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Tidskriftsartikel (refereegranskat)
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- Young, WJ, et al.
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Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease
- 2023
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 14:1, s. 1411-
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Tidskriftsartikel (refereegranskat)abstract
- The 3-dimensional spatial and 2-dimensional frontal QRS-T angles are measures derived from the vectorcardiogram. They are independent risk predictors for arrhythmia, but the underlying biology is unknown. Using multi-ancestry genome-wide association studies we identify 61 (58 previously unreported) loci for the spatial QRS-T angle (N = 118,780) and 11 for the frontal QRS-T angle (N = 159,715). Seven out of the 61 spatial QRS-T angle loci have not been reported for other electrocardiographic measures. Enrichments are observed in pathways related to cardiac and vascular development, muscle contraction, and hypertrophy. Pairwise genome-wide association studies with classical ECG traits identify shared genetic influences with PR interval and QRS duration. Phenome-wide scanning indicate associations with atrial fibrillation, atrioventricular block and arterial embolism and genetically determined QRS-T angle measures are associated with fascicular and bundle branch block (and also atrioventricular block for the frontal QRS-T angle). We identify potential biology involved in the QRS-T angle and their genetic relationships with cardiovascular traits and diseases, may inform future research and risk prediction.
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- Ahmadi, H., et al.
(författare)
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Experimental Research on Variation of Pore Water Pressure in Constant Rate of Strain Consolidation Test
- 2014
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Ingår i: Acta Geotechnica Slovenica. - 1854-0171. ; 11:2, s. 46-57
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Tidskriftsartikel (refereegranskat)abstract
- Constant rate of strain (CRS) consolidation is a rapid test method which is used for determination of compressibility of clayey soils. In a CRS test, the appropriate strain rate is selected based on pore water pressure ratio, i.e. the ratio of pore pressure to total stress. In the present study, to investigate the effect of strain rate on variation of pore water pressure ratio, four different clay samples of different plasticity were tested by CRS apparatus. The results of the experiments showed that the trend of variation of pore water pressure is dependent on the drained water flow regime which may be either Darcy or non-Darcy. The results also indicated that the plasticity of clay does not have considerable effect on variation of pore water pressure.
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- Bahadori, A, et al.
(författare)
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Non H.pylori Helicobacter Identified as H.heilmannii in Gastric Biopsy samples in humans with gasteric disorders by PCR and Microscopic Methods in IRAN (First Report)
- 2014
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Ingår i: Europen Journal Of Zoological Research. - 2278-7356. ; 3:1, s. 92-96
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The Discovery of Helicobacter pylori in 1982 increased interest in the range of other spiral bacteria that had been seen in Stomach.The power of technologies such as the polymerase chain reaction (PCR) with genus specific primers revealed that many of these bacteria belong to the genus Helicobacter. These non-pylori helicobacters are increasingly being found in human clinical specimens. Non-pylori Helicobacters are Gram-negative, motile, long, tightly coiled, Spiral bacteria ,with three to eight coils, that cause of some gastric problems like gastritis, peptic ulceration and Mcosa-Associated Lymphoid Tissue (MALT) lynphoma in animals and humans. Samples taken during endoscopy were analyzed by rapid urease test, PCR and light microscope(Giemsa and Gram staining). In this study 810 biopsy samples from 270 patients with gastric disorders were collected. Presence of Helicobacters confirmed by a positive urease test and Helicobacter genus specific PCR method utilized. DNA was prepared from biopsies using the Qiamp tissue kit (QIAGEN Inc., Valencia, Calif.) and frozen at -20°C (like gastric samples/biopsies). DNA samples were amplified with 16SrRNA gene primers against Helicobacter species. In gastric biopsy specimen's non-pylori helicobacter spp., have been observed. At the end of the study we found that 71% of urease tests, 0.37% of light microscopic studies (we observed some spiral gram negative bacteria with 2-7 coils) and 0.74% of PCR tests were positive. In analysis with PCR route 2 person (both of them were Male) were infected with H.heilmannii-like organisms( one of them kept a dog for 5 years as a pet).16S rRNA gene amplification was performed on 270 DNA samples and results were positive for H.heilmannii in two cases (275-bp), but negative for H.bizzozeronnii,H.felis and H. Salmonis
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- Soroush, A, et al.
(författare)
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Effects of a 6-Month Walking Study on Blood Pressure and Cardiorespiratory Fitness in U.S. and Swedish Adults: ASUKI Step Study
- 2013
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Ingår i: Asian journal of Sports Medicine. - : Briefland. - 2008-000X .- 2008-7209. ; 4:2, s. 114-124
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE:The aim of this study was to assess the effects of a six-month pedometer-based workplace intervention on changes in resting blood pressure (BP) and cardiorespiratory fitness (CRF).METHODS:A subsample of ASUKI Step participants (n= 355) were randomly selected to have changes in their BP and CRF monitored during the intervention. Pedometers were used to monitor steps taken with a goal of walking more than 10,000 steps/day. Systolic and diastolic BP were taken using an Omron automated BP cuff. Estimated VO2 max was obtained using the Åstrand-Rhyming cycle ergometer test. A multi-level growth modeling approach, and a mixed model ANOVA were used to predict changes in systolic and diastolic BP, and estimated VO2 max over time by steps, age, gender, and university site.RESULTS:Steps/day averaged 12,256 (SD = 3,180) during month 1 and steadily decreased to month 6. There were significant linear and quadratic trends in systolic and diastolic BP over time. Age was positively related to initial starting values for systolic and diastolic BP, and approached significance for systolic BP changes over time. Steps/day approached significance for linear changes in systolic BP. There was a significant difference between ASU and KI participants' estimated VO2 max. There was a significant change over time in the estimated VO2 max. The number of steps taken was significantly related to changes in estimated VO2 max over time.CONCLUSIONS:The results of the present study indicate that healthy individuals who took part in a pedometer intervention improved several cardiovascular disease risk factors.
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