| 1. |
- Bouyoucef, S E, et al.
(författare)
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Poster Session 2 : Monday 4 May 2015, 08
- 2015
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Ingår i: European Heart Journal Cardiovascular Imaging. - : Oxford University Press (OUP). - 2047-2404 .- 2047-2412. ; 16 Suppl 1
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Tidskriftsartikel (refereegranskat)
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| 2. |
- Lumbers, R. T., et al.
(författare)
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The genomics of heart failure: design and rationale of the HERMES consortium
- 2021
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Ingår i: Esc Heart Failure. - : Wiley. - 2055-5822. ; 8:6, s. 5531-5541
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Tidskriftsartikel (refereegranskat)abstract
- Aims The HERMES (HEart failure Molecular Epidemiology for Therapeutic targets) consortium aims to identify the genomic and molecular basis of heart failure. Methods and results The consortium currently includes 51 studies from 11 countries, including 68 157 heart failure cases and 949 888 controls, with data on heart failure events and prognosis. All studies collected biological samples and performed genome-wide genotyping of common genetic variants. The enrolment of subjects into participating studies ranged from 1948 to the present day, and the median follow-up following heart failure diagnosis ranged from 2 to 116 months. Forty-nine of 51 individual studies enrolled participants of both sexes; in these studies, participants with heart failure were predominantly male (34-90%). The mean age at diagnosis or ascertainment across all studies ranged from 54 to 84 years. Based on the aggregate sample, we estimated 80% power to genetic variant associations with risk of heart failure with an odds ratio of >1.10 for common variants (allele frequency > 0.05) and >1.20 for low-frequency variants (allele frequency 0.01-0.05) at P < 5 x 10(-8) under an additive genetic model. Conclusions HERMES is a global collaboration aiming to (i) identify the genetic determinants of heart failure; (ii) generate insights into the causal pathways leading to heart failure and enable genetic approaches to target prioritization; and (iii) develop genomic tools for disease stratification and risk prediction.
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| 3. |
- Shah, S, et al.
(författare)
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Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure
- 2020
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1, s. 163-
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Tidskriftsartikel (refereegranskat)abstract
- Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only limited insights, leaving the observed heritability of HF largely unexplained. We report results from a GWAS meta-analysis of HF comprising 47,309 cases and 930,014 controls. Twelve independent variants at 11 genomic loci are associated with HF, all of which demonstrate one or more associations with coronary artery disease (CAD), atrial fibrillation, or reduced left ventricular function, suggesting shared genetic aetiology. Functional analysis of non-CAD-associated loci implicate genes involved in cardiac development (MYOZ1, SYNPO2L), protein homoeostasis (BAG3), and cellular senescence (CDKN1A). Mendelian randomisation analysis supports causal roles for several HF risk factors, and demonstrates CAD-independent effects for atrial fibrillation, body mass index, and hypertension. These findings extend our knowledge of the pathways underlying HF and may inform new therapeutic strategies.
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| 4. |
- Estrada, Karol, et al.
(författare)
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Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
- 2012
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Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 44:5, s. 491-501
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Tidskriftsartikel (refereegranskat)abstract
- Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide association studies and 32,961 individuals of European and east Asian ancestry. We tested the top BMD-associated markers for replication in 50,933 independent subjects and for association with risk of low-trauma fracture in 31,016 individuals with a history of fracture (cases) and 102,444 controls. We identified 56 loci (32 new) associated with BMD at genome-wide significance (P < 5 × 10(-8)). Several of these factors cluster within the RANK-RANKL-OPG, mesenchymal stem cell differentiation, endochondral ossification and Wnt signaling pathways. However, we also discovered loci that were localized to genes not known to have a role in bone biology. Fourteen BMD-associated loci were also associated with fracture risk (P < 5 × 10(-4), Bonferroni corrected), of which six reached P < 5 × 10(-8), including at 18p11.21 (FAM210A), 7q21.3 (SLC25A13), 11q13.2 (LRP5), 4q22.1 (MEPE), 2p16.2 (SPTBN1) and 10q21.1 (DKK1). These findings shed light on the genetic architecture and pathophysiological mechanisms underlying BMD variation and fracture susceptibility.
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| 5. |
- Istomin, S. Ya., et al.
(författare)
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Tuning the high-temperature properties of Pr2NiO4+delta by simultaneous Pr- and Ni-cation replacement
- 2016
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Ingår i: RSC Advances. - : Royal Society of Chemistry (RSC). - 2046-2069. ; 6:40, s. 33951-33958
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Tidskriftsartikel (refereegranskat)abstract
- Novel Pr2-xSrxNi1-xCoxO4 +/-delta (x = 0.25; 0.5; 0.75) oxides with the tetragonal K2NiF4-type structure have been prepared. Room-temperature neutron powder diffraction (NPD) study of x = 0.25 and 0.75 phases together with iodometric titration results have shown the formation of hyperstoichiometric oxide for x = 0.25 (delta = 0.09(2)) and a stoichiometric one for x = 0.75. High-temperature X-ray powder diffraction (HT XRPD) showed substantial anisotropy of the thermal expansion coefficient (TEC) along the a-and c-axis of the crystal structure, which increases with increasing the Co content from TEC(c)/TEC(a) = 2.4 (x = 0.25) to 4.3 (x = 0.75). High-temperature NPD (HT NPD) study of the x = 0.75 sample reveals that a very high expansion of the axial (Ni/Co)-O bonds (75.7 ppm K-1 in comparison with 9.1 ppm K-1 for equatorial ones) is responsible for such behaviour, and is caused by a temperature-induced transition between low- and high-spin states of Co3+. This scenario has been confirmed by high-temperature magnetization measurements on a series of Pr2-xSrxNi1-xCoxO4 +/-delta samples. For compositions with high Ni content (x = 0.25 and 0.5) we synthesised K2NiF4-type oxides Pr2-x-ySrx+y(Ni1-xCox)O-4 +/-delta, y = 0.0-0.75 (x = 0.25); y = 0.0-0.5 (x = 0.5). The studies of the TEC, high-temperature electrical conductivity in air, chemical stability of the prepared compounds in oxygen and toward interaction with Ce2-xGdxO2-x/2 (GDC) at high temperatures reveal optimal behaviour of Pr1.35Sr0.65Ni0.75Co0.25O4+delta. This compound shows stability in oxygen at 900 degrees C and does not react with GDC at least up to 1200 degrees C. It features low TEC of 13 ppm K-1 and high-temperature electrical conductivity in air of 280 S cm(-1) at 900 degrees C, thus representing a promising composition for use as a cathode material in intermediate temperature solid oxide fuel cells (IT-SOFC).
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| 6. |
- Zubkov, V. G., et al.
(författare)
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Structural, vibrational, electronic, and luminescence properties of the cyclotetravanadates A(2)M(VO3)(4) (A=Na,Ag; M=Ca,Sr)
- 2008
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Ingår i: Physical Review B. Condensed Matter and Materials Physics. - 1098-0121 .- 1550-235X. ; 77, s. 174113-
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Tidskriftsartikel (refereegranskat)abstract
- The physical properties of the family of cyclotetravanadates A(2)M(VO3)(4), where A=Na,Ag and M=Ca,Sr, have been studied by means of x-ray powder diffraction, neutron diffraction, electron diffraction, infrared, Raman, NMR, photoexcitation and pulse cathode beam excitation, and x-ray photoelectron spectroscopies, and band structure calculations. The differences between the structural, vibrational, luminescence, and electronic properties of the alkali metal-containing [Na2Ca(VO3)(4) and Na2Sr(VO3)(4)] and the d metal-containing cyclotetravanadates [Ag2Ca(VO3)(4) and Ag2Sr(VO3)(4)] are analyzed. Na2Ca(VO3)(4), Ag2Ca(VO3)(4), Na2Sr(VO3)(4), and Ag2Sr(VO3)(4) have tetragonal structures, P4/nbm, with a=10.438 49(6), 10.445 24(5), 10.634 49(4), and 10.625 74(6), and c=4.938 73(5), 4.968 45(5), 4.962 05(4), and 4.979 30(4) angstrom, respectively. The main structural feature of A(2)M(VO3)(4) is the tetracyclic [V4O12] units. The hybridized O 2p-V 3d states of the tetracyclic [V4O12] units have a dominant influence on the electronic structure of these compounds. The compounds are semiconducting with a local density approximation band gap increasing, from 1.85 eV for Ag2Ca(VO3)(4) to 3.02 eV for Na2Ca(VO3)(4). The prospects of these compounds as advanced materials for detectors of photon and corpuscular radiation as well as for color correction of light emission sources such as lamp and light emitting diode sources are discussed.
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| 7. |
- Napolsky, Ph S., et al.
(författare)
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Structure and high-temperature properties of the (Sr,Ca,Y)(Co, Mn)O3-y perovskites - perspective cathode materials for IT-SOFC
- 2012
-
Ingår i: Journal of Solid State Chemistry. - : Elsevier BV. - 0022-4596 .- 1095-726X. ; 192, s. 186-194
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Tidskriftsartikel (refereegranskat)abstract
- Oxygen deficient perovskites Sr0.75Y0.25Co1-xMnxO3-y, x=0.5 and 0.75, were prepared by using the citrate route at 1373-1573 K for 48 h. The cubic Pm-3m perovskite structure for x=0.5 was confirmed by electron diffraction study and refined using neutron powder diffraction (NPD) data. For x=0.75, the superstructure corresponding to a=root 2 x a(per), b=2 x a(per), c=root 2 x a(per) (a(0)b(-)b(-) tilt system, space group Imma) was revealed by electron diffraction. The solid solution Sr0.75-xCaxY0.25Co0.25Mn0.75O3-y, 0.1 <= x <= 0.6 and compound Ca0.75Y0.25Mn0.85Co0.15O2.92 were prepared in air at 1573 K for 48 h. The crystal structure of Ca0.75Y0.25Mn0.85Co0.15O2.92 was refined using NPD data (S.G. Pnma, a=5.36595(4), b=7.5091(6), c=5.2992(4) angstrom, R-p=0.057, R-wp=0.056, chi(2)=4.26). High-temperature thermal expansion properties of the prepared compounds were studied in air using both dilatometry and high-temperature X-ray powder diffraction data (HTXRPD). They expanding non-linearly at 298-1073 K due to the loss of oxygen at high temperatures. Calculated average thermal expansion coefficients (TECs) for Sr0.75Y0.25Co1-xMnxO3-y, x=0.5, 0.75 and Ca0.75Y0.25Mn0.85Co0.15O2.92(1) are 15.5, 15.1, and 13.8 ppm K-1, respectively. Anisotropy of the thermal expansion along different unit cell axes was observed for Sr0.15Ca0.6Y0.25Co0.25Mn0.75O3-y, and Ca0.75Y0.25Mn0.85Co0.15O2.92. Conductivity of Sr0.75Y0.25Co1-xMnxO3-y, x=0.5 and 0.75 increases with the temperature reaching 110 S/cm for x=0.5 and 44 S/cm for x=0.75 at 1173 K. Samples of Sr0.75-xCaxY0.25Co0.25Mn0.75O3-y, 0.1 <= y <= 0.6 were found to be n-type conductors at room temperature with the similar temperature dependence of the conductivity and demonstrated the increase of the sigma value from similar to 1 to similar to 50 S/cm as the temperature increases from 300 to 1173 K. Their conductivity is described in terms of the small polaron charge transport with the activation energy (E-p) increasing from 340 to 430 meV with an increase of the calcium content from x=0 to x=0.6.
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| 8. |
- Cedervall, Jessica, et al.
(författare)
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Neutrophil extracellular traps promote cancer-associated inflammation and myocardial stress.
- 2022
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Ingår i: Oncoimmunology. - : Informa UK Limited. - 2162-4011 .- 2162-402X. ; 213, s. S2-S3
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Tidskriftsartikel (refereegranskat)abstract
- Cancer is associated with systemic pathologies that contribute to mortality, such as thrombosis and distant organ failure. The aim of this study was to investigate the potential role of neutrophil extracellular traps (NETs) in myocardial inflammation and tissue damage in treatment-naïve individuals with cancer. Mice with mammary carcinoma (MMTV-PyMT) had increased plasma levels of NETs measured as H3Cit-DNA complexes, paralleled with elevated coagulation, compared to healthy littermates. MMTV-PyMT mice displayed upregulation of pro-inflammatory markers in the heart, myocardial hypertrophy and elevated cardiac disease biomarkers in the blood, but not echocardiographic heart failure. Moreover, increased endothelial proliferation was observed in hearts from tumor-bearing mice. Removal of NETs by DNase I treatment suppressed the myocardial inflammation, expression of cardiac disease biomarkers and endothelial proliferation. Compared to a healthy control group, treatment-naïve cancer patients with different malignant disorders had increased NET formation, which correlated to plasma levels of the inflammatory marker CRP and the cardiac disease biomarkers NT-proBNP and sTNFR1, in agreement with the mouse data. Altogether, our data indicate that NETs contribute to inflammation and myocardial stress during malignancy. These findings suggest NETs as potential therapeutic targets to prevent cardiac inflammation and dysfunction in cancer patients.
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| 9. |
- Oei, Ling, et al.
(författare)
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A genome-wide copy number association study of osteoporotic fractures points to the 6p25.1 locus
- 2014
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Ingår i: Journal of Medical Genetics. - : BMJ Publishing Group. - 0022-2593 .- 1468-6244. ; 51:2, s. 122-131
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Osteoporosis is a systemic skeletal disease characterised by reduced bone mineral density and increased susceptibility to fracture; these traits are highly heritable. Both common and rare copy number variants (CNVs) potentially affect the function of genes and may influence disease risk.AIM: To identify CNVs associated with osteoporotic bone fracture risk.METHOD: We performed a genome-wide CNV association study in 5178 individuals from a prospective cohort in the Netherlands, including 809 osteoporotic fracture cases, and performed in silico lookups and de novo genotyping to replicate in several independent studies.RESULTS: A rare (population prevalence 0.14%, 95% CI 0.03% to 0.24%) 210 kb deletion located on chromosome 6p25.1 was associated with the risk of fracture (OR 32.58, 95% CI 3.95 to 1488.89; p=8.69×10(-5)). We performed an in silico meta-analysis in four studies with CNV microarray data and the association with fracture risk was replicated (OR 3.11, 95% CI 1.01 to 8.22; p=0.02). The prevalence of this deletion showed geographic diversity, being absent in additional samples from Australia, Canada, Poland, Iceland, Denmark, and Sweden, but present in the Netherlands (0.34%), Spain (0.33%), USA (0.23%), England (0.15%), Scotland (0.10%), and Ireland (0.06%), with insufficient evidence for association with fracture risk.CONCLUSIONS: These results suggest that deletions in the 6p25.1 locus may predispose to higher risk of fracture in a subset of populations of European origin; larger and geographically restricted studies will be needed to confirm this regional association. This is a first step towards the evaluation of the role of rare CNVs in osteoporosis.
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| 10. |
- Shafeie, Samrand, 1984-, et al.
(författare)
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Tracking of high-temperature thermal expansion and transport properties vs. oxidation state of cobalt between +2 and +3 in the La2Co1+z(Ti1-xMgx)(1-z)O-6-system
- 2012
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Ingår i: Journal of Materials Chemistry. - : Royal Society of Chemistry (RSC). - 0959-9428 .- 1364-5501. ; 22:32, s. 16269-16276
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Tidskriftsartikel (refereegranskat)abstract
- The high-temperature thermal expansion and electronic transport properties of the B-site substituted LaCoO3 with both variable oxidation state of cobalt between +2 and +3 (La2Co(Ti1-xMgx)O-6, 0 <= x <= 0.5) and variable Co3+-content relative to the other B-cations (La2Co1+z(Ti0.5Mg0.5)(1-z)O-6, 0.2 <= z <= 0.6) have been investigated. Based on the temperature dependence of the thermal expansion, electronic transport properties and Seebeck coefficient, three different groups of compositions according to their symmetries can be allocated. It was found that the thermal expansion coefficients (TECs) of the studied compounds are mainly dependent on the proportion of Co2+/Co3+. For La2Co(Ti1-xMgx)O-6, the TEC increases from similar to 9 (x = 0) to similar to 19 ppm K-1 (x = 0.5) with an increase of the oxidation state of cobalt from +2 to +3, respectively. The TECs of La2Co1+z(Ti0.5Mg0.5)(1-z)O-6, z = 0.2-0.6 with Co3+-only, remain constant at similar to 21 ppm K-1 independent of the cobalt content. Thermoelectric measurements of the system indicate that all samples in the system, except La2Co1.6(Ti0.5Mg0.5)(0.4)O-6, are p-type conductors over the whole temperature range, 300 < T < 1175 K. The conductivities were found to increase with an increase of both Co3+ and total cobalt content and are described with a small polaron hopping model. Due to an insignificant number of oxygen vacancies of La2Co1+z(Ti1-xMgx)(1-z)O-6 samples prepared in air at elevated temperatures, the investigated system is proposed as an excellent model system for the investigation of the influence of the Co oxidation state and stoichiometry on different properties in perovskite cobalt oxides.
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| 11. |
- Tyutyunnik, A P, et al.
(författare)
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Synthesis, superconducting properties and structural (including electron diffraction) studies of Na chi NbO2 and Li chi NbO2
- 1996
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Ingår i: European Journal of Solid State and Inorganic Chemistry. - : Wiley. - 0992-4361 .- 1873-3751. ; 33, s. 53-65
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Tidskriftsartikel (refereegranskat)abstract
- Monophasic NaxNbO2 (x = 0.5 - 0.6), T-c approximate to 4.1 K was prepared by solid state reaction between Na3NbO4 and Nb. X-ray powder diffraction data from a monophasic sample were used for a refinement of the structure of Na0.5NbO2 (R(p) = 7.4 % and R(I) = 5.3 %), using the Rietveld method. At low x-values a closely related second phase can occur. Rietveld refinement using X-ray powder diffraction data showed this phase to be isostructural with NaNbO2 but with the chemical formula Na0.1NbO2. Transmission electron microscopy studies of NaxNbO2 and LixNbO2 revealed the presence of superstructures in some crystallites. The electron diffraction patterns resemble to some extent those reported for transformations among tantalum chalcogenides.
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| 12. |
- Zubkov, V G, et al.
(författare)
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Condensed cluster phases in reduced oxoniobates: synthesis and studies of Sr4−xNb17O26 (x=0.0(1), 0.3(1)) and Eu4−xNb17O26 (x=0.3(1)) :
- 1997
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Ingår i: Journal of Alloys and Compounds. - 0925-8388 .- 1873-4669. ; 256, s. 129-139
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Tidskriftsartikel (refereegranskat)abstract
- Sr4−xNb17O26 (x=0.0, 0.3) and Eu4−xNb17O26 (x = 0.3) were synthesised from SrCO3/Eu2O3 and Nb2O5 in a vacuum furnace at temperatures up to 1600°C (1500°C for Eu) using acetylene soot or Nb as reducing agents. The synthetic studies show that these phases are only formed via an intermediate disordered ‘phase’ (or phasoid). Sr4−xNb17O26 and Eu4−xNb17O26 are isostructural with Ba4Nb17O26 and crystallise in space group P 4/m (83) with the unit cell parameters for and and , respectively. The crystal structure can be described as an intergrowth between ANbO3 and NbO. Characteristic building blocks are quadruple chains of corner-sharing Nb6-octahedra. ?The structures of Sr4−xNb17O26 and Eu4−xNb17O26 were refined using X-ray powder diffraction and neutron diffraction data (only Sr4−xNb17O26). The Rietveld refiniments and microanalyses showed x in Eu4−xNb17O26 to be 0.3(l) while the Sr analogue both x= 0.0(1) and 0.3(1) were found. High resolution electron microscopy studies showed that the compounds frequently contained structural defects. The magnetic susceptibility of Eu4−xNb17O26 (x=0.3) shows a Curie-Weiss behaviour, with a magnetic moment in good agreement with the expected μeff=7.9 μB for Eu2+/ The Sr analogie is temperature-independent paramagnetic at room temperature, Sr4−xNb17O26 (x=0.3) and Eu4−xNb17O26 (x=0.3) are metallic, with a resistivity increasing with temperature.
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| 13. |
- Chernov, S. V., et al.
(författare)
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Sr2GaScO5, Sr10Ga6Sc4O25, and SrGa0,75Sc0,25O2,5: a Play in the Octahedra to Tetrahedra Ratio in Oxygen-Deficient Perovskites
- 2012
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Ingår i: Inorganic Chemistry. - : American Chemical Society (ACS). - 0020-1669 .- 1520-510X. ; 51:2, s. 1094-1103
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Tidskriftsartikel (refereegranskat)abstract
- Three different perovskite-related phases were isolated in the SrGa(1-x)Sc(x)O(2.5) system: Sr(2)GaScO(5), Sr(10)Ga(6)Sc(4)O(25), and SrGa(0.75)Sc(0.25)O(2.5), Sr(2)GaScO(5) (x = 0.5) crystallizes in a brownrnillerite-type structure [space group (S.G.) Icmm, a = 5.91048(5) angstrom, b = 15.1594(1) angstrom, and c = 5.70926(4) angstrom] with complete ordering of Sc(3+) and Ga(3+) over octahedral and tetrahedral positions, respectively. The crystal structure of Sr(10)Ga(6)Sc(4)O(25) (x = 0.4) was determined by the Monte Carlo method and refined using a combination of X-ray, neutron, and electron diffraction data [S.G. I4(1)/a, a = 17.517(1) angstrom, c = 32.830(3) angstrom]. It represents a novel type of ordering of the B cations and oxygen vacancies in perovskites. The crystal structure of Sr(10)Ga(6)Sc(4)O(25) can be described as a stacking of eight perovskite layers along the c axis ...[-(Sc/Ga)O(1.6)-SrO(0.8)-(Sc/Ga)O(1.8)-SrO(0.8)-](2 center dot center dot center dot) Similar to Sr(2)GaScO(5), this structure features a complete ordering of the Sc(3+) and Ga(3+) cations over octahedral and tetrahedral positions, respectively, within each layer. A specific feature of the crystal structure of Sr(10)Ga(6)Sc(4)O(25) is that one-third of the tetrahedra have one vertex not connected with other Sc/Ga cations. Further partial replacement of Sc(3+) by Ga(3+) leads to the formation of the cubic perovskite phase SrGa(0.75)Sc(0.25)O(2.5) (x = 0.25) with a = 3.9817(4) angstrom. This compound incorporates water molecules in the structure forming SrGa(0.75)Sc(0.25)O(2.5)center dot xH(2)O hydrate, which exhibits a proton conductivity of similar to 2.0 x 10(-6) S/cm at 673 K.
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| 14. |
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| 15. |
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| 16. |
- Kaluzhskikh, M. S., et al.
(författare)
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High-temperature crystal structure and transport properties of the layered cuprates Ln(2)CuO(4), Ln=Pr, Nd and Sm
- 2011
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Ingår i: Journal of Solid State Chemistry. - : Elsevier BV. - 0022-4596 .- 1095-726X. ; 184:3, s. 698-704
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Tidskriftsartikel (refereegranskat)abstract
- High-temperature crystal structure of the layered cuprates Ln(2)CuO(4), Ln = Pr, Nd and Sm with tetragonal T'-structure was refined using X-ray powder diffraction data. Substantial anisotropy of the thermal expansion behavior was observed in their crystal structures with thermal expansion coefficients (TEC) along a- and c-axis changing from TEC(a)/TEC(c)approximate to 1.37 (Pr) to 0.89 (Nd) and 0.72 (Sm). Temperature dependence of the interatomic distances in Ln(2)CuO(4) shows significantly lower expansion rate of the chemical bond between Pr and oxygen atoms (O1) belonging to CuO(2)-planes (TEC(Pr-O1)= 11.7 ppm K(-1)) in comparison with other cuprates: TEC (Nd-O1)=15.2 ppm K(-1) and TEC (Sm-O1)= 15.1 ppm K(-1). High-temperature electrical conductivity of Pr(2)CuO(4) is the highest one in the whole studied temperature range (298-1173 K): 0.1-108 S/cm for Pr(2)CuO(4), 0.07-23 S/cm for Nd(2)CuO(4) and 2 X 10(-4)-9 S/cm for Sm(2)CuO(4). The trace diffusion coefficient (D(T)) of oxygen for Pr(2)CuO(4) determined by isotopic exchange depth profile (IEDP) technique using secondary ion mass spectrometry (SIMS) varies in the range 7.2 X 10(-13) Cm(2)/S (973 K) and 3.8 X 10(-10) Cm(2)/S (1173 K) which are in between those observed for the manganese and cobalt-based perovskites.
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| 17. |
- Peredkov, Sergey, et al.
(författare)
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Ioniclike energy structure of neutral core-excited states in free Kr clusters
- 2005
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Ingår i: Physical Review A (Atomic, Molecular and Optical Physics). - 1050-2947. ; 72:2
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Tidskriftsartikel (refereegranskat)abstract
- The development of electronic states in krypton clusters is investigated by high-resolution core-level electron spectroscopy. The energy ordering of bulk versus surface 3d(-1)np(n > 5) core-excited states in neutral clusters is demonstrated to be reversed to the 3d(-1)5p level situation. The cluster 3d(-1)6p,7p states are proven to be at a lower energy than the corresponding atomic levels. These findings reveal the ioniclike energy structure of the neutral cluster core-excited levels. The phenomenon is explained by a spatial spread of the excited orbitals over the cluster lattice.
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| 18. |
- Robroek, Bjorn J. M., et al.
(författare)
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Microclimatological consequences for plant and microbial composition in Sphagnum-dominated peatlands
- 2014
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Ingår i: Boreal environment research. - Helsinki, Finland : Finnish Environment Institute. - 1239-6095 .- 1797-2469. ; 19:3, s. 195-208
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Tidskriftsartikel (refereegranskat)abstract
- In three Scandinavian peatlands we studied to what extent plant and microbial community compositions are governed by local-scale microhabitat, with a special interest in the effect of aspect (i.e. exposition of slopes). Despite differences in solar irradiance between the south- and north-facing slopes, maximum temperature was elevated in the south-facing slopes at the most northern site only. Pore-water nutrient concentrations were not affected by aspect, yet dissolved organic carbon concentrations were higher in the south-facing microhabitats. This was likely caused by higher vascular plant biomass. Plant and microbial community composition clearly differed among sites. In all three sites, microhabitat (i.e. prevailing water-table depth) affected the plant and microbial community compositions. Aspect, however, did not affect community composition, even though microclimate significantly differed between the south- and the north-facing aspects at the northernmost site. Our results highlight the complex link between plant community composition, microbial community and environmental conditions, which deserves much more attention than currently in order to fully understand the effects of climate change on peatland ecosystem function.
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| 19. |
- Shafeie, Samrand, 1984-, et al.
(författare)
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Phase formation, crystal structures and magnetic properties of perovskite-type phases in the system La2Co1+z(MgxTi1-x)1-zO6
- 2011
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Ingår i: Journal of Solid State Chemistry. - : Elsevier BV. - 0022-4596 .- 1095-726X. ; 184:1, s. 177-190
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Tidskriftsartikel (refereegranskat)abstract
- Perovskite-type cobaltates in the system La(2)Co(1+z) (Mg(x)Ti(1-x))(1-z)O(6) were studied for z=0 <= x <= 0.6 and 0 <= x <= 0.9, using X-ray and neutron powder diffraction, electron diffraction (ED), magnetic susceptibility measurements and X-ray absorption near-edge structure (XANES) spectroscopy. The samples were synthesised using the citrate route in air at 1350 degrees C. The space group symmetry of the structure changes from P2(1)/n via Pbnm to R (3) over barc with both increasing Mg content and increasing Co content. The La(2)Co(Mg(x)Ti(1-x))O(6) (z=0) compounds show anti-ferromagnetic couplings of the magnetic moments for the Co below 15 K for x=0, 0.1 and 0.2. XANES spectra show for the compositions 0 <= x <= 0.5 a linear decrease in the L(3)/(L(3)+ L(2))Co-L(2.3) edge branching ratio with x, in agreement with a decrease of the average Co ion spin-state, from a high-spin to a lower-spin-state, with decreasing nominal Co(2+) ion content.
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| 20. |
- Tyutyunnik, A. P., et al.
(författare)
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CRYSTAL STRUCTURE AND VIBRATIONAL SPECTRA OF M[VO(2)(SeO(4))(H(2)O)(2)]center dot H(2)O (M = K, Rb, NH(4))
- 2011
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Ingår i: Journal of Structural Chemistry. - 0022-4766 .- 1573-8779. ; 52:2, s. 350-357
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Tidskriftsartikel (refereegranskat)abstract
- By the hydration of MVO(SeO(4))(2) with saturated water vapors at room temperature a series of isostructural complex compounds of vanadium(V) of the composition M[VO(2)(SeO(4))(H(2)O)(2)]center dot H(2)O (K, Rb, NH(4)) are synthesized and their physicochemical properties are studied. Based on the X-ray and neutron diffraction data, it is found that their crystal structure is composed of VO(6) octahedra linked in infinite chains by bridging SeO(4) tetrahedra. Each of the VO(6) octahedra has two short terminal V-O bonds forming a bent dioxovanadium group VO(2)(+). Two water molecules are coordinated by vanadium and one molecule is out of the first coordination sphere in the interchain space. The vibrational spectra of the studied compounds are completely consistent with their structural features.
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| 21. |
- Biendicho, Jordi Jacas, et al.
(författare)
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Synthesis and characterization of perovskite-type SrxY1−xFeO3−δ (0.63≤x<1.0) and Sr0.75Y0.25Fe1−yMyO3−δ (M=Cr, Mn, Ni), (y=0.2, 0.33, 0.5)
- 2013
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Ingår i: Journal of Solid State Chemistry. - : Elsevier BV. - 0022-4596 .- 1095-726X. ; 200, s. 30-38
-
Tidskriftsartikel (refereegranskat)abstract
- Oxygen-deficient ferrates with the cubic perovskite structure SrxY1-xFeO3-d were prepared in air (0.71 ≤ x ≤ 0.91) as well as in N2 (x=0.75 and 0.79) at 1573K. The oxygen content of the compounds prepared in air increases with increasing strontium content from 3-δ=2.79(2) for x=0.75 to 3-δ=2.83(2) for x=0.91. Refinement of the crystal structure of Sr0.75Y0.25FeO2.79 using TOF neutron powder diffraction (NPD) data shows high anisotropic atomic displacement parameter (ADP) for the oxygen atom resulting from a substantial cation and anion disorder. Electron diffraction (ED) and high-resolution electron microscopy (HREM) studies of Sr0.75Y0.25FeO2.79 reveal a modulation along <100>p with G± ~0.4<100>p indicating a local ordering of oxygen vacancies. Magnetic susceptibility measurements at 5-390K show spin-glass behaviour with dominating antiferromagnetic coupling between the magnetic moments of Fe cations. Among the studied compositions, Sr0.75Y0.25FeO2.79 shows the lowest thermal expansion coefficient (TEC) of 10.5 ppm K-1 in air at 298-673K. At 773-1173K TEC increases up to 17.2 ppm K-1 due to substantial reduction of oxygen content. The latter also results in a dramatic decrease of the electrical conductivity in air above 673K. Partial substitution of Fe by Cr, Mn and Ni according to the formula Sr0.75Y0.25Fe1-yMyO3-δ (y=0.2, 0.33, 0.5) leads to cubic perovskites for all substituents with y=0.2. Their TECs are higher in comparison with un-doped Sr0.75Y0.25FeO2.79. Only M=Ni has increased electrical conductivity compared to un-doped Sr0.75Y0.25FeO2.79.
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| 22. |
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| 23. |
- Chen, X., et al.
(författare)
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A genome-wide association study of IgM antibody against phosphorylcholine: shared genetics and phenotypic relationship to chronic lymphocytic leukemia
- 2018
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Ingår i: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 27:10, s. 1809-1818
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Tidskriftsartikel (refereegranskat)abstract
- Phosphorylcholine (PC) is an epitope on oxidized low-density lipoprotein (oxLDL), apoptotic cells and several pathogens like Streptococcus pneumoniae. Immunoglobulin M against PC (IgM anti-PC) has the ability to inhibit uptake of oxLDL by macrophages and increase clearance of apoptotic cells. From our genome-wide association studies (GWASs) in four European-ancestry cohorts, six single nucleotide polymorphisms (SNPs) in 11q24.1 were discovered (in 3002 individuals) and replicated (in 646 individuals) to be associated with serum level of IgM anti-PC (the leading SNP rs35923643-G, combined beta = 0.19, 95% confidence interval 0.13-0.24, P = 4.3 x 10-11). The haplotype tagged by rs35923643-G (or its proxy SNP rs735665-A) is also known as the top risk allele for chronic lymphocytic leukemia (CLL), and a main increasing allele for general IgM. By using summary GWAS results of IgM anti-PC and CLL in the polygenic risk score (PRS) analysis, PRS on the basis of IgM anti-PC risk alleles positively associated with CLL risk (explained 0.6% of CLL variance, P = 1.2 x 10-15). Functional prediction suggested that rs35923643-G might impede the binding of Runt-related transcription factor 3, a tumor suppressor playing a central role in the immune regulation of cancers. Contrary to the expectations from the shared genetics between IgM anti-PC and CLL, an inverse relationship at the phenotypic level was found in a nested case-control study (30 CLL cases with 90 age- and sex-matched controls), potentially reflecting reverse causation. The suggested function of the top variant as well as the phenotypic association between IgM anti-PC and CLL risk needs replication and motivates further studies.
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| 24. |
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| 25. |
- Esmaily, Mohsen, 1987, et al.
(författare)
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Microstructural characterization of the Mg-Al alloy AM50 produced by a newly developed rheo-casting process
- 2014
-
Ingår i: Materials Characterization. - : Elsevier BV. - 1044-5803 .- 1873-4189. ; 95, s. 50-64
-
Tidskriftsartikel (refereegranskat)abstract
- The microstructure of rheo-cast Mg-Al alloy AM50 produced by the RheoMetal process is investigated and compared with the same alloy produced by conventional high pressure die casting. The size and arrangement of microstructural constituents and pores are characterized quantitatively using image analyzing techniques. The nearest neighbor distribution of the intermetallic particles is determined. The area fraction of porosity in rheo-cast AM50 is about half that found in the high pressure die cast alloy. In rheo-cast material, the distribution of p phase (Mg17Al12) is relatively uniform throughout the cast. In contrast, the beta phase particles tend to form macroscopic agglomerates in high pressure die cast material. The externally solidified grains in the rheo-cast material exhibit a smaller aluminum gradient than in the high pressure die cast alloy. This indicates that the solidification of the rheo-cast material is closer to equilibrium.
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| 26. |
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| 27. |
- Felser, C, et al.
(författare)
-
Metal valence states in Eu0.7NbO3, EuNbO3, and Eu2Nb5O9 by TB-LMTO-ASA band-structure calculations and resonant photoemission spectroscopy
- 1998
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Ingår i: Physical Review B Condensed Matter. - 0163-1829 .- 1095-3795. ; 57, s. 1510-1514
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Tidskriftsartikel (refereegranskat)abstract
- The electronic structures of Eu2Nb5O9, EuNbO3, and Eu0.7NbO3 have been investigated by photoemission and total-yield spectroscopy with synchrotron radiation, and in the case of Eu2Nb5O9 by tight-binding linear muffin-tin orbital (LMTO) band-structure calculations. A central question for reduced europium niobates is that of the valence of Eu and Nb. Both europium and niobium atoms can appear in different valence states so that various electronic configurations in the title compounds are possible. For this reason, the valence band was studied by the resonant Eu 4d⃗4f technique to determine the Eu valence. The final-state 4f6 multiplet of divalent Eu is dominant in all spectra. Since there are no 4f density of states at the Fermi level, valence fluctuations are not expected. The niobium valence states were investigated by core-level spectroscopy. We found only one 3d5/23d3/2 doublet for the Nb 3d core level in EuNbO3 and Eu0.7NbO3, while in Eu2Nb5O9, two 3d doublets have been observed, corresponding to two chemically distinct niobium atoms in this compound. The 3d5/2 peak in EuNbO3 is assigned to the +4 nominal valence state at a binding energy of 209.7 eV. The doublet of Eu0.7NbO3 is observed at 0.5 eV higher binding energy (at 210.2 eV), which then corresponds to a nominal Nb+4+δ chemical state. In Eu2Nb5O9, the valence of Nb in the NbO6 octahedra is less than +5 and in the Nb6O12 clusters is close to +2 as expected. This is in accordance with the LMTO band-structure calculations
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| 28. |
- Fossum, M., et al.
(författare)
-
Autologous in vitro cultured urothelium in hypospadias repair{star, open}
- 2007
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Ingår i: Journal of Pediatric Urology. - : Elsevier BV. - 1477-5131 .- 1873-4898. ; 3:1, s. 10-18
-
Tidskriftsartikel (refereegranskat)abstract
- Objective: To treat severe hypospadias with a transplant of autologous in vitro cultured urothelial cells on acellular dermis. Patients and methods: During 2000-2002 six patients aged 14-44 months with severe hypospadias were treated surgically with autologous urothelial cell transplants. All were born with scrotal or perineal hypospadias and pronounced chordee. All patients were subjected to a two-staged procedure starting with repair of the chordee. Urothelial cell harvesting via bladder lavage was performed during the first operation. The neourethra was constructed by using a transplant with cultured urothelium in an on-lay fashion. Patients have been followed 3-5.5 years. Results: All six boys are voiding through their neourethra without straining and have no residual urine after micturition. Five patients are using a standing voiding position and present bell shaped, urinary flow curves. One developed a stricture treated conservatively with persisting good effect (after more than 5 years). Two developed a fistula requiring surgical correction that was uneventful. The last patient developed an obstruction in the proximal anastomosis that was treated with an internal urethrotomy. Cosmetic appearance is good in all cases with good parental satisfaction. Urethroscopy in all patients show a wide penile neourethra. Biopsies indicate a mucosal lining consisting of urothelial cells in three cases. Conclusion: This technique is feasible for treatment of a selected group of hypospadias where pronounced chordee and shortage of preputial and penile skin complicates the creation of a neourethra. It may have other clinical implications including disorders such as bladder exstrophy and cloacal malformations, as well as mutilating traumatic injuries or cancer therapy. © 2006 Journal of Pediatric Urology Company.
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| 29. |
- Gisselbrecht, Mathieu, et al.
(författare)
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Size dependent fragmentation of argon clusters in the soft x-ray ionization regime.
- 2008
-
Ingår i: Journal of Chemical Physics. - : AIP Publishing. - 0021-9606 .- 1089-7690. ; 128:4
-
Tidskriftsartikel (refereegranskat)abstract
- Photofragmentation of argon clusters of average size ranging from 10 up to 1000 atoms is studied using soft x-ray radiation below the 2p threshold and multicoincidence mass spectroscopy technique. For small clusters (N=10), ionization induces fast fragmentation with neutral emission imparting a large amount of energy. While the primary dissociation takes place on a picosecond time scale, the fragments undergo slow degradation in the spectrometer on a microsecond time scale. For larger clusters (N>/=100) we believe that we observe the fragmentation pattern of multiply charged species on a time-scale which lasts a few hundred nanoseconds. The reason for these slower processes is the large number of neutral atoms which act as an efficient cooling bath where the excess energy ("heat") dissipates among all degrees of freedom. Further degradation of the photoionic cluster in spectrometer then takes place on the microsecond time scale, similar to small clusters.
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| 30. |
- Israelsson, Niklas, 1983, et al.
(författare)
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A Microstructural and Kinetic Investigation of the KCl-Induced Corrosion of an FeCrAl Alloy at 600 A degrees C
- 2015
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Ingår i: Oxidation of Metals. - : Springer Science and Business Media LLC. - 1573-4889 .- 0030-770X. ; 84:1-2, s. 105-127
-
Tidskriftsartikel (refereegranskat)abstract
- The corrosion behaviour of a FeCrAl alloy was investigated at 600 A degrees C in O-2 + H2O with solid KCl applied. A kinetics and microstructural investigation showed that KCl accelerates corrosion and that potassium chromate formation depletes the protective scale in Cr, thus triggering the formation of a fast-growing iron-rich scale. Iron oxide was found to grow both inward and outward, on either side of the initial oxide. A chromia layer is formed with time underneath the iron oxide. It was found that although the alloy does not form a continuous pure alumina scale at the investigated temperature, aluminium is, however, always enriched at the oxide/alloy interface.
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| 31. |
- Israelsson, Niklas, 1983, et al.
(författare)
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Cyclic Corrosion and Chlorination of an FeCrAl Alloy in the Presence of KCl
- 2015
-
Ingår i: Oxidation of Metals. - : Springer Science and Business Media LLC. - 1573-4889 .- 0030-770X. ; 84:3-4, s. 269-290
-
Tidskriftsartikel (refereegranskat)abstract
- The KCl-induced corrosion of the FeCrAl alloy Kanthal® APMT in an O 2 + N 2 + H 2 O environment was studied at 600 °C. The samples were pre-oxidized prior to exposure in order to investigate the protective nature of alumina scales in the present environment. The microstructure and composition of the corroded surface was investigated in detail. Corrosion started at flaws in the pre-formed α-alumina scales, i.e. α-alumina was protective in itself. Consequently, KCl-induced corrosion started locally and, subsequently, spread laterally. An electrochemical mechanism is proposed here by which a transition metal chloride forms in the alloy and K 2 CrO 4 forms at the scale/gas interface. Scale de-cohesion is attributed to the formation of a sub-scale transition metal chloride.
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| 32. |
- Kaban, I., et al.
(författare)
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Atomic structure and formation of CuZrAl bulk metallic glasses and composites
- 2015
-
Ingår i: Acta Materialia. - : Elsevier BV. - 1359-6454 .- 1873-2453. ; 100, s. 369-376
-
Tidskriftsartikel (refereegranskat)abstract
- Cu47.5Zr47.5Al5 metallic glass is studied experimentally by high-energy X-ray diffraction, neutron diffraction with isotopic substitution, electron diffraction and X-ray absorption spectroscopy. The atomic structure of the glass is modeled by reverse Monte-Carlo and molecular dynamics simulations. RMC modeling of seven experimental datasets enabled reliable separation of all partial pair distribution functions for Cu47.5Zr47.5Al5 metallic glass. A peculiar structural feature of the ternary alloy is formation of the strong Al-Zr bonds, which are supposed to determine its high viscosity and enhanced bulk glass formation. Analysis of the local atomic order in Cu47.5Zr47.5Al5 glass and Cu10Zr7, CuZr2 and CuZr B2 crystalline structures elucidates their similarities and differences explaining the phase formation sequence by devitrification of the glass.
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| 33. |
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| 34. |
- Kravchenko, Ekaterina, et al.
(författare)
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High-Temperature Structural and Electrical Characterization of Reduced Oxygen-Deficient Ruddlesden-Popper Nickelates
- 2018
-
Ingår i: European Journal of Inorganic Chemistry. - : Wiley. - 1434-1948 .- 1099-1948 .- 1099-0682. ; :28, s. 3320-3329
-
Tidskriftsartikel (refereegranskat)abstract
- High-temperature characterization of oxygen-deficient Sr-rich (La1-xSrx)(2)NiO4-delta (x = 0.5-0.8) solid solutions under mildly reducing conditions with p(O-2) approximate to 5x10(-5) atm was performed by employing structural and thermal analysis, TEM, and electrical conductivity measurements. Oxygen losses from the crystal lattice on reduction were found to result in a reversible transition from the tetragonal (I4/mmm) to the orthorhombic (Immm) structure and shrinkage of the crystal lattice for the compositions with x > 0.5. TEM and thermogravimetric analysis evidenced slow kinetics of the structural transition. The increase in oxygen deficiency under reducing conditions is accompanied by localization of the electronic charge carriers, a drop of the p-type electronic conductivity, and a transition from metallic-like to semiconducting behavior. The extent of changes in oxygen nonstoichiometry, unit--cell dimensions, average Ni oxidation state, electron-hole concentration, and electronic conductivity on reduction is interrelated with the strontium content. The results suggest that the electrical conductivity of (La1-xSrx)(2)NiO4-delta ceramics depends mainly on the average Ni oxidation state.
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| 35. |
- Leis, J, et al.
(författare)
-
Carbon nanostructures produced by chlorinating aluminium carbide
- 2001
-
Ingår i: Carbon. - 0008-6223 .- 1873-3891. ; 39:13, s. 2043-2048
-
Tidskriftsartikel (refereegranskat)abstract
- A number of carbon samples with different nanostructures such as: amorphous, nanoparticles and turbostratic, were synthesised through the reaction between aluminium carbide and gaseous chlorine at fixed temperatures between 300 and 900 degreesC. The synthesised carbon samples were characterised using high-resolution transmission electron microscopy and X-ray powder diffraction techniques, as well as low temperature nitrogen sorption measurements. The carbon produced at T=300 degreesC was amorphous with a surface area of similar to 1400 m(2) g(-1). At 700 degreesC, a large amount of carbon nanoparticles and with a lower surface area similar to 710 m(2) g(-1) was obtained. At 900 degreesC, mainly a turbostratic carbon with a surface area of similar to 680 m(2) g(-1) was produced.
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| 36. |
- Leis, J, et al.
(författare)
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Catalytic effects of metals of the iron subgroup on the chlorination of titanium carbide to form nanostructural carbon
- 2002
-
Ingår i: Carbon. - 0008-6223 .- 1873-3891. ; 40:9, s. 1559-1564
-
Tidskriftsartikel (refereegranskat)abstract
- The effect of the reaction temperature and the metals of an iron subgroup on the thermo-chemical treatment of titanium carbide with a chlorine gas and their influence on the carbon structure obtained thereby was studied. Different analytical methods such as porosity measure me tits, X-ray diffraction spectrometry and a high-resolution electron microscopy revealed the catalytic behaviour of the above-mentioned metals. which appeared to support the formation of graphitised carbon at much lower temperatures compared to those needed for the ordinary thermo-chemical chlorination of titanium carbide.
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| 37. |
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| 38. |
- Lindblad, A, et al.
(författare)
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The geometric structure of pure SF6 and mixed Ar/SF6 clusters investigated by core level photoelectron spectroscopy
- 2009
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Ingår i: Surface Science. - : Elsevier BV. - 0039-6028 .- 1879-2758. ; 603:3, s. 433-436
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Tidskriftsartikel (refereegranskat)abstract
- The S 2p core level photoelectron spectra of Sulphurhexafluoride Clusters have been investigated together with heterogeneous Ar/SF6 clusters, created by doping Ar host clusters (with a mean size of 3600 atoms) with the molecule. Surface and bulk features are resolved both in the argon 2p and the sulphur 2p core level photoelectron spectra. For the latter level such features were only observed in the pure cluster case; a single feature characterizes the S 2p core level spectra of SF6 doped argon clusters. From the chemical shifts, investigated with respect to SF6 doping pressure. It can be concluded that the host clusters get smaller with increasing doping pressures and that the SF6 molecules predominantly stay below the cluster surface, whereas the Argon core stays intact. We have neither observed features corresponding to SF6 on the cluster Surface, nor features corresponding to molecules deep inside the bulk in any of the spectra from the pick-up experiments.
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| 39. |
- Linnarsson, M K, et al.
(författare)
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Metal-contact enhanced incorporation of deuterium in 4H-and 6H-SiC
- 2000
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Ingår i: Materials Science Forum. - 0255-5476 .- 1662-9752. ; 338-3, s. 937-940, s. 937-940
-
Tidskriftsartikel (refereegranskat)abstract
- Deuterium was introduced in p-type SiC from a gas ambient. The samples were partially coated with 200 Angstrom thick metal layer of titanium, nickel, platinum or gold. Heat treatments were performed in the temperature range 500-800 degreesC during 4 h. Secondary ion mass spectrometry (SIMS) was used to measure the deuterium content after deuterium exposure. The catalytic metal coating is shown to play an important role for introducing deuterium into SiC. Nickel and platinum facilitate hydrogen incorporation in p-type SiC, which may be due to an increased hydrogen concentration at the metal/SiC interface and/or an increase the H+ ions to H ratio. No in-diffusion of deuterium is observed using titanium although large quantities of deuterium are stored in the titanium film. Furthermore, gold reveals an inert character and does not promote in-diffusion of deuterium.
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| 40. |
- Lira-Junior, Ronaldo, et al.
(författare)
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S100A12 Expression Is Modulated During Monocyte Differentiation and Reflects Periodontitis Severity
- 2020
-
Ingår i: Frontiers in Immunology. - : Frontiers Media S.A.. - 1664-3224. ; 11
-
Tidskriftsartikel (refereegranskat)abstract
- S100A12 is a calcium-binding protein of the S100 subfamily of myeloid-related proteins that acts as an alarmin to induce a pro-inflammatory innate immune response. It has been linked to several chronic inflammatory diseases, however its role in the common oral immunopathology periodontitis is largely unknown. Previous in vitro monoculture experiments indicate that S100A12 production decreases during monocyte differentiation stages, while the regulation within tissue is poorly defined. This study evaluated S100A12 expression in monocyte subsets, during monocyte-to-macrophage differentiation and following polarization, both in monoculture and in a tissue context, utilizing a three-dimensional co-culture oral tissue model. Further, we explored the involvement of S100A12 in periodontitis by analyzing its expression in peripheral circulation and gingival tissue, as well as in saliva. We found that S100A12 expression was higher in classical than in non-classical monocytes. S100A12 expression and protein secretion declined significantly during monocyte-to-macrophage differentiation, while polarization of monocyte-derived macrophages had no effect on either. Peripheral monocytes from periodontitis patients had higher S100A12 expression than monocytes from controls, a difference particularly observed in the intermediate and non-classical monocyte subsets. Further, monocytes from periodontitis patients displayed an increased secretion of S100A12 compared with monocytes from controls. In oral tissue cultures, monocyte differentiation resulted in increased S100A12 secretion over time, which further increased after inflammatory stimuli. Likewise, S100A12 expression was higher in gingival tissue from periodontitis patients where monocyte-derived cells exhibited higher expression of S100A12 in comparison to non-periodontitis tissue. In line with our findings, patients with severe periodontitis had significantly higher levels of S100A12 in saliva compared to non-periodontitis patients, and the levels correlated to clinical periodontal parameters. Taken together, S100A12 is predominantly secreted by monocytes rather than by monocyte-derived cells. Moreover, S100A12 is increased in inflamed tissue cultures, potentially as a result of enhanced production by monocyte-derived cells. This study implicates the involvement of S100A12 in periodontitis pathogenesis, as evidenced by increased S100A12 expression in inflamed gingival tissue, which may be due to altered circulatory monocytes in periodontitis.
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| 41. |
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| 42. |
- Manderstedt, Eric, et al.
(författare)
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Classic Thrombophilias and Thrombotic Risk Among Middle-Aged and Older Adults : A Population-Based Cohort Study
- 2022
-
Ingår i: Journal of the American Heart Association. - : Wiley-Blackwell Publishing Ltd. - 2047-9980. ; 11:4
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Five classic thrombophilias have been recognized: factor V Leiden (rs6025), the prothrombin G20210A variant (rs1799963), and protein C, protein S, and antithrombin deficiencies. This study aimed to determine the thrombotic risk of classic thrombophilias in a cohort of middle-aged and older adults. METHODS AND RESULTS: Factor V Leiden, prothrombin G20210A and protein-coding variants in the PROC (protein C), PROS1 (protein S), and SERPINC1 (antithrombin) anticoagulant genes were determined in 29 387 subjects (born 1923–1950, 60% women) who participated in the Malmö Diet and Cancer study (1991–1996). The Human Gene Mutation Database was used to define 68 disease-causing mutations. Patients were followed up from baseline until the first event of venous thromboembolism (VTE), death, or Dec 31, 2018. Carriership (n=908, 3.1%) for disease-causing mutations in the PROC, PROS1, and SERPINC1 genes was associated with incident VTE: Hazard ratio (HR) was 1.6 (95% CI, 1.3–1.9). Variants not in Human Gene Mutation Database were not linked to VTE (HR, 1.1; 95% CI, 0.8–1.5). Heterozygosity for rs6025 and rs1799963 was associated with incident VTE: HR, 1.8 (95% CI, 1.6–2.0) and HR, 1.6 (95% CI, 1.3–2.0), respectively. The HR for carrying 1 classical thrombophilia variant was 1.7 (95% CI, 1.6–1.9). HR was 3.9 (95% CI, 3.1–5.0) for carriers of ≥2 thrombophilia variants. CONCLUSIONS: The 5 classic thrombophilias are associated with a dose-graded risk of VTE in middle-aged and older adults. Disease-causing variants in the PROC, PROS1, and SERPINC1 genes were more common than the rs1799963 variant but the conferred genetic risk was comparable with the rs6025 and rs1799963 variants.
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| 43. |
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| 44. |
- Manderstedt, Eric, et al.
(författare)
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Thrombomodulin (THBD) gene variants and thrombotic risk in a population-based cohort study
- 2022
-
Ingår i: Journal of Thrombosis and Haemostasis. - : Elsevier BV. - 1538-7933 .- 1538-7836. ; 20:4, s. 929-935
-
Tidskriftsartikel (refereegranskat)abstract
- Background: The protein C anticoagulant system plays a key role in maintaining the hemostatic balance. Although several studies have identified thrombomodulin gene (THBD) variants among venous thromboembolism (VTE) patients, the role of THBD in relation to VTE in humans remains to be clarified. Objectives: This study aimed to determine the thrombotic risk of rare and common THBD variants in a large population-based cohort of middle-aged and older adults. Patients/Methods: The exome sequence of THBD was analyzed for qualifying variants in 28,794 subjects (born 1923–1950, 60% women), who participated in the Malmö Diet and Cancer study (1991–1996). Patients were followed from baseline until the first event of VTE, death, or 2018. Qualifying variants were defined as loss-of-function or non-benign (PolyPhen-2) missense variants with minor allele frequency <0.1%. Results: The single common coding variant rs1042579 was not associated with incident VTE. Sixteen rare variants were classified as qualifying and included in collapsing analysis. Seven individuals with VTE compared to 24 individuals without VTE carried one qualifying variant. Cox multivariate regression analysis adjusted for age, sex, body mass index, systolic blood pressure, smoking and alcohol consumption, rs6025, rs1799963, and the top two eigenvectors from a principal components analysis showed a hazard ratio of 3.0 (95% confidence interval 1.4–6.3) for the rare qualifying variants. The distributions of qualifying variants in THBD showed a difference for individuals with and without incident VTE indicating a possible position effect. Conclusions: Rare qualifying THBD variants were associated with VTE, suggesting that rare variants in THBD contribute to development of VTE.
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| 45. |
- Manderstedt, Eric, et al.
(författare)
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Thrombotic Risk Determined by Protein C Receptor (PROCR) Variants among Middle-Aged and Older Adults : A Population-Based Cohort Study
- 2022
-
Ingår i: Thrombosis and Haemostasis. - : Georg Thieme Verlag KG. - 0340-6245 .- 2567-689X. ; 122:8, s. 1326-1332
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Tidskriftsartikel (refereegranskat)abstract
- Background The protein C (PC) anticoagulant system has a key role in maintaining hemostatic balance. One missense (Ser219Gly) variant in the PC receptor (PROCR) was associated with venous thromboembolism (VTE) in genome-wide association studies. Objectives This study aimed to determine the thrombotic risk of rare and common PROCR variants in a large population-based cohort of middle-aged and older adults. Methods The exonic sequence of PROCR was analyzed for the Ser219Gly variant and other qualifying variants in 28,794 subjects (born 1923-1950, 60% women) without previous VTE, who participated in the Malmö Diet and Cancer study (1991-1996). Incidence of VTE was followed up until 2018. Qualifying variants were defined as loss-of-function or nonbenign (PolyPhen-2) missense variants with minor allele frequencies (MAFs) <0.1%. Results Re-sequencing identified 36 PROCR variants in the study population (26,210 non-VTE exomes and 2,584 VTE exomes), 11 synonymous, 22 missense, and three loss-of-function variants. Kaplan-Meier analysis of the known Ser219Gly variant (rs867186) showed that homozygosity for this variant increased the risk of disease, whereas heterozygosity showed no effect. Cox multivariate regression analysis revealed an adjusted hazard ratio (HR) of 1.5 (95% confidence interval [CI]: 1.1-2.0). Fifteen rare variants were classified as qualifying and were included in collapsing analysis (burden test and SKAT-O). They did not contribute to risk. However, a Arg113Cys missense variant (rs146420040; MAF = 0.004) showed an increased VTE risk (HR = 1.3; 95% CI: 1.0-1.9). Conclusion Homozygosity for the Ser219Gly variant and a previously identified functional PROCR variant (Arg113Cys) was associated with VTE. Other variants did not contribute to VTE.
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| 46. |
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| 47. |
- Markevich, Vladimir P., et al.
(författare)
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The trivacancy and trivacancy-oxygen family of defects in silicon
- 2014
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Ingår i: Solid State Phenomena. - 1012-0394 .- 1662-9779. ; 205-206, s. 181-190
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Tidskriftsartikel (refereegranskat)abstract
- The data obtained recently from combined deep-level-transient spectroscopy (DLTS), local vibrational mode (LVM) spectroscopy and ab-initio modeling studies on structure, electronic properties, local vibrational modes, reconfiguration and diffusion paths and barriers for trivacancy (V3) and trivacancy-oxygen (V3O) defects in silicon are summarized. New experimental results on the introduction rates of the divacancy (V2) and trivacancy upon 4 MeV electron irradiation and on the transformation of V3 from the fourfold coordinated configuration to the (110) planar one upon minority carrier injection are reported. Possible mechanisms of the transformation are considered and discussed.
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| 48. |
- Moberg, Christina, et al.
(författare)
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De unga gör helt rätt när de stämmer staten
- 2022
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Ingår i: Aftonbladet. - 1103-9000.
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- 1 620 forskare och lärare i forskarvärlden: Vi ställer oss bakom Auroras klimatkrav
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| 49. |
- Mortazavi, A. N., et al.
(författare)
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Exploring failure modes of alumina scales on FeCrAl and FeNiCrAl alloys in a nitriding environment
- 2020
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Ingår i: Acta Materialia. - : Elsevier BV. - 1359-6454. ; 201, s. 131-146
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Tidskriftsartikel (refereegranskat)abstract
- Two high-temperature FeCrAl and FeNiCrAl alloys were exposed in a strongly nitriding environment at 900 °C and the morphology of nitridation was studied. Quasi-in-situ experiments revealed that nitridation started at specific surface sites directly related to the alloy microstructure where the alumina scale was permeable to nitrogen. FeCrAl alloy grains with (112) orientation formed outward-growing alumina scales and were susceptible to nitridation. Outward-growing scales and substrate nitridation was also observed at chromium carbide precipitates in the FeNiCrAl alloy. Both alloys suffered nitridation at reactive element-rich (Y and Zr) inclusions larger than a certain critical size. The latter type of attack is caused by cracks and pores in the scale. The findings open new avenues of research for developing the next generation of high temperature alloys with superior properties.
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| 50. |
- Nielsen, A.T., et al.
(författare)
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Hydrogen production from organic waste
- 2001
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Ingår i: International journal of hydrogen energy. - 0360-3199 .- 1879-3487. ; 26:6, s. 547-550
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Tidskriftsartikel (refereegranskat)abstract
- The extraction of pure hydrogen from the fermentation of household waste by a mixed anaerobic bacterial flora is demonstrated. Simulated household waste (600 g) was fermented in a bioreactor, which was continuously sparged with nitrogen (30 ml/min) fed in from the bottom. The gas stream from the biorector passes through a sulphide trap (ZnO) and then through a heated palladium-silver membrane reactor to separate hydrogen from the gas stream. In this way, waste remediation and biological hydrogen production is combined in a process where a large proportion of the hydrogen produced can be collected, free of other gaseous species from the fermentation. © 2001 International Association for Hydrogen Energy.
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