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- Stegmayr, B G, et al.
(författare)
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Wegener granulomatosis in children and young adults. A case study of ten patients.
- 2000
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Ingår i: Pediatric nephrology (Berlin, West). - : Springer Science and Business Media LLC. - 0931-041X .- 1432-198X. ; 14:3, s. 208-13
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Tidskriftsartikel (refereegranskat)abstract
- This retrospective study reports seven children and three young adults (aged 11-30 years) who suffered from Wegener granulomatosis. Nine represent consecutive patients admitted to the Division of Nephrology over a period of 23 years. All patients had respiratory tract symptoms and renal involvement on admission. In several patients infiltrates on chest X-ray developed within 2 weeks of onset of symptoms. All patients survived. The median observation period was 9 years (range 13 months to 23 years). One patient progressed to end-stage renal disease. Nine patients initially received cyclophosphamide and steroids. After a median period of 9 months (range 6-31 months) the cyclophosphamide was replaced by azathioprine. Relapses occurred after a median of 28 months (range 4-120 months) in 80% of patients, in six of the eight patients causing a definite decrease in kidney function. We believe that early diagnosis and initiation of therapy reduce the extent of organ damage. Since relapses are frequent, these patients should be evaluated frequently.
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| 15. |
- Andersson, B, et al.
(författare)
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Ökad fysisk aktivitet viktigt för att bromsa sjukfrånvaron
- 2015
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Ingår i: Dagens nyheter, DN.
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Försäkringskassans rapport (DN Debatt 27/11 2015) visar att sjukfrånvaron fortsätter att öka och lovar att kraftsamla i sjukförsäkringshandläggningen. Men, precis som Försäkringskassan skriver, kommer det inte att räcka för att nå regeringens mål. Regeringens åtgärdsprograms program i sju punkter för att minska sjukfrånvaron saknar en viktig komponent. Det måste kompletteras med fysisk aktivitet som ett åttonde område för att trenden ska kunna brytas, skriver 13 debattörer.
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| 16. |
- Emmoth, Birger, et al.
(författare)
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In-situ measurements of carbon and deuterium deposition using the fast reciprocating probe in TEXTOR
- 2009
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Ingår i: Journal of Nuclear Materials. - : Elsevier BV. - 0022-3115 .- 1873-4820. ; 390-91, s. 179-182
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Tidskriftsartikel (refereegranskat)abstract
- Silicon samples were exposed in the scrape-off layer of the TEXTOR plasma using a fast reciprocating probe, with the aim of studying carbon deposition and deuterium retention during Dynamic Ergodic Divertor (DED) operation. Separate samples were exposed for 300 ms at the flat-top phase of neutral beam heated discharges. The exposure conditions were varied on a shot-to-shot basis by external magnetic perturbations generated by the DED in the m/n = 3/1, DC regime, base configuration. Nuclear Reaction Analysis (NRA) was used to characterise collector sample surfaces after their exposure. Enhanced concentrations of both carbon and deuterium (C 3-10 x 10(16) at./cm(2), D 8-60 x 10(15) at./cm(2)) were found. The D/C ratio was less than unity which indicates that most of the carbon and deuterium were co-deposited. Carbon e-folding lengths of about 2 cm were found on both toroidal sides of the probe independent of DED perturbations.
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| 17. |
- Förlin, Lars, 1950, et al.
(författare)
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Effektscreening –Biologisk effektövervakning i förorenade områdenlängs Sveriges kust2017–2018
- 2019
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Undersökningarna visar att samtliga metoder inklusive undersökningar av hälsotillståndet hos fisk, fortplantning och biomarkörer hos vitmärla, lysosomal membranstabilitet hos mussla och imposex hos snäckor med få undantag visade på tydliga effekter i de åtta undersökta och förorenade områdena längs Sveriges kuster. En jämförelse mellan de olika metoderna visar, med undantag för området i Uddevalla/Byfjorden, en tydlig påverkan i resterande undersökta områdena. I Byfjorden noterades mindre stressade musslor och endast låga stadier av imposex hos snäckor medan fiskhälsan kunde konstateras vara påverkad. Utöver Byfjorden gjordes undersökningar med mer än en av metoderna även i Sundsvallsfjärden, Norrsundet, Bråviken, Ronnebyåns mynning och Landskrona. I dessa områden visar jämförelsen mellan metoderna att samtliga indikerar en tydlig påverkan. Att samtliga metoder ger utslag beror sannolikt på att alla valda undersökningsområden har en mycket komplex och ganska påtaglig föroreningsbelastning vilket innebär att det kan förväntas att de flesta organismer som lever i dessa områden kan uppvisa effekter som kan härledas till påverkan av miljöstörande ämnen. I Sverige är den nationella effektbaserade miljöövervakningen i marin miljö väsentligen inriktad på att undersöka effekter av miljögifter i referensområden. Sådana områden karakteriseras av att de ska ligga på stort avstånd från större befolkningscentra och industrier, eller till exempel inte ligga nära stora flodmynningar. Resultaten från denna studie kompletterar den ordinarie miljöövervakningen i referensområden och visar med stor tydlighet att de undersökta områdena är källor för miljöstörande ämnen till vattenmiljön. Undersökningarna visar också att det är önskvärt att kontinuerlig biologisk effektövervakning kommer igång i något eller några påverkade områden inom ramen för den nationella miljöövervakningen för att parallellt följa förändringar i miljön nära eller en bit från påtagliga, mer eller mindre kontinuerliga föroreningskällor i vårt samhälle. Detta skulle också komplettera Sveriges internationella rapportering av miljödata genom att förutom att rapportera effektdata från referensområden även kunna rapportera data från påverkade/förorenade områden.
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- Gunnarsson, I, et al.
(författare)
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HLA-DRB1*0301 and DQA1*0501 in RA
- 2001
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Ingår i: Annals of the rheumatic diseases. - : BMJ. - 0003-4967. ; 60:7, s. 727-727
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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- Sergienko, G., et al.
(författare)
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Experience with bulk tungsten test-limiters under high heat loads : melting and melt layer propagation
- 2007
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Ingår i: Physica Scripta. - 0031-8949 .- 1402-4896. ; T128, s. 81-86
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Tidskriftsartikel (refereegranskat)abstract
- The paper provides an overview of processes and underlying physics governing tungsten melt erosion in the fusion plasma environment. Experiments with three different bulk tungsten test-limiters were performed in TEXTOR: (i) thermally insulated solid plate fixed on a graphite roof-like limiter heated up by the plasma to the melting point, (ii) macro-brush of the ITER-relevant castellated structure and (iii) lamellae structure developed for the JET divertor. The main objectives were to determine the metal surface damage, the formation of the melt layer and its motion in the magnetic field. PHEMOBRID-3D and MEMOS-1.5D numerical codes were used to simulate the experiment with the roof-like test-limiter. Both experiments and simulation showed that the melting of tungsten can lead to a large material redistribution due to thermo-electron emission currents without ejection of molten material to the plasma.
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| 27. |
- Bengtsson, B, et al.
(författare)
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Barns tillväxt, en hälsoindikator
- 1996
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Ingår i: Läkartidningen. ; 93, s. 1241-
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 28. |
- Bolk, Jenny, et al.
(författare)
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Association of Perinatal and Childhood Ischemic Stroke With Attention-Deficit/Hyperactivity Disorder
- 2022
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Ingår i: JAMA Network Open. - : American Medical Association. - 2574-3805. ; 5:4
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Tidskriftsartikel (refereegranskat)abstract
- IMPORTANCE Early detection of attention-deficit/hyperactivity disorder (ADHD) plays a crucial role in reducing negative effects on everyday life, including academic failure and poor social functioning. Children who survive ischemic strokes risk major disabilities, but their risk of ADHD has not been studied in nationwide cohorts. OBJECTIVE To assess the risk of ADHD in children after pediatric ischemic stroke. DESIGN, SETTING, AND PARTICIPANTS Participants in this Swedish nationwide cohort study included 1320 children diagnosed with ischemic stroke recorded in linked Swedish national registers from January 1, 1969, to December 31, 2016, without prior ADHD diagnosis. Ten matched controls were identified for each index case, and first-degree relatives were identified for index individuals and controls. Analyses were stratified by perinatal and childhood strokes and presence of comorbid adverse motor outcomes and/or epilepsy. End of follow-up was the date of ADHD diagnosis, death, or December 31, 2016, whichever occurred first. Data analyses were performed August 1 to 28, 2021. EXPOSURES Pediatric ischemic stroke. MAIN OUTCOMES AND MEASURES Attention-deficit/hyperactivity disorder identified using codes from the International Classification of Diseases, Ninth Revision, and international Statistical Classification of Diseases and Related Health Problems, Tenth Revision, and/or prescribed ADHD medication recorded in the Medical Birth Register, National Patient Register, or Prescribed Drug Register after stroke. Cox proportional hazards regression was used to assess adjusted hazard ratios (aHRs) for ADHD after pediatric stroke, adjusting for parental age and ADHD in first-degree relatives. RESULTS Of 1320 children with stroke included in the analysis (701 boys [53.1%]), 75 (45 boys [60.0%]) were diagnosed with ADHD after stroke compared with 376 (252 boys [67.0%]) among the controls (aHR, 2.00 [95% CI, 1.54-2.60]). The risk was increased after both perinatal (aHR, 2.75 [95% CI, 1.65-4.60]) and childhood (aHR, 1.82 [95% CI, 1.34-2.48]) strokes and were similar if children born preterm or small for gestational age were excluded. Compared with controls, risks of ADHD were higher among children with perinatal stroke and adverse motor outcomes and/or epilepsy (aHR, 6.17 [95% CI, 2.80-13.62]) than among those without these comorbidities (aHR, 1.65 [95% CI, 0.80-3.42]). However, findings were similar in childhood stroke for children with adverse motor outcomes and/or epilepsy (aHR, 1.80 [95% CI, 1.12-2.89]) and among those without these comorbidities (aHR, 1.92 [95% CI, 1.28-2.90]). CONCLUSIONS AND RELEVANCE This cohort study of 1320 children with pediatric ischemic stroke suggests that there is an increased risk of ADHD. particularly in children with adverse motor outcomes and/or epilepsy, compared with controls. The risk increases after childhood strokes regardless of comorbidities.
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| 32. |
- Forsander, Gun, 1951, et al.
(författare)
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Influence of the initial management regimen and family social situation on glycemic control and medical care in children with type I diabetes mellitus.
- 2000
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Ingår i: Acta paediatrica (Oslo, Norway : 1992). - 0803-5253. ; 89:12, s. 1462-8
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- It is well known that social family factors are of importance in diabetes care, but it is not clear whether the initial management regimen can buffer these factors. In a prospective, randomized intervention study, 36 children with diabetes mellitus (type I) were followed, the aim being to study if a family psychosocial intervention at diagnosis could improve glycemic control and minimize hospital admissions. The control group was treated initially in a hospital ward, while the study group received problem-based learning and family-therapeutic and social support in an out-hospital training apartment. A number of family social variables were evaluated at the time of diagnosis and 6, 12 and 24 mo later. Family function was assessed using the self-estimated Family Climate Test at these same time-points. HbAlc values and information concerning in- and out-hospital visits to the pediatric clinic were collected for the 5-y period following diagnosis. We found no association between the offered management regimen and glycemic control or rate of readmission. In the study group only, both parents reported a significant improvement of the family climate. An increased risk for poor glycemic control was recorded in children living in one-parent families (p = 0.03) or in families where the father had a low level of education (p = 0.04). Younger age (p = 0.05), a single-parent family (p = 0.05) and poor glycemic control (p = 0.02) were associated with more days of rehospitalization. The rate of divorce in the whole group was at least as high as in the normal population but, surprisingly, maternal dysfunction was associated with lower HbAlc value. The conclusion is that even with an initial management regimen designed to offer a family-individual care regimen based on accurate estimation of the psychological and pedagogical needs, the social family background is a most important factor for the glycemic control and need for readmission.
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| 33. |
- Forsander, Gun, 1951, et al.
(författare)
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Metabolic control in children with insulin-dependent diabetes mellitus 5 y after diagnosis. Early detection of patients at risk for poor metabolic control.
- 1998
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Ingår i: Acta paediatrica (Oslo, Norway : 1992). - 0803-5253. ; 87:8, s. 857-64
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Tidskriftsartikel (refereegranskat)abstract
- Children (n = 38) aged 3-15 y were randomly chosen, at the time of diabetes diagnosis, for conventional management at a hospital ward, or for treatment partly in a training apartment where the family was offered problem-based education and special therapeutic support. HbA1c, blood glucose stability, urinary C-peptide excretions and incidence of hypoglycaemic attacks and diabetes ketoacidosis (DKA) were monitored and some standardized, self-estimated psychological tests were performed during the first 2 y after diagnosis. During the 3 y thereafter, HbA1c, presence of DKA, microalbuminuria, retinopathy and hypertension were monitored. None of the patients demonstrated signs of diabetes microangiopathy or DKA. The overall mean HbA1c level was 7.2% 5 y after diagnosis and 30% of the children had HbA1c values <6.3%. There were no differences in the HbA1c values for the patients treated by the different management regimens. Blood glucose variability (SD) was also similar, with 75% of the values in the range of 3-10 mmol/l. Patients with poor glycaemic control (mean HbA1c >8.3%) year 5 after diagnosis had already the second year after diagnosis significantly higher HbA1c values and blood glucose variability. The fathers of these patients demonstrated a higher degree of maladjustment. On the basis of increasing HbA1c values, high blood glucose variability and psychosocial risk factors such as their fathers' emotional responses, patients at risk for poor metabolic control in the future can be identified within 2 y after diagnosis. Efforts and resources can thus be focused at an early stage on this group.
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| 35. |
- Gasior, P., et al.
(författare)
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Laser-induced removal of co-deposits from graphitic plasma-facing components : Characterization of irradiated surfaces and dust particles
- 2009
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Ingår i: Journal of Nuclear Materials. - : Elsevier BV. - 0022-3115 .- 1873-4820. ; 390-91, s. 585-588
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Tidskriftsartikel (refereegranskat)abstract
- Laser-induced fuel desorption and ablation of co-deposited layers on limiter plates from the TEXTOR tokamak have been studied. Gas phase composition was monitored in situ, whereas the ex situ studies have been focused on the examination of irradiated surfaces and broad analysis of dust generated by ablation of co-deposits. The size of the dust grains is in the range of few nanometers to hundreds of micrometers. These are fuel-rich dust particles, as determined by nuclear reaction analysis. The presence of deuterium in dust indicates that not all fuel species are transferred to the gas phase during irradiation. This also suggests that photonic removal of fuel and the ablation of co-deposit from plasma-facing components may lead to the redistribution of fuel-containing dust to surrounding areas.
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