| 1. |
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| 2. |
- Abdo, A. A., et al.
(författare)
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Multi-wavelength observations of the flaring gamma-ray blazar 3C 66A in 2008 October
- 2011
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 726:1, s. 43-
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Tidskriftsartikel (refereegranskat)abstract
- The BL Lacertae object 3C 66A was detected in a flaring state by the Fermi Large Area Telescope (LAT) and VERITAS in 2008 October. In addition to these gamma-ray observations, F-GAMMA, GASP-WEBT, PAIRITEL, MDM, ATOM, Swift, and Chandra provided radio to X-ray coverage. The available light curves show variability and, in particular, correlated flares are observed in the optical and Fermi-LAT gamma-ray band. The resulting spectral energy distribution can be well fitted using standard leptonic models with and without an external radiation field for inverse Compton scattering. It is found, however, that only the model with an external radiation field can accommodate the intra-night variability observed at optical wavelengths.
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| 3. |
- Dornelas, M., et al.
(författare)
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BioTIME: A database of biodiversity time series for the Anthropocene
- 2018
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Ingår i: Global Ecology and Biogeography. - : Wiley. - 1466-822X .- 1466-8238. ; 27:7, s. 760-786
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Tidskriftsartikel (refereegranskat)abstract
- Motivation: The BioTIME database contains raw data on species identities and abundances in ecological assemblages through time. These data enable users to calculate temporal trends in biodiversity within and amongst assemblages using a broad range of metrics. BioTIME is being developed as a community-led open-source database of biodiversity time series. Our goal is to accelerate and facilitate quantitative analysis of temporal patterns of biodiversity in the Anthropocene. Main types of variables included: The database contains 8,777,413 species abundance records, from assemblages consistently sampled for a minimum of 2 years, which need not necessarily be consecutive. In addition, the database contains metadata relating to sampling methodology and contextual information about each record. Spatial location and grain: BioTIME is a global database of 547,161 unique sampling locations spanning the marine, freshwater and terrestrial realms. Grain size varies across datasets from 0.0000000158 km(2) (158 cm(2)) to 100 km(2) (1,000,000,000,000 cm(2)). Time period and grainBio: TIME records span from 1874 to 2016. The minimal temporal grain across all datasets in BioTIME is a year. Major taxa and level of measurement: BioTIME includes data from 44,440 species across the plant and animal kingdoms, ranging from plants, plankton and terrestrial invertebrates to small and large vertebrates.
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| 4. |
- Ackermann, M., et al.
(författare)
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MULTI-WAVELENGTH OBSERVATIONS OF BLAZAR AO 0235+164 IN THE 2008-2009 FLARING STATE
- 2012
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Ingår i: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 751:2
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Tidskriftsartikel (refereegranskat)abstract
- The blazarAO 0235+164 (z=0.94) has been one of the most active objects observed by Fermi Large Area Telescope (LAT) since its launch in Summer 2008. In addition to the continuous coverage by Fermi, contemporaneous observations were carried out from the radio to gamma-ray bands between 2008 September and 2009 February. In this paper, we summarize the rich multi-wavelength data collected during the campaign (including F-GAMMA, GASP-WEBT, Kanata, OVRO, RXTE, SMARTS, Swift, and other instruments), examine the cross-correlation between the light curves measured in the different energy bands, and interpret the resulting spectral energy distributions in the context of well-known blazar emission models. We find that the gamma-ray activity is well correlated with a series of near-IR/optical flares, accompanied by an increase in the optical polarization degree. On the other hand, the X-ray light curve shows a distinct 20 day high state of unusually soft spectrum, which does not match the extrapolation of the optical/UV synchrotron spectrum. We tentatively interpret this feature as the bulk Compton emission by cold electrons contained in the jet, which requires an accretion disk corona with an effective covering factor of 19% at a distance of 100 R-g. We model the broadband spectra with a leptonic model with external radiation dominated by the infrared emission from the dusty torus.
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| 5. |
- Fernandez, J. L. Abelleira, et al.
(författare)
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A Large Hadron Electron Collider at CERN
- 2012
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Ingår i: Journal of Physics G. - : IOP Publishing. - 0954-3899 .- 1361-6471. ; 39:7
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Tidskriftsartikel (refereegranskat)
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| 6. |
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| 7. |
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| 8. |
- Ricci, M., et al.
(författare)
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The XXL Survey: XLIV. Sunyaev-Zel'dovich mapping of a low-mass cluster at z ∼1: A multi-wavelength approach
- 2020
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 642
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Tidskriftsartikel (refereegranskat)abstract
- High-mass clusters at low redshifts have been intensively studied at various wavelengths. However, while more distant objects at lower masses constitute the bulk population of future surveys, their physical state remain poorly explored to date. In this paper, we present resolved observations of the Sunyaev-Zel'dovich (SZ) effect, obtained with the NIKA2 camera, towards the cluster of galaxies XLSSC 102, a relatively low-mass system (M500 ∼ 2 × 1014 M·) at z = 0.97 detected from the XXL survey. We combine NIKA2 SZ data, XMM-Newton X-ray data, and Megacam optical data to explore, respectively, the spatial distribution of the gas electron pressure, the gas density, and the galaxies themselves. We find significant offsets between the X-ray peak, the SZ peak, the brightest cluster galaxy, and the peak of galaxy density. Additionally, the galaxy distribution and the gas present elongated morphologies. This is interpreted as the sign of a recent major merging event, which induced a local boost of the gas pressure towards the north of XLSSC 102 and stripped the gas out of the galaxy group. The NIKA2 data are also combined with XXL data to construct the thermodynamic profiles of XLSSC 102, obtaining relatively tight constraints up to about ∼r500, and revealing properties that are typical of disturbed systems. We also explore the impact of the cluster centre definition and the implication of local pressure substructure on the recovered profiles. Finally, we derive the global properties of XLSSC 102 and compare them to those of high-mass-and-low-redshift systems, finding no strong evidence for non-standard evolution. We also use scaling relations to obtain alternative mass estimates from our profiles. The variation between these different mass estimates reflects the difficulty to accurately measure the mass of low-mass clusters at z ∼ 1, especially with low signal-to-noise ratio data and for a disturbed system. However, it also highlights the strength of resolved SZ observations alone and in combination with survey-like X-ray data. This is promising for the study of high redshift clusters from the combination of eROSITA and high resolution SZ instruments and will complement the new generation of optical surveys from facilities such as LSST and Euclid.
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| 9. |
- Adam, R. M., et al.
(författare)
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The XXL Survey: LI. Pressure profile and Y SZ -M scaling relation in three low-mass galaxy clusters at z∼1 observed with NIKA2
- 2024
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Ingår i: Astronomy and Astrophysics. - 0004-6361 .- 1432-0746. ; 684
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Tidskriftsartikel (refereegranskat)abstract
- Context. The thermodynamical properties of the intracluster medium (ICM) are driven by scale-free gravitational collapse, but they also reflect the rich astrophysical processes at play in galaxy clusters. At low masses (∼1014M) and high redshift (z≳1), these properties remain poorly constrained, observationally speaking, due to the difficulty in obtaining resolved and sensitive data. Aims. We aim to investigate the inner structure of the ICM as seen through the Sunyaev-Zel’dovich (SZ) effect in this regime of mass and redshift. We focused on the thermal pressure profile and the scaling relation between SZ flux and mass, namely the YSZ-M scaling relation. Methods. The three galaxy clusters XLSSC 072 (z=1.002), XLSSC 100 (z=0.915), and XLSSC 102 (z=0.969), with M500∼2×1014M, were selected from the XXL X-ray survey and observed with the NIKA2 millimeter camera to image their SZ signal. XMM-Newton X-ray data were used as a complement to the NIKA2 data to derive masses based on the YX-M relation and the hydrostatic equilibrium. Results. The SZ images of the three clusters, along with the X-ray and optical data, indicate dynamical activity related to merging events. The pressure profile is consistent with that expected for morphologically disturbed systems, with a relatively flat core and a shallow outer slope. Despite significant disturbances in the ICM, the three high-redshift low-mass clusters follow the YSZ-M relation expected from standard evolution remarkably well. Conclusions. These results indicate that the dominant physics that drives cluster evolution is already in place by z∼1, at least for systems with masses above M500∼1014M.
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| 10. |
- Ritacco, A., et al.
(författare)
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NIKA 150 GHz polarization observations of the Crab nebula and its spectral energy distribution
- 2018
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 616
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Tidskriftsartikel (refereegranskat)abstract
- The Crab nebula is a supernova remnant exhibiting a highly polarized synchrotron radiation at radio and millimetre wavelengths. It is the brightest source in the microwave sky with an extension of 7 by 5 arcmin, and is commonly used as a standard candle for any experiment which aims to measure the polarization of the sky. Though its spectral energy distribution has been well characterized in total intensity, polarization data are still lacking at millimetre wavelengths. We report in this paper high resolution observations (18 00 FWHM) of the Crab nebula in total intensity and linear polarization at 150 GHz with the NIKA camera. NIKA, operated at the IRAM 30 m telescope from 2012 to 2015, is a camera made of Lumped Element Kinetic Inductance Detectors (LEKIDs) observing the sky at 150 and 260 GHz. From these observations we are able to reconstruct the spatial distribution of the polarization degree and angle of the Crab nebula, which is found to be compatible with previous observations at lower and higher frequencies. Averaging across the source and using other existing data sets we find that the Crab nebula polarization angle is consistent with being constant over a wide range of frequencies with a value of -87.7 degrees +/- 0.3 in Galactic coordinates. We also present the first estimation of the Crab nebula spectral energy distribution polarized flux in a wide frequency range: 30-353 GHz. Assuming a single power law emission model we find that the polarization spectral index beta(pol) = -0.347 +/- 0.026 is compatible with the intensity spectral index beta = -0.323 +/- 0.001.
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| 11. |
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| 12. |
- Sokolovsky, K. V., et al.
(författare)
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Two active states of the narrow-line gamma-ray-loud AGN GB 1310+487
- 2014
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 565
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Tidskriftsartikel (refereegranskat)abstract
- Context. Previously unremarkable, the extragalactic radio source GB 1310+487 showed gamma-ray flare on 2009 November 18, reaching a daily flux of similar to 10(-6) photons cm(-2) s(-1) at energies E > 100 MeV and became one of the brightest GeV sources for about two weeks. Its optical spectrum shows strong forbidden-line emission while lacking broad permitted lines, which is not typical for a blazar. Instead, the spectrum resembles those of narrow emission-line galaxies. Aims. We investigate changes in the object's radio-to-GeV spectral energy distribution (SED) during and after the prominent gamma-ray flare with the aim of determining the nature of the object and of constraining the origin of the variable high-energy emission. Methods. The data collected by the Fermi and AGILE satellites at gamma-ray energies; Swift at X-ray and ultraviolet (UV); the Kanata, NOT, and Keck telescopes at optical; OAGH and WISE at infrared (IR); and IRAM 30m, OVRO 40m, Effelsberg 100 m, RATAN-600, and VLBA at radio are analyzed together to trace the SED evolution on timescales of months. Results. The gamma-ray/ radio-loud narrow-line active galactic nucleus (AGN) is located at redshift z = 0.638. It shines through an unrelated foreground galaxy at z = 0.500. The AGN light is probably amplified by gravitational lensing. The AGN SED shows a two-humped structure typical of blazars and gamma-ray-loud narrow-line Seyfert 1 galaxies, with the high-energy (inverse-Compton) emission dominating by more than an order of magnitude over the low-energy (synchrotron) emission during gamma-ray flares. The difference between the two SED humps is smaller during the low-activity state. Fermi observations reveal a strong correlation between the gamma-ray flux and spectral index, with the hardest spectrum observed during the brightest gamma-ray state. The gamma-ray flares occurred before and during a slow rising trend in the radio, but no direct association between gamma-ray and radio flares could be established. Conclusions. If the gamma-ray flux is a mixture of synchrotron self-Compton and external Compton emission, the observed GeV spectral variability may result from varying relative contributions of these two emission components. This explanation fits the observed changes in the overall IR to gamma-ray SED.
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| 13. |
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| 14. |
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| 15. |
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| 16. |
- Ade, Peter, et al.
(författare)
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The Simons Observatory : science goals and forecasts
- 2019
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Ingår i: Journal of Cosmology and Astroparticle Physics. - : IOP Publishing. - 1475-7516. ; :2
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Tidskriftsartikel (refereegranskat)abstract
- The Simons Observatory (SO) is a new cosmic microwave background experiment being built on Cerro Toco in Chile, due to begin observations in the early 2020s. We describe the scientific goals of the experiment, motivate the design, and forecast its performance. SO will measure the temperature and polarization anisotropy of the cosmic microwave background in six frequency bands centered at: 27, 39, 93, 145, 225 and 280 GHz. The initial con figuration of SO will have three small-aperture 0.5-m telescopes and one large-aperture 6-m telescope, with a total of 60,000 cryogenic bolometers. Our key science goals are to characterize the primordial perturbations, measure the number of relativistic species and the mass of neutrinos, test for deviations from a cosmological constant, improve our understanding of galaxy evolution, and constrain the duration of reionization. The small aperture telescopes will target the largest angular scales observable from Chile, mapping approximate to 10% of the sky to a white noise level of 2 mu K-arcmin in combined 93 and 145 GHz bands, to measure the primordial tensor-to-scalar ratio, r, at a target level of sigma(r) = 0.003. The large aperture telescope will map approximate to 40% of the sky at arcminute angular resolution to an expected white noise level of 6 mu K-arcmin in combined 93 and 145 GHz bands, overlapping with the majority of the Large Synoptic Survey Telescope sky region and partially with the Dark Energy Spectroscopic Instrument. With up to an order of magnitude lower polarization noise than maps from the Planck satellite, the high-resolution sky maps will constrain cosmological parameters derived from the damping tail, gravitational lensing of the microwave background, the primordial bispectrum, and the thermal and kinematic Sunyaev-Zel'dovich effects, and will aid in delensing the large-angle polarization signal to measure the tensor-to-scalar ratio. The survey will also provide a legacy catalog of 16,000 galaxy clusters and more than 20,000 extragalactic sources.
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| 17. |
- Hodgson, J.A., et al.
(författare)
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Location of γ-ray emission and magnetic field strengths in OJ 287
- 2017
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 597, s. 80-
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Tidskriftsartikel (refereegranskat)abstract
- Context. The γ-ray BL Lac object OJ 287 is known to exhibit inner-parsec "jet-wobbling", high degrees of variability at all wavelengths and quasi-stationary features, including an apparent (≈100°) position-angle change in projection on the sky plane. Aims. Sub-50 micro-arcsecond resolution 86 GHz observations with the global mm-VLBI array (GMVA) supplement ongoing multifrequency VLBI blazar monitoring at lower frequencies. Using these maps, together with cm/mm total intensity and γ-ray observations from Fermi-LAT from 2008..2014, we aim to determine the location of γ-ray emission and to explain the inner-mas structural changes. Methods. Observations with the GMVA oer approximately double the angular resolution compared with 43 GHz VLBA observations and enable us to observe above the synchrotron self-absorption peak frequency. Fermi-LAT γ-ray data were reduced and analysed. The jet was spectrally decomposed at multiple locations along the jet. From this, we could derive estimates of the magnetic field using equipartition and synchrotron self-absorption arguments. How the field decreases down the jet provided an estimate of the distance to the jet apex and an estimate of the magnetic field strength at the jet apex and in the broad line region. Combined with accurate kinematics, we attempt to locate the site of γ-ray activity, radio flares, and spectral changes. Results. Strong γ-ray flares appeared to originate from either the so-called core region, a downstream stationary feature, or both, with γ-ray activity significantly correlated with radio flaring in the downstream quasi-stationary feature. Magnetic field estimates were determined at multiple locations along the jet, with the magnetic field found to be ≥1.6G in the core and ≤0.4G in the downstream quasi-stationary feature.We therefore found upper limits on the location of the VLBI core as ≤6.0 pc from the jet apex and determined an upper limit on the magnetic field near the jet base of the order of thousands of Gauss.
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| 18. |
- Deisenhammer, F, et al.
(författare)
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Prediction of natalizumab anti-drug antibodies persistency
- 2019
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Ingår i: Multiple sclerosis (Houndmills, Basingstoke, England). - : SAGE Publications. - 1477-0970 .- 1352-4585. ; 25:3, s. 392-398
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Tidskriftsartikel (refereegranskat)abstract
- Anti-drug antibodies (ADA) against natalizumab develop early during treatment. ADA persistency is defined by two consecutive positive results as performed by the current qualitative ELISA assay (positive/negative). Very little is known about the magnitude of the natalizumab ADA response and persistency. Design/methods: We developed a highly sensitive natalizumab ADA titration assay on the Meso Scale Discovery (MSD) platform and a pharmacokinetic (PK) assay. We included 43 patients with a positive ELISA-ADA result within 6 months of treatment initiation (baseline) of whom a follow-up serum sample was available 12–30 months after treatment start. MSD-ADA titres and drug levels were measured. Results: Median MSD-ADA titre at baseline was 4881 and 303 at follow-up. A titre of >400 at baseline had a 94% sensitivity and 89% specificity to predict ADA persistency. Reversion to ADA negativity occurred in 10 patients with mean drug levels of 10.8 μg/mL. The median trough drug level in ADA-positive samples was 0 µg/mL. PK levels and ADA titres correlated strongly negatively ( r = −0.67). Conclusion: High baseline natalizumab ADA titres accurately predict persistency. Despite continuous treatment, the majority of patients with persistent ADA had no detectable drug levels indicating loss of efficacy in line with phase 3 study results.
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| 19. |
- Fuhrmann, L., et al.
(författare)
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Detection of significant cm to sub-mm band radio and gamma-ray correlated variability in Fermi bright blazars
- 2014
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 441:3, s. 1899-1909
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Tidskriftsartikel (refereegranskat)abstract
- The exact location of the gamma-ray emitting region in blazars is still controversial. In order to attack this problem we present first results of a cross-correlation analysis between radio (11 cm to 0.8 mm wavelength, F-GAMMA programme) and gamma-ray (0.1-300 GeV) similar to 3.5 yr light curves of 54 Fermi-bright blazars. We perform a source stacking analysis and estimate significances and chance correlations using mixed source correlations. Our results reveal: (i) the first highly significant multiband radio and. gamma-ray correlations (radio lagging gamma rays) when averaging over the whole sample, (ii) average time delays (source frame: 76 +/- 23 to 7 +/- 9 d), systematically decreasing from cm to mm/sub-mm bands with a frequency dependence tau(r,gamma)(v) proportional to v(-1), in good agreement with jet opacity dominated by synchrotron self-absorption, (iii) a bulk gamma-ray production region typically located within/upstream of the 3 mm core region (tau(3mm),(gamma) = 12 +/- 8 d), (iv) mean distances between the region of. gamma-ray peak emission and the radio 'tau = 1 photosphere' decreasing from 9.8 +/- 3.0 pc (11 cm) to 0.9 +/- 1.1 pc (2 mm) and 1.4 +/- 0.8 pc (0.8 mm), (v) 3 mm/gamma-ray correlations in nine individual sources at a significance level where one is expected by chance (probability: 4 x 10(-6)), (vi) opacity and 'time lag core shift' estimates for quasar 3C 454.3 providing a lower limit for the distance of the bulk gamma-ray production region from the supermassive black hole (SMBH) of similar to 0.8-1.6 pc, i.e. at the outer edge of the broad-line region (BLR) or beyond. A 3 mm tau = 1 surface at similar to 2-3 pc from the jet base (i.e. well outside the 'canonical BLR') finally suggests that BLR material extends to several parsec distances from the SMBH.
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| 20. |
- Fuhrmann, L., et al.
(författare)
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The F-GAMMA programme : multi-frequency study of active galactic nuclei in the Fermi era Programme description and the first 2.5 years of monitoring
- 2016
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 596
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Tidskriftsartikel (refereegranskat)abstract
- Context. To fully exploit the scientific potential of the Fermi mission for the physics of active galactic nuclei (AGN), we initiated the F-GAMMA programme. Between 2007 and 2015 the F-GAMMA was the prime provider of complementary multi-frequency monitoring in the radio regime. Aims. We quantify the radio variability of gamma-ray blazars. We investigate its dependence on source class and examine whether the radio variability is related to the gamma-ray loudness. Finally, we assess the validity of a putative correlation between the two bands. Methods. The F-GAMMA performed monthly monitoring of a sample of about 60 sources at up to twelve radio frequencies between 2.64 and 228.39 GHz. We perform a time series analysis on the first 2.5-yr data set to obtain variability parameters. A maximum likelihood analysis is used to assess the significance of a correlation between radio and gamma-ray fluxes. Results. We present light curves and spectra (coherent within ten days) obtained with the Effelsberg 100 m and IRAM 30 m telescopes. All sources are variable across all frequency bands with amplitudes increasing with frequency up to rest frame frequencies of around 60-80 GHz as expected by shock-in-jet models. Compared to flat-spectrum radio quasars (FSRQs), BL Lacertae objects (BL Lacs) show systematically lower variability amplitudes, brightness temperatures, and Doppler factors at lower frequencies, while the difference vanishes towards higher ones. The time scales appear similar for the two classes. The distribution of spectral indices appears flatter or more inverted at higher frequencies for BL Lacs. Evolving synchrotron self-absorbed components can naturally account for the observed spectral variability. We find that the Fermi-detected sources show larger variability amplitudes, brightness temperatures, and Doppler factors than non-detected ones. Flux densities at 86.2 and 142.3 GHz correlate with 1 GeV fluxes at a significance level better than 3 sigma, implying that gamma rays are produced very close to the mm-band emission region.
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| 21. |
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| 22. |
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| 23. |
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| 24. |
- Ceballos, Javier, et al.
(författare)
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Synthesis of Indomorphan Pseudo-Natural Product Inhibitors of Glucose Transporters GLUT-1 and-3
- 2019
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Ingår i: Angewandte Chemie International Edition. - : Wiley-VCH Verlagsgesellschaft. - 1433-7851 .- 1521-3773. ; 58:47, s. 17016-17025
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Tidskriftsartikel (refereegranskat)abstract
- Bioactive compound design based on natural product (NP) structure may be limited because of partial coverage of NP-like chemical space and biological target space. These limitations can be overcome by combining NP-centered strategies with fragment-based compound design through combination of NP-derived fragments to afford structurally unprecedented "pseudo-natural products" (pseudo-NPs). The design, synthesis, and biological evaluation of a collection of indomorphan pseudo-NPs that combine biosynthetically unrelated indole- and morphan-alkaloid fragments are described. Indomorphane derivative Glupin was identified as a potent inhibitor of glucose uptake by selectively targeting and upregulating glucose transporters GLUT-1 and GLUT-3. Glupin suppresses glycolysis, reduces the levels of glucose-derived metabolites, and attenuates the growth of various cancer cell lines. Our findings underscore the importance of dual GLUT-1 and GLUT-3 inhibition to efficiently suppress tumor cell growth and the cellular rescue mechanism, which counteracts glucose scarcity.
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| 25. |
- Einig, Lucas, et al.
(författare)
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Deep learning denoising by dimension reduction: Application to the ORION-B line cubes
- 2023
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Ingår i: Astronomy and Astrophysics. - 0004-6361 .- 1432-0746. ; 677
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Tidskriftsartikel (refereegranskat)abstract
- Context. The availability of large bandwidth receivers for millimeter radio telescopes allows for the acquisition of position-position-frequency data cubes over a wide field of view and a broad frequency coverage. These cubes contain a lot of information on the physical, chemical, and kinematical properties of the emitting gas. However, their large size coupled with an inhomogenous signal-to-noise ratio (S/N) are major challenges for consistent analysis and interpretation. Aims. We searched for a denoising method of the low S/N regions of the studied data cubes that would allow the low S/N emission to be recovered without distorting the signals with a high S/N. Methods. We performed an in-depth data analysis of the 13CO and C17O (1-0) data cubes obtained as part of the ORION-B large program performed at the IRAM 30 m telescope. We analyzed the statistical properties of the noise and the evolution of the correlation of the signal in a given frequency channel with that of the adjacent channels. This has allowed us to propose significant improvements of typical autoassociative neural networks, often used to denoise hyperspectral Earth remote sensing data. Applying this method to the 13CO (1-0) cube, we were able to compare the denoised data with those derived with the multiple Gaussian fitting algorithm ROHSA, considered as the state-of-the-art procedure for data line cubes. Results. The nature of astronomical spectral data cubes is distinct from that of the hyperspectral data usually studied in the Earth remote sensing literature because the observed intensities become statistically independent beyond a short channel separation. This lack of redundancy in data has led us to adapt the method, notably by taking into account the sparsity of the signal along the spectral axis. The application of the proposed algorithm leads to an increase in the S/N in voxels with a weak signal, while preserving the spectral shape of the data in high S/N voxels. Conclusions. The proposed algorithm that combines a detailed analysis of the noise statistics with an innovative autoencoder architecture is a promising path to denoise radio-astronomy line data cubes. In the future, exploring whether a better use of the spatial correlations of the noise may further improve the denoising performances seems to be a promising avenue. In addition, dealing with the multiplicative noise associated with the calibration uncertainty at high S/N would also be beneficial for such large data cubes.
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| 26. |
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| 27. |
- Kramer, C., et al.
(författare)
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PACS and SPIRE photometer maps of M33: First results of the HERschel M33 Extended Survey (HERM33ES)
- 2010
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 518:Article Number: L67
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Tidskriftsartikel (refereegranskat)abstract
- Context. Within the framework of the HERM33ES key program, we are studying the star forming interstellar medium in the nearby, metal-poor spiral galaxy M33, exploiting the high resolution and sensitivity of Herschel. Aims. We use PACS and SPIRE maps at 100, 160, 250, 350, and 500 mu m wavelength, to study the variation of the spectral energy distributions (SEDs) with galacto-centric distance. Methods. Detailed SED modeling is performed using azimuthally averaged fluxes in elliptical rings of 2 kpc width, out to 8 kpc galacto-centric distance. Simple isothermal and two-component grey body models, with fixed dust emissivity index, are fitted to the SEDs between 24 mu m and 500 mu m using also MIPS/Spitzer data, to derive first estimates of the dust physical conditions. Results. The far-infrared and submillimeter maps reveal the branched, knotted spiral structure of M33. An underlying diffuse disk is seen in all SPIRE maps (250-500 mu m). Two component fits to the SEDs agree better than isothermal models with the observed, total and radially averaged flux densities. The two component model, with beta fixed at 1.5, best fits the global and the radial SEDs. The cold dust component clearly dominates; the relative mass of the warm component is less than 0.3% for all the fits. The temperature of the warm component is not well constrained and is found to be about 60 K +/- 10 K. The temperature of the cold component drops significantly from similar to 24 K in the inner 2 kpc radius to 13 K beyond 6 kpc radial distance, for the best fitting model. The gas-to-dust ratio for beta = 1.5, averaged over the galaxy, is higher than the solar value by a factor of 1.5 and is roughly in agreement with the subsolar metallicity of M33.
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| 31. |
- Roueff, Antoine, et al.
(författare)
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Bias versus variance when fitting multi-species molecular lines with a non-LTE radiative transfer model: Application to the estimation of the gas temperature and volume density
- 2024
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Ingår i: Astronomy and Astrophysics. - 0004-6361 .- 1432-0746. ; 686
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Tidskriftsartikel (refereegranskat)abstract
- Context. Robust radiative transfer techniques are requisite for efficiently extracting the physical and chemical information from molecular rotational lines. Aims. We study several hypotheses that enable robust estimations of the column densities and physical conditions when fitting one or two transitions per molecular species. We study the extent to which simplifying assumptions aimed at reducing the complexity of the problem introduce estimation biases and how to detect them. Methods. We focus on the CO and HCO+ isotopologues and analyze maps of a 50 square arcminutes field. We used the RADEX escape probability model to solve the statistical equilibrium equations and compute the emerging line profiles, assuming that all species coexist. Depending on the considered set of species, we also fixed the abundance ratio between some species and explored different values. We proposed a maximum likelihood estimator to infer the physical conditions and considered the effect of both the thermal noise and calibration uncertainty. We analyzed any potential biases induced by model misspecifications by comparing the results on the actual data for several sets of species and confirmed with Monte Carlo simulations. The variance of the estimations and the efficiency of the estimator were studied based on the Cramér-Rao lower bound. Results. Column densities can be estimated with 30% accuracy, while the best estimations of the volume density are found to be within a factor of two. Under the chosen model framework, the peak 12CO (1 -0) is useful for constraining the kinetic temperature. The thermal pressure is better and more robustly estimated than the volume density and kinetic temperature separately. Analyzing CO and HCO+ isotopologues and fitting the full line profile are recommended practices with respect to detecting possible biases. Conclusions. Combining a non-local thermodynamic equilibrium model with a rigorous analysis of the accuracy allows us to obtain an efficient estimator and identify where the model is misspecified. We note that other combinations of molecular lines could be studied in the future.
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| 32. |
- Santa-Maria, Miriam G., et al.
(författare)
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HCN emission from translucent gas and UV-illuminated cloud edges revealed by wide-field IRAM 30 m maps of the Orion B GMC: Revisiting its role as a tracer of the dense gas reservoir for star formation
- 2023
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Ingår i: Astronomy and Astrophysics. - 0004-6361 .- 1432-0746. ; 679
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Tidskriftsartikel (refereegranskat)abstract
- Context. Massive stars form within dense clumps inside giant molecular clouds (GMCs). Finding appropriate chemical tracers of the dense gas (n(H2) > several 104 cm-3 or AV > 8 mag) and linking their line luminosity with the star formation rate is of critical importance. Aims. Our aim is to determine the origin and physical conditions of the HCN-emitting gas and study their relation to those of other molecules. Methods. In the context of the IRAM 30m ORION-B large program, we present 5 deg2 (~250 pc2) HCN, HNC, HCO+, and CO J =1-0 maps of the Orion B GMC, complemented with existing wide-field [CI] 492 GHz maps, as well as new pointed observations of rotationally excited HCN, HNC, H13CN, and HN13C lines. We compare the observed HCN line intensities with radiative transfer models including line overlap effects and electron excitation. Furthermore, we study the HCN/HNC isomeric abundance ratio with updated photochemical models. Results. We spectroscopically resolve the HCN J = 1-0 hyperfine structure (HFS) components (and partially resolved J = 2-1 and 3-2 components). We detect anomalous HFS line intensity (and line width) ratios almost everywhere in the cloud. About 70% of the total HCN J = 1-0 luminosity, L′(HCN J = 1-0) = 110 K km s-1 pc-2, arises from AV < 8 mag. The HCN/CO J = 1-0 line intensity ratio, widely used as a tracer of the dense gas fraction, shows a bimodal behavior with an inflection point at AV < 3 mag typical of translucent gas and illuminated cloud edges. We find that most of the HCN J = 1-0 emission arises from extended gas with n(H2) < 104 cm-3, and even lower density gas if the ionization fraction is χe ≥10-5 and electron excitation dominates. This result contrasts with the prevailing view of HCN J = 1-0 emission as a tracer of dense gas and explains the low-AV branch of the HCN/CO J = 1-0 intensity ratio distribution. Indeed, the highest HCN/CO ratios (~ 0.1) at AV < 3 mag correspond to regions of high [CI] 492 GHz/CO J = 1-0 intensity ratios (>1) characteristic of low-density photodissociation regions. The low surface brightness (≲ 1 K km s-1) and extended HCN and HCO+ J = 1-0 emission scale with IFIR -a proxy of the stellar far-ultraviolet (FUV) radiation field -in a similar way. Together with CO J = 1-0, these lines respond to increasing IFIR up to G0 ≅ 20. On the other hand, the bright HCN J = 1-0 emission (> 6 K km s-1) from dense gas in star-forming clumps weakly responds to IFIR once the FUV field becomes too intense (G0 > 1500). In contrast, HNC J = 1-0 and [CI] 492 GHz lines weakly respond to IFIR for all G0. The different power law scalings (produced by different chemistries, densities, and line excitation regimes) in a single but spatially resolved GMC resemble the variety of Kennicutt-Schmidt law indexes found in galaxy averages. Conclusions. Given the widespread and extended nature of the [CI] 492 GHz emission, as well as its spatial correlation with that of HCO+, HCN, and 13CO J = 1-0 lines (in this order), we argue that the edges of GMCs are porous to FUV radiation from nearby massive stars. Enhanced FUV radiation favors the formation and excitation of HCN on large scales, not only in dense star-forming clumps, and it leads to a relatively low value of the dense gas mass to total luminosity ratio, α (HCN) = 29 M⊙ /(K km s-1pc2) in Orion B. As a corollary for extragalactic studies, we conclude that high HCN/CO J = 1-0 line intensity ratios do not always imply the presence of dense gas, which may be better traced by HNC than by HCN.
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| 35. |
- Braegelmann, Johannes, et al.
(författare)
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Pan-Cancer Analysis of the Mediator Complex Transcriptome Identifies CDK19 and CDK8 as Therapeutic Targets in Advanced Prostate Cancer
- 2017
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Ingår i: Clinical Cancer Research. - : American Association for Cancer Research Inc.. - 1078-0432 .- 1557-3265. ; 23:7, s. 1829-1840
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: The Mediator complex is a multiprotein assembly, which serves as a hub for diverse signaling pathways to regulate gene expression. Because gene expression is frequently altered in cancer, a systematic understanding of the Mediator complex in malignancies could foster the development of novel targeted therapeutic approaches.Experimental Design: We performed a systematic deconvolution of the Mediator subunit expression profiles across 23 cancer entities (n = 8,568) using data from The Cancer Genome Atlas (TCGA). Prostate cancer-specific findings were validated in two publicly available gene expression cohorts and a large cohort of primary and advanced prostate cancer (n = 622) stained by immunohistochemistry. The role of CDK19 and CDK8 was evaluated by siRNA-mediated gene knockdown and inhibitor treatment in prostate cancer cell lines with functional assays and gene expression analysis by RNAseq.Results: Cluster analysis of TCGA expression data segregated tumor entities, indicating tumor-type-specific Mediator complex compositions. Only prostate cancerwasmarked by high expression of CDK19. In primary prostate cancer, CDK19 was associated with increased aggressiveness and shorter disease-free survival. During cancer progression, highest levels of CDK19 and of its paralog CDK8were present inmetastases. In vitro, inhibition ofCDK19 and CDK8 by knockdown or treatment with a selective CDK8/ CDK19 inhibitor significantly decreased migration and invasion.Conclusions: Our analysis revealed distinct transcriptional expression profiles of the Mediator complex across cancer entities indicating differential modes of transcriptional regulation. Moreover, it identified CDK19 and CDK8 to be specifically overexpressed during prostate cancer progression, highlighting their potential as novel therapeutic targets in advanced prostate cancer.
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| 38. |
- Gratier, P., et al.
(författare)
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Molecular and atomic gas in the Local Group galaxy M 33
- 2010
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 522:1
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Tidskriftsartikel (refereegranskat)abstract
- We present high-resolution large-scale observations of the molecular and atomic gas in the Local Group galaxy M 33. The observations were carried out using the HEterodyne Receiver Array (HERA) at the 30 m IRAM telescope in the CO(2-1) line, achieving a resolution of 12 '' x 2.6 km s(-1), enabling individual giant molecular clouds (GMCs) to be resolved. The observed region is 650 square arcminutes mainly along the major axis and out to a radius of 8.5 kpc, and covers entirely the 2' x 40' radial strip observed with the HIFI and PACS Spectrometers as part of the HERM33ES Herschel key program. The achieved sensitivity in main-beam temperature is 20-50 mK at 2.6 km s(-1) velocity resolution. The CO(2-1) luminosity of the observed region is 1.7 +/- 0.1 x 10(7) K km s(-1) pc(2) and is estimated to be 2.8 +/- 0.3 x 10(7) K km s(-1) pc(2) for the entire galaxy, corresponding to H-2 masses of 1.9 x 10(8) M-circle dot and 3.3 x 10(8) M-circle dot respectively (including He), calculated with N(H-2)/ICO(1-0) twice the Galactic value due to the half-solar metallicity of M 33. The HI 21 cm VLA archive observations were reduced, and the mosaic was imaged and cleaned using the multi-scale task in the CASA software package, yielding a series of datacubes with resolutions ranging from 5 '' to 25 ''. The HI mass within a radius of 8.5 kpc is estimated to be 1.4 x 10(9) M-circle dot. The azimuthally averaged CO surface brightness decreases exponentially with a scale length of 1.9 +/- 0.1 kpc whereas the atomic gas surface density is constant at Sigma(HI) = 6 +/- 2 M-circle dot pc(-2) deprojected to face-on. For an N(H-2)/ICO(1-0) conversion factor twice that of the Milky Way, the central kiloparsec H-2 surface density is Sigma(H2) = 8.5 +/- 0.2 M-circle dot pc(-2). The star formation rate per unit molecular gas (SF efficiency, the rate of transformation of molecular gas into stars), as traced by the ratio of CO to H-alpha and FIR brightness, is constant with radius. The SFE, with a N(H-2)/ICO(1-0) factor twice galactic, appears 2-4 times greater than for large spiral galaxies. A morphological comparison of molecular and atomic gas with tracers of star formation is presented showing good agreement between these maps both in terms of peaks and holes. A few exceptions are noted. Several spectra, including those of a molecular cloud situated more than 8 kpc from the galaxy center, are presented.
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| 39. |
- Keck, Michaela Kristina, et al.
(författare)
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Amplification of the PLAG-family genes—PLAGL1 and PLAGL2—is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification
- 2023
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Ingår i: Acta Neuropathologica. - : Springer Science and Business Media LLC. - 0001-6322 .- 1432-0533. ; 145:1, s. 49-69
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Tidskriftsartikel (refereegranskat)abstract
- Pediatric central nervous system (CNS) tumors represent the most common cause of cancer-related death in children aged 0–14 years. They differ from their adult counterparts, showing extensive clinical and molecular heterogeneity as well as a challenging histopathological spectrum that often impairs accurate diagnosis. Here, we use DNA methylation-based CNS tumor classification in combination with copy number, RNA-seq, and ChIP-seq analysis to characterize a newly identified CNS tumor type. In addition, we report histology, patient characteristics, and survival data in this tumor type. We describe a biologically distinct pediatric CNS tumor type (n = 31 cases) that is characterized by focal high-level amplification and resultant overexpression of either PLAGL1 or PLAGL2, and an absence of recurrent genetic alterations characteristic of other pediatric CNS tumor types. Both genes act as transcription factors for a regulatory subset of imprinted genes (IGs), components of the Wnt/β-Catenin pathway, and the potential drug targets RET and CYP2W1, which are also specifically overexpressed in this tumor type. A derived PLAGL-specific gene expression signature indicates dysregulation of imprinting control and differentiation/development. These tumors occurred throughout the neuroaxis including the cerebral hemispheres, cerebellum, and brainstem, and were predominantly composed of primitive embryonal-like cells lacking robust expression of markers of glial or neuronal differentiation (e.g., GFAP, OLIG2, and synaptophysin). Tumors with PLAGL1 amplification were typically diagnosed during adolescence (median age 10.5 years), whereas those with PLAGL2 amplification were diagnosed during early childhood (median age 2 years). The 10-year overall survival was 66% for PLAGL1-amplified tumors, 25% for PLAGL2-amplified tumors, 18% for male patients, and 82% for female patients. In summary, we describe a new type of biologically distinct CNS tumor characterized by PLAGL1/2 amplification that occurs predominantly in infants and toddlers (PLAGL2) or adolescents (PLAGL1) which we consider best classified as a CNS embryonal tumor and which is associated with intermediate survival. The cell of origin and optimal treatment strategies remain to be defined.
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| 42. |
- Okabe, Nobuhiro, et al.
(författare)
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Active gas features in three HSC-SSP CAMIRA clusters revealed by high angular resolution analysis of MUSTANG-2 SZE and XXL X-ray observations
- 2021
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Ingår i: Monthly Notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 501:2, s. 1701-1732
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Tidskriftsartikel (refereegranskat)abstract
- We present results from simultaneous modelling of high angular resolution GBT/MUSTANG-2 90 GHz Sunyaev-Zel'dovich effect (SZE) measurements and XMM-XXL X-ray images of three rich galaxy clusters selected from the HSC-SSP Survey. The combination of high angular resolution SZE and X-ray imaging enables a spatially resolved multicomponent analysis, which is crucial to understand complex distributions of cluster gas properties. The targeted clusters have similar optical richnesses and redshifts, but exhibit different dynamical states in their member galaxy distributions: a single-peaked cluster, a double-peaked cluster, and a cluster belonging to a supercluster. A large-scale residual pattern in both regular Compton-parameter y and X-ray surface brightness distributions is found in the single-peaked cluster, indicating a sloshing mode. The double-peaked cluster shows an X-ray remnant cool core between two SZE peaks associated with galaxy concentrations. The temperatures of the two peaks reach similar to 20-30 keV in contrast to the cool core component of similar to 2 keV, indicating a violent merger. The main SZE signal for the supercluster is elongated along a direction perpendicular to the major axis of the X-ray core, suggesting a minor merger before core passage. The S-X and y distributions are thus perturbed at some level, regardless of the optical properties. We find that the integrated Compton y parameter and the temperature for the major merger are boosted from those expected by the weak-lensing mass and those for the other two clusters show no significant deviations, which is consistent with predictions of numerical simulations.
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| 43. |
- Sievers, M., et al.
(författare)
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Gene Expression and Immunohistochemistry in Adipose Tissue of HIV Type 1-Infected Patients with Nucleoside Analogue Reverse-Transcriptase Inhibitor-Associated Lipoatrophy
- 2009
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Ingår i: Journal of Infectious Diseases. - : Oxford University Press. - 0022-1899 .- 1537-6613. ; 200:2, s. 252-262
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND:Long-term use of both zidovudine (AZT) and stavudine (d4T) is associated with lipoatrophy, but it occurs possibly through different mechanisms.METHODS:Surgical biopsy specimens of subcutaneous adipose tissue were obtained from 18 human immunodeficiency virus type 1 (HIV-1)-infected lipoatrophic patients (the LA+ group) who were treated with either zidovudine (the AZT+LA+ group; n = 10) or stavudine (the d4T+LA+ group; n = 8) and from 10 nonlipoatrophic HIV-1-infected patients (the LA- group) who received antiretroviral therapy. Mitochondrial DNA (mtDNA) copy numbers, gene expression, and immunohistochemistry data were analyzed.RESULTS:mtDNA copy numbers were significantly reduced in the LA+ group, compared with the LA- group, and in the d4T+LA+ group, compared with the AZT+LA+ group. The ratio of mtDNA-encoded cytochrome COX3 to nuclear DNA-encoded COX4 expression was significantly lower in the LA+ group than in the LA- group. Compared with the LA- group, the LA+ group had significantly lower expression of genes involved in adipogenesis (SREBP1c and CEBPB), lipid (fatty acid synthase), and glucose (GLUT4) metabolism. Expression of genes involved in mitochondrial biogenesis (PGC1B), apoptosis (FAS), inflammation (IL1B), oxidative stress (PCNA and SOD1), and lamin B was significantly higher in the LA+ group than in the LA- group. The d4T+LA+ group had significantly lower expression of genes involved in mitochondrial biogenesis (POLG1), energy metabolism (the COX3/COX4 ratio), adipogenesis (SREBP1c and CEBPA), perilipin, and hexokinase than did the AZT+LA+ group. There were 7-fold more macrophages in adipose tissue specimens obtained from patients in the LA+ group, compared with the LA- group.CONCLUSIONS:Lipoatrophy is characterized by mtDNA depletion, inflammation, and signs of apoptosis. Changes were more profound in the d4T+LA+ group than in the AZT+LA+ group
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