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| 2. |
- Wade, G. A., et al.
(författare)
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The MiMeS survey of magnetism in massive stars : introduction and overview
- 2016
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 456:1, s. 2-22
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The MiMeS (Magnetism in Massive Stars) project is a large-scale, high-resolution, sensitive spectropolarimetric investigation of the magnetic properties of O- and early B-type stars. Initiated in 2008 and completed in 2013, the project was supported by three Large Program allocations, as well as various programmes initiated by independent principal investigators, and archival resources. Ultimately, over 4800 circularly polarized spectra of 560 O and B stars were collected with the instruments ESPaDOnS (Echelle SpectroPolarimetric Device for the Observation of Stars) at the Canada-France-Hawaii Telescope, Narval at the Telescope Bernard Lyot and HARPSpol at the European Southern Observatory La Silla 3.6 m telescope, making MiMeS by far the largest systematic investigation of massive star magnetism ever undertaken. In this paper, the first in a series reporting the general results of the survey, we introduce the scientific motivation and goals, describe the sample of targets, review the instrumentation and observational techniques used, explain the exposure time calculation designed to provide sensitivity to surface dipole fields above approximately 100 G, discuss the polarimetric performance, stability and uncertainty of the instrumentation, and summarize the previous and forthcoming publications.
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| 11. |
- Eriksson, Ola, et al.
(författare)
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Municipal Solid Waste Management from a Systems Perspective
- 2005
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Ingår i: Journal of Cleaner Production. - : Elsevier BV. - 0959-6526 .- 1879-1786. ; 13:3, s. 241-252
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Tidskriftsartikel (refereegranskat)abstract
- Different waste treatment options for municipal solid waste have been studied in a systems analysis. Different combinations of incineration, materials recycling of separated plastic and cardboard containers, and biological treatment (anaerobic digestion and composting) of biodegradable waste, were studied and compared to landfilling. The evaluation covered use of energy resources, environmental impact and financial and environmental costs. In the study, a calculation model ( ) based on methodology from life cycle assessment (LCA) was used. Case studies were performed in three Swedish municipalities: Uppsala, Stockholm, and Älvdalen. The study shows that reduced landfilling in favour of increased recycling of energy and materials lead to lower environmental impact, lower consumption of energy resources, and lower economic costs. Landfilling of energy-rich waste should be avoided as far as possible, partly because of the negative environmental impacts from landfilling, but mainly because of the low recovery of resources when landfilling. Differences between materials recycling, nutrient recycling and incineration are small but in general recycling of plastic is somewhat better than incineration and biological treatment somewhat worse. When planning waste management, it is important to know that the choice of waste treatment method affects processes outside the waste management system, such as generation of district heating, electricity, vehicle fuel, plastic, cardboard, and fertiliser.
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| 13. |
- Finnveden, Göran, et al.
(författare)
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Developing and evaluating new policy instruments for sustainable waste management
- 2012
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Ingår i: International Journal of Environment and Sustainable Development (IJESD). - 1474-6778 .- 1478-7466. ; 11:1, s. 19-31
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this paper is to suggest a number of interesting policy instruments that can make the Swedish waste management system more sustainable. Approximately 60 suggestions for policy instruments were gathered through a number of workshops with stakeholders. These were further prioritised in a workshop with stakeholders and by the research team resulting in a list of 15 instruments: information to citizens and companies; tax on raw materials; weight-based waste collection fee; environmentally differentiated waste collection fee; waste minimisation in enterprises; 'Advertising brochures - yes, please!'; recycling certificates; developed collection systems; tax on incineration of waste from fossil fuels; tax on incineration of waste; including waste in green certificates for electricity production; tax on hazardous substances; labelling of goods with hazardous substances; improved control by authorities; differentiated VAT and ban on incineration of recyclable materials. Several policy instruments are needed that can complement each other.
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- Sundqvist, J. O., et al.
(författare)
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MgI emission lines at 12 and 18 mu m in K giants
- 2008
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 486:3, s. 985-993
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Tidskriftsartikel (refereegranskat)abstract
- Context. The solar mid-infrared metallic emission lines have already been observed and analyzed well, and the formation scenario of the Mg I 12 mu m lines has been known for more than a decade. Detections of stellar emission at 12 mu m have, however, been limited to Mg I in very few objects. Previous modeling attempts have been made only for Procyon and two cool evolved stars, with unsatisfactory results for the latter. This prevents the lines' long predicted usage as probes of stellar magnetic fields. Aims. We want to explain our observed Mg I emission lines at 12 mu m in the K giants Pollux, Arcturus, and Aldebaran and at 18 mu m in Pollux and Arcturus. We discuss our modeling of these lines and particularly how various aspects of the model atom affect the emergent line profiles. Methods. High-resolution observational spectra were obtained using TEXES at Gemini North and the IRTF. To produce synthetic line spectra, we employed standard one-dimensional, plane-parallel, non-LTE modeling for trace elements in cool stellar atmospheres. We computed model atmospheres with the MARCS code, applied a comprehensive magnesium model atom, and used the radiative transfer code MULTI to solve for the magnesium occupation numbers in statistical equilibrium. Results. The Mg I emission lines at 12 mu m in the K giants are stronger than in the dwarfs observed so far. We present the first observed stellar emission lines from Mg I at 18 mu m and from Al I, Si I, and presumably Ca I at 12 mu m. We successfully reproduce the observed Mg I emission lines simultaneously in the giants and in the Sun, but show how the computed line profiles depend critically on atomic data input and how the inclusion of energy levels with n > ;= 10 and collisions with neutral hydrogen are necessary to obtain reasonable fits.
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- Unemo, Mats, 1970-, et al.
(författare)
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Clinical and analytical evaluation of the new Aptima Mycoplasma genitalium assay, with data on M. genitalium prevalence and antimicrobial resistance in M. genitalium in Denmark, Norway and Sweden in 2016
- 2018
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Ingår i: Clinical Microbiology and Infection. - : Elsevier. - 1198-743X .- 1469-0691. ; 24:5, s. 533-539
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: Mycoplasma genitalium (MG) causes urethritis and cervicitis, potentially causing reproductive complications. Resistance in MG to first-line (azithromycin) and second-line (moxifloxacin) treatment has increased. We examined the clinical and analytical performance of the new Conformite Europeene (CE)/in vitro diagnostics (IVD) Aptima Mycoplasma genitalium assay (CE/IVD AMG; Hologic); the prevalence of MG, Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG); and MG resistance to azithromycin and moxifloxacin in Denmark, Norway and Sweden in 2016.Methods: From February 2016 to February 2017, urogenital and extragenital (only in Denmark) specimens from consecutive attendees at three sexually transmitted disease clinics were tested with the CE/ IVD AMG, the research-use-only MG Alt TMA-1 assay (Hologic), Aptima Combo 2 (CT/NG) assay and a laboratory-developed TaqMan real-time mgpB quantitative real-time PCR (qPCR). Resistance-associated mutations were determined by sequencing. Strains of MG and other mycoplasma species in different concentrations were also tested.Results: In total 5269 patients were included. The prevalence of MG was 7.2% (382/5269; 4.9-9.8% in the countries). The sensitivity of the CE/IVD AMG, MG Alt TMA-1 and mgpB qPCR ranged 99.13-100%, 99.13 -100% and 73.24-81.60%, respectively, in the countries. The specificity ranged 99.57-99.96%, 100% and 99.69-100%, respectively. The prevalence of resistance-associated mutations for azithromycin and moxifloxacin was 41.4% (120/290; 17.7-56.6%) and 6.6% (18/274; 4.1-10.2%), respectively. Multidrug resistance was found in all countries (2.7%; 1.1-4.2%).Conclusions: Both transcription-mediated amplification (TMA)-based MG assays had a highly superior sensitivity compared to the mgpB qPCR. The prevalence of MG and azithromycin resistance was high. Validated and quality-assured molecular tests for MG, routine resistance testing of MG-positive samples and antimicrobial resistance surveillance are crucial.
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| 23. |
- Brandstrom, J., et al.
(författare)
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Basophil allergen threshold sensitivity and component-resolved diagnostics improve hazelnut allergy diagnosis
- 2015
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Ingår i: Clinical and Experimental Allergy. - : Wiley. - 0954-7894 .- 1365-2222. ; 45:9, s. 1412-1418
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundIgE sensitization to hazelnut is common, especially in birch endemic areas. However, its clinical significance often needs to be confirmed by a food challenge. ObjectiveTo evaluate the clinical significance of IgE antibodies to hazelnut components and basophil allergen threshold sensitivity (CD-sens) to hazelnut, in relation to double-blind placebo-controlled food challenge (DBPCFC) in children with a suspected hazelnut allergy. MethodsForty children underwent a DBPCFC. CD-sens to hazelnut as well as IgE antibodies to hazelnut and its components Cor a 1, Cor a 8, Cor a 9 and Cor a 14 were analysed. Serum tryptase was measured before, during and after DBPCFC. ResultsEight children had a positive DBPCFC, and all of them had a high CD-sens value to hazelnut. Of the 32 children that passed the DBPCFC, 31 were very low or negative in CD-sens. A positive DBPCFC corresponded with significantly higher CD-sens values (median 8.9, range 3.3-281) compared to children negative in challenge (median 0.05, range 0-34.7, P<0.0001). Children positive in challenge also had higher levels of IgE-ab to Cor a 9 and Cor a 14 (P<0.01 and P<0.001, respectively) compared with those with a negative challenge. In relation to the results from DBPCFC, the sensitivity of CD-sens and IgE-ab to Cor a 14 was excellent (100%) and the specificity was very high (>97% and >94%, respectively). Five of the eight patients positive at challenge showed an increase in tryptase >20% compared to tryptase baseline levels. Conclusions and Clinical RelevanceCD-sens and component-resolved diagnostics to hazelnut, used separately or in combination, may improve the diagnostic accuracy and safety and reduce overdiagnosis of hazelnut allergy.
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| 24. |
- Brandstrom, J., et al.
(författare)
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Individually dosed omalizumab : an effective treatment for severe peanut allergy
- 2017
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Ingår i: Clinical and Experimental Allergy. - : WILEY. - 0954-7894 .- 1365-2222. ; 47:4, s. 540-550
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Tidskriftsartikel (refereegranskat)abstract
- Background Treatment with omalizumab has shown a positive effect on food allergies, but no dosages are established. Basophil allergen threshold sensitivity (CD-sens) can be used to objectively measure omalizumab treatment efficacy and correlates with the outcome of double-blind placebo-controlled food challenge to peanut. Objective To evaluate whether individualized omalizumab treatment monitored by CD-sens could be an effective intervention for suppression of allergic reactions to peanut. Methods Severely peanut allergic adolescents (n = 23) were treated with omalizumab for 8 weeks, and CD-sens was analysed before and after. Based on whether CD-sens was suppressed after 8 weeks, the patients either were subject to a peanut challenge or received eight more weeks with increased dose of omalizumab, followed by peanut challenge or another 8-week cycle of omalizumab. IgE and IgE-antibodies to peanut and its components were analysed before treatment. Results After individualized omalizumab treatment (8-24 weeks), all patients continued with an open peanut challenge with no (n = 18) or mild (n = 5) objective allergic symptoms. Patients (n = 15) needing an elevated omalizumab dose (ED) to suppress CD-sens had significantly higher CD-sens values at baseline 1.49 (0.44-20.5) compared to those (n = 8) who managed with normal dose (ND) 0.32 (0.24-5.5) (P < 0.01). Median ratios for Ara h 2 IgE-ab/IgE were significantly higher in the ED group (17%) compared to the ND group (11%). Conclusions and Clinical Relevance Individually dosed omalizumab, monitored by CD-sens, is an effective and safe treatment for severe peanut allergy. The ratio of IgE-ab to storage protein Ara h 2/IgE as well as CD-sens to peanut may predict the need of a higher omalizumab dose.
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| 27. |
- Dalemo, M., et al.
(författare)
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ORWARE – A simulation model for organic waste handling systems. : Part 1: Model description
- 1997
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Ingår i: Resources, Conservation and Recycling. - 0921-3449 .- 1879-0658. ; 21:1, s. 17-37
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Tidskriftsartikel (refereegranskat)abstract
- A simulation model, ORWARE (ORganic WAste REsearch), for the handling of organic waste in urban areas has been constructed. The model provides a comprehensive view of the environmental effects, plant nutrient utilisation and energy turnover for this large and complex system. The ORWARE model consists of several sub-models; sewage plant, incineration, landfill, compost, anaerobic digestion, truck transport, transport by sewers, residue transport and spreading of residues on arable land. The model is intended for simulating different scenarios, and the results are: emissions to air and water, energy turnover and the amount of residues returned to arable land. All results are presented, both as the gross figure for the entire system and figures for each process. Throughout the model all physical flows are described by the same variable vector, consisting of 43 substances. This extensive vector facilitates a thorough analysis of the results, but involves some difficulties in acquiring relevant data. In this paper, the model is described. Results from a hypothetical case study are presented in a companion paper.
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| 30. |
- Finnveden, Göran, et al.
(författare)
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Policy Instruments towards a sustainable waste management
- 2016
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Ingår i: Solid waste management: Policy and planning for a sustainable society. - : Apple Academic Press. - 9781771883740 - 9780429091650 ; , s. 185-246, s. 185-246
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 34. |
- Montenegro, Marcelo F, et al.
(författare)
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Blood Pressure-Lowering Effect of Orally Ingested Nitrite Is Abolished by a Proton Pump Inhibitor.
- 2017
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Ingår i: Hypertension. - 0194-911X .- 1524-4563. ; 69:1, s. 23-31
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Tidskriftsartikel (refereegranskat)abstract
- Inorganic nitrate and nitrite from dietary and endogenous sources are metabolized to NO and other bioactive nitrogen oxides that affect blood pressure. The mechanisms for nitrite bioactivation are unclear, but recent studies in rodents suggest that gastric acidity may influence the systemic effects of this anion. In a randomized, double-blind, placebo-controlled crossover study, we tested the effects of a proton pump inhibitor on the acute cardiovascular effects of nitrite. Fifteen healthy nonsmoking, normotensive subjects, aged 19 to 39 years, were pretreated with placebo or esomeprazole (3×40 mg) before ingesting sodium nitrite (0.3 mg kg(-1)), followed by blood pressure monitoring. Nitrite reduced systolic blood pressure by a maximum of 6±1.3 mm Hg when taken after placebo, whereas pretreatment with esomeprazole blunted this effect. Peak plasma nitrite, nitrate, and nitroso species levels after nitrite ingestion were similar in both interventions. In 8 healthy volunteers, we then infused increasing doses of sodium nitrite (1, 10, and 30 nmol kg(-1) min(-1)) intravenously. Interestingly, although plasma nitrite peaked at similar levels as with orally ingested nitrite (≈1.8 µmol/L), no changes in blood pressure were observed. In rodents, esomeprazole did not affect the blood pressure response to the NO donor, DEA NONOate, or vascular relaxation to nitroprusside and acetylcholine, demonstrating an intact downstream NO-signaling pathway. We conclude that the acute blood pressure-lowering effect of nitrite requires an acidic gastric environment. Future studies will reveal if the cardiovascular complications associated with the use of proton pump inhibitors are linked to interference with the nitrate-nitrite-NO pathway.
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| 35. |
- Schiffer, Tomas A, et al.
(författare)
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Control of Human Energy Expenditure by Cytochrome C Oxidase Subunit IV-2.
- 2016
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Ingår i: American Journal of Physiology - Cell Physiology. - : American Physiological Society. - 0363-6143 .- 1522-1563. ; 311:3, s. C452-C461
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Tidskriftsartikel (refereegranskat)abstract
- Resting metabolic rate (RMR) in human shows pronounced individual variations, but the underlying molecular mechanism remains elusive. Cytochrome C oxidase (COX) plays a key role in control of metabolic rate and recent studies of the subunit 4 isoform 2 (COX IV-2) indicate involvement in the cellular response to hypoxia and oxidative stress. We evaluated whether the COX subunit IV isoform composition may explain the pronounced individual variations in resting metabolic rate (RMR). RMR was determined in healthy humans by indirect calorimetry and correlated to levels of COX IV-2 and COX IV-1 in Vastus Lateralis. Over expression and knock down of the COX IV isoforms were performed in primary myotubes followed by evaluation of the cell respiration and production of reactive oxygen species. Here we show that COX IV-2 protein is constitutively expressed in human skeletal muscle and strongly correlated to RMR. Primary human myotubes overexpressing COX IV-2 displayed markedly (>60%) lower respiration, reduced (>50%) cellular H2O2 production, higher resistance towards both oxidative stress and severe hypoxia compared to control cells. These results suggest an important role of isoform COX IV-2 in the control of energy expenditure, hypoxic tolerance and mitochondrial ROS homeostasis in humans.
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| 38. |
- Sundqvist, Michaela L, et al.
(författare)
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A randomized clinical trial of the effects of leafy green vegetables and inorganic nitrate on blood pressure.
- 2020
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Ingår i: American Journal of Clinical Nutrition. - : Oxford University Press. - 0002-9165 .- 1938-3207. ; 111:4, s. 749-756
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: A diet rich in fruits and vegetables is associated with lowering of blood pressure (BP), but the nutrient(s) responsible for these effects remain unclear. Research suggests that inorganic nitrate present in leafy green vegetables is converted into NO in vivo to improve cardiovascular function.OBJECTIVE: In this study, we evaluated the effect of leafy green vegetables on BP in subjects with elevated BP, with the aim of elucidating if any such effect is related to their high nitrate content.DESIGN: We enrolled 243 subjects, 50-70 y old, with a clinic systolic BP (SBP) of 130-159 mm Hg. After a 2-wk run-in period on a nitrate-restricted diet the subjects were randomly assigned to receive 1 of the following 3 interventions daily for 5 wk: low-nitrate vegetables + placebo pills, low-nitrate vegetables + nitrate pills (300 mg nitrate), or leafy green vegetables containing 300 mg nitrate + placebo pills. The primary end point measure was the difference in change in 24 h ambulatory SBP between the groups.RESULTS: A total of 231 subjects (95%) completed the study. The insignificant change in ambulatory SBP (mean ± standard deviation) was -0.6 ± 6.2 mm Hg in the placebo group, -1.2 ± 6.8 mm Hg in the potassium nitrate group, and -0.5 ± 6.6 mm Hg in the leafy green vegetable group. There was no significant difference in change between the 3 groups.CONCLUSIONS: A 5-wk dietary supplementation with leafy green vegetables or pills containing the same amount of inorganic nitrate does not decrease ambulatory SBP in subjects with elevated BP. This trial was registered at clinicaltrials.gov as NCT02916615.
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| 39. |
- Talyzin, Alexandr, et al.
(författare)
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Reaction of hydrogen gas with C60 at elevated pressure and temperature: Hydrogenation and cage fragmentation.
- 2006
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Ingår i: Journal of Physical Chemistry A. - : American Chemical Society (ACS). - 1089-5639 .- 1520-5215. ; 110:27, s. 8528-34
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Tidskriftsartikel (refereegranskat)abstract
- Products of the reaction of C60 with H2 gas have been monitored by high-resolution atmospheric pressurephotoionization Fourier transform ion cyclotron resonance mass spectrometry (APPI FT-ICR MS), X-raydiffraction, and IR spectroscopy as a function of hydrogenation period. Samples were synthesized at 673 Kand 120 bar hydrogen pressure for hydrogenation periods between 300 and 5000 min, resulting in the formationof hydrofullerene mixtures with hydrogen content ranging from 1.6 to 5.3 wt %. Highly reduced C60Hx (x >36-40) and products of their fragmentation were identified in these samples by APPI FT-ICR MS. A sharpchange in structure was observed for samples with at least 5.0 wt % of hydrogen. Low-mass (300-500 Da)hydrogenation products not observed by prior field desorption (FD) FT-ICR MS were detected by APPIFT-ICR MS and their elemental compositions obtained for the first time. Synthetic and analytical fragmentationpathways are discussed.
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