| 1. |
- Rodriguez, D., et al.
(författare)
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MATS and LaSpec : High-precision experiments using ion traps and lasers at FAIR
- 2010
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Ingår i: The European physical journal. Special topics. - : Springer Science and Business Media LLC. - 1951-6355 .- 1951-6401. ; 183, s. 1-123
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Forskningsöversikt (refereegranskat)abstract
- Nuclear ground state properties including mass, charge radii, spins and moments can be determined by applying atomic physics techniques such as Penning-trap based mass spectrometry and laser spectroscopy. The MATS and LaSpec setups at the low-energy beamline at FAIR will allow us to extend the knowledge of these properties further into the region far from stability. The mass and its inherent connection with the nuclear binding energy is a fundamental property of a nuclide, a unique ""fingerprint"". Thus, precise mass values are important for a variety of applications, ranging from nuclear-structure studies like the investigation of shell closures and the onset of deformation, tests of nuclear mass models and mass formulas, to tests of the weak interaction and of the Standard Model. The required relative accuracy ranges from 10(-5) to below 10(-8) for radionuclides, which most often have half-lives well below 1 s. Substantial progress in Penning trap mass spectrometry has made this method a prime choice for precision measurements on rare isotopes. The technique has the potential to provide high accuracy and sensitivity even for very short-lived nuclides. Furthermore, ion traps can be used for precision decay studies and offer advantages over existing methods. With MATS (Precision Measurements of very short-lived nuclei using an Advanced Trapping System for highly-charged ions) at FAIR we aim to apply several techniques to very short-lived radionuclides: High-accuracy mass measurements, in-trap conversion electron and alpha spectroscopy, and trap-assisted spectroscopy. The experimental setup of MATS is a unique combination of an electron beam ion trap for charge breeding, ion traps for beam preparation, and a high-precision Penning trap system for mass measurements and decay studies. For the mass measurements, MATS offers both a high accuracy and a high sensitivity. A relative mass uncertainty of 10(-9) can be reached by employing highly-charged ions and a non-destructive Fourier-Transform Ion-Cyclotron-Resonance (FT-ICR) detection technique on single stored ions. This accuracy limit is important for fundamental interaction tests, but also allows for the study of the fine structure of the nuclear mass surface with unprecedented accuracy, whenever required. The use of the FT-ICR technique provides true single ion sensitivity. This is essential to access isotopes that are produced with minimum rates which are very often the most interesting ones. Instead of pushing for highest accuracy, the high charge state of the ions can also be used to reduce the storage time of the ions, hence making measurements on even shorter-lived isotopes possible. Decay studies in ion traps will become possible with MATS. Novel spectroscopic tools for in-trap high-resolution conversion-electron and charged-particle spectroscopy from carrier-free sources will be developed, aiming e. g. at the measurements of quadrupole moments and E0 strengths. With the possibility of both high-accuracy mass measurements of the shortest-lived isotopes and decay studies, the high sensitivity and accuracy potential of MATS is ideally suited for the study of very exotic nuclides that will only be produced at the FAIR facility. Laser spectroscopy of radioactive isotopes and isomers is an efficient and model-independent approach for the determination of nuclear ground and isomeric state properties. Hyperfine structures and isotope shifts in electronic transitions exhibit readily accessible information on the nuclear spin, magnetic dipole and electric quadrupole moments as well as root-mean-square charge radii. The dependencies of the hyperfine splitting and isotope shift on the nuclear moments and mean square nuclear charge radii are well known and the theoretical framework for the extraction of nuclear parameters is well established. These extracted parameters provide fundamental information on the structure of nuclei at the limits of stability. Vital information on both bulk and valence nuclear properties are derived and an exceptional sensitivity to changes in nuclear deformation is achieved. Laser spectroscopy provides the only mechanism for such studies in exotic systems and uniquely facilitates these studies in a model-independent manner. The accuracy of laser-spectroscopic-determined nuclear properties is very high. Requirements concerning production rates are moderate; collinear spectroscopy has been performed with production rates as few as 100 ions per second and laser-desorption resonance ionization mass spectroscopy (combined with beta-delayed neutron detection) has been achieved with rates of only a few atoms per second. This Technical Design Report describes a new Penning trap mass spectrometry setup as well as a number of complementary experimental devices for laser spectroscopy, which will provide a complete system with respect to the physics and isotopes that can be studied. Since MATS and LaSpec require high-quality low-energy beams, the two collaborations have a common beamline to stop the radioactive beam of in-flight produced isotopes and prepare them in a suitable way for transfer to the MATS and LaSpec setups, respectively.
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| 12. |
- Waschitz, Y., et al.
(författare)
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Independent isotopic fission yields of Cf-252 spontaneous fission via mass measurements at the FRS Ion Catcher
- 2023
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Ingår i: 15th International Conference on Nuclear Data for Science and Technology, ND2022. - : EDP Sciences.
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Konferensbidrag (refereegranskat)abstract
- We present first preliminary results of a novel method for measuring independent isotopic fission yields (IIFYs) of spontaneous fission (SF) via direct mass measurements, at the FRS Ion Catcher (FRS -IC) at GSI. Fission products were generated from a Cf-252 source installed in a cryogenic stopping cell, and were identified and counted with the multiple-reflection time-of-flight mass spectrometer (MR-TOR-MS) of the FRS-IC, utilizing well-established measurement and data analysis methods. The MR-TOR-MS resolves isobars unambiguously, even with limited statistics, and its non-scanning nature ensures minimal relative systematic uncertainties amongst fission products. The analysis for extracting IIFYs includes isotope-dependent efficiency corrections for all components of the FRS -IC. In particular, we applied a self-consistent technique that takes into account the element-dependent survival efficiencies in the CSC, due to chemical reactions with the buffer gas. Our IIFY results, which cover several tens of fission products in the less -accessible high-mass peak (Z = 56 to 63) down to fission yields at the level of 10(-5), are generally similar to those of the nuclear database ENDF/B-VII.O. Nevertheless, they reveal some structures that are not observed in the database smooth trends. These are the first results of a planned campaign to investigate IIFY distributions of spontaneous fission at the FRS-IC. Upcoming experiments will extend our results to wider Z and N ranges, lower fission yields, and other spontaneously-fissioning actinides.
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| 14. |
- Andreasson, M., et al.
(författare)
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Altered CSF levels of monoamines in hereditary spastic paraparesis 10 A case series
- 2019
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Ingår i: Neurology-Genetics. - : Ovid Technologies (Wolters Kluwer Health). - 2376-7839. ; 5:4
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Tidskriftsartikel (refereegranskat)abstract
- Objective To perform a comprehensive clinical characterization and biochemical CSF profile analyses in 2 Swedish families with hereditary spastic paraparesis (HSP) 10 (SPG10) caused by 2 different mutations in the neuronal kinesin heavy chain gene (KIF5A). Methods Structured clinical assessment, genetic studies, and neuroradiologic and electrophysiological evaluations were performed in 4 patients from 2 families with SPG10. Additional CSF analysis was conducted in 3 patients with regard to levels of neurodegenerative markers and monoamine metabolism. Results All patients exhibited a complex form of HSP with a mild to moderate concurrent axonal polyneuropathy. The heterozygous missense mutations c.767A>G and c.967C>T in KIF5A were found. Wide intrafamilial phenotype variability was evident in both families. CSF analysis demonstrated a mild elevation of neurofilament light (NFL) chain in the patient with longest disease duration. Unexpectedly, all patients exhibited increased levels of the dopamine metabolite, homovanillic acid, whereas decreased levels of the noradrenergic metabolite, 3-methoxy-4-hydroxyphenylglycol, were found in 2 of 3 patients. Conclusions We report on CSF abnormalities in SPG10, demonstrating that NFL elevation is not a mandatory finding but may appear after long-standing disease. Impaired transportation of synaptic proteins may be a possible explanation for the increased dopaminergic turnover and noradrenergic deficiency identified. The reasons for these selective abnormalities, unrelated to obvious clinical features, remain to be explained. Our findings need further confirmation in larger cohorts of patients harboring KIF5A mutations.
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| 15. |
- Andreasson, M., et al.
(författare)
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Parkinson's disease with restless legs syndrome-an in vivo corneal confocal microscopy study
- 2021
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Ingår i: npj Parkinson's Disease. - : Springer Science and Business Media LLC. - 2373-8057. ; 7:1
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Tidskriftsartikel (refereegranskat)abstract
- Small fiber neuropathy (SFN) has been suggested as a trigger of restless legs syndrome (RLS). An increased prevalence of peripheral neuropathy has been demonstrated in Parkinson's disease (PD). We aimed to investigate, in a cross-sectional manner, whether SFN is overrepresented in PD patients with concurrent RLS relative to PD patients without RLS, using in vivo corneal confocal microscopy (IVCCM) and quantitative sensory testing (QST) as part of small fiber assessment. Study participants comprised of age- and sex-matched PD patients with (n = 21) and without RLS (n = 21), and controls (n = 13). Diagnosis of RLS was consolidated with the sensory suggested immobilization test. Assessments included nerve conduction studies (NCS), Utah Early Neuropathy Scale (UENS), QST, and IVCCM, with automated determination of corneal nerve fiber length (CNFL) and branch density (CNBD) from wide-area mosaics of the subbasal nerve plexus. Plasma neurofilament light (p-NfL) was determined as a measure of axonal degeneration. No significant differences were found between groups when comparing CNFL (p = 0.81), CNBD (p = 0.92), NCS (p = 0.82), and QST (minimum p = 0.54). UENS scores, however, differed significantly (p = 0.001), with post-hoc pairwise testing revealing higher scores in both PD groups relative to controls (p = 0.018 and p = 0.001). Analysis of all PD patients (n = 42) revealed a correlation between the duration of l-dopa therapy and CNBD (rho = -0.36, p = 0.022), and p-NfL correlated with UENS (rho = 0.35, p = 0.026) and NCS (rho = -0.51, p = 0.001). Small and large fiber neuropathy do not appear to be associated with RLS in PD. Whether peripheral small and/or large fiber pathology associates with central neurodegeneration in PD merits further longitudinal studies.
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| 16. |
- Andreasson, M, et al.
(författare)
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Polyneuropathy in Gaucher disease type 1 and 3 - a descriptive case series
- 2019
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Ingår i: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 9:1, s. 15358-
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Tidskriftsartikel (refereegranskat)abstract
- Polyneuropathy (PNP) has been reported to be a possible phenotypic feature in Gaucher disease type 1 (GD1), while less is known about PNP in type 3 (GD3). We performed a cross-sectional study, exploring PNP in a Swedish GD cohort. Clinical assessment and blood biochemistry were carried out in 8 patients with GD1 and 11 patients with GD3. In patients with symptoms or clinical findings indicative of PNP, nerve conduction studies and quantitative sensory testing were performed. Assessments were compared to historic controls. A subclinical small fiber neuropathy (SFN) was demonstrated in 2 of 8 patients in the significantly (p = 0,021) older GD1 cohort. A large fiber PNP was evident in an additional 3 GD1 patients but could not be ascribed as disease manifestation. No GD3 patients exhibited neurophysiological evidence of small or large fiber PNP attributed to GD3. Compared to historic controls, no significant group differences were evident with regard to neuropathy rating scores. In summary, our study does not support large fiber PNP as a prevalent manifestation of GD. SFN is a possible feature in GD1, although small sample size limits definite conclusions. Our study provides novel data, arguing against clinically significant small or large fiber PNP in GD3.
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| 21. |
- Kolhinen, V. S., et al.
(författare)
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Recommissioning of JYFLTRAP at the new IGISOL-4 facility
- 2013
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Ingår i: Nuclear Instruments and Methods in Physics Research Section B. - : Elsevier BV. - 0168-583X .- 1872-9584. ; 317:Part B, s. 506-509
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Tidskriftsartikel (refereegranskat)abstract
- The JYFLTRAP double Penning-trap system was moved to a new location along with the Ion Guide Isotope Separator On-line (IGISOL) facility at the Accelerator Laboratory of the University of Jyväskylä. The move made it possible to upgrade various parts of the facility. For example, separate beam lines for JYFLTRAP and the collinear laser spectroscopy station were constructed after the radio-frequency quadrupole cooler and buncher. In this contribution we give an overview of the new JYFLTRAP facility and results from the first stable ion-beam tests.
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| 22. |
- Minde, Jan, et al.
(författare)
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A novel NGFB point mutation : a phenotype study of heterozygous patients
- 2009
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Ingår i: Journal of Neurology, Neurosurgery and Psychiatry. - : BMJ Publishing Group Ltd. - 0022-3050 .- 1468-330X. ; 80:2, s. 188-195
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: A family with neurological findings similar to hereditary sensory and autonomic neuropathy type V having a point mutation in the nerve growth factor beta (NGFB) gene was recently described. The homozygous genotype gives disabling symptoms. The purpose of the present study was to evaluate the symptoms in heterozygous patients. METHODS: 26 patients heterozygous for the NGFB mutation (12 men, mean age 50 (13-90) years) were examined clinically and answered a health status questionnaire, including the Michigan Neuropathy Screening Instrument (MNSI). 28 relatives (15 men, mean age 44 (15-86) years) without the mutation served as controls in the clinical examination part. 23 of the heterozygotes were examined neurophysiologically and six heterozygous patients underwent a sural nerve biopsy. RESULTS: The heterozygous phenotype ranged from eight patients with Charcot arthropathy starting in adult age and associated with variable symptoms of neuropathy but without complete insensitivity to pain, anhidrosis or mental retardation, to 10 symptom free patients. There was no difference in MNSI between the young heterozygous cases (<55 years old) and the controls. Six of 23 heterozygous patients had impaired cutaneous thermal perception and 11 of 23 had signs of carpal tunnel syndrome. Sural nerve biopsies showed a moderate reduction of both small myelinated (Adelta) and unmyelinated (C) fibres. No apparent correlation of small fibre reduction to symptoms was found. CONCLUSIONS: The NGFB mutation in its heterozygous form results in a milder disease than in homozygotes, with a variable clinical picture, ranging from asymptomatic cases to those with Charcot arthropathy appearing in adult age. Particularly age, but perhaps lifestyle factors also, may influence the development of clinical polyneuropathy.
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| 31. |
- Al-Adili, Ali, et al.
(författare)
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Analysis of prompt fission neutrons in U-235(nth,f) and fission fragment distributions for the thermal neutron induced fission of U-234
- 2016
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Ingår i: CNR*15 - 5th International Workshop On Compound-Nuclear Reactions And Related Topics. - : EDP Sciences.
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Konferensbidrag (refereegranskat)abstract
- This paper presents the ongoing analysis of two fission experiments. Both projects are part of the collaboration between the nuclear reactions group at Uppsala and the JRC-IRMM. The first experiment deals with the prompt fission neutron multiplicity in the thermal neutron induced fission of U-235(n,f). The second, on the fission fragment properties in the thermal fission of U-234(n,f). The prompt fission neutron multiplicity has been measured at the JRC-IRMM using two liquid scintillators in coincidence with an ionization chamber. The first experimental campaign focused on U-235(nth,f) whereas a second experimental campaign is foreseen later for the same reaction at 5.5 MeV. The goal is to investigate how the so-called saw-tooth shape changes as a function of fragment mass and excitation energy. Some harsh experimental conditions were experienced due to the large radiation background. The solution to this will be discussed along with preliminary results. In addition, the analysis of thermal neutron induced fission of U-234(n,f) will be discussed. Currently analysis of data is ongoing, originally taken at the ILL reactor. The experiment is of particular interest since no measurement exist of the mass and energy distributions for this system at thermal energies. One main problem encountered during analysis was the huge background of U-235(nth, f). Despite the negligible isotopic traces in the sample, the cross section difference is enormous. Solution to this parasitic background will be highlighted.
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| 32. |
- Al-Adili, Ali, et al.
(författare)
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Prompt fission neutron yields in thermal fission of U-235 and spontaneous fission of Cf-252
- 2020
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Ingår i: Physical Review C. - : American Physical Society (APS). - 2469-9985 .- 2469-9993. ; 102:6
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Tidskriftsartikel (refereegranskat)abstract
- Background: The sharing of excitation energy between the fission fragments is one of the key issues in studying nuclear fission. One way to address this is by studying prompt-fission neutron multiplicities as a function of other fission observables such as the mass, (nu) over bar (A). These are vital benchmark data for both fission and nuclear deexcitation models, putting constrains on the fragment excitation energy and hence on the competing prompt neutron/gamma-ray emission. Despite numerous detailed studies, recent measurements done at JRC-Geel with the SCINTIA array in the epithermal region show surprisingly strong discrepancies to earlier thermal fission data and the Wahl systematics. Purpose: The purpose was to perform measurements of the prompt-fission neutron multiplicity, as a function of fragment mass and total kinetic energy (TKE), in U-235(n(th), f) and Cf-252(sf), to verify and extend the SCINTIA results. Another goal was to validate the analysis methods, and prepare for planned investigations at excitation energies up to 5.5 MeV. Methods: The experiments were conducted at the former 7 MV Van de Graaff facility in JRC-Geel, using a Twin Frisch-Grid Ionization Chamber and two liquid scintillation detectors. A neutron beam with an average energy of 0.5 MeV was produced via the Li-7(p,n) reaction. The neutrons were thermalized by a 12 cm thick block of paraffin. Digital data acquisition systems were utilized. Comprehensive simulations were performed to verify the methodology and to investigate the role of the mass and energy resolution on measured (nu) over bar (A) and (nu) over bar (TKE) values. The simulation results also revealed that the partial derivative(nu) over bar/partial derivative A and partial derivative(TKE) over bar/partial derivative(nu) over bar are affected by the mass and energy resolution. However, the effect is small for the estimated resolutions of this work. Detailed Fluka simulations were performed to calculate the fraction of thermal neutron-induced fission, which was estimated to be about 98%. Results: The experimental results on (nu) over bar (A) are in good agreement with earlier data for Cf-252(sf). For U-235(n(th), f), the (nu) over bar (A) data is very similar to the data obtained with SCINTIA, and therefore we verify these disclosed discrepancies to earlier thermal data and to the Wahl evaluation. The experimental results on (nu) over bar (TKE) are also in agreement with the data at epithermal energies. For Cf-252(sf) a slope value of partial derivative(TKE) over bar/partial derivative(nu) over bar = (-12.9 f 0.2) MeV/n was obtained. For U-235(n(th), f) the value is (-12.0 +/- 0.1) MeV/n. Finally, the neutron spectrum in the center-of-mass system was derived and plotted as a function of fragment mass. Conclusions: This work clearly proves the lack of accurate correlation between fission fragment and neutron data even in the best-studied reactions. The new results highlight the need of a new evaluation of the prompt-fission multiplicity for U-225(n(th), f).
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| 33. |
- ALGOTSSON, A, et al.
(författare)
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Autonomic dysfunction in Alzheimer's disease
- 1995
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Ingår i: Acta neurologica Scandinavica. - : Hindawi Limited. - 0001-6314 .- 1600-0404. ; 91:1, s. 14-18
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Tidskriftsartikel (refereegranskat)
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| 34. |
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| 35. |
- Danielsson, A, et al.
(författare)
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Pallidal Deep Brain Stimulation in DYT6 Dystonia: Clinical Outcome and Predictive Factors for Motor Improvement
- 2019
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Ingår i: Journal of clinical medicine. - : MDPI AG. - 2077-0383. ; 8:12
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Tidskriftsartikel (refereegranskat)abstract
- Pallidal deep brain stimulation is an established treatment in dystonia. Available data on the effect in DYT-THAP1 dystonia (also known as DYT6 dystonia) are scarce and long-term follow-up studies are lacking. In this retrospective, multicenter follow-up case series of medical records of such patients, the clinical outcome of pallidal deep brain stimulation in DYT-THAP1 dystonia, was evaluated. The Burke Fahn Marsden Dystonia Rating Scale served as an outcome measure. Nine females and 5 males were enrolled, with a median follow-up of 4 years and 10 months after implant. All benefited from surgery: dystonia severity was reduced by a median of 58% (IQR 31-62, p = 0.001) at last follow-up, as assessed by the Burke Fahn Marsden movement subscale. In the majority of individuals, there was no improvement of speech or swallowing, and overall, the effect was greater in the trunk and limbs as compared to the cranio-cervical and orolaryngeal regions. No correlation was found between disease duration before surgery, age at surgery, or preoperative disease burden and the outcome of deep brain stimulation. Device- and therapy-related side-effects were few. Accordingly, pallidal deep brain stimulation should be considered in clinically impairing and pharmaco-resistant DYT-THAP1 dystonia. The method is safe and effective, both short- and long-term.
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| 40. |
- Gao, Zhihao, et al.
(författare)
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Benchmark of a multi-physics Monte Carlo simulation of an ionguide for neutron-induced fission products
- 2022
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Ingår i: European Physical Journal. - : Springer Nature. - 1286-0042 .- 1286-0050. ; 58:2
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Tidskriftsartikel (refereegranskat)abstract
- To enhance the production of medium-heavy,neutron-rich nuclei, and to facilitate measurements of independentyields of neutron-induced fission, a proton-toneutronconverter and a dedicated ion guide for neutroninducedfission have been developed for the IGISOL facilityat the University of Jyväskylä. The ion guide holds thefissionable targets, and the fission products emerging fromthe targets are collected in helium gas and transported to thedownstream experimental stations.Acomputer model, basedon a combination of MCNPX for modeling the neutron production,the fission code GEF, and GEANT4 for the transportof the fission products, was developed. The model willbe used to improve the setup with respect to the productionand collection of fission products. In this paper we benchmarkthe model by comparing simulations to a measurementin which fission products were implanted in foils located atdifferent positions in the ion guide. In addition, the productsfrom neutron activation in the titanium foil and the uraniumtargets are studied. The result suggests that the neutron fluxat the high-energy part of the neutron spectrum is overestimatedby approximately 40%.However, the transportation offission products in the uranium targets agrees with the experimentwithin 10%. Furthermore, the simulated transportationof fission products in the helium gas achieves almost perfectagreement with the measurement. Hence, we conclude thatthe model, after correction for the neutron flux, is well suitedfor optimization studies of future ion guide designs.
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| 41. |
- Gao, Zhihao, et al.
(författare)
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Fission studies at IGISOL/JYFLTRAP : Simulations of the ion guide for neutron-induced fission and comparison with experimental data
- 2020
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Ingår i: ND 2019. - : EDP Sciences. - 9782759891061
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Konferensbidrag (refereegranskat)abstract
- For the production of exotic nuclei at the IGISOL facility, an ion guide for neutron-induced fission has been developed and tested in experiments. Fission fragments are produced inside the ion guide and collected using a helium buffer gas. Meanwhile, a GEANT4 model has been developed to simulate the transportation and stopping of the charged fission products. In a recent measurement of neutron-induced fission yields, implantation foils were located at different positions in the ion guide. The gamma spectra from these foils and the fission targets are compared to the results from the GEANT4 simulation.In order to allow fission yield measurements in the low yield regions, towards the tails and in the symmetric part of the mass distribution, the stopping and extraction efficiency of the ion guide has to be significantly improved. This objective can be achieved by increasing the size while introducing electric field guidance using a combination of static electrodes and an RF-carpet. To this end, the GEANT4 model is used to optimise the design of such an ion guide.
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| 42. |
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| 43. |
- Gorelov, D., et al.
(författare)
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Isomeric Yield Ratios of Fission Products Measured with the Jyfltrap
- 2014
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Ingår i: Acta Physica Polonica B. - 0587-4254 .- 1509-5770. ; 45:2, s. 211-216
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Tidskriftsartikel (refereegranskat)abstract
- Experimental methods to determine isomeric yield ratios usually apply gamma-spectroscopic techniques. In such methods, ground and isomeric states are distinguished by their decays. In the present work, several isomeric yield ratios of fission products have been measured by utilizing capabilities of the double Penning-trap mass spectrometer JYFLTRAP, where isomeric and ground state were separated by their masses. To verify the new experimental technique, the results were compared to those from gamma-spectroscopy measurements.
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| 44. |
- Gorelov, D., et al.
(författare)
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Measuring independent yields of fission products using a penning trap
- 2015
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Ingår i: Bulletin of the Russian Academy of Sciences: Physics. - 1062-8738. ; 79:7, s. 869-871
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Tidskriftsartikel (refereegranskat)abstract
- A new method for determining independent fission products is used in an experiment at the Accelerator Laboratory of the University of Jyväskylä. The method combines the chemical universality of the ion guide technique and the unique properties of the Penning trap. A beam of charged particles is formed by stopping fission products in gaseous helium. The Penning trap is employed as a highly accurate filter to identify particles by their mass. The yields of fission products are determined by the ion count downstream of the trap. The setup’s mass resolving power is on the order of 105 with a radio frequency excitation time of 400 ms. Such high mass resolution occasionally allows us not only to separate nuclides but to separate the isomeric and ground states of nuclei as well. Independent yields of fission products are measured in the fission reaction of the 232Th isotope by protons with an energy of 25 MeV. A short description of the method ae nd soexperimental data are supplememnted by the results fro theoretical calculations.
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| 45. |
- Lindau, Robert, et al.
(författare)
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Decidual stromal cells support tolerance at the human foetal-maternal interface by inducing regulatory M2 macrophages and regulatory T-cells
- 2021
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Ingår i: Journal of Reproductive Immunology. - : Elsevier Ireland Ltd. - 0165-0378 .- 1872-7603. ; 146
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Tidskriftsartikel (refereegranskat)abstract
- During pregnancy, the semi-allogeneic nature of the foetus requires maternal immune adaption and acquisition of tolerance at the foetal-maternal interface. Macrophages with regulatory properties and regulatory T (Treg) cells are central in promoting foetal tolerance and are enriched in the decidua (the uterine endometrium during pregnancy). Although tissue-resident decidual stromal cells (DSC) have been implicated in regulatory functions, it is not known if they are able to induce the regulatory phenotype of macrophages and T-cells. In this study we report that maternally derived DSC are able to induce homeostatic M2 macrophages and Treg cells. CD14+ monocytes and CD4+ T-cells from healthy non-pregnant women were cultured in the presence or absence of conditioned medium (CM) from DSC isolated from 1st trimester and term placentas. DSC-CM alone was able to promote the survival of macrophages and to induce a regulatory CD14brightCD163+CD209+CD86dim phenotype, typical for decidual macrophages and similar to that induced by M-CSF. Interestingly, DSC-CM was also able to overrule the pro-inflammatory effects of GM-CSF by upregulating CD14, CD163 and CD209. Protein-profiling showed that M-CSF was secreted by DSC, and blocking of M-CSF partially reversed the M2 phenotype and reduced viability. DSC-CM also expanded CD25brightFoxp3+ Treg cells, an expansion that was abolished by a SMAD3-inhibitor, indicating the contribution of TGF-beta signaling. In conclusion, our findings collectively emphasize the role of tissue-resident stromal cells in shaping the tolerogenic environment at the foetal-maternal interface.
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| 46. |
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| 47. |
- Magalhaes, I, et al.
(författare)
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MAIT Cells in Health and Disease
- 2020
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Ingår i: Methods in molecular biology (Clifton, N.J.). - New York, NY : Springer US. - 1940-6029. ; 2098, s. 3-21
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Tidskriftsartikel (refereegranskat)
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| 48. |
- Mattera, Andrea, 1985-, et al.
(författare)
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A neutron source for IGISOL-JYFLTRAP : Design and characterisation
- 2017
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Ingår i: European Physical Journal A. - : Springer Science and Business Media LLC. - 1434-6001 .- 1434-601X. ; 53:173
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Tidskriftsartikel (refereegranskat)abstract
- A white neutron source based on the Be(p,nx) reaction for fission studies at the IGISOLJYFLTRAP facility has been designed and tested. 30 MeV protons impinge on a 5mm thick water-cooled beryllium disc. The source was designed to produce at least 1012 fast neutrons/s on a secondary fission target, in order to reach competitive production rates of fission products far from the valley of stability.The Monte Carlo codes MCNPX and FLUKA were used in the design phase to simulate the neutron energy spectra. Two experiments to characterise the neutron field were performed: the first was carried out at The Svedberg Laboratory in Uppsala (SE), using an Extended-Range Bonner Sphere Spectrometer and a liquid scintillator which used the time-of-flight (TOF) method to determine the energy of the neutrons; the second employed Thin-Film Breakdown Counters for the measurement of the TOF, and activation foils, at the IGISOL facility in Jyväskylä (FI). Design considerations and the results of the two characterisation measurements are presented, providing benchmarks for the simulations.
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| 49. |
- Nagy, Sz, et al.
(författare)
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Precision mass measurements of 40Ca17+ and 40Ca19+ ions in a Penning trap
- 2006
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Ingår i: European Physical Journal D. - : Springer Science and Business Media LLC. - 1434-6060 .- 1434-6079. ; 39:1, s. 1-4
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Tidskriftsartikel (refereegranskat)abstract
- High-precision mass measurements on lithium-like and hydrogen-like 40Ca-ions are reported. The obtained mass of the hydrogen-like and lithium-like ion is 39.952181819(29) u and 39.953272223(24) u, respectively. The corresponding mass of the 40Ca atom is 39.962590858(22) u. This new value has a precision ten times higher than the literature value.
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| 50. |
- Neudecker, Denise, et al.
(författare)
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Templates of expected measurement uncertainties
- 2023
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Ingår i: EPJ NUCLEAR SCIENCES & TECHNOLOGIES. - : EDP Sciences. - 2491-9292. ; 9
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Tidskriftsartikel (refereegranskat)abstract
- The covariance committee of CSEWG (Cross Section Evaluation Working Group) established templates of expected measurement uncertainties for neutron-induced total, (n,gamma), neutron-induced charged-particle, and (n,xn) reaction cross sections as well as prompt fission neutron spectra, average prompt and total fission neutron multiplicities, and fission yields. Templates provide a list of what uncertainty sources are expected for each measurement type and observable, and suggest typical ranges of these uncertainties and correlations based on a survey of experimental data, associated literature, and feedback from experimenters. Information needed to faithfully include the experimental data in the nuclear-data evaluation process is also provided. These templates could assist (a) experimenters and EXFOR compilers in delivering more complete uncertainties and measurement information relevant for evaluations of new experimental data, and (b) evaluators in achieving a more comprehensive uncertainty quantification for evaluation purposes. This effort might ultimately lead to more realistic evaluated covariances for nuclear-data applications. In this topical issue, we cover the templates coming out of this CSEWG effort-typically, one observable per paper. This paper here prefaces this topical issue by introducing the concept and mathematical framework of templates, discussing potential use cases, and giving an example of how they can be applied (estimating missing experimental uncertainties of 235U(n,f) average prompt fission neutron multiplicities), and their impact on nuclear-data evaluations.
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