| 1. |
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Overview of the JET results
- 2015
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 55:10
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Tidskriftsartikel (refereegranskat)
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| 2. |
- Ruilope, LM, et al.
(författare)
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Design and Baseline Characteristics of the Finerenone in Reducing Cardiovascular Mortality and Morbidity in Diabetic Kidney Disease Trial
- 2019
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Ingår i: American journal of nephrology. - : S. Karger AG. - 1421-9670 .- 0250-8095. ; 50:5, s. 345-356
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Tidskriftsartikel (refereegranskat)abstract
- <b><i>Background:</i></b> Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. <b><i>Patients and</i></b> <b><i>Methods:</i></b> The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate ≥25 mL/min/1.73 m<sup>2</sup> and albuminuria (urinary albumin-to-creatinine ratio ≥30 to ≤5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level α = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. <b><i>Conclusions:</i></b> FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049.
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| 3. |
- Abel, I, et al.
(författare)
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Overview of the JET results with the ITER-like wall
- 2013
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 53:10, s. 104002-
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Tidskriftsartikel (refereegranskat)abstract
- Following the completion in May 2011 of the shutdown for the installation of the beryllium wall and the tungsten divertor, the first set of JET campaigns have addressed the investigation of the retention properties and the development of operational scenarios with the new plasma-facing materials. The large reduction in the carbon content (more than a factor ten) led to a much lower Z(eff) (1.2-1.4) during L- and H-mode plasmas, and radiation during the burn-through phase of the plasma initiation with the consequence that breakdown failures are almost absent. Gas balance experiments have shown that the fuel retention rate with the new wall is substantially reduced with respect to the C wall. The re-establishment of the baseline H-mode and hybrid scenarios compatible with the new wall has required an optimization of the control of metallic impurity sources and heat loads. Stable type-I ELMy H-mode regimes with H-98,H-y2 close to 1 and beta(N) similar to 1.6 have been achieved using gas injection. ELM frequency is a key factor for the control of the metallic impurity accumulation. Pedestal temperatures tend to be lower with the new wall, leading to reduced confinement, but nitrogen seeding restores high pedestal temperatures and confinement. Compared with the carbon wall, major disruptions with the new wall show a lower radiated power and a slower current quench. The higher heat loads on Be wall plasma-facing components due to lower radiation made the routine use of massive gas injection for disruption mitigation essential.
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| 4. |
- Romanelli, F, et al.
(författare)
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Overview of the JET results
- 2011
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 51:9
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Tidskriftsartikel (refereegranskat)abstract
- Since the last IAEA Conference JET has been in operation for one year with a programmatic focus on the qualification of ITER operating scenarios, the consolidation of ITER design choices and preparation for plasma operation with the ITER-like wall presently being installed in JET. Good progress has been achieved, including stationary ELMy H-mode operation at 4.5 MA. The high confinement hybrid scenario has been extended to high triangularity, lower ρ*and to pulse lengths comparable to the resistive time. The steady-state scenario has also been extended to lower ρ*and ν*and optimized to simultaneously achieve, under stationary conditions, ITER-like values of all other relevant normalized parameters. A dedicated helium campaign has allowed key aspects of plasma control and H-mode operation for the ITER non-activated phase to be evaluated. Effective sawtooth control by fast ions has been demonstrated with3He minority ICRH, a scenario with negligible minority current drive. Edge localized mode (ELM) control studies using external n = 1 and n = 2 perturbation fields have found a resonance effect in ELM frequency for specific q95values. Complete ELM suppression has, however, not been observed, even with an edge Chirikov parameter larger than 1. Pellet ELM pacing has been demonstrated and the minimum pellet size needed to trigger an ELM has been estimated. For both natural and mitigated ELMs a broadening of the divertor ELM-wetted area with increasing ELM size has been found. In disruption studies with massive gas injection up to 50% of the thermal energy could be radiated before, and 20% during, the thermal quench. Halo currents could be reduced by 60% and, using argon/deuterium and neon/deuterium gas mixtures, runaway electron generation could be avoided. Most objectives of the ITER-like ICRH antenna have been demonstrated; matching with closely packed straps, ELM resilience, scattering matrix arc detection and operation at high power density (6.2 MW m-2) and antenna strap voltages (42 kV). Coupling measurements are in very good agreement with TOPICA modelling. © 2011 IAEA, Vienna.
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| 5. |
- Goryl, P. P., et al.
(författare)
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Tango based control system at SOLARIS Synchrotron
- 2016
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Ingår i: IPAC 2016 - Proceedings of the 7th International Particle Accelerator Conference. - 9783954501472 ; , s. 4101-4103
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Konferensbidrag (refereegranskat)abstract
- A National Synchrotron Radiation Centre SOLARIS has been recently built in Krakow, Poland. The accelera tor is in commissioning phase. The control system is in operation and provides all functionalities required for the commissioning process. The system is based on Tango Controls and has been developed with strong collabora tion with MAX-IV, Lund Sweden and the Tango Commu nity. Protections systems uses Rockwell and Siemens PLC hardware. Synchronization system is based on the MRF hardware. Status, technologies and performance experience will be presented.
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| 6. |
- Falchetto, G. L., et al.
(författare)
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The European Integrated Tokamak Modelling (ITM) effort: achievements and first physics results
- 2014
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 54:4
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Tidskriftsartikel (refereegranskat)abstract
- A selection of achievements and first physics results are presented of the European Integrated Tokamak Modelling Task Force (EFDA ITM-TF) simulation framework, which aims to provide a standardized platform and an integrated modelling suite of validated numerical codes for the simulation and prediction of a complete plasma discharge of an arbitrary tokamak. The framework developed by the ITM-TF, based on a generic data structure including both simulated and experimental data, allows for the development of sophisticated integrated simulations (workflows) for physics application.The equilibrium reconstruction and linear magnetohydrodynamic (MHD) stability simulation chain was applied, in particular, to the analysis of the edgeMHDstability of ASDEX Upgrade type-I ELMy H-mode discharges and ITER hybrid scenario, demonstrating the stabilizing effect of an increased Shafranov shift on edge modes. Interpretive simulations of a JET hybrid discharge were performed with two electromagnetic turbulence codes within ITM infrastructure showing the signature of trapped-electron assisted ITG turbulence. A successful benchmark among five EC beam/ray-tracing codes was performed in the ITM framework for an ITER inductive scenario for different launching conditions from the equatorial and upper launcher, showing good agreement of the computed absorbed power and driven current. Selected achievements and scientific workflow applications targeting key modelling topics and physics problems are also presented, showing the current status of the ITM-TF modelling suite.
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| 7. |
- Kalupin, D., et al.
(författare)
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Numerical analysis of JET discharges with the European Transport Simulator
- 2013
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 53:12, s. article nr. 123007-
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Tidskriftsartikel (refereegranskat)abstract
- The 'European Transport Simulator' (ETS) (Coster et al 2010 IEEE Trans. Plasma Sci. 38 2085-92, Kalupin et al 2011 Proc. 38th EPS Conf. on Plasma Physics (Strasbourg, France, 2011) vol 35G (ECA) P. 4.111) is the new modular package for 1D discharge evolution developed within the EFDA Integrated Tokamak Modelling (ITM) Task Force. It consists of precompiled physics modules combined into a workflow through standardized input/output data structures. Ultimately, the ETS will allow for an entire discharge simulation from the start up until the current termination phase, including controllers and sub-systems. The paper presents the current status of the ETS towards this ultimate goal. It discusses the design of the workflow, the validation and verification of its components on the example of impurity solver and demonstrates a proof-of-principles coupling of a local gyrofluid model for turbulent transport to the ETS. It also presents the first results on the application of the ETS to JET tokamak discharges with the ITER like wall. It studies the correlations of the radiation from impurity to the choice of the sources and transport coefficients.
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| 8. |
- Coreno, M., et al.
(författare)
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Vis-UV fluorescence studies of fragments resulting from the relaxation of molecular core hole states
- 2007
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Ingår i: Physica Scripta. - 0031-8949 .- 1402-4896. ; 76:3, s. C90-C95
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Tidskriftsartikel (refereegranskat)abstract
- The absorption of soft x-ray radiation induces neutral and ionic core hole states in molecules. The relaxation of such states typically leads to a multi-step process, at the end of which photons in the visible and UV range can also be emitted from fragments. In this paper, we present results on Balmer and Lyman emission that originates from excited H atoms produced at the K-edge of the water, ammonia and methane molecules. Dissociation pathways leading to fluorescence emission are discussed.
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| 9. |
- Grochowski, CM, et al.
(författare)
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Deciphering genomic inversions
- 2020
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Ingår i: EUROPEAN JOURNAL OF HUMAN GENETICS. - 1018-4813. ; 28:SUPPL 1, s. 117-118
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 10. |
- Ruiz, J. M., et al.
(författare)
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Selective excitation of the np sigma(1)Sigma(+)(u) and np pi(1)Pi(u) to E,F (1)Sigma(+)(g) emission systems in molecular hydrogen using synchrotron radiation
- 2004
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Ingår i: Chemical Physics Letters. - : Elsevier BV. - 0009-2614 .- 1873-4448. ; 388:03-jan, s. 31-35
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Tidskriftsartikel (refereegranskat)abstract
- The npsigma(1)Sigma(u)(+) and nppi(1)Pi(u) states in H-2 have been selectively excited using monoenergetic synchrotron light in the range 14.4-15.5 eV and the subsequent emission was observed using a grating spectrometer. In total 22 well separated bands of the npsigma(1)Sigma(u)(divided by) and nppi(1)Pi(u) to E,F (1)Sigma(g)(divided by) systems (n = 3-7) were observed and rotationally analysed. The intensities of the P and R branches relative to the Q branch vary strongly in the nppi to EF bands confirming the existence of predissociations of a large number of nppi(1)Pi(divided by) levels. Energy levels of the E,F (1) Sigma(g)(divided by) state (v(EF) = 0, 1, 3, 6-10) are obtained which confirm earlier determinations from other H-2 experiments.
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| 11. |
- Bocchetta, Carlo, et al.
(författare)
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Project Status of the Polish Synchrotron Radiation Facility Solaris
- 2011
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Ingår i: Proceedings of IPAC2011. - 9789290833666 ; , s. 3014-3016
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Abstract in Undetermined The Polish synchrotron radiation facility Solaris is being built at the Jagiellonian University in Krakow. The project is based on an identical copy of the 1.5 GeV storage ring being concurrently built for the MAX IV project in Lund, Sweden. A general description of the facility is given together with a status of activities. Unique features associated with Solaris are outlined, such as infrastructure, the injector and operational characteristics.
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| 12. |
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| 13. |
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| 14. |
- Kukk, E., et al.
(författare)
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Dissociation of deuteromethane following carbon 1s core ionization
- 2002
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Ingår i: Physical Review A. Atomic, Molecular, and Optical Physics. - 1050-2947 .- 1094-1622. ; 66:1
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Tidskriftsartikel (refereegranskat)abstract
- Energy-resolved electron-ion coincidence spectra of the deuteromethane molecule were measured following ionization by narrow-band synchrotron radiation. The ion mass spectra were recorded in coincidence with the outer and inner valence photoelectrons and with the normal Auger electrons from the decay of the carbon 1s core hole. Complementary noncoincidence ion mass spectra were measured below and above the C 1s threshold. The fragmentation patterns of the singly and doubly ionized deuteromethane under different ionization conditions are examined. Carbon core ionization is shown to open new photodissociation pathways not available in the valence ionization photon energy regime. With the aid of ab initio quantum chemistry calculations, a two-step model of the dissociation following core ionization is proposed, showing a good agreement with the experimental findings.
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| 15. |
- Kunze, M, et al.
(författare)
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Recommendations to Improve Tick-Borne Encephalitis Surveillance and Vaccine Uptake in Europe
- 2022
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Ingår i: Microorganisms. - : MDPI AG. - 2076-2607. ; 10:7
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Tidskriftsartikel (refereegranskat)abstract
- There has been an increase in reported TBE cases in Europe since 2015, reaching a peak in some countries in 2020, highlighting the need for better management of TBE risk in Europe. TBE surveillance is currently limited, in part, due to varying diagnostic guidelines, access to testing, and awareness of TBE. Consequently, TBE prevalence is underestimated and vaccination recommendations inadequate. TBE vaccine uptake is unsatisfactory in many TBE-endemic European countries. This review summarizes the findings of a scientific workshop of experts to improve TBE surveillance and vaccine uptake in Europe. Strategies to improve TBE surveillance and vaccine uptake should focus on: aligning diagnostic criteria and testing across Europe; expanding current vaccine recommendations and reducing their complexity; and increasing public education of the potential risks posed by TBEV infection.
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| 16. |
- Marendziak, A., et al.
(författare)
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Residual gas in the vacuum system of the solaris 1.5 GeV electron storage ring
- 2017
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Ingår i: IPAC 2017 - Proceedings of the 8th International Particle Accelerator Conference. - 9783954501823 ; , s. 2734-2737
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Konferensbidrag (refereegranskat)abstract
- Solaris is a third generation light source constructed at the Jagiellonian University in Krakow, Poland. The machine was designed by the MAX IV Laboratory team. The replica of the 1.5 GeV storage ring with 96 m circumference of a vacuum system was successfully built and now the synchrotron facility is after the 3rd phase of commissioning. Recent installation of the Residual Gas Analyzer (RGA) in the storage ring allows now for evaluation of the residual gas composition. Within this paper the result of residual gas analysis in the vacuum system of storage ring during different states of the machine will be presented. Result of vacuum performance regarding beam cleaning and beam lifetime will be presented. Moreover, the NEG strips performance will be evaluated and reported.
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| 17. |
- Wabnitz, H., et al.
(författare)
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Generation of attosecond pulses in molecular nitrogen
- 2006
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Ingår i: European Physical Journal D. Atomic, Molecular, Optical and Plasma Physics. - : Springer Science and Business Media LLC. - 1434-6060. ; 40:2, s. 305-311
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Tidskriftsartikel (refereegranskat)abstract
- We have generated attosecond pulse trains in an ensemble of randomly aligned nitrogen molecules. Measurements of the high-order harmonic relative phases and amplitudes allow us to reconstruct the temporal profile of the attosecond pulses. We show that in the considered spectral range, the latter is very similar to the pulse train generated in argon under the same conditions. We discuss the possible influence of the molecular structure in the generation process, and how it can induce subtle differences on the relative phases.
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| 18. |
- Yeung, Andy Wai Kan, et al.
(författare)
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Dietary natural products and their potential to influence health and disease including animal model studies
- 2018
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Ingår i: Animal Science Papers and Reports. - : POLSKA AKAD NAUK, INST GENETYKI I HODOWLI ZWIERZAT. - 0860-4037. ; 36:4, s. 345-358
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Forskningsöversikt (refereegranskat)abstract
- Although biological and pharmacological effects of dietary natural products have been intensively studied, there has been no bibliometric analysis performed on this research field up to now. The current study has aimed to identify and analyze the manuscripts on dietary natural products and their potential to influence health and disease including studies using animal models. Data, including words from titles and abstracts, publication and citation data, have been extracted from Web of Science database and analyzed by the VOSviewer software. Our search has yielded 1,014 manuscripts. The ratio of original articles to reviews was identified to be 1.5:1. Over half of the manuscripts have been published since 2010. The manuscripts have been contributed by 4,301 authors from 1,445 organizations in 76 countries/territories and published in 499 journals. The results from the current study point out that scientific research focusing on the potential of dietary natural products to affect health and disease status (including animal model studies) is expanding, and suggests an increasing significance of this scientific area. With the progressive development and improvement of animal studies, it should be expected that animal models of different human diseases (especially civilization ones) would be an integral part of the research for the evaluation of pharmaceuticals originated from dietary natural products like plants or plant materials. Moreover, natural products can also be fed to animals to improve the quality of animal products, with numerous resulting functional effects.
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| 19. |
- Erman, P., et al.
(författare)
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Non Franck-Condon effects in photoionization of molecular oxygen
- 2000
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Ingår i: Physica scripta. T. - 0281-1847. ; 62:4, s. 294-300
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Tidskriftsartikel (refereegranskat)abstract
- We present a theoretical and experimental analysis of non Franck-Condon effects in photoionization to the b (4)Sigma(g)(-), state of O-2(+). Experimentally, by dispersing the synchrotron radiation induced O-2(+) b (4)Sigma(g)(-) a (IIu)-I-4 fluorescence we derive the b (4)Sigma(g)(-), State vibrational branching ratios in the excitation energy range 21-34 eV. The vibrational branching ratios reveal features in the region 21-28 eV indicating strong non Franck-Condon effects. The experimental results have been analysed by computing ab initio the vibrational population branching ratios using a many-body perturbation method. Additionally the autoionizing neutral states existing in this energy region have been studied. We have computed the energies of the valence states up to an energy of 30 eV their transition moments for excitations from the ground state, and autoionization rates. Our calculations show, that strong non Franck-Condon effects recorded in the branching ratio spectrum (below 25 eV) are actually caused by the narrow 3 sigma(g) --> sigma(u) shape resonance, and its coupling to the 1 pi(u) --> pi(g) channel.
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| 20. |
- Karawajczyk, A., et al.
(författare)
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Neutral fragmentation of superexcited oxygen molecules
- 2000
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Ingår i: Physical Review A. Atomic, Molecular, and Optical Physics. - 1050-2947 .- 1094-1622. ; 61:3, s. art. no.-32718
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Tidskriftsartikel (refereegranskat)abstract
- The mechanisms of neutral dissociation of oxygen molecules in the excitation energy range 15-25 eV have been studied in a dispersed fluorescence experiment. By detecting the fluorescence from excited oxygen atoms, we find that neutral superexcited O-2 states below 20 eV dissociate into O(g.s.) + O(3s,3p). At higher excitation energies (h nu = 20-25 eV) the curve-crossing interactions following excitations to members of the Rydberg c (4)Sigma(u)(-) series also yield atoms in Rydberg states (nl,n greater than or equal to 4). The experimental data are analyzed on the ground of many-body perturbation theory, calculations which indicate the structure of the predissociating states converging to the experimentally observed ones.
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| 21. |
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| 22. |
- Stankiewicz, M., et al.
(författare)
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Relaxation dynamics of SF6 studied by energy-resolved electron ion coincidence technique
- 2004
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Ingår i: Journal of Electron Spectroscopy and Related Phenomena. - : Elsevier BV. - 0368-2048 .- 1873-2526. ; 137-40, s. 369-375
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Tidskriftsartikel (refereegranskat)abstract
- The mass spectra from the SF6 molecule acquired by energy-resolved electron ion coincidence (EREICO) technique using (1t(1g) + [5t(1u),1t(2u)]), (3e(g) + 1t(2g)), 4t(1u), and 5a(1g) electrons after both valence and S 2p(-1) 6a(1g) core excitation reveal a strong selectivity in the dissociation from these states. From the comparison of the obtained spectra, the influence of the core-excited state in the relaxation pathway of the molecule is studied. The S 2p --> 6a(1g) core excitation does not affect the relaxation dynamics after participator Auger decay to the (1t(1g) + [5t(1u),1t(2u)])(-1) and (4t(1u))(-l) states, but it alters the relaxation dynamics after participator Auger decay to the (3e(g) + 1t(2g))(-1) and (5a(1g))(-1) states with respect to the decay processes after direct excitation of the same orbitals. These observations point to core excitation induced dissociation in the SF6 molecule.
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