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1.	Estrada, Karol, et al. (författare) Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. 2012 Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 44:5, s. 491-501 Tidskriftsartikel (refereegranskat)abstract Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide association studies and 32,961 individuals of European and east Asian ancestry. We tested the top BMD-associated markers for replication in 50,933 independent subjects and for association with risk of low-trauma fracture in 31,016 individuals with a history of fracture (cases) and 102,444 controls. We identified 56 loci (32 new) associated with BMD at genome-wide significance (P < 5 × 10(-8)). Several of these factors cluster within the RANK-RANKL-OPG, mesenchymal stem cell differentiation, endochondral ossification and Wnt signaling pathways. However, we also discovered loci that were localized to genes not known to have a role in bone biology. Fourteen BMD-associated loci were also associated with fracture risk (P < 5 × 10(-4), Bonferroni corrected), of which six reached P < 5 × 10(-8), including at 18p11.21 (FAM210A), 7q21.3 (SLC25A13), 11q13.2 (LRP5), 4q22.1 (MEPE), 2p16.2 (SPTBN1) and 10q21.1 (DKK1). These findings shed light on the genetic architecture and pathophysiological mechanisms underlying BMD variation and fracture susceptibility.
2.	Wuttke, Matthias, et al. (författare) A catalog of genetic loci associated with kidney function from analyses of a million individuals 2019 Ingår i: Nature Genetics. - : NATURE PUBLISHING GROUP. - 1061-4036 .- 1546-1718. ; 51:6, s. 957-972 Tidskriftsartikel (refereegranskat)abstract Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.
3.	Attia, Zachi I., et al. (författare) Rapid Exclusion of COVID Infection With the Artificial Intelligence Electrocardiogram 2021 Ingår i: Mayo Clinic proceedings. - : ELSEVIER SCIENCE INC. - 0025-6196 .- 1942-5546. ; 96:8, s. 2081-2094 Tidskriftsartikel (refereegranskat)abstract Objective: To rapidly exclude severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection using artificial intelligence applied to the electrocardiogram (ECG). Methods: A global, volunteer consortium from 4 continents identified patients with ECGs obtained around the time of polymerase chain reaction-confirmed COVID-19 diagnosis and age- and sex-matched controls from the same sites. Clinical characteristics, polymerase chain reaction results, and raw electrocardiographic data were collected. A convolutional neural network was trained using 26,153 ECGs (33.2% COVID positive), validated with 3826 ECGs (33.3% positive), and tested on 7870 ECGs not included in other sets (32.7% positive). Performance under different prevalence values was tested by adding control ECGs from a single high-volume site. Results: The area under the curve for detection of acute COVID-19 infection in the test group was 0.767 (95% CI, 0.756 to 0.778; sensitivity, 98%; specificity, 10%; positive predictive value, 37%; negative predictive value, 91%). To more accurately reflect a real-world population, 50,905 normal controls were added to adjust the COVID prevalence to approximately 5% (2657/58,555), resulting in an area under the curve of 0.780 (95% CI, 0.771 to 0.790) with a specificity of 12.1% and a negative predictive value of 99.2%. Conclusion: Infection with SARS-CoV-2 results in electrocardiographic changes that permit the artificial intelligence-enhanced ECG to be used as a rapid screening test with a high negative predictive value (99.2%). This may permit the development of electrocardiography-based tools to rapidly screen individuals for pandemic control. (C) 2021 Mayo Foundation Medical Education and Research
4.	Saxena, Richa, et al. (författare) Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels 2007 Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 316:5829, s. 1331-1336 Tidskriftsartikel (refereegranskat)abstract New strategies for prevention and treatment of type 2 diabetes (T2D) require improved insight into disease etiology. We analyzed 386,731 common single-nucleotide polymorphisms (SNPs) in 1464 patients with T2D and 1467 matched controls, each characterized for measures of glucose metabolism, lipids, obesity, and blood pressure. With collaborators (FUSION and WTCCC/UKT2D), we identified and confirmed three loci associated with T2D - in a noncoding region near CDKN2A and CDKN2B, in an intron of IGF2BP2, and an intron of CDKAL1 - and replicated associations near HHEX and in SLC30A8 found by a recent whole-genome association study. We identified and confirmed association of a SNP in an intron of glucokinase regulatory protein (GCKR) with serum triglycerides. The discovery of associated variants in unsuspected genes and outside coding regions illustrates the ability of genome-wide association studies to provide potentially important clues to the pathogenesis of common diseases.
5.	Svensson, Johan, 1964, et al. (författare) Growth hormone (GH) replacement therapy in GH deficient adults: predictors of one-year metabolic and clinical response. 2007 Ingår i: Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. - : Elsevier BV. - 1096-6374 .- 1532-2238. ; 17:1, s. 67-76 Tidskriftsartikel (refereegranskat)abstract OBJECTIVE: This study investigated whether baseline status could predict the responsiveness to one-year growth hormone (GH) replacement therapy in adult GH deficient (GHD) patients. DESIGN: A total of 380 European patients with adult onset GHD due to non-functioning pituitary adenoma that had been enrolled in Pfizer International Metabolic Database (KIMS), and that had completed one year of GH replacement therapy within KIMS, were studied. RESULTS: The mean initial dose of GH was 0.22 (SEM 0.01) mg/day and after one year, the mean dose was 0.36 (0.01) mg/day. The mean insulin-like growth factor-I (IGF-I) SD score increased from -1.75 (0.08) at baseline to 0.47 (0.05) after one year. Quality of life (QoL)-Assessment of GHD in Adults (QoL-AGHDA), waist circumference, waist:hip ratio, and serum lipid pattern improved. Women received a higher dose of GH than men after one year, and demonstrated similar treatment response. In multiple stepwise forward regression analyses, the one-year changes in QoL-AGHDA score, waist:hip ratio, and serum low density lipoprotein-cholesterol (LDL-C) level correlated inversely with the baseline values of the same variable. In addition, the change after one year in QoL-AGHDA score correlated inversely with duration of hypopituitarism and baseline serum high density lipoprotein-cholesterol (HDL-C) level, and the change in waist:hip ratio correlated inversely, although more weakly, with baseline serum HDL-C level and UK citizenship and positively with baseline waist circumference and the initial GH dose. The change in serum LDL-C level additionally correlated inversely with the mean GH dose and duration of hypopituitarism and positively with UK citizenship. CONCLUSIONS: Baseline status could, with moderate strength, predict the responsiveness in the same variable whereas it could not, or only weakly, predict the response in other variables. Therefore, when the decision to start GH replacement is undertaken, as many outcome variables as possible should be evaluated in order to adequately evaluate the likelihood of clinical benefit. Finally, women have a similar response to GH replacement as men when individualised GH dosing schedules are employed and should therefore be selected for GH therapy to a similar extent.
6.	Svensson, Thomas, et al. (författare) Association of Sleep Duration with All- And Major-Cause Mortality among Adults in Japan, China, Singapore, and Korea 2021 Ingår i: JAMA Network Open. - : American Medical Association (AMA). - 2574-3805. ; 4:9 Tidskriftsartikel (refereegranskat)abstract Importance: The association between long sleep duration and mortality appears stronger in East Asian populations than in North American or European populations. Objectives: To assess the sex-specific association between sleep duration and all-cause and major-cause mortality in a pooled longitudinal cohort and to stratify the association by age and body mass index. Design, Setting, and Participants: This cohort study of individual-level data from 9 cohorts in the Asia Cohort Consortium was performed from January 1, 1984, to December 31, 2002. The final population included participants from Japan, China, Singapore, and Korea. Mean (SD) follow-up time was 14.0 (5.0) years for men and 13.4 (5.3) years for women. Data analysis was performed from August 1, 2018, to May 31, 2021. Exposures: Self-reported sleep duration, with 7 hours as the reference category. Main Outcomes and Measures: Mortality, including deaths from all causes, cardiovascular disease, cancer, and other causes. Sex-specific hazard ratios (HRs) and 95% CIs were estimated using Cox proportional hazards regression with shared frailty models adjusted for age and the key self-reported covariates of marital status, body mass index, smoking status, alcohol consumption, physical activity, history of diabetes and hypertension, and menopausal status (for women). Results: For 322721 participants (mean [SD] age, 54.5 [9.2] years; 178542 [55.3%] female), 19419 deaths occurred among men (mean [SD] age of men, 53.6 [9.0] years) and 13768 deaths among women (mean [SD] age of women, 55.3 [9.2] years). A sleep duration of 7 hours was the nadir for associations with all-cause, cardiovascular disease, and other-cause mortality in both men and women, whereas 8 hours was the mode sleep duration among men and the second most common sleep duration among women. The association between sleep duration and all-cause mortality was J-shaped for both men and women. The greatest association for all-cause mortality was with sleep durations of 10 hours or longer for both men (hazard ratio [HR], 1.34; 95% CI, 1.26-1.44) and women (HR, 1.48; 95% CI, 1.36-1.61). Sex was a significant modifier of the association between sleep duration and mortality from cardiovascular disease (χ25= 13.47, P =.02), cancer (χ25= 16.04, P =.007), and other causes (χ25= 12.79, P =.03). Age was a significant modifier of the associations among men only (all-cause mortality: χ25= 41.49, P <.001; cancer: χ25= 27.94, P <.001; other-cause mortality: χ25= 24.51, P <.001). Conclusions and Relevance: The findings of this cohort study suggest that sleep duration is a behavioral risk factor for mortality in both men and women. Age was a modifier of the association between sleep duration in men but not in women. Sleep duration recommendations in these populations may need to be considered in the context of sex and age.
7.	Zheng, Hou-Feng, et al. (författare) Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture 2015 Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 526:7571, s. 112- Tidskriftsartikel (refereegranskat)abstract The extent to which low-frequency (minor allele frequency (MAF) between 1-5%) and rare (MAF <= 1%) variants contribute to complex traits and disease in the general population is mainly unknown. Bone mineral density (BMD) is highly heritable, a major predictor of osteoporotic fractures, and has been previously associated with common genetic variants(1-8), as well as rare, population specific, coding variants(9). Here we identify novel non-coding genetic variants with large effects on BMD (n(total) = 53,236) and fracture (n(total) = 508,253) in individuals of European ancestry from the general population. Associations for BMD were derived from whole-genome sequencing (n = 2,882 from UK10K (ref. 10); a population-based genome sequencing consortium), whole-exome sequencing (n = 3,549), deep imputation of genotyped samples using a combined UK10K/1000 Genomes reference panel (n = 26,534), and de novo replication genotyping (n = 20,271). We identified a low-frequency non-coding variant near a novel locus, EN1, with an effect size fourfold larger than the mean of previously reported common variants for lumbar spine BMD8 (rs11692564(T), MAF51.6%, replication effect size510.20 s.d., P-meta = 2 x 10(-14)), which was also associated with a decreased risk of fracture (odds ratio = 0.85; P = 2 x 10(-11); ncases = 98,742 and ncontrols = 409,511). Using an En1cre/flox mouse model, we observed that conditional loss of En1 results in low bone mass, probably as a consequence of high bone turnover. We also identified a novel low frequency non-coding variant with large effects on BMD near WNT16 (rs148771817(T), MAF = 1.2%, replication effect size +10.41 s.d., P-meta = 1 x 10(-11)). In general, there was an excess of association signals arising from deleterious coding and conserved non-coding variants. These findings provide evidence that low-frequency non-coding variants have large effects on BMD and fracture, thereby providing rationale for whole-genome sequencing and improved imputation reference panels to study the genetic architecture of complex traits and disease in the general population.
8.	Adinoyi, Abdulkareem, et al. (författare) EU FP6 IST-2003-507581 WINNER, D3.1 Description of identified new relay based radio network deployment, Oct 2004 2004 Rapport (övrigt vetenskapligt/konstnärligt)abstract In D3.1 the first concept for a WINNER radio network deployment mainly focused on relay basedconcepts are proposed. Further the concept of an radio and protocol architecture is presented that takes upthe relaying approach as well as the idea of having different WINNER radio interface modes to servedifferent user and usage scenarios in an optimal manner. Thereby the presented protocol concept is basedon generic and mode specific user an control plane functionalities, where the common functions fordifferent modes are generalised and provide a common interface towards upper layer functions/protocols.Further some relaying concepts for urban hot area coverage including mesh networks are presentedaccompanied by promising simulation results. In addition to the relaying concepts benchmarks have beenproduced to allow a comparison of new concepts against today’s systems.
9.	Adler, John, et al. (författare) Effects of Early Life Conditions on Social Mobility in Southern Sweden 1766-1894 2003 Konferensbidrag (refereegranskat)
10.	Ali, Muhammad, et al. (författare) Leveraging large multi-center cohorts of Alzheimer disease endophenotypes to understand the role of Klotho heterozygosity on disease risk. 2022 Ingår i: PloS one. - : Public Library of Science (PLoS). - 1932-6203. ; 17:5 Tidskriftsartikel (refereegranskat)abstract Two genetic variants in strong linkage disequilibrium (rs9536314 and rs9527025) in the Klotho (KL) gene, encoding a transmembrane protein, implicated in longevity and associated with brain resilience during normal aging, were recently shown to be associated with Alzheimer disease (AD) risk in cognitively normal participants who are APOE ε4 carriers. Specifically, the participants heterozygous for this variant (KL-SVHET+) showed lower risk of developing AD. Furthermore, a neuroprotective effect of KL-VSHET+ has been suggested against amyloid burden for cognitively normal participants, potentially mediated via the regulation of redox pathways. However, inconsistent associations and a smaller sample size of existing studies pose significant hurdles in drawing definitive conclusions. Here, we performed a well-powered association analysis between KL-VSHET+ and five different AD endophenotypes; brain amyloidosis measured by positron emission tomography (PET) scans (n = 5,541) or cerebrospinal fluid Aβ42 levels (CSF; n = 5,093), as well as biomarkers associated with tau pathology: the CSF Tau (n = 5,127), phosphorylated Tau (pTau181; n = 4,778) and inflammation: CSF soluble triggering receptor expressed on myeloid cells 2 (sTREM2; n = 2,123) levels. Our results found nominally significant associations of KL-VSHET+ status with biomarkers for brain amyloidosis (e.g., CSF Aβ positivity; odds ratio [OR] = 0.67 [95% CI, 0.55-0.78], β = 0.72, p = 0.007) and tau pathology (e.g., biomarker positivity for CSF Tau; OR = 0.39 [95% CI, 0.19-0.77], β = -0.94, p = 0.007, and pTau; OR = 0.50 [95% CI, 0.27-0.96], β = -0.68, p = 0.04) in cognitively normal participants, 60-80 years old, who are APOE e4-carriers. Our work supports previous findings, suggesting that the KL-VSHET+ on an APOE ε4 genotype background may modulate Aβ and tau pathology, thereby lowering the intensity of neurodegeneration and incidence of cognitive decline in older controls susceptible to AD.
11.	Anderson, John B, et al. (författare) Coded Modulation Systems 2003 Ingår i: Kluwer Academic / Plenum Publishers. - 0306472791 Bok (övrigt vetenskapligt/konstnärligt)abstract This textbook studies the 3 main types of coded modulation: trellis-coded modulation (TCM), continuous-phase modulation (CPM) codes, and linear modulation codes like those that arise from filtering and intersymbol interference. In 2 final chapters, code-division multiple-access receivers are discussed. The book begins with a review of coding, modulation and information theory.
12.	Andersson, Svante, 1962-, et al. (författare) Sustainable development considerations in supply chains : Firms' relationships with stakeholders in their business sustainability practices—A triangular comparison 2022 Ingår i: Business Strategy and the Environment. - Oxford : John Wiley & Sons. - 0964-4733 .- 1099-0836. ; 32:4, s. 1885-1899 Tidskriftsartikel (refereegranskat)abstract This study aims to investigate focal firms' business sustainability relationships in connection with their stakeholders in supply chain networks. A questionnaire survey was sent to a sample consisting of large Swedish firms, with 107 usable questionnaires returned. The results reveal which stakeholders are of interest for firms in sustainability efforts. The results are compared with earlier findings from Norway and Spain in a triangular approach. The former is a similar country, while the latter is different to Sweden in several ways. In addition, the study uncovers which stakeholders in the supply chain network should be considered. The study also demonstrates how firms can implement business sustainability in their supply chain networks and shows the extent to which different stakeholders are considered in sustainability efforts. The study contributes to sustainability research and stakeholder theory in supply chain networks. Opposite to earlier findings, this study showed only minor influences from national culture and institutions on firms' sustainable business practices in supply chain networks. © 2022 The Authors. Business Strategy and The Environment published by ERP Environment and John Wiley & Sons Ltd.
13.	Andersson, Svante, 1962-, et al. (författare) Sustainable development—Direct and indirect effects between economic, social, and environmental dimensions in business practices 2022 Ingår i: Corporate Social Responsibility and Environmental Management. - Oxford : John Wiley & Sons. - 1535-3958 .- 1535-3966. ; 29:5, s. 1158-1172 Tidskriftsartikel (refereegranskat)abstract This study investigates the direct and indirect effects between economic, social and environmental dimensions of triple bottom line (TBL), based on a questionnaire survey and cross-industrial sample in Sweden. The analyses apply partial least squares structural equation models. The study tests the direct and indirect effects between economic, social, and environmental dimensions of TBL and offers additional validity and reliability to establish the measurement and structural properties between the dimensions of TBL. The study extends earlier findings by explicitly discussing how the three TBL goals relate to each other and shows how the dynamic capability view can be a fruitful lens to investigate business sustainability. Some differences in sustainability business practices caused by differences in national cultures are identified. Sustainability reporting in a strong uncertainty avoidance (UA) country happens in accordance with regulations and laws. Conversely, for weak UA cultures, reporting and compliance with regulations are ways to build trust with stakeholders. That is, reporting is more transparent and widespread in weak UA countries. The study also provides a foundation to guide companies' actions of business sustainability. The model shows companies how to establish the order of actions undertaken across economic, social, and environmental dimensions. In addition, it clarifies that the economic dimension exerts an effect on the social and environmental dimensions. The model also grasps long-term economic performance by including competitiveness and brand value, while earlier research mainly has focused on more short-term measurements as return on assets. © 2022 The Authors. Corporate Social Responsibility and Environmental Management published by ERP Environment and John Wiley & Sons Ltd.
14.	Andersson, Tommy, et al. (författare) 2021 års ekonomipris till David Card, Joshua Angrist och Guido Imbens 2021 Ingår i: Ekonomisk Debatt. - 0345-2646. ; 49:8, s. 5-17 Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
15.	Apergis-Schoute, John, et al. (författare) Editorial : Neuronal Co-transmission 2019 Ingår i: Frontiers in Neural Circuits. - : FRONTIERS MEDIA SA. - 1662-5110. ; 13 Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
16.	Arts, Thomas, 1969, et al. (författare) Accelerating race condition detection through procrastination 2011 Ingår i: Proceedings of the 2011 ACM SIGPLAN Erlang Workshop, Tokyo, 23 September 2011. - New York, NY, USA : ACM. - 9781450308595 ; , s. 14-22 Konferensbidrag (refereegranskat)abstract Race conditions are notoriously frustrating to find, and good tools can help. The main difficulty is reliably provoking the race condition. In previous work we presented a randomising scheduler for Erlang that helps with this task. In a language without pervasive shared mutable state, such as Erlang, performing scheduling decisions at random uncovers race conditions surprisingly well. However, it is not always enough. We describe a technique, procrastination, that aims to provoke race conditions more often than by random scheduling alone. It works by running the program and looking for pairs of events that might interfere, such as two message sends to the same process. Having found such a pair of events, we re-run the program but try to provoke a race condition by reversing the order of the two events. We apply our technique to a piece of industrial Erlang code. Compared to random scheduling alone, procrastination allows us to find minimal failing test cases more reliably and more quickly.
17.	Arts, Thomas, 1969, et al. (författare) Testing AUTOSAR software with QuickCheck 2015 Ingår i: 2015 IEEE 8th International Conference on Software Testing, Verification and Validation Workshops, ICSTW 2015 - Proceedings. - 2159-4848. - 9781479918850 Konferensbidrag (refereegranskat)abstract AUTOSAR (AUTomotive Open System ARchitecture) is an evolving standard for embedded software in vehicles, defined by the automotive industry, and implemented by many different vendors. On behalf of Volvo Cars, we have developed model-based acceptance tests for some critical AUTOSAR components, to guarantee that implementations from different vendors are compatible. We translated over 3000 pages of textual specifications into QuickCheck models, and tested many different implementations using large volumes of generated tests. This exposed over 200 issues, which we raised with Volvo and the software vendors. Compared to an earlier manual approach, ours is more efficient, more effective, and more correct.
18.	Arts, Thomas, 1969, et al. (författare) Testing Implementations of Formally Verified Algorithms 2005 Ingår i: Proceedings of the 5th Conference on Software Engineering Research and Practice in Sweden. Konferensbidrag (refereegranskat)abstract Algorithms described in literature can often be used to solvepractical, industrial problems. In safety-critical industrialsettings, algorithms that have been formally verified should be evenmore attractive candidates for implementations. Nevertheless, weobserve little transfer of algorithms from research papers intoproducts. In this paper we describe a case study on the implementationof algorithms for the widely known and broadly studied problem ofleader election. Despite thousands of articles on that topic, itstill requires a lot of engineering to select the relevant articles,and get a correct algorithm implemented in an industrial setting.Modifications are necessary to meet all requirements. We proposeadaptation and testing of formal properties as a realistic and cheap way tocheck the correctness of the modifications, since performing a formalproof seems unrealistic for industrial systems. We show how we use theproperties stated in the articles to guide our tests.
19.	Becker, Magnus, et al. (författare) Millard repair of unilateral isolated cleft lip: a 25-year follow-up 1998 Ingår i: Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery. - : Informa UK Limited. - 1651-2073 .- 0284-4311. ; 32:4, s. 387-394 Tidskriftsartikel (refereegranskat)abstract Twenty-five patients with isolated unilateral cleft lip took part in a follow-up study at a mean age of 28.6 years. All had had a primary, Millard lip repair, at a mean age of 4.6 months. In 20 patients, at least one secondary correction had been undertaken during adolescence. The overall long-term outcome was thought to be good, leaving a fairly inconspicuous fine lip scar and acceptable nose configuration. In half the patients, however, the lip was slightly elongated and the nostrils were still asymmetrical. These findings concurred with the patients' subjective assessments, which showed that appearance of the lip and nose were rated good by 20 (80%) and 16 (64%), respectively. The findings of this study provide a baseline for future evaluation of the results achieved with lip closure by Johanson's technique.
20.	Bergman, Eva, et al. (författare) Synthesis of theoretical and empirical experineces from nutrient and cyprinid reductions in Lake Ringsjön 1999 Ingår i: Hydrobiologia. - 0018-8158. ; 404, s. 145-156 Tidskriftsartikel (refereegranskat)abstract The reduction in external phosphorus load to Lake Ringsjön during the 1980s, did not result in improved water transparency during the following ten-year period. Furthermore, a fish-kill in the Eastern Basin of the lake, in addition to a cyprinid reduction programme (biomanipulation; 1988–1992), in contrast to theory, did not lead to any increase in zooplankton biomass or size. This absence of response in the pelagic food chain may have been attributed to the increase in abundance of YOY (0+) fish, following the fish reduction programme. Despite the lack of effect on zooplankton, there was a decrease in phytoplankton biomass, a change in species composition and an increase in water transparency following biomanipulation. In 1989, one year after the fish-kill in Eastern Basin, the Secchi depth (summer mean) increased from 60 cm to 110 cm. In the following years, water transparency increased further, despite an increase in phosphorus loading. An unexpected effect of the biomanipulation was an increase in benthic invertebrate and staging waterfowl abundances, which occurred 2–4 years after fish reduction. Hence, the response in the benthic community following biomanipulation was considerably stronger than in the pelagic community. A likely explanation is that reduction in abundance of the benthic feeding fish species bream (Abramis brama), strongly affected the benthic invertebrate fauna. In this paper, we present what we believe happened in Lake Ringsjön, and which processes are likely to have been important at various stages of the restoration process.
21.	Birkebaek, Niels H., et al. (författare) Impact of the COVID-19 pandemic on long-term trends in the prevalence of diabetic ketoacidosis at diagnosis of paediatric type 1 diabetes: an international multicentre study based on data from 13 national diabetes registries 2022 Ingår i: The Lancet Diabetes and Endocrinology. - : ELSEVIER SCIENCE INC. - 2213-8587 .- 2213-8595. ; 10:11, s. 786-794 Tidskriftsartikel (refereegranskat)abstract Background An increased prevalence of diabetic ketoacidosis at diagnosis of type 1 diabetes in children was observed in various diabetes centres worldwide during the COVID-19 pandemic. We aimed to evaluate trends in the prevalence of diabetic ketoacidosis at diagnosis of paediatric type 1 diabetes before and during the COVID-19 pandemic, and to identify potential predictors of changes in diabetic ketoacidosis prevalence during the pandemic.Methods For this international multicentre study, we used data from 13 national diabetes registries (Australia, Austria, Czechia, Denmark, Germany, Italy, Luxembourg, New Zealand, Norway, Slovenia, Sweden, USA [Colorado], and Wales). The study population comprised 104 290 children and adolescents aged 6 months to younger than 18 years, who were diagnosed with type 1 diabetes between Jan 1, 2006, and Dec 31, 2021. The observed diabetic ketoacidosis prevalence in 2020 and 2021 was compared to predictions based on trends over the pre-pandemic years 2006-19. Associations between changes in diabetic ketoacidosis prevalence and the severity of the COVID-19 pandemic and containment measures were examined with excess all-cause mortality in the whole population and the Stringency Index from the Oxford COVID-19 Government Response Tracker.Findings 87 228 children and adolescents were diagnosed with type 1 diabetes between 2006 and 2019, 8209 were diagnosed in 2020, and 8853 were diagnosed in 2021. From 2006 to 2019, diabetic ketoacidosis at diagnosis of type 1 diabetes was present in 23 775 (27middot3%) of 87 228 individuals and the mean annual increase in the prevalence of diabetic ketoacidosis in the total cohort from 2006 to 2019 was 1middot6% (95% CI 1middot3 to 1middot9). The adjusted observed prevalence of diabetic ketoacidosis at diagnosis of type 1 diabetes was 39middot4% (95% CI 34middot0 to 45middot6) in 2020 and 38middot9% (33middot6 to 45middot0) in 2021, significantly higher than the predicted prevalence of 32middot5% (27middot8 to 37middot9) for 2020 and 33middot0% (28middot3 to 38middot5) for 2021 (p<0middot0001 for both years). The prevalence of diabetic ketoacidosis was associated with the pandemic containment measures, with an estimated risk ratio of 1middot037 (95% CI 1middot024 to 1middot051; p<0middot0001) per ten-unit increase in the Stringency Index for 2020 and 1middot028 (1middot009 to 1middot047; p=0middot0033) for 2021, but was not significantly associated with excess all-cause mortality.Interpretation During the COVID-19 pandemic, there was a marked exacerbation of the pre-existing increase in diabetic ketoacidosis prevalence at diagnosis of type 1 diabetes in children. This finding highlights the need for early and timely diagnosis of type 1 diabetes in children and adolescents.Funding German Federal Ministry for Education and Research, German Robert Koch Institute, German Diabetes Association, German Diabetes Foundation, Slovenian Research Agency, Welsh Government, Central Denmark Region, and Swedish Association of Local Authorities and Regions.Copyright (c) 2022 Elsevier Ltd. All rights reserved.
22.	Björk, Magnus, 1977, et al. (författare) Exposed Datapath for Efficient Computing 2006 Rapport (övrigt vetenskapligt/konstnärligt)abstract We introduce FlexCore, which is the first exemplar of a processor based on the FlexSoC processor paradigm. TheFlexCore utilizes an exposed datapath for increased performance. Microbenchmarks yield a performance boost of a factor of two over a traditional five-stage pipeline with the same functional units as the FlexCore.We describe our approach to compiling for the FlexCore.A flexible interconnect allows the FlexCore datapath to bedynamically reconfigured as a consequence of code generation. Additionally, specialized functional units may be introduced and utilized within the same architecture and compilation framework. The exposed datapath requires a wide control word. The conducted evaluation of two micro benchmarks confirms that this increases the instruction bandwidth and memory footprint. This calls for an efficient instruction decoding as proposed in the FlexSoC paradigm.
23.	Björk, Magnus, 1977, et al. (författare) Exposed Datapath for Efficient Computing 2007 Ingår i: 2007 HiPEAC Workshop on Reconfigurable Computing. Konferensbidrag (refereegranskat)
24.	Bohlooly-Yeganeh, Mohammad, 1966, et al. (författare) Growth hormone overexpression in the central nervous system results in hyperphagia-induced obesity associated with insulin resistance and dyslipidemia. 2005 Ingår i: Diabetes. - 0012-1797 .- 1939-327X. ; 54:1, s. 51-62 Tidskriftsartikel (refereegranskat)abstract It is well known that peripherally administered growth hormone (GH) results in decreased body fat mass. However, GH-deficient patients increase their food intake when substituted with GH, suggesting that GH also has an appetite stimulating effect. Transgenic mice with an overexpression of bovine GH in the central nervous system (CNS) were created to investigate the role of GH in CNS. This study shows that overexpression of GH in the CNS differentiates the effect of GH on body fat mass from that on appetite. The transgenic mice were not GH-deficient but were obese and showed increased food intake as well as increased hypothalamic expression of agouti-related protein and neuropeptide Y. GH also had an acute effect on food intake following intracerebroventricular injection of C57BL/6 mice. The transgenic mice were severely hyperinsulinemic and showed a marked hyperplasia of the islets of Langerhans. In addition, the transgenic mice displayed alterations in serum lipid and lipoprotein levels and hepatic gene expression. In conclusion, GH overexpression in the CNS results in hyperphagia-induced obesity indicating a dual effect of GH with a central stimulation of appetite and a peripheral lipolytic effect.
25.	Borg, Markus, et al. (författare) From LiDAR to Underground Maps via 5G - Business Models Enabling a System-of-Systems Approach to Mapping the Kankberg Mine 2017 Rapport (övrigt vetenskapligt/konstnärligt)abstract With ever-increasing productivity targets in mining operations, there is a growing interest in mining automation. The PIMM project addresses the fundamental challenge of network communication by constructing a pilot 5G network in the underground mine Kankberg. In this report, we discuss how such a 5G network could constitute the essential infrastructure to organize existing systems in Kankberg into a system-of-systems (SoS). In this report, we analyze a scenario in which LiDAR equipped vehicles operating in the mine are connected to existing mine mapping and positioning solutions. The approach is motivated by the approaching era of remote controlled, or even autonomous, vehicles in mining operations. The proposed SoS could ensure continuously updated maps of Kankberg, rendered in unprecedented detail, supporting both productivity and safety in the underground mine. We present four different SoS solutions from an organizational point of view, discussing how development and operations of the constituent systems could be distributed among Boliden and external stakeholders, e.g., the vehicle suppliers, the hauling company, and the developers of the mapping software. The four scenarios are compared from both technical and business perspectives, and based on trade-off discussions and SWOT analyses. We conclude our report by recommending continued research along two future paths, namely a closer cooperation with the vehicle suppliers, and further feasibility studies regarding establishing a Kankberg software ecosystem.
26.	Borg, Markus, et al. (författare) Piggybacking on an Autonomous Hauler : Business Models Enabling a System-of-Systems Approach to Mapping an Underground Mine 2017 Ingår i: 2017 IEEE 25TH INTERNATIONAL REQUIREMENTS ENGINEERING CONFERENCE (RE). - : IEEE Press. - 9781538631911 ; , s. 372-381 Konferensbidrag (refereegranskat)abstract With ever-increasing productivity targets in mining operations, there is a growing interest in mining automation. In future mines, remote-controlled and autonomous haulers will operate underground guided by LiDAR sensors. We envision reusing LiDAR measurements to maintain accurate mine maps that would contribute to both safety and productivity. Extrapolating from a pilot project on reliable wireless communication in Boliden's Kankberg mine, we propose establishing a system-of-systems (SoS) with LIDAR-equipped haulers and existing mapping solutions as constituent systems. SoS requirements engineering inevitably adds a political layer, as independent actors are stakeholders both on the system and SoS levels. We present four SoS scenarios representing different business models, discussing how development and operations could be distributed among Boliden and external stakeholders, e.g., the vehicle suppliers, the hauling company, and the developers of the mapping software. Based on eight key variation points, we compare the four scenarios from both technical and business perspectives. Finally, we validate our findings in a seminar with participants from the relevant stakeholders. We conclude that to determine which scenario is the most promising for Boliden, trade-offs regarding control, costs, risks, and innovation must be carefully evaluated.
27.	Bosveld, Fred C., et al. (författare) The Third GABLS Intercomparison Case for Evaluation Studies of Boundary-Layer Models. Part B : Results and Process Understanding 2014 Ingår i: Boundary-layer Meteorology. - : Springer Science and Business Media LLC. - 0006-8314 .- 1573-1472. ; 152:2, s. 157-187 Tidskriftsartikel (refereegranskat)abstract We describe and analyze the results of the third global energy and water cycle experiment atmospheric boundary layer Study intercomparison and evaluation study for single-column models. Each of the nineteen participating models was operated with its own physics package, including land-surface, radiation and turbulent mixing schemes, for a full diurnal cycle selected from the Cabauw observatory archive. By carefully prescribing the temporal evolution of the forcings on the vertical column, the models could be evaluated against observations. We focus on the gross features of the stable boundary layer (SBL), such as the onset of evening momentum decoupling, the 2-m minimum temperature, the evolution of the inertial oscillation and the morning transition. New process diagrams are introduced to interpret the variety of model results and the relative importance of processes in the SBL; the diagrams include the results of a number of sensitivity runs performed with one of the models. The models are characterized in terms of thermal coupling to the soil, longwave radiation and turbulent mixing. It is shown that differences in longwave radiation schemes among the models have only a small effect on the simulations; however, there are significant variations in downward radiation due to different boundary-layer profiles of temperature and humidity. The differences in modelled thermal coupling to the land surface are large and explain most of the variations in 2-m air temperature and longwave incoming radiation among models. Models with strong turbulent mixing overestimate the boundary-layer height, underestimate the wind speed at 200 m, and give a relatively large downward sensible heat flux. The result is that 2-m air temperature is relatively insensitive to turbulent mixing intensity. Evening transition times spread 1.5 h around the observed time of transition, with later transitions for models with coarse resolution. Time of onset in the morning transition spreads 2 h around the observed transition time. With this case, the morning transition appeared to be difficult to study, no relation could be found between the studied processes, and the variation in the time of the morning transition among the models.
28.	Botusan, I. R., et al. (författare) Deficiency of liver-derived insulin-like growth factor-I (IGF-I) does not interfere with the skin wound healing rate 2018 Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 13:3 Tidskriftsartikel (refereegranskat)abstract Objective: IGF-I is a growth factor, which is expressed in virtually all tissues. The circulating IGF-I is however derived mainly from the liver. IGF-I promotes wound healing and its levels are decreased in wounds with low regenerative potential such as diabetic wounds. However, the contribution of circulating IGF-I to wound healing is unknown. Here we investigated the role of systemic IGF-I on wound healing rate in mice with deficiency of liver-derived IGF-I (LI-IGF-I-/- mice) during normal (normoglycemic) and impaired wound healing (diabetes). Methods: LI-IGF-I-/- mice with complete inactivation of the IGF-I gene in the hepatocytes were generated using the Cre/loxP recombination system. This resulted in a 75% reduction of circulating IGF-I. Diabetes was induced with streptozocin in both LI-IGF-I-/- and control mice. Wounds were made on the dorsum of the mice, and the wound healing rate and histology were evaluated. Serum IGF-I and GH were measured by RIA and ELISA respectively. The expression of IGF-I, IGF-II and the IGF-I receptor in the skin were evaluated by qRT-PCR. The local IGF-I protein expression in different cell types of the wounds during wound healing process was analyzed using immunohistochemistry. Results: The wound healing rate was similar in LI-IGF-I-/- mice to that in controls. Diabetes significantly delayed the wound healing rate in both LI-IGF-I-/- and control mice. However, no significant difference was observed between diabetic animals with normal or reduced hepatic IGF-I production. The gene expression of IGF-I, IGF-II and IGF-I receptor in skin was not different between any group of animals tested. Local IGF-I levels in the wounds were similar between of LI-IGF-I-/- and WT mice although a transient reduction of IGF-I expression in leukocytes in the wounds of LI-IGF-I-/- was observed seven days post wounding. Conclusion: Deficiency in the liver-derived IGF-I does not affect wound healing in mice, neither in normo-glycemic conditions nor in diabetes.
29.	Bucardo, Filemon, et al. (författare) Vaccine-derived NSP2 segment in rotaviruses from vaccinated children with gastroenteritis in Nicaragua 2012 Ingår i: Infection, Genetics and Evolution. - : Elsevier. - 1567-1348 .- 1567-7257. ; 12:6, s. 1282-1294 Tidskriftsartikel (refereegranskat)abstract Rotavirus (RV) vaccination programs have been established in several countries using the human-attenuated G1P[8] monovalent vaccine Rotarix (TM) (GlaxoSmithKline) and/or the human-bovine reassortant G1, G2, G3, G4, P[8] pentavalent vaccine Rotaleq (TM) (Merck). The efficacy of both vaccines is high (similar to 90%) in developed countries, but can be remarkably lower in developing countries. For example, a vaccine efficacy against severe diarrhea of only 58% was observed in a 2007-2009 Nicaraguan study using RotaTeq. To gain insight into the significant level of vaccine failure in this country, we sequenced the genomes of RVs recovered from vaccinated Nicaraguan children with gastroenteritis. The results revealed that all had genotype specificities typical for human RVs (11G1P[8], 1G3P[8]) and that the sequences and antigenic epitopes of the outer capsid proteins (VP4 and VP7) of these viruses were similar to those reported for RVs isolated elsewhere in the world. As expected, nine of the G1 P[8] viruses and the single G3P[8] virus had genome constellations typical of human G1 P[8] and G3P[8] RVs: G1/3-P[8]-I1-R1-C1-M1-A1-N1-T1-E1-H1. However, two of the G1P[8] viruses had atypical constellations, G1-P[8]-I1-R1-C1-M1-A1-N2-T1-E1-H1, due to the presence of a genotype-2 NSP2 (N2) gene. The sequence of the N2 NSP2 gene was identical to the bovine N2 NSP2 gene of RotaTeq, indicating that the two atypical viruses originated via reassortment of human G1P[8] RVs with RotaTeq viruses. Together, our data suggest that the high level of vaccine failure in Nicaraguan is probably not due to antigenic drift of commonly circulating virus strains nor the emergence of new antigenetically distinct virus strains. Furthermore, our data suggest that the widespread use of the RotaTeq vaccine has led to the introduction of vaccine genes into circulating human RVs.
30.	Caspersen, Mikael B., et al. (författare) Phosphorylation sites of Arabidopsis MAP kinase substrate 1 (MKS 1) 2007 Ingår i: Biochimica et Biophysica Acta - Proteins and Proteomics. - : Elsevier BV. - 1570-9639. ; 1774:9, s. 1156-1163 Tidskriftsartikel (refereegranskat)abstract The Arabidopsis MAP kinase 4 (MPK4) substrate MKS1 was expressed in Escherichia coli and purified, full-length, 6x histidine (His)-tagged MKS1 was phosphorylated in vitro by hemagglutinin (HA)-tagged MPK4 immuno-precipitated from plants. MKS1 phosphorylation was initially verified by electrophoresis and gel-staining with ProQ Diamond and the protein was digested by either trypsin or chymotrypsin for maximum sequence coverage to facilitate identification of phosphorylated positions. Prior to analysis by mass spectrometry, samples were either desalted, passed over TiO2 or both for improved phosphopeptide detection. As MAP kinases generally phosphorylate serine or threonine followed by proline (Ser/Thr-Pro), theoretical masses of potentially phosphorylated peptides were calculated and mass spectrometric peaks matching these masses were fragmented and searched for a neutral-loss signal at similar to 98 Da indicative of phosphorylation. Additionally, mass spectrometric peaks present in the MPK4-treated MKS1, but not in the control peptide map of untreated MKS1, were fragmented. Fragmentation spectra were subjected to a MASCOT database search which identified three of the twelve Ser-Pro serine residues (Ser72, Set108, Ser120) in the phosphorylated form.
31.	Claessen, Koen, 1975, et al. (författare) Finding Race Conditions in Erlang with QuickCheck and PULSE 2009 Ingår i: ACM SIGPLAN international conference on Functional programming. Konferensbidrag (refereegranskat)
32.	Cosmas, John, et al. (författare) Towards joint communication and sensing (Chapter 4) 2023 Ingår i: Towards Sustainable and Trustworthy 6G: Challenges, Enablers, and Architectural Design. - 9781638282396 ; , s. 121-158 Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract Localization of user equipment (UE) in mobile communication networks has been supported from the early stages of 3rd generation partnership project (3GPP). With 5th Generation (5G) and its target use cases, localization is increasingly gaining importance. Integrated sensing and localization in 6th Generation (6G) networks promise the introduction of more efficient networks and compelling applications to be developed.
33.	Cresswell, Fiona, V, et al. (författare) High-Dose Oral and Intravenous Rifampicin for the Treatment of Tuberculous Meningitis in Predominantly Human Immunodeficiency Virus (HIV)-Positive Ugandan Adults : A Phase II Open-Label Randomized Controlled Trial 2021 Ingår i: Clinical Infectious Diseases. - : Oxford University Press. - 1058-4838 .- 1537-6591. ; 73:5, s. 876-884 Tidskriftsartikel (refereegranskat)abstract Background: High-dose rifampicin may improve outcomes of tuberculous meningitis (TBM). Little safety or pharmacokinetic (PK) data exist on high-dose rifampicin in human immunodeficiency virus (HIV) coinfection, and no cerebrospinal fluid (CSF) PK data exist from Africa. We hypothesized that high-dose rifampicin would increase serum and CSF concentrations without excess toxicity. Methods: In this phase II open-label trial, Ugandan adults with suspected TBM were randomized to standard-of-care control (PO-10, rifampicin 10 mg/kg/day), intravenous rifampicin (IV-20, 20 mg/kg/day), or high-dose oral rifampicin (PO-35, 35 mg/kg/day). We performed PK sampling on days 2 and 14. The primary outcomes were total exposure (AUC(0-24)), maximum concentration (C-max), CSF concentration, and grade 3-5 adverse events. Results: We enrolled 61 adults, 92% were living with HIV, median CD4 count was 50 cells/mu L (interquartile range [IQR] 46-56). On day 2, geometric mean plasma AUC(0-24hr) was 42.9.h mg/L with standard-of-care 10 mg/kg dosing, 249.h mg/L for IV-20 and 327.h mg/L for PO-35 (P<.001). In CSF, standard of care achieved undetectable rifampicin concentration in 56% of participants and geometric mean AUC(0-24hr) 0.27 mg/L, compared with 1.74 mg/L (95% confidence interval [CI] 1.2-2.5) for IV-20 and 2.17 mg/L (1.6-2.9) for PO-35 regimens (P<.001). Achieving CSF concentrations above rifampicin minimal inhibitory concentration (MIC) occurred in 11% (2/18) of standard-of-care, 93% (14/15) of IV-20, and 95% (18/19) of PO-35 participants. Higher serum and CSF levels were sustained at day 14. Adverse events did not differ by dose (P=.34). Conclusions: Current international guidelines result in sub-therapeutic CSF rifampicin concentration for 89% of Ugandan TBM patients. High-dose intravenous and oral rifampicin were safe and respectively resulted in exposures similar to 6- and similar to 8-fold higher than standard of care, and CSF levels above the MIC.
34.	Dahlberg, Anders, et al. (författare) Den nya rödlistan har 746 svampar 2010 Ingår i: Svensk mykologisk tidskrift. - 1653-0357. ; 31:2, s. 37-47 Tidskriftsartikel (refereegranskat)abstract The new Red List that was recently presented by the Swedish Species Information Centre (Gärdenfors 2010) includes 746 species of fungi considered to be threatened. Compared to the previous Red List published in 2005, 36 species have been down-listed whereas 150 species have been added, thus the list has increased by 114. The changes are above all due to increased knowledge of taxonomy, ecology and distribution. In the present paper members of the Species Specialist Group for Fungi 2006-2010 summarize the background and results of the red-listing process and present the habitats in which the red-listed species occur.
35.	Egecioglu, Emil, 1977, et al. (författare) Growth hormone receptor deficiency results in blunted ghrelin feeding response, obesity, and hypolipidemia in mice. 2006 Ingår i: American journal of physiology. Endocrinology and metabolism. - : American Physiological Society. - 0193-1849 .- 1522-1555. ; 290:2 Tidskriftsartikel (refereegranskat)abstract We have previously shown that growth hormone (GH) overexpression in the brain increased food intake, accompanied with increased hypothalamic agouti-related protein (AgRP) expression. Ghrelin, which stimulates both appetite and GH secretion, was injected intracerebroventricularly to GHR-/- and littermate control (+/+) mice to determine whether ghrelin's acute effects on appetite are dependent on GHR signaling. GHR-/- mice were also analyzed with respect to serum levels of lipoproteins, apolipoprotein (apo)B, leptin, glucose, and insulin as well as body composition. Central injection of ghrelin into the third dorsal ventricle increased food consumption in +/+ mice, whereas no change was observed in GHR-/- mice. After ghrelin injection, AgRP mRNA expression in the hypothalamus was higher in +/+ littermates than in GHR-/- mice, indicating a possible importance of AgRP in the GHR-mediated effect of ghrelin. Compared with controls, GHR-/- mice had increased food intake, leptin levels, and total and intra-abdominal fat mass per body weight and deceased lean mass. Moreover, serum levels of triglycerides, LDL and HDL cholesterol, and apoB, as well as glucose and insulin levels were lower in the GHR-/- mice. In summary, ghrelin's acute central action to increase food intake requires functionally intact GHR signaling. Long-term GHR deficiency in mice is associated with high plasma leptin levels, obesity, and increased food intake but a marked decrease in all lipoprotein fractions.
36.	Egerhag, Helén (författare) Att främja läsutveckling i svenska som andraspråk : undervisning och tidiga insatser 2023 Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract According to The Simple View of Reading, both decoding and linguistic comprehension processes are needed for reading comprehension for L1 as well as L2 students. Previous research has shown that early support is important for students who struggle with reading. The thesis aims to investigate the role of decoding and comprehension for students learning to read in Swedish as L2 and how teaching and early special support can promote reading development. The first study in the thesis has a cross-sectional design and examines scores on decoding, vocabulary, and reading comprehension. The results showed that L2 students in grades 1-3 in Sweden had significantly weaker scores on all three tests than L1 students and that both decoding and vocabulary are related to reading comprehension. The results also showed that a significantly higher proprtion of L2 students were in need of extra support in reading. The second study is a systematic scoping review that identifies findings from reading intervention studies of L2 students. The results showed that additional small group or within-class programs can support L2 students when teaching is matched to their individual needs. The study also supported the view that instruction in skills in one language can transfer to skills in another. The third study has a between-groups design and investigates the impact of a Response to Intervention (RTI) model with a focus on decoding. The results showed that the RTI model had the potential to promote both L1 and L2 student's reading ability but to a lesser extent among L2 students. The forth study has a single subject design and examines the impact of a systematic word decoding intervention in Swedish for students learning Swedish as L2. All students improved their word decoding ability. In conclusion, it can be seen that differentiated balanced reading instruction and early support in an inclusive setting can promote reading ability in students learning Swedish as a second language. A second language perspective in early reading education is discussed.
37.	Ericson, Marten, et al. (författare) Architecture landscape 2023 Ingår i: Towards Sustainable and Trustworthy 6G: Challenges, Enablers, and Architectural Design. - 9781638282396 ; , s. 11-39 Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract The network architecture evolution journey will carry on in the years ahead, driving a large scale adoption of 5th Generation (5G) and 5G-Advanced use cases with significantly decreased deployment and operational costs, and enabling new and innovative use-case-driven solutions towards 6th Generation (6G) with higher economic and societal values. The goal of this chapter, thus, is to present the envisioned societal impact, use cases and the End-to-End (E2E) 6G architecture. The E2E 6G architecture includes summarization of the various technical enablers as well as the system and functional views of the architecture.
38.	Esguerra, John Laurence, 1991-, et al. (författare) Assessing the economic potential of landfill mining : Review and recommendations 2019 Ingår i: DETRITUS. - : CISA PUBLISHER. - 2611-4127 .- 2611-4135. ; 8, s. 125-140 Forskningsöversikt (refereegranskat)abstract As landfill mining (LFM) gains public attention, systematic assessment of its economic potential is deemed necessary. The aim of this review is to critically analyze the usefulness and validity of previous economic assessments of LFM. Following the life cycle costing (LCC) framework, (i) the employed methods based on goal and scope, technical parameters and data inventory, and modelling choices were contrasted with respect to (ii) the synthesized main findings based on net profitability and economic performance drivers. Results showed that the selected studies (n=15) are mostly case study-specific and concluded that LFM has a weak economic potential, hinting at the importance of favorable market and regulation settings. However, several method issues are apparent as costs and revenues are accounted at different levels of aggregation, scope and scale-from process to sub-process level, from private to societal economics, and from laboratory to pilot-scale, respectively. Moreover, despite the inherent large uncertainties, more than half of the studies did not perform any uncertainty or sensitivity analyses posing validity issues. Consequently, this also limits the usefulness of results as individual case studies and as a collective, towards a generic understanding of LFM economics. Irrespective of case study-specific or generic aims, this review recommends that future assessments should be learning-oriented. That is, uncovering granular information about what builds up the net profitability of LFM, to be able to systematically determine promising paths for the development of cost-efficient projects.
39.	Esguerra, John Laurence, 1991- (författare) Developing strategies for improved economic performance and reduced climate impact of landfill mining in Europe 2021 Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract Landfill mining refers to the re-circulation of resources from the previously deposited wastes. It is an alternative approach for managing landfills that integrates resource recovery with site remediation. Several resources that can be recovered in landfills include scrap metals for recycling, combustibles for energy recovery, and inert materials for construction applications. In addition, land can be recovered for alternative uses, or landfill void space can be liberated for the deposition of future wastes. At present, landfill mining is still an emerging concept with few project implementations. Consequently, the assessments of its economic and climate implications are case study-specific, limiting the understanding of its potential in a wider geographical scope. This thesis aims to assess the economic performance and climate impact of landfill mining in Europe towards the development of sound strategies for implementation. Different project setups are assessed in relation to varying factors at the site level such as waste composition and landfill settings, and at the system level such as policy and market conditions and background material and energy. In doing so, a factor-based method is developed and applied to generate multiple scenarios (531, 441 scenarios per project setup) and determine the underlying important factors and their interrelations that drive the results. Such understanding is used to develop and discuss strategies for improvement by addressing relevant questions for specific stakeholders, including project investors (i.e., which landfill sites to prioritize?), landfill mining practitioners (i.e., how to set up such projects?), and policymakers (i.e., which policy instruments can effectively support such projects?). Results show that landfill mining is preferable in terms of climate than economy. In general, about 50% of the scenarios are climate beneficial, while only about 20% of the scenarios are profitable. Possible economic and climate improvements are shown by employing internal thermal treatment of combustibles and extending fines residue utilization as construction aggregates. However, these require overarching conditions such that the choice of project setup must be in line with the selection of landfills for mining. Preferable site and system-level conditions are identified in general but it is also discussed that the plausibility of finding such conditions may be difficult at present. This steers the development of more tailored strategies on what can be done now by the landfill practitioners in terms of setting up projects under current policy and market conditions in specific regions, or what can be done by the policymakers in terms of implementing various policy instruments that can drive such changes at the system level. In this regard, the future of landfill mining research can be guided towards addressing key challenges and potential solutions for improvement elicited through a generic and learning-oriented assessment. Furthermore, this thesis highlights the role of assessment as a tool for learning and guiding the development of emerging concepts such as landfill mining.
40.	Esguerra, John Laurence, 1991- (författare) Economics of Landfill Mining : Usefulness and Validity of Different Assessment Approaches 2020 Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract Landfill mining (LFM) is an alternative strategy to manage landfills that integrates remediation with secondary resource recovery. At present, LFM remains as an emerging concept with a few pilot-scale project implementations, which presents challenges when assessing its economic performance. These challenges include large knowledge deficits about the individual processes along the LFM process chain, lack of know-how in terms of project implementation and economic drivers, and limited applicability of results to specific case studies. Based on how these challenges were addressed, this thesis aims to analyze the usefulness and validity of different economic assessments of LFM towards the provision of better support for decision-making and in-depth learning for the development of cost-efficient projects. Different studies were analyzed including the previous studies through a systematic literature review and the factor-based method that is developed in this thesis. Four categories of economic assessment approaches were derived in terms of the study object that is about either an individual LFM project (case-study specific) or multiple LFM projects in a region (generic); and in terms of the extent of analysis that is about either the identification of the net economic potential (decision-oriented) or extended towards an in-depth learning of what builds up such result (learning-oriented). Across the different approaches, most of the previous studies have questionable usefulness and validity. The unaddressed parametric uncertainties exclude the influence of using inherently uncertain input data due to large knowledge deficits. While the narrowly accounted scenario uncertainties limits the fact that LFM can be done in various ways and settings in terms of site selection, project set-up and regulatory and market conditions. In essence, these uncertainties propagate from case-study specific to generic study object. From decision-oriented to learning-oriented studies, the identification of what builds up the result are unsystematically determined that raises issues on their subsequent recommendations for improvement based on superficially derived economic drivers. The factor-based method, with exploratory scenario development and global sensitivity analysis, is presented as an approach to performing generic and learning-oriented studies. As for general recommendations, applied research is needed to aid large knowledge deficits, methodological rigor is needed to account for uncertainties and systematically identify economic drivers, and learningoriented assessment is needed to facilitate future development of LFM. This thesis highlights the important role of economic assessments, which is not only limited for the assessment of economic potential but also for learning and guiding the development of emerging concepts such as LFM.
41.	Esguerra, John Laurence, 1991-, et al. (författare) Is enhanced landfill mining profitable? 2018 Ingår i: ISWA 2018 Book of Proceedings. ; , s. 240-245 Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract The shift from linear to circular economy has steered the change in perception about landfills. From final to temporary waste storage, landfills are considered as technospheric stocks of resources that can be recovered through innovative technologies in the concept of enhanced landfill mining (ELFM). At present, most ELFM projects are in pilot-scale and it remains as a proof of concept. Economic feasibility is one of the primary considerations that must be satisfied prior to its full-scale realization. Several economic assessments were conducted in recent years but there is no systematic synthesis of these studies to date. The aim of this review is to compile various empirical insights of previous economic assessments of ELFM in relation to the employed methodological choices. With pre-defined exclusion criteria, 15 studies were selected in this review. For the empirical part, the identified main economic drivers for costs are separation and sorting, thermal treatment and transportation, while for benefits are material sales, recovered land and energy sales. In more than half of the studies, the costs exceeded the benefits concluding that ELFM is not profitable. The few potentially profitable cases mainly depend on varying the system conditions defined by market prices and regulations. These require changes that are more radical, if not impossible. For the method part, costs and benefits are accounted at different levels of aggregation, scope and scale—that is from process to sub-process level, from private to societal economics, and from laboratory to pilot scale, respectively. As most studies are based on pilot scale, if not purely conceptual, data estimation mainly depends on extrapolation from these pilot projects or on direct adoption of secondary data. In spite of the expected uncertainties in model, scenario and parameter, less than half of the studies employed sensitivity and uncertainty analyses. With it being neglected, their results can be considered to have a weak reliability for practical use in a full-scale ELFM project implementation. A need for systematic framework for early-stage assessment is highlighted to capture both stochastic and epistemic uncertainties. Process and system upscaling with exploratory scenario development, and participatory data collection in ranges rather than in absolute terms are some of the suggested approaches to generate results with a certain level of confidence. In this way, the future economic assessments of ELFM can veer away from simple profitability assessments. Instead, it focuses on knowledge development despite the limited information that is inherent to emerging concepts. Most importantly, it provides reliable information that can be used as a decision-support for various stakeholders such as project managers, technology developers, and policy makers towards the advancement of ELFM.
42.	Esguerra, John Laurence, 1991-, et al. (författare) The economic and environmental performance of a landfill mining project from the viewpoint of an industrial landfill owner 2018 Ingår i: Proceedings of the 4th International Symposium on Enhanced Landfill Mining, 5-6 February, 2018, Mechelen, Belgium. - Leuven, Belgium : University of Leuven. - 9789082825909 ; , s. 389-396 Konferensbidrag (refereegranskat)abstract The EU Commission’s circular economy strategy pushes for a higher recycling rate and a more long-term waste management practice.1 Enhanced Landfill Mining (ELFM) can contribute to this agenda as a better landfill management option, by shifting the landfill paradigm from dumping or as end-storage of waste to resource recovery or as temporary storage of resources.2-4 Through ELFM, landfills becomes a secondary source of both material (Waste-to-Material, WtM) and energy (Waste-to-Energy, WtE) with the use of innovative technologies.3,4Several studies explored the environmental and/or economic aspects of ELFM having different scopes and objectives. Some cover the entire process value chain while others additionally focused on comparing technological choices for WtE,5–7 WtM,8,9 and even ELFM waste valorisation.10 Furthermore, for the economic assessment, regulation-related costs and benefits as landfill taxes, gate fees and green certificates5,11,12 are also accounted for. Regarding the identification of economic hotspots, many of these studies concluded similar processes to be important. However, most of these studies were based on either hypothetical cases, or real cases but with small-scale excavation and separation using non-sophisticated set-ups, which are not likely to be used for large-scale processing. Hence, more uncertainty is expected from the lack of actual ELFM demonstration projects.The aim of this study is to analyse the main contributing factors that influence environmental and economic performance of ELFM, considering the landfill owner’s viewpoint. The study is based on a real case of excavation and subsequent separation in an existing stationary facility. Specifically, the influence of the prevailing system conditions is investigated as defined by the current legislation and the market situation.
43.	Esguerra, John, et al. (författare) Landfill mining in Europe : Assessing the economic potential of value creation from generated combustibles and fines residue 2021 Ingår i: Waste Management. - : PERGAMON-ELSEVIER SCIENCE LTD. - 0956-053X .- 1879-2456. ; 126, s. 221-230 Tidskriftsartikel (refereegranskat)abstract Previous studies showed that resources recovery through landfill mining (LFM) is generally challenging from an economic perspective and that a large share of project costs is related to the external treatment and disposal of bulk process wastes such as combustibles and fines residue. Building on these analyses, this study aims to explore the potential for improving the economy of LFM in Europe by creating value from these bulk process wastes. Specifically, the combustibles are treated through internal incineration with subsequent energy recovery, while fines residue is utilized as construction aggregates. These explored possibilities are investigated considering other varying factors at the site, project, and system levels that cover possible LFM project settings in Europe. A set-based modelling approach is adapted generate multiple LFM scenarios (531,441) and investigate the underlying critical factors that drive the economy of LFM through global sensitivity analysis. Results show that an additional 16% of LFM sce-narios become net profitable, mainly driven by fines residue utilization. Avoided costs for re-landfilling are higher than the revenues from construction aggregates. By contrast, internal incineration is driven by the revenues from recovered energy rather than the avoided gate fee, which is substituted by the costs for building and operating own plants. Overall, the policy conditions remain critical to further improve the economy of LFM in Europe. Recommendations include an inclusive quality standard that relies on pollutant leachability rather than total concentration for higher-value application of fines residue and incentive rather than taxation for producing renewable energy from the combustibles. (c) 2021 Elsevier Ltd. All rights reserved.
44.	Flament, Maxime, 1974, et al. (författare) On the design of an OFDM system for 60 GHZ WLAN 2001 Ingår i: Proceedings The Path to 4G Mobile, Helsinki, Finland. Konferensbidrag (refereegranskat)
45.	Flament, Maxime, 1974, et al. (författare) Performance of 60 GHz Virtual Cellular Network using Multiple Receiving Antennas 2001 Ingår i: Proc. of the 4th International Symposium on Wireless Personal Multimedia Communications 2001, Aalborg, Denmark. ; , s. 129-134 Konferensbidrag (refereegranskat)
46.	Flament, Maxime, 1974, et al. (författare) Performance of 60 GHz Virtual Cellular Networks using Multiple Receiving Antennas 2002 Ingår i: Journal on Wireless Personal Communications, Kluwer Academic Publishers. ; 23:1, s. 15-29 Tidskriftsartikel (refereegranskat)
47.	Franco Ramos, Celina, 1956, et al. (författare) The reduction in visceral fat mass in response to growth hormone is more marked in men than in oestrogen-deficient women. 2009 Ingår i: Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. - : Elsevier BV. - 1096-6374. ; 19:2, s. 112-120 Tidskriftsartikel (refereegranskat)abstract CONTEXT: Women with severe growth hormone (GH) deficiency have a less marked response to GH replacement than men. This has mostly been attributed to the attenuating effects of oestrogen replacement therapy. OBJECTIVE: To study gender related differences in the response to GH treatment in men and postmenopausal women. METHODS: Fifteen men and 15 age- and BMI-matched women with abdominal obesity (mean age: 58; range 51-64 years) were treated for one year with similar doses (0.47 vs. 0.51mg/day) of GH. All women were postmenopausal not receiving oestrogen treatment. Insulin sensitivity was assessed using a hyperinsulinemic euglycemic clamp and body composition by computed tomography (CT) scans and from total body potassium, K(40). RESULTS: Men and women were comparable at baseline in terms of waist circumference, IGF-1 and lipid levels. After one year of GH treatment, there was a 18% reduction in visceral adipose tissue (VAT) in men and a 5% reduction in women (P=0.0001 men vs. women). Although the magnitude of the difference was small, men increased more in thigh muscle mass (P<0.0001 vs. women). A reduction in thigh intermuscular adipose tissue (IMAT) and diastolic blood pressure was seen only in men (both p<0.05 vs. baseline). A decrease in LDL cholesterol, and an increase in serum insulin, was observed only in women (both p<0.05 vs. baseline). CONCLUSION: Low dose GH treatment reduced VAT more markedly in men as compared with women. As all women were postmenopausal and oestrogen-deficient, this gender difference in responsiveness was not due to an antagonistic effect of oestrogen on peripheral GH action.
48.	Franco Ramos, Celina, 1956, et al. (författare) Thigh intermuscular fat is inversely associated with spontaneous GH release in post-menopausal women with abdominal obesity. 2006 Ingår i: European journal of endocrinology / European Federation of Endocrine Societies. - : Oxford University Press (OUP). - 0804-4643. ; 155:2, s. 261-8 Tidskriftsartikel (refereegranskat)abstract CONTEXT: The metabolic syndrome is characterized by an increased accumulation of visceral adipose tissue (VAT) and blunted GH secretion. There are, however, no data on the association between GH secretion and other fat depots (in liver and muscle). OBJECTIVE/DESIGN: The aim of this cross-sectional study, which included 20 post-menopausal women with abdominal obesity, was to determine the association between GH secretion and regional adipose tissue (AT) distribution. Twelve-hour GH profiles (2000-0800 h) were performed by blood sampling every 20 min. GH was analyzed using an ultra-sensitive assay followed by approximate entropy (ApEn) and deconvolution analysis. RESULTS: In simple regression analyses, both basal and pulsatile GH secretions correlated negatively with VAT and thigh intermuscular adipose tissue (IMAT), but not with hepatic fat content. There was no correlation between ApEn and the AT depots studied. In multiple regression analysis, pulsatile GH secretion correlated inversely with thigh IMAT (B-coefficient=-0.67; P<0.01), whereas the correlation with VAT became non-significant. Furthermore, in multiple regression analysis, basal GH secretion correlated negatively with VAT (B-coefficient=-0.77; P=0.001), but not significantly with thigh IMAT. CONCLUSION: In post-menopausal women with abdominal obesity, pulsatile GH secretion demonstrated an independent, negative association with thigh IMAT, whereas basal GH secretion showed an independent, negative association with VAT. These findings suggest that the neuroendocrine association between fat mass and somatotropic axis is depot-dependent. We have identified thigh IMAT to be important in this interplay.
49.	Froberg, Gabrielle, et al. (författare) Towards clinical breakpoints for non-tuberculous mycobacteria-Determination of epidemiological cut off values for the Mycobacterium avium complex and Mycobacterium abscessus using broth microdilution 2023 Ingår i: Clinical Microbiology and Infection. - : ELSEVIER SCI LTD. - 1198-743X .- 1469-0691. ; 29:6, s. 758-764 Tidskriftsartikel (refereegranskat)abstract Objective: For non-tuberculous mycobacteria (NTM), minimum inhibitory concentration (MIC) distri-butions of wild-type isolates have not been systematically evaluated despite their importance for establishing antimicrobial susceptibility testing (AST) breakpoints.Methods: We gathered MIC distributions for drugs used against the Mycobacterium avium complex (MAC) and Mycobacterium abscessus (MAB) obtained by commercial broth microdilution (SLOMYCOI and RAPMYCOI) from 12 laboratories. Epidemiological cut-off values (ECOFFs) and tentative ECOFFs (TEC-OFFs) were determined by EUCAST methodology including quality control (QC) strains.Results: The clarithromycin ECOFF was 16 mg/L for M. avium (n = 1271) whereas TECOFFs were 8 mg/L for M. intracellulare (n = 415) and 1 mg/L for MAB (n = 1014) confirmed by analysing MAB subspecies without inducible macrolide resistance (n = 235). For amikacin, the ECOFFs were 64 mg/L for MAC and MAB. For moxifloxacin, the WT spanned >8 mg/L for both MAC and MAB. For linezolid, the ECOFF and TECOFF were 64 mg/L for M. avium and M. intracellulare, respectively. Current CLSI breakpoints for amikacin (16 mg/L), moxifloxacin (1 mg/L) and linezolid (8 mg/L) divided the corresponding WT dis-tributions. For QC M. avium and M. peregrinum, >= 95% of MIC values were well within recommended QC ranges.Conclusion: As a first step towards clinical breakpoints for NTM, (T)ECOFFs were defined for several antimicrobials against MAC and MAB. Broad wild-type MIC distributions indicate a need for further method refinement which is now under development within the EUCAST subcommittee for anti-mycobacterial drug susceptibility testing. In addition, we showed that several CLSI NTM breakpoints are not consistent in relation to the (T)ECOFFs. Gabrielle Froeuroberg, Clin Microbiol Infect 2023;29:758 (c) 2023 The Author(s). Published by Elsevier Ltd on behalf of European Society of Clinical Microbiology and Infectious Diseases. This is an open access article under the CC BY license (http://creativecommons. org/licenses/by/4.0/).
50.	Gosden, Thomas, et al. (författare) Asymmetric isolating barriers between different microclimatic environments caused by low immigrant survival. 2015 Ingår i: Royal Society of London. Proceedings B. Biological Sciences. - : The Royal Society. - 1471-2954. ; 282:1802 Tidskriftsartikel (refereegranskat)abstract Spatially variable selection has the potential to result in local adaptation unless counteracted by gene flow. Therefore, barriers to gene flow will help facilitate divergence between populations that differ in local selection pressures. We performed spatially and temporally replicated reciprocal field transplant experiments between inland and coastal habitats using males of the common blue damselfly (Enallagma cyathigerum) as our study organism. Males from coastal populations had lower local survival rates than resident males at inland sites, whereas we detected no differences between immigrant and resident males at coastal sites, suggesting asymmetric local adaptation in a source-sink system. There were no intrinsic differences in longevity between males from the different environments suggesting that the observed differences in male survival are environment-dependent and probably caused by local adaptation. Furthermore, the coastal environment was found to be warmer and drier than the inland environment, further suggesting local adaptation to microclimatic factors has lead to differential survival of resident and immigrant males. Our results suggest that low survival of immigrant males mediates isolation between closely located populations inhabiting different microclimatic environments.

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