| 1. |
- Kanai, M, et al.
(författare)
-
- 2023
-
swepub:Mat__t
|
|
| 2. |
- Niemi, MEK, et al.
(författare)
-
- 2021
-
swepub:Mat__t
|
|
| 3. |
- Mishra, A., et al.
(författare)
-
Stroke genetics informs drug discovery and risk prediction across ancestries
- 2022
-
Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 611, s. 115-123
-
Tidskriftsartikel (refereegranskat)abstract
- Previous genome-wide association studies (GWASs) of stroke - the second leading cause of death worldwide - were conducted predominantly in populations of European ancestry(1,2). Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals, 87% of the primary stroke risk loci and 60% of the secondary stroke risk loci were replicated (P < 0.05). Effect sizes were highly correlated across ancestries. Cross-ancestry fine-mapping, in silico mutagenesis analysis(3), and transcriptome-wide and proteome-wide association analyses revealed putative causal genes (such as SH3PXD2A and FURIN) and variants (such as at GRK5 and NOS3). Using a three-pronged approach(4), we provide genetic evidence for putative drug effects, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as possible targets, with drugs already under investigation for stroke for F11 and PROC. A polygenic score integrating cross-ancestry and ancestry-specific stroke GWASs with vascular-risk factor GWASs (integrative polygenic scores) strongly predicted ischaemic stroke in populations of European, East Asian and African ancestry(5). Stroke genetic risk scores were predictive of ischaemic stroke independent of clinical risk factors in 52,600 clinical-trial participants with cardiometabolic disease. Our results provide insights to inform biology, reveal potential drug targets and derive genetic risk prediction tools across ancestries.
|
|
| 4. |
- Jones, Benedict C, et al.
(författare)
-
To which world regions does the valence-dominance model of social perception apply?
- 2021
-
Ingår i: Nature Human Behaviour. - : Springer Science and Business Media LLC. - 2397-3374. ; 5:1, s. 159-169
-
Tidskriftsartikel (refereegranskat)abstract
- Over the past 10 years, Oosterhof and Todorov's valence-dominance model has emerged as the most prominent account of how people evaluate faces on social dimensions. In this model, two dimensions (valence and dominance) underpin social judgements of faces. Because this model has primarily been developed and tested in Western regions, it is unclear whether these findings apply to other regions. We addressed this question by replicating Oosterhof and Todorov's methodology across 11 world regions, 41 countries and 11,570 participants. When we used Oosterhof and Todorov's original analysis strategy, the valence-dominance model generalized across regions. When we used an alternative methodology to allow for correlated dimensions, we observed much less generalization. Collectively, these results suggest that, while the valence-dominance model generalizes very well across regions when dimensions are forced to be orthogonal, regional differences are revealed when we use different extraction methods and correlate and rotate the dimension reduction solution. PROTOCOL REGISTRATION: The stage 1 protocol for this Registered Report was accepted in principle on 5 November 2018. The protocol, as accepted by the journal, can be found at https://doi.org/10.6084/m9.figshare.7611443.v1 .
|
|
| 5. |
- Sermeus, W, et al.
(författare)
-
A workplace organisational intervention to improve hospital nurses' and physicians' mental health: study protocol for the Magnet4Europe wait list cluster randomised controlled trial
- 2022
-
Ingår i: BMJ open. - : BMJ. - 2044-6055. ; 12:7, s. e059159-
-
Tidskriftsartikel (refereegranskat)abstract
- The increasing burden of mental distress reported by healthcare professionals is a matter of serious concern and there is a growing recognition of the role of the workplace in creating this problem. Magnet hospitals, a model shown to attract and retain staff in US research, creates positive work environments that aim to support the well-being of healthcare professionals.Methods and analysisMagnet4Europe is a cluster randomised controlled trial, with wait list controls, designed to evaluate the effects of organisational redesign, based on the Magnet model, on nurses’ and physicians’ well-being in general acute care hospitals, using a multicomponent implementation strategy. The study will be conducted in more than 60 general acute care hospitals in Belgium, England, Germany, Ireland, Norway and Sweden. The primary outcome is burnout among nurses and physicians, assessed in longitudinal surveys of nurses and physicians at participating hospitals. Additional data will be collected from them on perceived work environments, patient safety and patient quality of care and will be triangulated with data from medical records, including case mix-adjusted in-hospital mortality. The process of implementation will be evaluated using qualitative data from focus group and key informant interviews.Ethics and disseminationThis study was approved by the Ethics Committee Research UZ/KU Leuven, Belgium; additionally, ethics approval is obtained in all other participating countries either through a central or decentral authority. Findings will be disseminated at conferences, through peer-reviewed manuscripts and via social media.Trial registration numberISRCTN10196901.
|
|
| 6. |
|
|
| 7. |
- Reynolds, Ben C., et al.
(författare)
-
An inter-laboratory comparison of Si isotope reference materials
- 2007
-
Ingår i: Journal of Analytical Atomic Spectrometry. - : Royal Society of Chemistry (RSC). - 0267-9477 .- 1364-5544. ; 22:5, s. 561-568
-
Tidskriftsartikel (refereegranskat)abstract
- Three Si isotope materials have been used for an inter-laboratory comparison exercise to ensure reproducibility between international laboratories investigating natural Si isotope variations using a variety of chemical preparation methods and mass spectrometric techniques. These proposed standard reference materials are (i) IRMM-018 (a SiO2 standard), (ii) Big-Batch (a fractionated SiO2 material prepared at the University of California Santa Barbara), and (iii) Diatomite (a natural diatomite sample originally deposited as marine biogenic opal). All analyses are compared with the international Si standard NBS28 (RM8546) and are in reasonable agreement (<+/- 0.22 parts per thousand. 1 sigma(SD) delta Si-30) given the different measurement techniques involved. These methods include both acid and alkaline dissolution/fusion, Si separation using cation exchange, selective co-precipitation, and gas-source versus plasma-ionization (high and low resolution) mass-spectrometric techniques. The average delta Si-30 for Diatomite, IRMM-018, and Big-Batch are + 1.26 parts per thousand, -1.65 parts per thousand and -10.48 parts per thousand, respectively, with corresponding delta Si-9 values of + 0.64 parts per thousand, -0.85 parts per thousand and -5.35 parts per thousand for the same standards, respectively. For the most fractionated standard (Big-Batch), results demonstrate a kinetic mass-dependent fractionation effect for atomic Si (i.e., delta Si-29 similar to 0.51 x delta Si-30). There is almost no statistical difference between the mean values obtained by each participating laboratory, with the notable exception of the IRMM-018 standard. This effect could be caused by heterogeneity or contamination of this standard. The results for the other two standards indicate that data sets produced using any of the methods employed in this study will have similar precision and differences are limited to 0.2 parts per thousand in mean delta Si-30 values for a given sample between laboratories, or differences of 0.13 parts per thousand. in mean delta Si-29 values.
|
|
| 8. |
- Reynolds, Ben C., et al.
(författare)
-
An inter-laboratory comparison of Si isotope reference materials
- 2007
-
Ingår i: Journal of Analytical Atomic Spectrometry. - : Elsevier BV. - 0267-9477 .- 1364-5544. ; 22:5, s. 561-568
-
Tidskriftsartikel (refereegranskat)abstract
- Three Si isotope materials have been used for an inter-laboratory comparison exercise to ensure reproducibility between international laboratories investigating natural Si isotope variations using a variety of chemical preparation methods and mass spectrometric techniques. These proposed standard reference materials are (i) IRMM-018 (a SiO2 standard), (ii) Big-Batch (a fractionated SiO2 material prepared at the University of California Santa Barbara), and (iii) Diatomite (a natural diatomite sample originally deposited as marine biogenic opal). All analyses are compared with the international Si standard NBS28 (RM8546) and are in reasonable agreement (<+/- 0.22 parts per thousand. 1 sigma(SD) delta Si-30) given the different measurement techniques involved. These methods include both acid and alkaline dissolution/fusion, Si separation using cation exchange, selective co-precipitation, and gas-source versus plasma-ionization (high and low resolution) mass-spectrometric techniques. The average delta Si-30 for Diatomite, IRMM-018, and Big-Batch are + 1.26 parts per thousand, -1.65 parts per thousand and -10.48 parts per thousand, respectively, with corresponding delta Si-9 values of + 0.64 parts per thousand, -0.85 parts per thousand and -5.35 parts per thousand for the same standards, respectively. For the most fractionated standard (Big-Batch), results demonstrate a kinetic mass-dependent fractionation effect for atomic Si (i.e., delta Si-29 similar to 0.51 x delta Si-30). There is almost no statistical difference between the mean values obtained by each participating laboratory, with the notable exception of the IRMM-018 standard. This effect could be caused by heterogeneity or contamination of this standard. The results for the other two standards indicate that data sets produced using any of the methods employed in this study will have similar precision and differences are limited to 0.2 parts per thousand in mean delta Si-30 values for a given sample between laboratories, or differences of 0.13 parts per thousand. in mean delta Si-29 values.
|
|
| 9. |
- van Buul, Laura W, et al.
(författare)
-
The Development of a Decision Tool for the Empiric Treatment of Suspected Urinary Tract Infection in Frail Older Adults: A Delphi Consensus Procedure.
- 2018
-
Ingår i: Journal of the American Medical Directors Association. - : Elsevier BV. - 1538-9375 .- 1525-8610. ; 19:9, s. 757-764
-
Tidskriftsartikel (refereegranskat)abstract
- Nonspecific signs and symptoms combined with positive urinalysis results frequently trigger antibiotic therapy in frail older adults. However, there is limited evidence about which signs and symptoms indicate urinary tract infection (UTI) in this population. We aimed to find consensus among an international expert panel on which signs and symptoms, commonly attributed to UTI, should and should not lead to antibiotic prescribing in frail older adults, and to integrate these findings into a decision tool for the empiric treatment of suspected UTI in this population.A Delphi consensus procedure.An international panel of practitioners recognized as experts in the field of UTI in frail older patients.In 4 questionnaire rounds, the panel (1) evaluated the likelihood that individual signs and symptoms are caused by UTI, (2) indicated whether they would prescribe antibiotics empirically for combinations of signs and symptoms, and (3) provided feedback on a draft decision tool.Experts agreed that the majority of nonspecific signs and symptoms should be evaluated for other causes instead of being attributed to UTI and that urinalysis should not influence treatment decisions unless both nitrite and leukocyte esterase are negative. These and other findings were incorporated into a decision tool for the empiric treatment for suspected UTI in frail older adults with and without an indwelling urinary catheter.A decision tool for suspected UTI in frail older adults was developed based on consensus among an international expert panel. Studies are needed to evaluate whether this decision tool is effective in reaching its aim: the improvement of diagnostic evaluation and treatment for suspected UTI in frail older adults.
|
|
| 10. |
|
|
| 11. |
- Jonsson, C. E., et al.
(författare)
-
High-resolution diatom d18O records from two sub-Arctic high-altitude lakes in the Swedish Scandes
-
Ingår i: Journal of Quaternary Science. - 0267-8179 .- 1099-1417.
-
Tidskriftsartikel (refereegranskat)abstract
- Waters from high altitude alpine lakes are mainly recharged by meteoric water. Because of seasonal variations in precipitation and temperature, and relatively short hydraulic residence times, most high altitude lakes have lake water isotopic compositions (δ18Olake) that fluctuate due to seasonality in water balance processes. Input from snowmelt, in particular, has a significant role in determining lake water d18O. Here we compare two high resolution δ18Odiatom records from lake sediments in the Swedish Scandes with instrumental data from the last century obtained from nearby meteorological stations. The time period AD 1900 to AD 1990 is characterized by an increase in winter precipitation and high winter/summer precipitation ratios and this is recorded in δ18Odiatom as decreasing trends. Lowest δ18Odiatom values and highest amount of winter precipitation are found around AD 1990 when the winter North Atlantic Oscillation index was above +2. We conclude that for the last 150 years the main factor affecting the δ18Odiatom signal in these sub-Arctic high altitude lakes with short residence times has been changes in amount of winter precipitation and that δ18Odiatom derived from high altitude lakes in the Swedish Scandes can be used as a winter precipitation proxy.
|
|
| 12. |
- Jonsson, Christina E., et al.
(författare)
-
High-resolution diatom delta O-18 records, from the last 150 years, reflecting changes in amount of winter precipitation in two sub-Arctic high-altitude lakes in the Swedish Scandes
- 2010
-
Ingår i: Journal of Quaternary Science. - : Wiley. - 0267-8179 .- 1099-1417. ; 25:6, s. 918-930
-
Tidskriftsartikel (refereegranskat)abstract
- Waters from high-altitude alpine lakes are mainly recharged by meteoric water. Because of seasonal variations in precipitation and temperature and relatively short hydraulic residence times, most high-altitude lakes have lake water isotopic compositions (delta O-18(lake)) that fluctuate due to seasonality in water balance processes. Input from snowmelt, in particular, has a significant role in determining lake water delta O-18. Here we compare two high-resolution delta O-18(diatom) records from lake sediments in the Swedish Scandes with instrumental data from the last century obtained from nearby meteorological stations. The time period AD 1900-1990 is characterised by an increase in winter precipitation and high winter/summer precipitation ratios and this is recorded in delta O-18(diatom) as decreasing trends. Lowest delta O-18(diatom) values and highest amount of winter precipitation are found around AD 1990 when the winter North Atlantic Oscillation index was above +2. We conclude that for the last 150 a the main factor affecting the delta O-18(diatom) signal in these sub-Arctic high-altitude lakes with short residence times has been changes in amount of winter precipitation and that delta O-18(diatom) derived from high-altitude lakes in the Swedish Scandes can be used as a winter precipitation proxy.
|
|
| 13. |
- Jonsson, Christina E, et al.
(författare)
-
High resolution diatom δ18O records from two sub-Arctic high altitude lakes in the Swedish Scandes
- 2010
-
Ingår i: Journal of Quaternary Science. - : Wiley. - 0267-8179 .- 1099-1417. ; 25:6, s. 918-930
-
Tidskriftsartikel (refereegranskat)abstract
- Waters from high-altitude alpine lakes are mainly recharged by meteoric water. Because of seasonal variations in precipitation and temperature and relatively short hydraulic residence times, most high-altitude lakes have lake water isotopic compositions (δ18Olake) that fluctuate due to seasonality in water balance processes. Input from snowmelt, in particular, has a significant role in determining lake water δ18O. Here we compare two high-resolution δ18Odiatom records from lake sediments in the Swedish Scandes with instrumental data from the last century obtained from nearby meteorological stations. The time period AD 1900–1990 is characterised by an increase in winter precipitation and high winter/summer precipitation ratios and this is recorded in δ18Odiatom as decreasing trends. Lowest δ18Odiatom values and highest amount of winter precipitation are found around AD 1990 when the winter North Atlantic Oscillation index was above +2. We conclude that for the last 150 a the main factor affecting the δ18Odiatom signal in these sub-Arctic high-altitude lakes with short residence times has been changes in amount of winter precipitation and that δ18Odiatom derived from high-altitude lakes in the Swedish Scandes can be used as a winter precipitation proxy. Copyright © 2010 John Wiley & Sons, Ltd.
|
|
| 14. |
- Rosqvist, Gunhild C., et al.
(författare)
-
Shifts in precipitation during the last millennium in northern Scandinavia from lacustrine isotope records
- 2013
-
Ingår i: Quaternary Science Reviews. - : Elsevier BV. - 0277-3791 .- 1873-457X. ; 66, s. 22-34
-
Tidskriftsartikel (refereegranskat)abstract
- Here we present delta P-18(diatom) data from two high-latitude lakes; one has short residence time and a water isotopic composition (delta O-18(lake)) that fluctuate due to seasonal variations in precipitation and temperature, and the other has delta O-18(lake) that is influenced by longer lake water residence times and evaporation. The delta O-18(diatom) records reveal common responses to precipitation forcing over the past millennium. Relatively wet summers are inferred from delta O-18(diatom) between 1000 and 1080 AD, 1300 and 1440 AD, and during the early 19th century, coincided with periods of high cloud cover inferred from tree-ring carbon isotopes, and other data for high Arctic Oscillation index. While relatively dry summers with increasing influence of winter snow are indicated between 1600 and 1750 AD. The co-response between carbon isotopes in trees and oxygen isotopes in diatoms strengthens the relationship between cloud cover and precipitation and the hypothesis that these changes were the result of significant regional shifts in atmospheric circulation.
|
|
| 15. |
|
|
| 16. |
|
|
| 17. |
|
|
| 18. |
|
|
| 19. |
|
|
| 20. |
|
|
| 21. |
- Barletta, V, et al.
(författare)
-
Quantitative 7-Tesla Imaging of Cortical Myelin Changes in Early Multiple Sclerosis
- 2021
-
Ingår i: Frontiers in neurology. - : Frontiers Media SA. - 1664-2295. ; 12, s. 714820-
-
Tidskriftsartikel (refereegranskat)abstract
- Cortical demyelination occurs early in multiple sclerosis (MS) and relates to disease outcome. The brain cortex has endogenous propensity for remyelination as proven from histopathology study. In this study, we aimed at characterizing cortical microstructural abnormalities related to myelin content by applying a novel quantitative MRI technique in early MS. A combined myelin estimation (CME) cortical map was obtained from quantitative 7-Tesla (7T) T2* and T1 acquisitions in 25 patients with early MS and 19 healthy volunteers. Cortical lesions in MS patients were classified based on their myelin content by comparison with CME values in healthy controls as demyelinated, partially demyelinated, or non-demyelinated. At follow-up, we registered changes in cortical lesions as increased, decreased, or stable CME. Vertex-wise analysis compared cortical CME in the normal-appearing cortex in 25 MS patients vs. 19 healthy controls at baseline and investigated longitudinal changes at 1 year in 10 MS patients. Measurements from the neurite orientation dispersion and density imaging (NODDI) diffusion model were obtained to account for cortical neurite/dendrite loss at baseline and follow-up. Finally, CME maps were correlated with clinical metrics. CME was overall low in cortical lesions (p = 0.03) and several normal-appearing cortical areas (p < 0.05) in the absence of NODDI abnormalities. Individual cortical lesion analysis revealed, however, heterogeneous CME patterns from extensive to partial or absent demyelination. At follow-up, CME overall decreased in cortical lesions and non-lesioned cortex, with few areas showing an increase (p < 0.05). Cortical CME maps correlated with processing speed in several areas across the cortex. In conclusion, CME allows detection of cortical microstructural changes related to coexisting demyelination and remyelination since the early phases of MS, and shows to be more sensitive than NODDI and relates to cognitive performance.
|
|
| 22. |
- Ge, Z, et al.
(författare)
-
Aberrant ARID5B expression and its association with Ikaros dysfunction in acute lymphoblastic leukemia
- 2018
-
Ingår i: Oncogenesis. - : Springer Science and Business Media LLC. - 2157-9024. ; 7:11, s. 84-
-
Tidskriftsartikel (refereegranskat)abstract
- Mutations and single nucleotide polymorphisms of AT-rich interactive domain-containing protein 5B (ARID5B) are involved in the oncogenesis of acute lymphoblastic leukemia (ALL) and treatment outcomes. However, ARID5B expression and clinical significance in ALL remain unclear. We found ARID5B is significantly down-regulated in ALL compared to healthy bone marrow controls. ARID5B also interacts with PHD finger protein 2 (PHF2). Low expression of ARID5B (ARID5Blow) or ARID5B and PHF2 (ARID5BlowPHF2low) is correlated with the markers of cell proliferation and poor prognosis in ALL patients. Ikaros directly regulates ARID5B expression in ALL. Restoring Ikaros function by Casein Kinase II inhibition also promotes ARID5B expression through recruitment of trimethylation of lysine 4 on histone H3 (H3K4me3) at its promoter region. In summary, our data show that aberrant expression of ARID5B and PHF2 is related to leukemic cell proliferation and several poor prognostic markers. Our data indicate ARID5Blow expression, particularly ARID5BlowPHF2low expression, is linked to Ikaros dysfunction and involved in the oncogenic effect of high-risk ALL, which may represent a high-risk subgroup of ALL.
|
|
| 23. |
- Granberg, T, et al.
(författare)
-
Corrigendum
- 2018
-
Ingår i: Brain : a journal of neurology. - : Oxford University Press (OUP). - 1460-2156. ; 141:2, s. e14-
-
Tidskriftsartikel (refereegranskat)
|
|
| 24. |
|
|
| 25. |
|
|
| 26. |
|
|
| 27. |
- Herranz, E, et al.
(författare)
-
Profiles of cortical inflammation in multiple sclerosis by 11C-PBR28 MR-PET and 7 Tesla imaging
- 2020
-
Ingår i: Multiple sclerosis (Houndmills, Basingstoke, England). - : SAGE Publications. - 1477-0970 .- 1352-4585. ; 26:12, s. 1497-1509
-
Tidskriftsartikel (refereegranskat)abstract
- Neuroinflammation with microglia activation is thought to be closely related to cortical multiple sclerosis (MS) lesion pathogenesis. Objective: Using 11C-PBR28 and 7 Tesla (7T) imaging, we assessed in 9 relapsing–remitting multiple sclerosis (RRMS) and 10 secondary progressive multiple sclerosis (SPMS) patients the following: (1) microglia activation in lesioned and normal-appearing cortex, (2) cortical lesion inflammatory profiles, and (3) the relationship between neuroinflammation and cortical integrity. Methods: Mean 11C-PBR28 uptake was measured in focal cortical lesions, cortical areas with 7T quantitative T2* (q-T2*) abnormalities, and normal-appearing cortex. The relative difference in cortical 11C-PBR28 uptake between patients and 14 controls was used to classify cortical lesions as either active or inactive. Disease burden was investigated according to cortical lesion inflammatory profiles. The relation between q-T2* and 11C-PBR28 uptake along the cortex was assessed. Results: 11C-PBR28 uptake was abnormally high in cortical lesions in RRMS and SPMS; in SPMS, tracer uptake was significantly increased also in normal-appearing cortex. 11C-PBR28 uptake and q-T2* correlated positively in many cortical areas, negatively in some regions. Patients with high cortical lesion inflammation had worse clinical outcome and higher intracortical lesion burden than patients with low inflammation. Conclusion: 11C-PBR28 and 7T imaging reveal distinct profiles of cortical inflammation in MS, which are related to disease burden.
|
|
| 28. |
- Jonsson, C. E., et al.
(författare)
-
Two diatom oxygen isotope records from Naimakka in northern Fennoscandia: implications for Holocene palaeohydrology and atmospheric circulation dynamics
-
Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- This study present past changes in lake water oxygen isotope composition (δ18Olakew) calculated from diatom oxygen isotope composition (δ18Odiatom) from two lake sediment records. The two sediment sequences (9500 and 2800 years) are from open-basin lakes, although with different hydrologies, and are located close to a meteorological station in Naimakka, Northern Fennoscandia. The isotope composition of lake waters was analysed to determine the modern regional hydrological setting. Our results show that changes in the isotope composition of precipitation (δ18Op) is the primary forcing mechanism decreasing or increasing the δ18Olakew values in both lakes. Changes in the isotope signals are interpreted as reflecting regional variations in atmospheric circulation and climatic seasonality. δ18Odiatom from Lake Keitjoru, covering the last 9500 years, shows a depletion trend of 1.3‰ from c. 8000 until around 1500 cal yr BP. This decrease is thought to be due to a long term decrease in the influence of a zonal airflow (strong westerlies, relatively high δ18Op) over Fennoscandia in favor of an increasing proportion of colder meridional airflow (weak westerlies, lower δ18Op) from the north. A synchronous shift to lower δ18O values was recorded in Lake Keitjoru and lake Oikojärvi around 700-600 cal yr BP (~AD 1250-1350), a time when European climate deteriorated into the “Little Ice Age”. We argue that a circulation pattern dominated by meridional airflow, with reduced westerlies over Northern Fennoscandia and high amounts of winter precipitation from southeast or north, replaced a zonal atmospheric circulation pattern at this time. The δ18Odiatom minima c. 400 and 50 cal yr BP (~AD 1550 and AD 1900) is likely also a response to shifts in circulation, which is also seen in lower summer temperatures at that time recorded in tree-rings and from pollen data. The fact that the same isotope shifts have been detected in δ18O records from hydrological different lakes lends support to our conclusion that these records reflect variations in atmospheric circulation pattern.
|
|
| 29. |
|
|
| 30. |
|
|
| 31. |
|
|
| 32. |
|
|
| 33. |
|
|
| 34. |
|
|
| 35. |
|
|
