| 1. |
- Ahrné, Karin, et al.
(author)
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Tillstånd och trender för arter och deras livsmiljöer – rödlistade arter i Sverige 2015
- 2015
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Reports (other academic/artistic)abstract
- 2015 års upplaga av den svenska rödlistan är den fjärde i ordningen. Den är baserad på IUCN:s rödlistningskriterier och revideras vart femte år. I rödlistan bedöms risken som enskilda arter av djur, växter och svampar löper att försvinna från Sverige. Bedömningen utförs av ArtDatabankens medarbetare i samverkan med över 100 externa experter, indelade i 14 expertkommittéer för olika organismgrupper. Under arbetet med 2015 års rödlista har tillstånd och trender bedömts för 21 600 arter och 1 318 lägre taxa (apomiktiska arter, underarter och varieteter), sammanlagt ca 22 900 taxa. Av de bedömda arterna klassificerades 2 029 som hotade (kategorierna CR, EN och VU) och 4 273 som rödlistade (inkluderar även kategorierna NT, RE och DD). Förhållandet mellan antalet rödlistade och antalet bedömda arter ar 19,8 %, vilket är ungefär samma värde som 2010 och 2005. I denna rapport jämförs antalet och andelen rödlistade arter mellan olika organismgrupper, biotoper, substrat och påverkansfaktorer. Texten ar indelad i en allmän del och åtta kapitel inriktade på olika landskapstyper. Landskapstyperna utgör en grov indelning av landets miljöer enligt följande kategorier: Skog, Jordbrukslandskap, Urbana miljöer, Fjäll, Våtmarker, Sötvatten, Havsstränder och Havsmiljöer. Skogen och jordbrukslandskapet är de artrikaste landskapstyperna med 1 800 respektive 1 400 arter som har en stark anknytning dit, och ytterligare flera hundra arter som förekommer där mer sporadiskt. De faktorer som påverkar flest rödlistade arter i Sverige är skogsavverkning och igenväxning, som båda utgör ett hot mot vardera ca 30 % av de rödlistade arterna. Avverkning minskar arealen av skog där naturliga strukturer och naturlig dynamik upprätthålls, och den orsakar därmed förlust av livsmiljöer. Igenväxning orsakas av ett antal faktorer, bland annat upphörande hävd (bete och slåtter), gödsling, trädplantering och brist på naturliga störningsregimer som t.ex. regelbundna översvämningar kring vattendrag och sjöar. Andra viktiga påverkansfaktorer är fiske, torrläggning av våtmarker, tillbakagång hos värdarter (främst alm och ask som drabbats av invasiva svampsjukdomar), klimatförändringar och konkurrens från invasiva arter. IUCN:s rödlisteindex beräknas för ett urval av de bedömda organismgrupperna. Rödlisteindex visar att skillnaderna mellan rödlistorna från 2000, 2005, 2010 och 2015 är små. Ett par undantag finns dock. Groddjur och stora däggdjur har fått en något förbättrad situation sedan 2000. Totalt förefaller det ändå som att trycket mot Sveriges artstock har förblivit relativt konstant under de senaste 15 åren.
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| 2. |
- Sundberg, Sebastian, et al.
(author)
-
Våtmarker
- 2015
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In: Tillstånd och trender för arter och deras livsmiljöer - rödlistade arter i Sverige 2015. - 9789187853135 ; :17, s. 41-45
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Book chapter (other academic/artistic)abstract
- Våtmarker, bl.a. myrar och sötvattensstränder, hyser totalt drygt 800 rödlistade arter, och för nästan 470 av dessa är våtmarkerna särskilt viktiga livsmiljöer. De flesta artgrupper har representanter här, men kärlväxter, lavar, tvåvingar och skalbaggar är särskilt artrika. Även mossor, fjärilar, fåglar och landmollusker är väl representerade. Rikkärr och sötvattensstränder är de artrikaste våtmarksmiljöerna. De rödlistade våtmarksarterna hotas främst av igenväxning, dikning, vattenreglering och eutrofiering. Restaurering, fortsatt och utökad hävd samt nyskapande av våtmarker är viktiga åtgärder, liksom återgång till naturlig vattenföring och vattenståndsdynamik i strandnära miljöer.
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| 3. |
- Bjelke, Ulf, et al.
(author)
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Rödlistade arter och naturvård i sand- och grustäkter
- 2012
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Reports (other academic/artistic)abstract
- Naturligt störningspräglade sandmarker hyser en artrik och konkurrenskänslig flora och fauna. Sådana livsmiljöer har minskat drastiskt under 1900-talet. Under samma period ökade antalet sand- och grustäkter. Trots att täkterna ofta innebär stora ingrepp i naturen kan de utgöra viktiga ersättningshabitat för arter knutna till sandiga miljöer. Sedan några decennier så minskar även sand- och grustäkter starkt, beroende på att samhället vill bevara naturliga sand- och grusresurser. Produktionen har medvetet flyttats till bergkrossanläggningar och det ges idag mycket få tillstånd för utökad verksamhet eller nya sandtäkter. Från fler än 5 000 aktiva täkter på 1990-talet har antalet sjunkit till färre än 1 000. Täkter som avslutas har ofta föreskrifter om att planas ut och övertäckas vilket gör att deras naturvärden spolieras. Drygt 300 rödlistade arter har gynnats av sandtäkter när ursprungshabitaten minskat. Steklar och skalbaggar utgör de största grupperna med närmare två tredjedelar av arterna. Södra Sverige hyser störst rikedom av dessa arter men såväl täkter som arternas mer naturliga miljöer är bristfälligt undersökta, särskilt i glest befolkade delar av landet. För att bevara dessa täktlevande arter krävs att naturvården arbetar för att förhindra att avslutade täkter planas ut eller täcks över. Det är av stor betydelse att naturvårdande myndigheter ges tillräckliga styrmedel och ekonomiska resurser att arbeta med täkter. Genom enkla åtgärder kan de skapade livsmiljöerna i täkter bevaras till en låg kostnad jämfört med andra alternativa biotopvårdande åtgärder. Rapporten belyser artsamhällena som kan finnas i täkter samt viktiga strategier och åtgärder för naturvård i dessa miljöer. Rapporten har finansierats av Naturvårdsverket och av SLU:s medel för fortlöpande miljöanalys.
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| 4. |
- Neve, Etienne P A, et al.
(author)
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Amidoxime Reductase System Containing Cytochrome b5 Type B (CYB5B) and MOSC2 Is of Importance for Lipid Synthesis in Adipocyte Mitochondria
- 2012
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In: Journal of Biological Chemistry. - 0021-9258 .- 1083-351X. ; 287:9, s. 6307-6317
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Journal article (peer-reviewed)abstract
- Reduction of hydroxylamines and amidoximes is important for drug activation and detoxification of aromatic and heterocyclic amines. Such a reductase system was previously found to be of high activity in adipose tissue and liver, and furthermore, in vitro studies using recombinant truncated and purified enzymes suggested the participation of cytochrome b(5) reductase (CYB5R), cytochrome b(5) (CYB5), and molybdenum cofactor sulfurase C-terminal containing 1 and 2 (MOSC1 and -2). Here, we show that purified rat liver outer mitochondrial membrane contains high amidoxime reductase activity and that MOSC2 is exclusively localized to these membranes. Moreover, using the same membrane fraction, we could show direct binding of a radiolabeled benzamidoxime substrate to MOSC2. Following differentiation of murine 3T3-L1 cells into mature adipocytes, the MOSC2 levels as well as the amidoxime reductase activity were increased, indicating that the enzyme is highly regulated under lipogenic conditions. siRNA-mediated down-regulation of MOSC2 and the mitochondrial form of cytochrome b(5) type B (CYB5B) significantly inhibited the reductase activity in the differentiated adipocytes, whereas down-regulation of MOSC1, cytochrome b(5) type A (CYB5A), CYB5R1, CYB5R2, or CYB5R3 had no effect. Down-regulation of MOSC2 caused impaired lipid synthesis. These results demonstrate for the first time the direct involvement of MOSC2 and CYB5B in the amidoxime reductase activity in an intact cell system. We postulate the presence of a novel reductive enzyme system of importance for lipid synthesis that is exclusively localized to the outer mitochondrial membrane and is composed of CYB5B, MOSC2, and a third unknown component (a CYB5B reductase).
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| 5. |
- Sundberg, Sebastian, et al.
(author)
-
Havsstränder
- 2015
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In: Tillstånd och trender för arter och deras livsmiljöer - rödlistade arter i Sverige 2015. - 9789187853135 ; :17, s. 51-56
-
Book chapter (other academic/artistic)abstract
- Sveriges mångformiga kust - med sand-, grus- och klippstränder, dyner och strandängar - hyser drygt 270 rödlistade arter för vilka havsstränderna är viktiga livsmiljöer. Här ingår många arter av fåglar, kärlväxter, spindeldjur, skalbaggar, fjärilar och groddjur. Havsstrandängar och sandiga miljöer är särskilt artrika. Havsstrandsarterna hotas främst av igenväxning, exploatering, mänsklig störning av häckningsplatser och livsmiljöer samt nedskräpning. De viktigaste åtgärderna är att återskapa blottade sandstränder och dyner, att säkerställa en välanpassad hävd av strandängar samt att minska föroreningar och marin nedskräpning.
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| 6. |
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| 7. |
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| 8. |
- Andersson, Håkan S., 1967-, et al.
(author)
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The toxicity of ribbon worms: alpha-nemertides or tetrodotoxin, or both?
- 2016
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In: Planta Medica. - : Georg Thieme Verlag KG. - 0032-0943 .- 1439-0221. ; 82:Supplement 1
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Journal article (other academic/artistic)abstract
- The marine ribbon worms (nemerteans) are predators which capture their prey by everting a proboscis carrying a mixture of toxins which brings on rapid paralysis [1]. Moreover, ribbon worms have a thick layer of epidermal mucus of similar constitution. Tetrodotoxin (TTX) has been identified as one of these toxins [2]. The extreme toxicity of TTX (lethal by ingestion of 0.5-2 mg) is due to its ability to block voltage-gated sodium channels. Although several bacterial species (among these Vibrio sp.) have been linked to its synthesis, the biogenic origin and biosynthesis is unclear. One hypothesis is that TTX production occurs in a symbiotic relationship with its host, in this case the ribbon worm [3]. We have made significant effort to identify TTX in a setup for production through the cultivation of Vibrio alginolyticus in nutrient broth infused with mucus from the ribbon worm Lineus longissimus. Toxicity was demonstrated by fraction injections into shore crabs, but no TTX was found, and it could be shown conclusively that toxicity was unrelated to TTX and the Vibrio culture itself, and rather a constituent of the ribbon worm mucus [4]. The following studies led us to the discovery of a new class of peptides, the alpha-nemertides, in the mucus of the ribbon worms, which could be directly linked to the toxic effects. A literature review of the available evidence for TTX in ribbon worms show that the evidence in most cases are indirect, although notable exceptions exist. This points to the necessity to further investigate the presence and roles of TTX and alpha-nemertides in ribbon worms.
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| 9. |
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| 10. |
- Aronsson, Mora, et al.
(author)
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Sveriges arter och naturtyper i EU:s art- och habitatdirektiv : Resultat från rapportering 2019 till EU av bevarandestatus 2013-2018
- 2020
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Reports (other academic/artistic)abstract
- Sverige har en variationsrik natur med storslagen fjällmiljö, myllrande våtmarker, vattendrag och sjöar, kust och hav, skogar och odlingslandskap, alla med ett rikt växt och djurliv. Den här fantastiska biologiska mångfalden tas ofta för given och ibland som en lyx, men oavsett vilket är det en förutsättning för vår överlevnad.2019 rapporterade Sverige statusen till EU för perioden 2013–2018 för de naturtyper och arter i Sverige som är listade i art- och habitatdirektivet. Den berättar att 20 procent av naturtyperna och 40 procent av arterna mår bra. Den biologiska mångfalden är hårt trängd i såväl Sverige som i andra EU-länder.Den här rapporten sammanfattar Sveriges rapportering och innehåller beskrivningar av status för naturtyper och arter, påverkan, hot och trender. Rapporten ger kunskap om tillståndet för den biologiska mångfalden i Sverige med hjälp av de arter och naturtyper som är listade i EU:s art- och habitatdirektiv.Rapporten visar hur naturmiljöerna i Sverige förändas, och sammanfattar den senaste kunskapen om vilka faktorer som driver dessa förändringar. Även exempel på hur vi genom restaurerings- och skötselåtgärder kan hejda förlusten av biologisk mångfald tas upp.
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| 11. |
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| 12. |
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| 13. |
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| 14. |
- Carlson, R. F., et al.
(author)
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A method for measuring light ion reaction cross-sections
- 2005
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In: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 547:2-3, s. 541-554
-
Journal article (peer-reviewed)abstract
- An experimental procedure for measuring reaction cross-sections of light ions in the energy range 20 50 MeV/nucleon, using a modified attenuation technique, is described. The detection method incorporates a forward detector that simultaneously measures the reaction cross-sections for five different sizes of the solid angle in steps from 99.1% to 99.8% of the total solid angle. The final reaction cross-section values are obtained by extrapolation to the full solid angle.
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| 15. |
- De Graeve, Diana, et al.
(author)
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Equity in the delivery of health care in Europe and the US
- 2000
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In: Journal of health economics. - : Elsevier B.V. - 1879-1646 .- 0167-6296. ; 19:5, s. 553-583
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Journal article (peer-reviewed)abstract
- This paper presents a comparison of horizontal equity in health care utilization in 10 European countries and the US. It does not only extend previous work by using more recent data from a larger set of countries, but also uses new methods and presents disaggregated results by various types of care. In all countries, the lower-income groups are more intensive users of the health care system. But after indirect standardization for need differences, there is little or no evidence of significant inequity in the delivery of health care overall, though in half of the countries, significant pro-rich inequity emerges for physician contacts. This seems to be due mainly to a higher use of medical specialist services by higher-income groups and a higher use of GP care among lower-income groups. These findings appear to be fairly general and emerge in countries with very diverse characteristics regarding access and provider incentives.
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| 16. |
- Donev, Evgeniy N., et al.
(author)
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Field testing of transgenic aspen from large greenhouse screening identifies unexpected winners
- 2023
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In: Plant Biotechnology Journal. - : Wiley. - 1467-7644 .- 1467-7652. ; 21:5, s. 1005-1021
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Journal article (peer-reviewed)abstract
- Trees constitute promising renewable feedstocks for biorefinery using biochemical conversion, but their recalcitrance restricts their attractiveness for the industry. To obtain trees with reduced recalcitrance, large-scale genetic engineering experiments were performed in hybrid aspen blindly targeting genes expressed during wood formation and 32 lines representing seven constructs were selected for characterization in the field. Here we report phenotypes of five-year old trees considering 49 traits related to growth and wood properties. The best performing construct considering growth and glucose yield in saccharification with acid pretreatment had suppressed expression of the gene encoding an uncharacterized 2-oxoglutarate-dependent dioxygenase (2OGD). It showed minor changes in wood chemistry but increased nanoporosity and glucose conversion. Suppressed levels of SUCROSE SYNTHASE, (SuSy), CINNAMATE 4-HYDROXYLASE (C4H) and increased levels of GTPase activating protein for ADP-ribosylation factor ZAC led to significant growth reductions and anatomical abnormalities. However, C4H and SuSy constructs greatly improved glucose yields in saccharification without and with pretreatment, respectively. Traits associated with high glucose yields were different for saccharification with and without pretreatment. While carbohydrates, phenolics and tension wood contents positively impacted the yields without pretreatment and growth, lignin content and S/G ratio were negative factors, the yields with pretreatment positively correlated with S lignin and negatively with carbohydrate contents. The genotypes with high glucose yields had increased nanoporosity and mGlcA/Xyl ratio, and some had shorter polymers extractable with subcritical water compared to wild-type. The pilot-scale industrial-like pretreatment of best-performing 2OGD construct confirmed its superior sugar yields, supporting our strategy.
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| 17. |
- Friman, Tomas, 1980-
(author)
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Extracellular Matrix and Connective Tissue Cells of the Tumor Microenvironment
- 2010
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Doctoral thesis (other academic/artistic)abstract
- In addition to malignant cells, solid tumors comprise supporting stromal tissue that consists of extra cellular matrix (ECM), connective tissue cells, inflammatory cells and blood vessels. The stromal compartment and the malignant cells together shape the tumor microenvironment that in turn determines tumor progression and efficacy of anti-tumor treatments. In this thesis, studies that investigate the roles of different kinds of interactions between tumor cells and stromal cells were undertaken. Further, growth factors that have important roles in interactions between tumor cells and stromal cells were investigated in a non-tumor environment. Tumor cells were found to modulate the response to the platelet derived growth factor (PDGF) by microvascular pericytes, a cell type found in the vasculature of solid tumors. The importance of this growth factor in biology of tumors has earlier been shown, but here it was shown that PDGF also modulate the ECM phenotype of solid tumors. The ECM of tumors treated with an inhibitor of PDGF receptor (PDGFR) signaling induced a less fibrotic collagen scaffold, which could explain how PDGFR inhibition in earlier reports lowered tumor interstitial fluid pressure (IFP). Lowering the normally high IFP in tumors increases efficacy of chemotherapy. The integrin αVβ3 is activated downstream of PDGF-B in acute inflammations, and this integrin is important for raising IFP in loose connective tissue in such conditions. However, in tumors we found that lack of the β3 subunit lead to an increased IFP, which were attributed to a more fibrotic ECM phenotype. In addition to PDGF-B, transforming growth factor β (TGFβ) is an important growth factor in the biology of tumors. These two growth factors were separately overexpressed in mouse skin and they both induced an inflammatory response. Expressed in a tumor free context, they evoked a response that was in many ways reminiscent of what can be observed in the tumor microenvironment. This thesis contributes further understanding of how the complex tumor microenvironment affects the phenotype of solid tumors.
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| 18. |
- Gerdtham, Ulf-G, et al.
(author)
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Equity in the delivery of health care in Sweden
- 1998
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In: SCANDINAVIAN JOURNAL OF SOCIAL MEDICINE. - : SCANDINAVIAN UNIVERSITY PRESS. - 0300-8037. ; 26:4, s. 259-264
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Journal article (peer-reviewed)abstract
- There is mutual agreement that health care should be delivered according to need. In this article, although we employ different specifications for need, we conclude that there is inequity in the delivery of health care in Sweden. Higher income groups visi
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| 19. |
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| 20. |
- Gerdtham, Ulf-G, Sundberg, Gun
(author)
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Sjukvårdens rättvisa fördelning
- 1997
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In: Ekonomisk Debatt. - : Nationalekonomiska föreningen. ; 25:7, s. 305-306
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Journal article (other academic/artistic)
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| 21. |
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| 22. |
- Gidlund, Eva-Karin, et al.
(author)
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Humanin skeletal muscle protein levels increase after resistance training in men with impaired glucose metabolism
- 2016
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In: Physiological Reports. - : Wiley. - 2051-817X. ; 4:23
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Journal article (peer-reviewed)abstract
- Humanin (HN) is a mitochondrially encoded and secreted peptide linked to glucose metabolism and tissue protecting mechanisms. Whether skeletal muscle HN gene or protein expression is influenced by exercise remains unknown. In this intervention study we show, for the first time, that HN protein levels increase in human skeletal muscle following 12 weeks of resistance training in persons with prediabetes. Male subjects (n = 55) with impaired glucose regulation (IGR) were recruited and randomly assigned to resistance training, Nordic walking or a control group. The exercise interventions were performed three times per week for 12 weeks with progressively increased intensity during the intervention period. Biopsies from the vastus lateralis muscle and venous blood samples were taken before and after the intervention. Skeletal muscle and serum protein levels of HN were analyzed as well as skeletal muscle gene expression of the mitochondrially encoded gene MT-RNR2, containing the open reading frame for HN. To elucidate mitochondrial training adaptation, mtDNA, and nuclear DNA as well as Citrate synthase were measured. Skeletal muscle HN protein levels increased by 35% after 12 weeks of resistance training. No change in humanin protein levels was seen in serum in any of the intervention groups. There was a significant correlation between humanin levels in serum and the improvements in the 2 h glucose loading test in the resistance training group. The increase in HN protein levels in skeletal muscle after regular resistance training in prediabetic males may suggest a role for HN in the regulation of glucose metabolism. Given the preventative effect of exercise on diabetes type 2, the role of HN as a mitochondrially derived peptide and an exercise-responsive mitokine warrants further investigation.
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| 23. |
- Grandin, Martina, et al.
(author)
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Ti-Ni-C nanocomposite coatings evaluated in a sliding electrical contact application
- 2015
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In: Surface & Coatings Technology. - : Elsevier BV. - 0257-8972 .- 1879-3347. ; 276, s. 210-218
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Journal article (peer-reviewed)abstract
- Nanocomposite Ti-Ni-C coatings, with nanosized carbide grains in an amorphous carbon (a-C) matrix have been suggested to have low friction and low contact resistance making them suitable for sliding electrical contacts. In this study we investigate further the previously observed influence of the amount of amorphous carbon, in a test set-up simulating instrumentation and control applications. The tribological and electrical performance is evaluated at high speed and continuous sliding against silver-graphite, where the mechanical load and current are fairly low. It is shown that under these circumstances there is no significant influence from the amount of a-C on neither the contact resistance nor the amount of wear of the silver-graphite. The reason for this is suggested to be that similar tribofilms are formed on the surface of the coatings, regardless of the amount of a-C phase. Degradation of the nanocomposite coatings is observed under electrical load, even though they are both much harder than the silver-graphite counter surface.
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| 24. |
- Gustavsson, Jenny, et al.
(author)
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Bioavailability of cobalt and nickel during anaerobic digestion of sulfur-rich stillage for biogas formation
- 2013
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In: Applied Energy. - : Elsevier. - 0306-2619 .- 1872-9118. ; 112, s. 473-477
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Journal article (peer-reviewed)abstract
- Addition of Co and Ni often improves the production of biogas during digestion of organic matter, i.e. increasing CH4-production, process stability and substrate utilization which often opens for higher organic loading rates (OLRs). The effect of Co and Ni addition was evaluated by measuring methane production, volatile solids reduction, pH and concentration of volatile fatty acids (VFAs). A series of six lab-scale semi-continuously fed biogas tank reactors were used for this purpose. The chemical forms and potential bioavailability of Co and Ni were examined by sequential extraction, acid volatile sulfide extraction (AVS) and simultaneously extracted metals. Furthermore, the sulfur speciation in solid phase was examined by sulfur X-ray absorption near edge structure spectroscopy. The effect of Co and Ni deficiency on the microbial community composition was analyzed using quantitative polymerase chain reaction and 454-pyrosequencing. The results showed that amendment with Co and Ni was necessary to maintain biogas process stability and resulted in increased CH4-production and substrate utilization efficiency. 10-20% of the total Co concentration was in dissolved form and should be regarded as easily accessible by the microorganisms. In contrast, Ni was entirely associated with organic matter/sulfides (mainly AVS) and regarded as very difficult to take up. Still Ni had stimulatory effects suggesting mechanisms such as dissolution of NiS to be involved in the regulation of Ni availability for the microorganisms. The microbial community structure varied in relation to the occurrence of Ni and Co. The acetate-utilizing Methanosarcinales dominated during stable process performance, i.e. when both Co and Ni were supplied, while hydrogenotrophic Methanomicrobiales increased together with VFA concentrations under Co or Ni deficiency. The increase was more pronounced at Co limitation. This study demonstrates that there are good possibilities to improve the performance of biogas processes digesting sulfur-rich substrates by supplementation of Co and Ni.
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| 25. |
- Haenel, Quiterie, et al.
(author)
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NGS-based biodiversity and community structure analysis of meiofaunal eukaryotes in shell sand from Hållö island, Smögen, and soft mud from Gullmarn Fjord, Sweden
- 2017
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In: Biodiversity Data Journal. - : Oleksandr Holovachov. - 1314-2828 .- 1314-2836. ; 5
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Journal article (peer-reviewed)abstract
- © Haenel Q et al. Aim: The aim of this study was to assess the biodiversity and community structure of Swedish meiofaunal eukaryotes using metabarcoding. To validate the reliability of the metabarcoding approach, we compare the taxonomic resolution obtained using the mitochondrial cytochrome oxidase 1 (COI) 'mini-barcode' and nuclear 18S small ribosomal subunit (18S) V1-V2 region, with traditional morphology-based identification of Xenacoelomorpha and Nematoda. Location: 30 samples were analysed from two ecologically distinct locations along the west coast of Sweden. 18 replicate samples of coarse shell sand were collected along the northeastern side of Hållö island near Smögen, while 12 replicate samples of soft mud were collected in the Gullmarn Fjord near Lysekil.
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| 26. |
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| 27. |
- Hedenström, Mattias, et al.
(author)
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Visualization and interpretation of OPLS models based on 2D NMR Data
- 2008
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In: Chemometrics and Intelligent Laboratory Systems. - : Elsevier. - 0169-7439 .- 1873-3239. ; 92:2, s. 110-117
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Journal article (peer-reviewed)abstract
- Multivariate analysis on spectroscopic 1H NMR data is well established in metabolomics and other fields where the composition of complex samples is studied. However, biomarker identification can be hampered by overlapping resonances. 2D NMR data provides a more detailed “fingerprint” of the chemical structure and composition of the sample with greatly improved spectral resolution compared to 1H NMR data. In this report, we demonstrate a procedure for the construction of multivariate models based on frequency domain 2D NMR data where the loadings can be visualized as highly informative 2D loading spectra. This method is based on the analysis of raw spectral data without any need for peak picking or integration prior to analysis. Spectral features such as line widths and peak positions are thus retained. Hence, the loadings can be visualized and interpreted on a molecular level as pseudo 2D spectra in order to identify potential biomarkers. To demonstrate this strategy we have analyzed HSQC spectra acquired from populus phloem plant extracts originating from a set of designed experiments with OPLS regression.
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| 28. |
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| 29. |
- Isaeva, Leyla, et al.
(author)
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Amorphous W-S-N thin films: the atomic structure behind ultra-low friction
- 2015
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In: Acta Materialia. - : Elsevier BV. - 1359-6454 .- 1873-2453. ; 82, s. 84-93
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Journal article (peer-reviewed)abstract
- Amorphous W–S–N in the form of thin films has been identified experimentally as an ultra-low friction material, enabling easy sliding by the formation of a WS2 tribofilm. However, the atomic-level structure and bonding arrangements in amorphous W–S–N, which give such optimum conditions for WS2 formation and ultra-low friction, are not known. In this study, amorphous thin films with up to 37 at.% N are deposited, and experimental as well as state-of-the-art ab initio techniques are employed to reveal the complex structure of W–S–N at the atomic level. Excellent agreement between experimental and calculated coordination numbers and bond distances is demonstrated. Furthermore, the simulated structures are found to contain N bonded in molecular form, i.e. N2, which is experimentally confirmed by near edge X-ray absorption fine structure and X-ray photoelectron spectroscopy analysis. Such N2 units are located in cages in the material, where they are coordinated mainly by S atoms. Thus this ultra-low friction material is shown to be a complex amorphous network of W, S and N atoms, with easy access to W and S for continuous formation of WS2 in the contact region, and with the possibility of swift removal of excess nitrogen present as N2 molecules.
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| 30. |
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| 31. |
- Johansson, Ulf S, et al.
(author)
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Build-up of the Himalayan avifauna through immigration : A biogeographical analysis of the Phylloscopus and Seicercus warblers
- 2007
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In: Evolution. - : Wiley. - 0014-3820 .- 1558-5646. ; 61:2, s. 324-333
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Journal article (peer-reviewed)abstract
- The Himalayan mountain range is one of the most species-rich areas in the world, harboring about 8% of the world's bird species. In this study, we compare the relative importance of immigration versus in situ speciation to the build-up of the Himalayan avifauna, by evaluating the biogeographic history of the Phylloscopus/Seicercus warblers, a speciose clade that is well represented in Himalayan forests. We use a comprehensive, multigene phylogeny in conjunction with dispersal-vicariance analysis to discern patterns of speciation and dispersal within this clade. The results indicate that virtually no speciation has occurred within the Himalayas. Instead, several speciation events are attributed to dispersal into the Himalayas followed by vicariance between the Himalayas and China/Southeast Asia. Most, perhaps all, of these events appear to be pre-Pleistocene. The apparent lack of speciation within the Himalayas stands in contrast to the mountain-driven Pleistocene speciation suggested for the Andes and the East African mountains.
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| 32. |
- Kádas, Krisztina, et al.
(author)
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Formation of 2D transition metal dichalcogenides on TiC1-xAx surfaces (A=S, Se, Te) : A theoretical study
- 2014
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In: Journal of Materials Research. - : Springer Science and Business Media LLC. - 0884-2914 .- 2044-5326. ; 29:2, s. 207-214
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Journal article (peer-reviewed)abstract
- Using first principle density functional calculations, we study the formation of 2D transition metaldichalcogenides (TMDs) on TiC1-xAx, (A = S, Se, and Te) surfaces. We examine the structural misfits between chalcogen-containing TiC and different TMDs and demonstrate that the conditions for formation of TMDs are fulfilled in TiC1-xAx. We also demonstrate the influence of chalcogens on the cohesive properties and electronic structure of the carbides. We find that they react with W and form W-dichalcogenides. In the experimentally reported Ti–C–S nanocomposite coatings, the carbide grains are embedded in an amorphous carbon matrix. We discuss here the role ofthis matrix in the reaction. We propose that TiC1-xTex and TiC1-xSex are the favorable sources fordichalcogenide formation and suggest an alternative way to produce 2D materials in general. Furthermore, we argue that using Ti–C–Te or Ti–C–Se in nanocomposite coatings may be more advantageous for tribological applications than that of Ti–C–S.
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| 33. |
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| 34. |
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| 35. |
- Lönngren, Ann-Sofie, 1974-
(author)
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Att röra en värld : en queerteoretisk analys av erotiska trianglar i sex verk av August Strindberg
- 2007
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Doctoral thesis (other academic/artistic)abstract
- The subject of this dissertation is a queertheoretical analysis of erotic triangles with two men and one woman, in six texts by August Strindberg (1849–1912). The material consists of the novel A Madman’s Defence (1887–88) and the plays Creditors (1888), Playing with Fire (1892), Crime and Crime (1899), Dance of Death I (1901) and To Damascus I–III (1898–1901). Employing a queer understanding of the history of sexuality and a theoretical frame provided mainly by Judith Butler, I interpret the manifestation of “sex” within the above-mentioned texts as constructed by performative means, in particular those intimately linked to expressions of same-sex and different-sex erotic desires. With Eve Kosofsky Sedgwick’s term “homosocial desire” I direct the attention of the analysis primarily to the dynamic relationship between the male rivals within the erotic triangle. What consequences do the erotic desires have for the gender-categories in the triangular formation, and do they change over a longer time-span in Strindberg’s writings? The result of the study is that the sexual desires of the literary characters within the erotic triangle is of crucial importance for their status as legitimately gendered subjects, and ultimately as acceptable human beings, within the heteronormative context. Moreover, the triangular formation does not alter particularly over time, and the same elements keep occurring with only minor differences between the texts. This process I interpret, within the context of Jacques Derrida’s term “reiteration”, as a means to construct gendered characters that is at one and the same time normative and understandable, as well as dynamic and with a potential for change. In this construction the simultaneous threat and potential of same-sex erotic desires is of crucial importance as it enables new ways to move, create and touch a world.
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| 36. |
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| 37. |
- Nyberg, Harald, et al.
(author)
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Extreme friction reductions during inital running-in of W-S-C-Ti low-friction coatings
- 2013
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In: Wear. - : Elsevier. - 0043-1648 .- 1873-2577. ; 302:1-2 SI, s. 987-997
-
Journal article (peer-reviewed)abstract
- The disulphides of tungsten and molybdenum are known for their low friction properties when used as solid lubricants. Due to their low hardness, their load bearing capacity when used as thin films is poor. When carbon is added to a WS2 coating, both of these shortcomings are improved, and a structure consisting of nanocrystals of WS2, and possibly tungsten carbide, in a matrix of amorphous carbon is formed. In this study, an attempt is made for further increasing the hardness of such coatings, by addition of Ti, a strong carbide former. A number of W–S–C(–Ti) coatings were deposited using magnetron co-sputtering, and characterised with regard to chemical composition, structure and tribological properties. It was seen that addition of Ti significantly increased the hardness of the coatings, while maintaining their excellent low friction properties in dry atmosphere. However, the coatings with Ti showed extremely high initial friction, a feature not seen for the coatings without Ti. The mechanisms behind this running-in behaviour were investigated by studying surfaces at early stages of wear. It was observed that tribofilms formed during sliding for the coatings containing Ti consisted mainly of TiO2, with platelets of WS2 appearing in the contact only after prolonged sliding. For the pure W–S–C coatings, WS2 was observed in the sliding interface almost instantly at the onset of sliding.
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| 38. |
- Nyberg, Harald, et al.
(author)
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Tribochemical formation of sulphide tribofilms from a Ti-C-S coating sliding against different counter surfaces
- 2014
-
In: Tribology letters. - : Springer Science+Business Media B.V.. - 1023-8883 .- 1573-2711. ; 56:3, s. 563-572
-
Journal article (peer-reviewed)abstract
- Tribochemically active Ti-C-S coatings are nanocomposite coatings containing a S-doped titanium carbide, from which S can be released in a tribological contact. This work studies tribochemical reactions between a Ti-C-S coating and various counter surface materials, and their effect on the tribological performance. Tribological tests were performed in a ball-on-disc set-up, using balls of five different materials as sliding partners for the coating: 100Cr6 steel, pure W, WC, 316-L steel and Al2O3. For W balls, a WS2 tribofilm was formed, leading to low friction (down to A mu = 0.06). Furthermore, increasing normal load on the W balls was found to lead to a strong decrease in A mu and earlier formation of the low-friction WS2 tribofilm. Similar WS2 and MoS2 tribofilms were, however, not formed from WC- and Mo-containing 316-L balls. The performance when using WC and Al2O3 balls was significantly worse than for the two steel balls. It is suggested that this is due to sulphide formation from Fe, analogous to formation of anti-seizure tribofilms from S-containing extreme pressure additives and steel surfaces. The tribochemical activity of Ti-C-S coatings, with the possibility of S release, is thus beneficial not only for pure W counter surfaces, but also for Fe-based sliding partners.
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| 39. |
- Röös, Elin, et al.
(author)
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Risks and opportunities of increasing yields in organic farming. A review
- 2018
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In: Agronomy for Sustainable Development. - : Springer-Verlag France. - 1774-0746 .- 1773-0155. ; 38:2
-
Journal article (peer-reviewed)abstract
- Current organic agriculture performs well in several sustainability domains, like animal welfare, farm profitability and low pesticide use, but yields are commonly lower than in conventional farming. There is now a re-vitalized interest in increasing yields in organic agriculture to provide more organic food for a growing, more affluent population and reduce negative impacts per unit produced. However, past yield increases have been accompanied by several negative side-effects. Here, we review risks and opportunities related to a broad range of sustainability domains associated with increasing yields in organic agriculture in the Northern European context. We identify increased N input, weed, disease and pest control, improved livestock feeding, breeding for higher yields and reduced losses as the main measures for yield increases. We review the implications of their implementation for biodiversity, greenhouse gas emissions, nutrient losses, soil fertility, animal health and welfare, human nutrition and health and farm profitability. Our findings from this first-of-its-kind integrated analysis reveal which strategies for increasing yields are unlikely to produce negative side-effects and therefore should be a high priority, and which strategies need to be implemented with great attention to trade-offs. For example, increased N inputs in cropping carry many risks and few opportunities, whereas there are many risk-free opportunities for improved pest control through the management of ecosystem services. For most yield increasing strategies, both risks and opportunities arise, and the actual effect depends on management including active mitigation of side-effects. Our review shows that, to be a driving force for increased food system sustainability, organic agriculture may need to reconsider certain fundamental principles. Novel plant nutrient sources, including increased nutrient recycling in society, and in some cases mineral nitrogen fertilisers from renewable sources, and truly alternative animal production systems may need to be developed and accepted.
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| 40. |
- Sanchez, Vera Victoria, et al.
(author)
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The Physcomitrium patens egg cell expresses several distinct epigenetic components and utilizes homologues of BONOBO genes for cell specification
- 2022
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In: New Phytologist. - : John Wiley & Sons. - 0028-646X .- 1469-8137. ; 233:6, s. 2614-2628
-
Journal article (peer-reviewed)abstract
- Although land plant germ cells have received much attention, knowledge about their specification is still limited. We thus identified transcripts enriched in egg cells of the bryophyte model species Physcomitrium patens, compared the results with angiosperm egg cells, and selected important candidate genes for functional analysis. We used laser-assisted microdissection to perform a cell-type-specific transcriptome analysis on egg cells for comparison with available expression profiles of vegetative tissues and male reproductive organs. We made reporter lines and knockout mutants of the two BONOBO (PbBNB) genes and studied their role in reproduction. We observed an overlap in gene activity between bryophyte and angiosperm egg cells, but also clear differences. Strikingly, several processes that are male-germline specific in Arabidopsis are active in the P. patens egg cell. Among those were the moss PbBNB genes, which control proliferation and identity of both female and male germlines. Pathways shared between male and female germlines were most likely present in the common ancestors of land plants, besides sex-specifying factors. A set of genes may also be involved in the switches between the diploid and haploid moss generations. Nonangiosperm gene networks also contribute to the specification of the P. patens egg cell.
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| 41. |
- Siedlecka, Anna, et al.
(author)
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Pectin methyl esterase inhibits intrusive and symplastic cell growth in developing wood cells of Populus
- 2008
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In: Plant Physiology. - : Oxford University Press (OUP). - 0032-0889 .- 1532-2548. ; 146, s. 554-65
-
Journal article (peer-reviewed)abstract
- Wood cells, unlike most other cells in plants, grow by a unique combination of intrusive and symplastic growth. Fibers grow in diameter by diffuse symplastic growth, but they elongate solely by intrusive apical growth penetrating the pectin-rich middle lamella that cements neighboring cells together. In contrast, vessel elements grow in diameter by a combination of intrusive and symplastic growth. We demonstrate that an abundant pectin methyl esterase (PME, EC 3.1.1.11) from wood-forming tissues of hybrid aspen (Populus tremula L. x tremuloides Michx.) acts as a negative regulator of both symplastic and intrusive growth of developing wood cells. When PttPME1expression was up- and down-regulated in transgenic aspen trees, the PME activity in wood-forming tissues was correspondingly altered. PME removes methyl ester groups from homogalacturonan, and the transgenic trees had modified homogalacturonan methylesterification patterns, as demonstrated by two-dimensional NMR and immunostaining using PAM1 and LM7 antibodies. The in situ distributions of PAM1 and LM7 epitopes revealed changes in pectin methylesterification in the transgenic trees that were specifically localized in expanding wood cells. The results show that en-block de-esterification of homogalacturonan by PttPME1 inhibits both symplastic growth and intrusive growth. PttPME1 is therefore involved in mechanisms determining fiber width and length in the wood of aspen trees.
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| 42. |
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| 43. |
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| 44. |
- Sonesson, Ulf, et al.
(author)
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Paths to a sustainable food sector: integrated design and LCA of future food supply chains : the case of pork production in Sweden
- 2016
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In: The International Journal of Life Cycle Assessment. - : Springer Ferlag. - 0948-3349 .- 1614-7502. ; 21:5, s. 664-676
-
Journal article (peer-reviewed)abstract
- Purpose: To describe a more sustainable food sector, a supply chain approach is needed. Changing a supply chain inevitably means that various attributes of the product and its system will change. This project assumed this challenge and delivered detailed descriptions, life cycle assessment (LCA) evaluations, and consequence assessments of the supply chains of six commodities, i.e., milk, cheese, beef, pork, chicken, and bread, from a Swedish region. This paper presents results for the pork supply chain. Methods: In the project setup, experts on production along supply chains designed three scenarios for environmentally improved systems. These scenarios, i.e., the ecosystem, plant nutrients, and climate scenarios, were intended to address different clusters of environmental goals. The next step was to challenge these scenarios by considering their possible consequences for products and systems from the food safety, sensory quality, animal welfare, consumer appreciation, and (for primary production only) cost perspectives. This led to changes in production system design to prevent negative consequences. The final supply chains were quantified using LCA and were again assessed from the three perspectives. Results and discussion: The scenario design approach worked well, thoroughly and credibly describing the production systems. Assessment of consequences bolstered the credibility and quality of the systems and results. The LCA of pig production and smoked ham identified large potentials for improvement by implementing available knowledge: global warming potential (GWP) could be reduced 21–54 % and marine eutrophication by 14–45 %. The main reason for these improvements was improved productivity (approaching the best producers’ current performance), though dedicated measures were also important, resulting in increased nitrogen efficiency, more varied crop rotations for crop production and better production management, and improved animal health and manure management for animal production. Reduced post-farm wastage contributed as did reduced emissions from fertilizer production. Conclusions: The working approach applied was successful in integrating LCA research with food system production expertise to deliver results relevant to supply chain decision-makers. The consequence assessments brought considerable value to the project, giving its results greater credibility. By introducing constraints in the form of “no negative consequences and no increased costs,” the work was “guided” so that the scenario design avoided being hampered by too many opportunities.
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| 45. |
- Strand, Malin, et al.
(author)
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The Bacterial (Vibrio alginolyticus) Production of Tetrodotoxin in the Ribbon Worm Lineus longissimus-Just a False Positive?
- 2016
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In: Marine Drugs. - Basel : MDPI AG. - 1660-3397. ; 14:4
-
Journal article (peer-reviewed)abstract
- We test previous claims that the bacteria Vibrio alginolyticus produces tetrodotoxin (TTX) when living in symbiosis with the nemertean Lineus longissimus by a setup with bacteria cultivation for TTX production. Toxicity experiments on the shore crab, Carcinus maenas, demonstrated the presence of a paralytic toxin, but evidence from LC-MS and electrophysiological measurements of voltage-gated sodium channel-dependent nerve conductance in maleWistar rat tissue showed conclusively that this effect did not originate from TTX. However, a compound of similar molecular weight was found, albeit apparently non-toxic, and with different LC retention time and MS/MS fragmentation pattern than those of TTX. We conclude that C. maenas paralysis and death likely emanate from a compound <5 kDa, and via a different mechanism of action than that of TTX. The similarity in mass between TTX and the Vibrio-produced low-molecular-weight, non-toxic compound invokes that thorough analysis is required when assessing TTX production. Based on our findings, we suggest that re-examination of some published claims of TTX production may be warranted.
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| 46. |
- Ståhle, Alexander, et al.
(author)
-
Designguide för Smarta gator
- 2022
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Book (other academic/artistic)abstract
- Designguiden för smarta gator konkretiserar hur de fyra megatrenderna urbanisering, digitalisering, samhällsförändringar och miljöförändringar leder till nya krav och utformningsprinciper för framtidens gator. Guiden är tänkt att fungera som en inspiration och ett underlag för att förnya svensk gatupolicy på nationell, regional och kommunal nivå.Guiden innehåller utöver en inledning följande kapitel: en historisk tillbakablick (gatans utveckling), gatans användning, gatans delar, gatans design, designprocessen, guidens genomförande.
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| 47. |
- Sundberg, Erik, et al.
(author)
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Systemic TNF blockade does not modulate synovial expression of the pro-inflammatory mediator HMGB1 in rheumatoid arthritis patients : a prospective clinical study
- 2008
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In: Arthritis Research & Therapy. - : Springer Science and Business Media LLC. - 1478-6362 .- 1478-6354. ; 10:2, s. R33-
-
Journal article (peer-reviewed)abstract
- Introduction High-mobility group box chromosomal protein 1 (HMGB1) has recently been identified as an endogenous mediator of arthritis. TNF and IL-1 beta, pivotal cytokines in arthritis pathogenesis, both have the ability to induce the release of HMGB1 from myeloid and dendritic cells. It was, therefore, decided to investigate whether treatment based on TNF blockade in rheumatoid arthritis (RA) affects the expression of synovial HMGB1. Methods Repeated arthroscopy-guided sampling of synovial tissue was performed in nine patients with RA before and nine weeks after initiation of anti-TNF mAb (infliximab) therapy. Synovial biopsy specimens were analysed for HMGB1 protein by immunohistochemical staining and for HMGB1 mRNA expression by real-time reverse transcriptase PCR (RT-PCR). Statistical evaluations were based on Wilcoxon's signed rank tests or Spearman rank sum tests. Results Aberrant, extranuclear HMGB1 and constitutive nuclear HMGB1 expression, with histological signs of inflammation, were evident in all biopsies obtained before infliximab therapy. Signs of inflammation were still evident in the second biopsies obtained nine weeks after initiation of infliximab therapy. The cytoplasmic and extracellular expression of HMGB1 decreased in five patients, remained unchanged in one patient and increased in three patients, making the overall change in HMGB1 protein expression not significant. No correlation between the clinical response, as measured by disease activity score calculated for 28 joints (DAS28) or the American College of Rheumatology response criteria (ACR 20, 50, and 70), and the direction of change of HMGB1 expression in individual patients could be discerned. In addition, infliximab therapy did not alter HMGB1 mRNA synthesis. Conclusion Pro-inflammatory HMGB1 expression during rheumatoid synovitis was not consistently influenced by TNF-blocking therapy with infliximab. This suggests that TNF is not the main inducer of extranuclear HMGB1 during synovitis and that HMGB1 may represent a TNF-independent molecule that could be considered as a possible target for future therapeutic intervention in RA.
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| 48. |
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| 49. |
- Sundberg, Jill, 1986-, et al.
(author)
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Influence of composition, structure and testing atmosphere on the tribological performance of W-S-N coatings
- 2014
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In: Surface & Coatings Technology. - : Elsevier. - 0257-8972 .- 1879-3347. ; 258, s. 86-94
-
Journal article (peer-reviewed)abstract
- W-S-N coatings deposited by reactive magnetron sputtering offer the possibility of ultra-low friction in unlubricated sliding. In this work, W-S-N coatings of different composition and structure have been deposited, characterised and evaluated with respect to the tribological performance and tribofilm formation. The composition was varied by changing the flow of N-2 into the deposition chamber, leading to N contents ranging from 0 to 47 at.%. W-S-N coatings deposited without substrate heating are amorphous, while substrate heating results in coatings containing nanocystalline tungsten sulphide (WSx) for low N contents, and nanocrystalline tungsten nitride (WyN) at a high N content. The coatings were tribologically tested against steel balls in four different atmospheres dry N-2, dry air, humid N-2 and humid air to study the effects of atmospheric O-2 and H2O both separately and simultaneously. In dry N-2, all coatings exhibited an excellent performance with very low friction (mu approximate to 0.02) and wear. Notably, this included the N-richest and hardest coating, containing nanocrystalline WyN and only 13 at.% of S. The friction and wear increased on changing the atmosphere, in the order of dry air-humid N-2-humid air. In these three non-inert atmospheres, the friction and wear also increased with increasing N content of the coating. It is thus concluded that the presence of O-2, the presence of H2O, and a high N content (i.e., low Wand S contents) are three factors increasing the risk of high friction and wear, especially when occurring together. Raman spectroscopy mapping of the contact surfaces on the coatings and the balls showed that low friction and wear is connected to the presence of WS2 tribofilms in the contact, and that the three previously mentioned factors affect the formation and function of this tribofilm.
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| 50. |
- Sundberg, Jill, et al.
(author)
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Influence of Ti addition on the structure and properties of low-friction W–S–C coatings
- 2013
-
In: Surface & Coatings Technology. - : Elsevier. - 0257-8972 .- 1879-3347. ; 232, s. 340-348
-
Journal article (peer-reviewed)abstract
- Transition metal dichalcogenides, such as WS2 and MoS2, are known for their layered structure and lubricating properties. When deposited as thin coatings, however, their use as solid lubricants is limited by their low hardness and load-bearing capacity. The addition of another element, such as carbon, can improve the mechanical properties, although the hardness of for example W-S-C coatings is still rather low. In this work, Ti has been added to W-S-C coatings in order to further increase the hardness by carbide formation. W-S-C and W-S-C-Ti coatings were deposited by non-reactive magnetron sputtering, and characterized with regard to composition, structure and mechanical and tribological properties. It was found that the addition of Ti leads to the formation of a new carbide phase, and a significant increase in hardness for coatings with moderate carbon contents. The friction properties of W-S-C-Ti coatings were found to be comparable to that of W-S-C coatings, with friction coefficients down to mu approximate to 0.02 and similar wear rates against steel in a dry atmosphere. Formation of WS2 in the wear track of W-S-C-Ti was confirmed by transmission electron microscopy. It has thus been shown that the addition of Ti to W-S-C coatings can increase the hardness, while still maintaining WS2 lubrication.
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