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Sökning: WFRF:(Skare L)

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  • Berglund, Johan, et al. (författare)
  • Prospective motion correction for diffusion weighted EPI of the brain using an optical markerless tracker.
  • 2021
  • Ingår i: Magnetic Resonance in Medicine. - : Wiley. - 0740-3194 .- 1522-2594. ; 85:3, s. 1427-1440
  • Tidskriftsartikel (refereegranskat)abstract
    • PURPOSE: To enable motion-robust diffusion weighted imaging of the brain using well-established imaging techniques.METHODS: An optical markerless tracking system was used to estimate and correct for rigid body motion of the head in real time during scanning. The imaging coordinate system was updated before each excitation pulse in a single-shot EPI sequence accelerated by GRAPPA with motion-robust calibration. Full Fourier imaging was used to reduce effects of motion during diffusion encoding. Subjects were imaged while performing prescribed motion patterns, each repeated with prospective motion correction on and off.RESULTS: Prospective motion correction with dynamic ghost correction enabled high quality DWI in the presence of fast and continuous motion within a 10° range. Images acquired without motion were not degraded by the prospective correction. Calculated diffusion tensors tolerated the motion well, but ADC values were slightly increased.CONCLUSIONS: Prospective correction by markerless optical tracking minimizes patient interaction and appears to be well suited for EPI-based DWI of patient groups unable to remain still including those who are not compliant with markers.
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  • Bexelius, C, et al. (författare)
  • Drivers of cost and health-related quality of life in patients with systemic lupus erythematosus (SLE): a Swedish nationwide study based on patient reports
  • 2013
  • Ingår i: Lupus. - : SAGE Publications. - 1477-0962 .- 0961-2033. ; 22:8, s. 793-801
  • Tidskriftsartikel (refereegranskat)abstract
    • The objective of this paper is to investigate drivers of cost and health-related quality of life (HRQoL) related to disease activity and fatigue among patients with systemic lupus erythematous (SLE). A questionnaire was sent to members of a patient organization with a self-reported diagnosis of SLE, requesting information on demographics and disease characteristics, medications, resource utilization, informal care, loss of productivity, fatigue and HRQoL in relation to SLE. Mean annual costs per patient were estimated from a societal perspective. HRQoL was measured through EQ-5D and fatigue was measured through a 10 cm VAS scale. Patient-reported disease activity was measured through the Systemic Lupus Activity Questionnaire (SLAQ) and corticosteroid dose. Drivers of costs and HRQoL were analyzed through regression analysis. A total of 339 patients out of 737 returned the questionnaire. Mean age was 55; 94% were female. The mean HRQoL measured through the five-item EQ-5D instrument was 0.64 and total costs were estimated at €22,594 (direct costs €7818; indirect costs €14,776). Disease activity, fatigue and corticosteroid doses had a statistically significant impact on costs and HRQoL. This study demonstrates that Swedish patients with SLE have low HRQoL and incur high societal costs and that are both associated with and most likely driven by disease activity, fatigue and corticosteroid use.
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  • Pilthammar, Johan, et al. (författare)
  • New press deflection measuring methods for the creation of substitutive models for efficient die cambering
  • 2021
  • Ingår i: INTERNATIONAL DEEP-DRAWING RESEARCH GROUP CONFERENCE (IDDRG 2021). - : IOP PUBLISHING LTD.
  • Konferensbidrag (refereegranskat)abstract
    • Cost and time for die tryout are significant within the car industry, and elastic deflections of dies and presses are most commonly not considered during the virtual die design and forming simulation phase. Because of this, active surfaces of stamping dies are only cambered based on previous experiences of tool types and presses. However, almost all stamping dies and presses are unique, and available experiences are not valid for new materials. Partners within the Eureka SMART Advanced Manufacturing research project CAMBER have developed advanced deflection measuring devices to quantify the elastic deformations of presses. Using these measurements, cambering methodologies can be utilized in sheet metal forming simulations. Important breakthroughs in recent years enabling the cambering methodology consists of efficient simulation strategies for full scale simulations with elastic dies and optimization techniques for creating substitutive press structures based on measurements. Furthermore, modem press deflection measurement methods are beneficial in applications such as Industry 4.0, predictive maintenance, product quality control, etc. through a more advanced understanding and live monitoring of the press system.
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