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- Christensen, Love, et al.
(författare)
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Fotbollssupportrar i Göteborg redux
- 2012
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Ingår i: Medborgarna om välfärden. - Göteborg : University of Gothenburg. - 9789189673250
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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- Gising, Johan, 1981-, et al.
(författare)
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Achiral Pyrazinone-Based Inhibitors of the Hepatitis C Virus NS3 Protease and Drug-Resistant Variants with Elongated Substituents Directed Toward the S2 Pocket
- 2014
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Ingår i: Journal of Medicinal Chemistry. - : American Chemical Society (ACS). - 0022-2623 .- 1520-4804. ; 57:5, s. 1790-1801
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Tidskriftsartikel (refereegranskat)abstract
- Herein we describe the design, synthesis, inhibitory potency, and pharmacokinetic properties of a novel class of achiral peptidomimetic HCV NS3 protease inhibitors. The compounds are based on a dipeptidomimetic pyrazinone glycine P3P2 building block in combination with an aromatic acyl sulfonamide in the P1P1′ position. Structure–activity relationship data and molecular modeling support occupancy of the S2 pocket from elongated R6 substituents on the 2(1H)-pyrazinone core and several inhibitors with improved inhibitory potency down to Ki = 0.11 μM were identified. A major goal with the design was to produce inhibitors structurally dissimilar to the di- and tripeptide-based HCV protease inhibitors in advanced stages of development for which cross-resistance might be an issue. Therefore, the retained and improved inhibitory potency against the drug-resistant variants A156T, D168V, and R155K further strengthen the potential of this class of inhibitors. A number of the inhibitors were tested in in vitro preclinical profiling assays to evaluate their apparent pharmacokinetic properties. The various R6 substituents were found to have a major influence on solubility, metabolic stability, and cell permeability.
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- Joffrin, E., et al.
(författare)
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Overview of the JET preparation for deuterium-tritium operation with the ITER like-wall
- 2019
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 59:11
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Forskningsöversikt (refereegranskat)abstract
- For the past several years, the JET scientific programme (Pamela et al 2007 Fusion Eng. Des. 82 590) has been engaged in a multi-campaign effort, including experiments in D, H and T, leading up to 2020 and the first experiments with 50%/50% D-T mixtures since 1997 and the first ever D-T plasmas with the ITER mix of plasma-facing component materials. For this purpose, a concerted physics and technology programme was launched with a view to prepare the D-T campaign (DTE2). This paper addresses the key elements developed by the JET programme directly contributing to the D-T preparation. This intense preparation includes the review of the physics basis for the D-T operational scenarios, including the fusion power predictions through first principle and integrated modelling, and the impact of isotopes in the operation and physics of D-T plasmas (thermal and particle transport, high confinement mode (H-mode) access, Be and W erosion, fuel recovery, etc). This effort also requires improving several aspects of plasma operation for DTE2, such as real time control schemes, heat load control, disruption avoidance and a mitigation system (including the installation of a new shattered pellet injector), novel ion cyclotron resonance heating schemes (such as the three-ions scheme), new diagnostics (neutron camera and spectrometer, active Alfven eigenmode antennas, neutral gauges, radiation hard imaging systems...) and the calibration of the JET neutron diagnostics at 14 MeV for accurate fusion power measurement. The active preparation of JET for the 2020 D-T campaign provides an incomparable source of information and a basis for the future D-T operation of ITER, and it is also foreseen that a large number of key physics issues will be addressed in support of burning plasmas.
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- Lindberg, Staffan I, 1969, et al.
(författare)
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Rösträtt till salu: Det nya hotet mot demokratin
- 2012
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- World Values Survey-undersökningen i Sverige 2011 verkar säga något nytt och skrämmande om de unga mellan 18-29 år: - Var femte ung svensk mellan 18 och 29 år kan tänka sig att sälja sin röst för en mindre summa pengar. - Var fjärde ung svensk tycker inte att det är så viktigt att de får leva i en demokrati men tycker att det vore bra, eller mycket bra, om Sverige styrdes av en "stark ledare som inte behöver bry sig om riksdagen eller allmänna val". - Nästan 15 procent av de unga tycker att det vore bra, eller mycket bra, om Sverige styrdes av militären. Hur ska detta förstås och vilka är orsakerna? Statsvetarna Staffan I Lindberg och Richard Svensson söker svaren i de senaste årens politiska utveckling. Slutsatsen handlar om utbildningspolitikens förändringar. Dagens system har under de senaste 20 åren formats efter marknadens och det individuella valets princip stället för demokratins. Om denna utveckling får fortsätta riskerar den svenska demokratin att gå en mörk framtid till mötes.
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- Lindberg, Staffan I, 1969, et al.
(författare)
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Trust in Parliament
- 2017
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Ingår i: Journal of Public Affairs. - : Wiley. - 1472-3891. ; 17:2
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Tidskriftsartikel (refereegranskat)abstract
- Parliaments are—or should at least be—the central rule‐making institutions in democratic countries. If people do not have faith in the institution making the rules, it is less likely that people live by them. Consequently, it is beneficiary if trust in parliament is high. But it is also a normative good in itself. If the people do not trust the key institution whereby they can exercise “rule by the people over itself,” democracy itself is endangered. Secondly, trust levels should be reasonably even spread among relevant social and political groups in a society because parliament should ideally be a nonpartisan level playing field. However, because the majority in parliament typically chooses and sustains the acting government, one could say that legislatures in parliamentary democracies should not be level playing fields. According to this argument, there should be differences in trust in parliament between groups of individuals with varying political affiliations. Supporters of the majority in parliament should be expected to have higher trust in the legislature compared to citizens who voted for the opposition. We test our three hypotheses on data from some 80 countries participating in World Value Survey, either in Waves 5 or 6. We find that people in both new and established democracies harbor lower levels of trust than an intuitive interpretation of normative theory would lead us to expect. We also find that the attitudes of tens of thousands of citizens garnered from across 42 new and old democracies suggest that levels of average trust in groups of these societies are not as equally distributed, as a simple reading of democratic theory would have us to believe. In particular, individuals with a stronger interest in politics, and who are winners by the account of the last election, have statistically substantively relevant higher average levels of trust in parliament as an institution than do other citizens. The latter seems to us especially potentially problematic in particular for some of the new democracies where majority‐dominant parties manage to cling on to power over several election cycles. If what we find here were generally applicable also over several election cycles, we would expect the gap between winners and losers to widen and sediment and potentially sow the seeds of anti‐system movements opposed to democracy. Parliament is obviously a partisan creature in the eyes of most citizens in democracies. The level playing field idea does not fly.
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- Olofsdotter Stensöta, Helena, 1965, et al.
(författare)
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Gender and Corruption. The mediating Power of Institutional Logics
- 2015
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Ingår i: Governance. An International Journal of Policy, Administration and Institutions. - : Wiley. - 0952-1895 .- 1468-0491. ; 28:4, s. 475-496
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Tidskriftsartikel (refereegranskat)abstract
- Scholars have argued that recruiting more women to office is an effective way to curb corruption; however, the more precise mechanisms underlying why this may be the case have remained unclear. We use meso-level theories to elaborate on the relationship and suggest that institutional logics mediate the effect of gendered experiences on corruption. We make two propositions: First, we suggest that the relationship between more women and lower levels of corruption is weaker in the state administration than in the legislative arena, because the bureaucratic administrative logic absorbs actors’ personal characteristics. Second, we refine our institutional argument by claiming that the stronger the bureaucratic principles are in the administration, the less gender matters. We validate our theory using data provided by the European Commission (EC) covering the EC countries and original data from the Quality of Government Institute Expert Surveys, covering a larger set of countries on a worldwide scale.
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