| 1. |
- Joffrin, E., et al.
(författare)
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Overview of the JET preparation for deuterium-tritium operation with the ITER like-wall
- 2019
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 59:11
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Forskningsöversikt (refereegranskat)abstract
- For the past several years, the JET scientific programme (Pamela et al 2007 Fusion Eng. Des. 82 590) has been engaged in a multi-campaign effort, including experiments in D, H and T, leading up to 2020 and the first experiments with 50%/50% D-T mixtures since 1997 and the first ever D-T plasmas with the ITER mix of plasma-facing component materials. For this purpose, a concerted physics and technology programme was launched with a view to prepare the D-T campaign (DTE2). This paper addresses the key elements developed by the JET programme directly contributing to the D-T preparation. This intense preparation includes the review of the physics basis for the D-T operational scenarios, including the fusion power predictions through first principle and integrated modelling, and the impact of isotopes in the operation and physics of D-T plasmas (thermal and particle transport, high confinement mode (H-mode) access, Be and W erosion, fuel recovery, etc). This effort also requires improving several aspects of plasma operation for DTE2, such as real time control schemes, heat load control, disruption avoidance and a mitigation system (including the installation of a new shattered pellet injector), novel ion cyclotron resonance heating schemes (such as the three-ions scheme), new diagnostics (neutron camera and spectrometer, active Alfven eigenmode antennas, neutral gauges, radiation hard imaging systems...) and the calibration of the JET neutron diagnostics at 14 MeV for accurate fusion power measurement. The active preparation of JET for the 2020 D-T campaign provides an incomparable source of information and a basis for the future D-T operation of ITER, and it is also foreseen that a large number of key physics issues will be addressed in support of burning plasmas.
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| 5. |
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- 2019
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Tidskriftsartikel (refereegranskat)
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| 6. |
- Forouzanfar, Mohammad H, et al.
(författare)
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Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013 : a systematic analysis for the Global Burden of Disease Study 2013.
- 2015
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Ingår i: The Lancet. - 0140-6736 .- 1474-547X. ; 386:10010, s. 2287-2323
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The Global Burden of Disease, Injuries, and Risk Factor study 2013 (GBD 2013) is the first of a series of annual updates of the GBD. Risk factor quantification, particularly of modifiable risk factors, can help to identify emerging threats to population health and opportunities for prevention. The GBD 2013 provides a timely opportunity to update the comparative risk assessment with new data for exposure, relative risks, and evidence on the appropriate counterfactual risk distribution.METHODS: Attributable deaths, years of life lost, years lived with disability, and disability-adjusted life-years (DALYs) have been estimated for 79 risks or clusters of risks using the GBD 2010 methods. Risk-outcome pairs meeting explicit evidence criteria were assessed for 188 countries for the period 1990-2013 by age and sex using three inputs: risk exposure, relative risks, and the theoretical minimum risk exposure level (TMREL). Risks are organised into a hierarchy with blocks of behavioural, environmental and occupational, and metabolic risks at the first level of the hierarchy. The next level in the hierarchy includes nine clusters of related risks and two individual risks, with more detail provided at levels 3 and 4 of the hierarchy. Compared with GBD 2010, six new risk factors have been added: handwashing practices, occupational exposure to trichloroethylene, childhood wasting, childhood stunting, unsafe sex, and low glomerular filtration rate. For most risks, data for exposure were synthesised with a Bayesian meta-regression method, DisMod-MR 2.0, or spatial-temporal Gaussian process regression. Relative risks were based on meta-regressions of published cohort and intervention studies. Attributable burden for clusters of risks and all risks combined took into account evidence on the mediation of some risks such as high body-mass index (BMI) through other risks such as high systolic blood pressure and high cholesterol.FINDINGS: All risks combined account for 57·2% (95% uncertainty interval [UI] 55·8-58·5) of deaths and 41·6% (40·1-43·0) of DALYs. Risks quantified account for 87·9% (86·5-89·3) of cardiovascular disease DALYs, ranging to a low of 0% for neonatal disorders and neglected tropical diseases and malaria. In terms of global DALYs in 2013, six risks or clusters of risks each caused more than 5% of DALYs: dietary risks accounting for 11·3 million deaths and 241·4 million DALYs, high systolic blood pressure for 10·4 million deaths and 208·1 million DALYs, child and maternal malnutrition for 1·7 million deaths and 176·9 million DALYs, tobacco smoke for 6·1 million deaths and 143·5 million DALYs, air pollution for 5·5 million deaths and 141·5 million DALYs, and high BMI for 4·4 million deaths and 134·0 million DALYs. Risk factor patterns vary across regions and countries and with time. In sub-Saharan Africa, the leading risk factors are child and maternal malnutrition, unsafe sex, and unsafe water, sanitation, and handwashing. In women, in nearly all countries in the Americas, north Africa, and the Middle East, and in many other high-income countries, high BMI is the leading risk factor, with high systolic blood pressure as the leading risk in most of Central and Eastern Europe and south and east Asia. For men, high systolic blood pressure or tobacco use are the leading risks in nearly all high-income countries, in north Africa and the Middle East, Europe, and Asia. For men and women, unsafe sex is the leading risk in a corridor from Kenya to South Africa.INTERPRETATION: Behavioural, environmental and occupational, and metabolic risks can explain half of global mortality and more than one-third of global DALYs providing many opportunities for prevention. Of the larger risks, the attributable burden of high BMI has increased in the past 23 years. In view of the prominence of behavioural risk factors, behavioural and social science research on interventions for these risks should be strengthened. Many prevention and primary care policy options are available now to act on key risks.FUNDING: Bill & Melinda Gates Foundation.
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| 7. |
- Berndt, Sonja I., et al.
(författare)
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Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
- 2013
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 45:5, s. 501-U69
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Tidskriftsartikel (refereegranskat)abstract
- Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups.
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| 8. |
- Speliotes, Elizabeth K., et al.
(författare)
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Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
- 2010
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:11, s. 937-948
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Tidskriftsartikel (refereegranskat)abstract
- Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ~2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 × 10−8), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.
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| 9. |
- Towner, Jamie, et al.
(författare)
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Assessing the performance of global hydrological models for capturing peak river flows in the Amazon basin
- 2019
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Ingår i: Hydrology and Earth System Sciences. - : COPERNICUS GESELLSCHAFT MBH. - 1027-5606 .- 1607-7938. ; 23:7, s. 3057-3080
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Tidskriftsartikel (refereegranskat)abstract
- Extreme flooding impacts millions of people that live within the Amazon floodplain. Global hydrological models (GHMs) are frequently used to assess and inform the management of flood risk, but knowledge on the skill of available models is required to inform their use and development. This paper presents an intercomparison of eight different GHMs freely available from collaborators of the Global Flood Partnership (GFP) for simulating floods in the Amazon basin. To gain insight into the strengths and shortcomings of each model, we assess their ability to reproduce daily and annual peak river flows against gauged observations at 75 hydrological stations over a 19-year period (1997-2015). As well as highlighting regional variability in the accuracy of simulated streamflow, these results indicate that (a) the meteorological input is the dominant control on the accuracy of both daily and annual maximum river flows, and (b) ground-water and routing calibration of Lisflood based on daily river flows has no impact on the ability to simulate flood peaks for the chosen river basin. These findings have important relevance for applications of large-scale hydrological models, including analysis of the impact of climate variability, assessment of the influence of long-term changes such as land-use and anthropogenic climate change, the assessment of flood likelihood, and for flood forecasting systems.
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| 10. |
- Wanzala, Maureen A., et al.
(författare)
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Assessment of global reanalysis precipitation for hydrological modelling in data-scarce regions : A case study of Kenya
- 2022
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Ingår i: Journal of Hydrology. - : Elsevier. - 2214-5818. ; 41
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Tidskriftsartikel (refereegranskat)abstract
- Study region: 19 flood prone catchments in Kenya, Eastern Africa.Study focus: Flooding is a major natural hazard especially in developing countries, and the need for timely, reliable, and actionable hydrological forecasts is paramount. Hydrological modelling is essential to produce forecasts but is a challenging task, especially in poorly gauged catchments, because of the inadequate temporal and spatial coverage of hydro-meteorological observations. Open access global meteorological reanalysis datasets can fill in this gap, however they have significant errors. This study assesses the performance of four reanalysis datasets (ERA5, ERA Interim, CFSR and JRA55) over Kenya for the period 1981-2016 on daily, monthly, seasonal, and annual timescales. We firstly evaluate the reanalysis datasets by comparing them against observations from the Climate Hazards group Infrared Precipitation with Station. Secondly, we evaluate the ability of these reanalysis datasets to simulate streamflow using GR4J model considering both model performance and parameters sensitivity and identifiability.New hydrological insights for the region: While ERA5 is the best performing dataset overall, performance varies by season, and catchment and therefore there are marked differences in the suitability of reanalysis products for forcing hydrological models. Overall, wetland catchments in the western regions and highlands of Kenya obtained relatively better scores compared to those in the semi-arid regions, this can inform future applications of reanalysis products for setting up hydrological models that can be used for flood forecasting, early warning, and early action in data scarce regions, such as Kenya.
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| 11. |
- Emerton, Rebecca, et al.
(författare)
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Developing a global operational seasonal hydro-meteorological forecasting system : G1oFAS-Seasonal v1.0
- 2018
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Ingår i: Geoscientific Model Development. - : COPERNICUS GESELLSCHAFT MBH. - 1991-959X .- 1991-9603. ; 11:8, s. 3327-3346
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Tidskriftsartikel (refereegranskat)abstract
- Global overviews of upcoming flood and drought events are key for many applications, including disaster risk reduction initiatives. Seasonal forecasts are designed to provide early indications of such events weeks or even months in advance, but seasonal forecasts for hydrological variables at large or global scales are few and far between. Here, we present the first operational global-scale seasonal hydrometeorological forecasting system: G1oFAS-Seasonal. Developed as an extension of the Global Flood Awareness System (G1oFAS), G1oFAS-Seasonal couples seasonal meteorological forecasts from ECMWF with a hydrological model to provide openly available probabilistic forecasts of river flow out to 4 months ahead for the global river network. This system has potential benefits not only for disaster risk reduction through early awareness of floods and droughts, but also for water-related sectors such as agriculture and water resources management, in particular for regions where no other forecasting system exists. We describe the key hydrometeorological components and computational framework of G1oFAS-Seasonal, alongside the forecast products available, before discussing initial evaluation results and next steps.
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| 12. |
- Emerton, Rebecca E., et al.
(författare)
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What is the most useful approach for forecasting hydrological extremes during El Niño?
- 2019
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Ingår i: Environmental Research Communications (ERC). - : IOP PUBLISHING LTD. - 2515-7620. ; 1:3
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Tidskriftsartikel (refereegranskat)abstract
- In the past, efforts to prepare for the impacts of El Nino-driven flood and drought hazards have often relied on seasonal precipitation forecasts as a proxy for hydrological extremes, due to a lack of hydrologically relevant information. However, precipitation forecasts are not the best indicator of hydrological extremes. Now, two different global scale hydro-meteorological approaches for predicting river flow extremes are available to support flood and drought preparedness. These approaches are statistical forecasts based on large-scale climate variability and teleconnections, and resource-intensive dynamical forecasts using coupled ocean-atmosphere general circulation models. Both have the potential to provide early warning information, and both are used to prepare for El Nino impacts, but which approach provides the most useful forecasts? This study uses river flow observations to assess and compare the ability of two recently-developed forecasts to predict high and low river flow during El Nino: statistical historical probabilities of ENSO-driven hydrological extremes, and the dynamical seasonal river flow outlook of the Global Flood Awareness System (GloFAS-seasonal). Our findings highlight regions of the globe where each forecast is (or is not) skilful compared to a forecast of climatology, and the advantages and disadvantages of each forecasting approach. We conclude that in regions where extreme river flow is predominantly driven by El Nino, or in regions where GloFAS-seasonal currently lacks skill, the historical probabilities generally provide a more useful forecast. In areas where other teleconnections also impact river flow, with the effect of strengthening, mitigating or even reversing the influence of El Nino, GloFAS-seasonal forecasts are typically more useful.
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| 13. |
- Franke, James A, et al.
(författare)
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Agricultural breadbaskets shift poleward given adaptive farmer behavior under climate change
- 2022
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Ingår i: Global Change Biology. - : Wiley. - 1354-1013 .- 1365-2486. ; 28:1, s. 167-181
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Tidskriftsartikel (refereegranskat)abstract
- Modern food production is spatially concentrated in global "breadbaskets". A major unresolved question is whether these peak production regions will shift poleward as the climate warms, allowing some recovery of potential climaterelated losses. While agricultural impacts studies to date have focused on currently cultivated land, the Global Gridded Crop Model Intercomparison Project (GGCMI) Phase 2 experiment allows us to assess changes in both yields and the location of peak productivity regions under warming. We examine crop responses under projected end-of-century warming using 7 process-based models simulating 5 major crops (maize, rice, soybeans, and spring and winter wheat) with a variety of adaptation strategies. We find that in no-adaptation cases, when planting date and cultivar choices are held fixed, regions of peak production remain stationary and yield losses can be severe, since growing seasons contract strongly with warming. When adaptations in management practices are allowed (cultivars that retain growing season length under warming and modified planting dates), peak productivity zones shift poleward and yield losses are largely recovered. While most growing-zone shifts are ultimately limited by geography, breadbaskets studied here move poleward over 600 km on average by end of the century under RCP8.5. These results suggest that agricultural impacts assessments can be strongly biased if restricted in spatial area or in the scope of adaptive behavior considered. Accurate evaluation of food security under climate change requires global modeling and careful treatment of adaptation strategies.
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| 14. |
- Towner, Jamie, et al.
(författare)
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Attribution of Amazon floods to modes of climate variability : A review
- 2020
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Ingår i: Meteorological Applications. - : WILEY. - 1350-4827 .- 1469-8080. ; 27:5
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Forskningsöversikt (refereegranskat)abstract
- Anomalous conditions in the oceans and atmosphere have the potential to be used to enhance the predictability of flood events, enabling earlier warnings to reduce risk. In the Amazon basin, extreme flooding is consistently attributed to warmer or cooler conditions in the tropical Pacific and Atlantic oceans, with some evidence linking floods to other hydroclimatic drivers such as the Madden-Julian Oscillation (MJO). This review evaluates the impact of several hydroclimatic drivers on rainfall and river discharge regimes independently, aggregating all the information of previous studies to provide an up-to-date depiction of what we currently know and do not know about how variations in climate impact flooding in the Amazon. Additionally, 34 major flood events that have occurred since 1950 in the Amazon and their attribution to climate anomalies are documented and evaluated. This review finds that despite common agreement within the literature describing the relationship between phases of climate indices and hydrometeorological variables, results linking climate anomalies and flood hazard are often limited to correlation rather than to causation, while the understanding of their usefulness for flood forecasting is weak. There is a need to understand better the ocean-atmosphere response mechanisms that led to previous flood events. In particular, examining the oceanic and atmospheric conditions preceding individual hydrological extremes, as opposed to composite analysis, could provide insightful information into the magnitude and spatial distribution of anomalous sea surface temperatures required to produce extreme floods. Importantly, such an analysis could provide meaningful thresholds on which to base seasonal flood forecasts.
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| 15. |
- Towner, Jamie, et al.
(författare)
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Influence of ENSO and tropical Atlantic climate variability on flood characteristics in the Amazon basin
- 2021
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Ingår i: Hydrology and Earth System Sciences. - : Copernicus Publications. - 1027-5606 .- 1607-7938. ; 25:7, s. 3875-3895
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Tidskriftsartikel (refereegranskat)abstract
- Flooding in the Amazon basin is frequently attributed to modes of large-scale climate variability, but little attention is paid to how these modes influence the timing and duration of floods despite their importance to early warning systems and the significant impacts that these flood characteristics can have on communities. In this study, river discharge data from the Global Flood Awareness System (Glo-FAS 2.1) and observed data at 58 gauging stations are used to examine whether positive or negative phases of several Pacific and Atlantic indices significantly alter the characteristics of river flows throughout the Amazon basin (19792015). Results show significant changes in both flood magnitude and duration, particularly in the north-eastern Amazon for negative El Nino-Southern Oscillation (ENSO) phases when the sea surface temperature (SST) anomaly is positioned in the central tropical Pacific. This response is not identified for the eastern Pacific index, highlighting how the response can differ between ENSO types. Although flood magnitude and duration were found to be highly correlated, the impacts of large-scale climate variability on these characteristics are non-linear; some increases in annual flood maxima coincide with decreases in flood duration. The impact of flood timing, however, does not follow any notable pattern for all indices analysed. Finally, observed and simulated changes are found to be much more highly correlated for negative ENSO phases compared to the positive phase, meaning that GloFAS struggles to accurately simulate the differences in flood characteristics between El Nino and neutral years. These results have important implications for both the social and physical sectors working towards the improvement of early warning action systems for floods.
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