| 1. |
- Acharya, B. S., et al.
(författare)
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Introducing the CTA concept
- 2013
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Ingår i: Astroparticle physics. - : Elsevier BV. - 0927-6505 .- 1873-2852. ; 43, s. 3-18
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The Cherenkov Telescope Array (CTA) is a new observatory for very high-energy (VHE) gamma rays. CTA has ambitions science goals, for which it is necessary to achieve full-sky coverage, to improve the sensitivity by about an order of magnitude, to span about four decades of energy, from a few tens of GeV to above 100 TeV with enhanced angular and energy resolutions over existing VHE gamma-ray observatories. An international collaboration has formed with more than 1000 members from 27 countries in Europe, Asia, Africa and North and South America. In 2010 the CTA Consortium completed a Design Study and started a three-year Preparatory Phase which leads to production readiness of CTA in 2014. In this paper we introduce the science goals and the concept of CTA, and provide an overview of the project. (C) 2013 Elsevier B.V. All rights reserved.
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| 2. |
- Landegren, N, et al.
(författare)
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AIREing out autoimmunity
- 2015
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Ingår i: SCIENCE TRANSLATIONAL MEDICINE. - 1946-6234. ; 7:292
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 3. |
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| 4. |
- Amada, K., et al.
(författare)
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Discovery of SiO Masers in the "Water Fountain" Source IRAS 16552-3050
- 2022
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Ingår i: Astronomical Journal. - : American Astronomical Society. - 1538-3881 .- 0004-6256. ; 163:2
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Tidskriftsartikel (refereegranskat)abstract
- In this paper, we report new detections of SiO v = 1 and v = 2 J = 1 -> 0 masers in the "water fountain" source IRAS 16552-3050, which was observed with the Nobeyama 45 m telescope during 2021 March-April. Water fountains are evolved stars whose H2O maser spectra trace high-velocity outflows of >100 km s(-1). This is the second known case of SiO masers in a water fountain, after their prototypical source, W 43A. These SiO masers should shed light on the evolutionary status of this category of evolved stars, which are likely to be at the end of the asymptotic giant branch phase, when the star exhibits the most copious stellar mass loss, followed by development of the complicated morphologies of planetary nebulae. The origin of a large (up to 25 km s(-1)) velocity offset of the SiO masers with respect to the systemic velocity derived from the spectrum of CO J = 2 -> 1 line is discussed here.
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| 5. |
- Amada, Kei, et al.
(författare)
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Discovery of SiO masers in the Water Fountain source, IRAS 16552-3050
- 2022
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Ingår i: Proceedings of the International Astronomical Union. - 1743-9213 .- 1743-9221. ; 18, s. 359-361
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Konferensbidrag (refereegranskat)abstract
- We report new detections of SiO ν = 1 and ν = 2 J = 1 → 0 masers in the water fountain source IRAS 16552-3050, which was observed with the Nobeyama 45 m telescope from March 2021 to April 2023. Water fountains are evolved stars whose H2O maser spectra trace high-velocity outflows of >100 Km s-. This is the second known case of SiO masers in a water fountain, after their prototypical source, W 43A. The line-of-sight velocity of the SiO masers are blue-shifted by ∼25 km s-1 from the systemic velocity. This velocity offset imply that the SiO masers are associated with nozzle structure formed by a jet penetrating the circumstellar envelope, and that new gas blobs of the jet erupted recently. Thus, the SiO masers imply this star to be in a new evolutionary stage.
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| 6. |
- Bösl, Korbinian, et al.
(författare)
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Common Nodes of Virus-Host Interaction Revealed Through an Integrated Network Analysis
- 2019
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Ingår i: Frontiers in Immunology. - : FRONTIERS MEDIA SA. - 1664-3224. ; 10
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Tidskriftsartikel (refereegranskat)abstract
- Viruses are one of the major causes of acute and chronic infectious diseases and thus a major contributor to the global burden of disease. Several studies have shown how viruses have evolved to hijack basic cellular pathways and evade innate immune response by modulating key host factors and signaling pathways. A collective view of these multiple studies could advance our understanding of virus-host interactions and provide new therapeutic perspectives for the treatment of viral diseases. Here, we performed an integrative meta-analysis to elucidate the 17 different host-virus interactomes. Network and bioinformatics analyses showed how viruses with small genomes efficiently achieve the maximal effect by targeting multifunctional and highly connected host proteins with a high occurrence of disordered regions. We also identified the core cellular process subnetworks that are targeted by all the viruses. Integration with functional RNA interference (RNAi) datasets showed that a large proportion of the targets are required for viral replication. Furthermore, we performed an interactome-informed drug re-purposing screen and identified novel activities for broad-spectrum antiviral agents against hepatitis C virus and human metapneumovirus. Altogether, these orthogonal datasets could serve as a platform for hypothesis generation and follow-up studies to broaden our understanding of the viral evasion landscape.
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| 7. |
- Dong, H., et al.
(författare)
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Generalized Mueller matrix method for polarization mode dispersion measurement in a system with polarization-dependent loss or gain
- 2006
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Ingår i: Optics Express. - : Optical Society of America. - 1094-4087. ; 14:12, s. 5067-5072
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Tidskriftsartikel (refereegranskat)abstract
- A generalized Mueller matrix method (GMMM) is proposed to measure the polarization mode dispersion (PMD) in an optical fiber system with polarization-dependent loss or gain (PDL/G). This algorithm is based on the polar decomposition of a 4×4 matrix which corresponds to a Lorentz transformation. Compared to the generalized Poincaré sphere method, the GMMM can measure PMD accurately with a relatively larger frequency step, and the obtained PMD data has very low noise level.
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| 8. |
- Dong, H., et al.
(författare)
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Quasi-monochromatic fiber depolarizer and its application to polarization-dependent loss measurement
- 2006
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Ingår i: Optics Letters. - : Optical Society of America. - 0146-9592 .- 1539-4794. ; 31:7, s. 876-878
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Tidskriftsartikel (refereegranskat)abstract
- We theoretically derive the relationship between the degrees of polarization (DOPs) of input and output for an optical component with polarization-dependent loss (PDL) and birefringence. Based on the theoretical result, we propose a novel depolarizer for quasi-monochromatic light that can depolarize a fully polarized light with a 50 MHz50 MHz linewidth to less than 0.2% in the DOP. The depolarized light is then used to measure PDL in a single-mode optical fiber link. To the best of our knowledge, our new PDL measurement method is significantly faster than all known methods. Experimental results show excellent agreement with other methods.
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| 9. |
- Feng, Z., et al.
(författare)
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Power efficient optical OFDM transmission with phase modulation and direct detection
- 2016
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Ingår i: 2016 21st OptoElectronics and Communications Conference, OECC 2016 - Held Jointly with 2016 International Conference on Photonics in Switching, PS 2016. - : IEEE conference proceedings. - 9784885523052
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Konferensbidrag (refereegranskat)abstract
- Optical OFDM transmission with phase modulation and direct detection (PMDD) is verified by theoretical derivation and simulation. 26.12-Gb/s PMDD 16QAM-OFDM achieves comparable performance to single sideband IMDD 16QAM-OFDM with half of the optical modulation index.
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| 10. |
- Feng, Zhenhua, et al.
(författare)
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SNR equalized optical direct-detected OFDM transmission with CAZAC equalization
- 2015
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Ingår i: CLEO. - : Optica Publishing Group.
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Konferensbidrag (refereegranskat)abstract
- 50Km SSMF optical direct-detected OFDM transmission with Constant Amplitude Zero Auto Correlation Sequence (CAZAC) equalization is experimentally demonstrated with over 15dB power budget. 2.5dB enhancement in sensitivity has been achieved simultaneously with 3dB PAPR suppression.
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| 11. |
- Imai, H., et al.
(författare)
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Water and silicon-monoxide masers monitored towards the water fountain sources
- 2021
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Ingår i: Proceedings of the International Astronomical Union. - 1743-9213 .- 1743-9221. ; 17, s. 91-93
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Konferensbidrag (refereegranskat)abstract
- We have investigated the evolution of 12 water fountain sources in real time in the accompanying H2O 2o and SiO masers through our FLASHING (Finest Legacy Acquisitions of SiO-/ H2O 2o-maser Ignitions by Nobeyama Generation) project. It has been confirmed that these masers are excellent probes of new jet blob ejections, acceleration of the material supplied from the parental circumstellar envelope and entrained by the stellar jets yielding its deceleration. Possible periodic variations of the maser emission, reflecting properties of the central dying stars or binary systems, will be further investigated.
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| 12. |
- Imai, Hiroshi, et al.
(författare)
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Water Fountain Sources Monitored in FLASHING
- 2022
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Ingår i: Proceedings of the International Astronomical Union. - 1743-9213 .- 1743-9221. ; 18, s. 333-337
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Konferensbidrag (refereegranskat)abstract
- We have investigated the spectral evolutions of H2O and SiO masers associated with 12 water fountain sources in our FLASHING (Finest Legacy Acquisitions of SiO-/H2O-maser Ignitions by Nobeyama Generation) project. Our monitoring observations have been conducted using the Nobeyama 45 m telescope every 2 weeks-2 months since 2018 December except during summer seasons. We have found new extremely high velocity H2O maser components, breaking the records of jet speeds in this type of sources. Systematic line-of-sight velocity drifts of the H2O maser spectral peaks have also been found, indicating acceleration of the entrained material hosting the masers around the jet. Moreover, by comparing with previous spectral data, we can find decadal growths/decays of H2O maser emission. Possible periodic variations of the maser spectra are further being inspected in order to explore the periodicity of the central stellar system (a pulsating star or a binary). Thus we expect to see the real-time evolution/devolutions of the water fountains over decades.
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| 13. |
- Landegren, Nils, et al.
(författare)
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Transglutaminase 4 as a prostate autoantigen in male subfertility
- 2015
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Ingår i: Science Translational Medicine. - : American Association for the Advancement of Science. - 1946-6234 .- 1946-6242. ; 7:292
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Tidskriftsartikel (refereegranskat)abstract
- Autoimmune polyendocrine syndrome type 1 (APS1), a monogenic disorder caused by AIRE gene mutations, features multiple autoimmune disease components. Infertility is common in both males and females with APS1. Although female infertility can be explained by autoimmune ovarian failure, the mechanisms underlying male infertility have remained poorly understood. We performed a proteome-wide autoantibody screen in APS1 patient sera to assess the autoimmune response against the male reproductive organs. By screening human protein arrays with male and female patient sera and by selecting for gender-imbalanced autoantibody signals, we identified transglutaminase 4 (TGM4) as a male-specific autoantigen. Notably, TGM4 is a prostatic secretory molecule with critical role in male reproduction. TGM4 autoantibodies were detected in most of the adult male APS1 patients but were absent in all the young males. Consecutive serum samples further revealed that TGM4 autoantibodies first presented during pubertal age and subsequent to prostate maturation. We assessed the animal model for APS1, the Aire-deficient mouse, and found spontaneous development of TGM4 autoantibodies specifically in males. Aire-deficient mice failed to present TGM4 in the thymus, consistent with a defect in central tolerance for TGM4. In the mouse, we further link TGM4 immunity with a destructive prostatitis and compromised secretion of TGM4. Collectively, our findings in APS1 patients and Aire-deficient mice reveal prostate autoimmunity as a major manifestation of APS1 with potential role in male subfertility.
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| 14. |
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| 15. |
- Shum, Anthony K., et al.
(författare)
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BPIFB1 Is a Lung-Specific Autoantigen Associated with Interstitial Lung Disease
- 2013
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Ingår i: Science Translational Medicine. - : American Association for the Advancement of Science (AAAS). - 1946-6234 .- 1946-6242. ; 5:206, s. 206ra139-
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Tidskriftsartikel (refereegranskat)abstract
- Interstitial lung disease (ILD) is a complex and heterogeneous disorder that is often associated with autoimmune syndromes. Despite the connection between ILD and autoimmunity, it remains unclear whether ILD can develop from an autoimmune response that specifically targets the lung parenchyma. We examined a severe form of autoimmune disease, autoimmune polyglandular syndrome type 1 (APS1), and established a strong link between an autoimmune response to the lung-specific protein BPIFB1 (bactericidal/permeability-increasing fold-containing B1) and clinical ILD. Screening of a large cohort of APS1 patients revealed autoantibodies to BPIFB1 in 9.6% of APS1 subjects overall and in 100% of APS1 subjects with ILD. Further investigation of ILD outside the APS1 disorder revealed BPIFB1 autoantibodies present in 14.6% of patients with connective tissue disease-associated ILD and in 12.0% of patients with idiopathic ILD. The animal model for APS1, Aire(-/-) mice, harbors autoantibodies to a similar lung antigen (BPIFB9); these autoantibodies are a marker for ILD. We found that a defect in thymic tolerance was responsible for the production of BPIFB9 autoantibodies and the development of ILD. We also found that immunoreactivity targeting BPIFB1 independent of a defect in Aire also led to ILD, consistent with our discovery of BPIFB1 autoantibodies in non-APS1 patients. Overall, our results demonstrate that autoimmunity targeting the lung-specific antigen BPIFB1 may contribute to the pathogenesis of ILD in patients with APS1 and in subsets of patients with non-APS1 ILD, demonstrating the role of lung-specific autoimmunity in the genesis of ILD.
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| 16. |
- Yan, M., et al.
(författare)
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Design of air-guiding honeycomb photonic bandgap fiber
- 2005
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Ingår i: Optics Letters. - : Optical Society of America. - 0146-9592 .- 1539-4794. ; 30:5, s. 465-467
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Tidskriftsartikel (refereegranskat)abstract
- We introduce a design procedure for hollow-core photonic bandgap (PBG) fiber with a cladding made of air–silica honeycomb photonic crystal (PC). It is found that air-guiding can be realized in both fundamental and secondary PBG regions of the cladding PC. Dispersion and radiation loss of the fundamental mode for two types of fiber structure are theoretically calculated. The fibers show promising waveguiding ability.
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| 17. |
- Zhang, L., et al.
(författare)
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Low-cost in-band OSNR monitoring based on coherent hybrid in CO-OFDM system
- 2015
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Ingår i: CLEO: Science and Innovations, CLEO-SI 2015.
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Konferensbidrag (refereegranskat)abstract
- We proposed and demonstrated a cost-effective in-band optical signal to noise ratio (OSNR) monitoring technique based on coherent hybrid in 20Gb/s CO-OFDM system. Less than 0.5dB monitoring error is achieved with 400MHz balanced photodetector (PD).
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