| 1. |
- Svensson, Bo S, et al.
(författare)
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Efter historien?
- 1985
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Ingår i: Res Publica. - 0282-6062. ; 1/1, s. 3-22
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 2. |
- Svensson, Bo S, et al.
(författare)
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Efterord: Perspektiv på fascismen
- 1984
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Ingår i: Terror och förhoppningar. Vardag under nazismen och i dagens Västtyskland.. - 9178680069 ; 2, s. 805-885
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Bokkapitel (populärvet., debatt m.m.)
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| 3. |
- Svensson, Bo S, et al.
(författare)
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Likgiltigheten är farligast. Om nynazism i dag.
- 1984
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Ingår i: Terror och förhoppningar. Vardag under nazismen och i dagens Västtyskland. - 9178680069 ; 2, s. 781-801
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Bokkapitel (populärvet., debatt m.m.)
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| 4. |
- Ammenberg, Jonas, et al.
(författare)
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Biogas Research Center, BRC : Slutrapport för etapp 1
- 2015
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Biogas Research Center (BRC) är ett kompetenscentrum för biogasforskning som finansieras av Energimyndigheten, LiU och ett flertal externa organisationer med en tredjedel vardera. BRC har en mycket bred tvärvetenskaplig inriktning och sammanför biogasrelaterad kompetens från flera olika områden för att skapa interaktion på flera olika plan:mellan näringsliv, akademi och samhälle,mellan olika perspektiv, samtmellan olika discipliner och kompetensområden.BRC:s vision är:Resurseffektiva biogaslösningar finns genomförda i många nya tillämpningar och bidrar till en mer hållbar energiförsörjning, förbättrat miljötillstånd och goda affärer.BRC:s särskilda roll för att uppnå denna vision är att bidra med kunskapsförsörjning och process-/teknikutveckling för att facilitera utveckling, innovation och implementering av biogaslösningar. Resurseffektivitet är ett nyckelord, vilket handlar om att förbättra befintliga processer och system samt utveckla biogaslösningar i nya sektorer och möjliggöra användning av nya substrat.For BRC:s etapp 1, den första tvåårsperioden mellan 2012-2014, var forskningsprojekten organiserade enligt tabellen nedan. Den visar viktiga utmaningar för biogasproducenter och andra intressenter, samt hur dessa ”angreps” med åtta forskningsprojekt. Fem av projekten var av explorativ karaktär i bemärkelsen att de var bredare och mer framtidsorienterade - exempelvis utvärderade flera möjliga tekniska utvecklingsmöjligheter (EP1-5). Tre projekt hade ett tydligare fokus på teknik- och processutveckling (DP6-8).I den här slutrapporten ges en kortfattad bakgrundsbeskrivning och det finns en introduktion till vad den här typen av kompetenscentrum innebär generellt. Därefter finns mer detaljerad information om BRC, exempelvis gäller det centrumets etablering, relevans, vision, hörnstenar och utveckling. De deltagande organisationerna presenteras, både forskargrupperna vid Linköpings universitet och partners och medlemmar. Vidare finns en mer utförlig introduktion till och beskrivning av utmaningarna i tabellen och kortfattat information om forskningsprojekten, följt av ett kapitel som berör måluppfyllelse och den externa utvärdering som gjorts av BRC:s verksamhet. Detaljerad, listad information finns till stor del i bilagorna.Kortfattat kan det konstateras att måluppfyllelsen överlag är god. Det är speciellt positivt att så många vetenskapliga artiklar publicerats (eller är på gång att publiceras) kopplat till forskningsprojekten och även i det vidare centrumperspektivet. Helt klart förekommer en omfattande verksamhet inom och kopplat till BRC. I etapp 2 är det viktigt att öka andelen mycket nöjda partner och medlemmar, där nu hälften är nöjda och hälften mycket nöjda. Det handlar framför allt om stärkt kommunikation, interaktion och projektledning. Under 2015 förväntas åtminstone två doktorsexamina, där avhandlingarna har stor koppling till forskningen inom etapp 1.I början på år 2014 skedde en extern utvärdering av verksamheten vid BRC med huvudsyftet att bedöma hur väl centrumet lyckats med etableringen samt att granska om det fanns förutsättningar för framtida framgångsrik verksamhet. Generellt var utfallet mycket positivt och utvärderarna konstaterade att BRC på kort tid lyckats etablera en verksamhet som fungerar väl och engagerar det stora flertalet deltagande aktörer, inom relevanta områden och där de flesta involverade ser BRC som en befogad och väl fungerande satsning, som de har för avsikt att även fortsättningsvis stödja. Utvärderingen bidrog också med flera relevant tips och till att belysa utmaningar.Utöver denna slutrapport finns separata publikationer från forskningsprojekten.Arbetet som presenteras i rapporten har finansierats av Energimyndigheten och de medverkande organisationerna.
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| 5. |
- Björn, Annika, 1972-
(författare)
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Microbial Transformation of Organotin Compounds under Simulated Landfill Conditions
- 2007
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Mono- and di-alkyltins are used extensively as heat stabilizers for processing of poly vinyl chloride (PVC). Tin mercaptide stabilizers are some of the most effective PVC stabilizers available. The main applications for tin stabilizers are building/construction products, such as pipes, fittings, siding and profiles (windows etc.), packaging and flexible PVC plastics. Most PVC products have been and are subjected to landfilling, when their use is terminated. The structure of the polymer itself and the substances used as additives have been a concern for environmental authorities in many countries since long, which also includes their presence in landfills. In the case of the organotin stabilizers their leaching out from (PVC) plastics into the leachate phase of landfills with the risk for further transport to ground and surface waters is in focus.The main objectives of this thesis take their start in this background and, thus, included the elucidation of whether organotin compounds (OTs) in stabilized PVC products contribute to the pool of OTs observed in landfill leachates and if these compounds are degradable by the microorganisms developing under anaerobic landfill conditions.To reach these aims and the research questions raised the forwarded PVC materials were added to muniscipal solid waste (MSW) processed in containers used to simulate the ageing of landfills under forced conditions. These include traditional landfill simulation reactors (LSRs) at a scale of ca 100 L and also at a smaller scale ca 5 L constructed for the purpose of this study, i.e. the modular environmental test system (METS). The latter were used to investigate temperature effects on the possible release of OTs from different types of PVC materials. The capacity by microorganisms in landfill environments were used to investigate their capacity to degrade or transform organotin stabilizer compounds focused on in this thesis. Differences in this capacity in relation to the ageing of landfills and exposure to the alkyltin stabilizers were studied with microorganisms sampled from LSRs spiked with PVC over time and from landfill site.Access to sensitive and reliable equipment and analytical protocols for the analysis of OTs and their transformation intermediates and end products are prerequisites for this kind of studies. This necessitated an adoption and adaptation of analytical methods for the low concentrations occurring in the environment. Two methods were established and well served the requirements.Indeed OTs migrated out from especially flexible PVC materials, while rigid PVC was less prone for OT release as judged from the METS simulations. The METS studies showed that the OT release increase substantially at higher temperatures and especially so when the temperature was higher than the glass transition of the PVC.materials.The organotin stabilizers were transformed, partly or completely degraded, by anaerobic microorganisms derived from landfill environments. Upon prolonged exposure to OTs leaching from PVC in LSR simulations the microorganisms displayed a higher efficiency in degradation of the leached OTs. The microorganisms would methylate inorganic tin and metyltin present in the MSW material as well as perform dealkylation depending on the tin concentrations prevailing. During these studies it was discovered that the organotin stabilzers were inhibiting the methanogens and fermentative bacteria, which lead to a retardation of the anaerobic mineralisation of the MSW in the assays. An in depth study revealed that the OTs themselves but also their ligands and degradation products from these together effected the inhibition.However, given the extent of leaching in relation to the water flows in landfills, the concentrations will mainly be too low to pose any risks to the surrounding environment.
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| 6. |
- Bodén, Bo, et al.
(författare)
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Kunskapsdriven turismutveckling i Västernorrland : Rapport från en förstudie
- 2006
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Den här rapporten redovisar en förstudie som Turismforskningsinstitutet ETOUR utfört på uppdrag av Länsstyrelsen i Västernorrland. Förstudien syftar till att utreda den regionala turismorganisationen i Västernorrlands län, samt analysera tre på förhand utpekade destinationer; Sundsvall med Timrå, Höga Kusten samt en inlandsdestination. I rapporten pekas även på möjliga vägar för fortsatt kunskapsdriven turismutveckling i Västernorrland. Ser vi till de utpekade destinationerna är det idag Sundsvall som förefaller mest kommersiellt driven med flera relativt tunga kommersiella aktörer inblandade i strategiarbetet. Viss otydlighet finns kring destinationens avgränsning, med Timrå och kustområdena som något perifera i den mobilisering som skett kring konferens- och shoppingturism. Vad gäller destinationsorganisation förefaller ett av privat logik dominerat destinationsbolag ligga närmast till hands. På Höga Kusten är bilden något mer sammansatt men grunden för en organisation driven med privat logik finns genom Entré Höga Kusten. Avgränsningen är något otydligt i fråga om hur mycket inland destinationen omfattar och hur det förhåller sig med Härnösands kommun, vid sidan av de dominerande kommunerna Örnsköldsvik och Kramfors. Höga Kusten världsarvsområde ligger helt inom dessa kommuner. Här finns också statligt engagemang genom Naturvårdsverket och Länsstyrelsen i Västernorrlands län. Om det är privat mobilisering kring turism som åsyftas förefaller dock Entré Höga Kusten med sina 110 medlemmar vara den naturliga organisatoriska basen. I Inlandet, som i denna studie främst behandlar Sollefteå kommun, är organiseringen svag. Ett fåtal privata aktörer mobiliserar krafterna och efterlyser samtidigt ett tydliggörande av kommunens hållning i turismfrågorna. Destinationens avgränsningar är otydliga då kopplingarna till andra delar än Sollefteå kommun är oklara och länkarna till aktörer utanför Ångermanälvens dalgång är svaga. Det är önskvärt med ett tydliggörande av destinationens geografi samt vilka aktörer som räknas och inte. I rapportens sista kapitel finns en diskussion om fortsatt kunskapsuppbyggnad knutet till turismutvecklingsarbetet i Västernorrlands län och dess destinationer. Det är uppenbart att de olika destinationerna skiljer sig åt och då mycket väl kan göra det avseende kunskapsbehov, medan de i andra avseenden kan förmodas ha liknande behov. Detta avsnitt kan ses som en första reflektion utifrån det nu genomförda pilotprojektet. Fortsatt dialog i dessa frågor följer för att kunna konkretiseras i ett eventuellt fortsatt samarbete under hösten 2006.
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| 7. |
- Börjesson, Gunnar, et al.
(författare)
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A national landfill methane budget for Sweden based on field measurements, and an evaluation of IPCC models
- 2009
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Ingår i: Tellus, Series B: Chemical and Physical Meteorology. - : Stockholm University Press. - 1600-0889 .- 0280-6509. ; 61:2, s. 424-435
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Tidskriftsartikel (refereegranskat)abstract
- Seven Swedish landfills were investigated from 2001 to 2003. On each landfill, a measure of the total methane production was calculated from data on: (1) methane emissions (leakage); (2) methane oxidation and (3) from gas recovery. Methane emissions were determined via a tracer gas (N2O) release-based remote sensing method. N2O and CH4 were measured with an Fourier Transform infrared detector at a distance of more than 1 km downwind from the landfills. Methane oxidation in the landfill covers was measured with the stable carbon isotope method. The efficiency in gas recovery systems proved to be highly variable, but on an average, 51% of the produced landfill gas was captured. A first-order decay model, based on four fractions (waste from households and parks, sludges and industrial waste), showed that the use of a degradable organic carbon fraction (DOCf) value of 0.54, in accordance with the default value for DOCf of 0.50 in the latest IPCC model, gave an emission estimate similar to the official national reports.
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| 8. |
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| 9. |
- Gad, Helge, et al.
(författare)
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MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool
- 2014
-
Ingår i: Nature. - : Nature Publishing Group. - 0028-0836 .- 1476-4687. ; 508:7495, s. 215-221
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Tidskriftsartikel (refereegranskat)abstract
- Cancers have dysfunctional redox regulation resulting in reactive oxygen species production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes oxidized dNTP pools to prevent incorporation of damaged bases during DNA replication. Although MTH1 is non-essential in normal cells, we show that cancer cells require MTH1 activity to avoid incorporation of oxidized dNTPs, resulting in DNA damage and cell death. We validate MTH1 as an anticancer target in vivo and describe small molecules TH287 and TH588 as first-in-class nudix hydrolase family inhibitors that potently and selectively engage and inhibit the MTH1 protein in cells. Protein co-crystal structures demonstrate that the inhibitors bindin the active site of MTH1. The inhibitors cause incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts. This study exemplifies the non-oncogene addiction concept for anticancer treatment and validates MTH1 as being cancer phenotypic lethal.
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| 10. |
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| 11. |
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| 12. |
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| 13. |
- Lindahl, Mattias, 1971-, et al.
(författare)
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Industrial cleaning with Qlean Water : a case study of printed circuit boards
- 2013
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Ingår i: Journal of Cleaner Production. - : Elsevier BV. - 0959-6526 .- 1879-1786. ; 47, s. 19-25
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Tidskriftsartikel (refereegranskat)abstract
- Many manufacturing companies are looking for ways to substitute environmentally problematic cleaning methods for surface treatments with more environmentally friendly ones. In this paper, one potential solution is described. The Qlean method, based on cleaning with highly pure water (in this paper defined as Qlean Water), is a novel cleaning method. This method, now utilized at one plant at a leading major international electronic company, has substituted previous chemical-based methods for cleaning printed circuit boards prior to lacquering. This paper presents, based on that company's primary data, a comparative study using environmental analysis and economic life cycle cost review between cleaning with Qlean Water and conventional cleaning. The focus is on the environmental and economic performance of the two alternatives. The conclusion is that Qlean Water offers both a significant economic and environmental cost reduction and a better product. This is the case even though all identified economic benefits derived from using Qlean Water, e.g. that the quality and technical lifetime have been extended for the printed circuit boards with the Qlean Water cleaning method, are not considered in the economic analysis.
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| 14. |
- McCamish-Svensson, C, et al.
(författare)
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Informal and formal support from a multi-disciplinary perspective: a Swedish follow-up between 80 and 82 years of age
- 1999
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Ingår i: Health & Social Care in the Community. - 0966-0410. ; 7:3, s. 163-163
-
Tidskriftsartikel (refereegranskat)abstract
- This longitudinal study used a multi-disciplinary approach and examined the relationship between psychosocial and health characteristics and the pattern of informal and formal support for non-institutionalized very old people. The data were derived from a single cohort of 80-year-old people living in Lund, Sweden who were followed over a 3-year period. In order to account for potential sample bias, an analysis at 80 years measured the differences between the participants who were measured at both test periods, the drop-outs who discontinued from the study prior to 82 years, and the deceased who died prior to 82 years (n = 212). Results revealed that the groups differed significantly according to reported number of children and health measures: the participants were most likely to have children and exhibited the best health. Bivariate analyses examined social, psychological and health variables for survivors (n = 93) at both 80 and 82 years in relationship to independent, informal, and formal support type. Loneliness was significantly and consistently associated with support type at both 80 and 82 years: both frequency and strength of loneliness were most often reported in the formal support group. Depression was significantly related to support type at age 80 only. Looking at change in the psychosocial and health measures and change in support over the 3-year period, no significant relationships were found. Our study concludes that for the very old, in addition to requiring increased support over a 3-year period, loneliness is a significant characteristic that may accompany the receipt of support. Professionals who plan and implement social support programmes for elderly persons should also consider emotional and psychological needs.
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| 15. |
- McCamish-Svensson, C, et al.
(författare)
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Social relationships and health as predictors of life satisfaction in advanced old age: results from a Swedish longitudinal study
- 1999
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Ingår i: International Journal of Aging and Human Development. - 0091-4150. ; 48:4, s. 301-324
-
Tidskriftsartikel (refereegranskat)abstract
- This longitudinal study examines the relationship between family and friend social support, health, and life satisfaction for a single cohort of eighty-year-old persons living in Lund, Sweden. Results indicate that participants who remained in the study are healthier and score higher on life satisfaction when compared with those who either drop-out or die prior to age eighty-three. Even though well-integrated with family and friends, the number of friends decreases significantly from eighty to eighty-three years; those who reported no close friends nearly doubled from eighty to eighty-three years. However, for those with close friends, contact with friends increases with age. In contrast to previous research, a correlational analysis indicates that neither child nor friend support is related to life satisfaction at either eighty or eighty-three years. However, health measures and satisfaction with sibling contact are related to total life satisfaction at age eighty-three only. These findings indicate the multidimensionality of both social support and life satisfaction for the old-old.
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| 16. |
- Rasmussen, Sune Olander, et al.
(författare)
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Ice-core data used for the construction of the Greenland Ice-Core Chronology 2005 and 2021 (GICC05 and GICC21)
- 2023
-
Ingår i: Earth System Science Data. - 1866-3508 .- 1866-3516. ; 15:8, s. 3351-3364
-
Tidskriftsartikel (refereegranskat)abstract
- We here describe, document, and make available a wide range of data sets used for annual-layer identification in ice cores from DYE-3, GRIP, NGRIP, NEEM, and EGRIP. The data stem from detailed measurements performed both on the main deep cores and shallow cores over more than 40 years using many different setups developed by research groups in several countries and comprise both discrete measurements from cut ice samples and continuous-flow analysis data.The data series were used for counting annual layers 60 000 years back in time during the construction of the Greenland Ice-Core Chronology 2005 (GICC05) and/or the revised GICC21, which currently only reaches 3800 years back. Now that the underlying data are made available (listed in Table 1) we also release the individual annual-layer positions of the GICC05 timescale which are based on these data sets.We hope that the release of the data sets will stimulate further studies of the past climate taking advantage of these highly resolved data series covering a large part of the interior of the Greenland ice sheet.
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| 17. |
- Saxena, Richa, et al.
(författare)
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Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
- 2007
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 316:5829, s. 1331-1336
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Tidskriftsartikel (refereegranskat)abstract
- New strategies for prevention and treatment of type 2 diabetes (T2D) require improved insight into disease etiology. We analyzed 386,731 common single-nucleotide polymorphisms (SNPs) in 1464 patients with T2D and 1467 matched controls, each characterized for measures of glucose metabolism, lipids, obesity, and blood pressure. With collaborators (FUSION and WTCCC/UKT2D), we identified and confirmed three loci associated with T2D - in a noncoding region near CDKN2A and CDKN2B, in an intron of IGF2BP2, and an intron of CDKAL1 - and replicated associations near HHEX and in SLC30A8 found by a recent whole-genome association study. We identified and confirmed association of a SNP in an intron of glucokinase regulatory protein (GCKR) with serum triglycerides. The discovery of associated variants in unsuspected genes and outside coding regions illustrates the ability of genome-wide association studies to provide potentially important clues to the pathogenesis of common diseases.
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| 18. |
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| 19. |
- Svensson, Bo, 1946-, et al.
(författare)
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Methane emission from Swedish mires : National and regional budgets and dependence on mire vegetation
- 2001
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Ingår i: Journal of Geophysical Research. - 0148-0227 .- 2156-2202. ; 106:D18, s. 20847-20860
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Tidskriftsartikel (refereegranskat)abstract
- A national land use inventory program was used to estimate the flux of methane from Swedish mires. During the snow-free season in 1994, methane fluxes were monitored at 60% (n = 619) of the total number of permanent inventory plots for the four mire vegetation classes included. The methane flux was measured only once at each inventory plot using transparent static chambers, yielding 3157 (89%) accepted flux rates. The temperature during the measurement period was close to the long-term (30 year) average in the north and much warmer in the south. The precipitation was lower than the long-term average. Average flux rates, specific for each mire vegetation class and geographical region, varied between 8 and 238 mg CH4 m-2 d-1. The national averages ▒ SE (mg CH4 m-2 d-1) were hummock communities, 24 ▒ 6, transitional fens, 15 ▒ 2, short sedge fens, 49 ▒ 4, and tall sedge fens, 97 ▒ 22. To derive the annual flux, the number of days with a daily average air temperature over 5░C was used. The annual methane fluxes for each mire vegetation class and region varied between 1.5 and 40 g CH4 m-2 yr-1. The annual methane fluxes (average ▒ SE in g m-2 yr-1) for each mire vegetation class for the whole of Sweden were hummock sites, 4.9 ▒ 1.3, transitional fens, 2.5 ▒ 0.5, low sedge fens, 8.2 ▒ 0.8, and tall sedge fens, 16.5 ▒ 3.6. The methane flux (▒95% confidence limits) in 1994 from the monitored mire types in Sweden was 0.29 ▒ 0.05 Tg CH4. The low and tall sedge mires accounted for 96% of the methane emitted. Copyright 2001 by the American Geophysical Union.
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| 20. |
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| 21. |
- Ahlstrand, Erik, et al.
(författare)
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Glycopeptide resistance in coagulase-negative staphylococci isolated in blood cultures from patients with hematological malignancies during three decades
- 2011
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Ingår i: European Journal of Clinical Microbiology and Infectious Diseases. - : Springer Science and Business Media LLC. - 0934-9723 .- 1435-4373. ; 30:11, s. 1349-1354
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to determine if there was a long-term increase in glycopeptide minimum inhibitory concentration (MIC) values, MIC creep, among bloodstream isolates of Staphylococcus epidermidis and S. haemolyticus isolated from patients with hematological malignancies. We conducted a retrospective single-center study where all positive blood cultures of S. epidermidis (n = 387) and S. haemolyticus (n = 19) isolated from patients with hematological malignancies during three decades, 1980 to 2009, were re-evaluated for the presence of reduced susceptibility to vancomycin and teicoplanin. Three different methods for the detection of reduced susceptibility to glycopeptides were used; standard Etest, macromethod Etest, and glycopeptide resistance detection (GRD) Etest. The median MIC value for vancomycin was 2 mg/L. MIC values for vancomycin and teicoplanin did not show any statistically significant increase during the study period. The presence of heterogeneously glycopeptide-intermediate staphylococci (hGIS) was analyzed among 405 coagulase-negative staphylococci (CoNS) isolates. hGIS were found in 31-45% of the CoNS isolates by the macromethod Etest and in 53-67% by the GRD Etest during the three decades. In conclusion, we did not observe any long-term glycopeptide MIC creep determined by the standard Etest, although a high and increasing proportion of heterogeneous vancomycin resistance was observed.
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| 22. |
- Ahlstrand, Erik, et al.
(författare)
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Long-term molecular epidemiology of Staphylococcus epidermidis blood culture isolates from patients with haematological malignancies
-
Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Staphylococcus epidermidis is an important cause of bloodstream infections in patients with haematological malignancies. Knowledge of the long-term epidemiology of these infections is limited. We surveyed all S. epidermidis blood culture isolates from patients treated for haematological malignancies at the University Hospital of Örebro, Sweden from 1980 to 2009. A total of 373 S. epidermidis isolates were identified and multilocus sequence typing and standard antibiotic susceptibility testing were employed to characterize these isolates. The majority of the isolates 361/373 (97%) belonged to clonal complex 2, and the 373 isolates were divided into 45 sequence types (STs); Simpson’s Diversity Index was 0.56. The most prevalent STs were ST2 (243/373, 65%) and ST215 (28/373, 8%). These two STs were isolated during the entire study period, and together caused temporal peaks in the incidence of positive blood cultures of S. epidermidis. Methicillin resistance was detected in 213/273 (78%) of all isolates. In the two predominating STs, ST2 and ST215, the proportion of methicillin resistance was 257/271 (95%); 234/271 (86%) displayed a multidrug-resistant phenotype. In conclusion, in this long-term study of patients with haematological malignancies, we demonstrate a predominance of methicillin-resistant ST2 among S. epidermidis blood culture isolates.
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| 23. |
- Ahlstrand, Erik, 1974-, et al.
(författare)
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Long-term molecular epidemiology of staphylococcus epidermidis blood culture isolates from patients with hematological malignancies
- 2014
-
Ingår i: PLOS ONE. - San Francisco, USA : Public Library Science. - 1932-6203. ; 9:6
-
Tidskriftsartikel (refereegranskat)abstract
- Staphylococcus epidermidis is an important cause of bloodstream infections in patients with hematological malignancies. Knowledge of the long-term epidemiology of these infections is limited. We surveyed all S. epidermidis blood culture isolates from patients treated for hematological malignancies at the University Hospital of Orebro, Sweden from 1980 to 2009. A total of 373 S. epidermidis isolates were identified and multilocus sequence typing, staphylococcal chromosome cassette mec (SCCmec) typing and standard antibiotic susceptibility testing were employed to characterize these isolates. The majority of the isolates 361/373 (97%) belonged to clonal complex 2, and the 373 isolates were divided into 45 sequence types (STs); Simpson's Diversity Index was 0.56. The most prevalent STs were ST2 (243/373, 65%) and ST215 (28/373, 8%). Ninety three percent (226/243) of the ST2 isolates displayed either SCCmec type III or IV. ST2 and 215 were isolated during the entire study period, and together these STs caused temporal peaks in the number of positive blood cultures of S. epidermidis. Methicillin resistance was detected in 213/273 (78%) of all isolates. In the two predominating STs, ST2 and ST215, methicillin resistance was detected in 256/271 isolates (95%), compared with 34/100 (34%) in other STs (p<0.001). In conclusion, in this long-term study of patients with hematological malignancies, we demonstrate a predominance of methicillin-resistant ST2 among S. epidermidis blood culture isolates.
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| 24. |
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| 25. |
- Ahrné, Karin, et al.
(författare)
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Dagfjärilar i naturbetesmarker, kraftledningsgator, på hyggen och skogsbilvägar : betydelse för miljöövervakning
- 2011
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Ett förändrat och intensifierat jordbruk har bland annat lett till att naturbetesmarker och andra gräsmarksbiotoper minskat i odlingslandskapet. Detta har fått till följd att många arter knutna till öppna gräsmarker minskat, däribland fåglar, växter och dagfjärilar. Dagfjärilar svarar snabbt på förändringar både i miljön och klimatet och kan därför vara viktiga indikatorarter för miljöövervakning. I år startar en nationell övervakning av dagfjärilar med hjälp av volontärer och de senaste fem åren har dagfjärilar inventerats i ängs- och betesmarker inom den nationella inventeringen av landskapet (NILS). För att få en rättvisande bild av hur situationen ser ut för dagfjärilar i Sverige kan det vara viktigt att systematiskt inventera olika typer av miljöer, inte enbart ängs- och betesmarker eller känt artrika platser. I den här studien jämför vi artrikedom, individantal och artsammansättning av dagfjärilar (Rophalocera) och bastardsvärmare (Zyganidaea) i naturbetesmarker och tre typer av öppna biotoper i skogslandskapet; hyggen, kraftledningsgator och skogsbilvägar. Vi delar också in fjärilarna efter val av värdväxt och flygtid på säsongen för att se om det finns några skillnader mellan biotoperna vad gäller art- och individrikedom inom dessa grupper. Vi undersöker hur mängden skog och betesmark inom det omgivande landskapet påverkar dagfjärilsfaunan på de olika platserna och hur många inventeringstillfällen (3, 5 eller 7) som krävs för att få tillförlitliga data på artrikedomen på en plats. Våra resultat visar att artsammansättningen av fjärilar skiljer sig mellan biotoperna och att alla bidrar med unika arter och således kompletterar varandra. Kraftledningsgatorhade både fler fjärilsarter och individer än de övriga biotoperna och hyggen och skogsbilvägar var lika art- och individrika som betesmarkerna. Det är därför viktigt att övervaka flera typer av miljöer och även skogsbiotoper inom framtida dagfjärilsövervakning. Eftersom alla tre skogsbiotoperna hyser en stor mångfald av fjärilar kan det vara värt att anpassa skötseln av dessa miljöer för att gynna fjärilar. I kraftledningsgator och skogsbilvägar som är relativt beständiga miljöer och som redan idag sköts med ett visst intervall är detta fullt möjligt. Betydelsen av antal inventeringstillfällen beror på vilken frågeställning man har. Vill man jämföra artrikedomen i olika miljöer eller studera förändring i artrikedom mellan år kan det kanske räcka med tre besök, men vill man ha en mer heltäckande bild av artrikedomen på en plats kan det sju eller fler besök spridda över säsongen
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| 26. |
- Aifa, Sami, et al.
(författare)
-
Interactions between the juxtamembrane domain of the EGFR and calmodulin measured by surface plasmon resonance
- 2002
-
Ingår i: Cellular Signalling. - 0898-6568 .- 1873-3913. ; 14:12, s. 1005-1013
-
Tidskriftsartikel (refereegranskat)abstract
- One early response to epidermal growth factor receptor (EGFR) activation is an increase in intracellular calcium. We have used surface plasmon resonance (SPR) to study real-time interactions between the intracellular juxtamembrane (JM) region of EGFR and calmodulin. The EGFR-JM (Met644-Phe688) was expressed as a GST fusion protein and immobilised on a sensor chip surface. Calmodulin specifically interacts with EGFR-JM in a calcium-dependent manner with a high on and high off rate. Chemical modification of EGFR-JM by using arginine-selective phenylglyoxal or deletion of the basic segment Arg645-Arg657 inhibits the interaction. Phosphorylation of EGFR-JM by protein kinase C (PKC) or glutamate substitution of Thr654 inhibits the interaction, suggesting that PKC phosphorylation electrostatically interferes with calmodulin binding to basic arginine residues. Calmodulin binding was also inhibited by suramin. Our results suggest that EGFR-JM is essential for epidermal growth factor (EGF)-mediated calcium-calmodulin signalling and for signal integration between other signalling pathways.
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| 27. |
- Ali, Neserin, et al.
(författare)
-
Analysis of nanoparticle-protein coronas formed in vitro between nanosized welding particles and nasal lavage proteins.
- 2016
-
Ingår i: Nanotoxicology. - : Taylor & Francis. - 1743-5390 .- 1743-5404. ; 10:2, s. 226-234
-
Tidskriftsartikel (refereegranskat)abstract
- Welding fumes include agglomerated particles built up of primary nanoparticles. Particles inhaled through the nose will to some extent be deposited in the protein-rich nasal mucosa, and a protein corona will be formed around the particles. The aim was to identify the protein corona formed between nasal lavage proteins and four types of particles with different parameters. Two of the particles were formed and collected during welding and two were manufactured iron oxides. When nasal lavage proteins were added to the particles, differences were observed in the sizes of the aggregates that were formed. Measurements showed that the amount of protein bound to particles correlated with the relative size increase of the aggregates, suggesting that the surface area was associated with the binding capacity. However, differences in aggregate sizes were detected when nasal proteins were added to UFWF and Fe2O3 particles (having similar agglomerated size) suggesting that yet parameters other than size determine the binding. Relative quantitative mass spectrometric and gel-based analyses showed differences in the protein content of the coronas. High-affinity proteins were further assessed for network interactions. Additional experiments showed that the inhibitory function of secretory leukocyte peptidase inhibitor, a highly abundant nasal protein, was influenced by particle binding suggesting that an understanding of protein function following particle binding is necessary to properly evaluate pathophysiological events. Our results underscore the importance of including particles collected from real working environments when studying the toxic effects of particles because these effects might be mediated by the protein corona.
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| 28. |
- Alirani, Gertrud, 1976-
(författare)
-
Miljöintegrering i praktisk tillämpning : En policystudie av två lokala stadsutvecklingsprocesser
- 2020
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Dealing with environmental problems has become one of the most challenging political issues of our time. Since the Brundtland report in 1987, environmental policy integration (EPI) that is, the mainstreaming of environmental issues in all policy sectors has emerged as a viable policy solution. This has meant that responsibility for implementing environmental policy rests to a large extent on local authorities where environmental problems with both local and global consequences are expected to be handled. However, there is still a disagreement on what EPI means in day-to-day decision making. With a theoretical framework drawing from theory on policy change, policy entrepreneurship and the neoinstitutional “logic of appropriateness” the aim of this dissertation is to analyze how the integration of environmental considerations manifests itself in local policy processes, highlighting what factors foster or hinder EPI. To reach this aim, I have followed two urban development processes in Kristianstad. This research offers insights on how EPI varies through the policy process and how focus is placed mainly on certain environmental issues and chiefly defined as of local importance. My study suggest that arenas for coordination are critical to overcoming the perceived “gap” between EPI on a strategic level and its implementation. This can help to clarify responsibility allocation among bureaucrats and their leeway for interpretation when new issues comes up continuously during the processes and affect the conditions for EPI. Furthermore, the dissertation gives insights on how acting “entrepreneurially” can enable an environmental issue to be included and given priority. This can also be a barrier if the ones acting entrepreneurially are not part of the entire process because the issue might receive less attention. In addition, if too much attention is given to one issue it might overshadow other environmental issues. Conversely, acting according to “the logic of appropriateness” can enable EPI by enhancing a more all-encompassing perspective on environmental considerations and also function as a cautious approach to radical change by preventing measures taken in absence of democratic legitimacy. By using the two theoretical perspectives, “entrepreneurial” and “appropriate” agency, this dissertation offers important insights into how different ways of acting interact and affect EPI and its outcome.
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| 29. |
- Andersson, Fräs Annika, 1974-
(författare)
-
Determination of Volatile Sulfur Compounds in Air and other Gas Matrices : Development and Applications of Solid-Phase Microextraction
- 2003
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Volatile sulphur compounds (VSCs) are frequently emitted during bioindustrial activities, such as production of biogas, sewage treatment, landfilling, pulpmilling, and the slaughtering of animals and meat processing. VSCs are reactive and malodorous, and they can also be detrimental to human health, therefore it is of great interest to be able to analyze these compounds.However, the standard techniques that are now available for determination of VSCs entail detection limits that in some cases exceed the odor thresholds, and, what is more, they require the use of solvents and toxic reagents. In addition, a single standard method does not exist that can be used to analyze all the VSCs that are most often associated with bioindustrial processes.In the present studies, a technique based on solid-phase microextraction (SPME) was developed for analysis of the VSCs that are commonly found in the bioindustry. The method could even be applied to very complex gas matrices representing point-source emissions of these compounds in amounts below their odor thresholds. Furthermore, the procedure constitutes an improvement compared to the other techniques employed to determine VSCs, because SPME is less time-consuming, it does not require the use of solvents or other chemicals, and it can extract all the compounds simultaneously. The potential of applying SPME for time-weighted average sampling of VSCs was also investigated. These experiments showed that the connnercially available fiber coating with the highest affmity for VSCs (i.e., Carboxen-polydimethylsiloxane)could achieve accurate determination of dimethyldisulfide, whereas use of thatcoating to collect the other compounds was highly influenced by externalparameters that are subject to variation. This work also included investigationsof several important aspects of SPME analysis of VSCs, such as the choice offiber coating, artifact formation, and the impact of various parameters on theextraction.The current results demonstrate that the SPME methodology that was developed can be used to determine VSCs in different matrices and contexts within the bioindustry. More precisely, the technique was successfully employed for the following purposes: to determine background levels ofVSCs to which workers were exposed; to monitor VSC emissions during the biogas process; to supervise the quality of produced biogas; to investigate the efficiency of processes used for abatement of VSCs; and to ascertain the cause of odor problems.
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| 30. |
- Andersson, Fräs Annika, et al.
(författare)
-
Occurrence and abatement of volatile sulfur compounds during biogas production
- 2004
-
Ingår i: Journal of the Air & Waste Management Association. - 1047-3289. ; 54:7, s. 855-861
-
Tidskriftsartikel (refereegranskat)abstract
- Volatile sulfur compounds (VSCs) in biogas originating from a biogas production plant and from a municipal sewage water treatment plant were identified. Samples were taken at various stages of the biogas-producing process, including upgrading the gas to vehicle-fuel quality. Solid-phase microextraction was used for preconcentration of the VSCs, which were subsequently analyzed using gas chromatography in combination with mass spectrometry. Other volatile organic compounds present also were identified. The most commonly occurring VSCs in the biogas were hydrogen sulfide, carbonyl sulfide, methanethiol, dimethyl sulfide, and dimethyl disulfide, and hydrogen sulfide was not always the most abundant sulfur (S) compound. Besides VSCs, oxygenated organic compounds were commonly present (e.g., ketones, alcohols, and esters). The effect of adding iron chloride to the biogas reactor on the occurrence of VSCs also was investigated. It was found that additions of 500-g/m3 substrate gave an optimal removal of VSCs. Also, the use of a prefermentation step could reduce the amount of VSCs formed in the biogas process. Moreover, in the carbon dioxide scrubber used for upgrading the gas, VSCs were removed efficiently, leaving traces (ppbv levels). The scrubber also removed other organic compounds.
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| 31. |
- Andersson, My, et al.
(författare)
-
Optogenetic control of human neurons in organotypic brain cultures
- 2016
-
Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 6
-
Tidskriftsartikel (refereegranskat)abstract
- Optogenetics is one of the most powerful tools in neuroscience, allowing for selective control of specific neuronal populations in the brain of experimental animals, including mammals. We report, for the first time, the application of optogenetic tools to human brain tissue providing a proof-of-concept for the use of optogenetics in neuromodulation of human cortical and hippocampal neurons as a possible tool to explore network mechanisms and develop future therapeutic strategies.
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| 32. |
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| 33. |
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| 34. |
- Anduaga, Walter, et al.
(författare)
-
Partial purification and characterization of acylester hydrolase from Lupinus mutabilis
- 1999
-
Ingår i: JAOCS, Journal of the American Oil Chemists' Society. - : Wiley. - 0003-021X. ; 76:10, s. 1157-1162
-
Tidskriftsartikel (refereegranskat)abstract
- An alkaline acylester hydrolase was partially purified from germinated seeds of Lupinus mutabilis. Hydrolytic activity was absent in the crude extract of ungerminated lupine seed, but it increased and peaked at the fourth day in the germinating seedling. The purification scheme involved homogenization, centrifugation, acetone precipitation, anion exchange chromatography, pH precipitation, and hydrophobic interaction chromatography. The acylester hydrolase was purified 126-fold, and the overall activity yield was 10%. The molecular weight estimated by sodium dodecylsulfate-polyacrylamide gel electrophoresis was 60 kDa. The enzyme had an isoelectric point of 6.2 and showed maximal activity at pH 8.0. The enzyme showed good stability between pH 5.0 and 9.0. In the pH range 7.0-7.5, enzyme precipitation was observed. The enzyme was stable from 0 to 25°C for 5 h and at 45°C lost 50% of its activity in the same period of time. At higher temperatures, the enzyme showed low thermal stability. However, the highest initial activity was found to be at 45°C. Nonionic surfactants and cholic acid enhanced the activity of the enzyme. The activity was reduced by the addition of toluene and isooctane and increased by the addition of diethyl ether, acetonitrile, methanol, and pyridine. The activity was reduced by 37% in the presence of 1 mM Cu2+ ions. The enzyme-hydrolyzed triolein showing no positional specificity.
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| 35. |
- Babatunde Adeleke, Solomon, et al.
(författare)
-
Geochemical control processes and potential sediment toxicity in a mine-impacted lake
- 2016
-
Ingår i: Environmental Toxicology and Chemistry. - : WILEY-BLACKWELL. - 0730-7268 .- 1552-8618. ; 35:3, s. 563-572
-
Tidskriftsartikel (refereegranskat)abstract
- Geochemical parameters and major ion concentrations from sediments of a freshwater lake in the town of angstrom tvidaberg, southeastern, Sweden, were used to identify the geochemical processes that control the water chemistry. The lake sediments are anoxic, characterized by reduced sulfur and sulfidic minerals. The hypothesis tested is that in sulfidic-anaerobic contaminated sediments, the presence of redox potential changes creates a favorable condition for sulfide oxidation, resulting in the release of potentially toxic metals. The acid volatile sulfide (AVS) contents ranged from 5.5mol/g to 16mol/g of dry sediment. Comparison of total mine tailing metals (Sigma mine tailing metals) with simultaneously extracted metals (SEM) in sediments indicates that up to 20% of the Sigma mine tailing metals are bound to the solid phase as AVS. Consequently, the AVS and SEM analysis classified all sediment samples as potentially toxic in terms of heavy metal concentrations (i.e., SEM to AVS ratio distribution>1). Evaluation of hydrogeochemical data suggests that calcite dissolution, iron (III) oxyhydroxysulfate mineral jarosite (H-jarosite) precipitation, hematite precipitation, and siderite precipitation are the most prevailing geochemical processes that control the geochemical interactions between the water column and sediment in a mine-impacted lake. The geochemical processes were verified and quantified using a chemical equilibrium modeling program, Visual MINTEQ, Ver 3.1, beta. The identified geochemical processes create an environment in which the characteristics of sulfate-rich waters and acidic-iron produce the geochemical conditions for acid mine drainage and mobilization of toxic metals. (c) 2015 SETAC
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| 36. |
- Bai, Bo, et al.
(författare)
-
Caching based socially-aware D2D communications in wireless content delivery networks: a hypergraph framework
- 2016
-
Ingår i: IEEE Wireless Communications. - 1536-1284 .- 1558-0687. ; 23:4, s. 74-81
-
Tidskriftsartikel (refereegranskat)abstract
- The emergence of the D2D communications paradigm has transformed the way in which cellular networks are operated. Previous work in D2D communications, however, mainly focused on interference management and capacity maximization of both D2D links and cellular links. Recent literature has observed that the QoE can be greatly enhanced by caching contents in mobile devices, with a carefully designed caching strategy. In this article, we propose a novel hypergraph framework that designs the caching based D2D communication scheme by taking social ties among users and common interests into consideration. We first present the considered features of the D2D transmission scheme, social characteristics consideration, and interest similarity impact. The key concepts of hypergraph and related techniques, such as hypergraph coloring and multidimensional matching, are explained. Then some design issues with simulation results in the proposed framework are discussed in detail, which show the potential of the proposed approach. By jointly considering social ties, common interests, and the D2D transmission scheme, we believe the proposed framework explores new opportunities and future directions in caching based socially-aware D2D communications.
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| 37. |
- Bartonek, Leo, et al.
(författare)
-
Bloch på svenska
- 1982
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Ingår i: TeKla. - 0348-7253. ; :12-13
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 38. |
- Bartonek, Leo, et al.
(författare)
-
Författarporträtt: Ernst Bloch
- 1978
-
Ingår i: Bokcaféets månadsbulletin. ; :27
-
Tidskriftsartikel (populärvet., debatt m.m.)
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| 39. |
- Bartonek, Leo, et al.
(författare)
-
Marxistisk öppenhet
- 1985
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Ingår i: Res Publica. - 0282-6062. ; nr 2 1985, s. 261-266
-
Recension (övrigt vetenskapligt/konstnärligt)
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| 40. |
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| 41. |
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| 42. |
- Benesch, Johan, et al.
(författare)
-
Protein adsorption to oligo(ethylene glycol) self-assembled monolayers : Experiments with fibrinogen, heparinized plasma, and serum
- 2001
-
Ingår i: Journal of Biomaterials Science. Polymer Edition. - : Taylor & Francis. - 0920-5063 .- 1568-5624. ; 12:6, s. 581-597
-
Tidskriftsartikel (refereegranskat)abstract
- Low protein adsorption is believed advantageous for blood-contacting materials and ethylene glycols (EG)-based polymeric compounds are often attached to surfaces for this purpose. In the present study, the adsorption of fibrinogen, serum, and plasma were studied by ellipsometry on a series of well-defined oligo(EG) terminated alkane-thiols self-assembled on gold. The layers were prepared with compounds of the general structure HS-(CH2)15-CONH-EGn, where n = 2, 4, and 6. Methoxy-terminated tri(EG) undecanethiol and hydroxyl-terminated hexadecanethiol self-assembled monolayers (SAMs) were used as references. The results clearly demonstrate that the adsorption depends on the experimental conditions with small amounts of fibrinogen adsorbing from a single protein solution, but larger amounts of proteins from serum and plasma. The adsorption of fibrinogen and blood plasma decreased with an increasing number of EG repeats and was temperature-dependent. Significantly less serum adsorbed to methoxy tri(EG) than to hexa(EG) and more proteins remained on the latter surface after incubation in a sodium dodecyl sulfate (SDS) solution, indicating a looser protein binding to the methoxy-terminated surface. All surfaces adsorbed complement factor 3(C3) from serum and plasma, although no surface-mediated complement activation was observed. The present study points to the importance of a careful choice of the protein model system before general statements regarding the protein repellant properties of potential surfaces can be made.
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| 43. |
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| 44. |
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| 45. |
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| 46. |
- Bennulf, Mattias, 1992-, et al.
(författare)
-
A conceptual model for multi-agent communication applied on a plug & produce system
- 2020
-
Ingår i: Procedia CIRP. - : Elsevier BV. - 2212-8271 .- 2212-8271. ; 93, s. 347-352
-
Tidskriftsartikel (refereegranskat)abstract
- Today, multi-agent systems are still uncommon in the industry because they require more time to be implemented than traditional manufacturing systems. In this paper, a conceptual model and guidelines are defined for communication and negotiation between agents for Plug & Produce systems. Standards for agent communication exists today, such as the FIPA collection of specifications. However, FIPA is a broad and general standard for any kind of system and leaves a lot of room for interpretation. This paper presents a new conceptual model and guidelines on how to simplify the implementation phase by limiting the choices an engineer must make when implementing a multi-agent system for a manufacturing system. © 2020 The Authors.
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| 47. |
- Bennulf, Mattias, 1992-
(författare)
-
A Control Framework for Industrial Plug & Produce
- 2023
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Kundanpassade produkter och korta produktionsserier blir alltmer populärt. Detta har lett till problem för dedikerade tillverkningssystem som är designade för massproduktion. Det krävs ofta långa produktionsserier för att det ska bli en rimlig investering att ställa om produktionen. Därför används människor för tillverkningsuppgifter som ofta ställs om. Denna avhandling fokuserar på konceptet Plug & Produce, som gör det enklare att flytta, lägga till och ta bort resurser från ett tillverkningssystem. Tanken är att resurser placeras i processmoduler som alla har samma fysiska gränssnitt för att kopplas in i tillverkningssystemet. Styrningen av tillverkningssystemet görs av ett multiagentsystem där varje detalj som ska produceras för produkter får en egen agent som representerar detaljen och agerar som styrningsmjukvara. Varje detaljs agent tar hand on sina egna tillverkningsmål genom att kommunicera med resursagenter i systemet som används för styrning av resurserna. I detta arbete, presenteras ett ramverk för Plug & Produce som består av ett konfigurerbart multiagentsystem, samt ett konfigurationsverktyg som kan användas för att definiera agenterna. Arbetet inkluderar metoder för att identifiera inkopplade resurser, kommunikation mellan agenter, schemaläggning som kan undvika konflikter mellan agenter, samt metoder för att automatiskt hitta vägar för transport genom tillverkningssystemet.
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| 48. |
- Bennulf, Mattias, 1992-, et al.
(författare)
-
A Method for Configuring Agents in Plug & Produce Systems
- 2022
-
Ingår i: SPS2022. - : IOS Press. - 9781643682686 - 9781643682693 ; , s. 135-146
-
Konferensbidrag (refereegranskat)abstract
- Multi-agent technology, used for implementing Plug & Produce systems have many proposed benefits for fast adaption of manufacturing systems. However, still today multi-agent technology is not ready for the industry, due to the lack of mature supporting tools and guidelines. The result is that today, multi-agent systems are more complicated and time-consuming to use than traditional approaches. This hides their true benefits. In this paper, a new method for configuring agents is presented that includes automated deployment to manufacturing systems and by its flexible design opens the possibility to connect many other supporting tools when needed. A configuration tool is also designed that works with the proposed method by connecting to an agent configuration database. The overall aim of the method is to simplify the steps taken for adapting a manufacturing system for new parts and resources.
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| 49. |
- Bennulf, Mattias, 1992-
(författare)
-
A User-Friendly Approach for Applying Multi-Agent Technology in Plug & Produce Systems
- 2020
-
Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis presents methods for simplifying the use of multi-agent systems in Plug & Produce. The demand for customized products and low volume production is constantly increasing. The industry has for many years used dedicated manufacturing systems where it is difficult and expensive to adapt to new product designs. Instead, factories are forced to use human workers for certain tasks that demand high flexibility and rapid adaption for new product designs. Several solutions have been proposed over the years to create highly flexible automation systems that automatically handles rapid adaption for new products. A concept called Plug & Produce aims at creating a system where resources and parts can be added in minutes rather than days in dedicated systems. One promising solution for implementing Plug & Produce is the distributed approach called multi-agent systems, where each resource and part get its own controller that communicates with each other to reach manufacturing goals. The idea is that the system automatically handles the adaption for new products. However, still today the use of such systems is extremely limited in the industry. One reason is the lack of mature multi-agent systems that are easy to use and that hides the complexity of the underlying agent system from the users. This is a huge problem since these systems tend to be more complex than traditional approaches. Thus, this thesis focuses on simplifying the use of multi-agent systems by proposing various methods for bringing the multi-agent technology for Plug & Produce closer to the industry.
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| 50. |
- Bennulf, Mattias, 1992-, et al.
(författare)
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Goal-Oriented Process Plans in a Multiagent System for Plug & Produce
- 2021
-
Ingår i: IEEE Transactions on Industrial Informatics. - : Institute of Electrical and Electronics Engineers (IEEE). - 1941-0050 .- 1551-3203. ; 17:4, s. 2411-2421
-
Tidskriftsartikel (refereegranskat)abstract
- This article presents a framework for Plug & Produce that makes it possible to use configurations rather than programming to adapt a manufacturing system for new resources and parts. This is solved by defining skills on resources, and goals for parts. To reach these goals, process plans are defined with a sequence of skills to be utilized without specifying specific resources. This makes it possible to separate the physical world from the process plans. When a process plan requires a skill, e.g., grip with a gripper resource, then that skill may require further skills, e.g., move with a robot resource. This creates a tree of connected resources that are not defined in the process plan. Physical and logical compatibility between resources in this tree is checked by comparing several parameters defined on the resources and the part. This article presents an algorithm together with a multiagent system framework that handles the search and matching required for selecting the correct resources.
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