| 1. |
- Anund, Anna, et al.
(författare)
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Utveckling och prövning av ny skolskjutsskylt
- 2010
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- I samband med av- och påstigning av buss utsätts passagerare för risker från övrig trafik. Barn är speciellt utsatta i samband med färd till och från skolan och det finns därför starka skäl att försöka förmå de fordon som passerar en stillastående skolskjuts att sänka hastigheten rejält. Med erfarenheterna från 30-projektet som bakgrund beslutades att föreslå ett införande av en 30-gräns vid stillastående skolskjuts i hela landet på vägar med hastighetsgränser 70 km/h och lägre. Inför en sådan eventuell lagändring är det viktigt att utforma en skolskjutsskylt som respekteras av alla trafikanter. I ett laboratorietest jämfördes hur iögonfallande fyra skyltar vars budskap varierade var, jämfört med fyra skyltar som hela tiden visade ett och samma budskap. Delvis med laboratoriestudiens resultat som bakgrund, testades i ett fältförsök två skyltar med varierande budskap mot tre skylar som visade en enda symbol. I en tredje studie undersöktes efterlevnaden av några av de skyltar som studerats tidigare. Hastigheten mättes för fordon som passerade en stillastående buss försedd endera med en digital 30-skylt med röd bård, en digital 30-skylt utan bård, en digital skylt med varierande symbol och en traditionell skolskjutsskylt.
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| 2. |
- Bergqvist, Lennart, et al.
(författare)
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Particle sizing and biokinetics of interstitiallymphoscintigraphic agents
- 1983
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Ingår i: Seminars in Nuclear Medicine. - 0001-2998. ; 13:1, s. 9-19
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Tidskriftsartikel (refereegranskat)abstract
- The biokinetics of inert lymphoscintigraphic agentsstrongly depends on their particle size. Different techniques for characterization of colloids are discussed. Experiments have been performed on eight different colloids. The particle size has been investigated with scanning electron microscopy. Activity distributions have been obtained with ultrafiltration and gel-column scanning technique. The colloids suggested for lymphoscintigraphy were found to have a median size of about 40-50 nm except one minimicro-aggregated human serum albumin colloid which has a median particle size around 10 nm. The biokinetics were studied with a scintillation camera in rabbits after a subcutaneous injection. Timeactivity curves were generated. After 5 hr the rabbits were dissected and the activity content in different tissues measured. A compartment model for the biokinetics was designed and rate constants evaluated. The total and specific activity uptake in parasternal lymph nodes was highest for the small-particle colloids. The compartment model showed a good fitting to the experimental data.
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| 3. |
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| 4. |
- Dimova, Tanya, et al.
(författare)
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Maternal Foxp3 expressing CD4+ CD25+ and CD4+ CD25- regulatory T-cell populations are enriched in human early normal pregnancy decidua : a phenotypic study of paired decidual and peripheral blood samples.
- 2011
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Ingår i: American Journal of Reproductive Immunology and Microbiology. - : John Wiley & Sons. - 8755-8920 .- 1046-7408. ; 66:Suppl 1, s. 44-56
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Tidskriftsartikel (refereegranskat)abstract
- PROBLEM: Regulatory T cells (Treg cells), a small subset of CD4(+) T cells maintaining tolerance by immunosuppression, are proposed contributors to the survival of the fetal semiallograft. We investigated Treg cells in paired decidual and peripheral blood (PB) samples from healthy women in early pregnancy and PB samples from non-pregnant women.METHOD OF STUDY: Distribution, location, cytokine mRNA, and phenotype were assessed in CD4(+) CD25(+) Treg cells from paired samples using immunohistochemistry, immunofluorescence, flow cytometry, and real-time quantitative RT-PCR.RESULTS: The presence and in situ distribution of CD4(+) Foxp3(+) Treg cells in decidua are hereby demonstrated for the first time. Three Foxp3(+) cell populations, CD4(+) CD25(++) Foxp3(+), CD4(+) CD25(+) Foxp3(+), and CD4(+) CD25(-) Foxp3(+), were enriched locally in decidua. In contrast, no statistically significant difference in numbers of circulating Treg cells between pregnant and non-pregnant women was found. The Foxp3(+) cells expressed the surface molecules CD45RO, CTLA-4, CD103, Neuropilin-1, LAG-3, CD62L, and TGFβ1 mRNA consistent with Treg phenotype. The population of CD4(+) CD25(-) Foxp3(+) cells, not described in human decidua before, was enriched 10-fold compared with PB in paired samples. Their cytokine expression was often similar to Th3 profile, and the Foxp3 mRNA expression level in CD4(+) CD25(-) cells was stable and comparable to that of CD4(+) CD25(+) Treg cells implying that the majority of CD4(+) CD25(-) Foxp3(+) cells might be naïve Treg cells.CONCLUSION: (i) There is a local enrichment of Treg cells in decidua (ii) The exclusive accumulation of decidual CD4(+) CD25(-) Foxp3(+) cells suggests an additional reservoir of Foxp3(+) naïve Treg cells that can be converted to 'classical' Treg cells in uterus.
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| 5. |
- Eriksson, Yvonne, et al.
(författare)
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Statistics for children
- 2009
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Ingår i: DD4D, Data Design 4 Decisions, OECD and IIID. - Paris.
-
Konferensbidrag (refereegranskat)abstract
- This paper discusses the ability to present statistics to children, and it suggests that visualizations facilitate interpretations of complex numerical data. Statistics are often a basis for decisions, and children are able to make their own decisions to some extent. Therefore it is necessary to discuss how statistics for children can be designed. Three different examples will be discussed in relation to the role of visual representations in making abstract numbers concrete for children.
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| 6. |
- Huss, Magnus, 1979-, et al.
(författare)
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Influence of growth history on the accumulation of energy reserves and winter mortality on young fish
- 2008
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Ingår i: Canadian Journal of Fisheries and Aquatic Sciences. - : EBSCO Host. - 0706-652X .- 1205-7533. ; 65:10, s. 2149-2156
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Tidskriftsartikel (refereegranskat)abstract
- In seasonal environments accumulated energy reserves are important to avoid starvation mortality during periods of low resource levels. Here we investigated patterns of energy accumulation and the importance of growth history for winter survival in young-of-the-year Eurasian perch (Perca fluviatilis). Under simulated winter conditions in aquaria’s we showed that high winter mortality most likely relate to the depletion of energy reserves in small perch. Correspondingly in a field study, using 4 lakes covering 3-6 lake years each, overwinter survival within cohorts was positively related to individual size. However, average size in autumn did not explain the variation in overwinter survival between cohorts. Instead we showed that seasonal growth history is an important factor. High growth rates late in season may increase cohort survival over winter irrespective of average size, related to a positive growth dependent increase in allocation to energy reserves when approaching winter. Mechanisms regulating within-season temporal dynamics of growth rates are therefore suggested to be important for overall cohort performance.
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| 7. |
- Kjær, Kasper Skov, et al.
(författare)
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Luminescence and reactivity of a charge-transfer excited iron complex with nanosecond lifetime
- 2019
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 363:6424, s. 249-253
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Tidskriftsartikel (refereegranskat)abstract
- Iron’s abundance and rich coordination chemistry are potentially appealing features for photochemical applications. However, the photoexcitable charge-transfer (CT) states of most Fe complexes are limited by picosecond or sub-picosecond deactivation through low-lying metal centered (MC) states, resulting in inefficient electron transfer reactivity and complete lack of photoluminescence. Here we show that octahedral coordination of Fe(III) by two mono-anionic facial tris-carbene ligands can suppress such deactivation dramatically. The resulting complex [Fe(phtmeimb)2]+, where phtmeimb is [phenyl(tris(3-methylimidazol-1-ylidene))borate]-, exhibits strong, visible, room temperature photoluminescence with a 2.0 ns lifetime and 2% quantum yield via spin-allowed transition from a ligand-to-metal charge-transfer (2 LMCT) state to the ground state (2 GS). Reductive and oxidative electron transfer reactions were observed for the2 LMCT state of [Fe(phtmeimb)2]+ in bimolecular quenching studies with methylviologen and diphenylamine.
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| 8. |
- Kristensen, L. E., et al.
(författare)
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Societal costs and patients' experience of health inequities before and after diagnosis of psoriatic arthritis: a Danish cohort study
- 2017
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Ingår i: Annals of the Rheumatic Diseases. - : BMJ. - 0003-4967 .- 1468-2060. ; 76:9, s. 1495-1501
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Tidskriftsartikel (refereegranskat)abstract
- Objectives To comprehensively study the comorbidities, healthcare and public transfer (allowance) costs in patients with psoriatic arthritis (PsA) before and after diagnosis. Methods Nationwide cohort study, using data from Danish registries from January 1998 through December 2014. A total of 10 525 patients with PsA and 20 777 matched general population comparator (GPC) subjects were included. Societal costs, employment status and occurrence of comorbidities in patients with PsA both before and after diagnosis were compared with GPC subjects. Results At baseline, patients with PsA had significantly more comorbidities, including cardiovascular disease (OR 1.70 95% CI 1.55 to 1.86), respiratory diseases (OR 1.73 95% CI 1.54 to 1.96) and infectious diseases (OR 2.03 95% CI 1.69 to 2.42) compared with GPC subjects. At all time points, patients with PsA had higher total healthcare and public transfer costs; they also had lower income (p<0.001) and incurred a net average increased societal cost of (sic)10 641 per patient-year compared with GPC subjects following diagnosis. The relative risk (RR) for being on disability pension 5 years prior to PsA diagnosis was 1.36 (95% CI 1.24 to 1.49) compared with GPC subjects. The RR increased to 1.60 (95% CI 1.49 to 1.72) at the time of diagnosis and was 2.69 (95% CI 2.40 to 3.02) 10 years after diagnosis, where 21.8% of the patients with PsA received disability pension. Conclusions Our findings are suggestive of health inequity for patients with PsA and call for individual preventive measures and societal action.
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| 9. |
- Larsson, Jörgen, et al.
(författare)
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Distribution of iodine 125-labeled alpha1-microglobulin in rats after intravenous injection
- 2001
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Ingår i: Journal of Laboratory and Clinical Medicine. - : Elsevier BV. - 0022-2143 .- 1532-6543. ; 137:3, s. 165-175
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Tidskriftsartikel (refereegranskat)abstract
- The 28-kd plasma protein alpha(1)-microglobulin is found in the blood of mammals and fish in a free, monomeric form and as high-molecular-weight complexes with molecular masses above 200 kd. In this study, iodine 125-labeled free and high-molecular weight rat alpha(1)-microglobulin (a mixture of alpha(1)-microglobulin/alpha(1)-inhibitor-3 and alpha(1)-microglobulin/fibronectin complexes) were injected intravenously into rats. The distribution of the proteins was measured by using scintillation camera imaging. Both forms of (125)I-labeled alpha(1)-microglobulin were rapidly cleared from the blood, with a half-life of 2 and 16 minutes for the initial and late phase, respectively, for free alpha(1)-microglobulin; and a half-life of 3 and 130 minutes for the initial and late phase, respectively, for the complexes. After 45 minutes, 6%, 16%, 27%, 13%, and 34% of the free (125)I-labeled alpha(1)-microglobulin and 18%, 21%, 6%, 10%, and 42% of the (125)I-labeled alpha(1)-microglobulin complexes were found in the blood, gastrointestinal tract, kidneys, liver, and the remainder of the body, respectively. The local distribution of injected (125)I-labeled alpha(1)-microglobulin in intestines and kidneys was investigated by microscopy and autoradiography. In the intestine, both forms were distributed in the basal layers, villi, and luminal contents. The results also suggested intracellular labeling of epithelial cells. Well-defined local regions containing higher concentrations of injected protein could be seen in the intestine. In the kidneys, both forms were found mostly in the cortex. Free (125)I-labeled alpha(1)-microglobulin was found predominantly in epithelial cells of a subset of the tubules, whereas the (125)I-labeled complexes were more evenly distributed. Intracellular labeling was indicated for both alpha(1)-microglobulin forms. The results thus indicate a rapid transport of (125)I-labeled alpha(1)-microglobulin from the blood to most tissues.
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| 10. |
- Larsson, K, et al.
(författare)
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The Saccharomyces cerevisiae SOP1 and SOP2 genes, which act in cation homeostasis, can be functionally substituted by the Drosophila lethal(2)giant larvae tumor suppressor gene.
- 1998
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Ingår i: The Journal of biological chemistry. - : Elsevier BV. - 0021-9258 .- 1083-351X. ; 273:50, s. 33610-8
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Tidskriftsartikel (refereegranskat)abstract
- By complementation of a salt-sensitive mutant of Saccharomyces cerevisiae, we cloned the SOP1 gene, encoding a 114.5-kDa protein of 1033 amino acids. Cells deleted for SOP1 exhibited sensitivity to sodium stress, but showed no sensitivity to general osmotic stress. Following exposure of sop1Delta cells to NaCl stress, the intracellular Na+ level and the Na+/K+ ratio rose to values significantly higher than in wild type cells. Deletion of SOP2, encoding a protein sharing 54% amino acid identity with Sop1p, produced only slight Na+ sensitivity. Cells carrying a sop1Deltasop2Delta double deletion became, however, hypersensitive to Na+ and exhibited increased sensitivity also to Li+ and K+, suggesting involvement of both SOP1 and SOP2 in cation homeostasis. The predicted amino acid sequences of Sop1p and Sop2p show significant homologies with the cytoskeletal-associated protein encoded by the Drosophila lethal(2)giant larvae tumor suppressor gene. Immunolocalization of Sop1p revealed a cytoplasmic distribution and cell fractionation studies showed that a significant fraction of Sop1p was recovered in a sedimentable fraction of the cytosolic material. Expression of a Drosophila l(2)gl cDNA in the sop1Deltasop2Delta strain partially restored the Na+ tolerance of the cells, indicating a functional relationship between the Sop proteins and the tumor suppressor protein, and a novel function in cell homeostasis for this family of proteins extending from yeast to human.
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| 11. |
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| 12. |
- Lindén, Ola, et al.
(författare)
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Radioimmunotherapy using 131I-labeled anti-CD22 monoclonal antibody (LL2) in patients with previously treated B-cell lymphomas
- 1999
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Ingår i: Clinical Cancer Research. - 1078-0432. ; 5:10 Suppl, s. 3287-3291
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Tidskriftsartikel (refereegranskat)abstract
- Experience in using rapidly internalizing antibodies, such as the anti-CD22 antibody, for radioimmunotherapy of B-cell lymphomas is still limited. The present study was conducted to assess the efficacy and toxicity of a 131I-labeled anti-CD22 monoclonal antibody (mAb), LL2, in patients with B-cell lymphomas failing first- or second-line chemotherapy. Eligible patients were required to have measurable disease, less than 25% B cells in unseparated bone marrow, and an uptake of 99mTc-labeled LL2Fab' in at least one lymphoma lesion on immunoscintigram. Eight of nine patients examined with immunoscintigraphy were unequivocally found to have an uptake, and therapy with 131I-labeled anti-CD22 [1330 MBq/m2 (36 mCi/m2)] preceded by 20 mg of naked anti-CD22 mAb was administered. Three patients achieved partial remission (duration, 12, 3, and 2 months), and one patient with progressive lymphoma showed stable disease for 17 months. Four patients exhibited progressive disease. The toxicity was hematological. Patients with subnormal counts of neutrophils or platelets before therapy seemed to be more at risk for hematological side effects. Radioimmunotherapy in patients with B-cell lymphomas using 131I-labeled mouse anti-CD22 can induce objective remission in patients with aggressive as well as indolent lymphomas who have failed prior chemotherapy.
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| 13. |
- Pettersson, Rune, et al.
(författare)
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Applying ID Processes To Vodcast Design For Education And Information.
- 2008
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Ingår i: Visual literacy beyond frontiers, information, culture and diversity. - 9780981683362 ; , s. 55-62
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Konferensbidrag (refereegranskat)abstract
- The podcast phenomenon has gained considerable momentum in various educational contexts around the world. For this project we have studied opinions and views expressed by subjects regarding an experimental visual literacy podcast that was demonstrated to subjects in the USA and in Sweden. It was concluded that it is not possible to please all subjects in a diverse audience. The intended audience must be carefully identified, and the program designed to cater for specific needs. Information design principles regarding legibility and reading on screens can be applied to the design of video-podcasts for education, information and training purposes.
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| 14. |
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| 15. |
- Pettersson, Rune, et al.
(författare)
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Book Margins And Page Numbers
- 2009
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Ingår i: Engaging Creativity & Critical Thinking. - 9780981683379 ; , s. 155-162
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Konferensbidrag (refereegranskat)abstract
- The standard medieval margins were in general more generous than those we have in today’s books. A common layout traditionally had more space at the bottom, and on the outside margins, as compared with today’s books, where margins can be a mere 10 millimetres wide. It varies a lot where page numbers are placed in printed books. Sometimes page numbers are placed at the bottom of the page, sometimes at the top; sometimes the page number is placed to the right, and sometimes to the left, or in the middle of the page. Usually page numbers are placed at the bottom of the page.
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| 16. |
- Porathe, Thomas, et al.
(författare)
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Which sign is more visible? : Measuring the visibility of traffic signs through the conspicuity index method
- 2011
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Ingår i: European Transport Research Review. - : Springer Science and Business Media LLC. - 1867-0717 .- 1866-8887. ; 3:1, s. 35-45
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: A new method of measuring visibility taking context into account introduced by Alexander Wertheim has been validated in this study. The purpose was to see if a simple and practical technique could render robust and useful quantitatively measurable results. Methods: An ordinary traffic sign, placed against different backgrounds, was used as a target. Subjects were told to fixate the sign and then slowly deviate with their gaze until they could no longer see the sign in the corner of their eye. This angle was then used as an index for conspicuity. A simple paper and pen method was tested as well as a computer based method. Results: Results for the paper and pen method showed low variance among subjects and a clear correlation between the conspicuity index and intuitive judgments of the visibility of the signs against different backgrounds. For the computer based method the variability was higher but the results still significant between the two groups of dynamic versus static signs. Conclusions: The conclusion is that the conspicuity index method is a simple and useful method that renders quantitative measurements of the visibility of targets taken context into account.
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| 17. |
- Prakash, Om, et al.
(författare)
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A Stable Homoleptic Organometallic Iron(IV) Complex
- 2020
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Ingår i: Chemistry - A European Journal. - : WILEY-V C H VERLAG GMBH. - 0947-6539 .- 1521-3765. ; 26:56, s. 12728-12732
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Tidskriftsartikel (refereegranskat)abstract
- A homoleptic organometallic Fe(IV)complex that is stable in both solution and in the solid state at ambient conditions has been synthesized and isolated as [Fe(phtmeimb)(2)](PF6)(2)(phtmeimb=[phenyl(tris(3-methylimidazolin-2-ylidene))borate](-)). This (FeN)-N-IV-heterocyclic carbene (NHC) complex was characterized by(1)H NMR, HR-MS, elemental analysis, scXRD analysis, electrochemistry, Mossbauer spectroscopy, and magnetic susceptibility. The two latter techniques unequivocally demonstrate that [Fe(phtmeimb)(2)](PF6)(2)is a triplet Fe(IV)low-spinS=1 complex in the ground state, in agreement with quantum chemical calculations. The electronic absorption spectrum of [Fe(phtmeimb)(2)](PF6)(2)in acetonitrile shows an intense absorption band in the red and near IR, due to LMCT (ligand-to-metal charge transfer) excitation. For the first time the excited state dynamics of a Fe(IV)complex was studied and revealed a approximate to 0.8 ps lifetime of the(3)LMCT excited state of [Fe(phtmeimb)(2)](PF6)(2)in acetonitrile.
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| 18. |
- Prakash, Om, et al.
(författare)
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How Rigidity and Conjugation of Bidentate Ligands Affect the Geometry and Photophysics of Iron N-Heterocyclic Complexes : A Comparative Study
- 2024
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Ingår i: Inorganic Chemistry. - : American Chemical Society (ACS). - 0020-1669 .- 1520-510X. ; 63:10, s. 4461-4473
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Tidskriftsartikel (refereegranskat)abstract
- Two iron complexes featuring the bidentate, nonconjugated N-heterocyclic carbene (NHC) 1,1′-methylenebis(3-methylimidazol-2-ylidene) (mbmi) ligand, where the two NHC moieties are separated by a methylene bridge, have been synthesized to exploit the combined influence of geometric and electronic effects on the ground- and excited-state properties of homoleptic FeIII-hexa-NHC [Fe(mbmi)3](PF6)3 and heteroleptic FeII-tetra-NHC [Fe(mbmi)2(bpy)](PF6)2 (bpy = 2,2′-bipyridine) complexes. They are compared to the reported FeIII-hexa-NHC [Fe(btz)3](PF6)3 and FeII-tetra-NHC [Fe(btz)2(bpy)](PF6)2 complexes containing the conjugated, bidentate mesoionic NHC ligand 3,3′-dimethyl-1,1′-bis(p-tolyl)-4,4′-bis(1,2,3-triazol-5-ylidene) (btz). The observed geometries of [Fe(mbmi)3](PF6)3 and [Fe(mbmi)2(bpy)](PF6)2 are evaluated through L-Fe-L bond angles and ligand planarity and compared to those of [Fe(btz)3](PF6)3 and [Fe(btz)2(bpy)](PF6)2. The FeII/FeIII redox couples of [Fe(mbmi)3](PF6)3 (−0.38 V) and [Fe(mbmi)2(bpy)](PF6)2 (−0.057 V, both vs Fc+/0) are less reducing than [Fe(btz)3](PF6)3 and [Fe(btz)2(bpy)](PF6)2. The two complexes show intense absorption bands in the visible region: [Fe(mbmi)3](PF6)3 at 502 nm (ligand-to-metal charge transfer, 2LMCT) and [Fe(mbmi)2(bpy)](PF6)2 at 410 and 616 nm (metal-to-ligand charge transfer, 3MLCT). Lifetimes of 57.3 ps (2LMCT) for [Fe(mbmi)3](PF6)3 and 7.6 ps (3MLCT) for [Fe(mbmi)2(bpy)](PF6)2 were probed and are somewhat shorter than those for [Fe(btz)3](PF6)3 and [Fe(btz)2(bpy)](PF6)2. [Fe(mbmi)3](PF6)3 exhibits photoluminescence at 686 nm (2LMCT) in acetonitrile at room temperature with a quantum yield of (1.2 ± 0.1) × 10-4, compared to (3 ± 0.5)
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| 19. |
- Prakash, Om, et al.
(författare)
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Photophysical Integrity of the Iron(III) Scorpionate Framework in Iron(III)-NHC Complexes with Long-Lived 2LMCT Excited States
- 2022
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Ingår i: Inorganic Chemistry. - : American Chemical Society (ACS). - 0020-1669 .- 1520-510X. ; 61:44, s. 17515-17526
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Tidskriftsartikel (refereegranskat)abstract
- Fe(III) complexes with N-heterocyclic carbene (NHC) ligands belong to the rare examples of Earth-abundant transition metal complexes with long-lived luminescent charge-transfer excited states that enable applications as photosensitizers for charge separation reactions. We report three new hexa-NHC complexes of this class: [Fe(brphtmeimb)2]PF6 (brphtmeimb = [(4-bromophenyl)tris(3-methylimidazol-2-ylidene)borate]–, [Fe(meophtmeimb)2]PF6 (meophtmeimb = [(4-methoxyphenyl)tris(3-methylimidazol-2-ylidene)borate]–, and [Fe(coohphtmeimb)2]PF6 (coohphtmeimb = [(4-carboxyphenyl)tris(3-methylimidazol-2-ylidene)borate]–. These were derived from the parent complex [Fe(phtmeimb)2]PF6 (phtmeimb = [phenyltris(3-methylimidazol-2-ylidene)borate]– by modification with electron-withdrawing and electron-donating substituents, respectively, at the 4-phenyl position of the ligand framework. All three Fe(III) hexa-NHC complexes were characterized by NMR spectroscopy, high-resolution mass spectroscopy, elemental analysis, single crystal X-ray diffraction analysis, electrochemistry, Mößbauer spectroscopy, electronic spectroscopy, magnetic susceptibility measurements, and quantum chemical calculations. Their ligand-to-metal charge-transfer (2LMCT) excited states feature nanosecond lifetimes (1.6–1.7 ns) and sizable emission quantum yields (1.7–1.9%) through spin-allowed transition to the doublet ground state (2GS), completely in line with the parent complex [Fe(phtmeimb)2]PF6 (2.0 ns and 2.1%). The integrity of the favorable excited state characteristics upon substitution of the ligand framework demonstrates the robustness of the scorpionate motif that tolerates modifications in the 4-phenyl position for applications such as the attachment in molecular or hybrid assemblies.
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| 20. |
- Prakash, Om, et al.
(författare)
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Tailoring the Photophysical Properties of a Homoleptic Iron(II) Tetra N-Heterocyclic Carbene Complex by Attaching an Imidazolium Group to the (C∧N∧C) Pincer Ligand─A Comparative Study
- 2024
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Ingår i: Inorganic Chemistry. - : American Chemical Society (ACS). - 0020-1669 .- 1520-510X. ; 63:6, s. 2909-2918
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Tidskriftsartikel (refereegranskat)abstract
- We here report the synthesis of the homoleptic iron(II) N-heterocyclic carbene (NHC) complex [Fe(miHpbmi)2](PF6)4 (miHpbmi = 4-((3-methyl-1H-imidazolium-1-yl)pyridine-2,6-diyl)bis(3-methylimidazol-2-ylidene)) and its electrochemical and photophysical properties. The introduction of the π-electron-withdrawing 3-methyl-1H-imidazol-3-ium-1-yl group into the NHC ligand framework resulted in stabilization of the metal-to-ligand charge transfer (MLCT) state and destabilization of the metal-centered (MC) states. This resulted in an improved excited-state lifetime of 16 ps compared to the 9 ps for the unsubstituted parent compound [Fe(pbmi)2](PF6)2 (pbmi = (pyridine-2,6-diyl)bis(3-methylimidazol-2-ylidene)) as well as a stronger MLCT absorption band extending more toward the red spectral region. However, compared to the carboxylic acid derivative [Fe(cpbmi)2](PF6)2 (cpbmi = 1,1′-(4-carboxypyridine-2,6-diyl)bis(3-methylimidazol-2-ylidene)), the excited-state lifetime of [Fe(miHpbmi)2](PF6)4 is the same, but both the extinction and the red shift are more pronounced for the former. Hence, this makes [Fe(miHpbmi)2](PF6)4 a promising pH-insensitive analogue of [Fe(cpbmi)2](PF6)2. Finally, the excited-state dynamics of the title compound [Fe(miHpbmi)2](PF6)4 was investigated in solvents with different viscosities, however, showing very little dependency of the depopulation of the excited states on the properties of the solvent used.
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| 21. |
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| 22. |
- Strand, Lennart
(författare)
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An interview with Rune Pettersson
- 2008
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Ingår i: Information Design Journal. - Amsterdam : John Benjamins Publishing Company. - 0142-5471 .- 1569-979X. ; 16:3, s. 229-234
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Tidskriftsartikel (refereegranskat)abstract
- In May 1999 Rune Pettersson, Ph.D, was appointedProfessor of Information Design at Mälardalen University in Eskilstuna, Sweden. Before that he worked in publishing, in R&D, in technical training and in university teaching and research. He has published 218 papers and 75 books. Among his books is Information Design: An Introduction (John Benjamins, 2002).Rune Pettersson has been active in several international organisations, such as Vice President of the International Visual Literacy Association, IVLA (six times), and President during 2000–2001; and Vice President of the International Institute for Information Design, IIID, 2000–2006. He has also been an International Advisor for the International Division of the Association for Educational Communications and Technology, as well as a board member in several other organisations. For nine years (1987–1996) Rune Pettersson was an Affiliate Research Professor of the Institute of Business Graphics at the College of Business Administration, Pennsylvania State University in the USA. For five years (2000–2004) he was an Adjunct Professor at Appalachian State University, Department of Curriculum and Instruction, in the USA.
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| 23. |
- Strand, Lennart
(författare)
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idX – Information Design Exchange. What information designers know and can do
- 2007
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Strand, Lennart (2007). Co-author: idX – Information Design Exchange. What information designers know and can do. "Development of International Core Competencies and Student and Faculty Exchange in Information Design" within the EU/US Cooperation Programme in Higher Education and Vocational Education and Training Outcome. Developed in co-operation with International Institute for Information Design, http://www.iiid.net/
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| 24. |
- Strand, Lennart, 1942-
(författare)
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Legibility on a Podcast: Color and typefaces
- 2008
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Ingår i: Proceedings of the 2007 International Conference on Systems, Computing Sciences and Software Engineering (SCSS), part of the International Joint Conferences on Computer, Information, and Systems Sciences, and Engineering (CISSE 2007). - Dordrecht : Springer. - 9781402087400 ; , s. 265-267
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Konferensbidrag (refereegranskat)abstract
- Abstract–As in printed matter, black text on white background is the most legible color combination on small computer screens like media players.
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| 25. |
- Strand, Sven-Erik, et al.
(författare)
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Applications and characterization of radiolabeled or magnetizable nano- and microparticles for res, lymph, and blood flow studies
- 2017
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Ingår i: Microspheres : Medical and Biological Applications - Medical and Biological Applications. - : CRC Press. - 9781138506206 - 9781351360067 ; , s. 193-227
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Bokkapitel (refereegranskat)abstract
- For diagnostic purpose, particles can be labeled with radionuclides or contain magnetizable materials making them suitable for external measurements of their biokinetics in vivo. In therapy, particles can be used as targetable drug-delivery systems or, if containing radioactivity, for internal radiation therapy. Loaded with, e.g., stable iodine, particles may also be used for photon activation therapy.
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| 26. |
- Söderlund Strand, Anna, et al.
(författare)
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Human papillomavirus type-specific persistence and recurrence after treatment for cervical dysplasia
- 2014
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Ingår i: Journal of Medical Virology. - : Wiley-Blackwell. - 0146-6615 .- 1096-9071. ; 86:4, s. 634-641
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Tidskriftsartikel (refereegranskat)abstract
- Human papillomavirus (HPV) infection is a necessary factor in the cervical cancer development. Also after treatment for cervical dysplasia, HPV can be present and promote the recurrence of cervical disease. In the present study, the aim was to perform a long-term follow-up on the ability of HPV testing with genotyping, as compared with cytology, to predict recurrence of high-grade cervical intraepithelial neoplasia and to evaluate the effectiveness of treatment with loop electrosurgical excision procedure (LEEP) conization. Cervical samples for HPV DNA testing and cytological analysis were obtained from 178 women with abnormal smears referred for treatment with LEEP conization. These women were scheduled for HPV DNA testing and Pap smears before and 3, 6, 12, 24, and 36 months after treatment. Three years after treatment 3.1% (N = 4) of women were still persistently HPV-positive with the same type as had been detected at treatment. Recurrent or residual cervical intraepithelial neoplasia II+ in histopathology was found among 9 (5.1%) women during follow-up. All of these women had type-specific HPV-persistence (sensitivity 100% [95% CI 63-100%] and specificity 94.7% [89.8-97.4%]), but only 7/9 had abnormal cytology (sensitivity 77.8% [40.2-96.1%] and specificity 94.7% [89.8-97.4%]). No recurrent or residual disease was found among women with any other patterns of HPV positivity (e.g., type change or fluctuating positivity) (sensitivity 0% [95% CI 0-37.1%] and specificity 80.5% [73.5-86.0%]). In conclusion, only type-specific HPV persistence predicted recurrent or residual disease, and HPV genotyping appears useful to improve the specificity when using HPV testing in post-treatment follow-up. J. Med. Virol. 86:634-641, 2014.
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| 27. |
- Tirado-Gonzalez, Irene, et al.
(författare)
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Galectin-1 influences trophoblast immune evasion and emerges as a predictive factor for the outcome of pregnancy
- 2013
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Ingår i: Molecular human reproduction. - : Oxford University Press (OUP). - 1360-9947 .- 1460-2407. ; 19:1, s. 43-53
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Tidskriftsartikel (refereegranskat)abstract
- Galectin-1 (gal-1) is expressed at the feto-maternal interface and plays a role in regulating the maternal immune response against placental alloantigens, contributing to pregnancy maintenance. Both decidua and placenta contribute to gal-1 expression and may be important for the maternal immune regulation. The expression of gal-1 within the placenta is considered relevant to cell-adhesion and invasion of trophoblasts, but the role of gal-1 in the immune evasion machinery exhibited by trophoblast cells remains to be elucidated. In this study, we analyzed gal-1 expression in preimplantation human embryos and first-trimester decidua-placenta specimens and serum gal-1 levels to investigate the physiological role played by this lectin during pregnancy. The effect on human leukocyte antigen G (HLA-G) expression in response to stimulation or silencing of gal-1 was also determined in the human invasive, proliferative extravillous cytotrophoblast 65 (HIPEC65) cell line. Compared with normal pregnant women, circulating gal-1 levels were significantly decreased in patients who subsequently suffered a miscarriage. Human embryos undergoing preimplantation development expressed gal-1 on the trophectoderm and inner cell mass. Furthermore, our in vitro experiments showed that exogenous gal-1 positively regulated the membrane-bound HLA-G isoforms (HLA-G1 and G2) in HIPEC65 cells, whereas endogenous gal-1 also induced expression of the soluble isoforms (HLA-G5 and -G6). Our results suggest that gal-1 plays a key role in pregnancy maternal immune regulation by modulating HLA-G expression on trophoblast cells. Circulating gal-1 levels could serve as a predictive factor for pregnancy success in early human gestation.
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