| 1. |
- Ahlberg, Erik, et al.
(författare)
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"Vi klimatforskare stödjer Greta och skolungdomarna"
- 2019
-
Ingår i: Dagens nyheter (DN debatt). - 1101-2447.
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- DN DEBATT 15/3. Sedan industrialiseringens början har vi använt omkring fyra femtedelar av den mängd fossilt kol som får förbrännas för att vi ska klara Parisavtalet. Vi har bara en femtedel kvar och det är bråttom att kraftigt reducera utsläppen. Det har Greta Thunberg och de strejkande ungdomarna förstått. Därför stödjer vi deras krav, skriver 270 klimatforskare.
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| 2. |
- Golman, Klaes, et al.
(författare)
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13C-angiography.
- 2002
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Ingår i: Academic Radiology. - 1878-4046. ; 9:Suppl 2, s. 507-510
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Tidskriftsartikel (refereegranskat)
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| 3. |
- Holmer, Helene, et al.
(författare)
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Fracture incidence in GH-deficient patients on complete hormone replacement including GH
- 2007
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Ingår i: Journal of Bone and Mineral Research. - : Wiley. - 0884-0431 .- 1523-4681. ; 22:12, s. 1842-1850
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Tidskriftsartikel (refereegranskat)abstract
- Fracture risk in GHD patients is not definitely established. Studying fracture incidence in 832 patients on GH therapy and 2581 matched population controls, we recorded a doubled fracture risk in CO GHD women, but a significantly lower fracture risk in AO GHD men. Introduction: The objective of this study was to evaluate fracture incidence in patients wilh confirmed growth hormone deficiency (GHD) on replacement therapy (including growth hormone [GH]) compared with population controls, while also taking potential confounders and effect modifiers into account. Materials and Methods: Eight hundred thirty-two patients with GHD and 2581 matched population controls answered a questionnaire about fractures and other background information. Incidence rate ratio (IRR) and 95% CI for first fracture were estimated. The median time on GH therapy for childhood onset (CO) GHD men and women was 15 and 12 yr, respectively, and 6 and 5 yr for adult onset (AO) GHD men and women, respectively. Results: A more than doubled risk (IRR, 2.29; 95% CI, 1.23-4.28) for nonosteoporotic fractures was recorded in women with CO GHD, whereas no risk increase was observed among CO GHD men (IRR. 0.61) and AO GHD women (IRR, 1.08). A significantly decreased incidence of fractures (IRR, 0.54; 95% CI 0.34-0.86) was recorded in AO GHD men. Conclusions: Increased fracture risk in CO GHD women can most likely be explained by interaction between oral estrogen and the GH-IGF-I axis. The adequate substitution rate of testosterone (90%) and GH (94%) may have resulted in significantly lower fracture risk in AO GHD men.
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| 4. |
- Adolfsson, Per I., et al.
(författare)
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Characterization of α2-Adrenoceptor Subtypes in Pregnant Human Myometrium
- 1998
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Ingår i: Gynecologic and Obstetric Investigation. - : S. Karger AG. - 0378-7346 .- 1423-002X. ; 45:3, s. 145-150
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Tidskriftsartikel (refereegranskat)abstract
- The aim of the present investigation was to determine which subtypes of the α2-adrenoceptors are being expressed in the human pregnant myometrium at term pregnancy. In radioligand binding studies, the specific binding of [3H]rauwolscine to human myometrial membranes was specific and of high affinity with Kd of 2.8 ± 0.6 nM and Bmax of 95 ± 5 fmol/mg protein. Results from competition for the binding of [3H]rauwolscine using subtype-selective ligands, oxymetazoline (α2A-subptype), chlorpromazine (α2B-subtype) and prazosin (α2B-α2C-subtype), suggested that the α2A- and α2B-subtypes are being co-expressed. In order to examine if also the α2C-subtype is being expressed we used an optimal concentration of oxymetazoline or chlorpromazine which would block the high-affinity site, equivalent to the α2A- and α2B-subtype respectively. Competition curves of both oxymetazoline and chlorpromazine still showed a significantly better fit using a two-site model, suggesting that the α2C-subtype also is being expressed. The expression of α2C-subtype mRNA was confirmed using reverse transcription-polymerase chain reaction on mRNA isolated from myometrial biopsies.In conclusion, our results suggest that all three subtypes of α2-adrenoceptors are being coexpressed in the human myometrium at term pregnancy and that α2-expression is dominated by the α2A-subtype.
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| 5. |
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| 6. |
- Arup, Ulf, et al.
(författare)
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Lavar Lichenes
- 2015
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Ingår i: Rödlistade arter i Sverige 2015. - 9789187853104 ; , s. 72-79
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 7. |
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| 8. |
- Bergström, Göran, et al.
(författare)
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Self-report tool for identification of individuals with coronary atherosclerosis : the Swedish cardiopulmonary bioimage study
- 2024
-
Ingår i: Journal of the American Heart Association. - : John Wiley & Sons. - 2047-9980. ; 13:14
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Coronary atherosclerosis detected by imaging is a marker of elevated cardiovascular risk. However, imaging involves large resources and exposure to radiation. The aim was, therefore, to test whether nonimaging data, specifically data that can be self-reported, could be used to identify individuals with moderate to severe coronary atherosclerosis.METHODS AND RESULTS: We used data from the population-based SCAPIS (Swedish CardioPulmonary BioImage Study) in individuals with coronary computed tomography angiography (n=25 182) and coronary artery calcification score (n=28 701), aged 50 to 64 years without previous ischemic heart disease. We developed a risk prediction tool using variables that could be assessed from home (self-report tool). For comparison, we also developed a tool using variables from laboratory tests, physical examinations, and self-report (clinical tool) and evaluated both models using receiver operating characteristic curve analysis, external validation, and benchmarked against factors in the pooled cohort equation. The self-report tool (n=14 variables) and the clinical tool (n=23 variables) showed high-to-excellent discriminative ability to identify a segment involvement score ≥4 (area under the curve 0.79 and 0.80, respectively) and significantly better than the pooled cohort equation (area under the curve 0.76, P<0.001). The tools showed a larger net benefit in clinical decision-making at relevant threshold probabilities. The self-report tool identified 65% of all individuals with a segment involvement score ≥4 in the top 30% of the highest-risk individuals. Tools developed for coronary artery calcification score ≥100 performed similarly.CONCLUSIONS: We have developed a self-report tool that effectively identifies individuals with moderate to severe coronary atherosclerosis. The self-report tool may serve as prescreening tool toward a cost-effective computed tomography-based screening program for high-risk individuals.
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| 9. |
- Bergström, Göran, et al.
(författare)
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Self-Report Tool for Identification of Individuals With Coronary Atherosclerosis : The Swedish CardioPulmonary BioImage Study
-
Ingår i: Journal of the American Heart Association. - 2047-9980. ; , s. 1-13
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Coronary atherosclerosis detected by imaging is a marker of elevated cardiovascular risk. However, imaging involves large resources and exposure to radiation. The aim was, therefore, to test whether nonimaging data, specifically data that can be self-reported, could be used to identify individuals with moderate to severe coronary atherosclerosis.METHODS AND RESULTS: We used data from the population-based SCAPIS (Swedish CardioPulmonary BioImage Study) in individuals with coronary computed tomography angiography (n=25 182) and coronary artery calcification score (n=28 701), aged 50 to 64 years without previous ischemic heart disease. We developed a risk prediction tool using variables that could be assessed from home (self-report tool). For comparison, we also developed a tool using variables from laboratory tests, physical examinations, and self-report (clinical tool) and evaluated both models using receiver operating characteristic curve analysis, external validation, and benchmarked against factors in the pooled cohort equation. The self-report tool (n=14 variables) and the clinical tool (n=23 variables) showed high-to-excellent discriminative ability to identify a segment involvement score ≥4 (area under the curve 0.79 and 0.80, respectively) and significantly better than the pooled cohort equation (area under the curve 0.76, P<0.001). The tools showed a larger net benefit in clinical decision-making at relevant threshold probabilities. The self-report tool identified 65% of all individuals with a segment involvement score ≥4 in the top 30% of the highest-risk individuals. Tools developed for coronary artery calcification score ≥100 performed similarly. CONCLUSIONS: We have developed a self-report tool that effectively identifies individuals with moderate to severe coronary atherosclerosis. The self-report tool may serve as prescreening tool toward a cost-effective computed tomography-based screening program for high-risk individuals.
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| 10. |
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| 11. |
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| 12. |
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| 13. |
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| 14. |
- Eriksson, David, et al.
(författare)
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Exploring opportunities for moral disengagement in codes of conduct from the textile industry
- 2018
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Ingår i: World Review of Intermodal Transportation Research (WRITR). - 1749-4729 .- 1749-4737. ; 7:4, s. 371-389
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Tidskriftsartikel (refereegranskat)abstract
- The purpose of this research is to assess how codes of conducts are outlined and formulated in relation to moral disengagement along the supply chain. The research is focused on the idea that supply chain structure may reduce the actors' sense of moral responsibility for the actions and impacts of the supply chain on workers and environment. The research has been conducted as a case study including Swedish firms in the textile industry. The research has used secondary data from codes of conducts. The findings show that codes of conduct do not cover all supply chain practices linked with moral disengagement. This does not cause immoral behaviour as such, but might cause moral disengagement. Supply chain research needs to focus on what should be included in codes of conduct and other ethical guidelines, so as to reduce the risk of immoral behaviour. In order to reduce the likelihood for moral disengagement, there are several supply chain practices that should be included in codes of conduct, such as power asymmetry, managerial support, and incentives.
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| 15. |
- Eriksson, David, et al.
(författare)
-
Exploring opportunities for moral disengagement in codes of conduct from the textile industry
- 2018
-
Ingår i: World Review of Intermodal Transportation Research (WRITR). - : InderScience Publishers. - 1749-4729 .- 1749-4737. ; 7:4, s. 371-389
-
Tidskriftsartikel (refereegranskat)abstract
- The purpose of this research is to assess how codes of conducts are outlined and formulated in relation to moral disengagement along the supply chain. The research is focused on the idea that supply chain structure may reduce the actors' sense of moral responsibility for the actions and impacts of the supply chain on workers and environment. The research has been conducted as a case study including Swedish firms in the textile industry. The research has used secondary data from codes of conducts. The findings show that codes of conduct do not cover all supply chain practices linked with moral disengagement. This does not cause immoral behaviour as such, but might cause moral disengagement. Supply chain research needs to focus on what should be included in codes of conduct and other ethical guidelines, so as to reduce the risk of immoral behaviour. In order to reduce the likelihood for moral disengagement, there are several supply chain practices that should be included in codes of conduct, such as power asymmetry, managerial support, and incentives.
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| 16. |
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| 17. |
- Eriksson, Lars, et al.
(författare)
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On Visual, Vibrotactile, and 3D Audio Directional Cues for Dismounted Soldier Waypoint Navigation
- 2008
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Ingår i: PROCEEDINGS of the HUMAN FACTORS AND ERGONOMICS SOCIETY 52nd ANNUAL MEETING—2008. - Los Angeles : Sage Publications. - 2169-5067 .- 1071-1813. ; , s. 1282-1286
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Konferensbidrag (refereegranskat)abstract
- We compared a visual GPS, a tactile torso belt, and a 3D audio display in a waypoint navigation task for dismounted soldiers. Using these displays one at a time, the soldier’s main tasks were to walk as fast and straight as possible towards the waypoints while visually scanning the terrain for detection of target flags. The results showed that all three types of displays gave similar navigation precision and target detection performance. The visual display entailed a somewhat higher navigation speed than the tactile and 3D audio displays. Both the visual and 3D audio displays, however, were rated as directing attention away from the terrain more than the tactile display. Compared to the tactile display, a higher mental workload was reported for the 3D audio, which was also rated least suitable for operational use in navigation tasks. Yet, the soldiers’ ability to localize directions to waypoints with the 3D audio display may point to its potential use for radio communication and cueing of directions to threats. In an overall evaluation, eight soldiers preferred the tactile display and four the visual, while none preferred the 3D audio. We discuss the results mainly regarding shortcomings of the study and the possibility of developing and combining the three display types for the dismounted soldier.
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| 18. |
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| 19. |
- Fransson, Göran, 1968-, et al.
(författare)
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On the Swedish National Grade School for Digital Technologies in Education – GRADE : Expectations and experiences of doctorial students and supervisors
- 2018
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Ingår i: ICERI2018 Proceedings. - Sevilla : IATED. - 9788409059485 ; , s. 769-774
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Konferensbidrag (refereegranskat)abstract
- The Swedish National Graduate School for Digital Technologies in Education (GRADE) is a cooperative venture between six Swedish universities established during 2018. Within the field of educational sciences and in the area of digital technologies in education, GRADE aims to strengthen the expertise in the area and to increase national and international cooperation in research training activities.Over a number of years, and from multitude of sources (cf. Brown & Davis, 2004; Fisher, Higgins & Loveless, 2006; Kafai & Resnick 1996), research has stressed that increased digitalization in schools leads to a complexity that needs to be taken into account on different levels, from different perspectives and with different designs, methodologies and theoretical perspectives (cf. Olofsson, Lindberg, Fransson & Hauge, 2015; Price, Jewitt & Brown, 2013; Tondeur, Valcke & van Braak, 2008). At a micro-level, the learning situation of students, teachers and school-leaders changes and it becomes important to deepen the knowledge about the impact digital technologies has on the fundamental conditions for teaching and learning of different school subjects (cf. Chun, Kern & Smith 2016; Leung & Baccaglini-Frank, 2017). On a macro-level, conditions for education as such changes and digital technologies becomes an important object of study as agents of change (Wong & Li, 2008). The digitalization of K-12 schools has long been highlighted in policy as a necessity (cf. Kirkman et al, 2002; OECD, 2010). However, research and evaluations (cf. Fransson et al, 2012; OECD, 2015; Wastiau et al, 2013) show that many substantial challenges remain. One of the fundamental pillars of GRADE is the interdisciplinary approach. Several disciplines are present (Applied IT, Curriculum studies, Education, Informatics, Technology and Learning, Educational work, Work-interated Learning) in researching digital technologies in K-12 schools with the ambition to contribute to the continued implementation, integration and use of digital technologies in Swedish K-12 schools that stems from the evidence-based knowledge produced within the activities of GRADE. The research within GRADE will be characterized by close cooperation with stakeholders from school practice, with the aim to contribute to concrete school development. In GRADE, a multi-level approach that involves multiple layers or levels of school activities will be encouraged. When possible, studies will be longitudinal. This will imply studies from an organizational and management perspective, e.g. studies of school leaders and other members of senior management positions responsible for digital technology use and implementation. Also implied are studies of teachers' teaching practices and didactical considerations, as well as studies of the students in classrooms and their learning using digital technologies. This will also imply that several issues with a bearing on the digitalization of education, for example regarding school policy, teaching, learning, assessment and professional development will be researched from different perspectives and with different methodological approaches. In this paper, these points of departure will be explored based on the expectations and experiences of the first twelve admitted doctoral students and their supervisors.
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| 20. |
- Gedda, Magnus, 1978-, et al.
(författare)
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Image Processing System for Localising Macromolecules in Cryo-Electron Tomography
-
Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- A major challenge in today's molecular biology research is to understand the interaction between proteins at the molecular level. Cryo-electron tomography (ET) has come to play an important role in facilitating objective qualitative experiments on protein structures and their interaction. Various protein conformation structures can be qualitatively analysed as complete galleries of proteins are captured by ET. To facilitate fast and objective macromolecular structure analysis procedures, image processing has become a crucial tool. This paper presents an image processing system for localising individual proteins from in vitro samples imaged by ET. We have evaluated the system using simulated data as well as experimental data.
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| 21. |
- German, Jonas, 1972, et al.
(författare)
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Modelling of different measures for improving removal in a stormwater pond
- 2004
-
Ingår i: Proceedings of the 6th international conference on Urban Drainage Modelling. ; , s. 477-484
-
Konferensbidrag (refereegranskat)abstract
- The effect on removal efficiency and hydraulic performance of retrofitting an existing pond was modelled using the commercial software Mike21 and compartmental modelling. The Mike21 model had previously been calibrated on the studied pond. Installation of baffles, the addition of culverts under a causeway and removal of an existing island were all studied as possible improvement measures in the pond. The subsequent effect on hydraulic performance and removal of suspended solids was then evaluated. Copper, cadmium, BOD, nitrogen and phosphorous removal were also investigated for the improvement measure showing the best results. Outcomes of this study reveal that all measures increase the removal efficiency of suspended solids. The hydraulic efficiency is improved for all cases, except for the case where the island is removed. Compartmental modelling was also used to evaluate hydraulic performance and facilitated a better understanding of the way each of the different measures affected the flow pattern and performance. It was concluded that the installation of baffles is the best of the studied measures resulting in a reduction in the annual load on the receiving lake by approximately 8,000 kg of suspended solids, 2 kg of copper and 600 kg of BOD.
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| 22. |
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| 23. |
- Hammarström, Lars G. J., et al.
(författare)
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The Oncolytic Efficacy and in Vivo Pharmacokinetics of [2-(4-Chlorophenyl)quinolin-4-yl](piperidine-2-yl)methanol (Vacquinol-1) Are Governed by Distinct Stereochemical Features
- 2016
-
Ingår i: Journal of Medicinal Chemistry. - : American Chemical Society (ACS). - 0022-2623 .- 1520-4804. ; 59:18, s. 8577-8592
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Tidskriftsartikel (refereegranskat)abstract
- Glioblastoma remains an incurable brain cancer. Drugs developed in the past 20 years have not improved the prognosis for patients, necessitating the development of new treatments. We have previously reported the therapeutic potential of the quinoline methanol Vacquinol-1 (1) that targets glioblastoma cells and induces cell death by catastrophic vacuolization. Compound 1 is a mixture of four stereoisomers due to the two adjacent stereogenic centers in the molecule, complicating further development in the preclinical setting. This work describes the isolation and characterization of the individual isomers of 1 and shows that these display stereospecific pharmacokinetic and pharmacodynamic features. In addition, we present a stereoselective synthesis of the active isomers, providing a basis for further development of this compound series into a novel experimental therapeutic for glioblastoma.
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| 24. |
- Hansson, Klas, et al.
(författare)
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Utvärdering av djupdränering och effekt av tätad stödremsa och innerslänt utmed väg 126, Torpsbruk
- 2012
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Djupdränering är en effektiv metod för att reglera grundvattenytan och kan, i samband med väggbygge, rekommenderas som metod i de fall vägen ligger i jordskärning under befintlig markyta i kombination med hög grundvattenyta. Dräneringen måste dock underhållas för att behålla sin effektivitet.Utmed väg 126 nära Torpsbruk har Trafikverket under många år haft problem med bärighet, tjälskott och liknande. Problemen bedöms bero på en kombination av dåliga material och för höga vattenhalter på den aktuella platsen.Försök som VTI gjort på platsen visar att djupdränering är en mycket effektiv metod att reglera grundvattenytan. Detta kunde bekräftas vid dämningsförsöken då grundvattennivåerna steg och sjönk mycket snabbt i samband med pluggning och öppning av djupdräneringen. Djupdränering är även en mycket effektiv metod att reglera vattenhalten i vägen, i synnerhet då grundvattenytan utan djupdränering ligger högt i vägkonstruktionen. Tätning av stödremsa och innerslänt påverkade vattenhaltens dynamik. För att undersöka infiltrationen av regn och vägvatten tätades även en del av stödremsan och innerslänten längs vägen.Resultaten kan användas för att utvärdera om täta innerslänter kan vara lämpligt ur underhållssynpunkt av vägar. För att kunna utvärdera den långsiktiga effekten av en tätad stödremsa och innerslänt på vattenhalterna i vägen måste mätningar pågå under ett eller ett par år till.
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| 25. |
- Ihse, Ingemar, et al.
(författare)
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Riktlinjer för handläggning av patienter med pankreascancer
- 2002
-
Ingår i: Läkartidningen. - 0023-7205. ; 99:15, s. 1676-1683
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Tidskriftsartikel (refereegranskat)abstract
- The incidence of pancreatic cancer has fallen during the last ten years in Sweden. Early signs and symptoms of the disease are still undiscovered and when diagnosis is made the disease is incurable in most patients. Transabdominal ultrasonography is the first-line imaging test followed by spiral computed tomography (CT) and magnetic resonance imaging (MRI) if required for definite diagnosis. Spiral CT is also the imaging test of choice for assessment of resectability of the tumor. Surgical removal of the tumor is the only chance of cure. Markedly improved hospital mortality after pancreaticoduodenectomy is reported and an association between hospital volume and outcome of the operation has been established. Longterm survival after attempted curative resection continues to be dismal, however. Adjuvant treatment should not be given outside clinical studies. Palliative treatment has improved thanks to progress in the field of endoscopy, interventional radiology and in management of pain and nutrition. Palliative chemotherapy should only be given selectively outside clinical studies. Radiotherapy has no proven effects on survival. Special pancreatic cancer treatment teams with catchment areas of 2-4 million inhabitants are recommended by international authorities.
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| 26. |
- Ihse, Ingemar, et al.
(författare)
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Riktlinjer för handläggning av patienter med pankreascancer [Guidelines for management of patients with pancreatic cancer]
- 2002
-
Ingår i: Läkartidningen. - 0023-7205 .- 1652-7518. ; 99:15, s. 1676-1685
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Transabdominellt ultraljud är förstahandsundersökning vid misstänkt pankreascancer, följt av spiral-DT eller MR för mer definitiv diagnos. Tumörmarkörer har ingen plats i rutindiagnostiken. Spiral-DT är basen i resektabilitetsbedömningen. Resektion av tumören är en förutsättning för bot. Ett samband har påvisats mellan antalet resektioner som görs vid ett sjukhus årligen och postoperativ mortalitet. Långtidsöverlevnaden efter resektion är oförändrat kort medan postoperativ mortalitet minskat dramatiskt vid enheter som rapporterat sina resultat. Adjuvant behandling efter resektion bör endast ges inom ramen för kliniska studier. Det palliativa omhändertagandet har förbättrats främst genom utveckling inom endoskopi, interventionell radiologi, smärt- och nutritionsbehandling. Palliativ cytostatikabehandling bör endast ges selektivt utanför kliniska studier. Radioterapi har ingen dokumenterad effekt på överlevnaden vid icke-resektabel pankreascancer. Internationellt rekommenderas speciella behandlingsteam för pankreascancer med tillräckliga upptagningsområden (2–4 miljoner invånare).
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| 27. |
- Isern, A E, et al.
(författare)
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Grisel syndrome after velopharyngoplasty
- 2004
-
Ingår i: Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery. - : Informa UK Limited. - 1651-2073 .- 0284-4311. ; 38:1, s. 53-57
-
Tidskriftsartikel (refereegranskat)abstract
- We describe two patients with Grisel syndrome (atlantoaxial dislocation) after velopharyngoplasty. One required open fixation, while the other was treated with closed reduction and skull traction. Both patients recovered well after long-term follow-up. Early detection and appropiate treatment improve the prognosis.
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| 28. |
- Lagerstrand, Kerstin M, et al.
(författare)
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Reliable phase-contrast flow volume magnetic resonance measurements are feasible without adjustment of the velocity encoding parameter
- 2020
-
Ingår i: Journal of Medical Imaging. - 2329-4310 .- 2329-4302. ; 7:6
-
Tidskriftsartikel (refereegranskat)abstract
- Purpose: To show that adjustment of velocity encoding (VENC) for phase-contrast (PC) flow volume measurements is not necessary in modern MR scanners with effective background velocity offset corrections. Approach: The independence on VENC was demonstrated theoretically, but also experimentally on dedicated phantoms and on patients with chronic aortic regurgitation (n = 17) and one healthy volunteer. All PC measurements were performed using a modern MR scanner, where the pre-emphasis circuit but also a subsequent post-processing filter were used for effective correction of background velocity offset errors. Results: The VENC level strongly affected the velocity noise level in the PC images and, hence, the estimated peak flow velocity. However, neither the regurgitant blood flow volume nor the mean flow velocity displayed any clinically relevant dependency on the VENC level. Also, the background velocity offset was shown to be close to zero (
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| 29. |
- Lindahl, Göran, et al.
(författare)
-
Centrala Jönköping : Den Nordiska Trästaden
- 1972
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Rapport (populärvet., debatt m.m.)abstract
- Konsthögskolans Arkitektur skola har under studieåret 1971-72 behandlat förnyelseproblemen i centrala Jönköping. Huvudvikten har lagts vid de problem som uppstått vid över gången från 60-talets överhettade konjunktur till 70-talets mera dämpade. I denna situation framstår det som naturligt att begränsa eller hejda den omdaningsprocess i Jönköpings centrala delar, som i så hög grad varit ett uttryck för de expansiva årens förväntningar. Denna typ av restriktiv planering förutsätter en mycket detaljerad kunskap om den befintliga bebyggelsen och dess utnyttjande. Föreliggande arbete bygger således på inventeringar, genomförda på platsen, och på tillgängligt utredningsmaterial som förmedlats av kommunens tjänstemän. Studierna har koncentrerats till två områden i staden, som representerar var sitt skede i Jönköpings byggnadshistoria, och som också bedömts möjliga att bevara.
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| 30. |
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| 31. |
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| 32. |
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| 33. |
- Risacher, C., et al.
(författare)
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A 279-381 GHz SIS Receiver for the APEX Telescope
- 2006
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Ingår i: Proceedings of the 16th International Symposium on Space Terahertz Technology, Chalmers University of Technology, Gothenburg, Sweden, May 2-4, 2005. ; , s. 432-437
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 34. |
- Sidebäck, Göran, et al.
(författare)
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Projektarbete i lokala samverkansgrupper : Dokumentation från et utvärderingscirkel för projektledare och projektmedarbetare i lokala samverkansprojekt
- 2002
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Under 2001 deltog ett antal tjänstemän, som arbetar med lokala samverkansprojekt i Södermanlands län, i en cirkel som anordnades av Centrum för välfärdsforskning vid Mälardalens högskola. Syftet var att de skulle få stöd och handledning i sina pågående projektarbeten, genom att projekten togs upp till gemensam diskussion och granskning vid cirkelsammankomsterna, där också forskare från högskolan medverkade. I denna rapport, som bygger på cirkeldeltagarnas och cirkelledarnas gemensamma arbete, redovisas hur cirkelarbetet organiserats och genomförts, samt hur cirkeldeltagarna själva värderar utbytet av sitt deltagande. Cirkeln kan ses som ett försök att utveckla nya former för samarbete mellan högskolan och regionen på kompetensutvecklingsområdet. Rapporten kan därmed vara ett underlag i en fortstatt diskussion om hur samverkan mellan regionen och högskolan kan förbättras och utvecklas på detta område.
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| 35. |
- Svedhem, Sofia, et al.
(författare)
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Subtle differences in dissociation rates of interactions between destabilized human carbonic anhydrase II mutants and immobilized benzenesulfonamide inhibitors probed by a surface plasmon resonance biosensor
- 2001
-
Ingår i: Analytical Biochemistry. - : Elsevier BV. - 0003-2697 .- 1096-0309. ; 296:2, s. 188-196
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Tidskriftsartikel (refereegranskat)abstract
- The development of commercial biosensors based on surface plasmon resonance has made possible careful characterization of biomolecular interactions. Here, a set of destabilized human carbonic anhydrase II (HCA II) mutants was investigated with respect to their interaction kinetics with two different immobilized benzenesulfonamide inhibitors. Point mutations were located distantly from the active site, and the destabilization energies were up to 23 kJ/mol. The dissociation rate of wild-type HCA II, as determined from the binding to the inhibitor with higher affinity, was 0.019 s−1. For the mutants, dissociation rates were faster (0.022–0.025 s−1), and a correlation between faster dissociation and a high degree of destabilization was observed. We interpreted these results in terms of increased dynamics of the tertiary structures of the mutants. This interpretation was supported by entropy determinations, showing that the entropy of the native structure significantly increased upon destabilization of the protein molecule. Our findings demonstrate the applicability of modern biosensor technology in the study of subtle details in molecular interaction mechanisms, such as the long-range effect of point mutations on interaction kinetics.
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| 36. |
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| 37. |
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| 38. |
- Svensson, Lars-Håkan, et al.
(författare)
-
Lasse Söderberg
- 2017
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Ingår i: En lundensisk litteraturhistoria. - 9789170612503 ; , s. 335-337
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Bokkapitel (populärvet., debatt m.m.)
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| 39. |
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| 40. |
- Svensson, Stina, et al.
(författare)
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Using a fuzzy framework for delineation and decomposition of immunoglobulin G in cryo electron tomographic images
- 2006
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Ingår i: Proceedings The 18th International Conference on Pattern Recognition (ICPR 2006). - 0769525210 ; , s. 961-
-
Konferensbidrag (refereegranskat)abstract
- In structural studies of proteins, the first task is to identify the different parts of the protein. We present a robust method using a fuzzy framework for delineating a protein and to identify its parts. The method is used in a study of the immunoglobulin G antibody, individually imaged using cryo electron tomography, with satisfactory results.
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| 41. |
- Vikström, Maria, et al.
(författare)
-
Dagvattendammars avskiljningsförmåga – påverkande faktorer och metodik för bedömning
- 2004
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Rapporten beskriver hur numeriska modeller, främst MIKE 21, använts för att ta fram en generell beräkningsmetodik för bedömning av dagvattendammars avskiljningsförmåga. En modellbaserad fallstudie har genomförts för att studera de påverkansfaktorer som styr avskiljningen i en dagvattendamm.
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| 42. |
- Öhrström, Lars, 1963, et al.
(författare)
-
On the structures and properties of Cr(DMSO)(6)(3+) and the coordination polymer cis-Cr(III)(oxalate)(2)(DMSO)(2) K(DMSO)(2) (n)
- 2000
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Ingår i: Inorganica Chimica Acta. ; 305:2, s. 157-162
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Tidskriftsartikel (refereegranskat)abstract
- cis-Cr(III)(oxalate)(2)(DMSO)(2)K(DMSO)(2) was formed by K3Cr(oxalate), in dimethylsulfoxide-THF mixtures. The structure is ribbon-like with cis-Cr(oxalate)(2)(DMSO)(2)(-) complex ions bridged by oxalates to (DMSO)K(DMSO)(2)K(DMSO) units forming interconnected rings of six metal complexes. In the same type of solutions Cr(DMSO)(6)(NO3)(3) was also formed. In this structure Cr(III) is six-coordinated by oxygens from DMSO. Cr(DMSO)(6)(NO3)(3) is isostructural with Fe(DMSO)(6)(NO3)(3) (J.R. Tzou et al., Acta Crystallogr., Sect. C, 51 (1995) 2249). The Cr(III)-O distance shows an expected shortening of about 0.04 Angstrom compared to the Fe(III)-O bond in Fe(DMSO)(6)(NO3)(3). (C) 2000 Elsevier Science S.A. All rights reserved.
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| 43. |
- Öhrström, Lars, 1963, et al.
(författare)
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The pedagogical implications of using MatLab in integrated chemistry and matehamatics courses
- 2005
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Ingår i: International journal of engineering education. - 0949-149X. ; 21:4, s. 683-691
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Tidskriftsartikel (refereegranskat)abstract
- The last years the undergraduate chemistry and mathematics courses at Chalmers Tekniska Högskola (Chalmers University of Technology, Sweden) has undergone a major curriculum reform. One of the driving motives behind the reform was that students should learn to use mathematics as a real tool for solving chemical problems. Mathematicians and chemists, with pedagogical help from an educational expert, changed the traditional course structure in terms of organisation, content, and teaching and learning methods. This paper concentrates on the use of MATLAB in laboratory work and in individual and group assignments. It deals, in particular, with the pedagogical benefits that the designers of the new course saw in presenting real chemical problems that could be solved using applied mathematics and the MATLAB software. Student experience was evaluated both by the teachers and the educational consultant and responses are largely positive. Increased student learning can be seen through higher motivation and synergy effects of treating chemical problems in the MATLAB tutorials. The most serious problem is to give all students the necessary MATLAB skills and a risk is an overestimation of the MATLAB proficiency in subsequent courses leading to un-proportional workload on projects and little time for reading and study.
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