| 1. |
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| 2. |
- Beal, Jacob, et al.
(författare)
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Robust estimation of bacterial cell count from optical density
- 2020
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Ingår i: Communications Biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 3:1
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Tidskriftsartikel (refereegranskat)abstract
- Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data.
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| 3. |
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| 4. |
- Klionsky, Daniel J., et al.
(författare)
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Guidelines for the use and interpretation of assays for monitoring autophagy
- 2012
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Ingår i: Autophagy. - : Informa UK Limited. - 1554-8635 .- 1554-8627. ; 8:4, s. 445-544
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Forskningsöversikt (refereegranskat)abstract
- In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
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| 5. |
- Campbell, PJ, et al.
(författare)
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Pan-cancer analysis of whole genomes
- 2020
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 578:7793, s. 82-
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Tidskriftsartikel (refereegranskat)abstract
- Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale1–3. Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4–5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter4; identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation5,6; analyses timings and patterns of tumour evolution7; describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity8,9; and evaluates a range of more-specialized features of cancer genomes8,10–18.
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| 6. |
- Huang, Yue, et al.
(författare)
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Memory Effect of Metal-Oxide-Silicon Capacitors with Self-Assembly Double-Layer Au Nanocrystals Embedded in Atomic-Layer-Deposited HfO2 Dielectric
- 2009
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Ingår i: Chinese Physics Letters. - 0256-307X .- 1741-3540. ; 26:10
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Tidskriftsartikel (refereegranskat)abstract
- We report the chemical self-assembly growth of Au nanocrystals on atomic-layer-deposited HfO2 films aminosilanized by (3-Aminopropyl)-trimethoxysilane aforehand for memory applications. The resulting Au nanocrystals show a density of about 4 x 10(11) cm(-2) and a diameter range of 5-8 nm. The metal-oxide-silicon capacitor with double-layer Au nanocrystals embedded in HfO2 dielectric exhibits a large C - V hysteresis window of 11.9 V for +/- 11 V gate voltage sweeps at 1 MHz, a flat-band voltage shift of 1.5 V after the electrical stress under 7 V for 1 ms, a leakage current density of 2.9 x 10(-8) A/cm(-2) at 9 V and room temperature. Compared to single-layer Au nanocrystals, the double-layer Au nanocrystals increase the hysteresis window significantly, and the underlying mechanism is thus discussed.
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| 7. |
- Jin, Ying-Hui, et al.
(författare)
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Chemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19 : An evidence-based clinical practice guideline (updated version)
- 2020
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Ingår i: Military Medical Research. - : Springer Science and Business Media LLC. - 2054-9369. ; 7:1
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Tidskriftsartikel (refereegranskat)abstract
- The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a rapidly spreading illness, coronavirus disease 2019 (COVID-19), affecting more than seventeen million people around the world. Diagnosis and treatment guidelines for clinicians caring for patients are needed. In the early stage, we have issued "A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version)"; now there are many direct evidences emerged and may change some of previous recommendations and it is ripe for develop an evidence-based guideline. We formed a working group of clinical experts and methodologists. The steering group members proposed 29 questions that are relevant to the management of COVID-19 covering the following areas: chemoprophylaxis, diagnosis, treatments, and discharge management. We searched the literature for direct evidence on the management of COVID-19, and assessed its certainty generated recommendations using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach. Recommendations were either strong or weak, or in the form of ungraded consensus-based statement. Finally, we issued 34 statements. Among them, 6 were strong recommendations for, 14 were weak recommendations for, 3 were weak recommendations against and 11 were ungraded consensus-based statement. They covered topics of chemoprophylaxis (including agents and Traditional Chinese Medicine (TCM) agents), diagnosis (including clinical manifestations, reverse transcription-polymerase chain reaction (RT-PCR), respiratory tract specimens, IgM and IgG antibody tests, chest computed tomography, chest x-ray, and CT features of asymptomatic infections), treatments (including lopinavir-ritonavir, umifenovir, favipiravir, interferon, remdesivir, combination of antiviral drugs, hydroxychloroquine/chloroquine, interleukin-6 inhibitors, interleukin-1 inhibitors, glucocorticoid, qingfei paidu decoction, lianhua qingwen granules/capsules, convalescent plasma, lung transplantation, invasive or noninvasive ventilation, and extracorporeal membrane oxygenation (ECMO)), and discharge management (including discharge criteria and management plan in patients whose RT-PCR retesting shows SARS-CoV-2 positive after discharge). We also created two figures of these recommendations for the implementation purpose. We hope these recommendations can help support healthcare workers caring for COVID-19 patients.
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| 8. |
- Liao, Zhong-Wei, et al.
(författare)
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Robust Low Voltage Program-Erasable Cobalt-Nanocrystal Memory Capacitors with Multistacked Al2O3/HfO2/Al2O3 Tunnel Barrier
- 2009
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Ingår i: Chinese Physics Letters. - 0256-307X .- 1741-3540. ; 26:8, s. 087303-
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Tidskriftsartikel (refereegranskat)abstract
- An atomic-layer-deposited Al2O3/HfO2/Al2O3 (A/H/A) tunnel barrier is investigated for Co nanocrystal memory capacitors. Compared to a single Al2O3 tunnel barrier, the A/H/A barrier can significantly increase the hysteresis window, i. e., an increase by 9V for +/- 12V sweep range. This is attributed to a marked decrease in the energy barriers of charge injections for the A/H/A tunnel barrier. Further, the Co-nanocrystal memory capacitor with the A/H/A tunnel barrier exhibits a memory window as large as 4.1V for 100 mu s program/erase at a low voltage of +/- 7V, which is due to fast charge injection rates, i. e., about 2.4 x 10(16) cm(-2) s(-1) for electrons and 1.9 x 10(16) cm(-2) s(-1) for holes.
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| 9. |
- Peng, Shi-Yu, et al.
(författare)
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Reduced motor cortex GABABR function following chronic alcohol exposure
- 2021
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Ingår i: Molecular Psychiatry. - : SPRINGERNATURE. - 1359-4184 .- 1476-5578. ; 26:2, s. 383-395
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Tidskriftsartikel (refereegranskat)abstract
- The GABA(B) receptor (GABA(B)R) agonist baclofen has been used to treat alcohol and several other substance use disorders (AUD/SUD), yet its underlying neural mechanism remains unclear. The present study aimed to investigate cortical GABA(B)R dynamics following chronic alcohol exposure. Ex vivo brain slice recordings from mice chronically exposed to alcohol revealed a reduction in GABA(B)R-mediated currents, as well as a decrease of GABA(B1/2)R and G-protein-coupled inwardly rectifying potassium channel 2 (GIRK2) activities in the motor cortex. Moreover, our data indicated that these alterations could be attributed to dephosphorylation at the site of serine 783 (ser-783) in GABA(B2) subunit, which regulates the surface expression of GABA(B)R. Furthermore, a human study using paired-pulse-transcranial magnetic stimulation (TMS) analysis further demonstrated a reduced cortical inhibition mediated by GABA(B)R in patients with AUD. Our findings provide the first evidence that chronic alcohol exposure is associated with significantly impaired cortical GABA(B)R function. The ability to promote GABA(B)R signaling may account for the therapeutic efficacy of baclofen in AUD.
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| 10. |
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| 11. |
- Wang, Tingting, et al.
(författare)
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Prevalence and influencing factors of wheeze and asthma among preschool children in Urumqi city : a cross-sectional survey
- 2023
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Ingår i: Scientific Reports. - : Springer Nature. - 2045-2322. ; 13:1
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Tidskriftsartikel (refereegranskat)abstract
- To investigate the prevalence and indoor environmental influencing factors of wheeze and asthma among preschool children in Urumqi, Xinjiang, China to provide a strong basis for prevention and control. In August 2019, a cross-sectional study involving 8153 preschool children was conducted in 60 kindergartens in Urumqi. The ALLHOME-2 questionnaire was used for childhood wheeze and asthma survey, and the dampness in buildings and health (DBH) questionnaire was used for the childhood home dwelling and living environment survey. Multivariate unconditional logistic regression was then used to analyze the potential influencing factors of childhood asthma and wheeze. The prevalence of wheeze and asthma in children was 4.7% and 2.0%, respectively. Multivariate unconditional logistic regression results suggested that ethnicity other than the Han Chinese (odds ratio (OR) 1.39, 95% confidence interval (CI) 1.05-1.84), caesarean section (OR 1.24, 95% CI 1.00-1.53), family history of asthma (OR 5.00, 95% CI 3.36-7.44), carpet or floor bedding at home (OR 1.40, 95% CI 1.05-1.87), purchasing new furniture in the mother's residence during pregnancy (OR 1.58, 95% CI 1.06-2.36), pet keeping in the residence at aged 0-1 year (OR 1.55, 95% CI 1.13-2.13), passive smoking by child in the current residence (OR 1.35, 95% CI 1.01-1.80), and having mould or hygroma in the child's residence at aged 0-1 year (OR 1.72, 95% CI 1.12-2.64) were risk factors for wheeze. In addition, Girls (OR 0.73, 95% CI 0.59-0.90) was a protective factor for wheeze. Caesarean section (OR 1.46, 95% CI 1.06-2.00), family history of asthma (OR 7.06, 95% CI 4.33-11.53), carpet or floor bedding at home (OR 2.20, 95% CI 1.50-3.23), and pet keeping in the residence at aged 0-1 year (OR 1.64, 95% CI 1.04-1.83) were risk factors for asthma, whereas Girls (OR 0.58, 95% CI 0.42-0.80) was a protective factor for asthma. This survey indicates that the purchase of new furniture, the placement of carpet or floor bedding in the child's residence, the pets keeping, room dampness or moldy phenomena, and passive smoking may all contribute to an elevated risk of wheeze or asthma in children.
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| 12. |
- Zhang, L., et al.
(författare)
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Effects of intense laser irradiation on Raman intensity features of carbon nanotubes
- 2002
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Ingår i: Physical Review B. Condensed Matter and Materials Physics. - 1098-0121 .- 1550-235X. ; 65:7
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Tidskriftsartikel (refereegranskat)abstract
- The effect of intense laser irradiation on the features of Raman intensity of carbon nanotubes (CNT's) has been examined. The intensity of the D band decreases and the relative intensity between the G peaks changes with increasing laser power density (LPD) and remain unchanged with subsequent decrease in LPD. This behavior is different from the reversible variation of the G band frequency in the same process of power increase and subsequent decrease. It has been demonstrated that such irreversible change in intensity features originates from sample purification. This result suggests a simple and fast CNT purification method using intense laser irradiation.
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| 13. |
- Zhang, Shi-Li, et al.
(författare)
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Abnormal anti-Stokes Raman scattering of carbon nanotubes
- 2002
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Ingår i: Physical Review B. Condensed Matter and Materials Physics. - 1098-0121 .- 1550-235X. ; 66:3
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Tidskriftsartikel (refereegranskat)abstract
- Abnormal anti-Stokes Raman scattering (AASR) was unambiguously observed in carbon nanotubes (CNT's). In contrast to traditional Raman scattering theory, the absolute value of the Raman frequency of the anti-Stokes peak is not the same as that of the corresponding Stokes peak. It was demonstrated that AASR scattering originates from the unique nanoscale cylindrical structure of CNT's that can be considered naturally as a graphite structure with an intrinsic defect from its rolling. The double-resonance Raman scattering theory was applied to interpret the scattering mechanism of the AASR phenomenon successfully and quantitatively.
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| 14. |
- Ai, Yue-Jie, 1982-, et al.
(författare)
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Repair of DNA Dewar Photoproduct to (6-4) photoproduct in (6-4) Photolyase
- 2011
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Ingår i: Journal of Physical Chemistry B. - : American Chemical Society (ACS). - 1520-6106 .- 1520-5207. ; 115:37, s. 10976-10982
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Tidskriftsartikel (refereegranskat)abstract
- Dewar photoproduct (Dewar PP) is the valence isomer of (6-4) photoproduct ((6-4)PP) in photodamaged DNA. Compared to the extensive studied CPD photoproducts, the underlying repair mechanisms for the (6-4)PP, and especially for the Dewar PP, are not well-established to date. In this paper, the repair mechanism of DNA Dewar photoproduct T(dew)C in (6-4) photolyase was elucidated using hybrid density functional theory. Our results showed that, during the repair process, the T(dew)C has to isomerize to T(6-4)C photolesion first via direct C6'-N3' bond cleavage facilitated by electron injection. This isomerization mechanism is energetically much more efficient than other possible rearrangement pathways. The calculations provide a theoretical interpretation to recent experimental observations.
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| 15. |
- Forsberg, U., et al.
(författare)
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Recoil-α-fission and recoil-α-α-fission events observed in the reaction 48Ca + 243Am
- 2016
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Ingår i: Nuclear Physics, Section A. - : Elsevier BV. - 0375-9474. ; 953, s. 117-138
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Tidskriftsartikel (refereegranskat)abstract
- Products of the fusion-evaporation reaction 48Ca + 243Am were studied with the TASISpec set-up at the gas-filled separator TASCA at the GSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, Germany. Amongst the detected thirty correlated α-decay chains associated with the production of element Z=115, two recoil-α-fission and five recoil-α-α-fission events were observed. The latter five chains are similar to four such events reported from experiments performed at the Dubna gas-filled separator, and three such events reported from an experiment at the Berkeley gas-filled separator. The four chains observed at the Dubna gas-filled separator were assigned to start from the 2n-evaporation channel 289115 due to the fact that these recoil-α-α-fission events were observed only at low excitation energies. Contrary to this interpretation, we suggest that some of these recoil-α-α-fission decay chains, as well as some of the recoil-α-α-fission and recoil-α-fission decay chains reported from Berkeley and in this article, start from the 3n-evaporation channel 288115.
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| 16. |
- Fu, Chaochao, et al.
(författare)
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Understanding the microwave annealing of silicon
- 2017
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Ingår i: AIP Advances. - : AMER INST PHYSICS. - 2158-3226. ; 7:3
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Tidskriftsartikel (refereegranskat)abstract
- Though microwave annealing appears to be very appealing due to its unique features, lacking an in-depth understanding and accurate model hinder its application in semiconductor processing. In this paper, the physics-based model and accurate calculation for the microwave annealing of silicon are presented. Both thermal effects, including ohmic conduction loss and dielectric polarization loss, and non-thermal effects are thoroughly analyzed. We designed unique experiments to verify the mechanism and extract relevant parameters. We also explicitly illustrate the dynamic interaction processes of the microwave annealing of silicon. This work provides an in-depth understanding that can expedite the application of microwave annealing in semiconductor processing and open the door to implementing microwave annealing for future research and applications.
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| 17. |
- Ge, Yue, et al.
(författare)
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Environmental OMICS: Current Status and Future Directions
- 2013
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Ingår i: JOURNAL OF INTEGRATED OMICS. - : Proteomass Scientific Society. - 2182-0287. ; 3:2, s. 75-87
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Tidskriftsartikel (refereegranskat)abstract
- Applications of OMICS to high throughput studies of changes of genes, RNAs, proteins, metabolites, and their associated functionsin cells or organisms exposed to environmental chemicals has led to the emergence of a very active research field: environmental OMICS.This developing field holds an important key for improving the scientific basis for understanding the potential impacts of environmentalchemicals on both health and the environment. Here we describe the state of environmental OMICS with an emphasis on its recent accomplishmentsand its problems and potential solutions to facilitate the incorporation of OMICS into mainstream environmental and healthresearch.Data sources: We reviewed relevant and recently published studies on the applicability and usefulness of OMICS technologies to the identificationof toxicity pathways, mechanisms, and biomarkers of environmental chemicals for environmental and health risk monitoring andassessment, including recent presentations and discussions on these issues at The First International Conference on Environmental OMICS(ICEO), held in Guangzhou, China during November 8-12, 2011. This paper summarizes our review.Synthesis: Environmental OMICS aims to take advantage of powerful genomics, transcriptomics, proteomics, and metabolomics tools toidentify novel toxicity pathways/signatures/biomarkers so as to better understand toxicity mechanisms/modes of action, to identify/categorize/prioritize/screen environmental chemicals, and to monitor and predict the risks associated with exposure to environmental chemicalson human health and the environment. To improve the field, some lessons learned from previous studies need to be summarized, aresearch agenda and guidelines for future studies need to be established, and a focus for the field needs to be developed.Conclusions: OMICS technologies for identification of RNA, protein, and metabolic profiles and endpoints have already significantly improvedour understanding of how environmental chemicals affect our ecosystem and human health. OMICS breakthroughs are empoweringthe fields of environmental toxicology, chemical toxicity characterization, and health risk assessment. However, environmental OMICS is stillin the data generation and collection stage. Important data gaps in linking and/or integrating toxicity data with OMICS endpoints/profilesneed to be filled to enable understanding of the potential impacts of chemicals on human health and the environment. It is expected thatfuture environmental OMICS will focus more on real environmental issues and challenges such as the characterization of chemical mixturetoxicity, the identification of environmental and health biomarkers, and the development of innovative environmental OMICS approachesand assays. These innovative approaches and assays will inform chemical toxicity testing and prediction, ecological and health risk monitoringand assessment, and natural resource utilization in ways that maintain human health and protects the environment in a sustainable manner.
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| 18. |
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| 19. |
- Gustafsson, Björn, 1948, et al.
(författare)
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Income Inequality and Spatial Differences in China
- 2020
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Ingår i: Research on China’s Income Distribution and Labor Market (Vol.1, Ch.17). - Beijing, P R China : China Human Resources & Social Security Publishing Group Co., Ltd. - 9787516743171 ; , s. 405-431
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Bokkapitel (refereegranskat)
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| 20. |
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| 21. |
- Kang, Nai-xin, et al.
(författare)
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Anemoside B4 inhibits enterovirus 71 propagation in mice through upregulating 14-3-3 expression and type I interferon responses
- 2022
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Ingår i: Acta Pharmacologica Sinica. - : Springer Nature. - 1671-4083 .- 1745-7254. ; 43, s. 977-991
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Tidskriftsartikel (refereegranskat)abstract
- Enterovirus 71 (EV71) is the major pathogens of human hand, foot, and mouth disease (HFMD). EV71 efficiently escapes innate immunity responses of the host to cause infection. At present, no effective antiviral drugs for EV71 are available. Anemoside B4 (B4) is a natural saponin isolated from the roots of Pulsatilla chinensis (Bunge) Regel. P. chinensis extracts that shows a wide variety of biological activities. In this study, we investigated the antiviral activities of B4 against EV71 both in cell culture and in suckling mice. We showed that B4 (12.5-200 mu M) dose dependently increased the viability of EV71-infected RD cells with an IC50 value of 24.95 +/- 0.05 mu M against EV71. The antiviral activity of B4 was associated with enhanced interferon (IFN)-beta response, since knockdown of IFN-beta abolished its antiviral activity. We also confirmed that the enhanced IFN response was mediated via activation of retinoic acid-inducible gene I (RIG-I) like receptors (RLRs) pathway, and it was executed by upregulation of 14-3-3 protein, which disrupted the interaction between yes-associated protein (YAP) and interferon regulatory factor 3 (IRF3). By using amino acids in cell culture (SILAC)-based proteomics profiling, we identified the Hippo pathway as the top-ranking functional cluster in B4-treated EV71-infected cells. In vivo experiments were conducted in suckling mice (2-day-old) infected with EV71 and subsequently B4 (200 mg center dot kg(-1) center dot d(-1), i.p.) was administered for 16 days. We showed that B4 administration effectively suppressed EV71 replication and improved muscle inflammation and limb activity. Meanwhile, B4 administration regulated the expressions of HFMD biomarkers IL-10 and IFN-gamma, attenuating complications of EV71 infection. Collectively, our results suggest that B4 could enhance the antiviral effect of IFN-beta by orchestrating Hippo and RLRs pathway, and B4 would be a potential lead compound for developing an anti-EV71 drug.
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| 22. |
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| 23. |
- Li, Ruiyun, et al.
(författare)
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Operando Formation of Van der Waals Heterostructures for Achieving Macroscale Superlubricity on Engineering Rough and Worn Surfaces
- 2022
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Ingår i: Advanced Functional Materials. - : John Wiley & Sons. - 1616-301X .- 1616-3028. ; 32:18
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Tidskriftsartikel (refereegranskat)abstract
- Macroscale superlubricity breakdown of lubricating materials caused by substrate surface roughening and mechanochemical modification poses great challenges for their practical tribological applications. Here, a facile way is reported to access robust macroscale superlubricity in a vacuum environment, via the operando formation of graphene/transition-metal dichalcogenide (TMDC) heterostructures at wear-induced rough surfaces. By trapping active amorphous carbon (a-C) wear products between TMDC flakes, the sandwich structures readily transform into graphene/TMDC heterostructures during running-in stage, based on shear-induced confinement and load-driven graphitization effects. Then they assemble into multipoint flake-like tribofilms to achieve macroscale superlubricity at steady stage by reducing contact area, eliminating strong cross-interface carbon–carbon interactions and polishing a-C rough nascent surface. Atomistic simulations reveal the preferential formation of graphene/TMDC heterostructures during running-in stage and demonstrate the superlubric sliding of TMDCs on the graphene. The findings are of importance to achieve robust superlubricity and provide a good strategy for the synthesis of other van der Waals heterostructures.
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| 24. |
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| 25. |
- Shi, Fangzhong, et al.
(författare)
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Seasonal compensation implied no weakening of the land carbon sink in the Northern Hemisphere under the 2015/2016 El Niño
- 2024
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Ingår i: Science China Earth Sciences. - 1674-7313 .- 1869-1897. ; 67:1, s. 294-308
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Tidskriftsartikel (refereegranskat)abstract
- The recurrent extreme El Niño events are commonly linked to reduced vegetation growth and the land carbon sink over many but discrete regions of the Northern Hemisphere (NH). However, we reported here a pervasive and continuous vegetation greening and no weakened land carbon sink in the maturation phase of the 2015/2016 El Niño event over the NH (mainly in the extra-tropics), based on multiple evidences from remote sensing observations, global ecosystem model simulations and atmospheric CO2 inversions. We discovered a significant compensation effect of the enhanced vegetation growth in spring on subsequent summer/autumn vegetation growth that sustained vegetation greening and led to a slight increase in the land carbon sink over the spring and summer of 2015 (average increases of 23.34% and 0.63% in net ecosystem exchange from two independent datasets relative to a 5-years average before the El Niño event, respectively) and spring of 2016 (6.82%), especially in the extra-tropics of the NH, where the water supply during the pre-growing-season (November of the previous year to March of the current year) had a positive anomaly. This seasonal compensation effect was much stronger than that in 1997 and 1998 and significantly alleviated the adverse impacts of the 2015/2016 El Niño event on vegetation growth during its maturation phase. The legacy effect of water supply during the pre-growing-season on subsequent vegetation growth lasted up to approximately six months. Our findings highlight the role of seasonal compensation effects on mediating the land carbon sink in response to episodic extreme El Niño events.
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| 26. |
- Shi, Hang, et al.
(författare)
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A Free Stale Synchronous Parallel Strategy for Distributed Machine Learning
- 2019
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Ingår i: BDE 2019. - New York, NY, USA : Association for Computing Machinery (ACM). ; , s. 23-29
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Konferensbidrag (refereegranskat)abstract
- With the machine learning applications processing larger and more complex data, people tend to use multiple computing nodes to execute the machine learning tasks in distributed way. However, in real world, people always encounter a problem that a few nodes in system exhibit poor performance and drag down the efficiency of the whole system. In existing parallel strategies such as bulk synchronous parallel and stale synchronous parallel, these nodes with poor performance may not be monitored and found out in time. To address this problem, we proposed a free stale synchronous parallel (FSSP) strategy to free the system from the negative impact of those nodes. Our experimental results on some classical machine leaning algorithms and datasets demonstrated that FSSP strategy outperformed other existing parallel computing strategy.
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| 27. |
- Shi, Lin Jun, et al.
(författare)
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Construct validity of the simplified Chinese version of the instrument ‘Picture My Participation’
- 2024
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Ingår i: Scandinavian Journal of Occupational Therapy. - : Taylor & Francis. - 1103-8128 .- 1651-2014. ; 31:1
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundPreliminary evidence of the content validity of the simplified Chinese version of ‘Picture My Participation’ (PMP-C; Simplified) items and reliability of the subscale attendance for the effectiveness of the use with children and youth in mainland China has been collected. However, evidence of construct validity for the instrument is not yet available.Aim To explore the construct validity of the attendance scale in PMP-C (Simplified).MethodsA cross-sectional study using convenience sampling was conducted using PMP-C (Simplified) with a picture-supported interview for 290 children and youths aged 5–21 with and without ID in urban and rural areas of mainland China. Exploratory factor analysis (EFA) was performed using the principal component analysis (PCA) to analyse the resulting data.ResultsThe EFA extracted five factors with eigenvalues greater than one and the cumulative contribution rate of factors accounted for 51.62% of the variance. All items had factor loadings above 0.50. The five subcomponents included: organised activities, social activities, taking care of others, family life activities and personal care and development activities.ConclusionThe results of the factor analysis support the construct validity of the PMP-C (Simplified) attendance scale. It provides further psychometric evidence that PMP-C (Simplified) is a sound measure to assess participation for children and youths in mainland China.
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| 28. |
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| 29. |
- Shi, Linjun
(författare)
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Participation in everyday activities among children with intellectual disabilities in mainland China : The development, verification, and application of the Picture My Participation instrument
- 2023
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Background: Participation in everyday activities is seen as a main outcome of rehabilitation for children. ‘Picture My Participation’ (PMP) is a validated questionnaire for assessing participation in everyday activities by children with disabilities in low- and middle-income countries, but it is not yet available in simplified Chinese.Aims: The overall aims of this thesis were to validate a simplified Chinese version of Picture My Participation as a participation assessment tool, the PMP-C (simplified), and also to describe the attendance and involvement in everyday activities of children with IDs and their TD peers in rural and urban areas of mainland China as well as barriers and facilitators of participation from the perspectives of children and their primary caregivers.Methods: This thesis reports four studies conducted to carry out these aims. Studies I and II used a quantitative method with a cross-sectional instrument validation design to cross-culturally adapt the PMP-C (simplified) and explored its validity and reliability. Based on this, Study III used a cross-sectional design to compare the frequency and involvement of children with IDs and TD in everyday activities in rural and urban areas of mainland China. Meanwhile, Study IV used a descriptive and explorative design with an inductive qualitative content analysis approach to describe primary caregivers’ perceptions of barriers and facilitators related to participation in everyday activities among children with IDs in mainland China.Results: All items in the PMP-C (simplified) had excellent content and face validity. The internal consistency, reliability coefficient, and test-retest reliability of the subscale scores were excellent (Study I). The construct validity of the subscale scores extracted five subcomponents: organised activities, social activities, taking care of others, family life activities, and personal care and development activities (Study II). Children with IDs reported lower participation than children with TD in terms of their total scores for attendance and involvement but reported the same levels of involvement in the subcomponents taking care of others and family life activities as children with TD in urban areas. Concerning differences between urban and rural contexts, both children with TD and IDs in rural areas reported lower total scores for attendance and for all subcomponents except social activities than their urban counterparts. There was no significant difference in the total involvement score between rural and urban contexts for children with IDs; however, children with TD in urban areas reported higher involvement than their rural counterparts (Study III). Four categories of barriers to participation in everyday activities for children with IDs were identified: insufficient knowledge, attitudes, and skills in primary caregivers; ID-related characteristics of children; stigma and Chinese culture; and lack of societal support. Four categories describing facilitators were identified: the optimistic attitude of the primary caregiver, adequate family support; active school and policy environments, and enjoyable characteristics of children with IDs (Study IV).Conclusion: This thesis provides psychometric evidence that the PMP-C (simplified) is a valid and reliable measure of participation in mainland China and enable children with ID to have “a voice” and to report their own perspectives. The findings regarding ID–TD and urban–rural disparities in participation and the barriers and facilitators of participation among children with IDs offer important insights concerning environmental aspects when planning future intervention studies focused on promoting participation in mainland China.
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| 30. |
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| 31. |
- Shi, Linjun, et al.
(författare)
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Transcultural adaptation, content validity and reliability of the instrument 'Picture My Participation' for children and youth with and without intellectual disabilities in mainland China
- 2021
-
Ingår i: Scandinavian Journal of Occupational Therapy. - : Taylor & Francis. - 1103-8128 .- 1651-2014. ; 28:2, s. 147-157
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: 'Picture My Participation' (PMP) is a validated questionnaire for assessing participation in everyday activities by children with disabilities in low and middle income countries, but it is not yet available in simplified Chinese.AIM: To describe the cross-cultural adaptation of the simplified Chinese version of 'Picture My Participation' (PMP-C; Simplified) and explore its validity and reliability.METHODS: A cross-sectional study using convenience sampling was conducted using PMP-C (Simplified) with structured interviews supported by pictures for children and youth with and without intellectual disabilities (ID) in mainland China. The validity of the PMP-C (Simplified) was demonstrated by face validity and content validity while the reliability was evaluated for internal consistency and test-retest reliability.RESULTS: Five items were slightly modified and eight pictures were revised to improve their fit with the culture of mainland China. All the items in PMP-C (Simplified) had excellent content validity, and face validity. The internal consistency, reliability coefficient and test-retest reliability of the subscale attendance for children and youth with and without ID were excellent.CONCLUSION: Preliminary evidence of the content validity of PMP-C (Simplified) items and reliability of the subscale attendance for use with children and youth in mainland China has been gathered. However, psychometric properties in terms of construct validity for the whole instrument and reliability for the engagement subscale need further exploration.
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| 32. |
- Shi, Weibo, et al.
(författare)
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Optimizing Observation Plans for Identifying Faxon Fir (Abies fargesii var. Faxoniana) Using Monthly Unmanned Aerial Vehicle Imagery
- 2023
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Ingår i: Remote Sensing. - 2072-4292. ; 15:8
-
Tidskriftsartikel (refereegranskat)abstract
- Faxon fir (Abies fargesii var. faxoniana), as a dominant tree species in the subalpine coniferous forest of Southwest China, has strict requirements regarding the temperature and humidity of the growing environment. Therefore, the dynamic and continuous monitoring of Faxon fir distribution is very important to protect this highly sensitive ecological environment. Here, we combined unmanned aerial vehicle (UAV) imagery and convolutional neural networks (CNNs) to identify Faxon fir and explored the identification capabilities of multispectral (five bands) and red-green-blue (RGB) imagery under different months. For a case study area in Wanglang Nature Reserve, Southwest China, we acquired monthly RGB and multispectral images on six occasions over the growing season. We found that the accuracy of RGB imagery varied considerably (the highest intersection over union (IoU), 83.72%, was in April and the lowest, 76.81%, was in June), while the accuracy of multispectral imagery was consistently high (IoU > 81%). In April and October, the accuracy of the RGB imagery was slightly higher than that of multispectral imagery, but for the other months, multispectral imagery was more accurate (IoU was nearly 6% higher than those of the RGB imagery for June). Adding vegetation indices (VIs) improved the accuracy of the RGB models during summer, but there was still a gap to the multispectral model. Hence, our results indicate that the optimized time of the year for identifying Faxon fir using UAV imagery is during the peak of the growing season when using a multispectral imagery. During the non-growing season, RGB imagery was no worse or even slightly better than multispectral imagery for Faxon fir identification. Our study can provide guidance for optimizing observation plans regarding data collection time and UAV loads and could further help enhance the utility of UAVs in forestry and ecological research.
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| 33. |
- Shi, Yue
(författare)
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Mechanisms of type 1 diabetic serum-induced hyperactivation of CaV1 channels in the pancreatic β cell
- 2016
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The pancreatic β cell relies on appropriate Ca2+ entry through voltage-gated calcium (CaV) channels to accomplish its unique function insulin secretion and to guarantee its viability. Well-regulated β cell CaV channels are critical to ensure adequate functional β cell mass, thereby maintaining adequate insulin release and glucose homeostasis in the body. When β cell CaV channels mediate insufficient or excessive Ca2+ influx due to either inherited or acquired defects, β cell becomes malfunctioning and even dies. Type 1 diabetic (T1D) serum hyperactivates β cell CaV1 channels driving Ca2+-dependent β cell apoptosis via previously unappreciated mechanisms. The present PhD work has mechanistically dissected T1D serum-induced hyperactivation of CaV1 channels in the β cell by combining patchclamp techniques, confocal microscopy, as well as molecular and cellular approaches. It reveals the following findings: Functional CaV1.3 channels reside in 20 % of mouse islet CaV1.2-/- β cells. They characteristically show a large unitary Ba2+ conductance with long-lasting openings in plasma membrane patches of islet cells endowed with undetectable voltage-gated Na+ currents, larger cell capacitance (> 7 pF) and insulin mRNA. These observations pinpoint β cell-specific CaV1.2-/- mice as a convenient small animal model for investigation of human β cell CaV1.3 channel-related disorders such as T1D serum-induced hyperactivation of β cell CaV1.3 channels. T1D serum hyperactivates both CaV1.2 and CaV1.3 channels by elevating their conductivity and number in the β cell plasma membrane. This finding emphasizes that both CaV1.2 and CaV1.3 channels are potential druggable targets for prevention of Ca2+ overload-induced β cell death. Apolipoprotein CIII (ApoCIII) in T1D serum is electrophysiologically validated to be the actual factor enhancing CaV channel currents in the β cell. This validation opens up the possibility to deplete or neutralize ApoCIII in T1D serum for medical intervention of CaV channel hyperactivation-driven β cell destruction. ApoCIII activates both PKA and Src kinase in a scavenger receptor class B type I/β1 integrin-dependent fashion to selectively hyperactivate β cell CaV1 channels without altering β cell CaV1 channel expression. ApoCIII-induced hyperactivation of β cell CaV1 channels results from the enriched density and increased activity of functional CaV1 channels in the β cell plasma membrane. This newly-identified signaling pathway shows great potential as a set of novel druggable targets for prevention of Ca2+-dependent β cell death in association with diabetes. The key endocytic protein syndapin I/PACSIN 1 (PCS1) is richly expressed in β cells to govern endocytic activity. PCS1-mediated endocytosis acts as a homeostatic control system to fine-tune the CaV1 channel density in the β cell plasma membrane. These findings add a new layer of complexity to the mechanisms of β cell CaV1 channel regulation. ApoCIII impairs both constitutive and regulated β cell endocytosis with no influence on PCS1 expression. Consequently, ApoCIII abrogates PCS1-dependent endocytic trafficking, thereby accumulating excessive CaV1 channels in the β cell plasma membrane. These results delineate a novel mechanism of Ca2+-dependent β cell destruction in diabetes development and reveal a promising and attractive option to counteract the critical diabetogenic process of Ca2+-dependent β cell death. Overall, the aforementioned findings depict a mechanistic picture of how ApoCIII renders CaV1 channels highly enriched and excessively activated in the β cell plasma membrane, thereby resulting in pathologically exaggerated Ca2+ influx and Ca2+-dependent β death. These findings lay the foundation for novel treatment strategies for diabetes.
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| 34. |
- Shi, Yue, et al.
(författare)
-
Structure of Superheavy Nuclei Along Decay Chains of Element 115
- 2014
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Ingår i: Physical Review C (Nuclear Physics). - 0556-2813. ; 90:1
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Tidskriftsartikel (refereegranskat)abstract
- A recent high-resolution α, X-ray, and γ-ray coincidence-spectroscopy experiment offered the first glimpse of excitation schemes of isotopes along α-decay chains of Z=115. To understand these observations and to make predictions about shell structure of superheavy nuclei below 288-115, we employ two complementary mean-field models: the self-consistent Skyrme energy density functional approach and the macroscopic-microscopic Nilsson model. We discuss the spectroscopic information carried by the new data. In particular, candidates for the experimentally observed E1 transitions in Mt276 are proposed. We find that the presence and nature of low-energy E1 transitions in well-deformed nuclei around Z=110,N=168 strongly depends on the strength of the spin-orbit coupling; hence, it provides an excellent constraint on theoretical models of superheavy nuclei. To clarify competing theoretical scenarios, an experimental search for E1 transitions in odd-A systems Mt277, Hs275, and Ds277 is strongly recommended.
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| 35. |
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| 36. |
- Sicular, Terry, et al.
(författare)
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How Large is China's Rural-Urban Income Gap?
- 2010
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Ingår i: One Country, Two Societies. Rural-Urban Inequality in Contemporary China. - 9780674036321
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 37. |
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| 38. |
- Sicular, Terry, et al.
(författare)
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The Urban-Rural Income Gap and Inequality in China
- 2007
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Ingår i: Review of Income and Wealth. - 1475-4991. ; 53:1, s. 93-126
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Tidskriftsartikel (refereegranskat)abstract
- Using new and rich data for 1995 and 2002, this study investigates the size of China’s urban-rural income gap, the contribution of that gap to overall inequality in China, and the factors underlying the gap. The analysis improves on past estimates by adjusting for spatial price differences and including migrants. Methods employed include inequality decomposition by population subgroup and the Oaxaca-Blinder decomposition method. Several key findings emerge. First, most estimates of China’s urban-rural income gap and its contribution to overall inequality may be substantially overstated. Second, the Oaxaca-Blinder decomposition reveals that after controlling for household and individual characteristics, location of residence remains the most important factor underlying the urban-rural income gap. The only household characteristic that contributes substantially to the gap is education. Differences in the endowments of, and returns to, other household characteristics such as family size and composition, landholdings, and Party membership are relatively unimportant.
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| 39. |
- Sicular, Terry, et al.
(författare)
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The urban-rural income gap in China
- 2020
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Ingår i: Research on China’s Income Distribution and Labor Market (Vol.1, Ch.12). - Beijing, PR China : China Human Resources & Social Security Publishing Group Co., Ltd. - 9787516743171 ; , s. 291-330
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Bokkapitel (refereegranskat)
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| 40. |
- Tang, Liqiu, et al.
(författare)
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A zeolite family with chiral and achiral structures built from the same building layer
- 2008
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Ingår i: Nature Materials. - : Springer Science and Business Media LLC. - 1476-1122 .- 1476-4660. ; 7:5, s. 381-385
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Tidskriftsartikel (refereegranskat)abstract
- Porosity and chirality are two of the most important properties for materials in the chemical and pharmaceutical industry. Inorganic microporous materials such as zeolites have been widely used in ion-exchange, selective sorption/separation and catalytic processes. The pore size and shape in zeolites play important roles for specific applications(1-3). Chiral inorganic microporous materials are particularly desirable with respect to their possible use in enantioselective sorption, separation and catalysis(4). At present, among the 179 zeolite framework types reported, only three exhibit chiral frameworks(5-7). Synthesizing enantiopure, porous tetrahedral framework structures represents a great challenge for chemists. Here, we report the silicogermanates SU-32 (polymorph A), SU-15 (polymorph B) (SU, Stockholm University) and a hypothetical polymorph C, all built by different stacking of a novel building layer. Whereas polymorphs B and C are achiral, each crystal of polymorph A exhibits only one hand and has an intrinsically chiral zeolite structure. SU-15 and SU-32 are thermally stable on calcination.
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| 41. |
- Wang, Yizhi, et al.
(författare)
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SynQuant : an automatic tool to quantify synapses from microscopy images
- 2020
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Ingår i: Bioinformatics. - : Oxford University Press (OUP). - 1367-4803 .- 1367-4811 .- 1460-2059. ; 36:5, s. 1599-1606
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Tidskriftsartikel (refereegranskat)abstract
- Motivation: Synapses are essential to neural signal transmission. Therefore, quantification of synapses and related neurites from images is vital to gain insights into the underlying pathways of brain functionality and diseases. Despite the wide availability of synaptic punctum imaging data, several issues are impeding satisfactory quantification of these structures by current tools. First, the antibodies used for labeling synapses are not perfectly specific to synapses. These antibodies may exist in neurites or other cell compartments. Second, the brightness of different neurites and synaptic puncta is heterogeneous due to the variation of antibody concentration and synapse-intrinsic differences. Third, images often have low signal to noise ratio due to constraints of experiment facilities and availability of sensitive antibodies. These issues make the detection of synapses challenging and necessitates developing a new tool to easily and accurately quantify synapses.Results: We present an automatic probability-principled synapse detection algorithm and integrate it into our synapse quantification tool SynQuant. Derived from the theory of order statistics, our method controls the false discovery rate and improves the power of detecting synapses. SynQuant is unsupervised, works for both 2D and 3D data, and can handle multiple staining channels. Through extensive experiments on one synthetic and three real datasets with ground truth annotation or manually labeling, SynQuant was demonstrated to outperform peer specialized unsupervised synapse detection tools as well as generic spot detection methods.
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| 42. |
- Wei, Jiang, et al.
(författare)
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17β-estradiol regulates the expression of apolipoprotein M through estrogen receptor α-specific binding motif in its promoter
- 2017
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Ingår i: Lipids in Health and Disease. - : Springer Science and Business Media LLC. - 1476-511X. ; 16:1, s. 1-8
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Tidskriftsartikel (refereegranskat)abstract
- Background: We have previously demonstrated that estrogen could significantly enhance expression of apolipoprotein M (apoM), whereas the molecular basis of its mechanism is not fully elucidated yet. To further investigate the mechanism behind the estrogen induced up-regulation of apoM expression. Results: Our results demonstrated either free 17β-estradiol (E2) or membrane-impermeable bovine serum albumin-conjugated E2 (E2-BSA) could modulate human apoM gene expression via the estrogen receptor alpha (ER-α) pathway in the HepG2 cells. Moreover, experiments with the luciferase activity analysis of truncated apoM promoters could demonstrate that a regulatory region (from-1580 to −1575 bp (−GGTCA-)) upstream of the transcriptional start site of apoM gene was essential for the basal transcriptional activity that regulated by the ER-α. With the applications of an electrophoresis mobility shift assay and a chromatin immunoprecipitation assay, we could successfully identify a specific ER-α binding element in the apoM promoter region. Conculsion: In summary, the present study indicates that 17β-estradiol induced up-regulation of apoM in HepG2 cells is through an ER-α-dependent pathway involving ER-α binding element in the promoter of the apoM gene.
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| 43. |
- Wu, X. C., et al.
(författare)
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CPSDv0: a forest stand structure database for plantation forests in China
- 2023
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Ingår i: Big Earth Data. - : Informa UK Limited. - 2096-4471 .- 2574-5417. ; 7:1, s. 212-230
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Tidskriftsartikel (refereegranskat)abstract
- Forest stand structure is not only a crucial factor for regulating forest functioning but also an important indicator for sustainable forest management and ecosystem services. Although there exists a few national/global structure databases for natural forests, a country-wide synthetic structure database for plantation forests over China, the world's largest player in plantation forests, has not been achieved. In this study, we built a country-wide synthetic stand structure database by surveying more than 600 peer-reviewed literature. The database covers tree species, mean stand age, mean tree height, stand density, canopy coverage, diameter at breast height, as well as the associated ancillary in-situ topographical and soil properties. A total of 594 published studies concerning diverse forest stand structure parameters were compiled for 46 tree species. This first synthesis for stand structure of plantation forests over China supports studies on the evolution/ health of plantation forests in response to rapid climate change and intensified disturbances, and benefits country-wide sustainable forest management, future afforestation or reforestation planning. Potential users include those studying forest community dynamics, regional tree growth, ecosystem stability, and health, as well as those working with conservation and sustainable management.
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| 44. |
- Xie, Jiaying, et al.
(författare)
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STING activation in TET2-mutated hematopoietic stem/progenitor cells contributes to the increased self-renewal and neoplastic transformation
- 2023
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Ingår i: Leukemia. - : Springer Nature. - 0887-6924 .- 1476-5551. ; 37:12, s. 2457-2467
-
Tidskriftsartikel (refereegranskat)abstract
- Somatic loss-of-function mutations of the dioxygenase Ten-eleven translocation-2 (TET2) occur frequently in individuals with clonal hematopoiesis (CH) and acute myeloid leukemia (AML). These common hematopoietic disorders can be recapitulated in mouse models. However, the underlying mechanisms by which the deficiency in TET2 promotes these disorders remain unclear. Here we show that the cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-stimulator of interferon genes (STING) pathway is activated to mediate the effect of TET2 deficiency in dysregulated hematopoiesis in mouse models. DNA damage arising in Tet2-deficient hematopoietic stem/progenitor cells (HSPCs) leads to activation of the cGAS-STING pathway which in turn promotes the enhanced self-renewal and development of CH. Notably, both pharmacological inhibition and genetic deletion of STING suppresses Tet2 mutation-induced aberrant hematopoiesis. In patient-derived xenograft (PDX) models, STING inhibition specifically attenuates the proliferation of leukemia cells from TET2-mutated individuals. These observations suggest that the development of CH associated with TET2 mutations is powered through chronic inflammation dependent on the activated cGAS-STING pathway and that STING may represent a potential target for intervention of relevant hematopoietic diseases.
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| 45. |
- Ximing, Yue, et al.
(författare)
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Explaining Incomes and Inequality in China
- 2020
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Ingår i: Research on China’s Income Distribution and Labor Market (Vol.2, Ch.9). - Beijing, P.R. China : 9787516743188. - 9787516743188 ; , s. 205-232
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Bokkapitel (refereegranskat)
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| 46. |
- Xing, Xu, et al.
(författare)
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Double bismuth-based Bi2S3/Bi2MoO6 S-scheme heterojunction for ultrafast photocatalytic removal of Cr(VI)
- 2024
-
Ingår i: Journal of Environmental Chemical Engineering. - 2213-3437. ; 12:2
-
Tidskriftsartikel (refereegranskat)abstract
- The mild, fast and green removal of hexavalent chromium (Cr(VI)) from wastewater has already attracted extensive attention due to the severe acute toxicity and carcinogenicity of Cr(VI). At present work, Bi2S3/Bi2MoO6 S-scheme heterojunctions were constructed by facile solvothermal assembly and in situ anion exchange methods for visible light-driven efficient photocatalytic removal of Cr(VI). The structure-activity relationship, photoelectrochemical properties, and density functional theory (DFT) calculations revealed that the controllable construction of the heterostructure significantly expanded the light response range and remarkably enhanced the light absorption capacity. In particular, the unique charge transfer mechanism of this S-scheme heterojunction is conducive to promoting efficient separation of photogenerated charges and thus enhancing the photocatalytic performance. The results show that the total efficiency of Cr(VI) removal by the developed Bi2S3/Bi2MoO6 heterojunction under visible light irradiation is 98.5% within 6 min, with a k value of 0.466 min−1. This work provides a new route with enormous promise to construct bismuth-based S-scheme heterojunction photocatalysts for clean and efficient environmental remediation.
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| 47. |
- Yang, Hanmin, 1992-, et al.
(författare)
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Distributed electrified heating for efficient hydrogen production
- 2024
-
Ingår i: Nature Communications. - : Nature Research. - 2041-1723. ; 15:1
-
Tidskriftsartikel (refereegranskat)abstract
- This study introduces a distributed electrified heating approach that is able to innovate chemical engineering involving endothermic reactions. It enables rapid and uniform heating of gaseous reactants, facilitating efficient conversion and high product selectivity at specific equilibrium. Demonstrated in catalyst-free CH4 pyrolysis, this approach achieves stable production of H2 (530 g h−1 L reactor−1) and carbon nanotube/fibers through 100% conversion of high-throughput CH4 at 1150 °C, surpassing the results obtained from many complex metal catalysts and high-temperature technologies. Additionally, in catalytic CH4 dry reforming, the distributed electrified heating using metallic monolith with unmodified Ni/MgO catalyst washcoat showcased excellent CH4 and CO2 conversion rates, and syngas production capacity. This innovative heating approach eliminates the need for elongated reactor tubes and external furnaces, promising an energy-concentrated and ultra-compact reactor design significantly smaller than traditional industrial systems, marking a significant advance towards more sustainable and efficient chemical engineering society.
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| 48. |
- Yang, Hanmin, 1992-, et al.
(författare)
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Distributed electrified heating for efficient hydrogen production
- 2024
-
Ingår i: Nature Communications. - : Nature Research. - 2041-1723. ; 15
-
Tidskriftsartikel (refereegranskat)abstract
- This study introduces a distributed electrified heating approach that is able to innovate chemical engineering involving endothermic reactions. It enables rapid and uniform heating of gaseous reactants, facilitating efficient conversion and high product selectivity at specific equilibrium. Demonstrated in catalyst-free CH4 pyrolysis, this approach achieves stable production of H2 (530 g h−1 L reactor−1) and carbon nanotube/fibers through 100% conversion of high-throughput CH4 at 1150 °C, surpassing the results obtained from many complex metal catalysts and high-temperature technologies. Additionally, in catalytic CH4 dry reforming, the distributed electrified heating using metallic monolith with unmodified Ni/MgO catalyst washcoat showcased excellent CH4 and CO2 conversion rates, and syngas production capacity. This innovative heating approach eliminates the need for elongated reactor tubes and external furnaces, promising an energy-concentrated and ultra-compact reactor design significantly smaller than traditional industrial systems, marking a significant advance towards more sustainable and efficient chemical engineering society.
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| 49. |
- Yao, S. T., et al.
(författare)
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Waves in Kinetic-Scale Magnetic Dips : MMS Observations in the Magnetosheath
- 2019
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Ingår i: Geophysical Research Letters. - : AMER GEOPHYSICAL UNION. - 0094-8276 .- 1944-8007. ; 46:2, s. 523-533
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Tidskriftsartikel (refereegranskat)abstract
- Kinetic scale magnetic dips (KSMDs), with a significant depression in magnetic field strength, and scale length close to and less than one proton gyroradius, were reported in the turbulent plasmas both in recent observation and numerical simulation studies. These KSMDs likely play important roles in energy conversion and dissipation. In this study, we present observations of the KSMDs that are labeled whistler mode waves, electrostatic solitary waves, and electron cyclotron waves in the magnetosheath. The observations suggest that electron temperature anisotropy or beams within KSMD structures provide free energy to generate these waves. In addition, the occurrence rates of the waves are higher in the center of the magnetic dips than at their edges, implying that the KSMDs might be the origin of various kinds of waves. We suggest that the KSMDs could provide favorable conditions for the generation of waves and transfer energy to the waves in turbulent magnetosheath plasmas. Plain Language Summary The Earth's magnetosheath is a turbulent plasma environment where energy conversion, particle acceleration, and mass and momentum transport take place. Many of these key processes involve kinetic-scale physics. However, in-depth studies from previous missions are limited by their lower spacecraft data resolution. The recent Magnetospheric Multiscale (MMS) mission provides us with a large amount of high-temporal cadence data for studying kinetic-scale physics in the magnetosheath. In this study, we report whistler mode waves, electrostatic solitary waves and electron cyclotron waves within kinetic-scale magnetic dips (KSMDs) that can be generated in the turbulent magnetosheath. These waves could be excited by electron temperature anisotropy or beams. As is well known, plasma waves are important processes in converting energy, accelerating and scattering electrons and ions, and modifying the distributions of charged particles. If plasma instabilities develop within the KSMDs, the resulting waves could absorb free energy from plasma particles and may propagate out of the KSMDs. Thus, our discoveries could significantly advance the understanding of energy conversion and dissipation for kinetic-scale turbulence. This study provides a new reference not only for observations in space physics but also for related basic plasma theories and numerical simulations.
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| 50. |
- Yue, Lei, et al.
(författare)
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Microwave annealing as a low thermal budget technique for ZnO thin-film transistors fabricated using atomic layer deposition
- 2017
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Ingår i: IEEE Electron Device Letters. - 0741-3106 .- 1558-0563. ; 38, s. 1390-1393
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Tidskriftsartikel (refereegranskat)abstract
- Microwave annealing (MWA) and furnace annealing are compared for their low thermal budget capability to improve the characteristics of ZnO-based thin-film transistors (TFTs). Both the ZnO channel and the Al2O3 gate dielectric are fabricated using atomic layer deposition. Using Si-wafer-susceptor assisted MWA with a substantial reduction of both annealing temperature and duration, significant improvements of the characteristics of the ZnO TFTs can be attained. A multi-step MWA process is found to further improve the characteristics of the TFTs. For the same microwave power and total duration, the field-effect mobility of the multi-step MWA TFT is 42% greater than that of the one-step MWA TFT with a similar sub-threshold swing. The multi-step MWA process can serve the purpose at temperatures as low as 220 degrees C.
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