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- Koivula, Tiia, et al.
(författare)
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Sex comparison of white blood cell responses to acute vigorous-intensity aerobic exercise
- 2023
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Ingår i: Acta Physiologica. - Chichester : Wiley-Blackwell. - 1748-1708 .- 1748-1716. ; 239:S728, s. 44-45
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Tidskriftsartikel (refereegranskat)abstract
- Background: It is widely accepted that exercise alters the number and function of circulating leukocytes, and many factors are suggested to influence this phenomenon. The aim here was to compare white blood cell mobilization between sexes after acute vigorous-intensity exercise bout.Methods: The study included healthy and physically active subjects, 10 men (aged 26 (SD 7) years) and 10 women (aged 33 (SD 8) years). Participants performed a 30-min cycling ergometer exercise at 70% VO2max. Blood samples were drawn at rest and 3 min, 1 and 2 h post-exercise. Changes in total leukocyte, neutrophil, lymphocyte, monocyte, eosinophil, and basophil count were analyzed and corrected for plasma volume change.Results: Women had higher lymphocyte counts and lower eosinophil proportion of total leukocytes compared to men at all time points. Acute exercise significantly increased the number of total leukocytes and all leukocyte subpopulations excluding eosinophils in both women and men. The mobilization of all leukocyte subpopulations was similar in both sexes, but mobilization of total leukocytes, as a percentage change from rest, was greater in men. Increase in total leukocyte, neutrophil, and lymphocyte counts correlated positively with lactate concentration at 3-min timepoint and decrease in lymphocyte and basophil count after exercise correlated negatively with mean exercising heart rate in both sexes.Conclusion: Our findings indicate that mobilization of total leukocytes is greater in men. The sex-difference however is small and not observed in any leukocyte subpopulations. Further, exercise intensity driven physiological perturbation has a role in immune cell mobilization.
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| 2. |
- Tuisku, Jouni, et al.
(författare)
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Effects of age, BMI and sex on the glial cell marker TSPO : a multicentre [11C]PBR28 HRRT PET study
- 2019
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Ingår i: European Journal of Nuclear Medicine and Molecular Imaging. - : Springer. - 1619-7070 .- 1619-7089. ; 46:11, s. 2329-2338
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Tidskriftsartikel (refereegranskat)abstract
- Purpose The purpose of this study was to investigate the effects of ageing, sex and body mass index (BMI) on translocator protein (TSPO) availability in healthy subjects using positron emission tomography (PET) and the radioligand [C-11]PBR28. Methods [C-11]PBR28 data from 140 healthy volunteers (72 males and 68 females; N = 78 with HAB and N = 62 MAB genotype; age range 19-80 years; BMI range 17.6-36.9) were acquired with High Resolution Research Tomograph at three centres: Karolinska Institutet (N = 53), Turku PET centre (N = 62) and Yale University PET Center (N = 25). The total volume of distribution (V-T) was estimated in global grey matter, frontal, temporal, occipital and parietal cortices, hippocampus and thalamus using multilinear analysis 1. The effects of age, BMI and sex on TSPO availability were investigated using linear mixed effects model, with TSPO genotype and PET centre specified as random intercepts. Results There were significant positive correlations between age and V-T in the frontal and temporal cortex. BMI showed a significant negative correlation with V-T in all regions. Additionally, significant differences between males and females were observed in all regions, with females showing higher V-T. A subgroup analysis revealed a positive correlation between V-T and age in all regions in male subjects, whereas age showed no effect on TSPO levels in female subjects. Conclusion These findings provide evidence that individual biological properties may contribute significantly to the high variation shown in TSPO binding estimates, and suggest that age, BMI and sex can be confounding factors in clinical studies.
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