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- Al-Jarah, S. Y., et al.
(författare)
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Capillary electrophoretic and mass spectrometric analysis of a polydisperse fluorosurfactant
- 2005
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Ingår i: Journal of Separation Science. - : Wiley. - 1615-9306 .- 1615-9314. ; 28:3, s. 239-244
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Tidskriftsartikel (refereegranskat)abstract
- A fluorosurfactant has been studied using capillary electrophoresis and mass spectrometry. The fluorosurfactant, FC134, can be used as a buffer additive in capillary electrophoresis in order to decrease wall adsorption of proteins and in micellar electrokinetic chromatography. However, it has been discovered that this fluorosurfactant is polydisperse, thus containing substances with different lengths and structures. In this work, the fluorosurfactant sample components were separated by capillary electrophoresis. An uncoated as well as a poly(vinyl alcohol)-coated capillary were used with running electrolytes containing methanol and acetic acid. Following the capillary electrophoretic separation, fractions were collected for further analysis by MALDI-MS. Non-fractionated samples were also analyzed both by MALDI-MS and by ESI-MS.
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- Campieri, M, et al.
(författare)
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Oral budesonide is as effective as oral prednisolone in active Crohn's disease. The Global Budesonide Study Group
- 1997
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Ingår i: Gut. - : BMJ. - 0017-5749 .- 1468-3288. ; 41:2, s. 209-214
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Tidskriftsartikel (refereegranskat)abstract
- Background—The use of corticosteroids in active Crohn’s disease often becomes limited by side effects. Budesonide is a potent corticosteroid with low systemic bioavailability due to an extensive first pass liver metabolism.Aims—To compare the efficacy and safety of two dosage regimens of budesonide and prednisolone in patients with active Crohn’s disease affecting the ileum and/or the ascending colon.Patients and methods—One hundred and seventy eight patients were randomised to receive budesonide controlled ileal release (CIR) capsules 9 mg once daily or 4.5 mg twice daily, or prednisolone tablets 40 mg once daily. The treatment period was 12 weeks. The primary efficacy variable was clinical remission, defined as a Crohn’s Disease Activity Index (CDAI) of 150 or less.Results—After eight weeks of treatment, remission occurred in 60% of patients receiving budesonide once daily or prednisolone and in 42% of those receiving budesonide twice daily (p=0.062). The presence of glucocorticoid associated side effects was similar in all groups; however, moon face was more common in the prednisolone group (p=0.0005). The highest frequency of impaired adrenal function, as measured by a short ACTH test, was found in the prednisolone group (p=0.0023).Conclusions—Budesonide CIR, administered at 9 mg once daily or 4.5 mg twice daily, is comparable to prednisolone in inducing remission in active Crohn’s disease. The single dose administration is as promptly effective as prednisolone and represents a simpler and safer therapeutic approach, with a considerable reduction in side effects.
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- Sjodahl, P., et al.
(författare)
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Resistivity monitoring for leakage and internal erosion detection at Hallby embankment dam
- 2008
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Ingår i: Journal of Applied Geophysics. - : Elsevier BV. - 0926-9851. ; 65:3-4, s. 155-164
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Tidskriftsartikel (refereegranskat)abstract
- Internal erosion is one of the major reasons for embankment dam failures. Despite this, the knowledge of the temporal development of internal erosion in full scale structures is limited. Detection of internal erosion is complicated using conventional methods, and new or improved methods are appreciated. Hallby was the first Swedish embankment to get a permanently installed monitoring system intended for resistivity measurements. Daily measurements started to take place already in late 1996, which make these long term monitoring data unique. This paper includes examples of long term time series from Hallby along with some evaluation and interpretation techniques used when analysing such monitoring data. Time-lapse inversion was used to focus the variation over time and suppress artefacts due to the resistivity structure. Seasonal resistivity variations inside the dam are obvious. Increasing long term resistivity has been noticed in a particular zone in the left embankment. This zone also exhibits larger seasonal variations relative to other parts of the dam, and the variations are increasing. The observations may relate to an ongoing internal erosion process in the dam. The long term change may be indicative of a change in material properties, and the large and increasing variations may reflect higher and increasing seepage levels. In the years 2004 to 2006 the dam was upgraded and the resistivity system reinstalled. The results indicate that resistivity monitoring may have a chance of detecting development of internal erosion at an early stage. (C) 2008 Published by Elsevier B.V.
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- Sjodahl, P., et al.
(författare)
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Using the resistivity method for leakage detection in a blind test at the Rossvatn embankment dam test facility in Norway
- 2010
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Ingår i: Bulletin of Engineering Geology and the Environment. - : Springer Science and Business Media LLC. - 1435-9537 .- 1435-9529. ; 69:4, s. 643-658
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Tidskriftsartikel (refereegranskat)abstract
- Internal erosion is a cause of embankment dam failure, thus it is important to develop methods for seepage monitoring and internal erosion detection. In order to evaluate the potential of resistivity monitoring to give an early warning of such leakage/erosion, a test was undertaken on a rockfill embankment dam with a central glacial till core at the Rossvatn test facility in Norway. Three defects, consisting of permeable material, were built into the dam at various depths and locations unknown to the personnel carrying out the measurements and data interpretation. A numerical modelling pre-study was carried out, showing that all the actually constructed defects were too small to be detected by single time investigation. In the final test, repeated measurements were undertaken with different reservoir levels, i.e. a limited monitoring approach. This increased the detection capability, confirming the value of the geophysical approach and that monitoring is superior to single time investigations.
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