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Träfflista för sökning "WFRF:(Sun Tianshu) "

Search: WFRF:(Sun Tianshu)

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1.
  • Gao, Xindi, et al. (author)
  • Cryptococcal Hsf3 controls intramitochondrial ROS homeostasis by regulating the respiratory process
  • 2022
  • In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 13:1
  • Journal article (peer-reviewed)abstract
    • Mitochondrial quality control prevents accumulation of intramitochondrial-derived reactive oxygen species (mtROS), thereby protecting cells against DNA damage, genome instability, and programmed cell death. However, underlying mechanisms are incompletely understood, particularly in fungal species. Here, we show that Cryptococcus neoformans heat shock factor 3 (CnHsf3) exhibits an atypical function in regulating mtROS independent of the unfolded protein response. CnHsf3 acts in nuclei and mitochondria, and nuclear- and mitochondrial-targeting signals are required for its organelle-specific functions. It represses the expression of genes involved in the tricarboxylic acid cycle while promoting expression of genes involved in electron transfer chain. In addition, CnHsf3 responds to multiple intramitochondrial stresses; this response is mediated by oxidation of the cysteine residue on its DNA binding domain, which enhances DNA binding. Our results reveal a function of HSF proteins in regulating mtROS homeostasis that is independent of the unfolded protein response.
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2.
  • Wei, Yizhen, et al. (author)
  • Widely tunable L-band brillouin fiber laser incorporating a bismuth-based erbium-doped fiber
  • 2009
  • In: Optics InfoBase Conference Papers. - Washington, D.C. : OSA. - 9781557528773
  • Conference paper (peer-reviewed)abstract
    • We proposed a widely tunable single-wavelength Brillouin fiber laser (BFL) by employing a bismuth-based erbium-doped fiber (Bi-EDF). The BFL operates in a range from 1555 nm to 1632 nm, which is the widest to the best of our knowledge. It's an attractive narrow linewidth laser source on the L-band.
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