| 1. |
- Schnitzbauer, Andreas A, et al.
(författare)
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A prospective randomised, open-labeled, trial comparing sirolimus-containing versus mTOR-inhibitor-free immunosuppression in patients undergoing liver transplantation for hepatocellular carcinoma.
- 2010
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Ingår i: BMC cancer. - : Springer Science and Business Media LLC. - 1471-2407. ; 10
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Tidskriftsartikel (refereegranskat)abstract
- The potential anti-cancer effects of mammalian target of rapamycin (mTOR) inhibitors are being intensively studied. To date, however, few randomised clinical trials (RCT) have been performed to demonstrate anti-neoplastic effects in the pure oncology setting, and at present, no oncology endpoint-directed RCT has been reported in the high-malignancy risk population of immunosuppressed transplant recipients. Interestingly, since mTOR inhibitors have both immunosuppressive and anti-cancer effects, they have the potential to simultaneously protect against immunologic graft loss and tumour development. Therefore, we designed a prospective RCT to determine if the mTOR inhibitor sirolimus can improve hepatocellular carcinoma (HCC)-free patient survival in liver transplant (LT) recipients with a pre-transplant diagnosis of HCC.
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| 2. |
- Schnitzbauer, Andreas A., et al.
(författare)
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mTOR Inhibition Is Most Beneficial After Liver Transplantation for Hepatocellular Carcinoma in Patients With Active Tumors
- 2020
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Ingår i: Annals of Surgery. - : LIPPINCOTT WILLIAMS & WILKINS. - 0003-4932 .- 1528-1140. ; 272:5, s. 855-862
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Tidskriftsartikel (refereegranskat)abstract
- Objective: The aim of this study was to evaluate the survival benefit of sirolimus in patients undergoing liver transplantation (LT) for hepatocellular carcinoma (HCC) (exploratory analysis of the SiLVER-trial). Summary and Background Data: Patients receiving LT) for HCC are at a high risk for tumor recurrence. Calcineurin inhibitors have shown evidence to promote cancer growth, whereas mammalian target of rapamycin (mTOR) inhibitors like sirolimus have anticancer effects. In the SiLVER-trial (Clinicaltrials.gov:NCT00355862), the effect of sirolimus on the recurrence of HCC after LTwas investigated in a prospective randomized trial. Although the primary endpoint of improved disease-free survival (DFS) with sirolimus was not met, outcomes were improved for patients in the sirolimus-treatment arm in the first 3 to 5 years. To learn more about the key variables, a multivariate analysis was performed on the SiLVER-trial data. Patients and Methods: Data from 508 patients of the intention-to-treat analysis were included in exploratory univariate and multivariate models for overall survival (OS), DFS and a competing risk analysis for HCC recurrence. Results: Sirolimus use for >= 3 months after LT for HCC independently reduced the hazard for death in the multivariate analysis [hazard ratio (HR): 0.7 (95% confidence interval, CI: 0.52-0.96, P = 0.02). Most strikingly, patients with an alpha-fetoprotein (AFP) >= 10 ng/mL and having used sirolimus for >= 3 months, benefited most with regard to OS, DFS, and HCC-recurrence (HR: 0.49- 0.59, P = 0.0079- 0.0245). Conclusions: mTOR-inhibitor treatment with sirolimus for >= 3 months improves outcomes in LT for HCC, especially in patients with AFP-evidence of higher tumor activity, advocating particularly for mTOR inhibitor use in this subgroup of patients. Clinical Trial Registration: EudraCT: 2005-005362-36 Clinicaltrials.gov: NCT00355862.
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| 3. |
- Karnouskos, Stamatis, et al.
(författare)
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Assessing the Integration of Software Agents and Industrial Automation Systems with ISO/IEC 25010
- 2018
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Ingår i: 2018 IEEE 16TH INTERNATIONAL CONFERENCE ON INDUSTRIAL INFORMATICS (INDIN). - : IEEE. - 9781538648292 - 9781538648308 ; , s. 61-66
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Konferensbidrag (refereegranskat)abstract
- Agent-technologies have been used for higher-level decision making in addition to carrying out lower-level automation and control functions in industrial systems. Recent research has identified a number of architectural patterns for the use of agents in industrial automation systems but these practices vary in several ways, including how closely agents are coupled with physical systems and their control functions. Such practices may play a pivotal role in the Cyber-Physical System integration and interaction. Hence, there is a clear need for a common set of criteria for assessing available practices and identifying a best-fit practice for a given industrial use case. Unfortunately, no such common criteria exist currently. This work proposes an assessment criteria approach as well as a methodology to enable the use case based selection of a best practice for integrating agents and industrial systems. The software product quality model proposed by the ISO/IEC 25010 family of standards is used as starting point and is put in the industrial automation context. Subsequently, the proposed methodology is applied, and a survey of experts in the domain is carried out, in order to reveal some insights on the key characteristics of the subject matter.
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| 4. |
- Leitao, Paulo, et al.
(författare)
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Common practices for integrating industrial agents and low level automation functions
- 2017
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Ingår i: IECON 2017 - 43RD ANNUAL CONFERENCE OF THE IEEE INDUSTRIAL ELECTRONICS SOCIETY. - : IEEE. - 9781538611289 - 9781538611272 ; , s. 6665-6670
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Konferensbidrag (refereegranskat)abstract
- Industrial agent technologies have been integrated in key elements coupling industrial systems and software logic, which is an important issue in the design of cyber-physical systems. Although several efforts have been tried out over the last decades to integrate software agents with physical hardware devices, and some commonalities can be observed among the existing practices, there is no uniform way overall. This work presents an empirical survey of existing practices in three application area, namely factory automation, power & energy systems and building automation. It identifies pertaining common issues and discusses how they integrate low level automation functions by utilizing industrial agents. The surveyed practices reveal high diversity, customized traditional integration focusing mostly on I/O functions, without security, and an overall approach that is mostly coupled rather than embedded.
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| 5. |
- Leitao, Paulo, et al.
(författare)
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Recommendation of Best Practices for Industrial Agent Systems based on the IEEE 2660.1 Standard
- 2021
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Ingår i: 2021 22ND IEEE INTERNATIONAL CONFERENCE ON INDUSTRIAL TECHNOLOGY (ICIT). - : IEEE. - 9781728157306 ; , s. 1157-1162
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Konferensbidrag (refereegranskat)abstract
- Cyber-Physical Systems (CPS) is a key concept in Industry 4.0, acting as a backbone to develop smart processes, machines and products. Multi-Agent Systems (MAS) is a suitable paradigm for the realization of such industrial CPS systems, supporting the distribution of intelligence and decision-making capabilities among a network of autonomous and cooperative agents. Standardization is a key factor for the acceptance of industrial CPS and agent-based systems, assuming a critical role in establishing specifications for the hardware integration, which is an important requirement for industrial agents. This paper focuses on the recently established IEEE 2660.1-2020 standard that defines a recommended practice to solve the interface problem when applying industrial agents, namely integrating intelligent software agents with low-level automation devices in the CPS context. The paper illustrates the applicability of the standard in three different application scenarios related to power and energy systems, factory automation and building automation, and discusses future directions in terms of standardization in the field of industrial agents, that are required for its wider adoption in the realization of industrial CPS solutions.
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| 6. |
- Ramos, Eunice, et al.
(författare)
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Capacity development and knowledge transfer on the climate, land, water and energy nexus
- 2022. - 1
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Ingår i: Handbook on the Water-Energy-Food Nexus. - : Edward Elgar Publishing. ; , s. 149-177
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- A significant obstacle to the incorporation of Nexus considerations in planning and policy design is the understanding and acknowledgement of cross-sectoral interdependencies. This chapter explores the importance of disseminating knowledge of the Nexus among key actors from policy, business and civil society, and in formal education contexts. Examples from capacity development activities and Nexus dialogues linked to the implementation of the Climate, Land, Energy and Water systems (CLEWs) framework are presented. Insights from the latter, as well as other initiatives with similar scope of action, are distilled to forward the importance of learning in such an approach. Additionally, the chapter highlights the main aspects to take into account when promoting these types of activities in new Nexus contexts.
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| 7. |
- Ribeiro, Luis, et al.
(författare)
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A community analysis of the IEEE IES industrial agents technical committee
- 2017
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Ingår i: Industrial Electronics Society , IECON 2017 - 43rd Annual Conference of the IEEE. - : IEEE. - 9781538611289 - 9781538611272 ; , s. 6139-6144
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Konferensbidrag (refereegranskat)abstract
- At the dawn of the 4th industrial revolution, the use of software agents, service-oriented architectures and related technologies as primary constructs of Cyber-Physical Industrial systems is of high relevance. Current developments in this area have been consistently supported by an active community of researchers and practitioners in the past decades. Most of the main actors in the area are members of the IEEE IES Technical Community on Industrial Agents (TCIA). This work analyzes the evolution of this research and development network. It does so by identifying and investigating specialized sub-communities within the larger umbrella of Industrial Agents, their research interests and directions. In total of 7430 documents from 8045 authors were collected from the Google Scholar profiles of the TCIA members. The analysis reveals different research trends, transitions over the years and the emergence of application and domain foci, that are critically discussed.
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| 8. |
- Strasser, Thomas I., et al.
(författare)
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A Review of Architectures and Concepts for Intelligence in Future Electric Energy Systems
- 2015
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Ingår i: IEEE Transactions on Industrial Electronics. - 0278-0046 .- 1557-9948. ; 62:4, s. 2424-2438
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Tidskriftsartikel (refereegranskat)abstract
- Renewable energy sources are one key enabler to decrease greenhouse gas emissions and to cope with the anthropogenic climate change. Their intermittent behavior and limited storage capabilities present a new challenge to power system operators to maintain power quality and reliability. Additional technical complexity arises from the large number of small distributed generation units and their allocation within the power system. Market liberalization and changing regulatory framework lead to additional organizational complexity. As a result, the design and operation of the future electric energy system have to be redefined. Sophisticated information and communication architectures, automation concepts, and control approaches are necessary in order to manage the higher complexity of so-called smart grids. This paper provides an overview of the state of the art and recent developments enabling higher intelligence in future smart grids. The integration of renewable sources and storage systems into the power grids is analyzed. Energy management and demand response methods and important automation paradigms and domain standards are also reviewed
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| 9. |
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| 10. |
- Strasser, Thomas I., et al.
(författare)
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Towards an IEC 61499 compliance profile for smart grids review and analysis of possibilities
- 2012
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Ingår i: IECON 2012 - 38th Annual Conference on IEEE Industrial Electronics Society. - : IEEE Communications Society. - 9781467324199 - 9781467324205 ; , s. 3750-3757
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Konferensbidrag (refereegranskat)abstract
- The electric energy system is changing more and more into a Smart Grid. A key technology in order to transform the actual grid is the information and communication technology. This means that advanced management, automation, control and communication concepts and systems have to be developed in order to cope with changing and challenging future requirements in the intelligent grid; especially the large-scale integration of distributed energy systems and electric vehicles. As a result of this trend, the future grid will consist of a huge number of intelligent electronic devices in order to manage the distributed and complex nature of Smart Girds. In order to guarantee a high level of interoperability, which is a major requirement for Smart Grids and its related components and devices, the International Electrotechnical Commission has introduced the IEC 61850 standard for power utility automation. Since it covers only interoperability and communication issues, a proper design, modeling and implementation approach is required. The main aim of this paper therefore is to discuss the usage of IEC 61850 together with the IEC 61499 reference model for distributed automation and the development of a related IEC 61499 Compliance Profile for Smart Grids
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| 11. |
- Sünder, Christoph, et al.
(författare)
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Usability and interoperability of IEC 61499 based distributed automation systems
- 2007
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Ingår i: 2006 4th IEEE International Conference on Industrial Informatics. - Piscataway, NJ : IEEE Communications Society. - 0780397010 - 0780397002 ; , s. 31-37
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Konferensbidrag (refereegranskat)abstract
- Since IEC 61499 has reached the state of an International Standard and a substantial body of research results exists the question of the authors as main intention for this paper was: Do the models of IEC 61499 solve all problems when thinking of usability and interoperability in heterogeneous system environments? The main problems discussed within the paper concern to the execution model defined for basic function blocks and the scheduling of events within function block networks
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| 12. |
- van der Meer, PF, et al.
(författare)
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Aggregates in platelet concentrates
- 2015
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Ingår i: Vox sanguinis. - : Wiley. - 1423-0410 .- 0042-9007. ; 108:1, s. 96-125
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Tidskriftsartikel (refereegranskat)
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| 13. |
- Vrba, Pavel, et al.
(författare)
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A Review of Agent and Service-Oriented Concepts Applied to Intelligent Energy Systems
- 2014
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Ingår i: IEEE Transactions on Industrial Informatics. - 1551-3203 .- 1941-0050. ; 10:3, s. 1890-1903
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Tidskriftsartikel (refereegranskat)abstract
- The intention of this paper is to provide an overview of using agent and service-oriented technologies in intelligent energy systems. It focuses mainly on ongoing research and development activities related to smart grids. Key challenges as a result of the massive deployment of distributed energy resources are discussed, such as aggregation, supply-demand balancing, electricity markets, as well as fault handling and diagnostics. Concepts and technologies like multiagent systems or service-oriented architectures are able to deal with future requirements supporting a flexible, intelligent, and active power grid management. This work monitors major achievements in the field and provides a brief overview of large-scale smart grid projects using agent and service-oriented principles. In addition, future trends in the digitalization of power grids are discussed covering the deployment of resource constrained devices and appropriate communication protocols. The employment of ontologies ensuring semantic interoperability as well as the improvement of security issues related to smart grids is also discussed.
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