| 1. |
- Ali, Aamir, 1994, et al.
(författare)
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Engineering Symmetry-Selective Couplings of a Superconducting Artificial Molecule to Microwave Waveguides
- 2022
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Ingår i: Physical Review Letters. - 1079-7114 .- 0031-9007. ; 129:12
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Tidskriftsartikel (refereegranskat)abstract
- Tailoring the decay rate of structured quantum emitters into their environment opens new avenues for nonlinear quantum optics, collective phenomena, and quantum communications. Here, we demonstrate a novel coupling scheme between an artificial molecule comprising two identical, strongly coupled transmon qubits and two microwave waveguides. In our scheme, the coupling is engineered so that transitions between states of the same (opposite) symmetry, with respect to the permutation operator, are predominantly coupled to one (the other) waveguide. The symmetry-based coupling selectivity, as quantified by the ratio of the coupling strengths, exceeds a factor of 30 for both waveguides in our device. In addition, we implement a Raman process activated by simultaneously driving both waveguides, and show that it can be used to coherently couple states of different symmetry in the single-excitation manifold of the molecule. Using that process, we implement frequency conversion across the waveguides, mediated by the molecule, with efficiency of about 95%. Finally, we show that this coupling arrangement makes it possible to straightforwardly generate spatially separated Bell states propagating across the waveguides. We envisage further applications to quantum thermodynamics, microwave photodetection, and photon-photon gates.
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| 2. |
- Druid, Henrik, et al.
(författare)
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Evaluation of the role of abstinence in heroin overdose deaths using segmental hair analysis
- 2007
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Ingår i: Forensic Science International. - : Elsevier BV. - 0379-0738 .- 1872-6283. ; 168:2-3, s. 223-226
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Tidskriftsartikel (refereegranskat)abstract
- In the body heroin is rapidly metabolized to 6-acetylmorphine and morphine. Victims of lethal heroin overdose often present with fairly low blood concentrations of morphine. Reduced tolerance due to abstinence has been proposed to account for this finding. The aim of the present study was to examine the role of abstinence in drug-related deaths by comparing recent and past exposure to opioids using segmental hair analysis with the postmortem blood morphine concentrations in deceased heroin users. The study included 60 deceased drug addicts in the Stockholm area, Sweden. In 32 cases, death was not related to heroin intake. In 18 of the 28 heroin fatalities, opioids were absent in the most recent hair segment, suggesting a reduced tolerance to opioids. However, the blood morphine levels were similar to those found in the 10 subjects that showed continuous opioid use. Hair and blood analysis disclosed an extensive use of additional drugs that directly or indirectly may influence the opioid system. The results suggest that abstinence is not a critical factor for heroin overdose death. Obviously tolerant subjects die after intake of similar doses. Other factors, particularly polydrug use, seem to be more causally important for these deaths.
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| 3. |
- Elsik, Christine G., et al.
(författare)
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The Genome Sequence of Taurine Cattle : A Window to Ruminant Biology and Evolution
- 2009
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 324:5926, s. 522-528
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Tidskriftsartikel (refereegranskat)abstract
- To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.
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| 4. |
- Henriksson, Anna, et al.
(författare)
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Does inflammation markers or treatment type moderate exercise intensity effects on changes in muscle strength in cancer survivors participating in a 6-month combined resistance- and endurance exercise program? : Results from the Phys-Can trial
- 2023
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Ingår i: BMC Sports Science, Medicine and Rehabilitation. - : BioMed Central (BMC). - 2052-1847. ; 15:1
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Resistance exercise has a beneficial impact on physical function for patients receiving oncological treatment. However, there is an inter-individual variation in the response to exercise and the tolerability to high-intensity exercise. Identifying potential moderating factors, such as inflammation and treatment type, for changes in muscle strength is important to improve the effectiveness of exercise programs. Therefore, we aimed to investigate if inflammation and type of oncological treatment moderate the effects of exercise intensity (high vs. low-moderate) on muscular strength changes in patients with breast (BRCA) or prostate cancer (PRCA).METHODS: Participants with BRCA (n = 286) and PRCA (n = 65) from the Physical training and Cancer study (Phys-Can) were included in the present study. Participants performed a combined resistance- and endurance exercise program during six months, at either high or low-moderate intensity. Separate regression models were estimated for each cancer type, with and without interaction terms. Moderators included in the models were treatment type (i.e., neo/adjuvant chemotherapy-yes/no for BRCA, adjuvant androgen deprivation therapy (ADT)-yes/no for PRCA)), and inflammation (interleukin 6 (IL6) and tumor necrosis factor-alpha (TNFα)) at follow-up.RESULTS: For BRCA, neither IL6 (b = 2.469, 95% CI [- 7.614, 12.552]) nor TNFα (b = 0.036, 95% CI [- 6.345, 6.418]) levels moderated the effect of exercise intensity on muscle strength change. The same was observed for chemotherapy treatment (b = 4.893, 95% CI [- 2.938, 12.724]). Similarly, for PRCA, the effect of exercise intensity on muscle strength change was not moderated by IL6 (b = - 1.423, 95% CI [- 17.894, 15.048]) and TNFα (b = - 1.905, 95% CI [- 8.542, 4.732]) levels, nor by ADT (b = - 0.180, 95% CI [- 11.201, 10.841]).CONCLUSIONS: The effect of exercise intensity on muscle strength is not moderated by TNFα, IL6, neo/adjuvant chemotherapy, or ADT, and therefore cannot explain any intra-variation of training response regarding exercise intensity (e.g., strength gain) for BRCA or PRCA in this setting.TRIAL REGISTRATION: ClinicalTrials.gov NCT02473003.
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| 5. |
- Jolin, Shan Williams, et al.
(författare)
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Multipartite entanglement in a microwave frequency comb
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Significant progress has been made with multipartite entanglement of discrete qubits, but continuous variable systems may provide a more scalable path toward entanglement of large ensembles. We demonstrate multipartite entanglement in a microwave frequency comb generated by a Josephson parametric amplifier subject to a bichromatic pump. We find 64 correlated modes in the transmission line using a multifrequency digital signal processing platform. Full inseparability is verified in a subset of seven modes. Our method can be expanded to generate even more entangled modes in the near future.
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| 6. |
- Jolin, Shan Williams, et al.
(författare)
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Multipartite Entanglement in a Microwave Frequency Comb
- 2023
-
Ingår i: Physical Review Letters. - : American Physical Society (APS). - 0031-9007 .- 1079-7114. ; 130:12
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Tidskriftsartikel (refereegranskat)abstract
- Significant progress has been made with multipartite entanglement of discrete qubits, but continuous variable systems may provide a more scalable path toward entanglement of large ensembles. We demonstrate multipartite entanglement in a microwave frequency comb generated by a Josephson parametric amplifier subject to a bichromatic pump. We find 64 correlated modes in the transmission line using a multifrequency digital signal processing platform. Full inseparability is verified in a subset of seven modes. Our method can be expanded to generate even more entangled modes in the near future.
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| 7. |
- Kronstrand, Robert, et al.
(författare)
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Screening for drugs of abuse in hair with ion spray LC-MS-MS
- 2004
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Ingår i: Forensic Science International. - : Elsevier BV. - 0379-0738 .- 1872-6283. ; 145:02-Mar, s. 183-190
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Tidskriftsartikel (refereegranskat)abstract
- Analyzing hair for many substances can be tedious and expensive, and a rapid screening method should prove helpful. Generally, screening has been performed using immunological tests, mainly in workplace drug testing, where the number of samples has been high. The aim of this study was to develop an LC-MS-MS method for the simultaneous analysis of several drugs of abuse in human hair as an alternative to immunological screening tests. In 75 randomly selected autopsy cases, hair was analyzed in addition to the usual specimens of blood and urine. The method included nicotine, cotinine, morphine, codeine, 6-acetylmorphine, ethylmorphine, amphetamine, methamphetamine, MDA, MDMA, benzoylecgonine, cocaine, 7-aminoflunitrazepam and diazepam. The LC-MS-MS analysis was performed on a SCIEX API 2000 MS-MS instrument equipped with an electrospray interface. To 20-50 mg of hair, 0.5 ml of mobile phase A (acetonitril:methanol: 20 mM formate buffer, pH 3.0 (10:10:80)) and 25 mul of internal standard were added and the sample was incubated in a water bath at 37degreesC during 18 h. Using a threshold of 20 ng/ sample, equivalent to 1 ng/mg if 20 mg hair is used, 26 positive results were found in 16 cases. Three of the 26 positive detections could not be confirmed by GC-MS. Two of the cases were not previously known as drug users. Of the 59 negative cases, only one case had a positive blood sample showing 0.01 and 0.07 mug/g femoral blood of 6-acetylmorphine and morphine, respectively. This might indicate drug abstinence resulting in decreased tolerance or even a "first time" use of heroin resulting in death. We conclude that the use of hair analysis in postmortem cases can reveal both unknown drug use, as well as confirm a period of drug abstinence prior to an acute fatal overdose. The proposed LC-MS-MS method showed high sensitivity, was very easy to perform and seemed appropriate for screening purposes.
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| 8. |
- Kudra, Marina, 1992, et al.
(författare)
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Robust Preparation of Wigner-Negative States with Optimized SNAP-Displacement Sequences
- 2022
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Ingår i: PRX Quantum. - : AMER PHYSICAL SOC. - 2691-3399. ; 3:3
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Tidskriftsartikel (refereegranskat)abstract
- Hosting nonclassical states of light in three-dimensional microwave cavities has emerged as a promising paradigm for continuous-variable quantum information processing. Here we experimentally demonstrate high-fidelity generation of a range of Wigner-negative states useful for quantum computation, such as Schrodinger-cat states, binomial states, Gottesman-Kitaev-Preskill states, as well as cubic phase states. The latter states have been long sought after in quantum optics and have never been achieved experimentally before. We use a sequence of interleaved selective number-dependent arbitrary phase (SNAP) gates and displacements. We optimize the state preparation in two steps. First we use a gradient-descent algorithm to optimize the parameters of the SNAP and displacement gates. Then we optimize the envelope of the pulses implementing the SNAP gates. Our results show that this way of creating highly nonclassical states in a harmonic oscillator is robust to fluctuations of the system parameters such as the qubit frequency and the dispersive shift.
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| 9. |
- Kölbel, Tilo, et al.
(författare)
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Activated protein C-protein C inhibitor complex: a new biological marker for aortic aneurysms.
- 2006
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Ingår i: Journal of Vascular Surgery. - : Elsevier BV. - 1097-6809 .- 0741-5214. ; 43:5, s. 935-939
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Tidskriftsartikel (refereegranskat)abstract
- Objective: The concentration of the complex between activated protein C (APC) and protein C inhibitor (PCI) is a measure of thrombin generation. We studied whether it can provide information useful for the diagnosis and treatment of arterial vascular disease. Methods: Blood was obtained from 429 vascular patients admitted consecutively during September 2004 to March 2005. The APC-PCI complex was measured by using a sandwich immunofluorometric method. The patients were divided into cohorts according to the planned treatment and compared with a control group of healthy individuals. Results: The APC-PCI complex concentration varied from 0.08 to 2.50 mu g/L. In the cohort of patients with aortic aneurysms (n = 78), the median APC-PCI value was 0.45 (10(th) to 90(th) percentile, 0.24-1.47), and values were clearly increased compared with all other cohorts (P <.0001). Patients with carotid disease (n = 73) yielded a median of 0.22 (10(th) to 90(th) percentile, 0.15-0.48). The median for claudicants (n = 74) was 0.26 mu g/L (10(th) to 90(th) percentile, 0.15-0.75), which was higher than in those (n = 97) with critical ischemia (0.20; 10(th) to 90(th) percentile, 0.13-0.36; P <.0023). The cohort with other forms of antherosclerotic disease (n = 40) had a median of 0.23 (10(th) to 90(th) percentile, 0.14-0.42), whereas the value for a cohort of 21 patients with venous disease was 0.19 (10(th) to 90(th) percentile, 0.10-0.34). The median was 0.15 (10(th) to 90(th) percentile, 0.10-0.23) for the control group (n = 121). Conclusions: Patients with atherosclerosis had an increased APC-PCI concentration that corresponded to increased generation of thrombin. Patients with aortic aneurysm had a threefold higher median concentration than the control group. We suggest that this remarkable increase is caused by the local activation of coagulation, and we surmise that APC-PCI measurements can be used as a screening tool to identify patients with aortic aneurysms.
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| 10. |
- Kölbel, Tilo, et al.
(författare)
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Activated Protein C Protein C Inhibitor Complex in Patients With Abdominal Aortic Aneurysms: Is It Associated With Diameter and Growth Rate?
- 2008
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Ingår i: Vascular and Endovascular Surgery. - : SAGE Publications. - 1938-9116 .- 1538-5744. ; 42:2, s. 135-140
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Tidskriftsartikel (refereegranskat)abstract
- Increased thrombin activation has been documented in patients with abdominal aortic aneurysm (AAA). APC-PCI complex, a new biological marker of thrombin generation, was measured in a population of 232 patients with AAA relative and a control group and the association between aneurysm size, growth rate and APC-PCI was studied. The patients were divided into cohorts according to the AAA diameter and compared with a control group. APC-PCI was significantly higher in all AAA-cohorts (n = 232; median: 0.36 mg/L; 10th - 90th percentile: 0.18-1.01) compared to the control group (n = 41; median: 0.19 mg/L; 10th - 90th percentile: 0.11-0.31; P = <0.001). APC-PCI correlated with the AAA diameter (r = 0.22, P = 0.001), with the BMI (r = -0.19, P = 0.004) and with age (r = 0.19, P = 0.004). APC-PCI did not correlate with the AAA-growth rate (r = 0.11, P = 0.14).
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| 11. |
- Lu, Yong, 1989, et al.
(författare)
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Propagating Wigner-Negative States Generated from the Steady-State Emission of a Superconducting Qubit
- 2021
-
Ingår i: Physical Review Letters. - 1079-7114 .- 0031-9007. ; 126:25
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Tidskriftsartikel (refereegranskat)abstract
- We experimentally demonstrate the steady-state generation of propagating Wigner-negative states from a continuously driven superconducting qubit. We reconstruct the Wigner function of the radiation emitted into propagating modes defined by their temporal envelopes, using digital filtering. For an optimized temporal filter, we observe a large Wigner logarithmic negativity, in excess of 0.08, in agreement with theory. The fidelity between the theoretical predictions and the states generated experimentally is up to 99%, reaching state-of-the-art realizations in the microwave frequency domain. Our results provide a new way to generate and control nonclassical states, and may enable promising applications such as quantum networks and quantum computation based on waveguide quantum electrodynamics.
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| 12. |
- Matérne, Marie, 1967-, et al.
(författare)
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Hälso- och sjukvårdskuratorns funktion i rehabilitering för personer med stroke
- 2022
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Ingår i: Socialmedicinsk Tidskrift. - : Socialmedicinsk tidskrift. - 0037-833X .- 2000-4192. ; 99:1, s. 76-86
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Tidskriftsartikel (refereegranskat)abstract
- Att stödja patienter i rehabilitering efter stroke är en viktig funktion för hälso- och sjukvårdskuratorn. I denna artikel analyseras hälso- och sjukvårdskuratorns funktion utifrån ett systemteoretiskt perspektiv med stöd av patienternas erfarenheter av resiliens och livskvalitet. Intervjuer med 19 personer med stroke sekundäranalyserades tematiskt och resulterade i fem områden av betydelse för hälso- och sjukvårdskuratorns funktion. De teman som framkom på mikronivå var: trygghet och förutsägbarhet; mening och hopp. På mesonivå: socialt och formellt stöd; samordna och informera. På makronivå: kunskapsspridning och kompetens. Den legitimerade hälso- och sjukvårdskuratorn funktioner återfinns således systemteoretiskt på alla nivåer vilket innebär att de professionellt antar en helhetssyn med fokus på individen i relation till dennes situation och kontext.
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| 13. |
- Mazzoni, Anne-Sophie, et al.
(författare)
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Reallocating sedentary time to physical activity : effects on fatigue and quality of life in patients with breast cancer in the Phys-Can project
- 2023
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Ingår i: Supportive Care in Cancer. - : Springer Nature. - 0941-4355 .- 1433-7339. ; 31:2
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: We aimed to investigate the effects of reallocating sedentary time to an equal amount of light (LPA) or moderate-to-vigorous intensity physical activity (MVPA) on cancer-related fatigue and health-related quality of life (HRQoL) in patients with breast cancer. We also aimed to determine the daily amount of sedentary time needed to be reallocated to LPA or MVPA to produce minimal clinically important changes in these outcomes.METHODS: Pooled baseline data from three studies were used, including women with breast cancer who participated in the Phys-Can project. Fatigue was assessed with the Multidimensional Fatigue Inventory questionnaire (MFI; five dimensions, 4-20 scale) and HRQoL with the European Organisation for Research and Treatment of Cancer quality of life questionnaire (EORTC QLQ-C30; 0-100 scale). Sedentary time and physical activity were measured with accelerometry. Isotemporal substitution modelling was used for the analyses.RESULTS: Overall, 436 participants (mean age 56 years, fatigue 11 [MFI], HRQoL 66 [EORTC QLQ-C30], LPA 254 min/day, MVPA 71 min/day) were included. Fatigue significantly decreased in two MFI dimensions when reallocating 30 min/day of sedentary time to LPA: reduced motivation and reduced activity (β = - 0.21). Fatigue significantly decreased in three MFI dimensions when reallocating 30 min/day of sedentary time to MVPA: general fatigue (β = - 0.34), physical fatigue (β = - 0.47) and reduced activity (β = - 0.48). To produce minimal clinically important changes in fatigue (- 2 points on MFI), the amount of sedentary time needed to be reallocated to LPA was ≈290 min/day and to MVPA was ≥ 125 min/day. No significant effects were observed on HRQoL when reallocating sedentary time to LPA or MVPA.CONCLUSIONS: Our results suggest that reallocating sedentary time to LPA or MVPA has beneficial effects on cancer-related fatigue in patients with breast cancer, with MVPA having the greatest impact. In relatively healthy and physically active breast cancer populations, a large amount of time reallocation is needed to produce clinically important changes. Future studies are warranted to evaluate such effects in broader cancer populations.TRIAL REGISTRATION: NCT02473003 (10/10/2014) and NCT04586517 (14/10/2020).
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| 14. |
- Quijandria Diaz, Isaac Fernando, 1982, et al.
(författare)
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Steady-State Generation of Wigner-Negative States in One-Dimensional Resonance Fluorescence
- 2018
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Ingår i: Physical Review Letters. - 1079-7114 .- 0031-9007. ; 121:26
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Tidskriftsartikel (refereegranskat)abstract
- In this work we demonstrate numerically that the nonlinearity provided by a continuously driven two-level system allows for the generation of Wigner-negative states of the electromagnetic field confined in one spatial dimension. Wigner-negative states, also known as Wigner nonclassical states, are desirable for quantum information protocols beyond the scope of classical computers. Focusing on the steady-state emission from the two-level system, we find the largest negativity at the drive strength where the coherent reflection vanishes.
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| 15. |
- Schauer, Tim, et al.
(författare)
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Pre-treatment levels of inflammatory markers and chemotherapy completion rates in patients with early-stage breast cancer
- 2023
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Ingår i: International Journal of Clinical Oncology. - : Springer Nature. - 1341-9625 .- 1437-7772. ; 28:1, s. 89-98
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Chemotherapy efficacy is largely dependent on treatment adherence, defined by the relative dose intensity (RDI). Identification of new modifiable risk factors associated with low RDI might improve chemotherapy delivery. Here, we evaluated the association between low RDI and pre-chemotherapy factors, including patient- and treatment-related characteristics and markers of inflammation.METHODS: This exploratory analysis assessed data from 267 patients with early-stage breast cancer scheduled to undergo (neo-)adjuvant chemotherapy included in the Physical training and Cancer (Phys-Can) trial. The association between low RDI, defined as < 85%, patient-related (age, body mass index, co-morbid condition, body surface area) and treatment-related factors (cancer stage, receptor status, chemotherapy duration, chemotherapy dose, granulocyte colony-stimulating factor) was investigated. Analyses further included the association between RDI and pre-chemotherapy levels of interleukin (IL)-6, IL-8, IL-10, C-reactive protein (CRP) and Tumor Necrosis Factor-alpha (TNF-α) in 172 patients with available blood samples.RESULTS: An RDI of < 85% occurred in 31 patients (12%). Univariable analysis revealed a significant association with a chemotherapy duration above 20 weeks (p < 0.001), chemotherapy dose (p = 0.006), pre-chemotherapy IL-8 (OR 1.61; 95% CI (1.01; 2.58); p = 0.040) and TNF-α (OR 2.2 (1.17; 4.53); p = 0.019). In multivariable analyses, inflammatory cytokines were significant association with low RDI for IL-8 (OR: 1.65 [0.99; 2.69]; p = 0.044) and TNF-α (OR 2.95 [1.41; 7.19]; p = 0.007).CONCLUSIONS: This exploratory analysis highlights the association of pre-chemotherapy IL-8 and TNF-α with low RDI of chemotherapy for breast cancer. IL-8 and TNF-α may therefore potentially help to identify patients at risk for experiencing dose reductions. Clinical trial number NCT02473003 (registration: June 16, 2015).
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| 16. |
- Strandberg, Emelie, et al.
(författare)
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Effects of heavy-load resistance training during (neo-)adjuvant chemotherapy on muscle cellular outcomes in women with breast cancer
- 2021
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Ingår i: Medicine. - 0025-7974 .- 1536-5964. ; 100:10
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: (Neo-)adjuvant chemotherapy for breast cancer has a deleterious impact on muscle tissue resulting in reduced cardiorespiratory fitness, skeletal muscle mass and function. Physical exercise during treatment may counteract some of these negative effects. However, the effects of resistance training (RT) alone have never been explored. The present study aims to investigate if heavy-load RT during (neo-)adjuvant chemotherapy counteracts deleterious effects on skeletal muscle in women diagnosed with breast cancer. We hypothesize that (neo-)adjuvant treatment with chemotherapy will reduce muscle fiber size, impair mitochondrial function, and increase indicators of cellular stress and that RT during treatment will counteract these negative effects. We also hypothesize that RT during (neo-)adjuvant chemotherapy will increase muscle and blood levels of potential antitumor myokines and reduce treatment-related side effects on muscle strength and cardiorespiratory fitness.Methods: Fifty women recently diagnosed with breast cancer scheduled to start (neo-)adjuvant chemotherapy will be randomized to either randomized to either intervention group or to control group.The intervention group will perform supervised heavy-load RT twice a week over the course of chemotherapy (approximately 16-weeks) whereas the control group will be encouraged to continue with their usual activities. Muscle biopsies from m. vastus lateralis will be collected before the first cycle of chemotherapy (T0), after chemotherapy (T1), and 6 months later (T2) for assessment of muscle cellular outcomes. The primary outcome for this study is muscle fiber size. Secondary outcomes are: regulators of muscle fiber size and function, indicators of cellular stress and mitochondrial function, myokines with potential antitumor effects, muscle strength, and cardiorespiratory fitness.Ethics and dissemination: Ethical approval has been obtained from the Regional Ethical Review Board in Uppsala, Sweden (Dnr:2016/230/2). Results will be disseminated through presentations at scientific meetings, publications in peer-reviewed journals, social media, and patient organizations.Trial registration number: NCT04586517.
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| 17. |
- Strandberg, Emelie, et al.
(författare)
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Who makes it all the way? : Participants vs. decliners, and completers vs. drop-outs, in a 6-month exercise trial during cancer treatment. Results from the Phys-Can RCT
- 2022
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Ingår i: Supportive Care in Cancer. - : Springer Nature. - 0941-4355 .- 1433-7339. ; 30:2, s. 1739-1748
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Tidskriftsartikel (refereegranskat)abstract
- Purpose To compare sociodemographic, health- and exercise-related characteristics of participants vs. decliners, and completers vs. drop-outs, in an exercise intervention trial during cancer treatment.Methods Patients with newly diagnosed breast, prostate, or colorectal cancer were invited to participate in a 6-month exercise intervention. Background data for all respondents (n = 2051) were collected at baseline by questionnaire and medical records. Additional data were collected using an extended questionnaire, physical activity monitors, and fitness testing for trial participants (n = 577). Moreover, a sub-group of decliners (n = 436) consented to additional data collection by an extended questionnaire . Data were analyzed for between-group differences using independent t-tests and chi2-tests.Results Trial participants were younger (59 ± 12yrs vs. 64 ± 11yrs, p < .001), more likely to be women (80% vs. 75%, p = .012), and scheduled for chemotherapy treatment (54% vs. 34%, p < .001), compared to decliners (n = 1391). A greater proportion had university education (60% vs 40%, p < .001), reported higher anxiety and fatigue, higher exercise self-efficacy and outcome expectations, and less kinesiophobia at baseline compared to decliners. A greater proportion of trial participants were classified as ‘not physically active’ at baseline; however, within the group who participated, being “physically active” at baseline was associated with trial completion. Completers (n = 410) also reported less kinesiophobia than drop-outs (n = 167).Conclusion The recruitment procedures used in comprehensive oncology exercise trials should specifically address barriers for participation among men, patients without university education and older patients. Individualized efforts should be made to enroll patients with low exercise self-efficacy and low outcome expectations of exercise. To retain participants in an ongoing exercise intervention, extra support may be needed for patients with kinesiophobia and those lacking health-enhancing exercise habits at baseline.
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| 18. |
- Strandberg, Ingrid, 1990, et al.
(författare)
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Digital Homodyne and Heterodyne Detection for Stationary Bosonic Modes
- 2024
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Ingår i: Physical Review Letters. - 1079-7114 .- 0031-9007. ; 133:6
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Tidskriftsartikel (refereegranskat)abstract
- Homo- and heterodyne detection are fundamental techniques for measuring propagating electromagnetic fields. However, applying these techniques to stationary fields confined in cavities poses a challenge. As a way to overcome this challenge, we propose to use repeated indirect measurements of a two-level system interacting with the cavity. We demonstrate numerically that the proposed measurement scheme faithfully reproduces measurement statistics of homo- or heterodyne detection. The scheme can be implemented in various physical architectures, including circuit quantum electrodynamics. Our results pave the way for implementation of quantum algorithms requiring linear detection of stationary modes, including quantum verification protocols.
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| 19. |
- Strandberg, Ingrid, 1990
(författare)
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Generation and characterization of microwave quantum states
- 2022
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Quantum mechanics is the branch of physics that describes the properties and behavior of systems on the atomic and subatomic level. Over the past decades there has also been considerable progress in engineering larger-scale quantum systems. In this day and age, quantum information and quantum technology are rapidly developing areas of research where quantum effects are harnessed to improve sensitivity in measurements, encrypt secure communications, and enhance the performance of information processing and computing. Specific types of quantum states are needed for these purposes, and they can be challenging to generate in practice. This thesis describes methods to generate and characterize microwave states that could be useful for quantum computing protocols based on quantum states of light.
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| 20. |
- Strandberg, Ingrid, 1990, et al.
(författare)
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Numerical study of Wigner negativity in one-dimensional steady-state resonance fluorescence
- 2019
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Ingår i: Physical Review A - Atomic, Molecular, and Optical Physics. - 2469-9926 .- 2469-9934. ; 100:6
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Tidskriftsartikel (refereegranskat)abstract
- In a numerical study, we investigate the steady-state generation of nonclassical states of light from a coherently driven two-level atom in a one-dimensional waveguide. Specifically, we look for states with a negative Wigner function, since such nonclassical states are a resource for quantum information processing applications, including quantum computing. We find that a waveguide terminated by a mirror at the position of the atom can provide Wigner-negative states, while an infinite waveguide yields strictly positive Wigner functions. Moreover, our paper reveals a connection between the purity of a quantum state and its Wigner negativity. We also analyze the effects of decoherence on the negativity of a state.
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| 21. |
- Strandberg, Ingrid, 1990
(författare)
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Realistic prospect for continuous variable quantum computing in circuit-QED
- 2019
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This licentiate thesis is an extended introduction to the appended papers, which pertain to finding quantum states that are useful for continuous variable quantum computing. The useful states are characterized by a negative Wigner function. This is the underlying motivation for the appended papers, but why a negative Wigner function is necessary is not explained in the papers. This is elucidated in this thesis, with an accompanying discussion of which quantum mechanical properties allow quantum computers to surpass the capabilities of classical computers.
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| 22. |
- Strandberg, Ingrid, 1990
(författare)
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Simple, Reliable, and Noise-Resilient Continuous-Variable Quantum State Tomography with Convex Optimization
- 2022
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Ingår i: Physical Review Applied. - 2331-7019. ; 18:4
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Tidskriftsartikel (refereegranskat)abstract
- Precise reconstruction of unknown quantum states from measurement data, a process commonly called quantum state tomography, is a crucial component in the development of quantum informa-tion processing technologies. Many different tomography methods have been proposed over the years. Maximum-likelihood estimation is a prominent example, being the most popular method for a long period of time. Recently, more advanced neural-network methods have started to emerge. Here, we go back to basics and present a method for continuous-variable state reconstruction that is both conceptually and prac-tically simple, based on convex optimization. Convex optimization has been used for process tomography and qubit-state tomography, but seems to have been overlooked for continuous-variable quantum-state tomography. We demonstrate high-fidelity reconstruction of an underlying state from data corrupted by thermal noise and imperfect detection, for both homodyne and heterodyne measurements. A major advan-tage over other methods is that convex optimization algorithms are guaranteed to converge to the optimal solution.
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| 23. |
- Strandberg, Ingrid, 1990, et al.
(författare)
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Wigner negativity in the steady-state output of a Kerr parametric oscillator
- 2021
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Ingår i: Physical Review Research. - 2643-1564. ; 3:2
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Tidskriftsartikel (refereegranskat)abstract
- The output field from a continuously driven linear parametric oscillator may exhibit considerably more squeezing than the intracavity field. Inspired by this fact, we explore the nonclassical features of the steady-state output field of a driven nonlinear Kerr parametric oscillator using a temporal wave packet mode description. Utilizing a new numerical method, we have access to the density matrix of arbitrary wave packet modes. Remarkably, we find that even though the steady-state cavity field is always characterized by a positive Wigner function, the output may exhibit Wigner negativity, depending on the properties of the selected mode.
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| 24. |
- Vikmoen, Olav, et al.
(författare)
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Effects of heavy-load strength training during (neo-)adjuvant chemotherapy on muscle strength, muscle fiber size, myonuclei, and satellite cells in women with breast cancer
- 2024
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Ingår i: The FASEB Journal. - : John Wiley & Sons. - 0892-6638 .- 1530-6860. ; 38:13
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Tidskriftsartikel (refereegranskat)abstract
- To investigate the effects of heavy-load strength training during (neo-)adjuvant chemotherapy in women with breast cancer on muscle strength, body composition, muscle fiber size, satellite cells, and myonuclei. Women with stage I-III breast cancer were randomly assigned to a strength training group (ST, n = 23) performing supervised heavy-load strength training twice a week during chemotherapy, or a usual care control group (CON, n = 17). Muscle strength and body composition were measured and biopsies from m. vastus lateralis collected before the first cycle of chemotherapy (T0) and after chemotherapy and training (T1). Muscle strength increased significantly more in ST than in CON in chest-press (ST: +10 +/- 8%, p < .001, CON: -3 +/- 5%, p = .023) and leg-press (ST: +11 +/- 8%, p < .001, CON: +3 +/- 6%, p = .137). Both groups reduced fat-free mass (ST: -4.9 +/- 4.0%, p < .001, CON: -5.2 +/- 4.9%, p = .004), and increased fat mass (ST: +15.3 +/- 16.5%, p < .001, CON: +16.3 +/- 19.8%, p = .015) with no significant differences between groups. No significant changes from T0 to T1 and no significant differences between groups were observed in muscle fiber size. For myonuclei per fiber a non-statistically significant increase in CON and a non-statistically significant decrease in ST in type I fibers tended (p = .053) to be different between groups. Satellite cells tended to decrease in ST (type I: -14 +/- 36%, p = .097, type II: -9 +/- 55%, p = .084), with no changes in CON and no differences between groups. Strength training during chemotherapy improved muscle strength but did not significantly affect body composition, muscle fiber size, numbers of satellite cells, and myonuclei compared to usual care.
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| 25. |
- Vikmoen, Olav, et al.
(författare)
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Effects of High and Low-To-Moderate Intensity Exercise During (Neo-) Adjuvant Chemotherapy on Muscle Cells, Cardiorespiratory Fitness, and Muscle Function in Women With Breast Cancer : Protocol for a Randomized Controlled Trial
- 2022
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Ingår i: JMIR Research Protocols. - : JMIR Publications Inc.. - 1929-0748. ; 11:11
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Tidskriftsartikel (refereegranskat)abstract
- Background: (Neo-)adjuvant chemotherapy for breast cancer is effective but has deleterious side effects on muscle tissue, resulting in reduced skeletal muscle mass, muscle function, and cardiorespiratory fitness. Various exercise regimens during cancer treatment have been shown to counteract some of these side effects. However, no study has compared the effect of high-intensity training versus low-to-moderate intensity training on muscle tissue cellular outcomes and physical function in patients with breast cancer during chemotherapy.Objective: The aim of this substudy within the Physical Training in Cancer (Phys-Can) consortium is to evaluate and compare the effects of high and low-to-moderate intensity exercise on muscle cellular outcomes, muscle function, and cardiorespiratory fitness in women with breast cancer undergoing (neo-)adjuvant chemotherapy. We further aim to investigate if the effects of chemotherapy including taxanes on muscles will be different from those of taxane-free chemotherapy.Methods: Eighty women recently diagnosed with breast cancer scheduled to start (neo-)adjuvant chemotherapy will be randomized to a combination of strength and endurance training, either at high intensity or at low-to-moderate intensity. Testing of muscle function and cardiorespiratory fitness and collection of muscle biopsies from the vastus lateralis muscle will be performed before the first cycle of chemotherapy (or after 1 week, when not possible) (T0), halfway through chemotherapy (T1), and after completion of chemotherapy (T2). It is estimated that approximately 50% of the participants will be willing to undergo muscle biopsies. To separate the effect of the treatment itself, a usual care group with no supervised training will also be included, and in this group, testing and collection of muscle biopsies will be performed at T0 and T2 only.Results: This study is funded by Active Against Cancer (Aktiv mot kreft) (May 2013) and the Norwegian Cancer Society (December 2018). Inclusion started in December 2016 and the last participant is expected to be recruited in December 2022. As of June 2022, we enrolled 38 (19 with biopsies) participants to the high-intensity training group, 36 (19 with biopsies) participants to the low-to-moderate intensity training group, and 17 (16 with biopsies) participants to the usual care group. Data analyses will start in fall 2022. The first results are expected to be published in spring 2024.Conclusions: This study will generate new knowledge about the effects of different training intensities for women with breast cancer during chemotherapy treatment. It will give further insight into how chemotherapy affects the muscle tissue and how physical training at different intensities may counteract the treatment side effects in muscles. The results of this study will inform
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| 26. |
- Witte, Ingrid, 1978-
(författare)
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A gender perspective on Supported Employment : Does gender influence access, process, and employment outcomes?
- 2024
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Introduction: Several systematic reviews have found the vocational rehabilitation (VR) intervention of Supported Employment (SE) to be more efficient for persons with disabilities to obtain employment than other interventions within VR. Nevertheless, there is a lack of research on how the intervention works for men and women.Aim: To explore the influence of gender on access, processes, and employment outcomes in VR, designed according to the SE method, for men and women with psychiatric, neuropsychiatric, or intellectual disabilities.Methods: Study I was a scoping review to examine what has been reported regarding the influence of different intersecting statuses on the employment rate after participating in an SE intervention. Study II was a focus group study with employment specialists exploring their social representations of gender in relation to disability, VR, and working life .Study III was a qualitative interview study exploring participants’ experiences of SE interventions. Study IV was a mixed method multiple case study using qualitative comparative analysis to explore enabling and barrier conditions in SE interventions.Results: In the triangulation of the four studies, two superordinate themes evolved. In the material, gendered paths through the welfare system resulted in women having less access to SE interventions, and when participating in an SE intervention, women with disabilities with high responsibilities for home and family struggled to find enough resources to focus on vocational rehabilitation.Conclusion: For SE to become more equal and better suited for all persons with disabilities interested in employment, regardless of gender, the accessibility to SE and the SE method needs to be developed to better suit the diversified needs of SE participants.
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| 27. |
- Witte, Ingrid, 1978-, et al.
(författare)
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Does gender matter in Supported Employment? : A qualitative study of participants’ experiences
- 2024
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Ingår i: Journal of Vocational Rehabilitation. - : IOS Press. - 1052-2263 .- 1878-6316.
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: In Sweden, gender differences have been found in standard vocational rehabilitation as well as in evidenced-based methods such as Supported Employment (SE). However, these quantitative findings have not been followed up by qualitative research to clarify the issue.OBJECTIVE: To explore participants’ experiences of participating in an SE intervention and the influence of gender on their experiences.METHOD: Semistructured interviews with 10 women and 7 men participating in SE in Sweden were conducted. Qualitative content analysis followed by a gender analysis were performed using the material.RESULTS: The participating men and women had different background characteristics. Overall, the participants shared the same experiences of SE. They valued a trustful relationship with the employment specialist and the diversified and individualized support from the employment specialist. Unlike the men, the women had experienced difficulties receiving SE from authorities, and when receiving SE, they expressed the value of a slow start, being challenged, and whole-life support.CONCLUSION: The findings might moderate the rapid job principle in SE and indicate the need to acknowledge that the path to employment might look different, depending on the participants’ gendered experiences and living conditions, for SE to be more successful for both men and women.
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| 28. |
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| 29. |
- Witte, Ingrid, 1978-, et al.
(författare)
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Intersectional perspectives on the employment rate in Supported Employment for people with psychiatric, neuropsychiatric, or intellectual disabilities : A scoping review
- 2023
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Ingår i: Work. - : IOS Press. - 1051-9815 .- 1875-9270. ; 74:2, s. 435-454
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Forskningsöversikt (refereegranskat)abstract
- BACKGROUND: Supported Employment (SE) has shown better results in the employment rate for persons with disabilities than other methods within vocational rehabilitation, but how SE affects the employment rate for subgroups in the interventions needs further attention.OBJECTIVE: To examine previous research regarding the influence of intersecting statuses on the employment rate in SE for people with psychiatric, neuropsychiatric, or intellectual disabilities according to type of diagnosis, sex, race/ethnicity, age, level of education and previous work history.METHODS: A systematic literature search was conducted in nine databases including peer-reviewed articles from 2000 to April 2021. Articles presenting the employment rate in SE interventions according to the intersecting statuses listed in the objective were included.RESULTS: The searches identified 3777 unique records, of which 53 articles were included in data extraction. In most of the included articles, intersecting statuses did not affect the employment rate for people in the SE interventions with psychiatric disabilities. Few studies have examined neuropsychiatric and intellectual disabilities. A majority of the studies subjected to full-text analysis were excluded due to a lack of reporting of the effects of intersecting statuses on the employment rate. The studies that reported on the effects of intersecting statuses on the employment rate often had small samples and lacked statistical power.CONCLUSIONS: Intersecting statuses do not appear to affect the employment rate for people receiving SE interventions, but systematic reviews with pooled samples need to be undertaken because of the low reporting rate and underpowered sample sizes in existing studies.
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| 30. |
- Witte, Ingrid, 1978-, et al.
(författare)
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Social representations of gender and their influence in Supported Employment : employment specialists' experiences in Sweden
- 2024
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Ingår i: Disability and Rehabilitation. - : Taylor & Francis. - 0963-8288 .- 1464-5165. ; 46:15, s. 3381-3395
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: Gender differences have been found in the outcomes of vocational rehabilitation (VR) and in Supported Employment (SE), therefore, the purpose of this study was to explore employment specialists' (ES) social representations of gender in relation to work and VR and how these social representations influence the ES's work in the VR process according to SE.METHODS: The qualitative method of focus group discussions was employed. Ten focus groups were held with 39 ESs from four categories of SE organizations in Sweden. Topic analysis was applied to the transcribed material from the focus groups.RESULTS: Five themes with different social representations about gender and disability in relation to VR and working life formed in the analysis: (1) differences in personal and health factors among VR-participants, (2) gender norms in society influencing VR, (3) energy-intensive environmental issues influencing VR, (4) gender-specific interactions in VR, and (5) gendered paths in the welfare system.CONCLUSION: Social representations of higher strains on women with disabilities compared to men with disabilities both in private and working life, which reflect the lived experiences of the ESs, is a possible explanation for gender differences in VR and working life for persons with disabilities.IMPLICATIONS FOR REHABILITATION: Gender differences in the outcomes of vocational rehabilitation (VR) interventions have been noticed worldwide. In this study, pervasive social representations about gender and disability in relation to VR were found, but also unconsciousness about gender among VR professionals. Therefore, awareness of gender is necessary in VR.Individualized and person-centered approaches to VR like Supported Employment, although considered best practice, might hide structures like gender, which could lead to reproducing discriminating processes and therefore not achieving gender equality in VR. Therefore, knowledge of discrimination is important in VR.Gender-sensitivity in vocational rehabilitation models with a person-centered and individualized approach is needed and there might also be a need to systematically tailor vocational rehabilitation models to reach gender equality in the outcomes of the interventions. Therefore, gender equality indicators are needed for VR models, to evaluate model effectiveness from a gender perspective.
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| 31. |
- Yang, Jiaying, 1995, et al.
(författare)
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Deterministic generation of shaped single microwave photons using a parametrically driven coupler
- 2023
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Ingår i: Physical Review Applied. - 2331-7019. ; 20:5
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Tidskriftsartikel (refereegranskat)abstract
- A distributed quantum computing system requires a quantum communication channel between spatially separated processing units. In superconducting circuits, such a channel can be realized by using propagating microwave photons to encode and transfer quantum information between an emitter and a receiver node. Here we experimentally demonstrate a superconducting circuit that deterministically transfers the state of a data qubit into a propagating microwave mode, with a process fidelity of 94.5%. We use a time-varying parametric drive to shape the temporal profile of the propagating mode to be time symmetric and with constant phase, so that reabsorption by the receiving processor can be implemented as a time-reversed version of the emission. We demonstrate a self-calibrating routine to correct for time-dependent shifts of the emitted frequencies due to the modulation of the parametric drive. Our work provides a reliable method to implement high-fidelity quantum state transfer and remote entanglement operations in a distributed quantum computing network.
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