| 1. |
- C. Manchaiah, Vinaya K., 1983-, et al.
(författare)
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Information about the prognosis given to sudden-sensorineural hearing loss patients: Implications to 'patient journey' process
- 2012
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Ingår i: Audiological Medicine. - London, UK : Informa Healthcare. - 1651-386X .- 1651-3835. ; 10:3, s. 109-113
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Tidskriftsartikel (refereegranskat)abstract
- Objective: The aim of this short paper is to highlight the implications of information provision about prognosis given to sudden sensorineural hearing loss (SSNHL) patients. Method: Semi-structured interviews were conducted with four SSNHL patients to develop the patient journey model that is published in our previous paper (12). In this study the implications from general, ethical and legal perspectives about the information provision were considered (i.e. discussion with experts and the use of relevant literature). Results: Three out of four patients interviewed reported that their doctors (both general practitioners and ENT specialists) gave false hopes about prognosis. From the preliminary data it appears that there is considerable variability in the views expressed by patients about preference in information provision. However, this issue needs consideration as the information provided by professionals may have a serious impact on service provision and outcome. Conclusions: It is our view that even though, in some instances, it may appear that false hope provides short-term psychological benefit to patients, providing full and honest information is necessary for general (i.e. to facilitate patient journey process), ethical and legal reasons.
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| 2. |
- C. Manchaiah, Vinaya K., 1983-, et al.
(författare)
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Life consequences and positive experiences reported by communication partners of person with hearing impairment: A pilot study
- 2013
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Ingår i: Speech, Language and Hearing. ; 16:1, s. 1-7
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to obtain insights into the life consequences and positive experiences reported by the communication partners (CPs) of person with hearing impairment (PHI). Open-ended questionnaires and semi-structured interviews were conducted with nine CPs who were recruited through the Swansea hearing impaired support group. Data were analyzed using thematic analysis. The results identified a number of life consequences and positive experiences of CPs and PHIs as reported by the CPs. The main life consequences experienced by both CPs and PHIs were related to communication and psychological aspects. The main positive experiences for the CPs were related to personal development and improved relationships and for PHIs were related to the use of hearing loss for self-advantage. Surprisingly, most of the participants were able to identify at least one positive experience. The study also suggested that open-ended questionnaires were a good way to understand life consequences and positive experiences by CPs and such responses can be further elicited by providing some prompts through a semi-structured interview. The study method and results could be useful in involving CPs in audiological enablement/rehabilitation sessions. These findings add to the growing literature that reported positive experiences canbe used during counseling sessions, to motivate the PHIs and their CPs and to boost their positive morale.
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| 3. |
- C. Manchaiah, Vinaya K., 1983-, et al.
(författare)
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Perspectives in defining ‘hearing loss’ and its consequences
- 2013
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Ingår i: Hearing, Balance and Communication.
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Tidskriftsartikel (refereegranskat)abstract
- Objective: This discussion paper aims to highlight factors that may be important in defining hearing loss and its consequences and to present different perspectives based on various models of disability. Method: Relevant literature was reviewed to develop the discussion. Results: Hearing is a complex function that has both cognitive and emotional aspects. A person with hearing loss may have consequences in the physical, mental and social domains. Hearing loss in the context of clinical audiology is currently defined based on type of pathology and severity. However, evidence from both clinical findings and research suggest that this may not cover all the aspects of ‘hearing loss’ as a disability. Conclusion: Defining and describing hearing loss and its consequences with a holistic approach has some clinical value particularly in the context of audiological enablement/rehabilitation.
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| 4. |
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| 5. |
- C. Manchaiah, Vinaya K., 1983-, et al.
(författare)
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The role of communication partners in the audiological enablement/rehabilitation of a person with hearing impairment : An overview
- 2012
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Ingår i: Audiological Medicine. - 1651-386X .- 1651-3835. ; 10:1, s. 21-30
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Tidskriftsartikel (refereegranskat)abstract
- Objective: Hearing impairment is known to have various effects upon both the person with hearing impairment (PHI) and their communication partners (CPs). In addition, CPs are reported to play an important role in making the decision to seek a consultation and the acceptance of intervention by the PHI. The overall aim of this paper is to provide a comprehensive overview of the role of the CP in the audiological enablement/rehabilitation of the PHI keeping clinical practice in focus. Method: A literature review was conducted using a number of resources including electronic databases, books and websites. Results: An overview of the literature was presented in the following sections: 1) Factors influencing the audiological enablement/rehabilitation of the PHI; 2) Effect of the PHI's hearing impairment on their CPs; 3) CPs’ influence on their PHI's audiological enablement/rehabilitation; 4) Positive experiences reported by CPs of the PHI; 5) Models to represent CPs within the social network context of the PHI; and 6) CP involvement in the audiological enablement/rehabilitation. This paper also identifies gaps in the literature and provides recommendations for further research. Conclusion: It is clear that involvement of the CP in the audiological enablement/rehabilitation can result in mutual advantages for both the PHI and their CPs.
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| 6. |
- Chundu, Srikanth, et al.
(författare)
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Parental reported benefits and shortcomings of cochlear implantation : Pilot study findings from Southeast Asia
- 2013
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Ingår i: Cochlear Implants International. - : Maney Publishing. - 1467-0100 .- 1754-7628. ; 14:1, s. 22-27
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Tidskriftsartikel (refereegranskat)abstract
- Objective The aim of the study was to understand the reported benefits and shortcomings by parents of children with cochlear implants and who contribute towards the cost of the implant. Method Thirty parents of children with cochlear implants from a hearing impaired school in Southeast Asia completed open-ended questionnaires and the data were analysed using content analysis. Results A wide range of benefits and shortcomings were reported. However, it is notable that the single most reported shortcoming was related to cost. Discussion The results suggest that, even though, in general, the reports about benefits and shortcomings were similar to previous results from western countries, the emphasis given to various aspects of shortcomings was different. In particular, it appears that parentally reported outcomes could be related to many factors including the hearing healthcare system with the costs involved for the implanted individuals and their families. These findings help us understand the parental perspectives of the success of cochlear implantation and will be useful during parental counselling sessions.
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| 7. |
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| 8. |
- Fransen, Erik, et al.
(författare)
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Occupational Noise, Smoking, and a High Body Mass Index are Risk Factors for Age-related Hearing Impairment and Moderate Alcohol Consumption is Protective : A European Population-based Multicenter Study
- 2008
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Ingår i: Journal of the Association for Research in Otolaryngology. - : Springer. - 1525-3961 .- 1438-7573. ; 9:3, s. 264-276
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Tidskriftsartikel (refereegranskat)abstract
- A multicenter study was set up to elucidate the environmental and medical risk factors contributing to age-related hearing impairment (ARHI). Nine subsamples, collected by nine audiological centers across Europe, added up to a total of 4,083 subjects between 53 and 67 years. Audiometric data (pure-tone average [PTA]) were collected and the participants filled out a questionnaire on environmental risk factors and medical history. People with a history of disease that could affect hearing were excluded. PTAs were adjusted for age and sex and tested for association with exposure to risk factors. Noise exposure was associated with a significant loss of hearing at high sound frequencies (>1 kHz). Smoking significantly increased high-frequency hearing loss, and the effect was dose-dependent. The effect of smoking remained significant when accounting for cardiovascular disease events. Taller people had better hearing on average with a more pronounced effect at low sound frequencies (<2 kHz). A high body mass index (BMI) correlated with hearing loss across the frequency range tested. Moderate alcohol consumption was inversely correlated with hearing loss. Significant associations were found in the high
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| 9. |
- Hendrickx, Jan-Jaap, et al.
(författare)
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Familial aggregation of pure tone hearing thresholds in an aging European population
- 2013
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Ingår i: Otology and Neurotology. - : Lippincott Williams & Wilkins. - 1531-7129 .- 1537-4505. ; 34:5, s. 838-844
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To investigate the familial correlations and intraclass correlation of age-related hearing impairment (ARHI) in specific frequencies. In addition, heritability estimates were calculated.STUDY DESIGN: Multicenter survey in 8 European centers.SUBJECTS: One hundred ninety-eight families consisting of 952 family members, screened by otologic examination and structured interviews. Subjects with general conditions, known to affect hearing thresholds or known otologic cause were excluded from the study.RESULTS: We detected familial correlation coefficients of 0.36, 0.37, 0.36, and 0.30 for 0.25, 0.5, 1, and 2 kHz, respectively, and correlation coefficients of 0.20 and 0.18 for 4 and 8 kHz, respectively. Variance components analyses showed that the proportion of the total variance attributable to family differences was between 0.32 and 0.40 for 0.25, 0.5, 1, and 2 kHz and below 0.20 for 4 and 8 kHz. When testing for homogeneity between sib pair types, we observed a larger familial correlation between female than male subjects. Heritability estimates ranged between 0.79 and 0.36 across the frequencies.DISCUSSION: Our results indicate that there is a substantial shared familial effect in ARHI. We found that familial aggregation of ARHI is markedly higher in the low frequencies and that there is a trend toward higher familial aggregation in female compared with male subjects.
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| 10. |
- Hendrickx, Jan-Jaap, et al.
(författare)
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Familial aggregation of tinnitus : a European multicentre study
- 2007
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Ingår i: B-ENT. - Louvain, Belgium : Societe Royale Belge d'Oto - Rhino - Laryngologie et de Chirurgie Cervico - Faciale. - 0001-6497. ; 3:Suppl 7, s. 51-60
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- INTRODUCTION AND AIM:Tinnitus is a common condition affecting approximately 20% of the older population. There is increasing evidence that changes in the central auditory system following cochlear malfunctioning are responsible for tinnitus. To date, few investigators have studied the influence of genetic factors on tinnitus. The present report investigates the presence of a familial effect in tinnitus subjects.METHODS:In a European multicentre study, 198 families were recruited in seven European countries. Each family had at least 3 siblings. Subjects were screened for causes of hearing loss other than presbyacusis by clinical examination and a questionnaire. The presence of tinnitus was evaluated with the question "Nowadays, do you ever get noises in your head or ear (tinnitus) which usually last longer than five minutes". Familial aggregation was tested using three methods: a mixed model approach, calculating familial correlations, and estimating the risk of a subject having tinnitus if the disorder is present in another family member.RESULTS:All methods demonstrated a significant familial effect for tinnitus. The effect persisted after correction for the effect of other risk factors such as hearing loss, gender and age. The size of the familial effect is smaller than that for age-related hearing impairment, with a familial correlation of 0.15.CONCLUSION:The presence of a familial effect for tinnitus opens the door to specific studies that can determine whether this effect is due to a shared familial environment or the involvement of genetic factors. Subsequent association studies may result in the identification of the factors responsible. In addition, more emphasis should be placed on the effect of role models in the treatment of tinnitus.
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| 11. |
- Huyghe, Jeroen R., et al.
(författare)
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Genome-wide SNP-based linkage scan identifies a locus on 8q24 for an age-related hearing impairment trait
- 2008
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Ingår i: American Journal of Human Genetics. - : Cell Press. - 0002-9297 .- 1537-6605. ; 83:3, s. 401-407
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Tidskriftsartikel (refereegranskat)abstract
- Age-related hearing impairment (ARHI), or presbycusis, is a very common multifactorial disorder. Despite the knowledge that genetics play an important role in the etiology of human ARHI as revealed by heritability studies, to date, its precise genetic determinants remain elusive. Here we report the results of a cross-sectional family-based genetic study employing audiometric data. By using principal component analysis, we were able to reduce the dimensionality of this multivariate phenotype while capturing most of the variation and retaining biologically important features of the audiograms. We conducted a genome-wide association as well as a linkage scan with high-density SNP microarrays. Because of the presence of genetic population substructure, association testing was stratified after which evidence was combined by meta-analysis. No association signals reaching genome-wide significance were detected. Linkage analysis identified a linkage peak on 8q24.13-q24.22 for a trait correlated to audiogram shape. The signal reached genome-wide significance, as assessed by simulations. This finding represents the first locus for an ARHI trait.
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| 12. |
- Manchaiah, Vinaya K. C., 1983-, et al.
(författare)
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Communication partners’ journey through their partner’s hearing impairment
- 2013
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Ingår i: International Journal of Otolaryngology. - : Hindawi Publishing Corporation. - 1687-9201 .- 1687-921X. ; 2013:707910, s. 1-11
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Tidskriftsartikel (refereegranskat)abstract
- The objective of the study was to further the Ida Institute model on communication partner’s (CPs) journey through experiences of person with hearing impairment (PHI), based on the perspectives of CPs. Qualitative approach using thematic analysis and process mapping. Nine CPs of hearing aid users participated in the study, recruited through the Swansea hearing impaired support group. Semi-structured interviews were conducted and the data were used to develop a CP journey template. The Ida Institute model (based on professionals’ perspective) was compared with the new template developed (based on CPs perspectives). Seven main phases were identified which include: (1) contemplation; (2) awareness; (3) persuasion; (4) validation; (5) rehabilitation; (6) adaptation; and (7) resolution. The results suggest some commonalities and differences between the views of professionals and CPs. A new phase ‘adaptation’ was identified from CPs’ reported experiences, which was not identified by professionals in the Ida Institute model. The CP journey model could be a useful tool during audiological enablement/rehabilitation sessions to promote discussion between the PHI and the CP. In addition, it can be used in the training of hearing healthcare professionals.
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| 13. |
- Manchaiah, Vinaya K. C., 1983-, et al.
(författare)
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The patient journey of adults with hearing impairment: the patients’ views
- 2011
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Ingår i: Clinical Otolaryngology. - : Wiley. - 1749-4478 .- 1365-2273. ; 36:3, s. 227-234
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Tidskriftsartikel (refereegranskat)abstract
- Objective: The term ‘patient journey’ refers to the experiences and processes the patient goes through during the course of a disease and its treatment. The study explores the perspectives of adults with acquired hearing impairment and to further develop the patient journey template based on the Ida model. Design: Qualitative approach using thematic analysis and process mapping. Setting: Support groups of people with hearing impairment. Participants: Thirty-two adults with acquired hearing impairment from two hearing impaired groups in Wales. All were hearing aid users. Main outcome measure: Participants worked in small groups to describe their experiences through hearing loss. These data were used to develop a template of the patients’ perspective of the journey. This was then compared with the perspective of professionals, and a ‘patient journey template for adults with acquired hearing impairment’ was developed. Results: This template identifies seven main phases as follows: (i) pre-awareness; (ii) awareness; (iii) movement; (iv) diagnostics; (v) rehabilitation; (vi) self-evaluation; and (vii) resolution. The study identified a number of new components. The self-evaluation component was not defined by professionals and reflects the need for patients to consider the costs, benefits and alternatives to the approach provided by audiologists. It is important for audiologists to be aware of this. Conclusion: The study highlighted the differences and commonalities in perspectives of professionals and patients. Use of the patient journey can help clinicians to understand the unique experiences their patients go through help them to develop patient-centred treatment.
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| 14. |
- Manchaiah, Vinaya K. C., et al.
(författare)
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The patient journey of adults with sudden-onset acquired hearing impairment : a pilot study
- 2012
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Ingår i: Journal of Laryngology and Otology. - : Cambridge University Press (CUP). - 0022-2151 .- 1748-5460. ; 126:5, s. 475-481
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Tidskriftsartikel (refereegranskat)abstract
- Objective: A previous study examined the patient journey of adults with gradual-onset acquired hearing impairment. This study examined the same for adults with sudden-onset acquired hearing impairment, and assessed differences. less thanbrgreater than less thanbrgreater thanStudy design: Data were collected from 16 audiologists, using the Ida Institute template, and from four adults with sudden-onset acquired hearing impairment, through semi-structured interviews. Data were analysed using thematic analysis and presented using a process mapping model. less thanbrgreater than less thanbrgreater thanResults: A patient journey template for sudden-onset acquired hearing impairment was developed based on the professionals and patients perspectives. The main difference between these two groups perspectives was seen in the self-evaluation phase: some stages within this phase were recognised by the patients but not by the professionals. The main difference between the current and the previous study was the absence of a pre-awareness phase in the journey described by patients with sudden-onset acquired hearing impairment, compared with that described by patients with gradual-onset acquired hearing impairment. less thanbrgreater than less thanbrgreater thanConclusion: Patient journey templates could be useful counselling tools for ear and hearing healthcare specialists. However, such templates should be used only as a baseline; it is important to take a detailed case history to understand each patients unique experience, including the psychosocial impact of hearing impairment.
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| 15. |
- Manchaiah, Vinaya K. C., 1983-, et al.
(författare)
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Use of the ‘patient journey’ model in the internet-based pre-fitting counseling of a person with hearing disability : study protocol for a randomized controlled trial
- 2013
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Ingår i: Trials. - : BioMed Central. - 1745-6215. ; 14:25
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundHearing impairment is one of the most frequent chronic conditions. Persons with a hearing impairment (PHI) have various experiences during their ‘journey’ through hearing loss. In our previous studies we have developed a ‘patient journey’ model of PHI and their communication partners (CPs). We suggest this model could be useful in internet-based pre-fitting counseling of a person with hearing disability (PHD).Methods/DesignA randomized controlled trial (RCT) with waiting list control (WLC) design will be used in this study. One hundred and fifty eight participants with self-reported hearing disability (that is, score >20 in the Hearing Handicap Questionnaire (HHQ)) will be recruited to participate in this study. They will be assigned to one of two groups (79 participants in each group): (1) Information and counseling provision using the ‘patient journey’ model; and (2) WLC. They will participate in a 30 day (4 weeks) internet-based counseling program based on the ‘patient journey’ model. Various outcome measures which focuses on hearing disability, depression and anxiety, readiness to change and acceptance of hearing disability will be administered pre (one week before) and post (one week and six months after) intervention to evaluate the effectiveness of counseling.DiscussionInternet-based counseling is being introduced as a viable option for audiological rehabilitation. We predict that the ‘patient journey’ model will have several advantages during counseling of a PHD. Such a program, if proven effective, could yield cost and time-efficient ways of managing hearing disability.
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| 16. |
- Stephens, Dafydd, et al.
(författare)
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Reported benefits and shortcomings of cochlear implantation by patients and their significant others.
- 2008
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Ingår i: Cochlear implants international. - 1467-0100. ; 9:4, s. 186-98
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Tidskriftsartikel (refereegranskat)abstract
- Ninety four consecutive adults who had been fitted with cochlear implants for at least six months were sent open-ended questionnaires asking them to list the benefits and shortcomings they experienced as a result of their implants. Partners of the patients were asked to complete similar questionnaires. A wide range of benefits was reported, predominantly acoustical and psychosocial. Most of the shortcomings were acoustical and practical. Significant others reported fewer benefits and fewer shortcomings than the patients. However, the overall pattern of responses was similar. More acoustical and psychosocial benefits were reported by those fitted with cochlear implants than by those with hearing aids or bone-anchored hearing aids.
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| 17. |
- Van Eyken, Els, et al.
(författare)
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Contribution of the N-acetyltransferase 2 polymorphism NAT2*6A to age-related hearing impairment
- 2007
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Ingår i: Journal of Medical Genetics. - : B M J Group. - 0022-2593 .- 1468-6244. ; 44:9, s. 570-578
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundAge‐related hearing impairment (ARHI) is the most common sensory impairment in older people, affecting 50% of those aged 80 years. The proportion of older people is increasing in the general population, and as a consequence, the number of people affected with ARHI is growing. ARHI is a complex disorder, with both environmental and genetic factors contributing to the disease. The first studies to elucidate these genetic factors were recently performed, resulting in the identification of the first two susceptibility genes for ARHI, NAT2 and KCNQ4.MethodsIn the present study, the association between ARHI and polymorphisms in genes that contribute to the defence against reactive oxygen species, including GSTT1, GSTM1 and NAT2, was tested. Samples originated from seven different countries and were combined into two test population samples, the general European population and the Finnish population. Two distinct phenotypes for ARHI were studied, Zlow and Zhigh, representing hearing in the low and high frequencies, respectively. Statistical analysis was performed for single polymorphisms (GSTM1, GSTT1, NAT2*5A, NAT2*6A, and NAT2*7A), haplotypes, and gene–environment and gene–gene interactions.ResultsWe found an association between ARHI and GSTT1 and GSTM1 in the Finnish population sample, and with NAT2*6A in the general European population sample. The latter finding replicates previously published data.ConclusionAs replication is considered the ultimate proof of true associations in the study of complex disorders, this study provides further support for the involvement of NAT2*6A in ARHI.
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| 18. |
- Van Eyken, Els, et al.
(författare)
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The Contribution of GJB2 (Connexin 26) 35delG to Age-Related Hearing Impairment and Noise-Induced Hearing Loss
- 2007
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Ingår i: Otology and Neurotology. - : Lippincott Williams & Wilkins. - 1531-7129 .- 1537-4505. ; 28:7, s. 970-975
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Tidskriftsartikel (refereegranskat)abstract
- Hypothesis: The common GJB2 (Connexin 26) 35delG mutation might contribute to the development of age-related hearing impairment (ARHI) and noise-induced hearing loss (NIHL).Background: GJB2, a gene encoding a gap junction protein expressed in the inner ear, has been suggested to be involved in the potassium recycling pathway in the cochlea. GJB2 mutations account for a large number of individuals with nonsyndromic recessive hearing loss, with 35delG being the most frequent mutation in populations of European origin. Other genes involved in potassium homeostasis have been suggested to be associated with ARHI and NIHL, and distortion product otoacoustic emission distortions indicative of hearing loss alterations have been found in 35delG carriers.Method: We genotyped 35delG in two distinct sample sets: an ARHI sample set, composed of 2,311 Caucasian samples from nine different centers originating from seven different countries with an age range between 53 and 67 years, and an NIHL sample set consisting of 702 samples from the two extremes of a noise-exposed Polish sample.Results: After statistical analysis, we were unable to detect an association between 35delG and ARHI, nor between 35delG and NIHL.Conclusion: Our findings indicate that there is no increased susceptibility in 35delG carriers for the development of ARHI or NIHL.
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| 19. |
- Van Laer, Lut, et al.
(författare)
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The grainyhead like 2 gene (GRHL2), alias TFCP2L3, is associated with age-related hearing impairment
- 2008
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Ingår i: Human Molecular Genetics. - : Oxford University Press. - 0964-6906 .- 1460-2083. ; 17:2, s. 159-169
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Tidskriftsartikel (refereegranskat)abstract
- Age-related hearing impairment (ARHI) is the most prevalent sensory impairment in the elderly. ARHI is a complex disease caused by an interaction between environmental and genetic factors. The contribution of various environmental factors has been relatively extensively studied. In contrast, investigations to identify the genetic risk factors have only recently been initiated. In this paper we describe the results of an association study performed on 2418 ARHI samples derived from nine centers from seven European countries. In 70 candidate genes, a total of 768 tag single nucleotide polymorphisms (SNPs) were selected based on HAPMAP data. These genes were chosen among the monogenic hearing loss genes identified in mice and men in addition to several strong functional candidates. After genotyping and data polishing, statistical analysis of all samples combined resulted in a P-value that survived correction for multiple testing for one SNP in the GRHL2 gene. Other SNPs in this gene were also associated, albeit to a lesser degree. Subsequently, an analysis of the most significant GRHL2 SNP was performed separately for each center. The direction of the association was identical in all nine centers. Two centers showed significant associations and a third center showed a trend towards significance. Subsequent fine mapping of this locus demonstrated that the majority of the associated SNPs reside in intron 1. We hypothesize that the causative variant may change the expression levels of a GRHL2 isoform.
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