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| 20. |
- Siljebo, Josef, et al.
(författare)
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School leadership in a digitalized society : Reflections on the Use of a Survey Tool for Improving Educational Practice
- 2021
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Ingår i: ECER programmes.
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Konferensbidrag (refereegranskat)abstract
- This presentation will report from a pilot study using a novel quantitative instrument as a mean for findings of scientific relevance as well as of relevance for school development. The aim of the pilot study was to better understand school leadership in the midst of digitalization in school. The project was based on two theoretical positions for understanding leadership in the context of digitalization: Leadership behaviours according to Yukl (2013) and Cultural Historical Activity Theory (CHAT) according to Engeström, (2015). The essence of leadership in organizations is, according to Yukl (2013),“influencing and facilitating individual and collective efforts to accomplish shared objectives”. Leaders can improve the performance of a team or organization by influencing the processes that determine performance.Background: The Swedish government has commissioned a national pilot project to test sustainable collaboration models between academia and the school or school system regarding research, school activities and teacher education for the period 2017 to 2021 (ulfavtal.se). Expectations are to contribute to the research base of the school system, and to conduct research build on equal terms between researchers and schools. In Sweden there is an explicit expectation in the Education Act, that education is to “rest on a scientific grounds and proven experience” (Section 5). This means that teachers and school leaders are to base the exercise of their profession on research and that school development is to be permeated by a scientific approach. Along this argument, a need to develop sustainable collaboration models between the school system and academia resting on common grounds is formulated as a goal of the pilot project. Similar collaborative approaches between practice and academa are adopted in many European countreis. This means embracing a dimension of development work into the approach to research.The idea of forming collaborations between schools and academia to improve the quality of the educational practice is not new internationally. There is a growing body of initiatives with the aim to connect school improvement with external actors such as universities through networks and collaborative partnerships of different kinds (Chapman et al., 2016). Research shows how this may lead to meaningful changes in the teaching and learning processes in schools (Ainscow, 2012). Literature on initial teacher education, professional development for teachers, and educational research, also acknowledges how school–academia partnerships are powerful collaborations that can result in improved practice and results for students (Day & Smethem, 2010). However, only a limited amount of research tries to understand how such partnerships and collaboration forms stem from strategic leadership (e.g., Murphy, 2017).In this paper we address the issue of better understanding how such collaborations can be built on strategic decisions about content for collaboration, when it comes to digitalization in schools. Digitalization and school leadership: As discussed by Olofsson et al. (2015), school leaders often experience digitalization processes as “challenging and difficult” (p. 117). Chua Reyes (2015) showed that school leaders experience that their role has changed “from leading a team of teachers who have been deliverers of knowledge towards leading a team of teacher facilitators” (2015, p. 378). In Sweden, research on school leadership is rather limited (Ärlestig et al., 2016). Studies at hand argues that leadership is important for implementation of digital visions and reforms (Petersen, 2014). Moreover, that school leaders’ professional development is needed to effectively lead for digitalization in school (cf. Håkansson-Lindqvist & Pettersson, 2019; Pettersson, 2018). In 2012, the Swedish School Inspectorate (Lund, 2012) pointed out that school leaders do not actively lead, and support digitalization and that more knowledge is needed for leading digitalization in school.Method: The quantitative instrument is based on two constructs (1) notions of leadership (based on the survey developed by Yukl, 2013); and (2) levels of expansive learning with digital technology (based on the theoretical foundations found in Engeström, 2015). The first construct is measured in four meta-categories: Task-oriented behaviours, Relations-oriented behaviours, Change-oriented behaviours, and External leadership behaviours. The four meta-categories consist of a total of 17 specific component behaviours, such as Clarifying, Supporting, Advocating change and External monitoring. In total, this part of the survey consists of 49 questions, all modified to address the current state of leadership at the respondent workplace. The second construct is measured in 18 questions related to three levels 1) how respondents use digital technologies in their daily work, 2) how the use has changed the daily practice, and 3) how the use has changed the way they work, communicate, and operate in the entire organization. The questions concern to what degree the use of digital technologies has developed new ways of organising and talking about daily practice. Item are designed as fixed-response format (Wilson, 2005) and responses are on a Likert-type scale ranging from 1 (not relevant) to 5 (absolutely essential). A series of background questions of relevance for the different constructs are also asked. The instrument is available online and will be administered as an online self-administered questionnaire. In this pilot study, the survey was distributed to all school leaders in one municipality in the northern Sweden (N = 44 with a response rate of 90 %). As can be seen, the total number of school leaders in municipalities in this region is low, but the tests have been made covering the total number of respondents possible. As such, awareness of this challenge is kept in mind in terms of analysis and inferences possible by use of the data.Expected Outcomes: The possibilities for the results of the survey to be used as a basis for school development is discussed, as is the possibilities for the approach to be a way of conducting research, and thus also development work of relevance for school practice with the outspoken intention to improve the quality of the educational practice. Even if the data at the moment is not fully analyzed yet, there are some interesting trends in the material. For instance, due to the participant school leaders, Task-oriented and Relations-oriented leadership behaviours are more important than Change-oriented behaviours, when it comes to leading digitalization in school. There are also some interesting discrepancies between what is judged as important for their school organisations on one hand, and what is important in their leadership on the other. These trends seem to be of importance for strategic decisions about content for continous collaboration, and thereby for school development when it comes to digitalization in school. For the approach to be a collaboration form that provide genuine possibilities for research to be the scientific ground that educational quality should rest on, as is intended in the education act, there are a number of possibilities as well as challenges such as the inconsistency of the educational practice as such and the contextual boundaries of knowledge of what works and improve the quality of practice.
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| 21. |
- Stark, Katarina, 1975-
(författare)
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Catalytic Properties and Tissue Distribution of Cytochrome P450 4F8 and 4F12 : Expression of CYP4F8 in Eye Tissues and Psoriatic Lesions
- 2005
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The human cytochrome P450 (CYP) family of monooxygenases is important for metabolism of drugs and endogenous compounds, e.g., vitamin A and D, cholesterol, steroids, fatty acids, and eicosanoids. This thesis describes the tissue distribution, catalytic properties, and possible function of CYP4F8 and CYP4F12. To this respect, methods for immunohistological analysis, and real-time PCR for analysis of their transcripts, were developed.CYP4F8 was originally cloned from human seminal vesicles and proposed to catalyze 19-hydroxylation of prostaglandin H2 (PGH2). This notion could now be supported, as cyclooxygenase-2, CYP4F8, and microsomal prostaglandin E synthase-1 were found to be co-localized in the epithelial linings of seminal vesicles. The three enzymes were also co-localized in the suprabasal layers of epidermis, suggesting a similar function of CYP4F8 in skin. Real-time PCR showed that CYP4F8 mRNA was more than 10-fold increased in psoriatic lesions compared to non-lesional skin. CYP4F8 immunoreactivity was also found in kidney cortex, transitional epithelium, corneal epithelium, and retina. Although transcripts of all three enzymes were detectable in retina, no co-localization was found. Pro inflammatory stimuli were found to increase CYP4F8 mRNA expression in cultured epidermal and corneal keratinocytes. In these tissues CYP4F8 might oxidize fatty acids or other eicosanoids than PGH2.CYP4F12 was originally cloned from the liver and small intestine, and found to oxidize arachidonic acid and two anti-histamines. Immunohistological studies showed that CYP4F12 immunoreactivity was present mainly in the gastrointestinal tract, e.g., stomach, ilium, and colon, but also in placenta. Although CYP4F8 and CYP4F12 have catalytic properties in common, there are important differences. CYP4F12 does not oxidize PGH2, certain eicosanoids, and fatty acids. The prominent expression in the gut suggests that CYP4F12 might be involved in oxidation of drugs.
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| 22. |
- Stark, Katarina, et al.
(författare)
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Co-localization of COX-2, CYP4F8 and mPGES-1 in epidermis with prominent expression of CYP4F8 mRNA in psoriatic lesions
- 2006
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Ingår i: Prostaglandins & other lipid mediators. - : Elsevier BV. - 1098-8823 .- 2212-196X. ; 79:1-2, s. 114-125
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Cyclooxygenase-2 (COX-2), cytochrome P450 4F8 (CYP4F8), and microsomal PGE synthase-1 (mPGES-1) form PGE and 19-hydroxy-PGE in human seminal vesicles. We have examined COX-2, CYP4F8, and mPGES-1 in normal skin and in psoriasis. All three enzymes were detected in epidermis by immunofluorescence and co-localized in the suprabasal cell layers. In lesional psoriasis the enzymes were also co-localized in the basal cell layers. Real-time RT-PCR analysis suggested that CYP4F8 mRNA was induced 15-fold in lesional compared to non-lesional epidermis. mRNA of all enzymes were present in cultured HEK and HaCaT cells, but the prominent induction of CYP4F8 mRNA in psoriasis could not be mimicked by treatment of these keratinocytes with a mixture of inflammatory cytokines or with phorbol 12-myristate-13-acetate. The function of CYP4F8 in epidermis might be related to lipid oxidation and keratinocyte proliferation.
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| 26. |
- Stark, Katarina, et al.
(författare)
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Expression of CYP4F12 in gastrointestinal and urogenital epithelia
- 2004
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Ingår i: Basic & Clinical Pharmacology & Toxicology. - : Wiley. - 1742-7835 .- 1742-7843. ; 94:4, s. 177-83
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Cytochrome P450 4F12 (CYP4F12) was originally cloned from human liver and small intestine. CYP4F12 can oxidize arachidonic acid, two stable prostaglandin H2 analogues, and an antihistamine, ebastine, but the tissue distribution and catalytic properties of CYP4F12 have not been fully investigated. An antipeptide polyclonal antibody was raised against the C-terminal of CYP4F12 (PLNVGLQ), evaluated by Western blot analysis and used for immunohistological analysis of 50 human tissues. Western blot analysis of recombinant CYP4F12, expressed in yeast, and microsomal proteins from adult and foetal liver, kidney, placenta at term, seminal vesicles, the prostate gland and purified prostasomes showed that the polyclonal antibody detected a protein of the expected size, approximately 60 kDa. CYP4F12 mRNA could be detected in seminal vesicles and prostate gland by reverse transcription-PCR. Prominent CYP4F12 immunoreactivity occurred, inter alia, in the epithelial cells of the gastrointestinal tract (stomach, small intestine, and colon), collecting tubules, transitional epithelium, ovarian follicles, the endothelium of microvessels of placental villi (first trimester), and epidermis. We screened recombinant CYP4F12 for catalytic activity. Arachidonic acid (20:4n-6) was hydroxylated at C18 and laurate at C11, but significant amounts of metabolites of 18:2n-6, 20:3n-9, 20:5n-3, 22:5n-6, and some prostaglandins could not be detected. We conclude that CYP4F12 is widely distributed in gastrointestinal and urogenital epithelia and exhibits a narrow substrate specificity.
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| 27. |
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| 28. |
- Stark, Katarina, et al.
(författare)
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Expression of CYP4F8 (prostaglandin H 19-hydroxylase) in human epithelia and prominent induction in epidermis of psoriatic lesions
- 2003
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Ingår i: Archives of Biochemistry and Biophysics. - 0003-9861 .- 1096-0384. ; 409:1, s. 188-196
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Tidskriftsartikel (refereegranskat)abstract
- Our aim was to determine the tissue distribution of CYP4F8, which occurs in human seminal vesicles and catalyzes 19-hydroxylation of prostaglandin H(1) and H(2) in vitro (J. Bylund, M. Hidestrard, M. Ingelman-Sundberg, E.H. Oliw, J. Biol. Chem. 275 (2000) 21844-21849). Polyclonal antibodies were raised in rabbits against RVEPLG, the C-terminal end of CYP4F8, and purified by affinity chromatography. Screening of 50 human tissues for CYP4F8 immunoreactivity revealed protein expression, inter alia, in seminal vesicles, epidermis, hair follicles, sweat glands, corneal epithelium, proximal renal tubules, and epithelial linings of the gut and urinary tract. The CYP4F8 transcripts were detected by reverse transcription polymerase chain reaction and by Northern blot analysis. There was a prominent induction of CYP4F8 immunoreactivity and mRNA in psoriasis in comparison with unaffected epidermis of the same patients. The cDNA of CYP4F8 from plucked scalp hair roots was identical with the genital cDNA sequence. We conclude that CYP4F8 is present in epithelial linings and up regulated in epidermis of psoriatic lesions.
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| 29. |
- Stark, Katarina, et al.
(författare)
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On the mechanism of biosynthesis of 19-hydroxyprostaglandins of human seminal fluid and expresssion of cyclooxygenase-2, PGH 19-hydroxylas (CYP4F8) and microsomal PGE synthase-1 in seminal vesicles and vas deferens
- 2005
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Ingår i: Prostaglandins & other lipid mediators. - : Elsevier BV. - 1098-8823 .- 2212-196X. ; 75:1-4, s. 47-64
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Tidskriftsartikel (refereegranskat)abstract
- The predominating prostaglandins of human seminal fluid are 19R-hydroxyprostaglandins E1 and E2, conceivably formed sequentially by prostaglandin H (PGH) synthase-2, PGH 19-hydroxylase (CYP4F8), and microsomal PGE synthase-1 of seminal vesicles. Our aim was to study this enzyme system. Quantification by real-time PCR suggested that the transcripts of PGH synthase-2, CYP4F8, and microsomal PGE synthase-1 were abundant and correlated in seminal vesicles of seven patients (p < 0.05). The three enzymes were detected in seminal vesicles by Western blot analysis, and immunohistological analysis confirmed the localization to the epithelia of seminal vesicles and distal vas deferens. Immunofluorescence analysis showed co-localization of the three enzymes in epithelial cells of seminal vesicles and vas deferens. 19-Hydroxy-PGE compounds were detected by mass spectrometry in the mucosa of distal vas deferens. Recombinant CYP4F8 catalyzes n-2 hydroxylation of PGH1 and PGH2 and n-3 hydroxylation of arachidonic acid. Arachidonic acid was oxidized to 18-hydroxyarachidonic acid and to PGE2 and by microsomes of seminal vesicles in the presence of NADPH and GSH, and to relatively small amounts of 19-hydroxy-PGE2. We conclude that PGH synthase-2, CYP4F8, and PGE synthase-1 likely forms 19-hydroxy-PGE compounds in seminal vesicles and vas deferens, but the catalytic properties of CYP4F8 suggest additional biological functions. Recombinant CYP4F8 was also found to catalyze n-2 hydroxylation of PGI2 and carbaprostacyclin (Km to approximately 40 microM), and n-2 and n-3 hydroxylation of carbocyclic TXA2.
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| 33. |
- Öjefors Stark, Katarina, et al.
(författare)
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Daily moderate-intensity physical activities and optimism promote healthy ageing in rural northern Sweden : a cross-sectional study.
- 2021
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Ingår i: International Journal of Circumpolar Health. - : Informa UK Limited. - 1239-9736 .- 2242-3982. ; 80:1
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Tidskriftsartikel (refereegranskat)abstract
- The aim of our study was to explore the association between self-reported health factors and self-rated health (SRH) among an older rural population in northern Sweden and whether confounders optimistic outlook or daily moderate-intensity physical activity could moderate the association between self-reported health factors and SRH, controlling for age. The study is based on a sample (N = 1946) from the “Health on Equal Terms” Västernorrland survey 2018 aged 65–84. Prevalence and multivariate logistic regression analyses were performed. The results indicated most rural older people perceived very good or good SRH, though physical and mental health issues and impaired mobility increased with advanced age. Mental well-being exhibited a stronger association with poor SRH than physical health or impaired mobility. In addition, confounders optimistic outlook and daily moderate-intensity physical activity, separately and together could moderate the association between health factors and poor SRH. In conclusion, older people in a rural setting perceived good health, despite common physical and mental health issues. Promoting daily moderate-intensity physical activity and activities contributing to an optimistic outlook can protect against poor SRH in old age.
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| 34. |
- Öjefors Stark, Katarina, et al.
(författare)
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Regional perspectives on remote teaching in Sweden
- 2020
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Ingår i: Education in the North. - Aberdeen : School of Education at the University of Aberdeen. - 0424-5512 .- 2398-0184. ; 27:2, s. 7-23
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Tidskriftsartikel (refereegranskat)abstract
- In rural parts of Sweden, there is a growing interest in remote teaching, i.e. synchronous teaching using ICT. The Swedish National Agency for Education views remote teaching as a way to meet teacher shortage. However, there is limited research on remote teaching as an educational form. The purpose of this study was to investigate opportunities and challenges with remote teaching from three perspectives: school, region, and research. The method chosen was content analysis of qualitative interviews with school leaders, regional officials and researchers. All informants ment that remote teaching had great opportunities. Common themes were equality, meeting teacher shortages, access to qualified teachers, and increased teaching quality. However, the informants highlighted challenges related to the technological, practical and organizational issues, learning, and legal issues. Limited use by the Education Act was the foremost challenge according to regional officials and researchers, while school leader more often highlighted technology, pedagogy, and organization as challenges. In conclusion, all three perspectives saw remote teaching as a way to ensure pupils in rural areas the right to equal education and teaching quality. Despite challenges introducing a novel form of teaching, there is a consensus on remote teaching as an integral part of the future school.
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| 35. |
- Aad, G., et al.
(författare)
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- 2015
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Ingår i: Physical Review C (Nuclear Physics). - 0556-2813 .- 1089-490X. ; 92:3
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Tidskriftsartikel (refereegranskat)
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| 36. |
- Aad, G., et al.
(författare)
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- 2012
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Tidskriftsartikel (refereegranskat)
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| 37. |
- Aad, G., et al.
(författare)
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- 2012
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Ingår i: Nuclear Physics, Section B. - : Elsevier BV. - 0550-3213 .- 1873-1562. ; 864:3, s. 341-381
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Tidskriftsartikel (refereegranskat)
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| 38. |
- Aad, G., et al.
(författare)
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- 2015
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Ingår i: Physical Review C (Nuclear Physics). - 0556-2813 .- 1089-490X. ; 92:3
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Tidskriftsartikel (refereegranskat)
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| 39. |
- Aad, G., et al.
(författare)
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- 2013
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Tidskriftsartikel (refereegranskat)
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| 40. |
- Aad, G., et al.
(författare)
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- 2015
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Tidskriftsartikel (refereegranskat)
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| 41. |
- Aad, G., et al.
(författare)
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- 2015
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Ingår i: Physical Review D (Particles, Fields, Gravitation and Cosmology). - 1550-2368 .- 1550-7998. ; 91:11, s. 112011-
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Tidskriftsartikel (refereegranskat)
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| 42. |
- Aad, G., et al.
(författare)
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- 2015
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Ingår i: Physical Review D (Particles, Fields, Gravitation and Cosmology). - 1550-2368 .- 1550-7998. ; 92:1
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Tidskriftsartikel (refereegranskat)
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| 43. |
- Aad, G., et al.
(författare)
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- 2015
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Ingår i: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; :8
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Tidskriftsartikel (refereegranskat)
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| 44. |
- Aad, G., et al.
(författare)
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- 2015
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Tidskriftsartikel (refereegranskat)
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| 45. |
- Aad, G, et al.
(författare)
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- 2014
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Ingår i: Physical Review Letters. - 1079-7114 .- 0031-9007. ; 113:17
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Tidskriftsartikel (refereegranskat)
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