| 1. |
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| 2. |
- Barreto Henriksson, Helena, et al.
(författare)
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Determination of mechanical and rheological properties of a cell-loaded peptide gel during ECM production
- 2019
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Ingår i: International Journal of Pharmaceutics. - : Elsevier BV. - 0378-5173 .- 1873-3476. ; 563, s. 437-444
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Tidskriftsartikel (refereegranskat)abstract
- The development of an injectable biomaterial that supports cell survival and maintains or promotes nucleus pulposus (NP) phenotype could aid delivery of cells to degenerated NPs causing low back pain. Mesenchymal cells were loaded and grown in a synthetic peptide gel, PuraMatrix (R). Cells were observed within the gels over 0-28 days, and accumulation of glycosaminoglycans were detected by histological staining. The mechanical properties of the cell-loaded constructs, and the change of the mechanical properties were studied using stress relaxation of the gels under compression and confinement. The PuraMatrix (R) gel was shown to relax fast on compression indicating that the fluid could easily flow out of the gel, and thus indicating the presence of large pores/voids. The presence of these pores/voids was further supported by high mobility of dextran molecules, determined using fluorescence recovery after photo bleaching. The stress required to deform the cell-loaded constructs to a specific strain increases at day 21, at which point the presence of glycosaminoglycans within the cell-loaded constructs was also observed. The results provide evidence of changes in mechanical properties of the PuraMatrix (R) matrix upon excretion of the extracellular matrix by the cells.
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| 3. |
- Backman, Helena, et al.
(författare)
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Lung function trajectories and associated mortality among adults with and without airway obstruction
- 2023
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Ingår i: American Journal of Respiratory and Critical Care Medicine. - : American Thoracic Society. - 1073-449X .- 1535-4970. ; 208:10, s. 1063-1074
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Tidskriftsartikel (refereegranskat)abstract
- Rationale: Spirometry is essential for diagnosis and assessment of prognosis in COPD.Objectives: To identify FEV1 trajectories and their determinants, based on annual spirometry measurements among individuals with and without airway obstruction. Furthermore, to assess mortality in relation to trajectories.Methods: In 2002-04, individuals with airway obstruction (AO) (FEV1/VC<0.70, n=993) and age- and sex-matched non-obstructive (NO) referents were recruited from population-based cohorts. Annual spirometries until 2014 were utilized in joint-survival Latent Class Mixed Models to identify lung function trajectories. Mortality data were collected during 15 years of follow-up.Results: Three trajectories were identified among the AO-cases and two among the NO referents. Trajectory membership was driven by baseline FEV1%predicted (%pred) in both groups and additionaly, pack-years in AO and current smoking in NO. Longitudinal FEV1%pred level depended on baseline FEV1%pred, pack-years and obesity. The trajectories were distributed: 79.6% T1AO FEV1-high with normal decline, 12.8% T2AO FEV1-high with rapid decline, and 7.7% T3AO FEV1-low with normal decline (mean 27, 72 and 26 mL/year) among AO-individuals, and 96.7% T1NO FEV1-high with normal decline and 3.3% T2NO FEV1-high with rapid decline (mean 34 and 173 mL/year) among referents. Hazard for death was increased for T2AO (HR1.56) and T3AO (HR3.45) vs. T1AO, and for T2NO (HR2.99) vs. T1NO.Conclusions: Three different FEV1 trajectories were identified among those with airway obstruction and two among the referents, with different outcomes in terms of FEV1-decline and mortality. The FEV1 trajectories among airway obstructive and the relationship between low FVC and trajectory outcome are of particular clinical interest.
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| 4. |
- Borgström, F, et al.
(författare)
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The cost-effectiveness of risedronate in the UK for the management of osteoporosis using the FRAX(R).
- 2009
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Ingår i: Osteoporosis International. - : Springer Science and Business Media LLC. - 0937-941X .- 1433-2965.
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Tidskriftsartikel (refereegranskat)abstract
- The study estimated the cost-effectiveness of risedronate compared to no treatment in UK women using the FRAX algorithm for fracture risk assessment. A Markov cohort model was used to estimate the cost-effectiveness. Risedronate was found cost-effective from the age of 65 years, assuming a willingness to pay for a QALY of pound30,000. INTRODUCTION: The aim of this study was to assess the cost-effectiveness of risedronate for the prevention and treatment in a UK setting using the FRAX(R) algorithm for fracture risk assessment. A further aim was to establish intervention thresholds with risedronate treatment. METHODS: The cost-effectiveness of risedronate was compared to no treatment in post-menopausal women with clinical risk factors for fracture using a Markov cohort model populated with data relevant for the UK. The model incorporated the features of FRAX(R) (the WHO risk assessment tool). The analysis had a health care perspective and quality adjusted life years was used as the main outcome measure. RESULTS: Treatment was cost-effective from the age of 65 years, assuming a willingness to pay for a QALY of pound30,000. Treatment was also cost-effective at all ages in women who had previously sustained a fragility fracture or in women with a parental history of hip fracture with a bone mineral density set at the threshold of osteoporosis. At the pound30,000 threshold value for a QALY, risedronate was on average found to cost-effective below the 10-year probability of a major osteoporotic fractures of 13.0%. CONCLUSIONS: Risedronate is a cost-effective agent for the treatment of established osteoporosis (osteoporosis and a prior fragility fracture) in women from the age of 50 years and older and above 65 years in women with osteoporosis alone. The results support the treatment recommendations in recent UK guidelines for osteoporosis.
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| 5. |
- Borgström, F, et al.
(författare)
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The cost-effectiveness of strontium ranelate in the UK for the management of osteoporosis.
- 2010
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Ingår i: Osteoporosis International. - : Springer Science and Business Media LLC. - 0937-941X .- 1433-2965. ; 21:2, s. 339-49
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Tidskriftsartikel (refereegranskat)abstract
- The cost-effectiveness of strontium ranelate was compared to no treatment in UK women using the FRAX algorithm for fracture risk assessment. At a willingness-to-pay of pound 30,000 per quality-adjusted life-year (QALY), strontium ranelate was generally cost-effective in women with prior fracture at the threshold of osteoporosis from an age of 65 years. INTRODUCTION: The objectives of the study were to estimate the cost-effectiveness of strontium ranelate in the UK for the treatment of osteoporosis and to establish intervention thresholds for treatment using the FRAX tool. METHODS: The cost-effectiveness of strontium ranelate was compared to no treatment in postmenopausal women with clinical risk factors for fracture using a lifetime simulation model based on Markov cohort methodology that incorporated the features of FRAX. RESULTS: At a threshold of pound 30,000 per QALY, strontium ranelate was generally cost-effective in women from an age of 65 years with prior fracture at the threshold of osteoporosis (i.e., a T-score of -2.5 SD) and in women with a prior fracture (and no information on bone mineral density) from the age of 65 years. At a threshold of pound 20,000, strontium ranelate became cost-effective at a 10-year fracture probability of 25.7% and at 16.9% with a threshold of pound 30,000 for a QALY. CONCLUSIONS: Strontium ranelate is a cost-effective agent for the treatment of established osteoporosis in women over the age of 65 years. Cost-effective scenarios were also found for the prevention and treatment of fractures associated with osteoporosis, in younger women with additional clinical risk factors.
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| 6. |
- Brahm, Helena, et al.
(författare)
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Relationships between bone mass measurements and lifetime physical activity in a Swedish population
- 1998
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Ingår i: Calcified Tissue International. - : Springer Science and Business Media LLC. - 0171-967X .- 1432-0827. ; 62:5, s. 400-412
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Tidskriftsartikel (refereegranskat)abstract
- Lifetime occupational and leisure time activities were assessed by a questionnaire in order to evaluate their relationship to bone mass measurements and biochemical markers of bone metabolism in a population of 61 women and 61 men, randomly selected from a Swedish population register, to represent ages between 22 and 85 years. We also considered possible confounders by using questions about smoking habits, milk consumption, hormone replacement therapy (HRT), and menopausal age. Bone mineral density (BMD) and bone mineral content (bone mass, BMC) of the total body, lumbar spine, and proximal femur (neck, trochanter, Ward's triangle) were measured by dual energy X-ray absorptiometry (DXA), and BMD of the forearm with single energy X-ray absorptiometry (SXA). In addition, both DXA and SXA provided information on bone area. Quantitative ultrasound measurements (QUS) at the heel were performed to assess the speed of sound (SOS) and broadband ultrasound attenuation (BUA). Fasting blood samples were analyzed for biochemical markers of bone metabolism as well as parathyroid hormone (PTH) and total serum calcium. After adjustment for confounding factors, neither BMD nor QUS measurements were consistently related to lifetime leisure time or occupational activities; nor were there any consistent patterns relating biochemical markers of bone metabolism to bone mass measurements. However, physical activity seemed to influence bone mass, area, and width more than density. In men, high levels of leisure time activity were associated with raised values for lumbar spine area (6.2%) and width (3.3%) as well as for femoral neck area (5.5%) compared with their low activity counterpart. Men exposed to high levels of occupational activity demonstrated lower lumbar spine BMD (10.9%) and area (5.3%) than men with low activity levels. Within an unselected Swedish population, estimation of lifetime occupational and sport activities as well as bedrest, using a questionnaire, demonstrated no major effects on bone density. However, the association between high levels of lifetime activity and raised values for bone mass, area, and width indicate that geometrical changes in bone may provide better estimations of mechanically induced bone strength than bone density, at least in men.
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| 7. |
- Danielson, Mats, et al.
(författare)
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Rätt utvärdering ger rätt leverantör
- 2013
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Ingår i: Upphandling24. - Stockholm : Upphandling24. - 1654-725X. ; :5, s. 44-48
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Tidskriftsartikel (refereegranskat)
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| 8. |
- Davidsson, Lars, 1974-
(författare)
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I linje med partiet? : Maktspel och lojalitet i den svenska riksdagen
- 2006
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The preconditions for Swedish MPs’ (Members of Parliament) loyalty to their parliamentary party groups have been modified by two recent constitutional changes: the introduction of preference voting in the electoral system in 1998, and the 1997 reorganisation of the national budgetary process. The main purpose of this thesis is to determine the impact of these reforms on Swedish MPs’ inclination to defect from their party group’s interests. A theory is developed and its propositions empirically tested on the case of the Swedish Parliament. The theory states that the tasks of forming and upholding the party line are delegated from the party group to an elected leadership, and then re-delegated back to individual MPs. The party group leadership acts as a principal, monitoring the adherence of MPs as agents to party group interests in the fulfilment of these tasks. The nature of the interaction varies with the type of parliamentary activity, and the monitoring capacity of the leadership. This theory is strongly supported by Swedish data, and a comparative overview indicates that the theory may also be useful for analysing party loyalty in other parliamentary systems.The thesis uses a mixed methodology design, combining data from a survey study, an interview study, and a document study of Private Member Initiatives.The preference vote reform has increased MPs' willingness to defect, as well as actual defections from their party group’s interests. The effect is, however, mainly limited to electorally vulnerable MPs, who after the reform need to build a personal political profile. The budget reform has decreased defection on budgetary issues, but from a fairly low starting level. A third effect on party loyalty is found, in that the youngest generation MPs are significantly more prone to defect than their colleagues of older generations.
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| 9. |
- Eklund, Ulrik, et al.
(författare)
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Industrial Challenges of Scaling Agile in Mass-Produced Embedded Systems
- 2014
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Ingår i: Agile Methods. Large-Scale Development, Refactoring, Testing, and Estimation. - Cham : Springer. - 9783319143583 - 9783319143576 ; , s. 30-42
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Konferensbidrag (refereegranskat)abstract
- When individual teams in mechatronic organizations attempt to adopt agile software practices, these practices tend to only affect mod- ules or sub-systems. The short iterations on team level do not lead to short lead-times in launching new or updated products since the overall R&D approach on an organization level is still governed by an overall stage gate or single cycle V-model. This paper identifies challenges for future research on how to combine the predictability and planning desired of mechanical manufacturing with the dynamic capabilities of modern agile software development. Scaling agile in this context requires an expansion in two dimensions: First, scal- ing the number of involved teams. Second, traversing necessary systems engineering activities in each sprint due to the co-dependency of software and hardware development.
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| 10. |
- Fransson, Petra, et al.
(författare)
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Mycorrhizal associations and soil properties of native Allanblackia stuhlmannii stands in the Eastern Usambara Mountains, Tanzania
- 2016
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Ingår i: Annals of Applied Biology. - : Wiley. - 0003-4746. ; 169, s. 369-383
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Tidskriftsartikel (refereegranskat)abstract
- Allanblackia stuhlmannii is a tree species currently under domestication. Potential mycorrhizal relationships of A. stuhlmannii and soil properties of native stands were investigated to determine the soil-environmental requirements of the species. Roots and soil samples were collected from five sites with A. stuhlmannii stands along an altitudinal transect in Amani Nature Reserve, Tanzania. Mycorrhizal status was investigated by combining microscopy with molecular analysis of the fungal communities. Soil adjacent to the A. stuhlmannii seedlings was analysed for physical and chemical properties and the sites were characterised. We showed that A. stuhlmannii form symbiosis with arbuscular mycorrhizal fungi, and that there was a diverse microbiome associated with the roots. The soils, classified as Ferralsol and Acrisol, were very well drained, had a pH(CaCl2) generally at or below 4, high exchangeable acidity and content of sesquioxides and low effective cation exchange capacity and concentrations of most nutrients. We conclude that A. stuhlmannii is tolerant to high Al availability and possesses mechanisms for acquisition of P and other macronutrients at low soil availability, possibly through mycorrhizal symbiosis. However, being adapted to low-pH soils, it may be less efficient in acquiring Fe, Mn and/or Zn at higher soil pH. Thus, it may be most suited to introduction on farms situated on acid soils.
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| 11. |
- Gaines, Hans, et al.
(författare)
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Six-week follow-up after HIV-1 exposure: a position statement from the Public Health Agency of Sweden and the Swedish Reference Group for Antiviral Therapy
- 2016
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Ingår i: Infectious Diseases. - : Informa UK Limited. - 2374-4235 .- 2374-4243. ; 48:2, s. 93-98
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Forskningsöversikt (refereegranskat)abstract
- In 2014 the Public Health Agency of Sweden and the Swedish Reference Group for Antiviral Therapy (RAV) conducted a review and analysis of the state of knowledge on the duration of follow-up after exposure to human immunodeficiency virus (HIV). Up until then a follow-up of 12 weeks after exposure had been recommended, but improved tests and new information on early diagnosis motivated a re-evaluation of the national recommendations by experts representing infectious diseases and microbiology, county medical officers, the RAV, the Public Health Agency, and other national authorities. Based on the current state of knowledge the Public Health Agency of Sweden and the RAV recommend, starting in April 2015, a follow-up period of 6 weeks after possible HIV-1 exposure, if HIV testing is performed using laboratory-based combination tests detecting both HIV antibody and antigen. If point-of-care rapid HIV tests are used, a follow-up period of 8 weeks is recommended, because currently available rapid tests have insufficient sensitivity for detection of HIV-1 antigen. A follow-up period of 12 weeks is recommended after a possible exposure for HIV-2, since presently used assays do not include HIV-2 antigens and only limited information is available on the development of HIV antibodies during early HIV-2 infection. If pre- or post-exposure prophylaxis is administered, the follow-up period is recommended to begin after completion of prophylaxis. Even if infection cannot be reliably excluded before the end of the recommended follow-up period, HIV testing should be performed at first contact for persons who seek such testing.
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| 12. |
- Geale, Kirk, et al.
(författare)
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Late Breaking Abstract - NORdic Database for aSThmA Research (NORDSTAR) : Swedish and Finnish patients
- 2018
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Ingår i: European Respiratory Journal. - : European Respiratory Society. - 0903-1936 .- 1399-3003. ; 52
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Background: A cross-border research collaboration was recently initiated across the Nordic countries. These countries maintain population-based registers containing a variety of patient-level health and socioeconomic variables, providing a basis for nation-wide, longitudinal research.Aims and objectives: Describe key characteristics of Swedish and Finnish asthma populations in 2014.Methods: NORDSTAR is a research platform with ethical approval based on Nordic register data. Patients with an asthma diagnosis (ICD-10: J45/46) at any age in specialist care, or ≥2 dispensed respiratory prescriptions (ATC: R03) while aged 6-44, during 2004-2014 were included. Those with diagnosis and treatment pairs unlikely to be asthma were excluded. Demographics (age, sex, income, education level, and urban residence), treatment, comorbidities, and asthma specialist visits in 2014 were described using summary statistics.Results: Finnish comorbidity levels appeared higher than in Sweden. More Finnish patients filled OCS prescriptions (24%) than Swedish patients (20%). Most Swedish patients lived in an urban setting, and the distribution of education level was similar to the general population. Mean family income was 49,960 and 42,840 EUR in Sweden and Finland respectively, while 31% and 44% of patients visited an asthma specialist. Prevalence of asthma was highest among women in both countries, and age distributions were similar.Conclusions: NORDSTAR is a platform for conducting asthma outcomes research in the Nordics. Swedish and Finnish patients appear to be similar in many dimensions except for prevalence of asthma specialist care contacts.
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| 13. |
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| 14. |
- Guerrero-Casado, José, et al.
(författare)
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Assessment of the suitability of latrine counts as an indirect method by which to estimate the abundance of European rabbit populations at high and low abundance
- 2020
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Ingår i: European Journal of Wildlife Research. - : Springer Science and Business Media LLC. - 1612-4642 .- 1439-0574. ; 66:1
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Tidskriftsartikel (refereegranskat)abstract
- Monitoring European rabbit (Oryctolagus cuniculus) populations using suitable methods is crucial, especially in those areas in which endangered predators remain and rabbits occur at low densities. We first counted the number of rabbits, the number of scattered pellets, and the number of latrines counted within 16 plots established in areas of low rabbit density, showing that the number of rabbits counted inside the plots was more closely correlated with the number of pellets counted than with the number of latrines. In addition, no latrines were found in 8 plots. In 53 walking transects, the number of pellets m−2 and the number of latrines km−1 had a positive relationship, but no significant correlation was obtained between the two methods when only the transects with a low rabbit abundance were selected. These results suggest that although counting latrines can be useful to compare areas with different abundances, it may underestimate rabbit abundance at low abundances where counting scattered pellets is, therefore, the most accurate alternative. © 2019, Springer-Verlag GmbH Germany, part of Springer Nature.
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| 15. |
- Johansson, Helena, et al.
(författare)
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10-årsrisken för fraktur. Stöd i behandlingen av osteoporos, enligt preliminära svenska riktlinjer.
- 2011
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Ingår i: Läkartidningen. - : Läkartidningen Förlag AB. - 0023-7205 .- 1652-7518. ; 108:7, s. 336-339
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Risken för fraktur beräknas med FRAX för män och kvinnor, för olika åldrar, för olika BMI och med följande riskvariabler: tidigare osteoporotisk fraktur, höftfraktur hos föräldrar, aktuell rökning, längre tids peroral behandling med kortison någon gång i livet, förekomst av reumatoid artrit, förekomst av andra sjukdomstillstånd som orsakar osteoporos, aktuell alkoholkonsumtion ≥3 enheter och bentäthetsmätning.FRAX finns fritt tillgängligt på Internet.I denna artikel beskrivs bakgrunden till FRAX och dess användning vid diagnostik och behandling av osteoporos.
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| 16. |
- Johansson, Helena, 1981, et al.
(författare)
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FRAX model for 10year fracture risk assessment. Support in the treatment of osteoporosis, according to preliminary Swedish guidelines : FRAX modell för att beräkna 10årsrisken för fraktur. Stöd i behandlingen av osteoporos, enligt preliminära svenska riktlinjer
- 2011
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Ingår i: Läkartidningen. - 0023-7205. ; 108:7, s. 336-9
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Tidskriftsartikel (refereegranskat)abstract
- Risken för fraktur beräknas med FRAX för män och kvinnor, för olika åldrar, för olika BMI och med följande riskvariabler: tidigare osteoporotisk fraktur, höftfraktur hos föräldrar, aktuell rökning, längre tids peroral behandling med kortison någon gång i livet, förekomst av reumatoid artrit, förekomst av andra sjukdomstillstånd som orsakar osteoporos, aktuell alkoholkonsumtion ≥3 enheter och bentäthetsmätning. FRAX finns fritt tillgängligt på Internet. I denna artikel beskrivs bakgrunden till FRAX och dess användning vid diagnostik och behandling av osteoporos.
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| 17. |
- Kanis, John A, et al.
(författare)
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FRAX and its applications to clinical practice
- 2009
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Ingår i: Bone. - : Elsevier BV. - 8756-3282 .- 1873-2763. ; 44:5, s. 734-43
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Tidskriftsartikel (refereegranskat)abstract
- The introduction of the WHO FRAX algorithms has facilitated the assessment of fracture risk on the basis of fracture probability. FRAX integrates the influence of several well validated risk factors for fracture with or without the use of BMD. Its use in fracture risk prediction poses challenges for patient assessment, the development of practice guidelines, the evaluation of drug efficacy and reimbursement, as well as for health economics which are the topics outlined in this review.
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| 18. |
- Lindberg, Anne, et al.
(författare)
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From COPD epidemiology to studies of pathophysiological disease mechanisms : challenges with regard to study design and recruitment process
- 2017
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Ingår i: European Clinical Respiratory Journal. - : Taylor & Francis. - 2001-8525. ; 4
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Tidskriftsartikel (refereegranskat)abstract
- Background: Chronic obstructive pulmonary disease (COPD) is a largely underdiagnosed disease including several phenotypes. In this report, the design of a study intending to evaluate the pathophysiological mechanism in COPD in relation to the specific phenotypes non-rapid and rapid decline in lung function is described together with the recruitment process of the study population derived from a population based study.Method: The OLIN COPD study includes a population-based COPD cohort and referents without COPD identified in 2002–04 (n = 1986), and thereafter followed annually since 2005. Lung function decline was estimated from baseline in 2002–2004 to 2010 (first recruitment phase) or to 2012/2013 (second recruitment phase). Individuals who met the predefined criteria for the following four groups were identified; group A) COPD grade 2–3 with rapid decline in FEV1 and group B) COPD grade 2–3 without rapid decline in FEV1 (≥60 and ≤30 ml/year, respectively), group C) ever-smokers, and group D) non-smokers with normal lung function. Groups A–C included ever-smokers with >10 pack years. The intention was to recruit 15 subjects in each of the groups A-D.Results: From the database groups A–D were identified; group A n = 37, group B n = 29, group C n = 41, and group D n = 55. Fifteen subjects were recruited from groups C and D, while this goal was not reached in the groups A (n = 12) and B (n = 10). The most common reasons for excluding individuals identified as A or B were comorbidities contraindicating bronchoscopy, or inflammatory diseases/immune suppressive medication expected to affect the outcome.Conclusion: The study is expected to generate important results regarding pathophysiological mechanisms associated with rate of decline in lung function among subjects with COPD and the in-detail described recruitment process, including reasons for non-participation, is a strength when interpreting the results in forthcoming studies.
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| 19. |
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| 20. |
- Malinovschi, Andrei, 1978-, et al.
(författare)
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Consequences of Using Post- or Prebronchodilator Reference Values in Interpreting Spirometry
- 2023
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Ingår i: American Journal of Respiratory and Critical Care Medicine. - : American Thoracic Society. - 1073-449X .- 1535-4970. ; 208:4, s. 461-471
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Tidskriftsartikel (refereegranskat)abstract
- RATIONALE: Post-bronchodilator (BD) spirometry is used for diagnosis of chronic obstructive pulmonary disease (COPD). However, pre-BD reference values are used for spirometry interpretation.OBJECTIVES: To compare the resulting prevalence rates of abnormal spirometry and study the consequences of using pre- or post-BD reference values generated within the Swedish CArdioPulmonary bioImage Study (SCAPIS) when interpreting post-BD spirometry in a general population.METHODS: SCAPIS reference values for post-BD and pre-BD spirometry were based on 10,156 and 1,498 never-smoking, healthy participants, respectively. We studied the associations of abnormal spirometry, defined by using pre- or post-BD reference values, with respiratory burden in the SCAPIS general population (28,851 individuals).MEASUREMENTS AND MAIN RESULTS: Bronchodilation resulted in higher predicted median and lower limit of normal (LLN) for FEV1/FVC ratio. The prevalence of post-BD FEV1/FVC < pre-bronchodilator LLN was 4.8% and that of post-BD FEV1/FVC < post-bronchodilator LLN was 9.9% for the general population. An additional 5.1% was identified as having an abnormal post-BD FEV1/FVC ratio and this group had more respiratory symptoms, emphysema (13.5% vs. 4.1%, p<0.001) and self-reported physician-diagnosed COPD (2.8% vs. 0.5%, p<0.001) than subjects with post-BD FEV1/FVC ratio > LLN for both pre- and post-bronchodilation).CONCLUSIONS: Pre- and post-bronchodilator spirometry reference values differ with regard to FEV1/FVC ratio. Use of post-bronchodilator reference values doubled the population prevalence of airflow obstruction; this was related to a higher respiratory burden. Using post-bronchodilator reference values when interpreting post-bronchodilator spirometry might enable identification of individuals with mild disease and be clinically relevant.
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| 21. |
- Nyström, Helena, 1985-, et al.
(författare)
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Prognosis after intensive care for COPD exacerbation in relation to long-term oxygen therapy : a nationwide cohort study
- 2023
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Ingår i: COPD. - : Routledge. - 1541-2555 .- 1541-2563. ; 20:1, s. 64-70
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Tidskriftsartikel (refereegranskat)abstract
- Decisions to admit or refuse admission to intensive care for acute exacerbations of COPD (AECOPD) can be difficult, due to an uncertainty about prognosis. Few studies have evaluated outcomes after intensive care for AECOPD in patients with chronic respiratory failure requiring long-term oxygen therapy (LTOT). In this nationwide observational cohort study, we investigated survival after first-time admission for AECOPD in all patients aged ≥40 years admitted to Swedish intensive care units between January 2008 and December 2015, comparing patients with and without LTOT. Among the 4,648 patients enrolled in the study, 450 were on LTOT prior to inclusion. Respiratory support data was available for 2,631 patients; 73% of these were treated with noninvasive ventilation (NIV) only, 17% were treated with immediate invasive ventilation, and 10% were intubated after failed attempt with NIV. Compared to patients without LTOT, patients with LTOT had higher 30-day mortality (38% vs. 25%; p < 0.001) and one-year mortality (70% vs. 43%; p < 0.001). Multivariable logistic and Cox regression models adjusted for age, sex and SAPS3 score confirmed higher mortality in LTOT, odds ratio for 30-day mortality was 1.8 ([95% confidence interval] 1.5–2.3) and hazard ratio for one-year mortality was 1.8 (1.6–2.0). In summary, although need for LTOT is a negative prognostic marker for survival after AECOPD requiring intensive care, a majority of patients with LTOT survived the AECOPD and 30% were alive after one year.
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| 22. |
- Rothlin Zachrisson, Ninni, et al.
(författare)
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Survival, remission, and quality of life in diabetic cats
- 2023
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Ingår i: Journal of Veterinary Internal Medicine. - : Wiley. - 0891-6640 .- 1939-1676. ; 37, s. 58-69
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundRemission is documented in a substantial proportion of cats with diabetes. The effects of diabetes mellitus (DM) on the lives of cats and their owners should be considered when evaluating treatment success. ObjectivesTo study outcome in cats with DM and the impact DM has on the life situation of cat and owner. AnimalsDomestic and pedigree cats with a diagnosis of DM (n = 477) insured by a Swedish insurance company during 2009 to 2013. MethodsRetrospective cross-sectional study. A questionnaire was sent to 1369 owners of cats diagnosed with DM. The questions concerned the cat, treatment, owner perceptions of the disease and treatment and disease outcome. Data were analyzed using multiple linear and logistic regression, with outcomes set as survival for more than 4 weeks after diagnosis, survival time, achieving remission, remission without relapse and quality of life (QoL) for the cat. ResultsThe response rate was 35%, leaving 477 questionnaires for analysis. The remission rate among treated cats was 29% (118/405). Feeding a commercially available wet diet was associated with both remission (OR 3.16, 95% confidence interval 1.27-8.12) and remission without relapse (OR 14.8, 95% confidence interval 2.25-153.8). Remission was associated with a better QoL for the cat. Conclusions and Clinical ImportanceThe association between feeding a commercially available wet diet and remission is important and strengthens the role of diet in treatment of DM in cats. Linking remission and a better QoL for the cat emphasizes remission as a goal in disease management.
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| 23. |
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| 24. |
- Ström, Helena, 1985, et al.
(författare)
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Quality of Life in Parents/Caretakers of Children with Cerebral Palsy in Kampong Cham, Cambodia.
- 2012
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Ingår i: Journal of tropical pediatrics. - : Oxford University Press (OUP). - 1465-3664 .- 0142-6338. ; 58:4, s. 303-306
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Tidskriftsartikel (refereegranskat)abstract
- The purpose of this study was to investigate QOL in parents/caretakers of children with cerebral palsy in the province of Kampong Cham, Cambodia. Forty parents/caretakers of children with cerebral palsy aged 1-13 years (F19/M21) participated in this study. The study was carried out using the Comprehensive Quality of life Scale A5 (ComQOL-A5) questionnaire. Results point out three major domains where quality of life is unsatisfactory: health, material well-being and emotional well-being. Of these areas, QOL in the health domain demonstrates the lowest scores. Results support a further commitment in providing comprehensive rehabilitation for parents and their children with CP in Kampong Cham. This study identifies the need for further research on QOL in parents/caretakers of children with CP in Cambodia and the need for development of valid and reliable QOL instruments targeting the developing world.
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| 25. |
- Ström Öhlund, Helena, 1985, et al.
(författare)
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Anxiety management: Participants’ experiences of a physiotherapeutic group treatment in Swedish psychiatric outpatient care
- 2020
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Ingår i: Physiotherapy Theory and Practice. - : Informa UK Limited. - 0959-3985 .- 1532-5040. ; 36:2, s. 276-290
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Tidskriftsartikel (refereegranskat)abstract
- © 2018 Taylor & Francis Anxiety disorders are among the most persistent mental health syndromes. There is extensive research showing effectiveness of pharmacotherapy and psychotherapy interventions targeting anxiety, while knowledge is still sparse for other treatment options. The aim of this study was to explore how participants with anxiety disorders experience a physiotherapeutic group treatment in psychiatric outpatient care, and their perceived ability to manage anxiety within two months after participating in the treatment. Semi-structured interviews with participants were conducted to explore experiences of the treatment. Data were analyzed using qualitative content analysis, which resulted in one main theme: Reconnecting to the body in the supportive atmosphere of a group. Six categories reflect the main theme: (1) sharing with others supported by the group, (2) grounding oneself in the body, (3) getting to know the body and learning to manage its reactions, (4) learning to tolerate bodily sensations of anxiety, (5) gaining a more compassionate attitude toward oneself, and (6) challenging old patterns to become more active in life. The participants reported that their ability to reconnect to their bodies increased so that anxious sensations became more endurable and acceptable after treatment. The supportive group context was described as valuable, enabling the participants to feel safe enough to start exploring new ways to manage anxiety. In conclusion, this study suggests that a physiotherapeutic group treatment can be a useful add-on treatment to the standard treatment models of anxiety disorders, including psychotherapy and pharmacotherapy, since it targets the embodied, nonverbal domain of anxiety.
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| 26. |
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| 27. |
- Wangefelt Ström, Helena, 1968-
(författare)
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Döden i souvenirbutiken : Kvarlevor som kult och kuriosa
- 2013
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Ingår i: Kulturella perspektiv - Svensk etnologisk tidskrift. - Umeå : Föreningen Kulturella perspektiv. - 1102-7908. ; :2, s. 20-26
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Tidskriftsartikel (refereegranskat)abstract
- Death in the souvenir shop: Mortal remains as cult and curiositiesMuseums, heritage production and Christian relics all deal with and are built on death in various aspects. Transferring an everyday object into the museum sphere can be regarded as an intentional death, a rebirth to a new identity and a new context. Relics are the byproducts of death, given a new life as subject to religious veneration. When inscribed in yet another context of heritage, musealisation and tourism, they can once again be regarded as dead and resurrected to a new life and identity. When saintly bones journey from human life through death, sacredness, political power and tourism, to something for sale in the souvenir shop, is it layer upon layer of death – or an endless chain of resurrections and new lives?
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| 28. |
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| 29. |
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| 30. |
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| 31. |
- Wangefelt Ström, Helena, 1968-
(författare)
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Helighet på museum
- 2012
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Ingår i: Tidskriften Evangelium. - 2001-6808. ; :2
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Tidskriftsartikel (populärvet., debatt m.m.)
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| 32. |
- Wangefelt Ström, Helena, 1968-
(författare)
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Helighet på museum
- 2013
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Ingår i: Strukturer, arvet, prästen, avförtrollning. - : GAudete. - 9789186577377 ; , s. 105-107
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Bokkapitel (populärvet., debatt m.m.)
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| 33. |
- Wangefelt Ström, Helena, 1968-
(författare)
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Heligt, hotfullt, historiskt : kulturarvifieringen av det katolska i 1600-talets Sverige
- 2011
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Ingår i: Lychnos. - Uppsala. - 0076-1648. ; , s. 29-53
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Tidskriftsartikel (refereegranskat)abstract
- Heligt – Hotfullt – Historiskt: Kulturarvifieringen av det katolska i 1600-talets SverigeHelena Wangefelt StrömAbstractThis article aims at bringing together two concepts with many similarities, heritage and sacredness, using theories presently under construction in an international and interdisciplinary research field dealing with heritage production, politics and power. Focus is on the process and the agenda more than the product, and particularly on the transvaluation taking place when something is given a heritage status: the form is intact, but the content is new and different. These theories are applied on a 17th century Swedish national inquiry for historical remains or ”antiquities”, ordered by the King and performed by the local clergy, an inquiry where not only the expected and specifically requested runic stones, pre-historic graves or famous battle fields were listed, but in many cases also far more recent Catholic items and memories, thus transformed from sacred objects to a part of the national heritage. The hypothesis presented and argued for is that this listing and, in fact, heritage production also worked as an act of control and domestication of the potentially dangerous: the threatening, former sacred, was made harmless when – literally or figuratively – locked up in a museum case.
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| 34. |
- Wangefelt Ström, Helena, 1968-, et al.
(författare)
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Heritage Politics and Identity
- 2020
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Ingår i: ANANKE Quadrimestrale di cultura, storia e techniche della conservazione. - Milano. - 1129-8219. ; :89, s. 121-127
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Tidskriftsartikel (refereegranskat)abstract
- Il contributo presenta il lavoro svolto dagli studenti del corso Heritage Politics and Identity presso Uppsala University Campus Gotland, riflettendo sul significato di heritage e i suoi legami con l'identità culturale e la politica. Dopo una breve introduzione sull'approccio verso la patrimonializzazione tenuto nel corso, si presentano le interessanti ricerche di alcuni studenti, con provenienza da tutto il mondo, che variano da riflessioni su le nomine UNESCO, post-colonialismo e diritti umani, accessibilità, turismo e gestione del patrimonio.
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| 35. |
- Wangefelt Ström, Helena, 1968-, et al.
(författare)
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History Unfolds : Andligt kulturarv - Religion, mångfald och museer
- 2016
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Annan publikation (ljud/tal) (populärvet., debatt m.m.)abstract
- Andligt kulturarv – Religion, mångfald och museer. I de flesta museisamlingar finns föremål från olika religioner. På Historiska museet finns t ex en stor samling medeltida kyrkokonst. Sverige är ett sekulariserat land, hur påverkar det religiösa kulturarvet oss idag? Och vilken roll kan museer spela i diskussioner om de existentiella utmaningar som samhället står inför idag? Vilka frågor och ställningstaganden är viktiga? Medverkande: David Thurfjell, professor i religionsvetenskap vid Södertörns högskola, James Webb, konstnär, Maria Kjellsdotter Rydinger, präst och projektledare för ”Tillsammans för Sverige”, samt Helena Wangefelt Ström, forskare i museologi vid Umeå universitet.
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| 36. |
- Wangefelt Ström, Helena, 1968-
(författare)
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How do Museums Affect Sacredness? : Three Suggested Models
- 2019
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Konferensbidrag (refereegranskat)abstract
- This paper discusses what happens when religion in the shape of objects imbued with religious meaning is transformed into cultural heritage, suggesting three models to discuss its consequences for museums.The first model builds on the museum as a killing of previous identities, and the objects as provided with new identities as museum objects. A second model is the hybrid identity, where a museum object can possess several identities simultaneously, depending on the eyes of the beholder: sacredness, art object, or evidence of history. The third model is defined by the uses of objects. Distinguishing between cultual use and cultural use is crucial here. I argue that these different approaches to sacred objects in museum pose different museological challenges and possibilities, and also ascribes different agencies to museum staff as well as to the visitors.
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| 37. |
- Wangefelt Ström, Helena, 1968-
(författare)
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Kulturarv: ikon för en sekulariserad tid
- 2006
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Ingår i: Kulturella perspektiv - Svensk etnologisk tidskrift. - Umeå. - 1102-7908. ; 15:3, s. 67-76
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Tidskriftsartikel (refereegranskat)abstract
- This article examines how the term 'holiness' can be applied to the discussion about cultural heritage, and raises the question whether cultural heritage might even have substituted institutionalized religion as an object of devotion in a secularized society. A comparison between the religious field and the heritage field is performed by studying two specific examples, the Trinity icon by Andrej Rublev and the medieval wall surrounding the city of Visby, Sweden. Different aspects of these examples are examined, such as Creating distance - creating intimacy; Pedagogical example - The real thing; Who is the subject, who's zoomin' who?; The bless and to petrify; Between preservation and use, form and function. The parallells between the religious field and the heritage field end up in a conclusion that 'holiness' needs to be re-introduced as a factor - not least in a time and society of increasing cultural diversity.
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| 38. |
- Wangefelt Ström, Helena, 1968-
(författare)
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Lighting candles before a headless Jesus : sacred heritage, heritagized sacredness, and the many journeys between categories
- 2022
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The overarching aim of this thesis, situated within Museology and Heritage Studies, is to investigate the different modes and devices of transfer between sacredness and heritage. The research question, 'What happens in the transfer between heritage and sacredness?', is investigated as production of sacred heritage in early modern Europe and specifically Sweden, Rome, and Venice (Part I), and as uses of the sacred as heritage in different times and contexts (Part II). The research question is investigated by applying three core analytical lenses: Time (to Part I), Uses (to Part II), and concluding by consolidating Agents to the final discussion and conclusions. The analysis draws upon Habermas and Taylor’s respective theories and concepts regarding post-secularism, and Latour’s concepts of 'agent collectives' conceptual 'imbroglios' is used to explain transfers between categories presented in Part I and II.Using a variety of sources as case studies, this study further elucidates new categories created for sacred heritage and how these adapt to new uses. This research provides an analysis of the fluidity and complexity of categories at the intersection of religion and heritage. The thesis suggests new models to apply to religious and sacred artefacts that address their classification complexity and further corresponding to religious audiences today. The thesis argues that heritage as a concept and the creation of museums, in scholarship often referred to as post-Enlightenment phenomena, can be identified already in the post- Reformation period. Further, the thesis argues that the separation of 'sacred' and 'profane' as categories in early modernity, intended to protect the sacred from profanation and harm, facilitated a secular understanding and a possibility to de-select sacredness, thereby creating sacredness as 'heritage'. A secular way of narrating and explaining religion in museums and heritage contexts was exported globally with the western museum template and the Latin Christian understanding of time and materiality. Extending the consequences of the transformations addressed in the research question into the challenges in societies today, the thesis argues that religious literacy and a post-secular competence are needed to make informed decisions for a resilient society – not least within heritage management.
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| 39. |
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| 40. |
- Wangefelt Ström, Helena, 1968-, et al.
(författare)
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Omne malum ab Aquilone : images of the evil North in early modern Italy and their impact on cross-religious encounters
- 2018
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Ingår i: Visions of North in premodern Europe. - Turnhout : Brepols. - 9782503574752 - 9782503574769 ; , s. 265-286
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Bokkapitel (refereegranskat)abstract
- Destructive, infertile, intellectually inferior, and the home of witches and werewolves. A northern visitor to southern Europe in the early modern period travelled — willingly or not — into a world imbued with forceful associations related to the North that were well estab- lished, historically rooted, and alive in the minds of the people in the South. These concepts, mythological images, and archetypes were well known also by the northerners themselves, and were, contrary to what one might expect, not merely a yoke of negative expectations but also in some cases cleverly used to enhance certain aspects of a constructed image or a desired reputation. This article wishes to bring forth some of these images, and give examples of how they were used and affected in particular the religious relations between North and South in the post-Reformation period.
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| 41. |
- Wangefelt Ström, Helena, 1968-
(författare)
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Religion in Museums: Euthanized Sacredness, in the Beholder’s Eye, or a Multi-Tool for Shifting Needs? : Three suggested models to discuss how museums affect sacredness
- 2018
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Ingår i: Museology and the Sacred. Papers for discussion. - Paris : ICOFOM (International committee for museology). - 9789290124481 ; , s. 223-228
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- What happens when religion in the shape of objects imbued with religious meaning is transformed into cultural heritage? What values are added, what are lost, and who is the performing agent? These questions concern what museums do to objects connected to religion, calling for a meditated use of terms such as holy, sacred, religious, and spiritual (all employed in recent research and policy documents by, for example, UNESCO, while in many cases as interchangeable). This paper suggests three models to understand the processes of heritagisation of religion and the factors and agents involved, starting from a historical background in European, in particular Italian, Early Modernity. A frequently used scholarly model depicts the museum as a killing of previous identities, and the objects as provided with entirely new identities, and lives, as museum objects. This view brings on dramatic effects for sacred objects, how they are handled and narrated in the museum, and possibly on how they are viewed by the visitors. The use or not of information signs before sacred objects in museums is an aspect on this matter. The second model is the hybrid identity, where a museum object can be said to possess two authentic identities simultaneously, depending on the views and beliefs of the beholder: authentic sacredness, or authentic art object and evidence of history. This view may fit well with the focus on the individual in our time. The third model presented is based on the two previous ones, and suggests a hybridity not only in identities or living/dead, but defined by the uses of the objects. Even musealized objects can, as in the cases of religious treasuries or of certain religious images in museums, shift identity between museum object, object of devotion (to be carried in processions or used in rituals), legitimization symbol (bishops’ ordinations etc), and, historically, as a monetary reserve to be sold if needed. The identity of the object shifts, also in practice of being looked at behind glass or being used and touched, depending on the use currently applied to it. A distinction between cultual use and cultural use is relevant for this model. I argue that these different approaches to sacred objects in museum pose different museological challenges and possibilities, and also ascribes different agencies to museum staff as well as to the visitors.
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| 42. |
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| 43. |
- Öhlund, Malin, et al.
(författare)
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Environmental Risk Factors for Diabetes Mellitus in Cats
- 2017
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Ingår i: Journal of Veterinary Internal Medicine. - : WILEY. - 0891-6640 .- 1939-1676. ; 31:1, s. 29-35
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundDiabetes in cats resembles type 2 diabetes in people. The etiology is not fully understood, but both genetic and environmental factors are believed to contribute. ObjectivesTo assess the associations of environmental risk factors with diabetes in cats. AnimalsCats with a diagnosis of diabetes (n = 396) insured by a Swedish insurance company during years 2009-2013, and a control group (n = 1,670) matched on birth year. MethodsA web-based questionnaire was used in a case-control study. An invitation to participate was sent to owners of 1,369 diabetic cats and 5,363 control cats. The survey contained questions related to the cat's breed, age, sex, neutering status, body condition, housing, access to the outdoors, activity level, diet, eating behavior, feeding routine, general health, stressful events, other pets in the household, medications, and vaccination status. Data were analyzed by multiple logistic regression. ResultsResponse rate was 35% for the diabetic group and 32% for the control group. Indoor confinement, being a greedy eater, and being overweight were associated with an increased risk of diabetes. In cats assessed by owners as being normal weight, there was an association between eating predominantly dry food and an increased risk of diabetes (Odds ratio 3.8; 95% confidence intervals 1.3-11.2). Conclusions and Clinical ImportanceDry food is commonly fed to cats worldwide. The association found between dry food and an increased risk of diabetes in cats assessed as normal weight by owners warrants further attention.
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| 44. |
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