| 1. |
- Claassen, Y. H.M., et al.
(författare)
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North European comparison of treatment strategy and survival in older patients with resectable gastric cancer : A EURECCA upper gastrointestinal group analysis
- 2018
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Ingår i: European Journal of Surgical Oncology. - : Elsevier BV. - 0748-7983. ; 44:12, s. 1982-1989
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Tidskriftsartikel (refereegranskat)abstract
- Background: As older gastric cancer patients are often excluded from randomized clinical trials, the most appropriate treatment strategy for these patients remains unclear. The current study aimed to gain more insight in treatment strategies and relative survival of older patients with resectable gastric cancer across Europe. Methods: Population-based cohorts from Belgium, Denmark, The Netherlands, Norway, and Sweden were combined. Patients ≥70 years with resectable gastric cancer (cT1-4a, cN0-2, cM0), diagnosed between 2004 and 2014 were included. Resection rates, administration of chemotherapy (irrespective of surgery), and relative survival within a country according to stage were determined. Results: Overall, 6698 patients were included. The percentage of operated patients was highest in Belgium and lowest in Sweden for both stage II (74% versus 56%) and stage III disease (57% versus 25%). For stage III, chemotherapy administration was highest in Belgium (44%) and lowest in Sweden (2%). Three year relative survival for stage I, II, and III disease in Belgium was 67.8% (95% CI:62.8–72.6), 41.2% (95% CI:37.3–45.2), 17.8% (95% CI:12.5–24.0), compared with 56.7% (95% CI:51.5–61.7), 31.3% (95% CI:27.6–35.2), 8.2% (95% CI:4.4–13.4) in Sweden. There were no significant differences in treatment strategies of patients with stage I disease. Conclusion: Substantial treatment differences are observed across North European countries for patients with stages II and III resectable gastric cancer aged 70 years or older. In the present comparison, treatment strategies with a higher proportion of patients undergoing surgery seemed to be associated with higher survival rates for patients with stages II or III disease.
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| 2. |
- Miltiadous, O., et al.
(författare)
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Early intestinal microbial features are associated with CD4 T-cell recovery after allogeneic hematopoietic transplant
- 2022
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Ingår i: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 139:18, s. 2758-2769
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Tidskriftsartikel (refereegranskat)abstract
- Low intestinal microbial diversity is associated with poor outcomes after allogeneic hematopoietic cell transplantation (HCT). Using 16S rRNA sequencing of 2067 stool samples and flow cytometry data from 2370 peripheral blood samples drawn from 894 patients who underwent allogeneic HCT, we have linked features of the early post-HCT microbiome with subsequent immune cell recovery. We examined lymphocyte recovery and microbiota features in recipients of both unmodified and CD34-selected allografts. We observed that fecal microbial diversity was an independent predictor of CD4 T-cell count 3 months after HCT in recipients of a CD34-selected allograft, who are dependent on de novo lymphopoiesis for their immune recovery. In multivariate models using clinical factors and microbiota features, we consistently observed that increased fecal relative abundance of genus Staphylococcus during the early posttransplant period was associated with worse CD4 T-cell recovery. Our observations suggest that the intestinal bacteria, or the factors they produce, can affect early lymphopoiesis and the homeostasis of allograft-derived T cells after transplantation.
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| 3. |
- Claassen, Y. H. M., et al.
(författare)
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International comparison of treatment strategy and survival in metastatic gastric cancer
- 2019
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Ingår i: BJS Open. - : JOHN WILEY & SONS LTD. - 2474-9842. ; 3:1, s. 56-61
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundIn the randomized Asian REGATTA trial, no survival benefit was shown for additional gastrectomy over chemotherapy alone in patients with advanced gastric cancer with a single incurable factor, thereby discouraging surgery for these patients. The purpose of this study was to evaluate treatment strategies for patients with metastatic gastric cancer in daily practice in five European countries, along with relative survival in each country. MethodsNationwide population-based data from Belgium, Denmark, the Netherlands, Norway and Sweden were combined. Patients with primary metastatic gastric cancer diagnosed between 2006 and 2014 were included. The proportion of gastric resections performed and the administration of chemotherapy (irrespective of surgery) within each country were determined. Relative survival according to country was calculated. ResultsOverall, 15 057 patients with gastric cancer were included. The proportion of gastric resections varied from 81 per cent in the Netherlands and Denmark to 183 per cent in Belgium. Administration of chemotherapy was 392 per cent in the Netherlands, compared with 632 per cent in Belgium. The 6-month relative survival rate was between 390 (95 per cent c.i. 378 to 402) per cent in the Netherlands and 541 (521 to 569) per cent in Belgium. ConclusionThere is variation in the use of gastrectomy and chemotherapy in patients with metastatic gastric cancer, and subsequent differences in survival.
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| 4. |
- Fremling, Mikael, et al.
(författare)
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Energy projection and modified Laughlin states
- 2016
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Ingår i: Physical Review B. - 2469-9950 .- 2469-9969. ; 93:23
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Tidskriftsartikel (refereegranskat)abstract
- We develop a method to efficiently calculate trial wave functions for quantum Hall systems which involve projection onto the lowest Landau level. The method essentially replaces the lowest Landau level projection by projection onto the M lowest eigenstates of a suitably chosen Hamiltonian acting within the lowest Landau level. The resulting energy projection is a controlled approximation to the exact lowest Landau level projection which improves with increasing M. It allows us to study the projected trial wave functions for system sizes close to the maximal sizes that can be reached by exact diagonalization and can be straightforwardly applied in any geometry. As a first application and test case, we study a class of trial wave functions first proposed by Girvin and Jach [Girvin and Jach, Phys. Rev. B 29, 5617 (1984)], which are modifications of the Laughlin states involving a single real parameter. While these modified Laughlin states probably represent the same universality class exemplified by the Laughlin wave functions, we show by extensive numerical work for systems on the sphere and torus that they provide a significant improvement of the variational energy, overlap with the exact wave function and properties of the entanglement spectrum.
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| 8. |
- Eichenlaub, Manuel, et al.
(författare)
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Comparator Data Characteristics and Testing Procedures for the Clinical Performance Evaluation of Continuous Glucose Monitoring Systems
- 2024
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Ingår i: Diabetes Technology & Therapeutics. - : Mary Ann Liebert. - 1520-9156 .- 1557-8593. ; 26:4, s. 263-275
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Tidskriftsartikel (refereegranskat)abstract
- Comparing the performance of different continuous glucose monitoring (CGM) systems is challenging due to the lack of comprehensive guidelines for clinical study design. In particular, the absence of concise requirements for the distribution of comparator (reference) blood glucose (BG) concentrations and their rate of change (RoC), that are used to evaluate CGM performance, impairs comparability. For this article, several experts in the field of CGM performance testing have collaborated to propose characteristics of the distribution of comparator measurements that should be collected during CGM performance testing. Specifically, it is proposed that at least 7.5% of comparator BG concentrations are <70 mg/dL (3.9 mmol/L) and >300 mg/dL (16.7 mmol/L), respectively and that at least 7.5% of BG-RoC combinations indicate fast BG changes with impending hypo- or hyperglycemia, respectively. These proposed characteristics of the comparator data can facilitate the harmonization of testing conditions across different studies and CGM systems and ensure that the most relevant scenarios representing real-life situations are established during performance testing. In addition, a study protocol and testing procedure for the manipulation of glucose levels is suggested that enables the collection of comparator data with these characteristics. This work is an important step towards establishing a future standard for the performance evaluation of CGM systems.
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| 9. |
- Freckmann, Guido, et al.
(författare)
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Clinical Performance Evaluation of Continuous Glucose Monitoring Systems : A Scoping Review and Recommendations for Reporting
- 2023
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Ingår i: Journal of Diabetes Science and Technology. - : Sage Publications. - 1932-2968. ; 17:6, s. 1506-1526
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Forskningsöversikt (refereegranskat)abstract
- The use of different approaches for design and results presentation of studies for the clinical performance evaluation of continuous glucose monitoring (CGM) systems has long been recognized as a major challenge in comparing their results. However, a comprehensive characterization of the variability in study designs is currently unavailable. This article presents a scoping review of clinical CGM performance evaluations published between 2002 and 2022. Specifically, this review quantifies the prevalence of numerous options associated with various aspects of study design, including subject population, comparator (reference) method selection, testing procedures, and statistical accuracy evaluation. We found that there is a large variability in nearly all of those aspects and, in particular, in the characteristics of the comparator measurements. Furthermore, these characteristics as well as other crucial aspects of study design are often not reported in sufficient detail to allow an informed interpretation of study results. We therefore provide recommendations for reporting the general study design, CGM system use, comparator measurement approach, testing procedures, and data analysis/statistical performance evaluation. Additionally, this review aims to serve as a foundation for the development of a standardized CGM performance evaluation procedure, thereby supporting the goals and objectives of the Working Group on CGM established by the Scientific Division of the International Federation of Clinical Chemistry and Laboratory Medicine.
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| 11. |
- Van Slingerland, Krista J, et al.
(författare)
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Canadian Centre for Mental Health and Sport (CCMHS) Position Statement : Principles of Mental Health in Competitive and High-Performance Sport.
- 2019
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Ingår i: Clinical Journal of Sports Medicine. - : Wolters Kluwer. - 1050-642X .- 1536-3724. ; 29:3, s. 173-180
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Tidskriftsartikel (refereegranskat)abstract
- The brave decision made by many Canadian athletes to share their experience with mental illness has fed a growing dialogue surrounding mental health in competitive and high-performance sport. To affect real change for individuals, sport culture must change to meet demands for psychologically safe, supportive, and accepting sport environments. This position statement addresses mental health in competitive and high-performance sport in Canada, presenting solutions to current challenges and laying a foundation for a unified address of mental health by the Canadian sport community. The paper emerged from the first phase of a multidisciplinary Participatory Action Research (PAR) project, in which a sport-focused mental health care model housed within the Canadian Centre for Mental Health and Sport (CCMHS) is currently being designed, implemented, and evaluated by a team of 20 stakeholders, in collaboration with several community partners and advisors.
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| 12. |
- Van Slingerland, Krista J., et al.
(författare)
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Collaboratively designing the Canadian Centre for Mental Health and Sport (CCMHS) using Group Concept Mapping
- 2021
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Ingår i: Journal of Applied Sport Psychology. - : Routledge. - 1041-3200 .- 1533-1571. ; 33:1, s. 98-122
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Tidskriftsartikel (refereegranskat)abstract
- There are special considerations and challenges involved in diagnosing and treating mental illnesses in athletes (Glick & Horsfall, 2009). However, very few clinical psychologists and psychiatrists in Canada specialize in sport, representing a significant gap in mental health care service provision for this population. In this study, a group of expert sport and mental health stakeholders (n?=?17) employed a Participatory Action Research approach to design a specialized sport-focused mental health care model integrated within the Canadian Centre for Mental Health in Sport (CCMHS). Stakeholders engaged in focus group discussions to perform an environmental scan of the Canadian sport and mental health care contexts that laid the foundation for a group concept mapping (GCM) exercise. Using the Concepts Systems software, stakeholders individually produced statements that described the elements to include in a sport-specific mental health care model implemented within the CCMHS. A total of 106 unique statements were organized into 6 themed clusters, focusing on: (1) service delivery [40 statements], (2) communications and promotion [20 statements], (3) business, policy, and operations [19 statements], (4) partnerships [9 statements], (5) research [6 statements], and (6) education and training [6 statements]. These findings were operationalized to establish a sport-centered mental health care model and the CCMHS itself - the first Centre of its kind in Canada. GCM is seldom used to conduct sport research, thus the validity and reliability of this methodology was assessed.Lay Summary: In this study, 17 sport and mental health expert stakeholders participated in group concept mapping to design a sport-focused mental health care delivery model. The group produced 106 unique statements that were organized into six strategic priority areas and operationalized to establish the Canadian Centre for Mental Health and Sport.
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