| 1. |
- Aurumskjöld, Marie-Louise, et al.
(författare)
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Evaluation of an iterative model-based reconstruction of pediatric abdominal CT with regard to image quality and radiation dose
- 2018
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Ingår i: Acta Radiologica. - : SAGE Publications. - 1600-0455 .- 0284-1851. ; 59:6, s. 740-747
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundIn pediatric patients, computed tomography (CT) is important in the medical chain of diagnosing and monitoring various diseases. Because children are more radiosensitive than adults, they require minimal radiation exposure. One way to achieve this goal is to implement new technical solutions, like iterative reconstruction.PurposeTo evaluate the potential of a new, iterative, model-based method for reconstructing (IMR) pediatric abdominal CT at a low radiation dose and determine whether it maintains or improves image quality, compared to the current reconstruction method.Material and MethodsForty pediatric patients underwent abdominal CT. Twenty patients were examined with the standard dose settings and 20 patients were examined with a 32% lower radiation dose. Images from the standard examination were reconstructed with a hybrid iterative reconstruction method (iDose4), and images from the low-dose examinations were reconstructed with both iDose4 and IMR. Image quality was evaluated subjectively by three observers, according to modified EU image quality criteria, and evaluated objectively based on the noise observed in liver images.ResultsVisual grading characteristics analyses showed no difference in image quality between the standard dose examination reconstructed with iDose4 and the low dose examination reconstructed with IMR. IMR showed lower image noise in the liver compared to iDose4 images. Inter- and intra-observer variance was low: the intraclass coefficient was 0.66 (95% confidence interval = 0.60–0.71) for the three observers.ConclusionIMR provided image quality equivalent or superior to the standard iDose4 method for evaluating pediatric abdominal CT, even with a 32% dose reduction.
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| 3. |
- Königsson, Fredrik, 1983-, et al.
(författare)
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Characterization and Potential of Dual FuelCombustion in a Modern Diesel Engine
- 2011
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Ingår i: SAE Technical Paper 2011-01-2223. - 400 Commonwealth Drive, Warrendale, PA, United States : SAE International.
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Konferensbidrag (refereegranskat)abstract
- Diesel Dual Fuel, DDF, is a concept which promises the possibility to utilize CNG/biogas in a compression ignition engine maintaining a high compression ratio, made possible by the high knock resistance of methane, and the resulting benefits in thermal efficiency associated with Diesel combustion.A series of tests has been carried out on a single cylinder lab engine, equipped with a modern common rail injection system supplying the diesel fuel and two gas injectors, placed in the intake runners. One feature of port injected Dual Fuel is that full diesel functionality is maintained, which is of great importance when bringing the dual fuel technology to market. The objective of the study was to characterize and investigate the potential for dual fuel combustion utilizing all degrees of freedom available in a modern diesel engine.Increased diesel pilot proved efficient at reducing NOx emissions at low λ. Advanced combustion phasing has the potential to extend the lean limit for operation. Stoichiometric operation using high levels of EGR is identified as a promising field in conjunction with raised inlet temperature.
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| 4. |
- Königsson, Fredrik, 1983-, et al.
(författare)
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Combustion Modes in a Diesel-CNG Dual Fuel Engine
- 2011
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Ingår i: SAE Technical Paper 2011-01-1962, 2011. - 400 Commonwealth Drive, Warrendale, PA, United States : Society of Automotive Engineers of Japan, Inc. ; , s. 2387-2398
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Konferensbidrag (refereegranskat)abstract
- Diesel Dual Fuel, DDF, is a concept where a combination of methane and diesel is used in a compression ignited engine, maintaining the high compression ratio of a diesel engine with the resulting benefits in thermal efficiency.One benefit of having two fuels on board the vehicle is the additional degree of freedom provided by the ratio between the fuels. This additional degree of freedom enables control of combustion phasing for combustion modes such as Homogenous Charge Compression Ignition, HCCI, and Partly Premixed Compression Ignition, PPCI. These unconventional combustion modes have great potential to limit emissions at light load while maintaining the low pumping losses of the base diesel engine.A series of tests has been carried out on a single cylinder lab engine, equipped with a modern common rail injection system supplying the diesel fuel and two gas injectors, placed in the intake runners. Four load points are investigated and three different types of combustion are evaluated.The study confirmed the desirable emission characteristics of HCCI and PPCI combustion and demonstrated the potential to control the combustion phasing by utilizing all degrees of freedom provided by a common rail injection system and two fuels.
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| 5. |
- Königsson, Fredrik, 1983-, et al.
(författare)
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Controlling the Injector Tip Temperature in a DieselDual Fuel Engine
- 2012
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Ingår i: SAE Technical Paper Series. - 400 Commonwealth Drive, Warrendale, PA, United States : SAE International. - 0148-7191.
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Konferensbidrag (refereegranskat)abstract
- Diesel Dual Fuel, DDF, is a concept where a combination of methane and diesel is used in a compression ignited engine, maintaining the high compression ratio of a diesel engine with the resulting benefits in thermal efficiency. Attention has recently been drawn to the fact that the tip of the diesel injector may reach intolerable temperatures. The high injector tip temperatures in the DDF engine are caused by the reduction in diesel flow through the injector. For dual fuel operation, as opposed to diesel, high load does not necessarily imply a high flow of diesel through the injector nozzle.This research investigated the factors causing high injector tip temperatures in a DDF engine and the underlying mechanisms which transfer heat to and from the injector tip. Parameter sweeps of each influential parameter were carried out and evaluated. In addition to this, a simple and useful model was constructed based on the heat balance of the injector tip.Decreasing the thermal resistance between the injector tip and the cooling water by inserting a copper sleeve around the injector tip has the potential to greatly reduce the injector tip temperature and effectively remove it as a limiting factor.
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| 9. |
- Stålhammar, Fredrik, et al.
(författare)
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Photon-counting computed tomography for paediatric congenital heart defects yields images of high diagnostic quality with low radiation doses at both 70 kV and 90 kV
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Ingår i: Pediatric Radiology. - 0301-0449.
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Tidskriftsartikel (refereegranskat)abstract
- Background: Photon-counting computed tomography (PCCT) is a new clinical method that may show better diagnostic quality at lower radiation doses than conventional CT. Objective: To investigate the diagnostic quality and radiation dose of paediatric cardiovascular PCCT for diagnosis of congenital heart defects at 70 kV and 90 kV. Materials and methods: This retrospective assessment included clinical non-gated paediatric PCCT examinations for assessment of congenital heart defects. Radiation doses were recorded, and overall and specific diagnostic quality (1–4) were scored by four paediatric radiologists. Agreement, differences, and trends were assessed by percent rater agreement, intraclass correlation, Mann–Whitney tests, and Jonckheere-Terpstra tests. Results: Seventy children with congenital heart defects were examined at 70 kV (n = 35; age 2 days–16 years; 63% boys) or 90 kV (n = 35; age 2 days–17 years; 51% boys). All observers gave a median score of 4 (high diagnostic quality) for both 70 kV and 90 kV, with no difference in median values between tube voltages (all P > 0.06). Agreement for overall scores was 66–94% for 70 kV and 60–77% for 90 kV. Agreement for specific scores was 80–97% for 70 kV and 83–89% for 90 kV. Size-dependent dose estimate was 0.68 mGy (0.25–2.02 mGy) for 70 kV and 1.10 mGy (0.58–2.71 mGy; P < 0.001) for 90 kV. Effective dose was 0.30 mSv (0.15–0.82 mSv) for 70 kV and 0.39 mSv (0.22–1.51 mSv; P = 0.01) for 90 kV. Conclusion: Paediatric cardiovascular PCCT yields images for congenital heart defects of high diagnostic quality with low radiation dose at both 70 kV and 90 kV.
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| 10. |
- Tesi, Bianca, et al.
(författare)
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Diagnostic yield and clinical impact of germline sequencing in children with CNS and extracranial solid tumors : a nationwide, prospective Swedish study
- 2024
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Ingår i: The Lancet Regional Health. - : Elsevier. - 2666-7762. ; 39
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundChildhood cancer predisposition (ChiCaP) syndromes are increasingly recognized as contributing factors to childhood cancer development. Yet, due to variable availability of germline testing, many children with ChiCaP might go undetected today. We report results from the nationwide and prospective ChiCaP study that investigated diagnostic yield and clinical impact of integrating germline whole-genome sequencing (gWGS) with tumor sequencing and systematic phenotyping in children with solid tumors.MethodsgWGS was performed in 309 children at diagnosis of CNS (n = 123, 40%) or extracranial (n = 186, 60%) solid tumors and analyzed for disease-causing variants in 189 known cancer predisposing genes. Tumor sequencing data were available for 74% (227/309) of patients. In addition, a standardized clinical assessment for underlying predisposition was performed in 95% (293/309) of patients.FindingsThe prevalence of ChiCaP diagnoses was 11% (35/309), of which 69% (24/35) were unknown at inclusion (diagnostic yield 8%, 24/298). A second-hit and/or relevant mutational signature was observed in 19/21 (90%) tumors with informative data. ChiCaP diagnoses were more prevalent among patients with retinoblastomas (50%, 6/12) and high-grade astrocytomas (37%, 6/16), and in those with non-cancer related features (23%, 20/88), and ≥2 positive ChiCaP criteria (28%, 22/79). ChiCaP diagnoses were autosomal dominant in 80% (28/35) of patients, yet confirmed de novo in 64% (18/28). The 35 ChiCaP findings resulted in tailored surveillance (86%, 30/35) and treatment recommendations (31%, 11/35).InterpretationOverall, our results demonstrate that systematic phenotyping, combined with genomics-based diagnostics of ChiCaP in children with solid tumors is feasible in large-scale clinical practice and critically guides personalized care in a sizable proportion of patients.
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| 11. |
- Tesi, Bianca, et al.
(författare)
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Diagnostic yield and clinical impact of germline sequencing in children with CNS and extracranial solid tumors : a nationwide, prospective Swedish study
- 2024
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Ingår i: The Lancet Regional Health. - : Elsevier. - 2666-7762. ; 39
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Tidskriftsartikel (refereegranskat)abstract
- Background: Childhood cancer predisposition (ChiCaP) syndromes are increasingly recognized as contributing factors to childhood cancer development. Yet, due to variable availability of germline testing, many children with ChiCaP might go undetected today. We report results from the nationwide and prospective ChiCaP study that investigated diagnostic yield and clinical impact of integrating germline whole-genome sequencing (gWGS) with tumor sequencing and systematic phenotyping in children with solid tumors.Methods: gWGS was performed in 309 children at diagnosis of CNS (n = 123, 40%) or extracranial (n = 186, 60%) solid tumors and analyzed for disease-causing variants in 189 known cancer predisposing genes. Tumor sequencing data were available for 74% (227/309) of patients. In addition, a standardized clinical assessment for underlying predisposition was performed in 95% (293/309) of patients.Findings: The prevalence of ChiCaP diagnoses was 11% (35/309), of which 69% (24/35) were unknown at inclusion (diagnostic yield 8%, 24/298). A second-hit and/or relevant mutational signature was observed in 19/21 (90%) tumors with informative data. ChiCaP diagnoses were more prevalent among patients with retinoblastomas (50%, 6/12) and high-grade astrocytomas (37%, 6/16), and in those with non-cancer related features (23%, 20/88), and ≥2 positive ChiCaP criteria (28%, 22/79). ChiCaP diagnoses were autosomal dominant in 80% (28/35) of patients, yet confirmed de novo in 64% (18/28). The 35 ChiCaP findings resulted in tailored surveillance (86%, 30/35) and treatment recommendations (31%, 11/35).Interpretation: Overall, our results demonstrate that systematic phenotyping, combined with genomics-based diagnostics of ChiCaP in children with solid tumors is feasible in large-scale clinical practice and critically guides personalized care in a sizable proportion of patients.Funding: The study was supported by the Swedish Childhood Cancer Fund and the Ministry of Health and Social Affairs.
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| 12. |
- Öhman, Fredrik, et al.
(författare)
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Demographically adjusted Rey-Osterrieth Complex Figure Test norms in a Swedish and Norwegian cohort aged 49-77years and comparison with North American norms.
- 2024
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Ingår i: Scandinavian journal of psychology. - 1467-9450. ; 65:2, s. 168-178
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Tidskriftsartikel (refereegranskat)abstract
- The Rey-Osterrieth Complex Figure Test (RCFT) is one of the most commonly used neuropsychological tests in Sweden and Norway. However, no publications provide normative data for this population. The objective of this study was to present demographically adjusted norms for a Swedish and Norwegian population and to evaluate these in an independent comparison group.The RCFT was administrated to 344 healthy controls recruited from the Swedish Gothenburg MCI study, the Norwegian Dementia Disease Initiation study, and the Swedish Cardiopulmonary Bioimage Study. Age ranged from 49 to 77years (mean=62.4years, SD=5.0years), and education ranged from 6 to 24years (mean=13.3years, SD=3.0years). Using a regression-based procedure, we investigated the effects of age, sex, and years of education on test performance. We compared and evaluated our Swedish and Norwegian norms with North American norms in an independent comparison group of 145 individuals.In healthy controls, age and education were associated with performance on the RCFT. When comparing normative RCFT performance in an independent comparison group, North American norms generally overestimated immediate and delayed recall performance. In contrast, our Swedish and Norwegian norms appear to better take into account factors of age and education.We presented demographically adjusted norms for the RCFT in a Swedish and Norwegian sample. This is the first normative study of the RCFT that presents normative data for this population. In addition, we showed that North American norms might produce inaccurate normative estimations in an independent comparison group.
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