| 1. |
- Bengtsson, Kenneth, et al.
(författare)
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Så kan Sverige bli ledande nation i resurseffektivitet
- 2016
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Ingår i: Dagens Nyheter. - 1101-2447. ; :2016-04-30
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Ny rapport. Det svenska näringslivet kan bli mer hållbart, resurssmart och därmed internationellt konkurrenskraftigt. Men för det behövs en tydlig politisk avsiktsförklaring och riktlinjer. Vi har listat sex områden där policyutveckling brådskar, skriver företrädare för näringsliv, forskning och myndigheter i en gemensam uppmaning.
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| 2. |
- Hansson, L-A, et al.
(författare)
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A synthesis of animal movement across scales
- 2014
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Ingår i: Animal Movement Across Scales. - : Oxford University Press. - 9780199677184 ; , s. 259-267
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Bokkapitel (refereegranskat)abstract
- This chapter aims at synthesizing the knowledge presented in the chapters of the book’s three sections by addressing evolutionary compromises, dispersal, gene flow, and assisted movements. How climate change and other environmental changes at different scales may affect animal movement, migration, and dispersal in the future are also summarized here. Moreover, how the different senses are utilized for navigation and orientation and how these may lead to different movement and migration patterns are also discussed. Finally, how the recent technical revolution has affected animal movement research is addressed and the view on future perspectives of animal movement research is also provided.
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| 3. |
- Luu, Henrik, et al.
(författare)
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Curettage and electrodessication combined with photodynamic therapy in the treatment of large squamous cell carcinomas in unfit and frail patients
- 2022
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Ingår i: BMJ Case Reports. - : BMJ. - 1757-790X. ; 15:6
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Tidskriftsartikel (refereegranskat)abstract
- A Caucasian female patient in her 90s was referred to the department of plastic and reconstructive surgery for surgical removal of a large invasive squamous cell carcinoma on the anterior chest wall. A skin biopsy prior to the referral indicated that the tumour was moderately differentiated. The patient suffered from severe congestive heart failure with a mechanical valve prosthesis and atrial fibrillation, and was therefore treated with anticoagulants. Hence, a surgical procedure would be hazardous. Therefore, other treatment options were considered. The principal aim was to reduce the amount of tumour tissue to an appropriate size suitable for later excision with primary wound closure. After interdisciplinary discussions, curettage and electrodessication combined with photodynamic therapy was judged the best alternative treatment in this case. At the 1.5 years follow-up after the intervention there was no indication for further surgery. The patient was at that stage content with the treatment and its outcome.
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| 4. |
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| 5. |
- Nyrén, Miruna, et al.
(författare)
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Influence of childhood atopic dermatitis on future worklife.
- 2005
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Ingår i: Scandinavian Journal of Work, Environment and Health. - : Scandinavian Journal of Work, Environment and Health. - 0355-3140 .- 1795-990X. ; 31:6, s. 474-478
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Tidskriftsartikel (refereegranskat)
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| 6. |
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| 7. |
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| 8. |
- Tyler, Torbjörn, et al.
(författare)
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Utsådda blommor räddar inte insekterna
- 2021
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Ingår i: Svenska Dagbladet. - 1101-2412.
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Om vi vill rädda hotade insektsarter är det miljöer med traditionella ängsväxter som vi behöver mer av, inte fröblandningar av oklart ursprung från handeln. Det skriver flera debattörer.
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| 9. |
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| 10. |
- Aasa, Mikael, et al.
(författare)
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Cost and health outcome of primary percutaneous coronary intervention versus thrombolysis in acute ST-segment elevation myocardial infarction-Results of the Swedish Early Decision reperfusion Study (SWEDES) trial.
- 2010
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Ingår i: American heart journal. - : Elsevier BV. - 1097-6744 .- 0002-8703. ; 160:2, s. 322-8
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: In ST-elevation myocardial infarction, primary percutaneous coronary intervention (PCI) has a superior clinical outcome, but it may increase costs in comparison to thrombolysis. The aim of the study was to compare costs, clinical outcome, and quality-adjusted survival between primary PCI and thrombolysis. METHODS: Patients with ST-elevation myocardial infarction were randomized to primary PCI with adjunctive enoxaparin and abciximab (n = 101), or to enoxaparin followed by reteplase (n = 104). Data on the use of health care resources, work loss, and health-related quality of life were collected during a 1-year period. Cost-effectiveness was determined by comparing costs and quality-adjusted survival. The joint distribution of incremental costs and quality-adjusted survival was analyzed using a nonparametric bootstrap approach. RESULTS: Clinical outcome did not differ significantly between the groups. Compared with the group treated with thrombolysis, the cost of interventions was higher in the PCI-treated group ($4,602 vs $3,807; P = .047), as well as the cost of drugs ($1,309 vs $1,202; P = .001), whereas the cost of hospitalization was lower ($7,344 vs $9,278; P = .025). The cost of investigations, outpatient care, and loss of production did not differ significantly between the 2 treatment arms. Total cost and quality-adjusted survival were $25,315 and 0.759 vs $27,819 and 0.728 (both not significant) for the primary PCI and thrombolysis groups, respectively. Based on the 1-year follow-up, bootstrap analysis revealed that in 80%, 88%, and 89% of the replications, the cost per health outcome gained for PCI will be <$0, $50,000, and $100,000 respectively. CONCLUSION: In a 1-year perspective, there was a tendency toward lower costs and better health outcome after primary PCI, resulting in costs for PCI in comparison to thrombolysis that will be below the conventional threshold for cost-effectiveness in 88% of bootstrap replications.
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| 11. |
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| 12. |
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| 13. |
- Aggarwal, MM, et al.
(författare)
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Centrality and transverse momentum dependence of collective flow in 158 A GeV Pb+Pb collisions measured via inclusive photons
- 2005
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Ingår i: Nuclear Physics, Section A. - : Elsevier BV. - 0375-9474. ; 762:1-2, s. 129-146
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Tidskriftsartikel (refereegranskat)abstract
- Directed and elliptic flow of inclusive photons near mid-rapidity in 158 A GeV Pb + Pb collisions has been studied. The data have been obtained with the photon spectrometer LEDA of the WA98 experiment at the CERN SPS. The flow strength has been measured for various centralities as a function of p(T) and rapidity over 0. 18 < p(T) < 1.5 GeV/c and 2.3 < y < 2.9. The angular anisotropy has been studied relative to an event plane obtained in the target fragmentation region that shows the elliptic flow to be in-plane. The elliptic flow has also been studied using two-particle correlations and shown to give similar results. A small directed flow component is observed. Both the directed and elliptic flow strengths increase with p(T). The photon flow results are used to estimate the corresponding neutral pion flow.
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| 14. |
- Aggarwal, MM, et al.
(författare)
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Centrality dependence of charged-neutral particle fluctuations in 158A (GeVPb)-Pb-208+Pb-208 collisions
- 2003
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Ingår i: Physical Review C (Nuclear Physics). - 0556-2813. ; 67:4
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Tidskriftsartikel (refereegranskat)abstract
- Results on the study of localized fluctuations in the multiplicity of charged particles and photons produced in 158A GeV/c Pb+Pb collisions are presented for varying centralities. The charged versus neutral particle multiplicity correlations in common phase space regions of varying azimuthal sizes are analyzed by two different methods. Various types of mixed events are constructed to probe fluctuations arising from different sources. The measured results are compared to those from simulations and from mixed events. The comparison indicates the presence of nonstatistical fluctuations in both the charged particle and photon multiplicities in limited azimuthal regions. However, no correlated charged-neutral fluctuations, a possible signature of formation of disoriented chiral condensates, are observed. An upper limit on the production of disoriented chiral condensates is set.
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| 15. |
- Aggarwal, MM, et al.
(författare)
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Event-by-event fluctuations in particle multiplicities and transverse energy produced in 158A GeVPb plus Pb collisions
- 2002
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Ingår i: Physical Review C (Nuclear Physics). - 0556-2813. ; 65:5
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Tidskriftsartikel (refereegranskat)abstract
- Event-by-event fluctuations in the multiplicities of charged particles and photons, and the total transverse energy in 158A GeV Pb+Pb collisions are studied for a wide range of centralities. For narrow centrality bins the multiplicity and transverse energy distributions are found to be near perfect Gaussians. The effect of detector acceptance on the multiplicity fluctuations has been studied and demonstrated to follow statistical considerations. The centrality dependence of the charged particle multiplicity fluctuations in the measured data has been found to agree reasonably well with those obtained from a participant model. However, for photons the multiplicity fluctuations have been found to be lower compared to those obtained from a participant model. The multiplicity and transverse energy fluctuations have also been compared to those obtained from the VENUS event generator.
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| 16. |
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| 17. |
- Aggarwal, M M, et al.
(författare)
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Azimuthal anisotropy of photon and charged particle emission in Pb-208+Pb-208 collisions at 158 center dot A GeV/c
- 2005
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 41:3, s. 287-296
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Tidskriftsartikel (refereegranskat)abstract
- The azimuthal distributions of photons and charged particles with respect to the event plane are investigated as a function of centrality in Pb-208 + Pb-208 collisions at 158 (.) A GeV/c in the WA98 experiment at the CERN SPS. The anisotropy of the azimuthal distributions is characterized using a Fourier analysis. For both the photon and charged particle distributions the first two Fourier coefficients are observed to decrease with increasing centrality. The observed anisotropies of the photon distributions compare well with the expectations from the charged particle measurements for all centralities.
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| 18. |
- Aggarwal, M. M., et al.
(författare)
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Event-by-event charged-neutral fluctuations in Pb plus Pb collisions at 158 A GeV
- 2011
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 701:3, s. 300-305
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Tidskriftsartikel (refereegranskat)abstract
- Charged particles and photons have been measured in central Pb + Pb collisions at 158 A GeV in a common (eta-phi)-phase space region in the WA98 experiment at the CERN SPS. The measured distributions have been analyzed to quantify the frequency with which phase space regions of varying sizes have either small or large neutral pion fraction. The measured results are compared with VENUS model simulated events and with mixed events. Events with both large and small charged-neutral fluctuations are observed to occur more frequently than expected statistically, as deduced from mixed events, or as predicted by model simulations, with the difference becoming more prominent with decreasing size of the A Delta eta-Delta phi region. (C) 2011 Elsevier B.V. All rights reserved.
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| 19. |
- Aggarwal, M. M., et al.
(författare)
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Photon and eta production in p plus Pb and p plus C collisions at root(NN)-N-S=17.4 GeV
- 2013
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Ingår i: Nuclear Physics, Section A. - : Elsevier BV. - 0375-9474. ; 898, s. 14-23
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Tidskriftsartikel (refereegranskat)abstract
- Measurements of direct photon production in p + Pb and p + C collisions at root(NN)-N-s = 17.4 GeV are presented. Upper limits on the direct photon yield as a function of p(T) are derived and compared to the results for Pb + Pb collisions at root(NN)-N-s = 17.3 GeV. The production of the eta meson, which is an important input to the direct photon signal extraction, has been determined in the eta -> 2 gamma channel for p + C collisions at root(NN)-N-s = 17.4 GeV. (c) 2012 Elsevier B.V. All rights reserved.
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| 20. |
- Aggarwal, M. M., et al.
(författare)
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Pion freeze-out time in Pb plus Pb collisions at 158 AGeV/c studied via pi(-)/pi(+) and K-/K+ ratios
- 2006
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 48:2, s. 343-352
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Tidskriftsartikel (refereegranskat)abstract
- The effect of the final state Coulomb interaction on particles produced in Pb + Pb collisions at 158AGeV/c has been investigated in the WA98 experiment through the study of the pi(-)/pi(+) and K-/K+ ratios measured as a function of T-m- (m)0. While the ratio for kaons shows no significant T-m dependence, the pi(-)/pi(+) ratio is enhanced at small T-m - (m)0 values with an enhancement that increases with centrality. A silicon pad detector located near the target is used to estimate the contribution of hyperon decays to the pi(-)/pi(+) ratio. The comparison of results with predictions of the RQMD model in which the Coulomb interaction has been incorporated allows to place constraints on the time of the pion freeze-out.
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| 21. |
- Aggarwal, M. M., et al.
(författare)
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Suppression of high-p(T) neutral pion production in central Pb+Pb collisions at root s(NN)=17.3 GeV relative to p+C and p+Pb collisions
- 2008
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Ingår i: Physical Review Letters. - 1079-7114. ; 100:24
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Tidskriftsartikel (refereegranskat)abstract
- Neutral pion transverse momentum spectra were measured in p+C and p+Pb collisions at root s(NN) = 17.4 GeV at midrapidity (2.3 less than or similar to eta(lab)less than or similar to 3.0) over the range 0.7 less than or similar to p(T)less than or similar to 3.5 GeV/c. The spectra are compared to pi(0) spectra measured in Pb+Pb collisions at root s(NN) = 17.3 GeV in the same experiment. For a wide range of Pb+Pb centralities (N-part less than or similar to 300), the yield of pi(0)'s with p(T)greater than or similar to 2 GeV/c is larger than or consistent with the p+C or p+Pb yields scaled with the number of nucleon-nucleon collisions (N-coll), while for central Pb+Pb collisions with N-part greater than or similar to 350, the pi(0) yield is suppressed.
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| 22. |
- Aggarwal, MM, et al.
(författare)
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Transverse mass distributions of neutral pions from Pb-208-induced reactions at 158 center dot A GeV
- 2002
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 23:2, s. 225-236
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Tidskriftsartikel (refereegranskat)abstract
- Results on transverse mass spectra of neutral pious measured at central rapidity are presented for impact parameter selected 158-A GeV Pb + Pb-1 and Pb + Nb collisions. The distributions cover the range 0.5 GeV/c(2) less than or equal to MT - Mo less than or equal to 4 GeV/c(2). The change of the spectral shape and the multiplicity with centrality is studied in detail. In going from p+p to semi-peripheral Pb+Pb collisions there is a nuclear enhancement increasing with transverse mass similar to the well known Cronin effect, while for very central collisions this enhancement appears to be weaker than expected.
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| 23. |
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| 24. |
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| 25. |
- Ahrné, Karin, et al.
(författare)
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Dagfjärilar i naturbetesmarker, kraftledningsgator, på hyggen och skogsbilvägar : betydelse för miljöövervakning
- 2011
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Ett förändrat och intensifierat jordbruk har bland annat lett till att naturbetesmarker och andra gräsmarksbiotoper minskat i odlingslandskapet. Detta har fått till följd att många arter knutna till öppna gräsmarker minskat, däribland fåglar, växter och dagfjärilar. Dagfjärilar svarar snabbt på förändringar både i miljön och klimatet och kan därför vara viktiga indikatorarter för miljöövervakning. I år startar en nationell övervakning av dagfjärilar med hjälp av volontärer och de senaste fem åren har dagfjärilar inventerats i ängs- och betesmarker inom den nationella inventeringen av landskapet (NILS). För att få en rättvisande bild av hur situationen ser ut för dagfjärilar i Sverige kan det vara viktigt att systematiskt inventera olika typer av miljöer, inte enbart ängs- och betesmarker eller känt artrika platser. I den här studien jämför vi artrikedom, individantal och artsammansättning av dagfjärilar (Rophalocera) och bastardsvärmare (Zyganidaea) i naturbetesmarker och tre typer av öppna biotoper i skogslandskapet; hyggen, kraftledningsgator och skogsbilvägar. Vi delar också in fjärilarna efter val av värdväxt och flygtid på säsongen för att se om det finns några skillnader mellan biotoperna vad gäller art- och individrikedom inom dessa grupper. Vi undersöker hur mängden skog och betesmark inom det omgivande landskapet påverkar dagfjärilsfaunan på de olika platserna och hur många inventeringstillfällen (3, 5 eller 7) som krävs för att få tillförlitliga data på artrikedomen på en plats. Våra resultat visar att artsammansättningen av fjärilar skiljer sig mellan biotoperna och att alla bidrar med unika arter och således kompletterar varandra. Kraftledningsgatorhade både fler fjärilsarter och individer än de övriga biotoperna och hyggen och skogsbilvägar var lika art- och individrika som betesmarkerna. Det är därför viktigt att övervaka flera typer av miljöer och även skogsbiotoper inom framtida dagfjärilsövervakning. Eftersom alla tre skogsbiotoperna hyser en stor mångfald av fjärilar kan det vara värt att anpassa skötseln av dessa miljöer för att gynna fjärilar. I kraftledningsgator och skogsbilvägar som är relativt beständiga miljöer och som redan idag sköts med ett visst intervall är detta fullt möjligt. Betydelsen av antal inventeringstillfällen beror på vilken frågeställning man har. Vill man jämföra artrikedomen i olika miljöer eller studera förändring i artrikedom mellan år kan det kanske räcka med tre besök, men vill man ha en mer heltäckande bild av artrikedomen på en plats kan det sju eller fler besök spridda över säsongen
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| 26. |
- Akerstrom, Ulf, et al.
(författare)
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Comparison of Moisturizing Creams for the Prevention of Atopic Dermatitis Relapse: A Randomized Double-blind Controlled Multicentre Clinical Trial
- 2015
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Ingår i: Acta Dermato-Venereologica. - : Medical Journals Sweden AB. - 1651-2057 .- 0001-5555. ; 95:5, s. 587-592
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Tidskriftsartikel (refereegranskat)abstract
- Atopic dermatitis (AD) affects adults and children and has a negative impact on quality of life. The present multicentre randomized double-blind controlled trial showed a barrier-improving cream (5% urea) to be superior to a reference cream in preventing eczema relapse in patients with AD (hazard ratio 0.634, p = 0.011). The risk of eczema relapse was reduced by 37% (95% confidence interval (95% CI) 10-55%). Median time to relapse in the test cream group and in the reference cream group was 22 days and 15 days, respectively (p = 0.013). At 6 months 26% of the patients in the test cream group were still eczema free, compared with 10% in the reference cream group. Thus, the barrier-improving cream significantly prolonged the eczema-free time compared with the reference cream and decreased the risk of eczema relapse. The test cream was well tolerated in patients with AD.
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| 27. |
- Alhadad, Alaa, et al.
(författare)
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Erythromelalgia: Incidence and clinical experience in a single centre in Sweden.
- 2012
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Ingår i: Vasa: European Journal of Vascular Medicine. - : Hogrefe Publishing Group. - 0301-1526. ; 41:1, s. 43-48
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Tidskriftsartikel (refereegranskat)abstract
- Background: Erythromelalgia (EM) incidence has not been well studied and there are only two studies published on this subject as far as we know. The aims are to study the incidence of this rare condition in the south of Sweden, to report the clinical experience from a single centre including characterisation of comorbidity and to report on prognosis. Patients and methods: Retrospective study of a population-based analysis of data from the southernmost part of Sweden corresponding to the median age of the patients (Statistics Sweden). The diagnosis of EM is based on the medical record reflecting the triad of redness, burning pain and increased temperature of the feet or hands or both. We evaluated the presence or absence of EM triad by recording the history, physical examination, laboratory analysis, cold provocation test and laser Doppler imaging, and by searching for any confounding disease in cases of suspected EM. Results: During a 10.5 year period we clinically identified 27 patients with EM. Median age was 49 [IQR (34 - 68)] years, 19 (70 %) were women. The mean delay from the onset of the symptoms to the time of diagnosis was 4.5 (SD ± 3.9) years. Gender and age adjusted incidence of EM for our region was calculated to be 0.36 per 100 000 persons per year. Three patients developed intraabdominal cancer during the follow up, but there was no mortality directed related to EM. Conclusions: The overall population-based incidence of erythromelalgia was 0.36 per 100 000 which is identical with a previous report in a Scandinavian population.
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| 28. |
- Alhadad, Alaa, et al.
(författare)
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Incidence of nephrogenic systemic fibrosis at a large university hospital in Sweden.
- 2012
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Ingår i: Scandinavian Journal of Urology and Nephrology. - : Informa UK Limited. - 1651-2065 .- 0036-5599. ; 46, s. 48-53
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Tidskriftsartikel (refereegranskat)abstract
- Objective. Nephrogenic systemic fibrosis (NSF) is a rare condition that may follow administration of gadolinium-based contrast media (Gd-CM) in patients with renal insufficiency. This study was initiated to determine the incidence of NSF at Skåne University Hospital, Malmö, in Sweden. Material and methods. During the period January 2001 to December 2008 10 650 patients underwent magnetic resonance imaging (MRI) examinations. The re-expressed four-variable Modification of Diet in Renal Disease (MDRD) equation was used to calculate the estimated glomerular filtration rate (eGFR). The 272 patients with an eGFR <30 ml/min/1.73 m2 who were given Gd-CM were selected for final analysis. A diagnosis of NSF or other dermatological diagnoses in the 272 patients was searched for in the database of the Departments of Dermatology and Pathology. Results. The 272 patients, of whom 26 patients were on dialysis, had undergone 406 MRI examinations with Gd-CM. Mean follow-up time was 3.9 (±2.7 SD) years. Assuming a mean body weight of 70 kg, the overall median dose of the 406 examinations with Gd-CM was 0.14 mmol/kg body weight (0.06, 0.34; 2.5-97.5 percentiles). In this retrospective study of patients with eGFR <30 ml/min/1.73 m(2), none developed NSF (the upper 95% confidence limit for zero cases of NSF in the 272 patients was 2.3%). Conclusion. Although it is premature to claim that Gd-CM using the regimen employed in this institution is safe to use in all patients with eGFR <30 ml/min/1.73 m(2), the results.indicate that development of NSF is extremely uncommon.
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| 29. |
- Allander, Susanne Vilhelmsdotter, et al.
(författare)
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Kreatinin fortfarande den vanligaste njurfunktionsanalysen : Undersökning av praxis i Sverige
- 2012
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Ingår i: Läkartidningen. - 0023-7205 .- 1652-7518. ; 109:19, s. 960-962
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Tidskriftsartikel (refereegranskat)abstract
- Markers of renal function (glomerular filtration rate; GFR) are frequently used. In most cases GFR is estimated based on plasma creatinine, but cystatin C, creatinine clearance (with urine collection), iohexol clearance and 51Cr-EDTA clearance are also used. A questionnaire was sent to representatives for clinical chemistry laboratories in Sweden to collect information regarding the use of these markers during the years 2006 2009. The aim was to compare the use in different parts of Sweden and how it has changed over time. The overall use of markers of renal function, including creatinine, continues to increase on a national level, with the exception for endogenous creatinine clearance and 51Cr-EDTA clearance. Creatinine, the most frequently used marker, continues to grow in numbers. 5,6 million creatinine analyses and about two hundred thousand cystatin C analyses were performed during year 2009. There were considerable variations between counties in the use of the studied markers.
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| 30. |
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| 31. |
- Alsterholm, Mikael, 1977, et al.
(författare)
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Establishment and utility of SwedAD : a nationwide Swedish registry for patients with atopic dermatitis receiving systemic pharmacotherapy
- 2023
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Ingår i: Acta Dermato-Venereologica. - : Medical Journals Sweden AB. - 0001-5555 .- 1651-2057. ; 103
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Tidskriftsartikel (refereegranskat)abstract
- SwedAD, a Swedish nationwide registry for patients with atopic dermatitis receiving systemic pharmacotherapy, was launched on 1 September 2019. We describe here the establishment of a user-friendly registry to the benefit of patients with atopic dermatitis. By 5 November 2022, 38 clinics had recorded 931 treatment episodes in 850 patients with an approximate national coverage rate of 40%. Characteristics at enrolment included median Eczema Area and Severity Index (EASI) 10.2 (interquartile range 4.0, 19.4), Patient-Oriented Eczema Measure (POEM) 18.0 (10.0, 24.0), Dermatology Life Quality Index (DLQI) 11.0 (5.0, 19.0) and Peak Itch Numerical Rating Scale-11 (NRS-11) 6.0 (3.0, 8.0). At 3 months, median EASI was 3.2 (1.0, 7.3) and POEM, DLQI, and NRS-11 were improved. Regional coverage varied, reflecting the distribution of dermatologists, the ratio of public to private healthcare, and difficulties in recruiting certain clinics. This study highlights the importance of a nationwide registry when managing systemic pharmacotherapy of atopic dermatitis.
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| 32. |
- Andersen, Marie Louise M., et al.
(författare)
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Association between autoantibodies to the Arginine variant of the Zinc transporter 8 (ZnT8) and stimulated C-peptide levels in Danish children and adolescents with newly diagnosed type 1 diabetes
- 2012
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Ingår i: Pediatric Diabetes. - : Hindawi Limited. - 1399-543X .- 1399-5448. ; 13:6, s. 454-462
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Tidskriftsartikel (refereegranskat)abstract
- Background The zinc transporter 8 (ZnT8) was recently identified as a common autoantigen in type 1 diabetes (T1D) and inclusion of ZnT8 autoantibodies (ZnT8Ab) was found to increase the diagnostic specificity of T1D. Objectives The main aims were to determine whether ZnT8Ab vary during follow-up 1 year after diagnosis, and to relate the reactivity of three types of ZnT8Ab to the residual stimulated C-peptide levels during the first year after diagnosis. Subjects A total of 129 newly diagnosed T1D patients <15 years was followed prospectively 1, 3, 6, and 12 months after diagnosis. Methods Hemoglobin A1c, meal-stimulated C-peptide, ZnT8Ab, and other pancreatic autoantibodies were measured at each visit. Patients were genotyped for the rs13266634 variant at the SLC30A8 gene and HLA-DQ alleles. Results The levels of all ZnT8Ab [ZnT8Arg (arginine), ZnT8Trp (tryptophan), ZnT8Gln (glutamine)] tended to decrease during disease progression. A twofold higher level of ZnT8Arg and ZnT8Gln was associated with 4.6%/5.2% (p = 0.02), 5.3%/8.2% (p = 0.02) and 8.9%/9.7% (p = 0.004) higher concentrations of stimulated C-peptide 3, 6, and 12 months after diagnosis. The TT genotype carriers of the SLC30A8 gene had 45.8% (p = 0.01) and 60.1% (p = 0.002) lower stimulated C-peptide 6 and 12 months after diagnosis compared to the CC and the CT genotype carriers in a recessive model. Conclusions The levels of the Arg variant of the ZnT8 autoantibodies are associated with higher levels of stimulated C-peptide after diagnosis of T1D and during follow-up. Carriers of the TT genotype of the SLC30A8 gene predict lower stimulated C-peptide levels 12 months after diagnosis.
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| 33. |
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| 34. |
- Anna T, Danielsson, 1978-, et al.
(författare)
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Power and Knowledge in the Technology Classroom : The Development and Illustration of a Conceptual Framework
- 2014
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Konferensbidrag (refereegranskat)abstract
- This paper explores the constitution of power and knowledge in science and technology classrooms. A deepened examination of the teaching of science and technology is partly motivated by these subjects high status in society, how they portrayed as crucial both for the individual, in order to function in an increasingly technologically advanced society, and for the society at large, while finding it increasingly difficult to attract interest among the youth. In the Swedish context, where this research is carried out, it can further be noted that while the country is top-ranked on a number of equality indices and in general has a reputation that highlights its commitment to eradicating social inequalities, the labour market is still highly gender segregated and in university educations focused on the physical sciences and engineering men are substantially overrepresented (Nyström 2009, Alexandersson 2011). This somewhat paradoxical situation further motivates studies of how science and technology are constructed in and beyond the classroom in Sweden, since often cited reasons to women's underrepresentation in science and technology in, for example, the U.S., such as the legislation regarding parental leave and the tenure clock (Rosser 2012), is much less applicable to the Swedish context. In our research project we take a particular interest in a period where research show that many students lose interest in science and technology, namely the last years of compulsory schooling (cf. Lindahl 2003, Archer et al. 2010). By a deepened exploration of how power and knowledge interrelate in moment-to-moment interactions in the classroom we therefore hope to provide some additional clues as to how micro-inequalities, adding up to patterns of exclusion in science and technology (Rosser 2012), occur in the classroom context.The aim of this paper is to develop and illustrate the use of a conceptual framework for exploring how power relations are constituted in the technology classroom – in terms of what Foucault (1982/2002) conceptualises as 'actions upon actions' (p. 340) – by the research questions:1) How are teacher actions communicating how and what knowledge is privileged in the classroom?2) How is this knowledge privileging establishing power relations, in terms of possibilities for student actions?
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| 35. |
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| 36. |
- Aronson, Åke, et al.
(författare)
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Ulv i Skandinavia : Statusrapport for vinteren 2009-2010
- 2010
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The wolves in Sweden and Norway are members of a joint Scandinavian wolf population. In a combined Swedish-Norwegian monitoring project, wolves on the Scandinavian Peninsula were located and counted during the winter of 2009-2010. In Sweden, County administrative boards perform the fieldwork and collection of field data (snow-tracking, DNA-samples), whereas the Wildlife Damage Center (VSC) at Grimsö Research Station was responsible for evaluating and summarizing the results of the wolf monitoring. In Norway, wolf biologists at Hedmark University College and a genetist at Rovdata (Trondheim) in cooperation with the Norwegian Nature Inspectorate (SNO) were responsible for the monitoring of resident and non-resident wolves, respectively. Furthermore, cooperative wolf pack monitoring has been carried out in Fennoscandia in collaboration with Finland. A large number of volunteers and organizations such as hunting associations in both countries and the Swedish Carnivore Association also report observations and participate in wolf monitoring activities. The estimated number of wolves in Scandinavia is mainly based on long distances of ground tracking on snow, but also by radio-telemetry and DNA-analysis. The estimate was restricted to the period of October 1, 2009 – February 28, 2010. To guarantee the quality of the reports used, the majority have been checked in the field by the project, or by other personnel with experience of ground tracking wolves on snow. Wolves were classified as 1) family groups (packs), 2) scent-marking pairs, 3) other resident wolves, or 4) other wolves. The results were presented as minimum-maximum numbers where the minimum was exclusively based on confirmed field-checked reports, while the maximum also included other reports. A total of 252-291 wolves were estimated on the Scandinavian Peninsula during the 2009-2010 winter. Among these, 28 packs included 165-175 wolves, and 44-49 wolves belonged to 21-24 scent-marking pairs. The majority of the wolves (186-215) were located in Sweden. Of the 33-39 wolves restricted to Norway, 21-23 were members of 3 packs, 6 were scent-marking pair members, none were classified as “other resident wolves”, and 6-10 were classified as “other wolves”. Areas were utilized on both sides of the national border between Sweden and Norway by 33-37 resident wolves. Successful reproduction in the spring of 2009 was confirmed in 26 of the Scandinavian wolf territories. Among these, 19 litters were born in Sweden, 4 litters was born in a transboundary packs, and 3 litters grew up in Norway. In 2009, two Finnish-Russian male wolves reproduced for the second time, one litter in Sweden (the Galven territory) and one in Norway (the Kynna territory). In Finland, during the winter 2009-10, a total of 76-78 wolves in 15 packs were estimated to have exclusively Finnish territories. In addition 72-74 wolves were pack members within 13 territories across the Finnish-Russian border
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| 37. |
- Aronson, Åke, et al.
(författare)
-
Ulv i Skandinavia : statusrapport for vinteren 2010-2011
- 2011
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The wolves in Sweden and Norway are members of a joint Scandinavian wolf population. In a combined Swedish-Norwegian monitoring project, wolves on the Scandinavian Peninsula were located and counted during the winter of 2010-2011. In Sweden, County administrative boards perform the fieldwork and collection of field data (snow-tracking, DNA-samples), whereas the Wildlife Damage Center (VSC) at Grimsö Research Station was responsible for evaluating and summarizing the results of the wolf monitoring. In Norway, wolf biologists at Hedmark University College and a genetist at Rovdata (Trondheim) in cooperation with the Norwegian Nature Inspectorate (SNO) were responsible for the monitoring of resident and non-resident wolves, respectively. Furthermore, cooperative wolf pack monitoring has been carried out in Fennoscandia in collaboration with Finland. A large number of volunteers and organizations such as hunting associations in both countries and the Swedish Carnivore Association also report observations and participate in wolf monitoring activities. The estimated number of wolves in Scandinavia is mainly based on long distances of ground tracking on snow, but also by DNA-analysis and radio-telemetry. The estimate was restricted to the period of October 1, 2010 – February 28, 2011. To guarantee the quality of the reports used, the majority have been checked in the field by the project, or by other personnel with experience of ground tracking wolves on snow. Wolves were classified as 1) family groups (packs), 2) scent-marking pairs, 3) other resident wolves, or 4) other wolves. The results were presented as minimum-maximum numbers where the minimum was exclusively based on confirmed field-checked reports, while the maximum also included other reports. A total of 289-325 wolves were estimated on the Scandinavian Peninsula during the 2010-2011 winter. Among these, 31 packs included 183-189 wolves, and 57-61 wolves belonged to 27-30 scent-marking pairs. The majority of the wolves (235-266) were located in Sweden, of which 149-154 were members of 25 packs, 43-44 lived in 20-22 scent-marking pairs, 4 were classified as “other resident wolves”, and 39-64 were classified as “other wolves”. Of the 32-34 wolves restricted to Norway, 18-19 were members of 3 packs, 8 were scent-marking pair members, one was classified as “other resident wolves”, and 5-6 were classified as “other wolves”. Another 22-25 resident wolves lived in 6-7 packs or scent-marking pairs in territories covering areas on both sides of the Swedish-Norwegian border. Successful reproduction in spring 2010 was confirmed in 31 of the Scandinavian wolf territories. Among these, 25 litters were born in Sweden, 3 litters were born in transboundary packs, and 3 litters grew up in Norway. In 2010, two Finnish-Russian male wolves reproduced for the third time, one litter in Sweden (the Galven territory) and one in Norway (the Kynna territory). In Finland, during the winter 2010-11, a total of 48 wolves in 8 packs were estimated to have exclusively Finnish territories. In addition 59-64 wolves were pack members within 11 territories across the Finnish-Russian border
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| 38. |
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| 39. |
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| 40. |
- Barbosa, Edna J L, 1961, et al.
(författare)
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Extracellular water and blood pressure in adults with growth hormone (GH) deficiency: a genotype-phenotype association study.
- 2014
-
Ingår i: PloS one. - : Public Library of Science (PLoS). - 1932-6203. ; 9:8
-
Tidskriftsartikel (refereegranskat)abstract
- Growth hormone deficiency (GHD) in adults is associated with decreased extracellular water volume (ECW). In response to GH replacement therapy (GHRT), ECW increases and blood pressure (BP) reduces or remains unchanged. Our primary aim was to study the association between polymorphisms in genes related to renal tubular function with ECW and BP before and 1 year after GHRT. The ECW measures using bioimpedance analysis (BIA) and bioimpedance spectroscopy (BIS) were validated against a reference method, the sodium bromide dilution method (Br(-)).
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| 41. |
- Barbosa, Edna J L, 1961, et al.
(författare)
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Genotypes associated with lipid metabolism contribute to differences in serum lipid profile of GH-deficient adults before and after GH replacement therapy.
- 2012
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Ingår i: European journal of endocrinology / European Federation of Endocrine Societies. - 1479-683X .- 0804-4643. ; 167:3, s. 353-62
-
Tidskriftsartikel (refereegranskat)abstract
- bjective: GH deficiency (GHD) in adults is associated with an altered serum lipid profile that responds to GH replacement therapy (GHRT). This study evaluated the influence of polymorphisms in genes related to lipid metabolism on serum lipid profile before and after 1 year of GHRT in adults. Design and methods: In 318 GHD patients, total cholesterol (TC) serum concentrations, LDL-C, HDL-C, and triglycerides (TG) were assessed. Using a candidate gene approach, 20 single nucleotide polymorphisms (SNPs) were genotyped. GH dose was individually titrated to obtain normal serum IGF1 concentrations. Results: At baseline, the minor alleles of cholesteryl ester transfer protein (CETP) gene SNPs rs708272 and rs1800775 were associated with higher serum TC and apolipoprotein E (APOE) gene SNP rs7412 with lower TC concentrations; CETP SNPs rs708272, rs1800775, and rs3764261 and apolipoprotein B (APOB) gene SNP rs693 with higher serum HDL-C; APOE SNP rs7412, peroxisome proliferator-activated receptor gamma (PPARG) gene SNP rs10865710 with lower LDL-C, and CETP SNP rs1800775 with higher LDL-C; and APOE/C1/C4/C2 cluster SNP rs35136575 with lower serum TG. After treatment, APOB SNP rs676210 GG genotype was associated with larger reductions in TC and LDL-C and PPARG SNP rs10865710 CC genotype with greater TC reduction. All associations remained significant when adjusted for age, sex, and BMI. Conclusions: In GHD adults, multiple SNPs in genes related to lipid metabolism contributed to individual differences in baseline serum lipid profile. The GH treatment response in TC and LDL-C was influenced by polymorphisms in the APOB and PPARG genes.
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| 42. |
- Baumann, C., et al.
(författare)
-
Search for direct photons in p+Pb and p+C collisions at sqrt(snn) = 17.4 GeV
- 2008
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Ingår i: Journal of Physics G: Nuclear and Particle Physics. - : IOP Publishing. - 0954-3899 .- 1361-6471. ; 35
-
Tidskriftsartikel (refereegranskat)abstract
- Upper limits on direct photon production were determined as a function of the transverse momentum for 0.7 < pT ≤ 3.2 GeV/c with the WA98 experiment in p + C and p + Pb collisions at . The results are compared to direct photon measurements in Pb + Pb collisions at by WA98. Implications for a possible thermal direct photon contribution are discussed.
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| 43. |
- Beckman, Linda, Docent, 1980-, et al.
(författare)
-
Relationship between Eczema and Self-reported Difficulties Keeping up with School Education : A Cross-sectional Study
- 2023
-
Ingår i: Acta Dermato-Venereologica. - : Medical Journals Sweden. - 0001-5555 .- 1651-2057. ; 103
-
Tidskriftsartikel (refereegranskat)abstract
- Eczema is a common chronic disease that affects both children and adults, and may have an adverse impact on school performance, as it is characteristically pruri-tic, and hence may lead to poor concentration and ina-dequate sleep. The aim of this study was to elucidate the relationship between eczema and self-reported difficulties keeping up with school education. The study was based on cross-sectional questionnaire data collec-ted in schools among all 9th graders (15–16 years old) within a Swedish county. Logistic regression analyses were used to assess the association between having eczema and self-reported difficulties keeping up with school education. A total of 2,620 pupils participated (50.1% female). An increased odds ratio (OR) of self-reported difficulties keeping up with school education was found in adolescents with eczema compared with those without eczema after adjustment for sex and family residence (OR 2.13, 95% confidence interval (95% CI) 1.32–3.44), and with additional adjustment for sleeping problems, attention-deficit hyperactivity disorder, allergy, rhinitis, asthma, and alcohol con-sumption (adjusted OR 1.78, CI 1.05–3.00). Eczema may be a relevant risk factor for difficulty keeping up with school education in adolescents. However, studies that can assess temporality, based in different settings with objective reports of both eczema and self-reported difficulties at school, are needed to con-firm these findings.
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| 44. |
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| 45. |
- Berg, Mats, et al.
(författare)
-
A Novel Formulation of Mometasone Furoate in Psoriasis Patients: A Multicenter, Randomized, Double-Blind Clinical Study
- 2013
-
Ingår i: Advances in Therapy. - : Springer Science and Business Media LLC. - 0741-238X .- 1865-8652. ; 30:5, s. 503-516
-
Tidskriftsartikel (refereegranskat)abstract
- Further formulations of mometasone furoate are needed for treatment of patients with plaque psoriasis to meet individual patient preferences. This has motivated the development of Ovixan(A (R)) (Galencia, Malmoe, Sweden), a formulation of mometasone furoate with different cosmetic properties than the commonly used formulation, Elocon(A (R)) (Merck [Schering Plough], Whitehouse Station, New Jersey, USA). This novel formulation of mometasone furoate was examined in a vasoconstrictor assay comparing its efficacy with that of Elocon. Subsequently, the new formulation was tested in a multicenter, randomized, double-blind clinical study in patients with plaque psoriasis. Healthy volunteers were included in the vasoconstrictor study. The treatments were randomly assigned to test fields on the forearms. The test fields were gently cleaned after treatment for 6 h. Skin color was measured during the following 24 h and area under the time curve was calculated. The clinical efficacy and tolerance of Ovixan was as compared to that of Elocon and their vehicles in a double-blind study in patients with plaque psoriasis. Patients with four symmetrically placed lesions on the arms or the legs were treated for 6 weeks. Primary endpoint was the change from baseline of the Total Severity Sign score for each treated lesion. The cosmetic characteristics of the two test preparations were assessed by an independent cosmetological institute. Ovixan was shown to have skin blanching potency almost identical to the vasoconstrictor potency of Elocon. Clinical equivalence of Ovixan to Elocon was demonstrated in the clinical study of the efficacy in patients with plaque psoriasis. A professional testing team clearly documented the cosmetic superiority of Ovixan as compared to Elocon. The results of the investigations show that Ovixan is equipotent to the commonly used formulation Elocon. However, the cosmetic properties are in favor of Ovixan. The effect of the cosmetic differences on patient preferences and patient adherence to prescribed treatment has to be investigated in further studies.
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| 46. |
- Berg, Åke, et al.
(författare)
-
Butterflies in semi-natural pastures and power-line corridors - effects of flower richness, management, and structural vegetation characteristics
- 2013
-
Ingår i: Insect Conservation and Diversity. - : Wiley. - 1752-458X .- 1752-4598. ; 6, s. 639-657
-
Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to compare the butterfly assemblages in semi-natural pastures and power-line corridors and to analyse the effects of vegetation height, occurrence of trees and shrubs and different flowering vascular plant groups on butterfly diversity and abundance. Twelve of 26 analysed butterfly species were more abundant in power-line corridors than in semi-natural pastures. Only one species preferred semi-natural pastures. In semi-natural pastures butterflies were most common in segments with tall vegetation, whereas butterflies in power-line corridors were most common in segments with vegetation of short or intermediate height. Short vegetation was sparser in power-line corridors (mean cover 4%) than in semi-natural pastures (33%), whereas tall vegetation was more common in power-line corridors (59%) than in semi-natural pastures (35%). The amount of flowers was the factor that affected the abundance of most species. Twenty-one of the 26 species showed positive associations with numbers of flowers of different families. Flowers of the plant families Apiaceae, Caryophyllaceae, Primulaceae, Rubiaceae, Scrophulariaceae, and Violaceae showed positive associations with the abundance of several butterfly species. Vegetation height seems to be a limiting factor in semi-natural pastures, and less intensive management (division of pastures into grazing pens, late season grazing, grazing every second year, or reduced grazing pressure) would benefit butterflies. In power-line corridors (dominated by tall vegetation) the opposite would be beneficial for butterflies, for example more frequent clearing of vegetation along the power-line trails combined with mowing of selected areas.
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| 47. |
- Berg, Åke, et al.
(författare)
-
Butterfly distribution and abundance is affected by variation in the Swedish forest-farmland landscape
- 2011
-
Ingår i: Biological Conservation. - : Elsevier BV. - 0006-3207 .- 1873-2917. ; 144, s. 2819-2831
-
Tidskriftsartikel (refereegranskat)abstract
- Remaining patches of semi-natural grasslands are hot spots for biodiversity in modern agricultural landscapes. In Sweden semi-natural pastures cover approximately 500,000 ha. However, power-line corridors, road verges and clear-cuts cover larger areas (in total about 2,000,000 ha), and these open, less intensively managed habitats are potentially important for species associated with taller vegetation and flower resources (e.g. pollinating insects). The aim of the present study was to evaluate the relative importance of semi-natural pastures and the other three open habitats for butterflies in 12 forest-farmland mosaic landscapes in south central Sweden. Species composition differed significantly between habitats in multivariate analyses. Power-line corridors and semi-natural pastures harbored several species that were disproportionally abundant in these habitats (13 and 8 species, respectively), and power-line corridors also harbored several species that were classified as typical in indicator species analyses. There were more butterfly species, higher abundances and a tendency for more individuals of red-listed species in power-line corridors than in the other three habitats. Effects of the surrounding landscape composition seemed to be weaker than that of the local habitat. However, species composition was significantly associated with landscape composition and species with intermediate and low mobility were more abundant in forested landscapes than in landscapes dominated by arable fields. Analyses of flying time and host plants for larvae suggest that early flying species and species associated with dwarf shrubs were more common in power-line corridors than in the other habitats. A landscape perspective, which takes several habitats into account, is needed for conservation of butterfly communities in forest-farmland landscapes. Power-line corridors and road verges offer possibilities for creating habitats that are suitable for pollinating insects through conservation-oriented management. (C) 2011 Elsevier Ltd. All rights reserved.
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| 48. |
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| 49. |
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| 50. |
- Berge, Maria, 1979-, et al.
(författare)
-
Constructions of power and knowledge in the technology classroom
- 2014
-
Konferensbidrag (refereegranskat)abstract
- The aim of this study is to investigate how knowledge and power are constituted in meaning-making processes in technology classrooms in relation to the teachers’ enactment of a disciplinary discourse. By collecting video data from a Swedish technology classroom in grade 8 we explore interaction on a micro-level. Our examination of the teaching of technology is motivated by the fact that this is a key period for students engagement in technology and that many students are losing interest in the subject during grades 7-9. Our analysis is guided by an analytical framework based on practical epistemology, teachers’ epistemological moves and the theory of didactical contract as completely implicit but highly powerful aspect of the relationship between teacher and student. Our analysis reveals that in the interaction between a teacher and her pupils both knowledge and power are mutually constituted in meaning-making processes, and are not possible to separate. It is therefore fruitful to use an analytical framework that includes both meaning-making and power in further research.
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