| 1. |
- Iwaya, Leonardo H, et al.
(författare)
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Mobile health in emerging countries : a survey of research initiatives in Brazil.
- 2013
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Ingår i: International Journal of Medical Informatics. - : Elsevier BV. - 1386-5056 .- 1872-8243. ; 82:5, s. 283-298
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To conduct a comprehensive survey of mobile health (mHealth) research initiatives in Brazil, discussing current challenges, gaps, opportunities and tendencies.METHODS: Systematic review of publicly available electronic documents related to mHealth, including scientific publications, technical reports and descriptions of commercial products. Specifically, 42 projects are analyzed and classified according to their goals. This analysis considers aspects such as security features provided (if any), the health condition that are focus of attention, the main providers involved in the projects development and deployment, types of devices used, target users, where the projects are tested and/or deployed, among others.RESULTS: The study shows a large number (86%) of mHealth solutions focused on the following categories: health surveys, surveillance, patient records and monitoring. Meanwhile, treatment compliance, awareness raising and decision support systems are less explored. The main providers of solutions are the universities (56%) and health units (32%), with considerable cooperation between such entities. Most applications have physicians (55%) and Community Health Agents (CHAs) (33%) as targeted users, the latter being important elements in nation-wide governmental health programs. Projects focused on health managers, however, are a minority (5%). The majority of projects do not focus on specific diseases but rather general health (57%), although solutions for hearth conditions are reasonably numerous (21%). Finally, the lack of security mechanisms in the majority of the surveyed solutions (52%) may hinder their deployment in the field due to the lack of compliance with general regulations for medical data handling.CONCLUSION: There are currently many mHealth initiatives in Brazil, but some areas have not been much explored, such as solutions for treatment compliance and awareness raising, as well as decision support systems. Another research trend worth exploring refers to creating interoperable security mechanisms, especially for widely explored mHealth categories such as health surveys, patient records and monitoring. Challenges for the expansion of mHealth solutions, both in number and coverage, include the further involvement of health managers in the deployment of such solutions and in coordinating efforts among health and research institutions interested in the mHealth trend, possibly exploring the widespread presence of CHAs around the country as users of such technology.
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| 2. |
- Barros, B M, et al.
(författare)
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Classifying Security Threats in Cloud Networking
- 2015
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Ingår i: Proceedings of the 5th International Conference on Cloud Computing and Services Science. - : SciTePress. - 9789897581045 ; , s. 214-220
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Konferensbidrag (refereegranskat)abstract
- A central component of managing risks in cloud computing is to understand the nature of security threats. The relevance of security concerns are evidenced by the efforts from both the academic community and technological organizations such as NIST, ENISA and CSA, to investigate security threats and vulnerabilities related to cloud systems. Provisioning secure virtual networks (SVNs) in a multi-tenant environment is a fundamental aspect to ensure trust in public cloud systems and to encourage their adoption. However, comparing existing SVN-oriented solutions is a difficult task due to the lack of studies summarizing the main concerns of network virtualization and providing a comprehensive list of threats those solutions should cover. To address this issue, this paper presents a threat classification for cloud networking, describing threat categories and attack scenarios that should be taken into account when designing, comparing, or categorizing solutions. The classification is based o n the CSA threat report, building upon studies and surveys from the specialized literature to extend the CSA list of threats and to allow a more detailed analysis of cloud network virtualization issues.
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| 3. |
- Holmes, Emily A., et al.
(författare)
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Applications of time-series analysis to mood fluctuations in bipolar disorder to promote treatment innovation : a case series.
- 2016
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Ingår i: Translational Psychiatry. - : Springer Science and Business Media LLC. - 2158-3188. ; 6
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Tidskriftsartikel (refereegranskat)abstract
- Treatment innovation for bipolar disorder has been hampered by a lack of techniques to capture a hallmark symptom: ongoing mood instability. Mood swings persist during remission from acute mood episodes and impair daily functioning. The last significant treatment advance remains Lithium (in the 1970s), which aids only the minority of patients. There is no accepted way to establish proof of concept for a new mood-stabilizing treatment. We suggest that combining insights from mood measurement with applied mathematics may provide a step change: repeated daily mood measurement (depression) over a short time frame (1 month) can create individual bipolar mood instability profiles. A time-series approach allows comparison of mood instability pre- and post-treatment. We test a new imagery-focused cognitive therapy treatment approach (MAPP; Mood Action Psychology Programme) targeting a driver of mood instability, and apply these measurement methods in a non-concurrent multiple baseline design case series of 14 patients with bipolar disorder. Weekly mood monitoring and treatment target data improved for the whole sample combined. Time-series analyses of daily mood data, sampled remotely (mobile phone/Internet) for 28 days pre- and post-treatment, demonstrated improvements in individuals' mood stability for 11 of 14 patients. Thus the findings offer preliminary support for a new imagery-focused treatment approach. They also indicate a step in treatment innovation without the requirement for trials in illness episodes or relapse prevention. Importantly, daily measurement offers a description of mood instability at the individual patient level in a clinically meaningful time frame. This costly, chronic and disabling mental illness demands innovation in both treatment approaches (whether pharmacological or psychological) and measurement tool: this work indicates that daily measurements can be used to detect improvement in individual mood stability for treatment innovation (MAPP).
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| 4. |
- Simplício, M A, et al.
(författare)
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Method and Apparatus for Securing a Connection in a Communications Network
- 2015
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Patent (populärvet., debatt m.m.)abstract
- A method of securing a session between a Network Application Function, NAF, and a User Equipment, UE, connected to a network. The NAF is assigned a NAF identifier, NAF_id, using the Generic Bootstrapping Architecture, GBA, or a similar architecture and a shared secret is established between the UE and the NAF (S7.1). An application request containing a bootstrapping transaction identifier is sent to the NAF from the UE (S7.2) and an authentication request comprising the bootstrapping transaction identifier, the NAF_id, and information derived from the shared secret is sent to a Bootstrapping Server Function, BSF, from the NAF (S7.4). The BSF and the UE determine a NAF key, Ks_NAF, by using a modified parameter in place of or in addition to an original parameter in a key derivation function, the modified parameter being derived from the shared secret and the original parameter of the key derivation function (S7.5). This NAF key is transmitted from the BSF to the NAF (S7.6) and used to secure communications between the NAF and the UE (S7.7). Also provided are apparatus to act as a NAF, UE, and BSF in the method above.
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| 5. |
- Simplício, M A, Jr, et al.
(författare)
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SecourHealth : a delay-tolerant security framework for mobile health data collection.
- 2015
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Ingår i: IEEE journal of biomedical and health informatics. - 2168-2194 .- 2168-2208. ; 19:2, s. 761-772
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Tidskriftsartikel (refereegranskat)abstract
- Security is one of the most imperative requirements for the success of systems that deal with highly sensitive data, such as medical information. However, many existing mobile health solutions focused on collecting patients' data at their homes that do not include security among their main requirements. Aiming to tackle this issue, this paper presents SecourHealth, a lightweight security framework focused on highly sensitive data collection applications. SecourHealth provides many security services for both stored and in-transit data, displaying interesting features such as tolerance to lack of connectivity (a common issue when promoting health in remote locations) and the ability to protect data even if the device is lost/stolen or shared by different data collection agents. Together with the system's description and analysis, we also show how SecourHealth can be integrated into a real data collection solution currently deployed in the city of Sao Paulo, Brazil.
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| 6. |
- Clark, Ian A., et al.
(författare)
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First steps in using machine learning on fMRI data to predict intrusive memories of traumatic film footage
- 2014
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Ingår i: Behaviour Research and Therapy. - : PERGAMON-ELSEVIER SCIENCE LTD. - 0005-7967 .- 1873-622X. ; 62, s. 37-46
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Tidskriftsartikel (refereegranskat)abstract
- After psychological trauma, why do some only some parts of the traumatic event return as intrusive memories while others do not? Intrusive memories are key to cognitive behavioural treatment for post-traumatic stress disorder, and an aetiological understanding is warranted. We present here analyses using multivariate pattern analysis (MVPA) and a machine learning classifier to investigate whether peri-traumatic brain activation was able to predict later intrusive memories (i.e. before they had happened). To provide a methodological basis for understanding the context of the current results, we first show how functional magnetic resonance imaging (fMRI) during an experimental analogue of trauma (a trauma film) via a prospective event-related design was able to capture an individual's later intrusive memories. Results showed widespread increases in brain activation at encoding when viewing a scene in the scanner that would later return as an intrusive memory in the real world. These fMRI results were replicated in a second study. While traditional mass univariate regression analysis highlighted an association between brain processing and symptomatology, this is not the same as prediction. Using MVPA and a machine learning classifier, it was possible to predict later intrusive memories across participants with 68% accuracy, and within a participant with 97% accuracy; i.e. the classifier could identify out of multiple scenes those that would later return as an intrusive memory. We also report here brain networks key in intrusive memory prediction. MVPA opens the possibility of decoding brain activity to reconstruct idiosyncratic cognitive events with relevance to understanding and predicting mental health symptoms. (C) 2014 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).
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| 7. |
- Hales, Susie A., et al.
(författare)
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Imagery-Focused Cognitive Therapy (ImCT) for Mood Instability and Anxiety in a Small Sample of Patients with Bipolar Disorder : a Pilot Clinical Audit
- 2018
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Ingår i: Behavioural and Cognitive Psychotherapy. - : CAMBRIDGE UNIV PRESS. - 1352-4658 .- 1469-1833. ; 46:6, s. 706-725
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Tidskriftsartikel (refereegranskat)abstract
- Background: Despite the global impact of bipolar disorder (BD), treatment success is limited. Challenges include syndromal and subsyndromal mood instability, comorbid anxiety, and uncertainty around mechanisms to target. The Oxford Mood Action Psychology Programme (OxMAPP) offered a novel approach within a cognitive behavioural framework, via mental imagery-focused cognitive therapy (ImCT). Aims: This clinical audit evaluated referral rates, clinical outcomes and patient satisfaction with the OxMAPP service. Method: Eleven outpatients with BD received ImCT in addition to standard psychiatric care. Mood data were collected weekly from 6 months pre-treatment to 6 months post-treatment via routine mood monitoring. Anxiety was measured weekly from start of treatment until 1 month post-treatment. Patient feedback was provided via questionnaire. Results: Referral and treatment uptake rates indicated acceptability to referrers and patients. From pre- to post-treatment, there was (i) a significant reduction in the duration of depressive episode relapses, and (ii) a non-significant trend towards a reduction in the number of episodes, with small to medium effect size. There was a large effect size for the reduction in weekly anxiety symptoms from assessment to 1 month follow-up. Patient feedback indicated high levels of satisfaction with ImCT, and underscored the importance of the mental imagery focus. Conclusions: This clinical audit provides preliminary evidence that ImCT can help improve depressive and anxiety symptoms in BD as part of integrated clinical care, with high patient satisfaction and acceptability. Formal assessment designs are needed to further test the feasibility and efficacy of the new ImCT treatment on anxiety and mood instability.
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| 8. |
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| 9. |
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| 10. |
- Ivins, Annabel, et al.
(författare)
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Mental imagery in bipolar affective disorder versus unipolar depression : Investigating cognitions at times of 'positive' mood
- 2014
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Ingår i: Journal of Affective Disorders. - : ELSEVIER SCIENCE BV. - 0165-0327 .- 1573-2517. ; 166, s. 234-242
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Tidskriftsartikel (refereegranskat)abstract
- Background: Compared to unipolar depression (UD), depressed mood in bipolar disorder (BD) has been associated with amplified negative mental imagery of the future ('flashforwards'). However, imagery characteristics during positive mood remain poorly explored. We hypothesise first, that unlike UD patients, the most significant positive images of BD patients will be 'flashforwards' (rather than past memories). Second, that BD patients will experience more frequent (and more 'powerful') positive imagery as compared to verbal thoughts and third, that behavioural activation scores will be predicted by imagery variables in the BD group. Methods: BD (n=26) and UD (n=26) patients completed clinical and trait imagery measures followed by an Imagery Interview and a measure of behavioural activation. Results: Compared to UD, BD patients reported more 'flashforwards compared to past memories and rated their 'flashforwards' as more vivid, exciting and pleasurable. Only the BD group found positive imagery more powerful', (preoccupying, 'real' and compelling) as compared to verbal thoughts. Imagery-associated pleasure predicted levels of drive and reward responsiveness in the BD group. Limitations: A limitation in the study was the retrospective design. Moreover pathological and non-pathological periods of "positive" mood were not distinguished in the BD sample. Conclusions: This study reveals BD patients experience positive 'flashforward' imagery in positive mood, with more intense qualities than UD patients. This could contribute to the amplification of emotional states and goal directed behaviour leading into mania, and differentiate BD from UD. (C) 2014 The Authors. Published by Elsevier B.V.
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| 11. |
- Ng, Roger M. K., et al.
(författare)
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'Flash-forwards' and suicidal ideation : A prospective investigation of mental imagery, entrapment and defeat in a cohort from the Hong Kong Mental Morbidity Survey
- 2016
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Ingår i: Psychiatry Research. - : ELSEVIER IRELAND LTD. - 0165-1781 .- 1872-7123. ; 246, s. 453-460
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Tidskriftsartikel (refereegranskat)abstract
- 'Flash-forwards' - mental images of suicide - have been reported in selected Caucasian samples. Perceptions of defeat and entrapment are considered to be associated with suicidal ideation. We aimed to investigate (1) the presence of suicidal flash-forwards in people with recent suicidal ideation versus those without such ideation in an Asian sample, and (2) associations between suicidal flash-forwards, and perceptions of entrapment accounting for suicidal ideation. Eighty two suicidal and 80 non-suicidal participants from the Hong Kong Mental Morbidity Survey completed questionnaires including suicidal ideation, presence of suicidal flash-forward images, defeat and entrapment, at baseline and seven weeks later. Suicidal 'flash-forwards' were present only in suicidal cases. People with recent suicidal ideation and suicidal flash-forwards had more severe suicidal ideation than those without flash-forwards. Compared to those without suicidal ideation, people with recent suicidal ideation reported higher entrapment and defeat levels. Resolution of suicidal ideation over time was associated with fewer suicidal flash-forwards and reduced entrapment perceptions. At baseline and seven weeks, suicidal ideation was predicted by an interaction between suicidal flash-forwards presence and perceptions of entrapment. Mental imagery of suicide appears to be associated with suicidal ideation, and may represent a novel target in suicidal risk assessment and prevention.
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| 12. |
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| 13. |
- Näslund, Mats, et al.
(författare)
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Encrypting and Storing Data
- 2016
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Patent (populärvet., debatt m.m.)abstract
- Methods and apparatus for encrypting and storing data. The methods and apparatus provide different levels of security and usability. The methods and apparatus generate two or more keys based on a shared secret made available to a user equipment and a server. The two or more keys comprise at least one perfect forward secrecy key, and at least one limited forward secrecy key. The methods and apparatus encrypt data using at least one of the two or more keys. The methods and apparatus store the encrypted data in a memory of the user equipment and/or transmit the data from the user equipment to the server
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| 14. |
- Santana, Maxwell B, et al.
(författare)
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Spinal cord stimulation alleviates motor deficits in a primate model of Parkinson disease.
- 2014
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Ingår i: Neuron. - : Elsevier BV. - 0896-6273. ; 84:4, s. 716-722
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Tidskriftsartikel (refereegranskat)abstract
- Although deep brain electrical stimulation can alleviate the motor symptoms of Parkinson disease (PD), just a small fraction of patients with PD can take advantage of this procedure due to its invasive nature. A significantly less invasive method-epidural spinal cord stimulation (SCS)-has been suggested as an alternative approach for symptomatic treatment of PD. However, the mechanisms underlying motor improvements through SCS are unknown. Here, we show that SCS reproducibly alleviates motor deficits in a primate model of PD. Simultaneous neuronal recordings from multiple structures of the cortico-basal ganglia-thalamic loop in parkinsonian monkeys revealed abnormal highly synchronized neuronal activity within each of these structures and excessive functional coupling among them. SCS disrupted this pathological circuit behavior in a manner that mimics the effects caused by pharmacological dopamine replacement therapy or deep brain stimulation. These results suggest that SCS should be considered as an additional treatment option for patients with PD.
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