| 1. |
- Glimelius, Bengt, et al.
(författare)
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U-CAN : a prospective longitudinal collection of biomaterials and clinical information from adult cancer patients in Sweden.
- 2018
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Ingår i: Acta Oncologica. - : Taylor & Francis. - 0284-186X .- 1651-226X. ; 57:2, s. 187-194
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Tidskriftsartikel (refereegranskat)abstract
- Background: Progress in cancer biomarker discovery is dependent on access to high-quality biological materials and high-resolution clinical data from the same cases. To overcome current limitations, a systematic prospective longitudinal sampling of multidisciplinary clinical data, blood and tissue from cancer patients was therefore initiated in 2010 by Uppsala and Umeå Universities and involving their corresponding University Hospitals, which are referral centers for one third of the Swedish population.Material and Methods: Patients with cancer of selected types who are treated at one of the participating hospitals are eligible for inclusion. The healthcare-integrated sampling scheme encompasses clinical data, questionnaires, blood, fresh frozen and formalin-fixed paraffin-embedded tissue specimens, diagnostic slides and radiology bioimaging data.Results: In this ongoing effort, 12,265 patients with brain tumors, breast cancers, colorectal cancers, gynecological cancers, hematological malignancies, lung cancers, neuroendocrine tumors or prostate cancers have been included until the end of 2016. From the 6914 patients included during the first five years, 98% were sampled for blood at diagnosis, 83% had paraffin-embedded and 58% had fresh frozen tissues collected. For Uppsala County, 55% of all cancer patients were included in the cohort.Conclusions: Close collaboration between participating hospitals and universities enabled prospective, longitudinal biobanking of blood and tissues and collection of multidisciplinary clinical data from cancer patients in the U-CAN cohort. Here, we summarize the first five years of operations, present U-CAN as a highly valuable cohort that will contribute to enhanced cancer research and describe the procedures to access samples and data.
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| 2. |
- Boström, Cecilia, et al.
(författare)
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Experimental results of rectification and filtration from an offshore wave energy system
- 2009
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Ingår i: Renewable energy. - : Elsevier BV. - 0960-1481 .- 1879-0682. ; 34:5, s. 1381-1387
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Tidskriftsartikel (refereegranskat)abstract
- The present paper presents results from a wave energy conversion that is based on a direct drive linear generator. The linear generator is placed on the seabed and connected to a buoy via a rope. Thereby, the natural wave motion is transferred to the translator by the buoy motion. When using direct drive generators, voltage and current output will have varying frequency and varying amplitude and the power must be converted before a grid connection. The electrical system is therefore an important part to study in the complete conversion system from wave energy to grid connected power. This paper will bring up the first steps in the conversion: rectification and filtration of the power. Both simulation studies and offshore experiments have been made. The results indicate that this kind of system works in a satisfactory way and a smooth DC power can be achieved with one linear generator.
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| 3. |
- Boström, Cecilia, et al.
(författare)
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Study of aWave Energy Converter Connected to a Nonlinear Load
- 2009
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Ingår i: IEEE Journal of Oceanic Engineering. - 0364-9059 .- 1558-1691. ; 34:2, s. 123-127
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents experimental results from a wave energy converter (WEC) that is based on a linear generator connected to a rectifier and filter components. The converter-filter system is installed onshore, while the linear wave generator operates offshore a few kilometers from the Swedish west coast. The power from the generator has been rectified with a diode bridge and then filtered using a capacitive filter. Performance of the whole conversion system was studied using resistive loads connected across the filter. The aim was to investigate the operational characteristics of the generator while supplying a nonlinear load. By changing the value of the resistive component of the load, the speed of the translator can be changed and so also the damping of the generator. The power absorbed by the generator was studied at different sea states as well. The observations presented in this paper could be beneficial for the design of efficient wave energy conversion systems.
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| 7. |
- Håkansson, H., et al.
(författare)
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In vivo and in vitro toxicity of fractionated fish lipids, with particular regard to their content of chlorinated organic compounds
- 1991
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Ingår i: Pharmacology and Toxicology. - : Wiley. - 0901-9928 .- 1600-0773. ; 69:6, s. 459-471
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Tidskriftsartikel (refereegranskat)abstract
- Six different lipid matrices (the intact lipid (IL), four lipid fractions with different polarity, and the free fatty acids (FFAs) obtained by hydrolysis of the triacylglycerol (TAG) containing fraction) were obtained from salmon (Salmo salar) and eel (Anguilla anguilla), each collected at a contaminated and a comparatively uncontaminated catch site along the coast of Scandinavia. The lipid matrices were studied in toxicological test systems representing various biological functions of different organ systems from several species and trophic levels. The results were evaluated with particular respect to the concentrations of extractable organically bound chlorine (EOCl) in the matrices tested. In some test systems, the specimens with a higher EOCl concentration appeared to be more toxic. For example, the TAG containing fraction (F2) from Idefjord eel, having a higher EOCl content than F2 from Oslofjord eel, reduced the number and hatchability of eggs laid by zebrafish. Both IL and F2 of Idefjord eel increased mortality and reduced the oxygen/nitrogen-ratio in blue mussels. Non-polar compounds (F1) from Bothnian Sea salmon induced 7-ethoxyresurofin O-deethylase (EROD) activity in rainbow trout hepatocytes, whereas F1 from Senja salmon did not. F1 from Bothnian Sea salmon also reduced the number of T-cells in foetal mouse thymus anlagen in vitro compared with the cell number in anlagen exposed to F1 from Senja salmon. A positive correlation between EOCl concentration and test response was found for EROD activity in rainbow trout hepatocytes and for ATP-leakage in Erlich ascites tumour cells when testing the phospolipid containing fraction (F4). However, in most test systems the fish oils, irrespective of EOCl content, were of low toxicity, and the observed effects need to be verified in future studies.
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| 8. |
- Leijon, Mats, et al.
(författare)
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Wave Energy from the North Sea : Experiences from the Lysekil Research Site
- 2008
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Ingår i: Surveys in geophysics. - : Springer Science and Business Media LLC. - 0169-3298 .- 1573-0956. ; 29:3, s. 221-240
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Forskningsöversikt (refereegranskat)abstract
- This paper provides a status update on the development of the Swedish wave energy research area located close to Lysekil on the Swedish West coast. The Lysekil project is run by the Centre for Renewable Electric Energy Conversion at Uppsala University. The project was started in 2004 and currently has permission to run until the end of 2013. During this time period 10 grid-connected wave energy converters, 30 buoys for studies on environmental impact, and a surveillance tower for monitoring the interaction between waves and converters will be installed and studied. To date the research area holds one complete wave energy converter connected to a measuring station on shore via a sea cable, a Wave Rider™ buoy for wave measurements, 25 buoys for studies on environmental impact, and a surveillance tower. The wave energy converter is based on a linear synchronous generator which is placed on the sea bed and driven by a heaving point absorber at the ocean surface. The converter is directly driven, i.e. it has no gearbox or other mechanical or hydraulic conversion system. This results in a simple and robust mechanical system, but also in a somewhat more complicated electrical system.
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| 9. |
- Sjögren, Erik, et al.
(författare)
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Assessment of Free Drug Concentration in Cyclodextrin Formulations Is Essential to Determine Drug Potency in Functional In Vitro Assays
- 2016
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Ingår i: Journal of Pharmaceutical Sciences. - : Elsevier BV. - 0022-3549 .- 1520-6017. ; 105:9, s. 2913-2920
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Tidskriftsartikel (refereegranskat)abstract
- Cyclodextrins (CD) have the ability to form inclusion complexes with drugs and can be used as excipients to enhance solubility of poorly soluble drugs. To make accurate estimations of the potency of the drug, knowledge of the free drug concentration is important. The aim of this study was to evaluate the applicability of calculated free drug concentrations toward response measurements in a transient receptor potential vanilloid receptor-1 cell-based in vitro assay. This included accounting for potential competitive CD binding of 2 transient receptor potential vanilloid receptor-1 active entities: 1 antagonist, and 1 agonist (capsaicin). Solubility of the CD-drug complexes was measured, and the ligand to substrate affinity in CD formulations was determined according to the phase-solubility technique. The total concentration of antagonist, agonist, CD, and the binding constants between ligands and CD were used to calculate the free concentration of CD ligands. For capsaicin and 2 of the 3 investigated model drugs, the calculated free drug concentration was consistent with the experimental in vitro data while it was overestimated for one of the compounds. In conclusion, the suggested approach can be used to calculate free drug concentration and competitive binding in CD formulations for the application of cell-based drug functionality assays. (C) 2016 American Pharmacists Association (R). Published by Elsevier Inc. All rights reserved.
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| 13. |
- Stålberg, Magnus, et al.
(författare)
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Influence of Generator Damping on Peak Power and Variance of Power for a Direct Drive Wave Energy Converter
- 2008
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Ingår i: Journal of Offshore Mechanics and Arctic Engineering-Transactions of The Asme. - : ASME International. - 0892-7219 .- 1528-896X. ; 130:3, s. 031003-
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Tidskriftsartikel (refereegranskat)abstract
- The first offshore prototype of a wave energy converter system has been launched off the Swedish west coast. The concept is based on a point absorber directly coupled to a linear generator located on the ocean floor. The wave energy converter is part of a research project that will study the electric system of ten units forming a small farm of wave power plants as they are linked and connected to an electric grid. A full scale farm will consist of a large number of interconnected units. The chosen direct drive system reduces the mechanical complexity of the converter but has repercussions on the electric system. The output from the generator will vary with the speed of the point absorber, leading to large fluctuations of power on the second scale. This has implications on both the individual generator and on the system as a whole. The hydrodynamic behavior of the point absorber depends, to a large extent, on the damping of the generator. The damping, in turn, can be remotely controlled by changing the load resistance. It has previously been shown that this has a large influence on the power absorbed by the wave energy converter. This paper investigates the peak power, the translator speed, and the variance of the power at different sea states and for different levels of damping. The peak power has an impact on the design of the generator and the required ability, for a single unit, to handle electric overloads. The momentum of the translator is directly proportional to its speed. The speed is thus important for the design of the end stop. The variance of the power of one unit will have an impact on the farm system behavior. The study is based on two and a half months of experimental measurements on the prototype wave energy converter and a wave measurement buoy. The aim is to analyze whether load control strategies may influence the dimensioning criteria for the electric system and the generator. The results are compared to previously investigated relationships between the absorbed mean power and the load resistance as a function of sea state. In the study, it was found that the maximum power is approximately proportional to the average power, while the maximum translator speed and standard deviation decrease as the damping factor is increased.
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| 14. |
- Stålberg, Magnus, et al.
(författare)
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Influence of Generator Damping on Peak Power and Variance of Power for a Direct Drive Wave Energy Coverter
- 2007
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Ingår i: Proceedings of the 26th International Conference on Offshore Mechanics and Arctic Engineering, Vol 5. - 9780791842713 ; , s. 501-504
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Konferensbidrag (refereegranskat)abstract
- The first full-scale offshore prototype of a novel wave energy converter system has been launched off the Swedish west coast. The concept is based on a point absorber directly coupled to a linear generator located on the ocean floor. The wave energy converter is part of a research project that will study the electrical system of 10 units forming a small farm of wave power plants as they are linked and connected to an electric grid. A full scale farm will consist of a large number of interconnected units. The chosen direct drive system reduces the mechanical complexity of the converter but has repercussions on the electrical system. The output from the generator will vary with the speed of the point absorber, leading to large fluctuations of power on the second scale. This has implications on both the individual generator and on the system as a whole. The hydrodynamic behavior of the point absorber depends, to a large extent, on the damping of the generator. The damping, in turn, can be controlled remotely by changing the load resistance. It has previously been shown that this has a large influence on the power absorbed by the wave energy converter. This paper investigates the peak power, the translator speed and the variance of the power at different sea states and for different levels of damping. The peak power has an impact on the design of the generator and the required ability, for a single unit, to handle electrical overloads. The speed of the translator is directly proportional to its momentum. It is thus important for the design of the end stop. The variance of the power of one unit will have an impact on the farm system behavior. The study is based on two and a half months of experimental measurements on the prototype wave energy converter and a wave measurement buoy. The aim is to analyze whether load control strategies may influence the dimensioning criteria for the electrical system and the generator. The results are compared with previously investigated relationships between absorbed mean power and load resistance as a function of sea state. In the study it was found that the maximum power is approximately proportional to the average power while maximum translator speed and standard deviation decrease as the damping factor is increased.
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| 15. |
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| 16. |
- Waters, Rafael, et al.
(författare)
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Experimental results from sea trials of an offshore wave energy system
- 2007
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Ingår i: Applied Physics Letters. - : AIP Publishing. - 0003-6951 .- 1077-3118. ; 90:3, s. 034105-
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Tidskriftsartikel (refereegranskat)abstract
- A full-scale prototype of a wave power plant has been installed off the Swedish west coast and the overall wave energy converter concept has been verified. Initial results have been collected and significant insights discovered. Energy absorption dependency on load as well as output voltage and power is demonstrated. It is shown that great overload capability of the directly driven linear generator is critical, and indicated that, for resistive loads, optimal load does not vary with wave climate. Future grid supplying energy production would necessitate parks of wave power plants in order to reduce power fluctuations.
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