that parents around the globe are hesitant to vaccinate their kids against COVID-19. The spectrum of factors associated with vaccine hesitancy and uptake varies across the globe. There is a dire need to address vaccine hesitancy concerns regarding the efficacy and safety of approved vaccines. Local context is inevitable to take into account while developing programs to reduce vaccine hesitancy. There is a dire need to devise strategies to address vaccine hesitancy among parents through the identification of attributing factors.
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| 21. |
- Korkovelos, Alexandros, et al.
(författare)
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A geospatial assessment of small-scale hydropower potential in sub-saharan Africa
- 2018
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Ingår i: Energies. - : MDPI AG. - 1996-1073. ; 11:11
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Tidskriftsartikel (refereegranskat)abstract
- Sub-Saharan Africa has been at the epicenter of an ongoing global dialogue around the issue of energy poverty. More than half of the world's population without access to modern energy services lives there. It also happens to be a sub-continent with plentiful renewable energy resource potential. Hydropower is one of them, and to a large extent it remains untapped. This study focuses on the technical assessment of small-scale hydropower (0.01-10 MW) in Sub-Saharan Africa. The underlying methodology was based on open source geospatial datasets, whose combination allowed a consistent evaluation of 712,615 km of river network spanning over 44 countries. Environmental, topological, and social constraints were included in the form of constraints in the optimization algorithm. The results are presented on a country and power pool basis.
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| 22. |
- Maroufpoor, Saman, et al.
(författare)
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A novel hybridized neuro-fuzzy model with an optimal input combination for dissolved oxygen estimation
- 2022
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Ingår i: Frontiers in Environmental Science. - : Frontiers Media S.A.. - 2296-665X. ; 10
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Tidskriftsartikel (refereegranskat)abstract
- Dissolved oxygen (DO) is one of the main prerequisites to protect amphibian biological systems and to support powerful administration choices. This research investigated the applicability of Shannon’s entropy theory and correlation in obtaining the combination of the optimum inputs, and then the abstracted input variables were used to develop three novel intelligent hybrid models, namely, NF-GWO (neuro-fuzzy with grey wolf optimizer), NF-SC (subtractive clustering), and NF-FCM (fuzzy c-mean), for estimation of DO concentration. Seven different input combinations of water quality variables, including water temperature (TE), specific conductivity (SC), turbidity (Tu), and pH, were used to develop the prediction models at two stations in California. The performance of proposed models for DO estimation was assessed using statistical metrics and visual interpretation. The results revealed the better performance of NF-GWO for all input combinations than other models where its performance was improved by 24.2–66.2% and 14.9–31.2% in terms of CC (correlation coefficient) and WI (Willmott index) compared to standalone NF for different input combinations. Additionally, the MAE (mean absolute error) and RMSE (root mean absolute error) of the NF model were reduced using the NF-GWO model by 9.9–46.0% and 8.9–47.5%, respectively. Therefore, NF-GWO with all water quality variables as input can be considered the optimal model for predicting DO concentration of the two stations. In contrast, NF-SC performed worst for most of the input combinations. The violin plot of NF-GWO-predicted DO was found most similar to the violin plot of observed data. The dissimilarity with the observed violin was found high for the NF-FCM model. Therefore, this study promotes the hybrid intelligence models to predict DO concentration accurately and resolve complex hydro-environmental problems.
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| 23. |
- Masood, KI, et al.
(författare)
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Upregulated type I interferon responses in asymptomatic COVID-19 infection are associated with improved clinical outcome
- 2021
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Ingår i: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 11:1, s. 22958-
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Tidskriftsartikel (refereegranskat)abstract
- Understanding key host protective mechanisms against SARS-CoV-2 infection can help improve treatment modalities for COVID-19. We used a blood transcriptome approach to study biomarkers associated with differing severity of COVID-19, comparing severe and mild Symptomatic disease with Asymptomatic COVID-19 and uninfected Controls. There was suppression of antigen presentation but upregulation of inflammatory and viral mRNA translation associated pathways in Symptomatic as compared with Asymptomatic cases. In severe COVID-19, CD177 a neutrophil marker, was upregulated while interferon stimulated genes (ISGs) were downregulated. Asymptomatic COVID-19 cases displayed upregulation of ISGs and humoral response genes with downregulation of ICAM3 and TLR8. Compared across the COVID-19 disease spectrum, we found type I interferon (IFN) responses to be significantly upregulated (IFNAR2, IRF2BP1, IRF4, MAVS, SAMHD1, TRIM1), or downregulated (SOCS3, IRF2BP2, IRF2BPL) in Asymptomatic as compared with mild and severe COVID-19, with the dysregulation of an increasing number of ISGs associated with progressive disease. These data suggest that initial early responses against SARS-CoV-2 may be effectively controlled by ISGs. Therefore, we hypothesize that treatment with type I interferons in the early stage of COVID-19 may limit disease progression by limiting SARS-CoV-2 in the host.
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| 24. |
- Mentis, Dimitris, et al.
(författare)
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Assessing the technical wind energy potential in Africa a GIS-based approach
- 2015
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Ingår i: Renewable energy. - : Elsevier BV. - 0960-1481 .- 1879-0682. ; 83, s. 110-125
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Tidskriftsartikel (refereegranskat)abstract
- Nowadays, Africa faces the challenge of generating more electricity to meet existing and future demand in a sustainable way. Africa is a privileged continent in terms of wind resource regime. However, very little of this has been utilized. It is thus essential to identify and define the amount of wind energy that could be technically exploited on the continent. The utilization of wind energy is associated with a myriad of localization criteria and thus it should be systematically addressed by spatial assessments to guarantee its harmonization with socio-economic systems, infrastructure and ecosystems. This study focuses on onshore wind power on the African continent and strives to provide estimates of theoretical, geographical and technical potential based on state of the art wind power technology. Maps of wind power potential at 80m, which is the hub height of a modern wind turbine will be derived via statistical distribution of wind speed data and implementation of wind power curves. Screening criteria regarding the localization of wind farms and related to socio-economic and geographic constraints are outlined and implemented through a thorough GIS analysis. The results of this work are presented and compared with similar approaches and significant conclusions are drawn. Based on the analysis there are some countries that signify high yearly wind energy yield, such as South Africa, Sudan, Algeria, Egypt, Libya, Nigeria, Mauritania, Tunisia and Morocco, whilst Equatorial Guinea, Gabon, Central African Republic, Burundi, Liberia, Benin and Togo indicate the least wind power potential.
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| 25. |
- Mentis, Dimitris, et al.
(författare)
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Lighting the World : the first application of an open source, spatial electrification tool (OnSSET) on Sub-Saharan Africa
- 2017
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Ingår i: Environmental Research Letters. - : Institute of Physics Publishing (IOPP). - 1748-9326. ; 12:8
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Tidskriftsartikel (refereegranskat)abstract
- In September 2015, the United Nations General Assembly adopted Agenda 2030, which comprises a set of 17 Sustainable Development Goals (SDGs) defined by 169 targets. 'Ensuring access to affordable, reliable, sustainable and modern energy for all by 2030' is the seventh goal (SDG7). While access to energy refers to more than electricity, the latter is the central focus of this work. According to the World Bank's 2015 Global Tracking Framework, roughly 15% of the world's population (or 1.1 billion people) lack access to electricity, and many more rely on poor quality electricity services. The majority of those without access (87%) reside in rural areas. This paper presents results of a geographic information systems approach coupled with open access data. We present least-cost electrification strategies on a country-by-country basis for Sub-Saharan Africa. The electrification options include grid extension, mini-grid and stand-alone systems for rural, peri-urban, and urban contexts across the economy. At low levels of electricity demand there is a strong penetration of standalone technologies. However, higher electricity demand levels move the favourable electrification option from stand-alone systems to mini grid and to grid extensions.
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| 26. |
- Meyer, E., et al.
(författare)
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The state of the art in beyond 5G distributed massive multiple-input multiple-output communication system solutions
- 2022
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Ingår i: Open Research Europe. - : F1000 Research Ltd. - 2732-5121. ; 2
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Forskningsöversikt (refereegranskat)abstract
- Beyond fifth generation (5G) communication systems aim towards data rates in the tera bits per second range, with improved and flexible coverage options, introducing many new technological challenges in the fields of network architecture, signal pro- cessing, and radio frequency front-ends. One option is to move towards cell-free, or distributed massive Multiple-Input Multiple-Output (MIMO) network architectures and highly integrated front-end solutions. This paper presents an outlook on be- yond 5G distributed massive MIMO communication systems, the signal processing, characterisation and simulation challenges, and an overview of the state of the art in millimetre wave antennas and electronics.
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| 27. |
- Otto, Thomas D., et al.
(författare)
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A comprehensive evaluation of rodent malaria parasite genomes and gene expression
- 2014
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Ingår i: BMC Biology. - : BioMed Central. - 1741-7007. ; 12
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Rodent malaria parasites (RMP) are used extensively as models of human malaria. Draft RMP genomes have been published for Plasmodium yoelii, P. berghei ANKA (PbA) and P. chabaudi AS (PcAS). Although availability of these genomes made a significant impact on recent malaria research, these genomes were highly fragmented and were annotated with little manual curation. The fragmented nature of the genomes has hampered genome wide analysis of Plasmodium gene regulation and function.RESULTS: We have greatly improved the genome assemblies of PbA and PcAS, newly sequenced the virulent parasite P. yoelii YM genome, sequenced additional RMP isolates/lines and have characterized genotypic diversity within RMP species. We have produced RNA-seq data and utilised it to improve gene-model prediction and to provide quantitative, genome-wide, data on gene expression. Comparison of the RMP genomes with the genome of the human malaria parasite P. falciparum and RNA-seq mapping permitted gene annotation at base-pair resolution. Full-length chromosomal annotation permitted a comprehensive classification of all subtelomeric multigene families including the 'Plasmodium interspersed repeat genes' (pir). Phylogenetic classification of the pir family, combined with pir expression patterns, indicates functional diversification within this family.CONCLUSIONS: Complete RMP genomes, RNA-seq and genotypic diversity data are excellent and important resources for gene-function and post-genomic analyses and to better interrogate Plasmodium biology. Genotypic diversity between P. chabaudi isolates makes this species an excellent parasite to study genotype-phenotype relationships. The improved classification of multigene families will enhance studies on the role of (variant) exported proteins in virulence and immune evasion/modulation.
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| 28. |
- Ramos, Eunice, et al.
(författare)
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The role of energy efficiency in the management of water resources of the Syr Darya River basin
- 2021
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Ingår i: International Journal of Environment and Sustainable Development (IJESD). - : INDERSCIENCE ENTERPRISES LTD. - 1474-6778 .- 1478-7466. ; 20:1, s. 64-88
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Tidskriftsartikel (refereegranskat)abstract
- A motivation for integrated resource assessments is that they can capture indirect cross-sectoral effects of sectoral policies. This work investigates the electricity system implications from the implementation of basin-wide electricity and water systems efficiency measures. The spatial scope includes the four states that share the Syr Darya River basin. Different interests dictate the management of water resources in the basin. They are necessary for irrigation downstream in spring and summer and upstream, for hydropower generation during winter. The study investigated options to decrease the need for electricity upstream through efficiency measures and by the expansion of regional electricity trade. The scenarios were simulated by developing a multi-country electricity system model using the open source energy modelling system (OSeMOSYS). The results show that lesser investments in hydropower capacity could be needed and less water required in winter. This would reduce pressure on shared water resources.
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| 29. |
- Sammen, Saad Sh., et al.
(författare)
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Assessment of climate change impact on probable maximum floods in a tropical catchment
- 2022
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Ingår i: Journal of Theoretical and Applied Climatology. - : Springer. - 0177-798X .- 1434-4483. ; 148:1-2, s. 15-31
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Tidskriftsartikel (refereegranskat)abstract
- The increases in extreme rainfall could increase the probable maximum flood (PMF) and pose a severe threat to the critical hydraulic infrastructure such as dams and flood protection structures. This study is conducted to assess the impact of climate change on PMF in a tropical catchment. Climate and inflow data of the Tenmengor reservoir, located in the state of Perak in Malaysia, have been used to calibrate and validate the hydrological model. The projected rainfall from regional climate model is used to generate probable maximum precipitation (PMP) for future periods. A hydrological model was used to simulate PMF from PMP estimated for the historical and two future periods, early (2031 − 2045) and late (2060 − 2075). The results revealed good performance of the hydrological model with Nash–Sutcliffe efficiency, 0.74, and the relative standard error, 0.51, during validation. The estimated rainfall depths were 89.5 mm, 106.3 mm, and 143.3 mm, respectively, for 5, 10, and 50 years of the return period. The study indicated an increase in PMP by 162% to 507% and 259% to 487% during early and late periods for different return periods ranging from 5 to 1000 years. This would cause an increase in PMF by 48.9% and 122.6% during early and late periods. A large increase in PMF indicates the possibility of devastating floods in the future in his tropical catchment due to climate change.
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| 30. |
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| 31. |
- Siyal, Shahid Hussain, et al.
(författare)
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Mapping key economic indicators of onshore wind energy in Sweden by using a geospatial methodology
- 2016
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Ingår i: Energy Conversion and Management. - : Elsevier. - 0196-8904 .- 1879-2227. ; 128, s. 211-226
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Tidskriftsartikel (refereegranskat)abstract
- Due to modern advancements in renewable energy systems and increasing prices of fossil fuels wind energy is getting a lot of attention all over the world. In this regard, Sweden also fixed motivated targets to get energy supply from local renewable energy resources. So, local wind power could help the country in achieving the targets. In this study, economic indicators of wind energy were spatially estimated for Sweden by using ArcGIS tool. In order to do this, as input data one-year high resolution modeled annual average wind data was processed by means of Rayleigh distribution, wind turbine power curve, land use constraints, technical constraints and economic parameters. Based on the input data, it was concluded that Sweden possesses economically feasible wind energy resource. The results of the study indicate that southern and central regions could produce economically viable wind electricity in all aspects as compared to the northern region of the country. Lastly, it was recommended to speed up wind energy penetration in Sweden, communal awareness and acceptance regarding the resource should be increased to avoid possible misunderstanding. Additionally, the capability of the national electric grid should be enhanced to take up the large scale unpredictable wind energy resource.
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| 32. |
- Siyal, Shahid Hussain, 1980-
(författare)
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Techno-economic assessment of wind energy for renewable hydrogen production in Sweden
- 2019
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Wind energy deployment has been growing globally. The resource is expected to play an important role in achieving economic and environmental sustainability - depending on its level of availability, economics, and policy. Sweden has committed to have 20 TWh/year production of onshore wind energy in the national electricity sector by the year 2020. Further, Sweden has a target for a fossil fuel free transport sector by 2030. Local wind energy coupled to electrolysis-derived hydrogen fuel production offers a pathway for achieving both targets. The analysis of wind energy’s potential in this context necessitates a new type of approach, one that captures the complexities of wind turbine siting in relation to the build-up of hydrogen infrastructure, including refueling stations. In this thesis, high-resolution spatial assessments were performed to evaluate wind energy and wind-to-hydrogen energy potentials, including land use restrictions and techno-economic evaluations. The methodology combines analysis with Geographic Information System (GIS) data and the Hybrid Optimization Model for Multiple Energy Resources (HOMER) tool and includes key constraints with the purpose of improving the fidelity of the assessments.Overall, significant potentials for wind and hydrogen energy might be harnessed in Sweden. Wind-generated hydrogen can be produced cost-effectively at selected sites along existing roads. After applying a large array of land use restrictions, results show that around 31% of the total land area is viable for wind energy applications in the country. In total, 190 TWh/year wind electricity could be generated in areas within 30 km from the national electricity grid. Moreover, approximately 25580 kton/year of hydrogen fuel could be supplied by installing wind turbines on the viable land area. While considering standalone wind-powered hydrogen refueling stations, the cost of hydrogen lies in the range of 6-10 USD∕kg, depending on wind speed models employed and other factors. Note that this study does not evaluate how these new wind or hydrogen production potentials might be integrated into the energy sector.
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| 33. |
- Tao, Hai, et al.
(författare)
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Groundwater level prediction using machine learning models: A comprehensive review
- 2022
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Ingår i: Neurocomputing. - : Elsevier. - 0925-2312 .- 1872-8286. ; 489, s. 271-308
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Forskningsöversikt (refereegranskat)abstract
- Developing accurate soft computing methods for groundwater level (GWL) forecasting is essential for enhancing the planning and management of water resources. Over the past two decades, significant progress has been made in GWL prediction using machine learning (ML) models. Several review articles have been published, reporting the advances in this field up to 2018. However, the existing review articles do not cover several aspects of GWL simulations using ML, which are significant for scientists and practitioners working in hydrology and water resource management. The current review article aims to provide a clear understanding of the state-of-the-art ML models implemented for GWL modeling and the milestones achieved in this domain. The review includes all of the types of ML models employed for GWL modeling from 2008 to 2020 (138 articles) and summarizes the details of the reviewed papers, including the types of models, data span, time scale, input and output parameters, performance criteria used, and the best models identified. Furthermore, recommendations for possible future research directions to improve the accuracy of GWL prediction models and enhance the related knowledge are outlined.
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| 34. |
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| 35. |
- Xiao, Ming, 1975-, et al.
(författare)
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Millimeter Wave Communications for Future Mobile Networks
- 2017
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Ingår i: IEEE Journal on Selected Areas in Communications. - : Institute of Electrical and Electronics Engineers (IEEE). - 0733-8716 .- 1558-0008. ; 35:9, s. 1909-1935
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Tidskriftsartikel (refereegranskat)abstract
- Millimeter wave (mmWave) communications have recently attracted large research interest, since the huge available bandwidth can potentially lead to the rates of multiple gigabit per second per user. Though mmWave can be readily used in stationary scenarios, such as indoor hotspots or backhaul, it is challenging to use mmWave in mobile networks, where the transmitting/receiving nodes may be moving, channels may have a complicated structure, and the coordination among multiple nodes is difficult. To fully exploit the high potential rates of mmWave in mobile networks, lots of technical problems must be addressed. This paper presents a comprehensive survey of mmWave communications for future mobile networks (5G and beyond). We first summarize the recent channel measurement campaigns and modeling results. Then, we discuss in detail recent progresses in multiple input multiple output transceiver design for mmWave communications. After that, we provide an overview of the solution for multiple access and backhauling, followed by the analysis of coverage and connectivity. Finally, the progresses in the standardization and deployment of mmWave for mobile networks are discussed.
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| 36. |
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