| 1. |
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
|
|
| 6. |
|
|
| 7. |
|
|
| 8. |
|
|
| 9. |
|
|
| 10. |
|
|
| 11. |
|
|
| 12. |
|
|
| 13. |
|
|
| 14. |
|
|
| 15. |
|
|
| 16. |
- Bretillon, L, et al.
(författare)
-
Plasma levels of 24S-hydroxycholesterol in patients with neurological diseases
- 2000
-
Ingår i: Neuroscience Letters. - 0304-3940. ; 293:2, s. 87-90
-
Tidskriftsartikel (refereegranskat)abstract
- The brain is the exclusive or almost exclusive site of formation of 24S-hydroxycholesterol and we have shown that the circulating level of 24S-hydroxycholesterol is dependent upon the relation between cerebral production and hepatic clearance. In the present work we determined plasma levels of 24S-hydroxycholesterol in patients with various neurological diseases. Eleven subjects with brain death occurring 6-10 h before collection of the plasma samples had markedly reduced circulating levels of 24S-hydroxycholesterol (-43%, P<0.001). Patients with advanced Alzheimer's disease and cerebral inflammatory diseases had slightly lower levels of 24S-hydroxycholesterol in plasma when compared to matched controls. Patients with acute ischemic stroke, multiple sclerosis and primary brain tumors had levels not significantly different from those of controls. The conditions leading to reduced plasma levels of 24S-hydroxycholesterol had no significant effect on plasma levels of another side-chain oxidized oxysterol, 27-hydroxycholesterol. Except for conditions characterized by very marked destruction of the central nervous system, different severe neurological diseases seem to have relatively small effects on the flux of 24S-hydroxycholesterol from the brain.
|
|
| 17. |
- Cruz, MH, et al.
(författare)
-
The stemness phenotype model
- 2012
-
Ingår i: ISRN oncology. - : Hindawi Limited. - 2090-567X. ; 2012, s. 392647-
-
Tidskriftsartikel (refereegranskat)abstract
- The identification of a fraction of cancer stem cells (CSCs) associated with resistance to chemotherapy in most solid tumors leads to the dogma that eliminating this fraction will cure cancer. Experimental data has challenged this simplistic and optimistic model. Opposite to the classical cancer stem cell model, we introduced the stemness phenotype model (SPM), which proposed that all glioma cells possess stem cell properties and that the stemness is modulated by the microenvironment. A key prediction of the SPM is that to cure gliomas all gliomas cells (CSCs and non-CSCs) should be eliminated at once. Other theories closely resembling the SPM and its predictions have recently been proposed, suggesting that the SPM may be a useful model for other type of tumors. Here, we review data from other tumors that strongly support the concepts of the SPM applied to gliomas. We include data related to: (1) the presence of a rare but constant fraction of CSCs in established cancer cell lines, (2) the clonal origin of cancer, (3) the symmetrical division, (4) the ability of “non-CSCs” to generate “CSCs,” and (5) the effect of the microenvironment on cancer stemness. The aforenamed issues that decisively supported the SPM proposed for gliomas can also be applied to breast, lung, prostate cancer, and melanoma and perhaps other tumors in general. If the glioma SPM is correct and can be extrapolated to other types of cancer, it will have profound implications in the development of novel modalities for cancer treatment.
|
|
| 18. |
|
|
| 19. |
|
|
| 20. |
|
|
| 21. |
- Delwar, ZM, et al.
(författare)
-
Menadione : sodium orthovanadate combination eliminates and inhibits migration of detached cancer cells
- 2012
-
Ingår i: ISRN pharmacology. - : Hindawi Limited. - 2090-5173. ; 2012, s. 307102-
-
Tidskriftsartikel (refereegranskat)abstract
- Exposure of cancer cells to anticancer agents in cultures induces detachment of cells that are usually considered dead. These drug-induced detached cells (D-IDCs) may represent a clinical problem for chemotherapy since they may survive anoikis, enter the circulation, invade other tissues and resume proliferation, creating a metastasis, especially in tissues where the bioavailability of anticancer agents is not enough to eliminate all cancer cells. In this study we evaluated the antiproliferative effect of menadione : sodium orthovanadate (M : SO) combination on A549 lung cancer cells as well as the ability of M : SO to induce cell detachment. In addition, we followed the fate and chemosensitivity of M : SO-induced detached cells. Using transwell chambers, we found that a fraction of the M : SO-induced detached cells were viable and, furthermore, were able to migrate, re-attach, and resume proliferation when re-incubated in drug-free media. The total elimination of A549 detachment-resistant cells and M : SO-induced detached cells were successfully eliminated by equivalent M : SO concentration (17.5 μM : 17.5 μM). Thus, M : SO prevented cell migration. Similar results were obtained on DBTRG.05MG human glioma cells. Our data guarantee further studies to evaluate the in vivo occurrence of D-IDCs, their implications for invasiveness and metastasis and their sensitivity to anticancer drugs.
|
|
| 22. |
|
|
| 23. |
|
|
| 24. |
- Forsström, Stefan, 1984-, et al.
(författare)
-
Specialanpassade kurser för yrkesverksamma ingenjörer : Erfarenheter och upplevelser
- 2023
-
Ingår i: Bidrag från den 9:e utvecklingskonferensen för Sveriges ingenjörsutbildningar. - : Mälardalens universitet. - 9789174856200 ; , s. 348-353
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- I dagens samhälle blir det allt viktigare att fortbilda sig under hela sitt yrkesverksamma liv. För att möta efterfrågan på det livslånga lärandet har Mittuniversitetet utvecklat och genomfört ett antal kurser som riktar sig mot yrkesverksamma ingenjörer. Detta arbete presenterar våra erfarenheter av att ge dessa kurser, med en tyngdpunkt på studenternas upplevelser. Syftet med detta är att bygga upp en vetenskaplig bas för vad vi gör som är bra, men även vad som kan förbättras och förändras. Målsättningen är att göra dessa specialanpassade kurser riktade mot yrkesverksamma ingenjörer så givande och flexibla som möjligt. Våra initiala resultat visar bland annat att studenternas negativa upplevelser ofta var kopplade till antagningsförfarandet och det praktiska genomförandet av kurserna. Man hade svårigheter med att hitta hur man skulle registrera sig på kursen och att tidsramen för registrering kunde vara ett problem. Läroplattformen uppfattades som svår att överblicka och det förekom även viss otydlighet gällande var undervisningen skulle äga rum. Den positiva responsen i utvärderingarna gällde främst det faktiska kursinnehållet, då man ansåg att uppgifter och kursmaterial var givande. Vidare uppskattades kursupplägget, att man kunde kombinera studierna med arbete. Framledes kommer vi att fortsätta med dessa utvärderingar i takt med att kurserna ges, och därefter anpassa vårt mottagande och kommunikationen med studenterna. Även kursupplägget ses över kontinuerligt via den återkoppling vi mottar.
|
|
| 25. |
|
|
| 26. |
- Lutjohann, D, et al.
(författare)
-
Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation
- 1996
-
Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424. ; 93:18, s. 9799-9804
-
Tidskriftsartikel (refereegranskat)abstract
- We have investigated whether side chain-hydroxylated cholesterol species are important for elimination of cholesterol from the brain. Plasma concentrations of 24-hydroxycholesterol (24-OH-Chol) in the internal jugular vein and the brachial artery in healthy volunteers were consistent with a net flux of this steroid from the brain into the circulation, corresponding to elimination of approximately 4 mg cholesterol during a 24-h period in adults. Results of experiments with rats exposed to 18O2 were also consistent with a flux of 24-OH-Chol from the brain into the circulation. No other oxysterol measured showed a similar behavior as 24-OH-Chol. These results and the finding that the concentration of 24-OH-Chol was 30- to 1500-fold higher in the brain than in any other organ except the adrenals indicate that the major part of 24-OH-Chol present in the circulation originates from the brain. Both the 24-OH-Chol present in the brain and in the circulation were the 24S-stereoisomer. In contrast to other oxysterols, levels of plasma 24-OH-Chol were found to be markedly dependent upon age. The ratio between 24-OH-Chol and cholesterol in plasma was approximately 5 times higher during the first decade of life than during the sixth decade. There was a high correlation between levels of 24-OH-Chol in plasma and cerebrospinal fluid. It is suggested that the flux of 24-OH-Chol from the brain is important for cholesterol homeostasis in this organ.
|
|
| 27. |
- Ma, C, et al.
(författare)
-
Translational gap in glioma research
- 2014
-
Ingår i: Anti-cancer agents in medicinal chemistry. - : Bentham Science Publishers Ltd.. - 1875-5992 .- 1871-5206. ; 14:8, s. 1110-1120
-
Tidskriftsartikel (refereegranskat)
|
|
| 28. |
- Mahillo-Fernandez, I, et al.
(författare)
-
Surgery and risk of sporadic Creutzfeldt-Jakob disease in Denmark and Sweden: registry-based case-control studies
- 2008
-
Ingår i: Neuroepidemiology. - : S. Karger AG. - 1423-0208 .- 0251-5350. ; 31:4, s. 229-240
-
Tidskriftsartikel (refereegranskat)abstract
- <i>Background:</i> Epidemiologic evidence of surgical transmission of sporadic Creutzfeldt-Jakob disease (sCJD) remains controversial. <i>Methods:</i> From Danish and Swedish registries we selected 167 definite and probable sCJD cases (with onset between 1987 and 2003) and 3,059 controls (835 age-, sex-, and residence-matched, and 2,224 unmatched). Independent of case/control status, surgical histories were obtained from National Hospital Discharge Registries. Surgical procedures were categorized by body system group and lag time to onset of sCJD. Exposure frequencies were compared using logistic regression. <i>Results:</i> A history of any major surgery, conducted ≧20 years before sCJD onset, was more common in cases than both matched (OR = 2.44, 95% CI = 1.46–4.07) and unmatched controls (OR = 2.25, 95% CI = 1.48–3.44). This observation was corroborated by a linear increase in risk per surgical discharge (OR = 1.57, 95% CI = 1.13–2.18; OR = 1.50, 95% CI = 1.18–1.91). Surgery of various body systems, including peripheral vessels, digestive system and spleen, and female genital organs, was significantly associated with increased sCJD risk. <i>Conclusions:</i> A variety of major surgical procedures constitute a risk factor for sCJD following an incubation period of many years. A considerable number of sCJD cases may originate from health care-related accidental transmission.
|
|
| 29. |
|
|
| 30. |
|
|
| 31. |
|
|
| 32. |
|
|
| 33. |
|
|
| 34. |
|
|
| 35. |
|
|
| 36. |
|
|
| 37. |
|
|
| 38. |
|
|
| 39. |
|
|
| 40. |
|
|
| 41. |
|
|
