| 1. |
- Hedström, Brita, et al.
(författare)
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Visby Innerstad : En användningsplan
- 1973
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Rapport (populärvet., debatt m.m.)abstract
- Sedan lång tid föreligger i stort sett enighet om att bevara innerstadens bebyggelse och att anpassa eventuella nytillskott till det redan bestående. Med den inställningen har förändringsprocessen både dämpats och mildrats men ändå inte bragts att avstanna. Förändringar sker ständigt om det också huvudsakligen i smått: de många synbart så anspråkslösa byggnadsåtgärderna adderar efterhand ihop sig till något större och mer genomgripande. Långsamt, nästan omärkligt, ändrar innerstaden sitt ansikte.Ändå är det inte själva husen som förändrats mest utan användningen av dem. Ur funktionell synpunkt har 1950 - och 60-talen har varit något av en omstörtning i innerstadens historia: den har förlorat nästan hälften av de boende, en stor del av detaljhandeln och praktiskt taget helt sin gamla roll som skolcentrum. I gengäld har ytterstaden vuxit ut till ett sammanhängande kilometerbrett bälte. Till stor del av denna funktionella förändring en följd av beslutet att bevara innerstadens bebyggelse. Vad som inte fått plats inom den gamla ramen har etablerats utandör den.Föreliggande arbete vill ge en översiktlig bild av förändringsförloppen, sedda i ett långt tidsperspektiv men med tonvikt på dagsläget. Bebyggelsen tas upp till utförlig granskning men också användningen av den. Det är just samspelet mellan husen och de funtkioner, de fyller, som kan sägas utgöra bokens huvudtema. I de flesta fall är detta sammanhang hus-användning alldeles konfliktfritt och föranleder därför inte heller någon diskussion. Vad som behandlas är de relativt få problematiska fallen, hus som borde rustas upp för att fylla sin uppgift, hus som är olämpligt nyttjade eller inte använda alls. En serie sådana fall tas upp till systematisk genomgång; samtidigt berörs också de trafik - och miljömässiga konsekvenserna. Bokens syfte är alltså klart: den ger ett underlag av fakta för arbetet med att jämka samman byggnader och användningsformer. I den meningen kan skriften kallas en anvädningsplan för Visby innanför murarna.Arkitekturskolanas arbete har bedrivitis parallellt med den kommunala Innerstadskommitténs verksamhet. Något organiserat samarbete har inte förekommit med de informella kontakterna har varit både täta och goda. Att likheterna mellan Innerstadskommittén och Arkitekturskolans slutsatser blivit så pass stora, kan tillskrivas en gemensam helhetssyn.En av Arkitekturskolans elever, arkitekt Lars-Ingvar Larsson, har tidigare självständigt genomfört en undersökning av förändringar i innerstaden 1945-70- Denna studie publicerats separat och bör uppfattas som ett komplement till den hör föreliggande.Förutom de i innehållsförteckningen nämnda har ytterligare några aktivt medverkat i arbetet. Studiet av trafikfrågorna i innerstaden, i hamnen och öster om ringmuren leddes av Åke Claesson, I fältstudier och diskussioner medverkande Göran Månsson.Arkitekturskolan har fått god hjälp av ett antal initierade personer i Visby. Särskild tacksamhet är vi skyldiga byggnadsnämnden ordförande Henning Jacobson, kommunalrådet C B Stenström, stadsarkitekten Måns Hagbergm f. länsbostadsdorektören Åke Malmberg och landsantikvarien Gunnar Svahnström. I boken publiceringskostnaderna har ekonomiskt bidrag lämnats av Gotlands kommun och Riksantikvarieämbetet.Boken har redigerats av Sture Balgård och Ann Mari Westerlind med hjälp av Henrik O Andersson, Bo Ek, Göran Lindahl, Fredrik von Platen, John Sjöström Gunnar Westerlind och Hans Wetterfors.Skeppsholmen, Stockholm, sommaren 1973.Arkitekturskolans lärare och elever.
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| 2. |
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| 3. |
- Stoltz Sjöström, Elisabeth, et al.
(författare)
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Nutrient intakes independently affect growth in extremely preterm infants: results from a population-based study
- 2013
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Ingår i: Acta Paediatrica. - : Wiley-Blackwell. - 0803-5253 .- 1651-2227. ; 102:11, s. 1067-1074
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Tidskriftsartikel (refereegranskat)abstract
- AimTo explore associations between energy and macronutrient intakes and early growth in extremely low gestational age (ELGA) infants. less thanbrgreater than less thanbrgreater thanMethodsRetrospective population-based study of all ELGA infants (andlt;27weeks) born in Sweden during 2004-2007. Detailed data on nutrition and anthropometric measurements from birth to 70days of postnatal age were retrieved from hospital records. less thanbrgreater than less thanbrgreater thanResultsStudy infants (n=531) had a meanSD gestational age of 25.3 +/- 1.1weeks and a birth weight of 765 +/- 170g. Between 0 and 70days, average daily energy and protein intakes were 120 +/- 11kcal/kg and 3.2 +/- 0.4g/kg, respectively. During this period, standard deviation scores for weight, length and head circumference decreased by 1.4, 2.3 and 0.7, respectively. Taking gestational age, baseline anthropometrics and severity of illness into account, lower energy intake correlated with lower gain in weight (r=+0.315, pandlt;0.001), length (r=+0.215, pandlt;0.001) and head circumference (r=+0.218, pandlt;0.001). Protein intake predicted growth in all anthropometric outcomes, and fat intake was positively associated with head circumference growth. less thanbrgreater than less thanbrgreater thanConclusionExtremely low gestational age infants received considerably less energy and protein than recommended and showed postnatal growth failure. Nutrient intakes were independent predictors of growth even after adjusting for severity of illness. These findings suggest that optimized energy and macronutrient intakes may prevent early growth failure in these infants.
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| 4. |
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| 5. |
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| 6. |
- Zamir, Itay, et al.
(författare)
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Neonatal hyperglycaemia is associated with worse neurodevelopmental outcomes in extremely preterm infants
- 2021
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Ingår i: Archives of Disease in Childhood. - : BMJ Publishing Group Ltd. - 1359-2998 .- 1468-2052. ; 106:5, s. F460-F466
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To assess the associations between neonatal hyperglycaemia and insulin treatment, versus long-Term neurodevelopmental outcomes in children born extremely preterm.Design and setting: Observational national cohort study (Extremely Preterm Infants in Sweden Study) using prospectively and retrospectively collected data. Neurodevelopmental assessment was performed at 6.5 years of age.Patients: 533 infants born <27 gestational weeks during 2004-2007; 436 survivors were assessed at 6.5 years.Outcome measures: Neurodevelopmental disability (NDD), survival without moderate to severe NDD, Wechsler Intelligence Scale for Children IV Full scale intelligence quotient (WISC-IV FSIQ) and Movement Assessment Battery for Children 2 (MABC-2) total score.Results: Duration of neonatal hyperglycaemia >8 mmol/L was associated with WISC-IV scores-for each day with hyperglycaemia there was a decrease of 0.33 points (95% CI 0.03 to 0.62) in FSIQ. Neonatal hyperglycaemia >8 mmol/L occurring on 3 consecutive days was associated with lower MABC-2 scores (adjusted mean difference:-4.90; 95% CI-8.90 to-0.89). For each day with hyperglycaemia >8 mmol/L, there was a decrease of 0.55 points (95% CI 0.17 to 0.93) in MABC-2 total score. Insulin treatment was not associated with any of the outcome measures.Conclusion: Neonatal hyperglycaemia >8 mmol/L was associated with lower intelligence scores and worse motor outcomes at 6.5 years of age. Insulin treatment was not associated with either worsened or improved neurodevelopmental outcomes. Randomised controlled trials are needed to clarify the role of insulin in treating hyperglycaemia in extremely preterm infants.
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| 7. |
- Andersson, Jonas, et al.
(författare)
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Association of adipose tissue blood flow with fat depot sizes and adipokines in women
- 2012
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Ingår i: International Journal of Obesity. - : Nature Publishing Group. - 0307-0565 .- 1476-5497. ; 36:6, s. 783-789
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To explore possible associations between adipose tissue (AT) blood flow (ATBF), AT depot sizes and adipocyte-derived hormones (adipokines) in women.Subjects: In all, 43 healthy women were divided into four groups: normal-weight (n=11) and obese (n=11) pre-menopausal women and normal-weight (n=10) and obese (n=11) post-menopausal women.Methods: Fasting levels of adipokines were obtained, and a single-slice computed tomography scan at the level of L4-L5 was used to estimate fat depot sizes. ATBF was assessed by xenon washout while in a fasting state and after oral glucose load. We also measured glucose, insulin and non-esterified fatty acids.Results: Total, subcutaneous and visceral AT areas strongly correlated with ATBF (all P<0.001). Circulating leptin levels strongly and inversely correlated with ATBF (P=0.001), but this association did not remain after adjustment for body mass index. Adiponectin was not associated with blood flow.Conclusion: ATBF is closely linked to subcutaneous and visceral AT size. Further analyses are needed to determine possible mediators of this association, including mechanistic studies to assess a putative role for leptin as a significant modulator of blood flow. International Journal of Obesity advance online publication, 26 July 2011; doi:10.1038/ijo.2011.152.
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| 8. |
- Andersson, Jonas, et al.
(författare)
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Dysregulation of subcutaneous adipose tissue blood flow in overweight postmenopausal women
- 2010
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Ingår i: Menopause. - : Ovid Technologies (Wolters Kluwer Health). - 1072-3714 .- 1530-0374. ; 17:2, s. 365-371
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: A putative link between abdominal obesity and metabolic-vascular complications after menopause may be due to a decreased adipose tissue blood flow (ATBF). The present work aimed to analyze possible changes in ATBF with being overweight and menopausal and its putative link to endothelial dysfunction and autonomic nervous system balance.METHODS: Forty-three healthy women were classified into four groups according to weight and menopause status. The ATBF was measured by xenon washout while fasting and after oral glucose intake. The nitric oxide synthase inhibitor asymmetric dimethylarginine was used as a marker of endothelial function and heart rate variability-estimated autonomic nervous system activity.RESULTS: Fasting ATBF was decreased in both overweight groups (P = 0.044 and P = 0.048) versus normal-weight premenopausal women. Normal-weight and overweight postmenopausal women exhibited lower maximum ATBF compared with normal-weight premenopausal women (P = 0.015 and P = 0.001, respectively), and overweight postmenopausal women exhibited lower maximum ATBF compared with normal-weight postmenopausal women (P = 0.003). A negative correlation was found between fasting ATBF and asymmetric dimethylarginine (P = 0.015), whereas maximum ATBF was negatively associated with sympathetic-parasympathetic nervous system balance (ratio of the power of the low frequency to the power of the high frequency; P = 0.002).CONCLUSIONS: Loss of ATBF flexibility in overweight postmenopausal women may contribute to the metabolic dysfunction seen in this group of women.
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| 9. |
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| 10. |
- Andersson, Ulrika, et al.
(författare)
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A comprehensive study of the association between the EGFR and ERBB2 genes and glioma risk
- 2010
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Ingår i: Acta Oncologica. - : Informa Healthcare. - 0284-186X .- 1651-226X. ; 12, s. 17-17
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Tidskriftsartikel (refereegranskat)abstract
- Glioma is the most common type of adult brain tumor and glioblastoma, its most aggressive form, has a dismal prognosis. Receptor tyrosine kinases such as the epidermal growth factor receptor (EGFR, ERBB2, ERBB3, ERBB4) family, and the vascular endothelial growth factor receptor (VEGFR), play a central role in tumor progression. We investigated the genetic variants of EGFR, ERBB2, VEGFR and their ligands, EGF and VEGF on glioma and glioblastoma risk. In addition, we evaluated the association of genetic variants of a newly discovered family of genes known to interact with EGFR: LRIG2 and LRIG3 with glioma and glioblastoma risk. Methods. We analyzed 191 tag single nucleotide polymorphisms (SNPs) capturing all common genetic variation of EGF, EGFR, ERBB2, LRIG2, LRIG3, VEGF and VEGFR2 genes. Material from four case-control studies with 725 glioma patients (329 of who were glioblastoma patients) and their 1 610 controls was used. Haplotype analyses were conducted using SAS/Genetics software. Results. Fourteen of the SNPs were significantly associated with glioma risk at p< 0.05, and 17 of the SNPs were significantly associated with glioblastoma risk at p< 0.05. In addition, we found that one EGFR haplotype was related to increased glioblastoma risk at p=0.009, Odds Ratio [OR] = 1.67 (95% confidence interval (CI): 1.14, 2.45). The Bonferroni correction made all p-values non-significant. One SNP, rs4947986 next to the intron/exon boundary of exon 7 in EGFR, was validated in an independent data set of 713 glioblastoma and 2 236 controls, [OR] = 1.42 (95% CI: 1.06,1.91). Discussion. Previous studies show that regulation of the EGFR pathway plays a role in glioma progression but the present study is the first to find that certain genotypes of the EGFR gene may be related to glioblastoma risk. Further studies are required to reinvestigate these findings and evaluate the functional significance.
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| 11. |
- Bengtsson, Fredrik, et al.
(författare)
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Sustainability Impact of Open Innovation Software
- 2012
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Ingår i: Proceedings of the XXIII ISPIM Conference Action for Innovation: Innovating from Experience, Barcelona, Spain, 17-20 June 2012..
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Konferensbidrag (refereegranskat)
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| 12. |
- Brandon, Daniel, et al.
(författare)
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Fire Safe implementation of visible mass timber in tall buildings – compartment fire testing
- 2021
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Five real scale fire tests of compartments constructed of cross-laminated timber (CLT) and glued laminated timber, compliant with product standards specified in current US model building code, were performed. Four of the tested compartments were designed to result in a representative and severe fire scenario in a residential fire compartment, using a probabilistic approach. The other tested compartment had additional openings and a greater opening factor, which was aimed to be representative of buildings designed for business occupancy. The interior of the compartments had surface areas of exposed mass timber that varied from approximately the area of the floor plan to approximately two times the area of the floor plan. The tests included measurements to study the internal compartment exposure, the temperature development at gypsum protected surfaces, the temperature development in the structural timber, oxygen concentrations at locations of interest and exposure to exterior surfaces of the wall and façade above the openings. The fire in the compartment with a greater opening factor had two layers of fire-rated gypsum board protection on the back wall and all other surfaces of CLT and glued laminated timber exposed. Despite having the highest peak combustion rate, this compartment fire had the least severe internal and external fire exposure. The fire decayed relatively quickly after flashover and continued to decay until the test was stopped at 4 hours after ignition. This fire resulted in less structural damage than the fires in compartments with fewer and smaller openings. The compartments with fewer and smaller openings had similar temperatures for approximately the first 10 minutes after flashover. The compartment with only the ceiling (including the glued laminated timber beam) exposed started to decay after 22 minutes of post-flashover fire and continued to decay until the end of the test at 4 hours after ignition. The other three tests had, in addition to the ceiling, significant areas of exposed wall and column surfaces. To accommodate for the extended fire duration that was expected in these configurations an extra layer of gypsum board protection was applied to the protected surfaces. The additional exposed surface areas of walls led to an increase of the fully developed fire duration by 6 - 9 minutes. One of the compartments included corners where two exposed walls intersect. Significantly increased damage was observed in the lower part of these wall corners, and an overall higher radiative exposure in the test with such corners. After more than three hours of decay, surface flaming developed on the walls in that test. The fires in the tests without such corners exhibited continual decay for the full 4-hour test duration. Post-test analysis showed that the structural damage was lower in exposed ceilings than at the bottom of the exposed walls for all tests. After the tests, remaining smoldering and hot spots were reduced using relatively small amounts of water mist. Overnight measurements to study the thermal wave going through the loadbearing structure indicated no post-test reduction of structural capacity.
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| 13. |
- Brandon, Daniel, et al.
(författare)
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Fire Safety of CLT Buildings with Ex-posed Wooden Surfaces : Summary Report
- 2020
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Five real scale compartment fire tests, constructed of CLT slabs and glulam beam and column in accordance with current US product standards, were performed. The compartments had surface areas of exposed mass timber equal to up to two times the area of the floor plan. The 4 hours long tests showed that compartments with such quantities of exposed wood can exhibit continuous decay to hot-spots and embers after flashover. The tests indicate that the presence of two exposed wall surfaces in one corner should be avoided to ensure this.
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| 14. |
- Brandon, Daniel, et al.
(författare)
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Post-Fire Rehabilitation of CLT
- 2021
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Engineered mass timber materials such as CLT have been increasingly implemented as a structural material for tall or larger buildings in recent years. Most studies have been conducted on the structural performance of timber exposed to fire, but the number of studies focusing on post-fire rehabilitation of mass timber have been limited. As increasingly large timber buildings are being realized, for insurance purposes it becomes increasingly important to ensure that a building can be repaired after a fire. This report presents a case study of the repair of a section of a CLT ceiling after a significant fire. The specimen is obtained from a recent compartment fire test and is positioned and oriented in a way that is representative for on site rehabilitation. The repair was done in six steps: 1. Mapping the thickness of the charred or damaged layer 2. Design and planning 3. Removal of the char layer 4. Planing of the surface including corners 5. Gluing procedure of replacing lamella 6. Finish the surface to meet architectural requirement A new method for determining the grade of damage, the method for planing the specimen, the adhesive type, the glue pressing methods were designed for the rehabilitation exercise. In addition, the layup of the CLT is changed to prioritise flexural stiffness and bending capacity over shear capacity, as they generally govern the structural capacity of CLT floors. After the six-step repair was done, the specimen was cut in half to perform two similar structural bending tests. The results indicate that the flexural stiffness which is generally governing the load bearing capacity of floors, is fully restored by the rehabilitation work. The results also indicate that bending capacity, which can be governing for relatively short floor spans, is restored and possibly increased by the rehabilitation work. The shear capacity which is only critical for short floor spans in combination with very high loads is, however, reduced, as the experimental shear capacity is 18% lower than the characteristic shear capacity.
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| 15. |
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| 16. |
- Brulin, E., et al.
(författare)
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Healthcare in distress: A survey of mental health problems and the role of gender among nurses and physicians in Sweden
- 2023
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Ingår i: Journal of Affective Disorders. - : Elsevier. - 0165-0327 .- 1573-2517. ; 339, s. 104-110
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Tidskriftsartikel (refereegranskat)abstract
- Introduction:The present article aimed to investigate 1) if mental health problems (depression and burnout including the dimensions; emotional exhaustion, mental distance and cognitive and emotional impairment) differed between nurses and physicians in Sweden, 2) if any differences were explained by differences in sex compositions, and 3) if any sex differences were larger within either of the two professions. Method:Data were derived from a representative sample of nurses (n = 2903) and physicians (n = 2712) in 2022. Two scales were used to assess burnout (KEDS and BAT) and one to assess depression (SCL-6). The BAT scale has four sub-dimensions. Descriptive statistics and logistic regression were used to analyse each scale and dimension separately. Results:Results showed that 16-28 % of nurses and physicians reported moderate to severe symptoms of burnout. The prevalence differed between occupations across the scales and dimensions used. Nurses reported higher scores on KEDS while physicians reported higher scores on BAT including the four dimensions. Also, 7 % of nurses' and 6 % of physicians' scores were above the cut-off for major depression. The inclusion of sex in the models changed the odds ratios of differences between doctors and nurses in all mental health dimensions except mental distance and cognitive impairment. Limitations: This study was based on cross-sectional survey data which has some limitations. Conclusion:Our study suggests that the prevalence of mental health problems is prominent among nurses and physicians in Sweden. Sex plays an important role in the difference in the prevalence of mental health problems between the two professions.
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| 17. |
- Challis, Pontus, et al.
(författare)
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Validation of the diagnosis of necrotising enterocolitis in a Swedish population-based observational study
- 2019
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Ingår i: Acta Paediatrica. - : Wiley. - 0803-5253 .- 1651-2227. ; 108:5, s. 835-841
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Tidskriftsartikel (refereegranskat)abstract
- Aim: The definition of necrotising enterocolitis (NEC) is based on clinical and radiological signs that can be difficult to interpret. The aim of the present study was to validate the incidence of NEC in the Extremely Preterm Infants in Sweden Study (EXPRESS)Methods: The EXPRESS study consisted of all 707 infants born before 27 + 0 gestational weeks during the years 2004–2007 in Sweden. Of these infants, 38 were recorded as having NEC of Bell stage II or higher. Hospital records were obtained for these infants. Furthermore, to identify missed cases, all infants with a sudden reduction of enteral nutrition, in the EXPRESS study were identified (n = 71). Hospital records for these infants were obtained. Thus, 108 hospital records were obtained and scored independently by two neonatologists for NEC.Results: Of 38 NEC cases in the EXPRESS study, 26 were classified as NEC after validation. Four cases not recorded in the EXPRESS study were found. The incidence of NEC decreased from 6.3% to 4.3%.Conclusion: Validation of the incidence of NEC revealed over- and underestimation of NEC in the EXPRESS study despite carefully collected data. Similar problems may occur in other national data sets or quality registers.
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| 18. |
- De Marchi, Tommaso, et al.
(författare)
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Proteogenomics decodes the evolution of human ipsilateral breast cancer
- 2023
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Ingår i: Communications Biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 6:1
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Tidskriftsartikel (refereegranskat)abstract
- Ipsilateral breast tumor recurrence (IBTR) is a clinically important event, where an isolated in-breast recurrence is a potentially curable event but associated with an increased risk of distant metastasis and breast cancer death. It remains unclear if IBTRs are associated with molecular changes that can be explored as a resource for precision medicine strategies. Here, we employed proteogenomics to analyze a cohort of 27 primary breast cancers and their matched IBTRs to define proteogenomic determinants of molecular tumor evolution. Our analyses revealed a relationship between hormonal receptors status and proliferation levels resulting in the gain of somatic mutations and copy number. This in turn re-programmed the transcriptome and proteome towards a highly replicating and genomically unstable IBTRs, possibly enhanced by APOBEC3B. In order to investigate the origins of IBTRs, a second analysis that included primaries with no recurrence pinpointed proliferation and immune infiltration as predictive of IBTR. In conclusion, our study shows that breast tumors evolve into different IBTRs depending on hormonal status and proliferation and that immune cell infiltration and Ki-67 are significantly elevated in primary tumors that develop IBTR. These results can serve as a starting point to explore markers to predict IBTR formation and stratify patients for adjuvant therapy.
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| 19. |
- Eriksson, Lennart, et al.
(författare)
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Megavariate analysis of hierarchical QSAR data
- 2002
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Ingår i: Journal of Computer-Aided Molecular Design. ; 16:10, s. 711-26
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Tidskriftsartikel (refereegranskat)abstract
- Multivariate PCA- and PLS-models involving many variables are often difficult to interpret, because plots and lists of loadings, coefficients, VIPs, etc, rapidly become messy and hard to overview. There may then be a strong temptation to eliminate variables to obtain a smaller data set. Such a reduction of variables, however, often removes information and makes the modelling efforts less reliable. Model interpretation may be misleading and predictive power may deteriorate.A better alternative is usually to partition the variables into blocks of logically related variables and apply hierarchical data analysis. Such blocked data may be analyzed by PCA and PLS. This modelling forms the base-level of the hierarchical modelling set-up. On the base-level in-depth information is extracted for the different blocks. The score vectors formed on the base-level, here called `super variables', may be linked together in new matrices on the top-level. On the top-level superficial relationships between the X- and the Y-data are investigated.In this paper the basic principles of hierarchical modelling by means of PCA and PLS are reviewed. One objective of the paper is to disseminate this concept to a broader QSAR audience. The hierarchical methods are used to analyze a set of 10 haloalkanes for which K = 30 chemical descriptors and M = 255 biological responses have been gathered. Due to the complexity of the biological data, they are sub-divided in four blocks. All the modelling steps on the base-level and the top-level are reported and the final QSAR model is interpreted thoroughly.
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| 20. |
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| 21. |
- Gabrielsson, Jon, et al.
(författare)
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Multivariate methods in the development of a new tablet formulation : optimization and validation
- 2004
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Ingår i: Drug Development and Industrial Pharmacy. - New York : M. Dekker. - 0363-9045 .- 1520-5762. ; 30:10, s. 1037-1049
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Tidskriftsartikel (refereegranskat)abstract
- In a previous study of the development of a tablet formulation approximately 100 excipients were characterized in screening experiments using multivariate design. Acceptable values for important responses were obtained with some of the formulations. The relationships between the properties of the excipients and the responses were evaluated using PLS. In this study additional experiments were performed in order to validate models obtained from the screening study and to find a formulation of suitable composition with desired tablet properties. A formulation with the desired disintegration time was found with the additional experiments and the agreement between observed and predicted values was fair for the tablets that did disintegrate. A limitation of this study was that tablets from four experiments did not disintegrate within the set time limit. The lack of agreement between observed and predicted values of these four experiments was probably due to the nature of one of the factors in the design. Considering the reduced experimental design the results are still encouraging.
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| 22. |
- Gabrielsson, Jon, et al.
(författare)
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Multivariate Methods in the Development of a New Tablet Formulation
- 2003
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Ingår i: Drug Development and Industrial Pharmacy. - New York : Marcel Dekker. - 0363-9045 .- 1520-5762. ; 29:10, s. 1053-1075
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Tidskriftsartikel (refereegranskat)abstract
- The overall objective of this article is to use an efficient approach to find a suitable tablet formulation for direct compression. By using traditional approaches to statistical experimental design in tablet formulation, the number of experiments quickly grows when many descriptive variables or many excipients are included. To facilitate the screening process, a multivariate design, which allows a systematical evaluation of a large number of excipients with a limited number of experiments, was implemented. Formulations with acceptable values for disintegration time and crushing strength were obtained with some of the formulations in the present study. The multivariate experimental design strategy yielded PLS models that will be used to identify a region of interest for the optimization. The strategy is general and can be applied in many different areas of pharmaceutical research and development.
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| 23. |
- Gialamas, Spyros, et al.
(författare)
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Amino acid infusions in umbilical artery catheters enhance protein administration in infants born at extremely low gestational age
- 2022
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Ingår i: Acta Paediatrica. - : John Wiley & Sons. - 0803-5253 .- 1651-2227. ; 111:3, s. 536-545
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Tidskriftsartikel (refereegranskat)abstract
- AIM: It is challenging to provide extremely low gestational age neonates (ELGANs) with adequate protein supply. This study aimed to investigate whether amino acid (AA) infusion in the umbilical artery catheter (UAC) in ELGANs is safe and enhances protein supply and growth.METHOD: A before and after study including infants born <27 weeks, treated in Uppsala, Sweden, during 2004-2007, compared those receiving normal saline/10% dextrose in water with those receiving AA infusion in the UAC. Data were retrieved from the Extremely Preterm Infants in Sweden Study, hospital records and the Swedish Neonatal Quality Register. Group comparisons, univariate and multivariate analyses were conducted.RESULTS: AA group (n = 41, females 39%) received on average approximately 0.3 g/kg/day more protein during the first postnatal week, compared to control group (n = 30, females 40%) (unstandardised coefficient (B) 0.26, p .001) but no difference was noted during 8-28 postnatal days. The type of infusion was not associated with growth variables. The incidence of neonatal morbidities and UAC-related thrombosis did not differ between the groups.CONCLUSION: AA infusions in the UACs in ELGANs is safe and enhances protein supply during the first postnatal week. However, this practice is not associated with growth during the first 28 postnatal days.
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| 24. |
- Gummesson, Sara, et al.
(författare)
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The spatial organization of bone craft during the Middle and Late Mesolithic : Patterns of bone tool production at Ringsjöholm and Strandvägen in Sweden
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- This paper focuses on the spatial distribution of osseous tool production debitage from two Mesolithic sites in Sweden, Ringsjöholm and Strandvägen, with well-preserved faunal remains including high numbers of osseous artifacts. Local production of osseous tools on both sites has generated a variety of identifiable unfinished products and debitage deriving from complete chains of production, including unmodified bones, various kinds of debitage and finished products. Identified categories include: anatomical and technical blanks, removed epiphyses, bone flakes and preforms. Identification of species and element distributions show that antler and metapodial bone from red deer was the preferred raw material. Technological characteristics of the osseous craft and different stages of production have been identified. Spatial statistical analyses confirm that different stages of osseous tool production were organized within separate areas of the sites and that larger items were discarded in the water along the shorelines adjacent to the settlements. Interestingly, blanks and preforms seem to have been stored under water for future use. At Strandvägen demarcated clusters of bone flakes in association with dwellings represent craft areas, or "bone knapping floors" where production was more intense than in other areas.
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| 25. |
- Gummesson, Sara, et al.
(författare)
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The Spatial Organization of Bone Crafting During the Middle and Late Mesolithic at Ringsjöholm and Strandvägen in Sweden
- 2019
-
Ingår i: Journal of field archaeology. - : ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD. - 0093-4690 .- 2042-4582. ; 44:3, s. 165-179
-
Tidskriftsartikel (refereegranskat)abstract
- This paper focuses on the spatial distribution of bone tool production waste from two Mesolithic sites in Sweden, Ringsjoholm and Strandvagen, with well-preserved faunal remains including bone and antler artifacts. Local production on both sites has generated a variety of identifiable waste products deriving from complete chains of production, including unmodified bones, debitage and finished products. Identified categories include: blanks, removed epiphyses, bone flakes, and preforms. Identification of species shows that antler and bone from red deer were the preferred raw materials. Spatial statistical analyses confirm that different stages of bone tool production were organized within separate areas of the sites and that larger items were discarded in the water along the shorelines. Interestingly, blanks and preforms seem to have been stored under water for future use and demarcated clusters of bone flakes in association with dwellings represent "bone knapping floors" where production was more intense than in other areas.
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| 26. |
- Hagqvist, Emma, 1980-, et al.
(författare)
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The Swedish HealthPhys Study: Study Description and Prevalence of Clinical Burnout and Major Depression among Physicians
- 2022
-
Ingår i: Chronic Stress. - : SAGE Publications. - 2470-5470. ; 6
-
Tidskriftsartikel (refereegranskat)abstract
- Objectives: The study purpose was to describe the Swedish HealthPhys cohort. Using data from the HealthPhys study, we aimed to describe the prevalence of clinical burnout and major depression in a representative sample of Swedish physicians across gender, age, worksite, hierarchical position, and speciality in spring of 2021, during the third wave of the Covid-19 pandemic. Method: The HealthPhys questionnaire was sent to a representative sample of practising physicians (n = 6699) in Sweden in February to May of 2021 with a 41.3% response rate. The questionnaire included validated instruments measuring psychosocial work environment and health including measurements for major depression and clinical burnout. Results: Data from the HealthPhys study showed that among practising physicians in Sweden the prevalence of major depression was 4.8% and clinical burnout was 4.7%. However, the variations across sub-groups of physicians regarding major depression ranged from 0% to 10.1%. For clinical burnout estimates ranged from 1.3% to 14.5%. Emergency physicians had the highest levels of clinical burnout while they had 0% prevalence of major depression. Prevalence of exhaustion was high across all groups of physicians with physicians working in emergency departments, at the highest (28.6%) and anaesthesiologist at the lowest (5.6%). Junior physicians had high levels across all measurements. Conclusions: In conclusion, the first data collection from the HealthPhys study showed that the prevalence of major depression and clinical burnout varies across genders, age, hierarchical position, worksite, and specialty. Moreover, many practising physicians in Sweden experienced exhaustion and were at high risk of burnout.
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| 27. |
- Hallberg, Emil, et al.
(författare)
-
Termisk påverkan från läckande gasolslangar
- 2019
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Thermal influence from leaking liquefied petroleum gas: The radiant heat flux from 3 leakage scenarios of liquefied petroleum gas (LPG) was studied to determine safety distances when refilling LPG tanks from tank trucks. The three scenarios were a larger and a smaller leakage from a pipe and leakage from a textile reinforced rubber hose. Steady state tests with 5 minutes of burn time were performed as well as tests with 1 minute of burn time after which the emergency stop was activated. Measurements with water cooled heat flux meters and plate thermometers were used to determine heat flux levels. Measurements were designed to determine distances to heat fluxes of 12.5, 15 and 40 kW/m². Heat fluxes were measured both parallel and perpendicular to the flames at the same height as the leakage and 1 meter above the leakage.
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| 28. |
- Hansson, Fredrik, et al.
(författare)
-
Didaktisk bildning som alternativ till PCK
- 2016
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Vilka kunskaper är det som skapar själva lärarprofessionen? I högskoleförordningen (SFS 1993:100) benämns en del av det som ”kunskaper i didaktik och ämnesdidaktik inklusive metodik” och det spänner alltså från övergripande undervisningsperspektiv till den enskilda lärarens praktik. Vi är intresserade av hur ”det stora” (värdegrund, kunskaper om globala utmaningar, ”citizenship education”, didaktiska teorier etc., eller om man så vill didaktisk bildning) kommer till uttryck i ”det lilla”, alltså praxis. Vi använder begreppet didaktisk bildning som ett fylligare och mer mångbottnat alternativ till det anglosaxiska ”Pedagogical Content Knowledge” (PCK), som under senare år har gjort tydliga insteg i svensk ämnesdidaktisk forskning. PCK tar sin utgångspunkt i frågan vilka didaktiska kunskaper som den gode ämnesläraren behöver. Kansanen (2009) menar att PCK fokuserar på den didaktiska hur-frågan, medan den tyska didaktiktraditionen är inriktad på varför-frågan och dess följder för praxis. Med begreppet didaktisk bildning vill vi således anslå ett perspektiv som riktar blicken såväl inåt – mot det som sker i klassrummet – som utåt – mot exempelvis debatt, diskurser och traditioner som påverkar läraren. Den didaktiskt bildade läraren har en mångfacetterad förståelse för undervisningsämnet (inklusive goda kunskaper både i och om ämnet) och problematiserar dess selektiva traditioner. Hen har kunskap, bildning och handlingskompetens att självständigt fatta didaktiska beslut som gör att ”det stora” kommer till uttryck i ”det lilla”. Tillsammans representerar vi tre olika ämnesdidaktiska spår: språk- och litteraturdidaktik, SO-didaktik respektive NO-didaktik.
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| 29. |
- Just, Alar, et al.
(författare)
-
CLT compartment fire test
- 2018
-
Ingår i: WCTE 2018 - World Conference on Timber Engineering.
-
Konferensbidrag (refereegranskat)abstract
- New high-rise timber buildings are planned to be built in the near future all around the world. The fire protection concepts are not always considering natural fire scenarios. As timber is a combustible material, it can contribute to the fire within and outside of the fire compartment. For buildings with cross-laminated timber (CLT) elements the possible fall-off of lamellas should be considered because of the risk for second flashover, which can lead to a continuous fire. However, in case fire service interference or sprinkler activation is absent or inefficient, it may be necessary to design a building so that it leads to a decaying fire. Additionally, it is important to limit fire spread to neighbouring compartments. This paper discusses a compartment test of a two-story building made of CLT performed in Estonia to study delamination behaviour and consequences in compartments with realistic ventilation conditions. State-of-the art solutions to limit fire spread from the first floor into the second floor were applied. This involved robust design of connections, penetrations through the compartment boundary and the façade. The paper provides a description and analysis of the test.
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| 30. |
- Kadi, Fawzi, et al.
(författare)
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Effects of one bout of endurance exercise on the expression of myogenin in human quadriceps muscle
- 2004
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Ingår i: Histochemistry and Cell Biology. - : Springer Science and Business Media LLC. - 0948-6143 .- 1432-119X. ; 121:4, s. 329-334
-
Tidskriftsartikel (refereegranskat)abstract
- The objective of this study was to investigate the cellular localisation of MyoD and myogenin in human skeletal muscle fibres as well as the possible alterations in the expression of MyoD and myogenin in response to a single bout of endurance exercise at 40% and 75% of maximum oxygen uptake (VO(2) max). Twenty-five biopsies (5 per subject) from the vastus lateralis muscle were obtained before exercise, from the exercising leg at 40% and 75% of VO(2) max and from the resting leg following these exercise bouts. The tyramide signal amplification-direct and the Vectastain ABC methods using specific monoclonal antibodies were used to determine the exact location of myogenin and MyoD, to identify muscle satellite cells and to determine myosin heavy chain (MyHC) composition. At rest, myonuclei did not express MyoD or myogenin. Following a single bout of exercise at 40% and 75% of VO(2) max, an accumulation of myogenin in myonuclei and not in satellite cells was observed in biopsies from the exercised leg but not in biopsies before exercise and from the resting leg. The number of myogenin-positive myonuclei varied among individuals indicating differences in the response to a single exercise bout. In conclusion, this immunohistochemical study showed that a rapid rearrangement of myogenin expression occurs in exercised human skeletal muscles in response to a single bout of exercise.
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| 31. |
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| 32. |
- Mark-Herbert, Cecilia, et al.
(författare)
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Urban Planners’ Perspectives on Public Private Partnership for Wooden Multistorey Construction
- 2023
-
Ingår i: Journal of Forest Economics. - : Now Publishers. - 1104-6899 .- 1618-1530. ; 38, s. 7-35
-
Tidskriftsartikel (refereegranskat)abstract
- Increased awareness of sustainable development in the construction industry and current housing shortages have contributed to market opportunities for wooden multi-storey construction (WMC) in the Nordic countries. However, the market development has been slow despite access to forest products and a political ambition to transform to a low carbon society. The aim of this study is to explain enabling factors for municipalities in Sweden to create institutional conditions that stimulate local market development of WMC. A comparative case study of municipal efforts to establish WMC norms has been conducted pointing to the importance of relationships, in so-called public private partnerships (PPP). These partnerships serve as long-lasting relations in which development processes can manage challenges relating to, for example, lack of professional experience in WMC and dated material understandings of wood as a construction material. In the Sustainable Development Goals, PPP represent enabling conditions for sustainable system transformations.
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| 33. |
- Narbe, Ulrik, et al.
(författare)
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AIB1 is a new putative prognostic biomarker in the luminal A and B-like (HER2-negative) classification of invasive lobular carcinoma
- 2017
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Ingår i: ; , s. 1-07
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Konferensbidrag (refereegranskat)abstract
- Body: Background: Estrogen receptor (ER) positive HER2-negative breast cancer comprises 75–80% of all breast cancer. Thisfraction is even higher (>90%) in invasive lobular carcinoma (ILC). According to the St Gallen surrogate definitions of the intrinsicsubtypes, Ki67 and progesterone receptor (PgR) are used to classify these tumors as luminal A- and luminal B-like(HER2-negative). These guidelines are based on information derived from patient materials with mixed histological types, wherethe vast majority of the patients have invasive ductal carcinoma. The `luminal-like classification´ together with histological grade,tumor size and lymph node status is widely used in the clinic for prognostication. The aim of the present study was to investigateif the same markers are applicable for ILC, and furthermore, if additional biomarkers involved in the endocrine signaling system,e.g. Amplified in breast cancer 1 (AIB1) and the putative G protein-coupled estrogen receptor (GPER), might providecomplementary prognostic information.Patients: Two hundred and thirty-three (N = 233) well-characterized patients with primary ILC, diagnosed between 1980 and1991 were included. Forty-two percent of the patients received adjuvant endocrine treatment and 2 % received adjuvantchemotherapy. All biomarkers were analyzed immunohistochemically on tissue microarray, whereas histological grade wasevaluated on whole sections according to Elston and Ellis (NHG). The primary endpoint was breast cancer mortality (BCM).Results: In univariable analyses with 10-year follow-up, Ki67 (high vs. low), NHG (3 vs. 1+2) and AIB1 (high vs. low) weresignificantly associated to BCM (Hazard Ratio: 4.7, 95% CI: 2.1–10.4, p 95% CI: 1.4–7.2, p = 0.005 respectively), whereas PgR (respectively). Essentially the same effect was seen after multivariable adjustment for lymph node status (+ vs. -), tumor size (>20mm vs. according to St Gallen surrogate definitions did not show significant prognostic differences between the two groups (p = 0.12).Patients with AIB1) had a 10-year BCM of 4.2% (95% CI: 1.4–12%). This group constituted 34% of the patients included in the present study.Conclusions: In contrast to other previous studies, where breast cancers of mixed histological types were included, PgR was notsignificantly associated to prognosis in the ER-positive HER2-negative subgroup in the present study, consisting only of ILC. Theprognostic role of PgR and the clinical usefulness of the luminal A and B-like (HER2-negative) classification (using only Ki67 andPgR) in ILC is still to be further investigated. The prognostic importance of Ki67 and NHG in this subgroup was, however,confirmed also in ILC, and AIB1 might be a new putative prognostic factor. By combining Ki67, NHG, and AIB1, together withlymph node status and tumor size, a group of patients with an excellent prognosis could be identified.
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| 34. |
- Narbe, Ulrik, et al.
(författare)
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The estrogen receptor coactivator AIB1 is a new putative prognostic biomarker in ER-positive/HER2-negative invasive lobular carcinoma of the breast
- 2019
-
Ingår i: Breast Cancer Research and Treatment. - : Springer Science and Business Media LLC. - 0167-6806 .- 1573-7217. ; 175:2, s. 305-316
-
Tidskriftsartikel (refereegranskat)abstract
- Purpose: According to the 2017 St Gallen surrogate definitions of the intrinsic subtypes, Ki67, progesterone receptor (PR) and Nottingham histological grade (NHG) are used for prognostic classification of estrogen receptor (ER) positive/HER2-negative breast cancer into luminal A- or luminal B-like. The aim of the present study was to investigate if additional biomarkers, related to endocrine signaling pathways, e.g., amplified in breast cancer 1 (AIB1), androgen receptor (AR), and G protein-coupled estrogen receptor (GPER), can provide complementary prognostic information in a subset of ER-positive/HER-negative invasive lobular carcinoma (ILC). Methods: Biomarkers from 224 patients were analyzed immunohistochemically on tissue microarray. The primary endpoint was breast cancer mortality (BCM), analyzed with 10- and 25-year follow-up (FU). In addition, the prognostic value of gene expression data for these biomarkers was analyzed in three publicly available ILC datasets. Results: AIB1 (high vs. low) was associated to BCM in multivariable analysis (adjusted for age, tumor size, nodal status, NHG, Ki67, luminal-like classification, and adjuvant systemic therapy) with 10-year FU (HR 6.8, 95% CI 2.3–20, P = 0.001) and 25-year FU (HR 3.0, 95% CI 1.1–7.8, P = 0.03). The evidence of a prognostic effect of AIB1 could be confirmed by linking gene expression data to outcome in independent publicly available ILC datasets. AR and GPER were neither associated to BCM with 10-year nor with 25-year FU (P > 0.33). Furthermore, Ki67 and NHG were prognostic for BCM at both 10-year and 25-year FU, whereas PR was not. Conclusions: AIB1 is a new putative prognostic biomarker in ER-positive/HER2-negative ILC.
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| 35. |
- Nilsson, Daniel, 1982-
(författare)
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A ΔJ approach for nonlinear fatigue crack propagation : Experimental and numerical investigation of a ductile superalloy
- 2024
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This dissertation is a product of an academic-industrial collaboration between the Division of Solid Mechanics at Linköping University and Siemens Energy AB. The focus is on enhancing the design optimisation procedures for high-temperature components in industrial gas turbines (IGT). The research is centred around the behaviour of the nickelbased high-temperature superalloy Haynes 230 under service-like conditions with predominant thermal loads. The aim is to improve fatigue crack propagation life predictions for nonlinear conditions.The research findings validate the thermal ageing fatigue effects on Haynes 230 as seen in existing literature, especially on constitutive properties and crack initiation. Additionally, it was observed that thermal ageing has a minor effect on the crack growth rate up to 600 °C, which can be managed by updating the crack driving force with thermally aged properties.The project mainly focused on nonlinear crack propagation at isothermal and thermomechanical fatigue conditions. A new method for crack length description, using a modified compliance method, is introduced. This method simplifies and enhances the accuracy of crack length measurements and has become an established method for evaluating the single edge notch specimen used in the project under thermo-mechanical fatigue conditions.The nonlinear fatigue parameter ΔJ was incorporated into both Finite element method (FEM) computations and test evaluations, revealing linear trends with crack growth rates in loglog. The research highlights the crucial role of crack opening in establishing a correlation between ΔJ and crack growth rate. It was also concluded that the linear fatigue fracture parameter ΔK tends to underestimate the crack growth behaviour, resulting in non-conservative outcomes if the elasto-plastic stresses from the tests are considered.Lastly, a constitutive description of Haynes 230, based on the Ohno-Wang theory, under negligible viscoplastic effects, and an extension of the cycle jumping procedure that takes into account the significant hardening between the initial and midlife stages of the material, is presented. By this the notched geometry in 3D could be simulated with satisfying accuracy.
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| 36. |
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| 37. |
- Pettersson, Fredrik, 1974-
(författare)
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A multivariate approach to computational molecular biology
- 2005
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis describes the application of multivariate methods in analyses of genomic DNA sequences, gene expression and protein synthesis, which represent each of the steps in the central dogma of biology. The recent finalisation of large sequencing projects has given us a definable core of genetic data and large-scale methods for the dynamic quantification of gene expression and protein synthesis. However, in order to gain meaningful knowledge from such data, appropriate data analysis methods must be applied. The multivariate projection methods, principal component analysis (PCA) and partial least squares projection to latent structures (PLS), were used for clustering and multivariate calibration of data. By combining results from these and other statistical methods with interactive visualisation, valuable information was extracted and further interpreted. We analysed genomic sequences by combining multivariate statistics with cytological observations and full genome annotations. All oligomers of di- (16), tri- (64), tetra- (256), penta- (1024) and hexa-mers (4096) of DNA were separately counted and normalised and their distributions in the chromosomes of three Drosophila genomes were studied by using PCA. Using this strategy sequence signatures responsible for the differentiation of chromosomal elements were identified and related to previously defined biological features. We also developed a tool, which has been made publicly available, to interactively analyse single nucleotide polymorphism data and to visualise annotations and linkage disequilibrium. PLS was used to investigate the relationships between weather factors and gene expression in field-grown aspen leaves. By interpreting PLS models it was possible to predict if genes were mainly environmentally or developmentally regulated. Based on a PCA model calculated from seasonal gene expression profiles, different phases of the growing season were identified as different clusters. In addition, a publicly available dataset with gene expression values for 7070 genes was analysed by PLS to classify tumour types. All samples in a training set and an external test set were correctly classified. For the interpretation of these results a method was applied to obtain a cut-off value for deciding which genes could be of interest for further studies. Potential biomarkers for the efficacy of radiation treatment of brain tumours were identified by combining quantification of protein profiles by SELDI-MS-TOF with multivariate analysis using PCA and PLS. We were also able to differentiate brain tumours from normal brain tissue based on protein profiles, and observed that radiation treatment slows down the development of tumours at a molecular level. By applying a multivariate approach for the analysis of biological data information was extracted that would be impossible or very difficult to acquire with traditional methods. The next step in a systems biology approach will be to perform a combined analysis in order to elucidate how the different levels of information are linked together to form a regulatory network.
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| 38. |
- Sjöström, Carin, et al.
(författare)
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Treatment according to guidelines may bridge the gender gap in outcome for patients with stage T1 urinary bladder cancer
- 2018
-
Ingår i: Scandinavian Journal of Urology. - : Medical Journals Sweden AB. - 2168-1805 .- 2168-1813. ; 52:3, s. 186-193
-
Tidskriftsartikel (refereegranskat)abstract
- Objective: The aim of this investigation was to study differences between male and female patients with stage T1 urinary bladder cancer (UBC) regarding intravesical instillation therapy, second resection and survival. Materials and methods: This study included all patients with non-metastatic primary T1 UBC reported to the Swedish National Register of Urinary Bladder Cancer (SNRUBC) from 1997 to 2014, excluding those treated with primary cystectomy. Differences between groups were evaluated using chi-squared tests and logistic regression, and survival was investigated using Kaplan–Meier and log-rank tests and Cox proportional hazards analysis. Results: In all, 7681 patients with T1 UBC (77% male, 23% female) were included. Females were older than males at the time of diagnosis (median age at presentation 76 and 74 years, respectively; p < .001). A larger proportion of males than females underwent intravesical instillation therapy (39% vs 33%, p < .001). Relative survival was lower in women aged ≥75 years and women with G3 tumours compared to men. However, women aged ≥75 years who had T1G3 tumours and underwent second resection followed by intravesical instillation therapy showed a relative survival equal to that observed in men. Conclusions: This population-based study demonstrates that women of all ages with T1 UBC undergo intravesical instillation therapy less frequently than men, and that relative survival is poorer in women aged ≥75 years than in men of the same age when intravesical instillation therapy and second resection are not used. However, these disparities may disappear with treatment according to guidelines.
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| 39. |
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| 40. |
- Sjöström, Johan, 1978-, et al.
(författare)
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Exposure from mass timber compartment fires to facades
- 2021
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Different countries world-wide have different legislation concerning the performance of facades exposed to fire and often significantly different ways to assess this performance. Although it is recognized that standard façade fire testing aims to distinguish façade systems that limit fire spread to an acceptable level from systems that do not, it has historically been considered important that the fire exposure of such tests is representative for real fires.In this study five real scale compartment fire tests, constructed of Cross Laminated Timber and Glued laminated timber were performed with instrumentation on a façade extension above the ventilation openings, providing a means to compare façade performance tests against the exposure generated by realistic compartment fires. The fuel load and openings of four of these tests were determined from a statistical analysis to represent severe fire exposure within a realistic range. Of these tests the surface areas of exposed Cross Laminated Timber and Glued Laminated Timber were varied, allowing an assessment of the influence having internal areas of exposed timber surfaces on the façade fire exposure.For these tests, an increase of roughly 40 m2 exposed surface area (from ~54 to ~94 m2 or from 113 % to 196 % of the floor area) resulted in a temperature increase of roughly 100 to 130 °C at the façade at all heights up to 3.5 m above the opening. Additionally, an increased fire plume height of 0 to 1 m was observed. The most significant effect of increased exposed areas was a prolonged duration of the flashover phase.The British BS 8414 standard façade fire tests and the recently proposed European façade fire test have been identified to be the most representative for the tested residential fire scenarios in terms of façade fire exposure. Temperature measurements of the North American methods (NFPA 285 and CAN/ULC-S134) are towards the end of the tests also close to the those of the compartment tests. The Swedish SP Fire 105 test imposes the lowest exposure for a relatively short duration to the façade. It should, however, be noted that a lower exposure in the standard test method does not with necessity mean lower threshold for regulatory compliance as the test criteria also differ between different countries.One of the tests were characteristic of open plan office buildings and it was shown that the fire exposure is both shorter and lower compared to typical residential compartment tests. All standard tests that were used for comparison here exhibited both longer and higher exposure than the office building compartment test.
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| 41. |
- Sjöström, Johan, et al.
(författare)
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Large scale exposure of fires to facade - Initial testing of proposed European method
- 2021
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- This report describes a series of tests of the new proposed method for assessing the performance of façades when exposed to flashover fires. The tests consider the large fire exposure and consists of the 8.5 meter high incombustible walls placed in a 90° angle towards each other. The report assesses reproducibility and the effect of moisture content, stick size, wind and depth of the combustion chamber.The data from the report will be publicly available at the project website for further use and scrutiny. https://www.ri.se/en/what-we-do/projects/finalisation-of-the-european-approach-to-assess-the-fire-performance-of-facades
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| 42. |
- Sjöström, Martin, et al.
(författare)
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Identification and validation of single-sample breast cancer radiosensitivity gene expression predictors
- 2018
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Ingår i: Breast Cancer Research. - : Springer Science and Business Media LLC. - 1465-5411 .- 1465-542X. ; 20:1
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Adjuvant radiotherapy is the standard of care after breast-conserving surgery for primary breast cancer, despite a majority of patients being over- or under-treated. In contrast to adjuvant endocrine therapy and chemotherapy, no diagnostic tests are in clinical use that can stratify patients for adjuvant radiotherapy. This study presents the development and validation of a targeted gene expression assay to predict the risk of ipsilateral breast tumor recurrence and response to adjuvant radiotherapy after breast-conserving surgery in primary breast cancer. Methods: Fresh-frozen primary tumors from 336 patients radically (clear margins) operated on with breast-conserving surgery with or without radiotherapy were collected. Patients were split into a discovery cohort (N = 172) and a validation cohort (N = 164). Genes predicting ipsilateral breast tumor recurrence in an Illumina HT12 v4 whole transcriptome analysis were combined with genes identified in the literature (248 genes in total) to develop a targeted radiosensitivity assay on the Nanostring nCounter platform. Single-sample predictors for ipsilateral breast tumor recurrence based on a k-top scoring pairs algorithm were trained, stratified for estrogen receptor (ER) status and radiotherapy. Two previously published profiles, the radiosensitivity signature of Speers et al., and the 10-gene signature of Eschrich et al., were also included in the targeted panel. Results: Derived single-sample predictors were prognostic for ipsilateral breast tumor recurrence in radiotherapy-treated ER+ patients (AUC 0.67, p = 0.01), ER+ patients without radiotherapy (AUC = 0.89, p = 0.02), and radiotherapy-treated ER- patients (AUC = 0.78, p < 0.001). Among ER+ patients, radiotherapy had an excellent effect on tumors classified as radiosensitive (p < 0.001), while radiotherapy had no effect on tumors classified as radioresistant (p = 0.36) and there was a high risk of ipsilateral breast tumor recurrence (55% at 10 years). Our single-sample predictors developed in ER+ tumors and the radiosensitivity signature correlated with proliferation, while single-sample predictors developed in ER- tumors correlated with immune response. The 10-gene signature negatively correlated with both proliferation and immune response. Conclusions: Our targeted single-sample predictors were prognostic for ipsilateral breast tumor recurrence and have the potential to stratify patients for adjuvant radiotherapy. The correlation of models with biology may explain the different performance in subgroups of breast cancer.
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| 43. |
- Sjöström, Martin, et al.
(författare)
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Lack of G protein-coupled estrogen receptor (GPER) in the plasma membrane is associated with excellent long-term prognosis in breast cancer
- 2014
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Ingår i: Breast Cancer Research and Treatment. - : Springer Verlag (Germany). - 0167-6806 .- 1573-7217. ; 145:1, s. 61-71
-
Tidskriftsartikel (refereegranskat)abstract
- G protein-coupled estrogen receptor (GPER), or GPR30, is a membrane receptor reported to mediate non-genomic estrogen responses. Tamoxifen is a partial agonist at GPER in vitro. Here, we investigated if GPER expression is prognostic in primary breast cancer, if the receptor is treatment-predictive for adjuvant tamoxifen, and if receptor subcellular localization has any impact on the prognostic value. Total and plasma membrane (PM) GPER expression was analyzed by immunohistochemistry in breast tumors from 742 postmenopausal lymph node-negative patients subsequently randomized for tamoxifen treatment for 2-5 years versus no systemic treatment, regardless of estrogen receptor (ER) status, and with a median follow-up of 17 years for patients free of event. PM GPER expression was a strong independent prognostic factor for poor prognosis in breast cancer without treatment-predictive information for tamoxifen. In the tamoxifen-treated ER-positive and progesterone receptor (PgR)-positive patient subgroup, the absence of PM GPER (53 % of all ER-positive tumors) predicted 91 % 20-year distant disease-free survival, compared to 73 % in the presence of GPER (p = 0.001). Total GPER expression showed positive correlations with ER and PgR and negative correlation with histological grade, but the correlations were biphasic. On the other hand, PM GPER expression showed strong negative correlations with ER and PgR, and strong positive correlation with HER2 overexpression and high histological grade. GPER overexpression and PM localization are critical events in breast cancer progression, and lack of GPER in the PM is associated with excellent long-term prognosis in ER-positive and PgR-positive tamoxifen-treated primary breast cancer.
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| 44. |
- Späth, Cornelia, et al.
(författare)
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Associations between sodium supply, sodium imbalances and severe intraventricular haemorrhage in extremely preterm infants: A nested case-control study
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Background: Severe intraventricular haemorrhage (IVH) is a serious neonatal morbidity among extremely preterm infants that has been associated with adverse neurodevelopmental consequences. We aimed to explore the associations between sodium supply, sodium imbalances and severe IVH.Methods: We used data from the EXtremely PREterm Infants in Sweden Study (EXPRESS) including all extremely preterm infants (< 27 weeks) born during 2004 and 2007 in Sweden (n = 707) and conducted a nested case-control study. For every infant with severe IVH (grades 3 to 4, n = 70) one control infant with a normal cranial ultrasound, a birthday closest to the case infant, and matched for hospital, sex, gestational age, and birth weight was selected.Results: Sodium supply was higher in infants with severe IVH compared with controls [Daily sodium supply until postnatal day 2: Mean ± SD (mmol/kg/d): 5.49 ± 2.53 vs. 3.95 ± 1.91, P = 0.009]. This association did not remain significant when we excluded the amount of sodium delivered from transfused blood products from total sodium supply. High concentrations of or large fluctuations in plasma sodium were not related to severe IVH.Conclusion: Although our results suggest a relationship between sodium supply and severe IVH via blood product transfusions, it is unclear whether this represents an effect of solute or volume load.
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| 45. |
- Späth, Cornelia, et al.
(författare)
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Sodium supply from administered blood products was associated with severe intraventricular haemorrhage in extremely preterm infants
- 2022
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Ingår i: Acta Paediatrica. - : John Wiley & Sons. - 0803-5253 .- 1651-2227. ; 111:9, s. 1701-1708
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Tidskriftsartikel (refereegranskat)abstract
- Aim: The aim of this study was to investigate the associations between sodium supply, fluid volume, sodium imbalances and severe intraventricular haemorrhage (IVH) in extremely preterm (EPT) infants.Methods: We used data from the EXtremely PREterm infants in Sweden Study (EXPRESS) cohort consisting of all infants born at 22 to 26 gestational weeks from 2004 to 2007 and conducted a nested case–control study. For every infant with severe IVH (grade 3 or peri-ventricular haemorrhagic infarction), one IVH-free control infant with the birthday closest to the case infant and matched for hospital, sex, gestational age and birth weight was selected (n = 70 case–control pairs).Results: Total sodium supply and fluid volume were higher in infants with severe IVH compared with controls [daily total sodium supply until postnatal Day 2: mean ± SD (mmol/kg/day): 5.49 ± 2.53 vs. 3.95 ± 1.91, p = 0.009]. These differences were accounted for by sodium and fluid from transfused blood products. High plasma sodium concentrations or large sodium fluctuations were not associated with severe IVH.Conclusion: Our results suggest a relationship between sodium-rich transfusions of blood products and severe IVH in EPT infants. It is unclear whether this is an effect of sodium load, volume load or some other transfusion-related factor.
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| 46. |
- Späth, Cornelia, et al.
(författare)
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Sodium supply influences plasma sodium concentration and the risks of hyper- and hyponatremia in extremely preterm infants
- 2017
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Ingår i: Pediatric Research. - : Nature Publishing Group. - 0031-3998 .- 1530-0447. ; 81, s. 455-460
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Tidskriftsartikel (refereegranskat)abstract
- Background: Hyper- and hyponatremia occur frequently in extremely preterm infants. Our purpose was to investigate plasma sodium (P-Na) concentrations, the incidence of hyper and hyponatremia, and the impact of possible predisposing factors in extremely preterm infants.Methods: In this observational study, we analyzed data from the EXtremely PREterm (< 27 wk.) infants in Sweden Study (EXPRESS, n = 707). Detailed nutritional, laboratory, and weight data were collected retrospectively from patient records.Results: Mean ± SD P-Na increased from 135.5 ± 3.0 at birth to 144.3 ± 6.1 mmol/l at a postnatal age of 3 d and decreased thereafter. Fifty percent of infants had hypernatremia (P-Na >145 mmol/l) during the first week of life while 79% displayed hyponatremia (P-Na < 135 mmol/l) during week 2. Initially, the main sodium sources were blood products and saline injections/infusions, gradually shifting to parenteral and enteral nutrition towards the end of the first week. The major determinant of P-Na and the risks of hyper- and hyponatremia was sodium supply. Fluid volume provision was associated with postnatal weight change but not with P-Na.Conclusion: The supply of sodium, rather than fluid volume, is the major factor determining P-Na concentrations and the risks of hyper- and hyponatremia.
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| 47. |
- Stoltz Sjöström, Elisabeth, et al.
(författare)
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Intakes of micronutrients are associated with early growth in extremely preterm infants
- 2016
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Ingår i: Journal of Pediatric Gastroenterology and Nutrition - JPGN. - 0277-2116 .- 1536-4801. ; 62:6, s. 885-892
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: The aim of the study was to describe micronutrient intakes and explore possible correlations to growth during the first 70 days of life in extremely preterm infants.Methods: Retrospective population-based study including extremely preterm infants (<27 weeks) born in Sweden during 2004-2007. Detailed nutritional and growth data were derived from hospital records.Results: Included infants (n = 531) had a mean gestational age of 25 weeks and 2 days and a mean birth weight of 765 g. Estimated and adjusted intakes of calcium, phosphorus magnesium, zinc, copper, selenium, vitamin D, and folate were lower than estimated requirements, whereas intakes of iron, vitamin K, and several water-soluble vitamins were higher than estimated requirements. High iron intakes were explained by blood transfusions. During the first 70 days of life, taking macronutrient intakes and severity of illness into account, folate intakes were positively associated with weight (P = 0.001) and length gain (P = 0.003) and iron intake was negatively associated with length gain (P = 0.006).Conclusions: Intakes of several micronutrients were inconsistent with recommendations. Even when considering macronutrient intakes and severity of illness, several micronutrients were independent predictors of early growth. Low intake of folate was associated with poor weight and length gain. Furthermore, high iron supply was associated with poor growth in length and head circumference. Optimized early micronutrient supply may improve early growth in extremely preterm infants.
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| 48. |
- Stoltz Sjöström, Elisabeth, 1967-, et al.
(författare)
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Intakes of micronutrients is associated with early growth in extremely preterm infants : a population-based study
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Objectives: To describe micronutrient intakes and explore possible correlations to growth during the first 70 days of life in extremely preterm infants.Methods: Retrospective population-based study including extremely preterm infants (<27 weeks) born in Sweden during 2004-2007. Detailed nutritional and growth data were derived from hospital records.Results: Included infants (n=531), had a mean gestational age of 25 weeks+2 days and a mean birth weight of 765 g. Intakes of calcium, phosphorus magnesium, zinc, copper, iodine, vitamin D and folate were lower than estimated requirements while intakes of iron, vitamin K and several water-soluble vitamins were higher than estimated requirements. High iron intakes were explained by blood transfusions. During the first 70 days of life, taking macronutrient intakes and severity of illness into account, folate intakes were positively correlated with weight (p=0.001) and length gain (p=0.003) and iron intake was negatively associated with length gain (p=0.006).Conclusions: Intakes of many micronutrients were insufficient. Even when considering macronutrient intakes and severity of illness, several micronutrients were independent predictors of early growth. Low intakes of folate were associated with poor weight and length growth. Further, high iron intakes were associated with poor length and head circumference growth. Optimized early micronutrient intakes may improve early growth in extremely preterm infants.
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| 49. |
- Stoltz Sjöström, Elisabeth, et al.
(författare)
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Intakes Of Micronutrients Is Associated With Early Growth In Extremely Preterm Infants – A Population-based Study
- 2014
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Ingår i: Archives of Disease in Childhood. - : BMJ Publishing Group Ltd. - 0003-9888 .- 1468-2044.
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Konferensbidrag (refereegranskat)abstract
- Background: Extremely preterm infants have high nutrient requirements due to limited stores of nutrients and rapid postnatal growth. However, many infants experience suboptimal growth. It is still unclear to what extent micronutrient intakes affect growth during early postnatal life in these infants.Aim: To describe micronutrient intakes and explore possible associations with growth during the first 70 days of life inextremely preterm infants.Methods: Retrospective population-based study including extremely preterm infants (<27 weeks) born in Sweden during 2004–2007. Detailed nutritional and growth data were derived from hospital records.Results: Included infants (n = 531), had a mean gestational ageof 25 weeks+2 days and a mean birth weight of 765 g. Intakes of calcium, phosphorus magnesium, zinc, copper, iodine, vitaminD and folate were lower than estimated requirements while intakes of iron, vitamin K and several water-soluble vitamins were higher than estimated requirements. High iron intakes were explained by blood transfusions. Taking macronutrienti ntakes and severity of illness into account, folate intakes were positively correlated with weight (p = 0.001) and length gain (p= 0.003) and iron intake was negatively associated with length gain (p = 0.006) during the first 70 days of life.Conclusions: Intakes of many micronutrients were insufficient. Even when considering macronutrient intakes and severity of illness, several micronutrients were independent predictors of early growth. Low intakes of folate were associated with poor weight and length gain and high iron intakes were associated with poor length and head circumference growth. Optimised early micronutrient intakes may improve early growth in extremely preterm infants.
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| 50. |
- Stoltz Sjöström, Elisabeth, et al.
(författare)
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Micronutrient Intakes Affect Early Growth in Extremely Preterm Infants : Preliminary Results from a Swedish Cohort
- 2011
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Ingår i: Pediatric Research. - : Nature Publishing Group. - 1530-0447 .- 0031-3998.
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Konferensbidrag (refereegranskat)abstract
- Background: Extremely preterm infants generally experience postnatal growth failure. It is still unclear if this is related to micronutrient intakes.Aim: To investigate the effect of micronutrient intakes (calcium, zinc, iron, phosphorus, sodium, potassium, chloride, magnesium, vitamin A, vitamin D, vitamin E, folate and vitamin B12) on growth during the first 28 days of life in extremely preterm infants.Method: From the EXPRESS cohort (all infants born < 27 gestational weeks between 2004-2007 in Sweden), those who survived the first 28 days were included (n=524). Daily parenteral and enteral intakes and anthropometric measurements were retrieved from hospital records.Results: Preliminary analyses of data from 333 infants (mean±SD gestational age 25.2±1.0 weeks, birth weight 753±168g) showed that macronutrient intakes were lower than recommended (energy 98±13kcal/kg/day, protein 2.9±0.4g/kg/day). Infants showed postnatal growth failure: mean standard deviation scores decreased by 2.2 for weight, 2.3 for length and 1.4 for head circumference. Intakes of micronutrients were generally low, e.g. adjusted enteral intakes of calcium were 66.6±21.4 mg/kg/day. The exception was iron, with a high parenteral intake of 2.7±1.6 mg/kg/day, mainly from blood transfusions. Adjusting for protein intake and other confounders, calcium intakes were positively correlated with head growth (r=+0.19, p=0.006) and iron intakes were negatively correlated with length gain (r=-0.18, p=0.009).Conclusions: Low calcium intakes and high iron intakes were associated with poor growth with regard to head circumference and length, respectively. If these results are confirmed, optimized micronutrient intakes may improve early growth in extremely preterm infants.
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