| 1. |
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| 2. |
- Kinyoki, DK, et al.
(författare)
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Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017
- 2020
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Ingår i: Nature medicine. - : Springer Science and Business Media LLC. - 1546-170X .- 1078-8956. ; 26:5, s. 750-759
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Tidskriftsartikel (refereegranskat)abstract
- A double burden of malnutrition occurs when individuals, household members or communities experience both undernutrition and overweight. Here, we show geospatial estimates of overweight and wasting prevalence among children under 5 years of age in 105 low- and middle-income countries (LMICs) from 2000 to 2017 and aggregate these to policy-relevant administrative units. Wasting decreased overall across LMICs between 2000 and 2017, from 8.4% (62.3 (55.1–70.8) million) to 6.4% (58.3 (47.6–70.7) million), but is predicted to remain above the World Health Organization’s Global Nutrition Target of <5% in over half of LMICs by 2025. Prevalence of overweight increased from 5.2% (30 (22.8–38.5) million) in 2000 to 6.0% (55.5 (44.8–67.9) million) children aged under 5 years in 2017. Areas most affected by double burden of malnutrition were located in Indonesia, Thailand, southeastern China, Botswana, Cameroon and central Nigeria. Our estimates provide a new perspective to researchers, policy makers and public health agencies in their efforts to address this global childhood syndemic.
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| 3. |
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| 4. |
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| 5. |
- Ikuta, K. S., et al.
(författare)
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Global mortality associated with 33 bacterial pathogens in 2019: a systematic analysis for the Global Burden of Disease Study 2019
- 2022
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Ingår i: Lancet. - : Elsevier BV. - 0140-6736. ; 400:10369, s. 2221-2248
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Tidskriftsartikel (refereegranskat)abstract
- Background Reducing the burden of death due to infection is an urgent global public health priority. Previous studies have estimated the number of deaths associated with drug-resistant infections and sepsis and found that infections remain a leading cause of death globally. Understanding the global burden of common bacterial pathogens (both susceptible and resistant to antimicrobials) is essential to identify the greatest threats to public health. To our knowledge, this is the first study to present global comprehensive estimates of deaths associated with 33 bacterial pathogens across 11 major infectious syndromes. Methods We estimated deaths associated with 33 bacterial genera or species across 11 infectious syndromes in 2019 using methods from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, in addition to a subset of the input data described in the Global Burden of Antimicrobial Resistance 2019 study. This study included 343 million individual records or isolates covering 11 361 study-location-years. We used three modelling steps to estimate the number of deaths associated with each pathogen: deaths in which infection had a role, the fraction of deaths due to infection that are attributable to a given infectious syndrome, and the fraction of deaths due to an infectious syndrome that are attributable to a given pathogen. Estimates were produced for all ages and for males and females across 204 countries and territories in 2019. 95% uncertainty intervals (UIs) were calculated for final estimates of deaths and infections associated with the 33 bacterial pathogens following standard GBD methods by taking the 2.5th and 97.5th percentiles across 1000 posterior draws for each quantity of interest. Findings From an estimated 13.7 million (95% UI 10.9-17.1) infection-related deaths in 2019, there were 7.7 million deaths (5.7-10.2) associated with the 33 bacterial pathogens (both resistant and susceptible to antimicrobials) across the 11 infectious syndromes estimated in this study. We estimated deaths associated with the 33 bacterial pathogens to comprise 13.6% (10.2-18.1) of all global deaths and 56.2% (52.1-60.1) of all sepsis-related deaths in 2019. Five leading pathogens-Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae, Klebsiella pneumoniae, and Pseudomonas aeruginosa-were responsible for 54.9% (52.9-56.9) of deaths among the investigated bacteria. The deadliest infectious syndromes and pathogens varied by location and age. The age-standardised mortality rate associated with these bacterial pathogens was highest in the sub-Saharan Africa super-region, with 230 deaths (185-285) per 100 000 population, and lowest in the high-income super-region, with 52.2 deaths (37.4-71.5) per 100 000 population. S aureus was the leading bacterial cause of death in 135 countries and was also associated with the most deaths in individuals older than 15 years, globally. Among children younger than 5 years, S pneumoniae was the pathogen associated with the most deaths. In 2019, more than 6 million deaths occurred as a result of three bacterial infectious syndromes, with lower respiratory infections and bloodstream infections each causing more than 2 million deaths and peritoneal and intra-abdominal infections causing more than 1 million deaths. Interpretation The 33 bacterial pathogens that we investigated in this study are a substantial source of health loss globally, with considerable variation in their distribution across infectious syndromes and locations. Compared with GBD Level 3 underlying causes of death, deaths associated with these bacteria would rank as the second leading cause of death globally in 2019; hence, they should be considered an urgent priority for intervention within the global health community. Strategies to address the burden of bacterial infections include infection prevention, optimised use of antibiotics, improved capacity for microbiological analysis, vaccine development, and improved and more pervasive use of available vaccines. These estimates can be used to help set priorities for vaccine need, demand, and development. Copyright (c) 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.
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| 6. |
- Kassebaum, Nicholas J., et al.
(författare)
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Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990-2015 : a systematic analysis for the Global Burden of Disease Study 2015
- 2016
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Ingår i: The Lancet. - 0140-6736 .- 1474-547X. ; 388:10053, s. 1603-1658
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Tidskriftsartikel (refereegranskat)abstract
- Background Healthy life expectancy (HALE) and disability-adjusted life-years (DALYs) provide summary measures of health across geographies and time that can inform assessments of epidemiological patterns and health system performance, help to prioritise investments in research and development, and monitor progress toward the Sustainable Development Goals (SDGs). We aimed to provide updated HALE and DALYs for geographies worldwide and evaluate how disease burden changes with development. Methods We used results from the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015) for all-cause mortality, cause-specific mortality, and non-fatal disease burden to derive HALE and DALYs by sex for 195 countries and territories from 1990 to 2015. We calculated DALYs by summing years of life lost (YLLs) and years of life lived with disability (YLDs) for each geography, age group, sex, and year. We estimated HALE using the Sullivan method, which draws from age-specific death rates and YLDs per capita. We then assessed how observed levels of DALYs and HALE differed from expected trends calculated with the Socio-demographic Index (SDI), a composite indicator constructed from measures of income per capita, average years of schooling, and total fertility rate. Findings Total global DALYs remained largely unchanged from 1990 to 2015, with decreases in communicable, neonatal, maternal, and nutritional (Group 1) disease DALYs off set by increased DALYs due to non-communicable diseases (NCDs). Much of this epidemiological transition was caused by changes in population growth and ageing, but it was accelerated by widespread improvements in SDI that also correlated strongly with the increasing importance of NCDs. Both total DALYs and age-standardised DALY rates due to most Group 1 causes significantly decreased by 2015, and although total burden climbed for the majority of NCDs, age-standardised DALY rates due to NCDs declined. Nonetheless, age-standardised DALY rates due to several high-burden NCDs (including osteoarthritis, drug use disorders, depression, diabetes, congenital birth defects, and skin, oral, and sense organ diseases) either increased or remained unchanged, leading to increases in their relative ranking in many geographies. From 2005 to 2015, HALE at birth increased by an average of 2.9 years (95% uncertainty interval 2.9-3.0) for men and 3.5 years (3.4-3.7) for women, while HALE at age 65 years improved by 0.85 years (0.78-0.92) and 1.2 years (1.1-1.3), respectively. Rising SDI was associated with consistently higher HALE and a somewhat smaller proportion of life spent with functional health loss; however, rising SDI was related to increases in total disability. Many countries and territories in central America and eastern sub-Saharan Africa had increasingly lower rates of disease burden than expected given their SDI. At the same time, a subset of geographies recorded a growing gap between observed and expected levels of DALYs, a trend driven mainly by rising burden due to war, interpersonal violence, and various NCDs. Interpretation Health is improving globally, but this means more populations are spending more time with functional health loss, an absolute expansion of morbidity. The proportion of life spent in ill health decreases somewhat with increasing SDI, a relative compression of morbidity, which supports continued efforts to elevate personal income, improve education, and limit fertility. Our analysis of DALYs and HALE and their relationship to SDI represents a robust framework on which to benchmark geography-specific health performance and SDG progress. Country-specific drivers of disease burden, particularly for causes with higher-than-expected DALYs, should inform financial and research investments, prevention efforts, health policies, and health system improvement initiatives for all countries along the development continuum.
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| 7. |
- Gill, J. P. S., et al.
(författare)
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Pesticide Residues in Peri-Urban Bovine Milk from India and Risk Assessment : A Multicenter Study
- 2020
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Ingår i: Scientific Reports. - : NATURE PUBLISHING GROUP. - 2045-2322. ; 10:1
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Tidskriftsartikel (refereegranskat)abstract
- Pesticides residue poses serious concerns to human health. The present study was carried out to determine the pesticide residues of peri-urban bovine milk (n=1183) from five different sites (Bangalore, Bhubaneswar, Guwahati, Ludhiana and Udaipur) in India and dietary exposure risk assessment to adults and children. Pesticide residues were estimated using gas chromatography with flame thermionic and electron capture detectors followed by confirmation on gas chromatography-mass spectrometer. The results noticed the contamination of milk with hexachlorocyclohexane (HCH), dichloro-diphenyl trichloroethane (DDT), endosulfan, cypermethrin, cyhalothrin, permethrin, chlorpyrifos, ethion and profenophos pesticides. The residue levels in some of the milk samples were observed to be higher than the respective maximum residue limits (MRLs) for pesticide. Milk samples contamination was found highest in Bhubaneswar (11.2%) followed by Bangalore (9.3%), Ludhiana (6.9%), Udaipur (6.4%) and Guwahati (6.3%). The dietary risk assessment of pesticides under two scenarios i.e. lower-bound scenario (LB) and upper-bound (UB) revealed that daily intake of pesticides was substantially below the prescribed acceptable daily intake except for fipronil in children at UB. The non-cancer risk by estimation of hazard index (HI) was found to be below the target value of one in adults at all five sites in India. However, for children at the UB level, the HI for lindane, DDT and ethion exceeded the value of one in Ludhiana and Udaipur. Cancer risk for adults was found to be in the recommended range of United States environment protection agency (USEPA), while it exceeded the USEPA values for children.
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| 8. |
- James, SL, et al.
(författare)
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Global injury morbidity and mortality from 1990 to 2017: results from the Global Burden of Disease Study 2017
- 2020
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Ingår i: Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention. - : BMJ. - 1475-5785. ; 26:SUPP_1Supp 1, s. 96-114
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Tidskriftsartikel (refereegranskat)abstract
- Past research in population health trends has shown that injuries form a substantial burden of population health loss. Regular updates to injury burden assessments are critical. We report Global Burden of Disease (GBD) 2017 Study estimates on morbidity and mortality for all injuries.MethodsWe reviewed results for injuries from the GBD 2017 study. GBD 2017 measured injury-specific mortality and years of life lost (YLLs) using the Cause of Death Ensemble model. To measure non-fatal injuries, GBD 2017 modelled injury-specific incidence and converted this to prevalence and years lived with disability (YLDs). YLLs and YLDs were summed to calculate disability-adjusted life years (DALYs).FindingsIn 1990, there were 4 260 493 (4 085 700 to 4 396 138) injury deaths, which increased to 4 484 722 (4 332 010 to 4 585 554) deaths in 2017, while age-standardised mortality decreased from 1079 (1073 to 1086) to 738 (730 to 745) per 100 000. In 1990, there were 354 064 302 (95% uncertainty interval: 338 174 876 to 371 610 802) new cases of injury globally, which increased to 520 710 288 (493 430 247 to 547 988 635) new cases in 2017. During this time, age-standardised incidence decreased non-significantly from 6824 (6534 to 7147) to 6763 (6412 to 7118) per 100 000. Between 1990 and 2017, age-standardised DALYs decreased from 4947 (4655 to 5233) per 100 000 to 3267 (3058 to 3505).InterpretationInjuries are an important cause of health loss globally, though mortality has declined between 1990 and 2017. Future research in injury burden should focus on prevention in high-burden populations, improving data collection and ensuring access to medical care.
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| 9. |
- Momin, Tooba, et al.
(författare)
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ZFP36 ring finger protein like 1 significantly suppresses human coronavirus OC43 replication
- 2023
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Ingår i: PeerJ. - : PEERJ INC. - 2167-8359. ; 11
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Tidskriftsartikel (refereegranskat)abstract
- CCCH-type zinc figure proteins (ZFP) are small cellular proteins that are structurally maintained by zinc ions. Zinc ions coordinate the protein structure in a tetrahedral geometry by binding to cystine-cystine or cysteines-histidine amino acids. ZFP's unique structure enables it to interact with a wide variety of molecules including RNA; thus, ZFP modulates several cellular processes including the host immune response and virus replication. CCCH-type ZFPs have shown their antiviral efficacy against several DNA and RNA viruses. However, their role in the human coronavirus is little explored. We hypothesized that ZFP36L1 also suppresses the human coronavirus. To test our hypothesis, we used OC43 human coronavirus (HCoV) strain in our study. We overexpressed and knockdown ZFP36L1 in HCT-8 cells using lentivirus transduction. Wild type, ZFP36L1 overexpressed, and ZFP36L1 knockdown cells were each infected with HCoV-OC43, and the virus titer in each cell line was measured over 96 hours post-infection (p.i.). Our results show that HCoV-OC43 replication was significantly reduced with ZFP36L1 overexpression while ZFP36L1 knockdown significantly enhanced virus replication. ZFP36L1 knockdown HCT-8 cells started producing infectious virus at 48 hours p.i. which was an earlier timepoint as compared to wild-type and ZFP36L1 overexpressed cells. Wild-type and ZFP36L1 overexpressed HCT-8 cells started producing infectious virus at 72 hours p.i. Overall, the current study showed that overexpression of ZFP36L1 suppressed human coronavirus (OC43) production.
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| 10. |
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| 11. |
- Rao Vuddanda, Parameswara, et al.
(författare)
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Development of polymeric nanoparticles with highly entrapped herbal hydrophilic drug using nanoprecipitation technique : An approach of quality by design
- 2015
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Ingår i: Pharmaceutical development and technology (Print). - : Informa UK Limited. - 1083-7450 .- 1097-9867. ; 20:5, s. 579-587
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Tidskriftsartikel (refereegranskat)abstract
- The intention of this study is to achieve higher entrapment efficiency (EE) of berberine chloride (selected hydrophilic drug) using nanoprecipitation technique. The solubility of drug was studied in various pH buffers (1.2-7.2) for selection of aqueous phase and stabilizer. Quality by design (QbD)-based 32 factorial design were employed for optimization of formulation variables; drug to polymer ratio (X1) and surfactant concentration (X2) on entrapment efficiency (EE), particle size (PS) and polydispersity index (PDI) of the nanoparticles. The nanoparticles were subjected to solid state analysis, in vitro drug release and stability study. The aqueous phase and stabilizer selected for the formulations were pH 4.5 phthalate buffer and surfactant F-68, respectively. The formulation (F-6) containing drug to polymer ratio (1:3) and stabilizer (F-68) concentration of 50mM exhibited best EE (82.12%), PS (196.71nm), PDI (0.153). The various solid state characterizations assured that entrapped drug is amorphous and nanoparticles are fairly spherical in shape. In vitro drug release of the F-6 exhibited sustained release with non-Fickian diffusion and stable at storage condition. This work illustrates that the proper selection of aqueous phase and optimization of formulation variables could be helpful in improving the EE of hydrophilic drugs by nanoprecipitation technique
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| 12. |
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| 13. |
- Sagar, Atish, et al.
(författare)
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Development of Smart Weighing Lysimeter for Measuring Evapotranspiration and Developing Crop Coefficient for Greenhouse Chrysanthemum
- 2022
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Ingår i: Sensors. - : MDPI. - 1424-8220. ; 22:16
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Tidskriftsartikel (refereegranskat)abstract
- The management of water resources is a priority problem in agriculture, especially in areas with a limited water supply. The determination of crop water requirements and crop coefficient (Kc) of agricultural crops helps to create an appropriate irrigation schedule for the effective management of irrigation water. A portable smart weighing lysimeter (1000 × 1000 mm and 600 mm depth) was developed at CPCT, IARI, New Delhi for real-time measurement of Crop Coefficient (Kc) and water requirement of chrysanthemum crop and bulk data storage. The paper discusses the assembly, structural and operational design of the portable smart weighting lysimeter. The performance characteristics of the developed lysimeter were evaluated under different load conditions. The Kc values of the chrysanthemum crop obtained from the lysimeter installed inside the greenhouse were Kc ini. 0.43 and 0.38, Kc mid-1.27 and 1.25, and Kc end-0.67 and 0.59 for the years 2019–2020 and 2020–2021, respectively, which apprehensively corroborated with the FAO 56 paper for determination of crop coefficient. The Kc values decreased progressively at the late-season stage because of the maturity and aging of the leaves. The lysimeter’s edge temperature was somewhat higher, whereas the center temperature closely matched the field temperature. The temperature difference between the center and the edge increased as the ambient temperature rose. The developed smart lysimeter system has unique applications due to its real-time measurement, portable attribute, and ability to produce accurate results for determining crop water use and crop coefficient for greenhouse chrysanthemum crops.
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| 14. |
- Singh, Amit K, et al.
(författare)
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Bovine Carbonyl Lactoperoxidase Structure at 2.0Å Resolution and Infrared Spectra as a Function of pH.
- 2012
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Ingår i: The protein journal. - : Springer Science and Business Media LLC. - 1875-8355 .- 1572-3887. ; 31:7, s. 598-608
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Tidskriftsartikel (refereegranskat)abstract
- Lactoperoxidase (LPO) is a hemeprotein catalyzing the oxidation of thiocyanate and I(-) into antimicrobials and small aromatic organics after being itself oxidized by H(2)O(2). LPO is excreted by the lungs, mammary glands, found in saliva and tears and protects mammals against bacterial, fungal and viral invasion. The Fe(II) form binds CO which inactivates LPO like many other hemeproteins. We present the 3-dimensional structure of CO-LPO at 2.0Å resolution and infrared (IR) spectra of the iron-bound CO stretch from pH 3 to 8.8 at 1 cm(-1) resolution. The observed Fe-C-O bond angle of 132° is more acute than the electronically related Fe(III), CN-LPO with a Fe-C-N angle of 161°. The orientations of the two ligands are different with the oxygen of CO pointing towards the imidazole of distal His109 while the nitrogen of CN points away, the Fe(II) moves towards His109 while the Fe(III) moves away; both movements are consistent with a hydrogen bond between the distal His109 and CO, but not to the nitrogen of CN-LPO. The IR spectra of CO-LPO exhibit two major CO absorbances with pH dependent relative intensities. Both crystallographic and IR data suggest proton donation to the CO oxygen by His109 with a pK ≈ 4; close to the pH of greatest enzyme turnover. The IR absorbance maxima are consistent with a first order correlation between frequency and Fe(III)/Fe(II) reduction potential at pH 7; both band widths at half-height correlate with electron density donation from Fe(II) to CO as gauged by the reduction potential.
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| 15. |
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| 16. |
- Bhojani, Amit K., et al.
(författare)
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Carbon-based monochalcogenides for efficient solar and heat energy harvesting
- 2023
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Ingår i: Applied Surface Science. - : Elsevier. - 0169-4332 .- 1873-5584. ; 608
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Tidskriftsartikel (refereegranskat)abstract
- A new generation of two-dimensional (2D) material has captivated significant attention in the energy conversion field owing to their promising optoelectronics and thermoelectric applications. The present work involves the systematic investigation of fundamental properties of single-layered 2D carbon-based monochalcogenides (CS, CSe, CTe) with planar, buckled and puckered geometry within the framework of density functional theory (DFT). The structural and lattice dynamics analysis disclose that puckered and buckled configurations are energetically and dynamically stable whereas planar structures depict instability. The anisotropic group velocity of longitu-dinal acoustic (LA) and transverse acoustic (TA) phonon modes in puckered systems may render the charac-teristics thermal transport properties. Additionally, for the first time, we scrutinized the thermoelectric and optical properties of these materials. At room temperature, the electron carrier mobilities are 174.698 and 160.830 m(2)V(-1)s(-1) of puckered and buckled CS systems, respectively are highest among all structures. The computed Seebeck coefficient, electrical conductivity and power factor manifests the high thermoelectric transport properties of puckered CS material. Further, the calculated solar parameters demonstrate an excep-tionally high-power conversion efficiency of 19.61 % for puckered CTe. Present work indicates that puckered phase of CS and CTe show their potential for the heat and solar energy harvesting devices, respectively.
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| 17. |
- Budhathoki, Shyam Sundar, et al.
(författare)
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The Association of Childhood Pneumonia with Household Air Pollution in Nepal: Evidence from Nepal Demographic Health Surveys.
- 2020
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Ingår i: Maternal and child health journal. - : Springer Science and Business Media LLC. - 1573-6628 .- 1092-7875. ; 24:Suppl 1, s. 48-56
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Tidskriftsartikel (refereegranskat)abstract
- Childhood pneumonia is a major cause of mortality worldwide while household air pollution (HAP) is a major contributor to childhood pneumonia in low and middle-income countries. This paper presents the prevalence trend of childhood pneumonia in Nepal and assesses its association with household air pollution.The study analysed data from the 2006, 2011 and 2016 Nepal Demographic Health Surveys (NDHS). It calculated the prevalence of childhood pneumonia and the factors that cause household air pollution. The association of childhood pneumonia and HAP was assessed using univariate and multi-variate analysis. The population attributable fraction (PAF) of indoor pollution for causing pneumonia was calculated using 2016 NDHS data to assess the burden of pneumonia attributable to HAP factors.The prevalence of childhood pneumonia decreased in Nepal between 2006 and 2016 and was higher among households using polluting cooking fuels. There was a higher risk of childhood pneumonia among children who lived in households with no separate kitchens in 2011 [Adjusted risk ratio (ARR) 1.40, 95% CI 1.01-1.97] and in 2016 (ARR 1.93, 95% CI 1.14-3.28). In 2016, the risk of children contracting pneumonia in households using polluting fuels was double (ARR 1.98, 95% CI 1.01-3.92) that of children from households using clean fuels. Based on the 2016 data, the PAF for pneumonia was calculated as 30.9% for not having a separate kitchen room and 39.8% for using polluting cooking fuel.Although the occurrence of childhood pneumonia in Nepal has decreased, the level of its association with HAP remained high.
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| 18. |
- Burstein, R., et al.
(författare)
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Mapping 123 million neonatal, infant and child deaths between 2000 and 2017
- 2019
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Ingår i: Nature. - : Nature Publishing Group. - 0028-0836 .- 1476-4687. ; 574:7778, s. 353-358
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Tidskriftsartikel (refereegranskat)abstract
- Since 2000, many countries have achieved considerable success in improving child survival, but localized progress remains unclear. To inform efforts towards United Nations Sustainable Development Goal 3.2—to end preventable child deaths by 2030—we need consistently estimated data at the subnational level regarding child mortality rates and trends. Here we quantified, for the period 2000–2017, the subnational variation in mortality rates and number of deaths of neonates, infants and children under 5 years of age within 99 low- and middle-income countries using a geostatistical survival model. We estimated that 32% of children under 5 in these countries lived in districts that had attained rates of 25 or fewer child deaths per 1,000 live births by 2017, and that 58% of child deaths between 2000 and 2017 in these countries could have been averted in the absence of geographical inequality. This study enables the identification of high-mortality clusters, patterns of progress and geographical inequalities to inform appropriate investments and implementations that will help to improve the health of all populations. © 2019, The Author(s).
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| 19. |
- Cao, Bin, et al.
(författare)
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Multiobjective Evolution of the Explainable Fuzzy Rough Neural Network With Gene Expression Programming
- 2022
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Ingår i: IEEE transactions on fuzzy systems. - : Institute of Electrical and Electronics Engineers (IEEE). - 1063-6706 .- 1941-0034. ; 30:10, s. 4190-4200
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Tidskriftsartikel (refereegranskat)abstract
- The fuzzy logic-based neural network usually forms fuzzy rules via multiplying the input membership degrees, which lacks expressiveness and flexibility. In this article, a novel neural network model is designed by integrating the gene expression programming into the interval type-2 fuzzy rough neural network, aiming to generate fuzzy rules with more expressiveness utilizing various logical operators. The network training is regarded as a multiobjective optimization problem through simultaneously considering network precision, explainability, and generalization. Specifically, the network complexity can be minimized to generate concise and few fuzzy rules for improving the network explainability. Inspired by the extreme learning machine and the broad learning system, an enhanced distributed parallel multiobjective evolutionary algorithm is proposed. This evolutionary algorithm can flexibly explore the forms of fuzzy rules, and the weight refinement of the final layer can significantly improve precision and convergence by solving the pseudoinverse. Experimental results show that the proposed multiobjective evolutionary network framework is superior in both effectiveness and explainability.
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| 20. |
- Fang, Bo, et al.
(författare)
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Dual-Channel Neural Network for Atrial Fibrillation Detection From a Single Lead ECG Wave
- 2023
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Ingår i: IEEE journal of biomedical and health informatics. - : Institute of Electrical and Electronics Engineers (IEEE). - 2168-2194 .- 2168-2208. ; 27:5, s. 2296-2305
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Tidskriftsartikel (refereegranskat)abstract
- With the dramatic progress of wearable devices, continuous collection of single lead ECG wave is able to be implemented in a comfortable fashion. Data mining on single lead ECG wave is therefore attracting increasing attention, where atrial fibrillation (AF) detection is a hot topic. In this paper, we propose a dual-channel neural network for AF detection from a single lead ECG wave. Two primary phases are included, the data preprocessing part followed by a dual-channel neural network. A two-stage denoising procedure is developed for data preprocessing, so as to tackle the high noise and disturbance which generally resides in the ECG wave collected by wearable devices. Then the time-frequency spectrum and Poincare plot of the denoised ECG signal are imported into the developed dual-channel neural network for feature extraction and AF detection. On the 2017 PhysioNet/CinC Challenge database, the F1 values were 0.83, 0.90, and 0.75 for AF rhythm and normal rhythm, and other rhythm, respectively. The results well validate the effectiveness of the proposed method for AF detection from a single lead ECG wave, and also indicate its performance advantages over some state-of-the-art counterparts.
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| 21. |
- Hjort, Martin, et al.
(författare)
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In situ assembly of bioresorbable organic bioelectronics in the brain
- 2023
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Ingår i: Nature Communications. - 2041-1723. ; 14:1
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Tidskriftsartikel (refereegranskat)abstract
- Bioelectronics can potentially complement classical therapies in nonchronic treatments, such as immunotherapy and cancer. In addition to functionality, minimally invasive implantation methods and bioresorbable materials are central to nonchronic treatments. The latter avoids the need for surgical removal after disease relief. Self-organizing substrate-free organic electrodes meet these criteria and integrate seamlessly into dynamic biological systems in ways difficult for classical rigid solid-state electronics. Here we place bioresorbable electrodes with a brain-matched shear modulus-made from water-dispersed nanoparticles in the brain-in the targeted area using a capillary thinner than a human hair. Thereafter, we show that an optional auxiliary module grows dendrites from the installed conductive structure to seamlessly embed neurons and modify the electrode's volume properties. We demonstrate that these soft electrodes set off a controlled cellular response in the brain when relaying external stimuli and that the biocompatible materials show no tissue damage after bioresorption. These findings encourage further investigation of temporary organic bioelectronics for nonchronic treatments assembled in vivo. Temporary bioelectronics can complement classical therapies in non-chronic treatments. Here, the authors describe the minimally invasive implantation of bioresorbable electrodes in the brain that form in situ from water-dispersed nanoparticles and show no tissue damage after bioresorption.
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| 22. |
- Kaur, Kuljeet, et al.
(författare)
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A Novel Resource Reservation Scheme for Mobile PHEVs in V2G Environment using Game Theoretical Approach
- 2015
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Ingår i: IEEE Transactions on Vehicular Technology. - Piscataway, NJ : IEEE Press. - 0018-9545 .- 1939-9359. ; 64:12, s. 5653-5666
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Tidskriftsartikel (refereegranskat)abstract
- With the widespread penetration of plug-in hybrid electric vehicles (PHEVs), the overall demand on micro-grids (MGs) may increase manifold in the near future. Unregulated power demands from PHEVs may increase the demand-supply gap at MG. Thus, in order to keep MGs stabilize, and cater the ever growing energy demands, there is a requirement of an intelligent solution to regulate, and manage PHEVs in vehicle-togrid (V2G) environment. Keeping in view the above issues, this paper proposes a novel scheme which aims to regulate PHEVs? charging, and discharging activities based on MGs? day-ahead load curves. These load curves are obtained by utilizing the existing load forecasting techniques such as-fuzzy logic (FL), and artificial neural networks (ANN). Efficient utilization of PHEVs according to these curves may play a vital role in flattening MG?s load profile. Thus, the proposed scheme works by reserving resources such as-time slots, and charging points for PHEVs during peak shaving, and valley filling. Different algorithms pertaining to resource reservation for PHEVs have also been designed. These algorithms employ the concepts of game theory, and 0/1 knapsack problem for supporting peak shaving, and valley filling respectively. Moreover, PHEVs are also utilized when there are transitions from valley filling to peak shaving areas in the load curves, and vice-versa. PHEVs involved in this process have both charging, and discharging capabilities, and are referred as dual-mode PHEVs. The proposed scheme has been tested with respect to various parameters, and its performance was found satisfactory. © 2015 IEEE
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| 23. |
- Khan, Ziyauddin, et al.
(författare)
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VO2 Nanostructures for Batteries and Supercapacitors: A Review
- 2021
-
Ingår i: Small. - : WILEY-V C H VERLAG GMBH. - 1613-6810 .- 1613-6829. ; 17
-
Forskningsöversikt (refereegranskat)abstract
- Vanadium dioxide (VO2) received tremendous interest lately due to its unique structural, electronic, and optoelectronic properties. VO2 has been extensively used in electrochromic displays and memristors and its VO2 (B) polymorph is extensively utilized as electrode material in energy storage applications. More studies are focused on VO2 (B) nanostructures which displayed different energy storage behavior than the bulk VO2. The present review provides a systematic overview of the progress in VO2 nanostructures syntheses and its application in energy storage devices. Herein, a general introduction, discussion about crystal structure, and syntheses of a variety of nanostructures such as nanowires, nanorods, nanobelts, nanotubes, carambola shaped, etc. are summarized. The energy storage application of VO2 nanostructure and its composites are also described in detail and categorically, e.g. Li-ion battery, Na-ion battery, and supercapacitors. The current status and challenges associated with VO2 nanostructures are reported. Finally, light has been shed for the overall performance improvement of VO2 nanostructure as potential electrode material for future application.
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| 24. |
- Kinnvall, Catarina, et al.
(författare)
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Enforcing and Resisting Hindutva : Popular Culture, the COVID-19 Crisis and Fantasy Narratives of Motherhood and Pseudoscience in India
- 2022
-
Ingår i: Social Sciences. - : MDPI AG. - 2076-0760. ; 11:12
-
Tidskriftsartikel (refereegranskat)abstract
- This article analyzes how Hindu nationalists employ fantasy narratives to counteract resistance, with a particular focus on narratives of ‘motherhood’ and ‘pseudoscience’. It does so by first introducing a conceptual discussion of the relationship between fantasy narratives, ontological insecurity, gender, and anti-science as a more general interrelationship characterizing pre- and post-COVID-19 far-right societies and leaders, such as India. It then moves on to discuss such fantasy narratives in the case of India by highlighting how this has played out in two cases of Hindu nationalist imaginings: that of popular culture, with a specific focus on the town Varanasi and the film Water (produced in 2000), and that of the COVID-19 pandemic and the emerging crisis and resistance that it has entailed. Extracts of interviews are included to illustrate this resistance.
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| 25. |
- Konda, Srinivasa Rao, et al.
(författare)
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Influence of embedded NiO-nanoparticles on the nonlinear absorption of tungsten disulfide nanolayers
- 2023
-
Ingår i: Optical materials (Amsterdam). - : Elsevier. - 0925-3467 .- 1873-1252. ; 138
-
Tidskriftsartikel (refereegranskat)abstract
- 2D transition metal dichalcogenides possess fascinating properties due to their direct bandgap, strong spin-orbit coupling, and promising electronic/mechanical properties. In this work, we synthesized pure tungsten disulfide (WS2) nanolayers and NiO nanoparticles (NPs) decorated in few-layered WS2 and measured the third-order nonlinear optical properties using femtosecond Z-scan measurements. The open aperture Z-scan data illustrated that the inclusion of NiO nanoparticles into the WS2 layers increases the nonlinear absorption at 800 and 400 nm wavelengths. Furthermore, we observed the switchability of the nonlinear absorption from saturable absorption to two-photon absorption or reverse saturable absorption by changing the pump intensity. Thus, the embedded NiO NPs played a crucial role in the variation of intensity-dependent nonlinear absorption mechanism of WS2 nanolayers and thus can be helpful for various optical applications such as laser pulse compression and optical limiting to prevent over-exposure of protective photosensitive sensors by intense ultrashort laser pulses.
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| 26. |
- Kåredal, Johan, et al.
(författare)
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Characterization of a computer board-to-board ultra-wideband channel
- 2007
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Ingår i: IEEE Communications Letters. - 1089-7798. ; 11:6, s. 468-470
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Tidskriftsartikel (refereegranskat)abstract
- In this paper we present the results of an extensive ultra-wideband (UWB) measurement campaign performed inside the chassis of two desktop computers. The purpose of the campaign is to analyze the possibility of board-to-board communications, replacing cable connections. Measurements of the propagation channel are performed over a frequency range of 3.1 - 10.6 GHz using a vector network analyzer and antennas small enough to enable integration on a circuit board. The results show that the propagation environment is very uniform, with small variations in the path gain between different positions within a computer. We also performed interference measurements, showing that the interference is restricted to certain subbands.
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| 27. |
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| 28. |
- Lv, Zhihan, Dr. 1984-, et al.
(författare)
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Computational Intelligence in Security of Digital Twins Big Graphic Data in Cyber-physical Systems of Smart Cities
- 2022
-
Ingår i: ACM TRANSACTIONS ON MANAGEMENT INFORMATION SYSTEMS. - : Association for Computing Machinery (ACM). - 2158-656X .- 2158-6578. ; 13:4
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Tidskriftsartikel (refereegranskat)abstract
- This investigation focuses on the application of computational intelligence to the security of Digital Twins (DTs) graphic data of the Cyber-physical System (CPS). The intricate and diverse physical space of CPS in the smart city is mapped in virtual space to construct the DTs CPS in the smart city. Besides, Differential Privacy Frequent Subgraph-Big Multigraph (DPFS-BM) is employed to ensure data privacy security. Moreover, the analysis and prediction model for the DTs big graphic data (BGD) in the CPS is built based on Differential Privacy-AlexNet (DP-AlexNet). Alexnet successfully solves the gradient dispersion problem of the Sigmoid function of deep network structures. Finally, the comparative analysis approach is utilized to verify the performance of the model reported here by comparing it with Long Short-Term Memory, Convolutional Neural Network, Recurrent Neural Network, original AlexNet, and Multi-Layer Perceptron in a simulation experiment. Through the comparison in the root mean square error, the mean absolute error, the mean absolute percentage error, training time, and test time, the model proposed here outperforms other models regarding errors, time delay, and time consumption. In the same environment, the system performs better with multi-hop paths, extra relays, and a high fading index; in that case, the outage probability is minimal. Therefore, the DP-AlexNet model is suitable for processing BGD. Moreover, its speed acceleration is more apparent than that of other models, with a higher SpeedUp indicator. The research effectively combines data mining and data security, which is of significant value for optimizing the privacy protection technology of frequent subgraph mining on a single multi-graph. Besides, the constructed DTs of CPS can provide excellent accuracy and a prominent acceleration effect on the premise of low errors. In addition, the model reported here can provide reference for the intelligent and digital development of smart cities.
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| 29. |
- Lv, Zhihan, Dr. 1984-, et al.
(författare)
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Digital Twins Based VR Simulation for Accident Prevention of Intelligent Vehicle
- 2022
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Ingår i: IEEE Transactions on Vehicular Technology. - : Institute of Electrical and Electronics Engineers (IEEE). - 0018-9545 .- 1939-9359. ; 71:4, s. 3414-3428
-
Tidskriftsartikel (refereegranskat)abstract
- This work aims to prevent Traffic Accident (TA) and ensure drivers' and pedestrians' life and property safety. A TA prevention and prediction system is established based on Digital Twins (DTs) and Artificial Intelligence (AI). Firstly, the double-scale decomposition equation decomposes the original TA Time Series Data (TSD) into multiple sub-layers. The Long-Short Term Memory (LSTM) network is used to predict the low-frequency sub-layers. Then, the double-scale LSTM network prediction model is constructed based on the prediction results. Secondly, a Particle Filter (PF) is proposed based on target block tracking and improved resampling against the possible occlusion problem in target tracking. The proposed PF can improve particle dilution. Finally, the proposed target tracking algorithm and DTs are combined and applied to TA processing, and a motor vehicle road TA-oriented video analysis system is designed. Then, the proposed system is tested. The results corroborate that the proposed research model can effectively predict the TSD of TA compared with other models and has strong robustness. Compared with the original LSTM model and Stacked Auto Encoders (SAEs) prediction model, the prediction accuracy of the proposed model is improved by 6% and 8%, respectively. Besides, the training and prediction time of the proposed model is less than the original LSTM and SAEs models. The optimized Particle Swarm Optimization (PSO) model makes the target identification easier. Additionally, the proposed model has good generalization performance. In short, the proposed system can effectively improve the efficiency of TA handling and ensure accuracy and fairness, which provides some data support for applying DTs in intelligent transportation.
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| 30. |
- Lv, Zhihan, Dr. 1984-, et al.
(författare)
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Transfer Learning-powered Resource Optimization for Green Computing in 5G-Aided Industrial Internet of Things
- 2022
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Ingår i: ACM Transactions on Internet Technology. - : Association for Computing Machinery (ACM). - 1533-5399 .- 1557-6051. ; 22:2
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Tidskriftsartikel (refereegranskat)abstract
- Objective: Green computing meets the needs of a low-carbon society and it is an important aspect of promoting social sustainable development and technological progress. In the investigation, green computing for resource management and allocation issues is only discussed. Therefore, in the context of the 5G communication network, the investigation of the data classification and resource optimization of the Internet of Things are conducted. Method: The virtualization architecture of the heterogeneous wireless network resource based on 5G technology is designed. The related investigation is conducted based on 5G network and Internet of Things technology. Under the traditional method, the transfer learning is introduced to improve the AdaBoost (Adaptive Boosting) algorithm to classify the data. The investigated complete resource reuse method is used to optimize resources. A method that a sub-channel can be reused by a cellular link and any number of D2D links at the same time is proposed to conduct resource optimization investigation. Results: The investigation indicates that the classification accuracy of the algorithm is excellent for the data classification of the Internet of Things and has different advantages in various aspects compared with other algorithms. The designed algorithm can find a larger set of resource reuse and have a significant increase in spectrum utilization efficiency. Conclusion: The investigation can contribute to the boom in the Internet of Things in terms of data classification and resource optimization based on 5G.
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| 31. |
- Marattukalam, Jithin James, et al.
(författare)
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Microstructure and corrosion behavior of laser processed NiTi alloy
- 2015
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Ingår i: Materials science & engineering. C, biomimetic materials, sensors and systems. - : Elsevier BV. - 0928-4931 .- 1873-0191. ; 57, s. 309-313
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Tidskriftsartikel (refereegranskat)abstract
- Laser Engineered Net Shaping (LENS™), a commercially available additive manufacturing technology, has been used to fabricate dense equiatomic NiTi alloy components. The primary aim of this work is to study the effect of laser power and scan speed on microstructure, phase constituents, hardness and corrosion behavior of laser processed NiTi alloy. The results showed retention of large amount of high-temperature austenite phase at room temperature due to high cooling rates associated with laser processing. The high amount of austenite in these samples increased the hardness. The grain size and corrosion resistance were found to increase with laser power. The surface energy of NiTi alloy, calculated using contact angles, decreased from 61 mN/m to 56 mN/m with increase in laser energy density from 20 J/mm2 to 80 J/mm2. The decrease in surface energy shifted the corrosion potentials to nobler direction and decreased the corrosion current. Under present experimental conditions the laser power found to have strong influence on microstructure, phase constituents and corrosion resistance of NiTi alloy.
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| 32. |
- Mishra, Amit, et al.
(författare)
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Intestinal Lymphatic Delivery of Praziquantel by Solid Lipid Nanoparticles: Formulation Design, In Vitro and In Vivo Studies
- 2014
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Ingår i: Hans Journal of Nanotechnology. - : Hindawi Limited. - 2161-086X .- 2161-0878 .- 1687-9503 .- 1687-9511. ; 2014
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Tidskriftsartikel (refereegranskat)abstract
- The aim of the present work was to design and develop Praziquantal (PZQ) loaded solid lipid nanoparticles (PZQ-SLN) to improve the oral bioavailability by targeting intestinal lymphatic system. PZQ is practically insoluble in water and exhibits extensive hepatic first-pass metabolism. PZQ SLN were composed of triglycerides, lecithin and various aqueous surfactants; were optimized using hot homogenization followed by ultrasonication method. The optimized SLN had particle size of 123 ± 3.41 nm, EE of 86.6 ± 5.72 %. The drug release of PZQ-SLN showed initial burst release followed by the sustained release. Inspite of zeta potential being around -10 mV, the optimized SLN were stable at storage conditions (5 ± 3 °C and 25 ± 2°C/ 60 ± 5 % RH) for six months. TEM study confirmed the almost spherical shape similar to the control formulations. Solid state characterization using differential scanning calorimeter (DSC) and powder X-ray diffraction (PXRD) analysis confirmed the homogeneous distribution of PZQ within the lipid matrix. The 5.81-fold increase in AUC 0 → ∞, after intraduodenal administration of PZQ-SLN in rats treated with saline in comparison to rats treated with cycloheximide (a blocker of intestinal lymphatic pathway), confirmed its intestinal lymphatic delivery. The experimental results indicate that SLN may offer a promising strategy for improving the therapeutic efficacy and reducing the dose.
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| 33. |
- Pandey, Rampal, et al.
(författare)
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Strong luminescence behavior of mono- and dimeric imidazoquinazolines: Swift OLED degradation under electrical current
- 2017
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Ingår i: Journal of Luminescence. - : ELSEVIER SCIENCE BV. - 0022-2313 .- 1872-7883. ; 181, s. 252-260
-
Tidskriftsartikel (refereegranskat)abstract
- Design and synthesis of novel mono-and dimeric quinazoline derivatives (+)-6-methyl-6-pyridin-2-yl-5,6-dihydrobenzo[4,5]imidazo[1,2-c]quinazoline (1) and (+)-6-[(6-methyl-5,6-dihydrobenzo-[4,5]imidazo [1,2-c] quinazolin-6-yl)-pyridin-2-yl]-6-methyl-5,6-dihydro-benzo-[4,5]imidazo-[1,2-c] quinazoline (2) have been described. Both 1 and 2 have been characterized by elemental analyses, FT-IR, H-1 and C-13 NMR, HRMS spectroscopic studies and their structures authenticated by X-ray single crystal analyses. Photophysical properties of these compounds have been studied by UV/VIS absorption and fluorescence spectroscopy and transient photoluminescence analysis in solution, powder, and non-doped (neat) and doped vacuum-deposited films. A broad emission spectrum spanning most of the visible range and good thermal stability indicated promising application of 1 and 2 as OLED emitters. Unfortunately, under current flow we observed rapid device degradation, presumably to be related to free -NH moiety in these compounds. (C) 2016 Elsevier B.V. All rights reserved.
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| 34. |
- Perween, Shama, et al.
(författare)
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PVA-PDMS-Stearic acid composite nanofibrous mats with improved mechanical behavior for selective filtering applications
- 2018
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Ingår i: Scientific Reports. - : NATURE PUBLISHING GROUP. - 2045-2322. ; 8
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Tidskriftsartikel (refereegranskat)abstract
- In this work, we report a facile way to fabricate composite nanofibrous mats of polyvinyl alcohol (PVA), polydimethylsiloxane (PDMS), and stearic acid (SA) by employing the electrospinning-technique, with PDMS fraction ranging from 40w% to nearly 80w%. The results show that for a predetermined fraction of PVA and SA, incorporation of an optimal amount of PDMS is necessary for which the mats exhibit the best mechanical behavior. Beyond this optimal PDMS fraction, the mechanical properties of the composite mats deteriorate. This result has been attributed to the ability of the SA molecules to mediate binding between the PVA and PDMS long-chain molecules via van-der-Waals bonding. The morphological, structural, mechanical, and thermal characterizations respectively using SEM, XRD, DMA/tensile test, and DSC lend support to this explanation. By this method, it is possible to control the hydrophilicity/oleophilicity of the mats, and the mats show an excellent selective permeability to oil as compared to water and successfully filter water from a water-in-oil emulsion. Incorporation of SA not only serves to aid in electrospinning of a PDMS-rich nanofibrous mat with good mechanical strength and control over hydrophilicity/oleophilicity, but also has a potential use in fabricating sheets impregnated with phase change materials for thermal energy storage.
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| 35. |
- Qiao, Sibo, et al.
(författare)
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A Pseudo-Siamese Feature Fusion Generative Adversarial Network for Synthesizing High-quality Fetal Four-chamber Views
- 2023
-
Ingår i: IEEE journal of biomedical and health informatics. - : Institute of Electrical and Electronics Engineers (IEEE). - 2168-2194 .- 2168-2208. ; 27:3, s. 1193-1204
-
Tidskriftsartikel (refereegranskat)abstract
- Four-chamber (FC) views are the primary ultrasound (US) images that cardiologists diagnose whether the fetus has congenital heart disease (CHD) in prenatal diagnosis and screening. FC views intuitively depict the developmental morphology of the fetal heart. Early diagnosis of fetal CHD has always been the focus and difficulty of prenatal screening. Furthermore, deep learning technology has achieved great success in medical image analysis. Hence, applying deep learning technology in the early screening of fetal CHD helps improve diagnostic accuracy. However, the lack of large-scale and high-quality fetal FC views brings incredible difficulties to deep learning models or cardiologists. Hence, we propose a Pseudo-Siamese Feature Fusion Generative Adversarial Network (PSFFGAN), synthesizing high-quality fetal FC views using FC sketch images. In addition, we propose a novel Triplet Generative Adversarial Loss Function (TGALF), which optimizes PSFFGAN to fully extract the cardiac anatomical structure information provided by FC sketch images to synthesize the corresponding fetal FC views with speckle noises, artifacts, and other ultrasonic characteristics. The experimental results show that the fetal FC views synthesized by our proposed PSFFGAN have the best objective evaluation values: SSIM of 0.4627, MS-SSIM of 0.6224, and FID of 83.92, respectively. More importantly, two professional cardiologists evaluate healthy FC views and CHD FC views synthesized by our PSFFGAN, giving a subjective score that the average qualified rate is 82% and 79%, respectively, which further proves the effectiveness of the PSFFGAN.
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| 36. |
- Rawal, Amit, et al.
(författare)
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Ultrasonic fortification of interfiber autohesive contacts in meltblown nonwoven materials
- 2024
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Ingår i: Journal of Advanced Joining Processes. - 2666-3309. ; 9
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Tidskriftsartikel (refereegranskat)abstract
- Autohesion is a unique class of adhesion that enables the bonding of two identical surfaces by establishing intimate contact at interfaces. Creating intimacy between two identical surfaces poses a challenging task, often constrained by the presence of surface roughness and chemical heterogeneity. To surmount this challenge, we document a variety of autohesive traits in polypropylene-based meltblown nonwovens, accomplished through a facile, scalable, energy-efficient, and cost-effective ultrasonic bonding process. The mean work of autohesion for a single polypropylene bond, serving as a figure of merit, has been computed by extending the classical Johnson−Kendall−Roberts (JKR) theory by factoring in peel strength along with key fiber and structural parameters of nonwoven materials. Achieving a high figure of merit in ultrasonically bonded nonwovens hinges on the synergistic interplay of key process parameters, including static force, power, and welding speed, with the fiber and structural properties acting in concert. In this regard, peel-off force analysis has also been conducted on a series of twenty-seven ultrasonically bonded meltblown nonwovens prepared using a 33 full factorial design by systematically varying process parameters (static force, power, and welding speed) across three levels and extension rate. X-ray microcomputed tomography (microCT) analysis has been performed on select ultrasonically bonded nonwoven samples to discern their bulk characteristics. A broad spectrum of mean work of autohesion for a single polypropylene bond, ranging from 1.88 to 9.93 J/m², has been ascertained by modulating key process parameters.
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| 37. |
- Sbarra, AN, et al.
(författare)
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Mapping routine measles vaccination in low- and middle-income countries
- 2021
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 589:7842, s. 415-
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Tidskriftsartikel (refereegranskat)abstract
- The safe, highly effective measles vaccine has been recommended globally since 1974, yet in 2017 there were more than 17 million cases of measles and 83,400 deaths in children under 5 years old, and more than 99% of both occurred in low- and middle-income countries (LMICs)1–4. Globally comparable, annual, local estimates of routine first-dose measles-containing vaccine (MCV1) coverage are critical for understanding geographically precise immunity patterns, progress towards the targets of the Global Vaccine Action Plan (GVAP), and high-risk areas amid disruptions to vaccination programmes caused by coronavirus disease 2019 (COVID-19)5–8. Here we generated annual estimates of routine childhood MCV1 coverage at 5 × 5-km2pixel and second administrative levels from 2000 to 2019 in 101 LMICs, quantified geographical inequality and assessed vaccination status by geographical remoteness. After widespread MCV1 gains from 2000 to 2010, coverage regressed in more than half of the districts between 2010 and 2019, leaving many LMICs far from the GVAP goal of 80% coverage in all districts by 2019. MCV1 coverage was lower in rural than in urban locations, although a larger proportion of unvaccinated children overall lived in urban locations; strategies to provide essential vaccination services should address both geographical contexts. These results provide a tool for decision-makers to strengthen routine MCV1 immunization programmes and provide equitable disease protection for all children.
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| 38. |
- Singh, Munindar P., et al.
(författare)
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The Uses of Norms
- 2013
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Ingår i: Normative Multi-Agent Systems. - Dagstuhl : Schloss Dagstuhl--Leibniz-Zentrum fuer Informatik. - 9783939897514 ; , s. 191-229
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 39. |
- Singh, Prashant, et al.
(författare)
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A review on biochar composites for soil remediation applications : Comprehensive solution to contemporary challenges
- 2023
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Ingår i: Journal of Environmental Chemical Engineering. - : Elsevier BV. - 2213-3437. ; 11:5
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Forskningsöversikt (refereegranskat)abstract
- Biochar has emerged as a promising material for solving many environmental challenges. It's derived from biomass pyrolysis and acts as a carbon shuttle between the atmosphere and soil. It also serves as a fertility agent and can remove contaminants from soil. This review aims to understand the effect of the choice of preparation methods and process parameters like temperature, feedstock, and additives on the characteristics of biochar. A detailed investigation into how biochar modifications enhance biochar properties and stability has been provided. Mechanisms of biochar composite applications for remediation of contaminated soil, carbon sequestration, and soil fertility enhancement through analysis of relevant research studies have been presented. Further, an effort has been made to discuss and suggest possible optimization of biochar preparation to achieve multiple goals in soil collectively. Specifically, the role of adding metal compounds, minerals, and ions has been explored. Challenges and conflicting research findings have also been mentioned based on the available literature. This paper majorly focuses on the need to address contemporary challenges like climate change, soil toxicity, and fertility loss holistically and sustainably using biochar composite application in soil. Future research in this field must include biochar applications in temporal and spatial aspects for optimal use.
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| 40. |
- Singh, Prem, et al.
(författare)
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Cubic Palladium Nanorattles with Solid Octahedron Gold Core for Catalysis and Alkaline Membrane Fuel Cell Applications
- 2019
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Ingår i: ChemCatChem. - : WILEY-V C H VERLAG GMBH. - 1867-3880 .- 1867-3899. ; 11:17, s. 4383-4392
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Tidskriftsartikel (refereegranskat)abstract
- Herein, we report the synthesis of palladium nanorattles (Au-Pd NRTs) comprising of a gold octahedral core caged within a thin porous cubic palladium shell. The introduction of core-shell and porous architecture was realized by combining seed mediated and galvanic replacement reaction techniques. Next, we examined the catalytic efficiency of the nanocatalyst in comparison with solid palladium nanocube (Pd-NC) of similar size for the degradation of p-nitrophenol and organic dyes. The rate constant of Au-Pd NRTs was found nearly 12 times higher than the Pd-NCs. Further, we exploited our catalyst for electrochemical oxygen reduction reaction (ORR) and observed its high intrinsic ORR activity. Compared with commercialized Pt/C, the Au-Pd NRT displayed nearly comparable onset and half-wave potential values and excellent durability upon potential cycling. The system level validation in a single-cell mode of alkaline exchange membrane fuel cell also confirms the efficiency of the present catalyst to serve as a potential cathode catalyst for realistic device applications.
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| 41. |
- Singh, Ram, et al.
(författare)
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Impact of quarantine on fractional order dynamical model of Covid-19
- 2022
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Ingår i: Computers in Biology and Medicine. - Oxford : Elsevier. - 0010-4825 .- 1879-0534. ; 151, Part A
-
Tidskriftsartikel (refereegranskat)abstract
- In this paper, a Covid-19 dynamical transmission model of a coupled non-linear fractional differential equation in the Atangana-Baleanu Caputo sense is proposed. The basic dynamical transmission features of the proposed system are briefly discussed. The qualitative as well as quantitative results on the existence and uniqueness of the solutions are evaluated through the fixed point theorem. The Ulam-Hyers stability analysis of the suggested system is established. The two-step Adams-Bashforth-Moulton (ABM) numerical method is employed to find its numerical solution. The numerical simulation is performed to accesses the impact of various biological parameters on the dynamics of Covid-19 disease. © 2022 The Author(s). Published by Elsevier Ltd. All rights reserved.
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| 42. |
- Teng, Fei, et al.
(författare)
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Multimedia Monitoring System of Obstructive Sleep Apnea via Deep Active Learning Model
- 2022
-
Ingår i: IEEE Multimedia. - : IEEE. - 1070-986X .- 1941-0166. ; 29:3, s. 48-56
-
Tidskriftsartikel (refereegranskat)abstract
- Obstructive Sleep Apnea (OSA) is one of the most common sleep-related breathing disorders. Nearly 1 billion people worldwide suffer from it, causing serious health effects and social burden. However, traditional monitoring systems often fall short in terms of cost and accessibility. In this article, we first propose a deep active learning model to detect OSA events from electrocardiogram (ECG). We then designed and developed a prototype of OSA monitoring system using ECG sensor and smartphone, in which our OSA detection algorithm is implemented and validated. Experiments show that we achieve accuracy of 92.15% while using 40% of labeled data, significantly reducing the cost of labeling and maximizing the performance. According to detection results and health-related multimedia signals, we provide OSA risk level and medical advice to users. We believe that the multimedia monitoring system can efficiently help diagnose OSA, which could lead to effective intervention strategies and better sleep care.
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| 43. |
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| 44. |
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| 45. |
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| 46. |
- Yadav, Varnika, et al.
(författare)
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2D MoS2 -Based Nanomaterials for Therapeutic, Bioimaging, and Biosensing Applications
- 2019
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Ingår i: Small. - : Wiley. - 1613-6810 .- 1613-6829. ; 15:1
-
Tidskriftsartikel (refereegranskat)abstract
- Molybdenum disulfide (MoS2 ), a typical layered 2D transition metal dichalcogenide, has received colossal interest in the past few years due to its unique structural, physicochemical, optical, and biological properties. While MoS2 is mostly applied in traditional industries such as dry lubricants, intercalation agents, and negative electrode material in lithium-ion batteries, its 2D and 0D forms have led to diverse applications in sensing, catalysis, therapy, and imaging. Herein, a systematic overview of the progress that is made in the field of MoS2 research with an emphasis on its different biomedical applications is presented. This article provides a general discussion on the basic structure and property of MoS2 and gives a detailed description of its different morphologies that are synthesized so far, namely, nanosheets, nanotubes, and quantum dots along with synthesis strategies. The biomedical applications of MoS2 -based nanocomposites are also described in detail and categorically, such as in varied therapeutic and diagnostic modalities like drug delivery, gene delivery, phototherapy, combined therapy, bioimaging, theranostics, and biosensing. Finally, a brief commentary on the current challenges and limitations being faced is provided, along with a discussion of some future perspectives for the overall improvement of MoS2 -based nanocomposites as a potential nanomedicine.
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| 47. |
- Zhu, Meifang, et al.
(författare)
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Measurement based ray launching for analysis of outdoor propagation
- 2012
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Ingår i: 6th European Conference on Antennas and Propagation (EUCAP), 2012. - 9781457709180 ; , s. 3332-3336
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Konferensbidrag (refereegranskat)abstract
- Clustering is a key concept of existing MIMO channel models, such as the COST 2100 model. Parameter based clustering has been studied for a while, but how parameter based clusters relate to the physical environment is not well known yet. A measurement based ray launching tool is developed and used for studying clustering and its relation to physical scatterers. By using estimated angles and delays of multi-path components as input to the ray launching tool, the physical scatterers along the propagation paths are visualized. After the physical scatterers are grouped, we notice that when the receiver moves, some physical scatterers continue to contribute to the channel response while others disappear and sometimes also later re-appear as represented by the cluster life time and common clusters in the COST 2100 model. Our measurement based ray launching tool shows significant advantages for further channel analysis and modeling.
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