| 1. |
- Steffenburg, Hanna, et al.
(författare)
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Children with autism spectrum disorders and selective mutism
- 2018
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Ingår i: Neuropsychiatric Disease and Treatment. - : Informa UK Limited. - 1178-2021. ; 14, s. 1163-1169
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Tidskriftsartikel (refereegranskat)abstract
- Background: It has been suggested that autism spectrum disorder (ASD) might be a "comorbid" condition in selective mutism (SM). Methods: In this retrospective study, we examined medical records of children with SM diagnosis (n=97) at a medical center specializing in assessment of ASD. Results: Mean age for onset of SM symptoms was 4.5 years and mean age at SM diagnosis was 8.8 years. SM was more common among girls (boy:girl ratio=2.7:1). We found that 63% of the study group had an ASD (no gender difference). The SM group with combined ASD had later onset of symptoms, higher age at diagnosis, more often a history of speech delay, and a higher proportion of borderline IQ or intellectual disability. Conclusion: The results highlight the risk of overlap between ASD and SM.
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| 2. |
- Steffenburg, Suzanne, et al.
(författare)
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Autism in Angelman syndrome: a population-based study.
- 1996
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Ingår i: Pediatric Neurolgy. - 0887-8994. ; 14:2, s. 131-136
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to examine the prevalence of angelman syndrome in prepubertal school-aged children and analyze its comorbidity with autistic disorder. A clinical/psychiatric evaluation of a population-based sample of 6- to 13-year-old mentally retarded children with active epilepsy was performed. Four individuals in a total population of almost 49,000 children conformed to the clinical diagnosis of Angelman syndrome. Two of these had a typical microdeletion at chromosome 15q11-13. The minimum prevalence of Angelman syndrome was estimated at 0.008% (1: 12,000) in the examined age group. All 4 children with Angelman syndrome met full behavioral criteria for the diagnosis of autistic disorder/childhood autism. It is concluded that Angelman syndrome is uncommon, but more frequent than previously estimated. The diagnosis should be considered in all patients with combined autistic disorder, severe mental retardation, and epilepsy. The implications of the possible association of Angelman syndrome and autism are discussed
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| 3. |
- Steffenburg, Suzanne, et al.
(författare)
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Autism spectrum disorders in children with active epilepsy and learning disability: comorbidity, pre- and perinatal background, and seizure characteristic
- 2003
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Ingår i: Developmental Medicine and Child Neurology. - 0012-1622. ; 45:11, s. 724-730
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to examine the comorbidity pattern, seizure characteristics, and aetiology in a representative group of children with a combination of autism spectrum disorder (ASD), active epilepsy, and learning disability. Ninety children (47 males, 43 females; mean age 11 years 2 months, range 8 to 16 years at the time of psychiatric examination) with active epilepsy and learning disability, identified in a population-based study in Göteborg, Sweden, were subdivided into those with and those without ASD and compared with respect to aetiology, additional neuroimpairments, and seizure characteristics. In addition, the cohorts were examined for trends of prevalence over a period of time. Results indicated that established aetiology was much more often present in the prenatal period than in the peri- or postnatal periods in the ASD group. Cerebral palsy and visual impairment were under-represented in the ASD group. Partial seizures tended to be more common and generalized seizures less common in the ASD group compared with the non-ASD group. Seizure onset was later in the ASD group. Many of the significant differences were accounted for by a large group of psychiatrically unclassifiable participants in the non-ASD group. There was no trend towards an increase of affected children over the 12-year period. There was no increase in the prevalence of active epilepsy and learning disability nor in the rate of autism with active epilepsy and learning disability in children born between 1981 and 1986 compared with those born from 1976 to 1980, indicating no statistical association with the general measles-mumps-rubella vaccination introduced in the early 1980s.
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| 4. |
- Steffenburg, Suzanne, et al.
(författare)
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Psychiatric disorders in children and adolescents with mental retardation and active epilepsy.
- 1996
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Ingår i: Archives of Neurology. - 0003-9942. ; 53:9, s. 904-912
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To assess the prevalence and types of psychiatric disorders in a representative sample of school-age children with the combination of mental retardation (MR) and active epilepsy. SUBJECTS AND METHODS: Ninety-eight children were identified with MR and active epilepsy in a population-based study from Göteborg, Sweden, which has a general population at risk of 48873 children. They were born between 1975 and 1986 and were 8 to 16 years old at the time of psychiatric examination. Five children had died, 3 had parents who declined participation, and 90 were clinically examined. RESULTS: Fifty-three children (59%) had at least 1 psychiatric diagnosis, and the conditions in 30 (33%) could not be classified because of profound severe MR. Twenty-four children (27%) had autistic disorder, and another 10 (11%) had an autisticlike condition. The combination of MR, active epilepsy, and autism or an autisticlike condition occurred at a rate of 0.07% in the general population. The most common seizure types in the group with autism or an autisiclike condition were complex partial, atypical absence, myoclonic, and tonic-clonic. CONCLUSIONS: Children with MR and active epilepsy suffered from a psychiatric disorder in a majority of those cases in which the children had enough skills and mobility to exhibit behavioral and emotional problems. Many such problems had been undiagnosed despite parental concern and the conviction that the psychiatric problems were the most burdensome in many cases. Neurologists and psychiatrists need to develop better programs for the adequate management of psychiatric disorders in this population.
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| 5. |
- Beckung, Eva, 1950, et al.
(författare)
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Motor impairments, neurological signs, and developmental level in individuals with Angelman syndrome.
- 2004
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Ingår i: Developmental medicine and child neurology. - 0012-1622. ; 46:4, s. 239-43
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to examine the character of motor dysfunction in individuals with Angelman syndrome (AS). Thirty-three children and adolescents (median age 6 years, range 18 months to 23 years) were consecutively investigated for learning disability, epilepsy, and motor dysfunction to detect suspected AS. Twenty-three individuals (13 males, 10 females; median age 5 years 6 months, range 21 months to 23 years) fulfilled international consensus criteria for AS. Clinical diagnosis was supported by a positive DNA methylation test in eleven participants. Ten participants (seven males, three females; median age six years, range 18 months to 13 years) did not comply with consensus criteria for AS and were regarded as a comparison group. There was no significant difference between the AS and the comparison group regarding age or developmental level. Median developmental quotient level was 26 months (range 8 to 63 months); median gross motor developmental level in participants with AS was 24 months (range 8 to 60 months); median fine motor developmental level was 15 months (range 6 to 60 months). Muscle strength, spasticity, tremor, and coactivation were assessed: distal lower limb spasticity, ataxic like gait, stiff lower limbs, and the presence of coactivation during locomotion were significantly more frequent in participants with AS than in the comparison group (p<0.05). Asymmetry of muscle strength and spasticity were frequent. Neurological abnormalities were insufficient for a diagnosis of cerebral palsy and impeded function less than immaturity in both AS groups. Risk of increasing impairment needs to be anticipated to prevent negative long-term effects of muscle imbalance and motor asymmetries in individuals with AS.
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| 6. |
- Danielsson, Susanna, 1964, et al.
(författare)
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Psychopathology, psychosocial functioning, and IQ before and after epilepsy surgery in children with drug-resistant epilepsy.
- 2009
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Ingår i: Epilepsy & Behavior. - : Elsevier BV. - 1525-5050. ; 14:2, s. 330-337
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Tidskriftsartikel (refereegranskat)abstract
- This is a prospective study of a consecutive series of children undergoing epilepsy surgery. The main aims were to evaluate the heterogeneity with respect to psychopathology and IQ, and to use a global assessment scale (Children's Global Assessment Scale [CGAS]) to evaluate psychosocial functioning. Clinical neuropsychiatric and neuropsychological assessments were made at baseline and at the 2-year follow-up in 24 patients, and changes were analyzed at an individual level. Psychiatric disorders (mainly attention deficit hyperactivity disorder and/or autism spectrum disorders) were found in 17 of 24 at some point. All except one child with psychiatric diagnoses before surgery still had at least one diagnosis at follow-up. Intellectual ability remained stable in the majority of cases, both in individuals with and in individuals without mental retardation. The CGAS illustrated the consequences of the extensive comorbidity in this cohort. The behavioral problems had been undiagnosed despite parental concern in many cases, indicating an unrecognized need for services for children with drug-resistant epilepsy.
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| 7. |
- Gillberg, Christopher, 1950, et al.
(författare)
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Auditory Integration Training in Children with Autism : Brief Report of an Open Pilot Study
- 1997
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Ingår i: Autism. - : SAGE Publications. - 1362-3613 .- 1461-7005. ; 1:1, s. 97-100
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Tidskriftsartikel (refereegranskat)abstract
- Nine children aged 3-I 6 years with an autistic disorder were given auditory integration training for half-hour sessions during 10 days according to guidelines suggested by Guy Berard. No significant change in overall autistic symptom level could be documented 9 months later. However a small but non-significant reduction of 'sensory problems' as rated by the Autism Behaviour Checklist was noted.
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| 8. |
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