| 1. |
- Svensson, Carl-Johan, 1977-, et al.
(författare)
-
Diverseannonser i Dagens Nyheters historia
- 2012
-
Ingår i: Presshistorisk årsbok 2012. - Stockholm : Svensk Presshistorisk Förening. ; , s. 29-50
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
- Almén, Oscar, 1970-, et al.
(författare)
-
Kina idag
- 2008
-
Bok (populärvet., debatt m.m.)
|
|
| 5. |
- Andersson, Märta, et al.
(författare)
-
Mycobacterium bovis bacilli Calmette-Guerin regulates leukocyte recruitment by modulating alveolar inflammatory responses.
- 2012
-
Ingår i: Innate Immunity. - : SAGE Publications. - 1753-4267 .- 1753-4259. ; 18, s. 531-540
-
Tidskriftsartikel (refereegranskat)abstract
- Leukocyte migration into the epithelial compartment is an important feature in the active phase of mycobacterial infections. In this study, we used the Transwell model to investigate the mechanisms behind mycobacteria-induced leukocyte recruitment and investigated the role of TLR2 and TLR4 in this process. Infection of epithelial cells resulted in significantly increased secretion of the neutrophil chemotactic CXCL8 and IL-6, but no secretion of monocyte chemotactic CCL2 or TNF-α was observed. In contrast to epithelial response, mycobacteria-infected neutrophils and monocytes secreted all these cytokines. Corresponding with epithelial cytokine response, mycobacterial infection of the epithelial cells increased neutrophil diapedesis, but decreased monocyte recruitment. However, monocyte recruitment towards mycobacteria infected epithelial cells significantly increased following addition of neutrophil pre-conditioned medium. Mycobacterial infection also increases alveolar epithelial expression of TLR2, but not TLR4, as analyzed by flow cytometry, Western blotting and visualized by confocal microscopy. Blocking of TLR2 inhibited neutrophil recruitment and cytokine secretion, while blocking of TLR4 had a lesser effect. To summarize, we found that primary alveolar epithelial cells produced a selective TLR2-dependent cytokine secretion upon mycobacterial infection. Furthermore, we found that cooperation between cells of the innate immunity is required in mounting proper antimicrobial defence.
|
|
| 6. |
- Andersson, Oscar
(författare)
-
Process planning of resistance spot welding
- 2013
-
Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Manufacturing engineering in general has experienced an increased demand of process planning in order to optimize processes to reduce costs, environmental impact and increase time efficiency. Resistance spot welding (RSW) is a common and large-scale joining method in several manufacturing industries indicating significant potentials of efficient process planning.The goal of this thesis is to establish new knowledge for updated and improved process planning of RSW in industrial applications. The goal is expressed by two research questions targeting the issues of process variations and potential of numerical methods of the RSW process. The research questions are expressed in terms of weld size, which is the main interest in RSW process planning.As any large-scale manufacturing process, RSW involves variations in results – the weld size is known to vary, both as a result of intentional dependent parameters such as process parameters and as a result of unintentional variations in welding conditions. A series of physical and numerical analysis have been performed in order to gain knowledge of such variations.The unintentional variations, which result in varying weld sizes in apparently identical conditions, were analyzed through both controlled laboratory welding and welding in industrial production environments. The results of the analysis showed the magnitude of standard deviations in both environments and the distribution of weld sizes. The analysis showed that common standard deviations in controlled laboratories and industrial production are approximately 0.3 mm and 0.9 mm, respectively and that weld sizes are distributed showed promising fit to both Normal and Weibull distributions.The intentional variations of weld sizes due to process parameters, which is the most important aspect of RSW process planning, have traditionally been analyzed through physical testing. In the present thesis two numerical methods were evaluated; regression analysis and FE simulations. For the regression analysis several models were generated and showed a standard deviation of residuals between model and physical results of 0.5 mm. For the FE simulations, material models for the RSW were generated and the simulations showed a standard deviation compared to physical testing of 0.68 mm. In conclusion, the present thesis presents results, which help quantify variations in weld sizes and present the capability of numerical methods of the RSW process.
|
|
| 7. |
- Berggren, Magnus, et al.
(författare)
-
PEDOT : PSS-Based Electrochemical Transistors for Ion-to-Electron Transduction and Sensor Signal Amplification
- 2008. - 1
-
Ingår i: Organic Semiconductors in Sensor Applications. - Berlin, Heidelberg : Springer. - 9783540763147 - 9783540763130 - 9783642095177 ; , s. 263-280
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- The chapter reports the use of organic electrochemical transistors in sensor applications. These transistors are excellent ion-to-electron transducers and can serve as very sensitive transducers in amperometric sensor applications. To further improve their sensitivity, we outline various amplification circuits all realized in organic electrochemical transistors.
|
|
| 8. |
|
|
| 9. |
- Borg, Markus, et al.
(författare)
-
SZZ unleashed: an open implementation of the SZZ algorithm : featuring example usage in a study of just-in-time bug prediction for the Jenkins project
- 2019
-
Konferensbidrag (refereegranskat)abstract
- Machine learning applications in software engineering often rely on detailed information about bugs. While issue trackers often contain information about when bugs were fixed, details about when they were introduced to the system are often absent. As a remedy, researchers often rely on the SZZ algorithm as a heuristic approach to identify bug-introducing software changes. Unfortunately, as reported in a recent systematic literature review, few researchers have made their SZZ implementations publicly available. Consequently, there is a risk that research effort is wasted as new projects based on SZZ output need to initially reimplement the approach. Furthermore, there is a risk that newly developed (closed source) SZZ implementations have not been properly tested, thus conducting research based on their output might introduce threats to validity. We present SZZ Unleashed, an open implementation of the SZZ algorithm for git repositories. This paper describes our implementation along with a usage example for the Jenkins project, and conclude with an illustrative study on just-in-time bug prediction. We hope to continue evolving SZZ Unleashed on GitHub, and warmly invite the community to contribute.
|
|
| 10. |
- Braun, Oscar, et al.
(författare)
-
Concomitant use of warfarin and ticagrelor as an alternative to triple antithrombotic therapy after an acute coronary syndrome.
- 2015
-
Ingår i: Thrombosis Research. - : Elsevier BV. - 1879-2472 .- 0049-3848. ; 135:1, s. 26-30
-
Tidskriftsartikel (refereegranskat)abstract
- Treatment with warfarin in combination with clopidogrel has been shown to reduce the incidence of major bleeding as compared to triple antithrombotic therapy (TT; warfarin, clopidogrel and aspirin). However, there are uncertainties regarding the risk for thrombosis since poor-responsiveness to clopidogrel is common. Ticagrelor is a more potent platelet inhibitor, but data supporting concurrent use of ticagrelor and warfarin (dual antithrombotic therapy, DT) is limited. This study therefore sought to evaluate the risk of bleeding and thrombosis associated with DT after an acute coronary syndrome (ACS).
|
|
| 11. |
- Brehm, Stefan, et al.
(författare)
-
Are Model Cities an Effective Instrument for Urban Environmental Governance?
- 2019
-
Ingår i: Greening China's Urban Governance : Tackling Environmental and Sustainability Challenges - Tackling Environmental and Sustainability Challenges. - Singapore : Springer Nature Singapore. - 2367-1068 .- 2367-105X. - 9789811307393 - 9789811307409 ; 7, s. 25-49
-
Bokkapitel (refereegranskat)abstract
- Since the 1980s, China’s central government has created various model and incentive schemes aimed at systematically and concurrently promoting innovative approaches for protecting the urban ecological environment. In this context, programmes such as the ‘model city for protecting the environment’, ‘garden city’, ‘eco-city’, or ‘low-carbon city’ have become an integral part of China’s system for urban environmental governance. However, the role of these policy-incentive schemes for promoting best practice is only partly understood. This chapter contributes to the literature with a conceptualization of model cities as a dynamic governance instrument. The analysis suggests that the distance between programme objectives and local practices increases with programme maturity. Model-city schemes inevitably reach a point of saturation once a competing programme provides new opportunities to gain political and economic rents.
|
|
| 12. |
- Elf, Anna-Karin, et al.
(författare)
-
Radioembolization Versus Bland Embolization for Hepatic Metastases from Small Intestinal Neuroendocrine Tumors: Short-Term Results of a Randomized Clinical Trial.
- 2018
-
Ingår i: World Journal of Surgery. - : Springer Science and Business Media LLC. - 0364-2313 .- 1432-2323. ; 42:2, s. 506-513
-
Tidskriftsartikel (refereegranskat)abstract
- Radioembolization (RE) with intra-arterial administration of 90Y microspheres is a promising technique for the treatment of liver metastases from small intestinal neuroendocrine tumors (SI-NET) not amenable to surgery or local ablation. However, studies comparing RE to other loco-regional therapies are lacking. The aim of this randomized study was to compare the therapeutic response and safety after RE and bland hepatic arterial embolization (HAE), and to investigate early therapy-induced changes with diffusion-weighted MRI (DWI-MRI).Eleven patients were included in a prospective randomized controlled pilot study, six assigned to RE and five to HAE. Response according to RECIST 1.1 using MRI or CT at 3 and 6months post-treatment was recorded as well as changes in DWI-MRI parameters after 1month. Data on biochemical tumor response, toxicity, and side effects were also collected.Three months after treatment, all patients in the HAE group showed partial response according to RECIST while none in the RE group did (p=0.0022). After 6months, the response rates were 4/5 (80%) and 2/6 (33%) in the HAE and RE groups, respectively (NS). DWI-MRI metrics could not predict RECIST response, but lower pretreatment ADC(120-800) and larger ADC(0-800) increase at 1month were related to larger decrease in tumor diameter when all tumors were counted.HAE resulted in significantly higher RECIST response after 3months, but no difference compared to RE remained after 6months. These preliminary findings indicate that HAE remains a safe option for the treatment of liver metastases from SI-NET, and further studies are needed to establish the role of RE and the predictive value of MR-DWI.
|
|
| 13. |
- Ellingsen, Tore, et al.
(författare)
-
Anchoring and Cognitive Ability
- 2010
-
Ingår i: Economics Letters. - : Elsevier. - 0165-1765. ; 107:1, s. 66-68
-
Tidskriftsartikel (refereegranskat)
|
|
| 14. |
|
|
| 15. |
- Eriksson, Victoria, et al.
(författare)
-
A retrospective analysis of the de ritis ratio in muscle invasive bladder cancer, with focus on tumor response and long-term survival in patients receiving neoadjuvant chemotherapy and in chemo naïve cystectomy patients : a study of a clinical multicentre database
- 2022
-
Ingår i: Journal of Personalized Medicine. - : MDPI. - 2075-4426. ; 12:11
-
Tidskriftsartikel (refereegranskat)abstract
- Background: A high pre-treatment De Ritis ratio, the aspartate transaminase/alanine aminotransferase ratio, has been suggested to be of prognostic value for mortality in muscle-invasive bladder cancer (MIBC). Our purpose was to evaluate if a high ratio was associated with mortality and downstaging. Methods: A total of 347 Swedish patients with clinically staged T2-T4aN0M0, with administered neoadjuvant chemotherapy (NAC) or eligible for NAC and undergoing radical cystectomy (RC) 2009–2021, were retrospectively evaluated with a low ratio < 1.3 vs. high ratio > 1.3, by Log Rank test, Cox regression and Mann–Whitney U-test (MWU), SPSS 27. Results: Patients with a high ratio had a decrease of up to 3 years in disease-free survival (DFS), cancer-specific survival (CSS) and overall survival (OS) (p = 0.009, p = 0.004 and p = 0.009) and 5 years in CSS and OS (p = 0.019 and p = 0.046). A high ratio was associated with increased risk of mortality, highest in DFS (HR, 1.909; 95% CI, 1.265–2.880; p = 0.002). No significant relationship between downstaging and a high ratio existed (p = 0.564 MWU). Conclusion: A high pre-treatment De Ritis ratio is on a population level, associated with increased mortality post-RC in endpoints DFS, CSS and OS. Associations decrease over time and require further investigations to determine how strong the associations are as meaningful prognostic markers for long-term mortality in MIBC. The ratio is not suitable for downstaging-prediction.
|
|
| 16. |
- Fahlström, Karl, 1986-, et al.
(författare)
-
Correlation between laser welding sequence and distortions for thin sheet structures
- 2017
-
Ingår i: Science and technology of welding and joining. - : Informa UK Limited. - 1362-1718 .- 1743-2936. ; 22:2, s. 150-156
-
Tidskriftsartikel (refereegranskat)abstract
- Thin ultra-high strength steel shaped as 700 mm long U-beams have been laser welded in overlap configuration to study the influence of welding sequence on distortions. Three different welding directions, three different energy inputs as well as stitch welding have been evaluated, using resistance spot welding (RSW) as a reference. Transverse widening at the ends and narrowing at the centre of the beam were measured. A clear correlation was found between the weld metal volume and distortion. For continuous welds there was also a nearly linear relationship between the energy input and distortion. However, the amount of distortion was not affected by a change in welding direction. Stitching and RSW reduced distortion significantly compared to continuous laser welding.
|
|
| 17. |
- Fahlström, Karl, et al.
(författare)
-
Distortion Analysis in Laser Welding of Ultra High Strength Steel
- 2014
-
Ingår i: Proceedings of the 6th International Swedish Production Symposium 2014. - 9789198097412 ; , s. 1-9
-
Konferensbidrag (refereegranskat)abstract
- Due to increased demands on reduced weight in automotive industries, the use of ultra high strength steels (UHSS) has increased. When laser welding UHSS sheets, heating and cooling of the material will cause geometrical distortions and may cause low joint quality. 700 mm long U-beam structures of 1 mm thick boron steel simulating structural pillars in body-in-white constructions have been welded along the flanges with different welding speeds to investigate distortions and weld quality. The results show that final distortions appear in the range of 0-8 mm. FE simulation methods have also been presented which generally predict the distribution of welding distortions.
|
|
| 18. |
- Fahlström, Karl, 1986-, et al.
(författare)
-
Metallurgical effects and distortions in laser welding of thin sheet steels with variations in strength
- 2017
-
Ingår i: Science and technology of welding and joining. - : Informa UK Limited. - 1362-1718 .- 1743-2936. ; 22:7, s. 573-579
-
Tidskriftsartikel (refereegranskat)abstract
- Geometrical distortions occur while welding, but the understanding of how and why they occur and how to control them is limited. The relation between the weld width, weld metal volume, total energy input, width of hard zone and distortions when laser welding three different thin sheet steels with varying strength has therefore been studied. Weld metal volume and total energy input show a good correlation with distortion for one steel at a time. The best correlation with the when including all three steel grades was the width of the hard zone composed of weld metal and the martensitic area in the heat affected zone. © 2017 Institute of Materials, Minerals and Mining.
|
|
| 19. |
- Galvan-Valencia, Oscar, et al.
(författare)
-
Associations of salivary aldosterone levels during pregnancy with maternal blood pressure and birth weight-for-gestational age in a Mexico City birth cohort
- 2024
-
Ingår i: Journal of Perinatology. - : Springer Nature. - 0743-8346 .- 1476-5543. ; 44:5, s. 643-649
-
Tidskriftsartikel (refereegranskat)abstract
- ObjectiveTo determine associations of maternal salivary aldosterone with blood pressure (BP) in pregnancy and infant birth weight-for-gestational age (BWGA).MethodsWe measured maternal salivary aldosterone, BP and BWGA z-scores in 471 Mexico City pregnancy cohort participants and performed multivariable linear regression of BP and BWGA on log-aldosterone levels.ResultsLog-aldosterone was positively associated with diastolic BP (beta = 0.12 95% CI: 0.04, 0.21). There were no main effects of log-aldosterone on BWGA. However, we detected an interaction between log-aldosterone and BP in association with BWGA; higher log-aldosterone was associated with lower BWGA in the lowest (beta = -0.12, 95% CI: -0.26, 0.02) and highest (beta = -0.12, 95% CI: -0.29, 0.06) BP tertiles. In contrast, in the middle BP tertile the association was positive (beta = 0.09, 95% CI: -0.02, 0.20), p for interaction = 0.03.ConclusionHigher maternal salivary aldosterone is positively associated with diastolic BP and may affect fetal growth differently depending on concurrent maternal blood pressure.
|
|
| 20. |
- Gopakumar, Geethanjali, 1992-, et al.
(författare)
-
X-ray Induced Fragmentation of Protonated Cystine
-
Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Protein structure determination using high-intensity X-ray sources induces damage in the protein. Disulfide bridges, formed between two cysteine amino acid residues stabilize the protein structure. Owing to the higher absorption cross-section of sulfur for X-ray photons, and a large number of electrons released from sulfur atoms, these disulfide bridges are hot spots for a higher level of noise in structural studies. But it is yet to be understood how exactly the damage occurs through the interaction of the disulfide bridges with photons. Here we study the fragmentation of protonated cystine in the gas phase, which is the dimer of cysteine, by irradiation with X-rays across the sulfur L-edge using an electrospray ionization source (ESI) in combination with an ion trap. This is complemented with the calculation of the sulfur NEXAFS spectrum on the level of Restricted Open-Shell Configuration Interaction (ROCIS) and Density Functional Theory (DFT) calculations for molecular orbital visualization as well as Molecular Dynamics (MD) simulations for the fragmentation of triply charged cystine ions. We have deduced a possible pathway of fragmentation upon excitation and ionization of S 2p electrons by combining the experiments and simulations. The disulfide bridge breaks for resonant excitation at lower energies but remains intact upon higher energy resonant excitation and upon ionization of S 2p. The larger fragments formed subsequently break into smaller fragments.
|
|
| 21. |
- Gopakumar, Geethanjali, 1992-, et al.
(författare)
-
X-ray Induced Fragmentation of Protonated Cystine
- 2022
-
Ingår i: Journal of Physical Chemistry A. - : American Chemical Society (ACS). - 1089-5639 .- 1520-5215. ; 126:9, s. 1496-1503
-
Tidskriftsartikel (refereegranskat)abstract
- We demonstrate site-specific X-ray induced fragmentation across the sulfur L-edge of protonated cystine, the dimer of the amino acid cysteine. Ion yield NEXAFS were performed in the gas phase using electrospray ionization (ESI) in combination with an ion trap. The interpretation of the sulfur L-edge NEXAFS spectrum is supported by Restricted Open-Shell Configuration Interaction (ROCIS) calculations. The fragmentation pathway of triply charged cystine ions was modeled by Molecular Dynamics (MD) simulations. We have deduced a possible pathway of fragmentation upon excitation and ionization of S 2p electrons. The disulfide bridge breaks for resonant excitation at lower photon energies but remains intact upon higher energy resonant excitation and upon ionization of S 2p. The larger fragments initially formed subsequently break into smaller fragments.
|
|
| 22. |
- Gündüz, Kerem, 1985, et al.
(författare)
-
The effect of hydrogen on the breakdown of the protective oxide scale in solid oxide fuel cell interconnects
- 2021
-
Ingår i: Corrosion Science. - : Elsevier BV. - 0010-938X. ; 179
-
Tidskriftsartikel (refereegranskat)abstract
- In this study, the effect of hydrogen, on the degradation of AISI 441 interconnect, under solid oxide fuel cell operating conditions was investigated between 500−800 °C for 336 h. As a new hypothesis, it is concluded that, hydrogen impedes Cr diffusion, probably in the grain boundaries, leading to the breakdown of the protective oxide scale. This effect is most severe at 600 °C, while at lower or higher temperatures the effect is attenuated. Cr diffusion is enhanced at high temperatures, whereas protective scales can be obtained at low temperatures with a lower amount of Cr.
|
|
| 23. |
- Jalnefjord, Oscar, 1989, et al.
(författare)
-
Comparison of methods for estimation of the intravoxel incoherent motion (IVIM) diffusion coefficient (D) and perfusion fraction (f)
- 2018
-
Ingår i: Magnetic Resonance Materials in Physics, Biology and Medicine. - : Springer Science and Business Media LLC. - 0968-5243 .- 1352-8661. ; 31:6, s. 715-723
-
Tidskriftsartikel (refereegranskat)abstract
- Objective: Intravoxel incoherent motion (IVIM) shows great potential in many applications, e.g., tumor tissue characterization. To reduce image-quality demands, various IVIM analysis approaches restricted to the diffusion coefficient (D) and the perfusion fraction (f) are increasingly being employed. In this work, the impact of estimation approach for D and f is studied. Materials and methods: Four approaches for estimating D and f were studied: segmented IVIM fitting, least-squares fitting of a simplified IVIM model (sIVIM), and Bayesian fitting of the sIVIM model using marginal posterior modes or posterior means. The estimation approaches were evaluated in terms of bias and variability as well as ability for differentiation between tumor and healthy liver tissue using simulated and in vivo data. Results: All estimation approaches had similar variability and ability for differentiation and negligible bias, except for the Bayesian posterior mean of f, which was substantially biased. Combined use of D and f improved tumor-to-liver tissue differentiation compared with using D or f separately. Discussion: The similar performance between estimation approaches renders the segmented one preferable due to lower numerical complexity and shorter computational time. Superior tissue differentiation when combining D and f suggests complementary biologically relevant information.
|
|
| 24. |
|
|
| 25. |
|
|
| 26. |
- Lundin, Oscar, et al.
(författare)
-
Prediction of eigenfrequencies in non-rectangular rooms with machine learning
- 2022
-
Ingår i: Proceedings of the 24th International Congress on Acoustics. ; , s. 1-5
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Knowing the eigenfrequencies of a space is important for designing its acoustic performance at low frequencies. The eigenfrequencies can be analytically calculated for a limited set of room shapes, while for more complex domains it is common to use Finite Element methods (FEM). This paper investigates the use of Convolutional Neural Networks (CNN) to predict the eigenfrequencies based on a digital image of a 2D room shape. FEM software is used to create a training set of pseudorandom room shapes and identify their eigenfrequencies. In this study, only rooms with rigid walls are studied, and the CNN is used to predict the first ten eigenfrequencies for rooms with normalized surface area. The rooms have three to sixteen walls, including slanted walls and non-convex geometries, as well as corridor rooms. The accuracy of this approach is compared to the FEM solutions, as well as to analytical solutions for room shapes with solutions available.
|
|
| 27. |
|
|
| 28. |
- Morales Chacon, Oscar Andres, 1985-, et al.
(författare)
-
Analysis of energy consumption bounds in CMOS current-steering digital-to-analog cosnverters
- 2022
-
Ingår i: Analog Integrated Circuits and Signal Processing. - : Springer. - 0925-1030 .- 1573-1979. ; 111, s. 339-351
-
Tidskriftsartikel (refereegranskat)abstract
- In this paper, an attempt to estimate energy consumption bounds versus signal-to-noise ratio (SNR) and spurious-free dynamic range (SFDR) in CMOS current-steering digital-to-analog converters is presented. A theoretical analysis is derived, including the design corners for noise, speed and linearity for the mixed-signal domain. The study is validated by comparing the theoretical results with published measured data. As result it serves as a design reference to aim for minimum energy consumption. It is found that for an equivalent number of bits (ENOBs), the noise-bound grows at a rate of 2(2ENOB), whereas the speed-bound increases by 2(ENOB-2) and is dependent on device dimensions. Therefore, as the technology scales down, the noise bound will dominate, which is observed for an estimated SNR of about 40 dB in 65 nm CMOS process. The linearity bound is derived from an analysis based on the assumption of limited output impedance, where it is found to be dependent on the device dimensions and increase at a rate of 2(ENOB-1). The observations show that it is possible to achieve less energy consumption in all the design corners for different SNR and SFDR specifications within the Nyquist frequency, f(s)/2.
|
|
| 29. |
- Smith, Gustav, et al.
(författare)
-
Triple antithrombotic therapy following an acute coronary syndrome: prevalence, outcomes and prognostic utility of the HAS-BLED score.
- 2012
-
Ingår i: EuroIntervention. - 1969-6213. ; 8:6, s. 672-678
-
Tidskriftsartikel (refereegranskat)abstract
- Aims: The aim of this study was to evaluate the prevalence of triple antithrombotic therapy (TT) (warfarin, aspirin and clopidogrel) in patients following an acute coronary syndrome (ACS), the bleeding risk compared to double antiplatelet therapy (DAPT) (aspirin and clopidogrel) and evaluate the accuracy of the HAS-BLED risk score in predicting serious bleeding events in TT patients. Methods and results: We retrospectively identified all ACS patients on TT upon discharge from the Coronary Care Unit at Skane University Hospital between 2005 and 2010. TT patients were compared to age- and sex-matched control patients discharged with DAPT. Major bleeding was defined in accordance with the HAS-BLED derivation study. A total of 2,423 patients were screened, of whom 159 (6.6%) were on TT. The mean age was 67.2 (±0.9) years. The most common indication for TT was atrial fibrillation (n=63, 39.6%) followed by apical akinesia (n=60, 37.8%), and the mean duration of TT was 3.7 (±0.3) months. Upon termination of TT, warfarin was discontinued in 82 (52.2%) patients and clopidogrel in 57 (36.3%) patients. The cumulative incidence of spontaneous bleeding events was significantly higher with TT compared to DAPT at one year (10.2% vs. 3.2%; p=0.01). The HAS-BLED score significantly predicted spontaneous bleeding events in TT patients (area under the receiver operating characteristic [ROC] curve 0.67; 95% CI=0.54-0.79; p=0.048). Conclusions: TT was relatively common following acute coronary syndrome and was associated with a threefold increase in major bleeding compared to DAPT at one year. The HAS-BLED risk score predicted bleeding events with moderate accuracy.
|
|
| 30. |
- Svensson, Måns, et al.
(författare)
-
New Environmental Zones for Passenger Cars : Attitudes, Norms and Legal Compliance
- 2019
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The fundamental premise for the present report is to examine the degree to which it is possible to predict compliance with future rules regarding environmental zones for passenger cars. This project combines the main quantitative survey study (Sub-study 1) with a semi-systematic literature review that is first and foremost based in a qualitative, thematic analysis (Sub-study 2).The survey study is based in Icek Ajzen’s Theory of Planned Behaviour (TPB) and consists of a socio-psychological model that can be used to predict behaviour and develop strategies for changing people’s behaviours. This theory focuses on behaviours that are preceded by cognitive processes which, in turn, lead to intentions that result in the individual taking action.
|
|
| 31. |
- Svensson, Måns, et al.
(författare)
-
Näthat och demokratiskt deltagande – en kunskapsöversikt
- 2021
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Rätten att uttrycka åsikter, att kritisera och att ifrågasätta är en del av enlevande demokrati. Ett demokratiskt samhälle måste vara öppet för olikaröster och ge alla möjlighet att komma till tals. Demokratin är beroendeav att människor deltar och engagerar sig i samhällsfrågor. Med rättentill yttrandefrihet kommer också ett ansvar. Var och en bör skydda, värnaoch bevara yttrandefriheten genom att respektera andra och bidra till ensamhällsdebatt fri från hot och hat. Tystas människor tystnar demokratin.Den digitala utvecklingen gör det möjligt för fler att göra sin röst hörd. Det ärpositivt men för också med sig utmaningar. Att föra fram och sprida hot ochhat har blivit enklare. Uttalanden kan få snabb spridning i sociala medier ochpå så sätt få större genomslagskraft i dag än tidigare. Det kan missbrukas avpersoner som inte vill bevara det demokratiska samhället.Personer som engagerar sig i samhällsfrågor är särskilt utsatta för hotoch hat. Det gäller till exempel förtroendevalda, journalister, konstnärer,opinionsbildare, forskare och representanter för det civila samhället. Utsatthetkan också vara kopplat till exempelvis en persons kön, könsidentitet, hudfärg,sexuella läggning eller ålder. När kvinnor och hbtqi-personer får hot och hatriktat mot sig har det ofta att göra med kön och sexualitet.På uppdrag av Brottsoffermyndigheten har forskare vid Lunds universitetoch Högskolan i Halmstad genomfört en enkätundersökning som visadeatt mer än hälften av de tillfrågade har känt sig kränkta av sådant som andraskriver om dem på nätet. Särskilt utsatta är unga och personer med utländskbakgrund, och följden blir omfattande nivåer av självcensur bland dessagrupper. Det innebär att de anpassar hur de uttrycker sig för att undvika hotoch hat, eller helt avstår från att publicera och delta i samhällsdebatten. Detdemokratiska samtalet begränsas och viktiga röster riskerar att tystna.Även denna kunskapsöversikt är ett resultat av samarbetet mellan Brottsoffer- myndigheten, Lunds universitet och Högskolan i Halmstad. Den belyser olika frågor om näthat och demokratiskt deltagande, såsom vilka områden som genererar hot och hat, vilka samhälls- och yrkesgrupper som är särskilt utsatta och vilka konsekvenser näthat leder till.
|
|
| 32. |
- Svensson, Martina, et al.
(författare)
-
Voluntary running does not reduce neuroinflammation or improve non-cognitive behavior in the 5xFAD mouse model of Alzheimer’s disease
- 2020
-
Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 10
-
Tidskriftsartikel (refereegranskat)abstract
- Physical exercise has been suggested to reduce the risk of developing Alzheimer’s disease (AD) as well as ameliorate the progression of the disease. However, we recently published results from two large epidemiological studies showing no such beneficial effects on the development of AD. In addition, long-term, voluntary running in the 5xFAD mouse model of AD did not affect levels of soluble amyloid beta (Aβ), synaptic proteins or cognitive function. In this follow-up study, we investigate whether running could impact other pathological aspects of the disease, such as insoluble Aβ levels, the neuroinflammatory response and non-cognitive behavioral impairments. We investigated the effects of 24 weeks of voluntary wheel running in female 5xFAD mice (n = 30) starting at 2–3 months of age, before substantial extracellular plaque formation. Running mice developed hindlimb clasping earlier (p = 0.009) compared to sedentary controls. Further, running exacerbated the exploratory behavior in Elevated plus maze (p = 0.001) and anxiety in Open field (p = 0.024) tests. Additionally, microglia, cytokines and insoluble Aβ levels were not affected. Taken together, our findings suggest that voluntary wheel running is not a beneficial intervention to halt disease progression in 5xFAD mice.
|
|
| 33. |
- Svensson, Oscar, et al.
(författare)
-
Structure reconsidered: Towards new foundations of explanatory transitions theory
- 2018
-
Ingår i: Research Policy. - 0048-7333. ; 47:2, s. 462-473
-
Tidskriftsartikel (refereegranskat)abstract
- The most prominent framework for studying socio-technical transitions to date is the multi-level perspective (MLP). While appreciated for its flexibility and usefulness for studying socio-technical transitions it has not been without its critics. In this paper we focus on the ontological foundations of the MLP and its (in)ability to explain transitions and how they come about. The purpose is to initiate development of an explanatory theory for socio-technical transitions, by carrying out an immanent critique of the ontological foundations of the MLP together with a methodological critique. We show that the ontological foundations of the MLP to a large extent inhibits explanatory capacity. The argument is fourfold: since structure and agency are understood as inseparable, (i) the causal influence of material properties are undervalued, and (ii) different degrees of structural constraint and freedom of actors are ignored. As a consequence (iii) transitions are reduced to shifts in the maturity and spread of socio-cognitive rules, without analysis of systemic change. Moreover, (iv) mechanisms are reduced to recurring patterns of events which cannot explain why some transitions fail while others succeed. To remedy these limitations we outline alternative critical realist foundations for transitions theory.
|
|
| 34. |
- Svensson, Oscar, et al.
(författare)
-
Studying industrial decarbonisation : Developing an interdisciplinary understanding of the conditions for transformation in energy-intensive natural resource-based industry
- 2020
-
Ingår i: Sustainability (Switzerland). - : MDPI AG. - 2071-1050. ; 12:5
-
Tidskriftsartikel (refereegranskat)abstract
- The ambition to keep global warming well below 2°C above pre-industrial levels, as recognised in the Paris Agreement, implies a reorientation towards low-carbon societal development and, ultimately, the decarbonisation of human societies and economies. While climate policy has been geared towards achieving set emission reduction targets, the decarbonisation of key socioeconomic sectors such as energy-intensive natural resource-based industries (ENRIs) has not yet been sufficiently addressed, neither politically nor in science. Decarbonising the ENRIs is a complex societal problem that will require structural transformation technologically as well as socially. Understanding the conditions for transformative change therefore necessitates integrated knowledge from multiple perspectives of different research fields. In this paper, we examine the potential of combining three different research fields and critically scrutinize the challenges to integration for understanding the conditions for industrial decarbonisation: energy system analysis, sustainability transition research and policy studies. We argue that these perspectives are complementary-a fundamental condition for fruitful integration-but not easily compatible since they are sometimes based on different ontological assumptions. The research fields are in themselves heterogeneous, which poses additional challenges to an integrated research approach. Drawing on experiences from a Swedish research project (GIST2050) on industrial decarbonisation, we suggest a modest approach to integrated research that could progressively develop from multidisciplinary exchange towards more integrated forms of interdisciplinarity by means of cross-disciplinary dialogue and understanding.
|
|
| 35. |
- Svensson, Oscar
(författare)
-
The matter of energy emerges: Bridging the divide between conflicting conceptions of energy resources
- 2021
-
Ingår i: Energy Research & Social Science. - : Elsevier BV. - 2214-6296. ; 72
-
Tidskriftsartikel (refereegranskat)abstract
- After decades of theoretical neglect of material properties and relations, a much welcome material turn within social science energy research has recently raised discussions of materiality to the centre of current debates. So far, the efforts to rematerialize energy has to a large extent drawn on new materialist thinking. Against the substantivalist conception of energy resources as self-standing natural things with inherent properties new materialists have developed relational conceptions that are anti-essentialist and emphasize indeterminacy, contingency, and unruliness. This article critically and constructively discusses new materialism, some of its limitations and problems, and how a critical realist perspective can resolve these. Based on the concept of emergence, a stratified conception of natural resources is developed, which seeks to dialectically sublate conceptions of natural resources as either things-in-themselves with intrinsic properties or relational effects.
|
|
| 36. |
- Svensson, Pamela, et al.
(författare)
-
Heavy element incorporation in nitroimidazole radiosensitizers : molecular-level insights into fragmentation dynamics
- 2024
-
Ingår i: Physical Chemistry, Chemical Physics - PCCP. - : Royal Society of Chemistry. - 1463-9076 .- 1463-9084. ; 26:2, s. 770-779
-
Tidskriftsartikel (refereegranskat)abstract
- The present study investigates the photofragmentation behavior of iodine-enhanced nitroimidazole-based radiosensitizer model compounds in their protonated form using near-edge X-ray absorption mass spectrometry and quantum mechanical calculations. These molecules possess dual functionality: improved photoabsorption capabilities and the ability to generate species that are relevant to cancer sensitization upon photofragmentation. Four samples were investigated by scanning the generated fragments in the energy regions around C 1s, N 1s, O 1s, and I 3d-edges with a particular focus on NO2+ production. The experimental summed ion yield spectra are explained using the theoretical near-edge X-ray absorption fine structure spectrum based on density functional theory. Born-Oppenheimer-based molecular dynamics simulations were performed to investigate the fragmentation processes.
|
|
| 37. |
|
|
| 38. |
- Törnqvist, Oscar, 1969-
(författare)
-
Röster från ingenmansland : En identitetsarkeologi i ett maritimt mellanrum
- 2019
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Archaeological investigations into late iron age and medieval coastal societies in Sweden have been focusing on a maritime culture, a traditional coastal and island-dwelling fisher-farmer and activities centered on fishing in a long maritime tradition as well as a specific maritime identity and habitus. By deconstructing commonly used concepts and by using primarily written sources, it is here shown that there is a need for putting this culture and its agents into perspective by opening up the history of the maritime interspace and let in previously overlooked or disregarded historical actors in the narrative field dominated by men and landed farmers, such as landless, powerless, strangers, foreigners and women.The coast is shown to have been an arena for opportunism, societal expansion under landed gentry, nodes for procurement and social oppression and focal points for inter-cultural contacts, trade, networking and self-realization and that the role of the islands and the “fisheries” was constantly remolded to fit different power strategies.Through a series of case studies, seldom discussed social relations, social groups and social predicaments are unmasked and discussed; the relation between norse and proto-Saami cultures, the role of women in fishing, employment of the poor or serfs, of incentives by strangers and foreigners. Many localities speak of conflict, struggle and self-sought or forced marginalization; the emergence of taxation and the control of fishing, piracy and insurgency but also of exile, reclusion and asceticism. Running through history there has been a dichotomy and tension between the workforce and the benefactor, between small-scale and large-scale maritime procurement, between cooperation and conflict and between the meeting place and the hidden refuge.To conclude, the study sketches the ethno genesis of the hitherto “fisher-farmer” and exposes a wider set of actors and their strategies in the maritime space and ends with advocating a series of potentially fruitful research frameworks of study; cultural niches in the maritime environment, actor geographies in the outback, the use of maritime produce in societal transformations, and to further investigate the harsh, hidden or exposed, islands as places for sociocultural and economical strategies with profound social, psychological and spiritual impact.
|
|
| 39. |
- van der Laan, Sander W., et al.
(författare)
-
Cystatin C and Cardiovascular Disease : A Mendelian Randomization Study
- 2016
-
Ingår i: Journal of the American College of Cardiology. - : Elsevier BV. - 0735-1097 .- 1558-3597. ; 68:9, s. 934-945
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND Epidemiological studies show that high circulating cystatin C is associated with risk of cardiovascular disease (CVD), independent of creatinine-based renal function measurements. It is unclear whether this relationship is causal, arises from residual confounding, and/or is a consequence of reverse causation. OBJECTIVES The aim of this study was to use Mendelian randomization to investigate whether cystatin C is causally related to CVD in the general population. METHODS We incorporated participant data from 16 prospective cohorts (n = 76,481) with 37,126 measures of cystatin C and added genetic data from 43 studies (n = 252,216) with 63,292 CVD events. We used the common variant rs911119 in CST3 as an instrumental variable to investigate the causal role of cystatin C in CVD, including coronary heart disease, ischemic stroke, and heart failure. RESULTS Cystatin C concentrations were associated with CVD risk after adjusting for age, sex, and traditional risk factors (relative risk: 1.82 per doubling of cystatin C; 95% confidence interval [CI]: 1.56 to 2.13; p = 2.12 x 10(-14)). The minor allele of rs911119 was associated with decreased serum cystatin C (6.13% per allele; 95% CI: 5.75 to 6.50; p = 5.95 x 10(-211)), explaining 2.8% of the observed variation in cystatin C. Mendelian randomization analysis did not provide evidence fora causal role of cystatin C, with a causal relative risk for CVD of 1.00 per doubling cystatin C (95% CI: 0.82 to 1.22; p = 0,994), which was statistically different from the observational estimate (p = 1.6 x 10(-5)). A causal effect of cystatin C was not detected for any individual component of CVD. CONCLUSIONS Mendelian randomization analyses did not support a causal role of cystatin C in the etiology of CVD. As such, therapeutics targeted at lowering circulating cystatin C are unlikely to be effective in preventing CVD.
|
|
| 40. |
- Vogl, Valentin, et al.
(författare)
-
A just transition towards a coal-free steel industry: perspectives from labour
- 2019
-
Ingår i: 14th Nordic Environmental Social Science (NESS). ; , s. 1-30
-
Konferensbidrag (refereegranskat)abstract
- Limiting global warming to ‘safe’ levels will require rapid and radical reductions of greenhouse gas emissions across all sectors of the global economy. The discontinuation of incumbent industrial structures, that will be an unavoidable part of such sustainability transitions, will disproportionally burden certain groups. Recent events including the social and political unrest linked to the imminent deterioration of coal communities and the fuel tax protests of the ’Gilets Jaunes’ have loudly shown that distributional effects of climate transitions cannot be ignored. Trade unions and NGOs have for some time called for an inclusive transition and brought increased attention to the justice dimension of energy transitions. In this paper, we analyse potential social impacts in a concrete case: the planned transition from coal to hydrogen-based steelmaking in the Swedish steel industry. To this end, we conduct a series of semi-structured interviews to examine the role of trade unions and the national trade union federation in re-orienting the industry. By doing so we aim to widen the scope of the just transitions debate to include process industries and to explore the concrete meaning of a just transition in the case of the planned transition of the Swedish steel industry. We analyse, on the one hand, the capacity of trade unions to influence the transition process, and, on the other hand, the potential social impacts of the transition on the labour force and local communities. As the transition of the Swedish steel sector kicks into gear, we highlight a number of social issues that should be addressed both within industry and through policy. We conclude that it is important to early on: include stakeholders in the process, bring up social and political aspects of the transition, and acknowledge and address potential conflicting interests associated with it.
|
|
| 41. |
- von Schenck, H., et al.
(författare)
-
CO bonding on tin modified Pt(110)-(1 x 2)
- 2003
-
Ingår i: Surface Science. - : Elsevier BV. - 0039-6028 .- 1879-2758. ; 526:02-jan, s. 184-192
-
Tidskriftsartikel (refereegranskat)abstract
- The influence of tin on the bonding of CO to Pt(l 10) has been studied using high-resolution electron energy loss spectroscopy, density functional theory and photoelectron spectroscopy. CO binds on-top to platinum at all investigated tin and CO coverages. Bonding of CO in Sn-Pt alloy rows is weakened compared to clean Pt(l 10). However, several different adsorption sites in Pt-only rows, inequivalent with regard to their coordination environment, show very similar characteristics with respect to CO adsorption.
|
|
| 42. |
- Wuttke, Matthias, et al.
(författare)
-
A catalog of genetic loci associated with kidney function from analyses of a million individuals
- 2019
-
Ingår i: Nature Genetics. - : NATURE PUBLISHING GROUP. - 1061-4036 .- 1546-1718. ; 51:6, s. 957-972
-
Tidskriftsartikel (refereegranskat)abstract
- Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.
|
|
